phenylalanine has been researched along with batimastat in 308 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 99 (32.14) | 18.2507 |
| 2000's | 159 (51.62) | 29.6817 |
| 2010's | 47 (15.26) | 24.3611 |
| 2020's | 3 (0.97) | 2.80 |
| Authors | Studies |
|---|---|
| Belotti, D; Borsotti, P; Brown, PD; Drudis, T; Garofalo, A; Giavazzi, R; Scanziani, E; Taraboletti, G | 1 |
| Copeland, J; Gilbertson-Beadling, S; Ledbetter, S; Mitchell, M; Petzold, G; Poorman, R; Powers, EA; Scott, PS; Stamp-Cole, M; Wallace, TL | 1 |
| Bone, EA; Fife, R; Goulet, R; Qulali, M; Sledge, GW | 1 |
| Brown, PD | 2 |
| Cawston, TE; Curry, V; Ellis, AJ; Humm, G; Lean, E; Ward, D | 1 |
| Bode, W; Crimmin, M; Grams, F; Hinnes, L; Huxley, P; Pieper, M; Tschesche, H | 1 |
| Brown, PD; Crimmin, MJ; Hardcastle, JD; Morris, TM; Robinson, G; Watson, SA | 1 |
| Crimmin, MJ; DiMartino, MJ; Galloway, WA; High, W | 1 |
| Bawden, LJ; Brown, PD; Chirivi, RG; Crimmin, MJ; Garofalo, A; Giavazzi, R; Stoppacciaro, A | 1 |
| Brown, PD; Crimmin, MJ; Fu, X; Hoffman, RM; Wang, X | 1 |
| Barrett, AJ; Buttle, DJ; Handley, CJ; Ilic, MZ; Murata, M; Saklatvala, J | 1 |
| Balkwill, FR; Brown, PD; Crimmin, MJ; Davies, B; East, N | 1 |
| Coffey, JW; Hanglow, AC; Lusch, L; Rowan, K | 1 |
| Clowes, AW; Kenagy, RD; Koyama, N; Lea, HJ; Zempo, N | 1 |
| Botos, I; Liotta, LA; Meyer, EF; Scapozza, L; Zhang, D | 1 |
| Akizawa, T; Itoh, M; Kinoshita, T; Sato, H; Seiki, M; Takino, T | 1 |
| Bone, EA; Box, GM; Brown, PD; Court, WJ; Eccles, SA; Thomas, W | 1 |
| Dencoff, JE; Estrada, EY; Rosenberg, GA; Stetler-Stevenson, WG | 1 |
| Brown, PD; Giavazzi, R | 1 |
| Kinoshita, T; Nakayama, K; Sato, H; Seiki, M; Takino, T | 1 |
| Brown, PD; Morris, TM; Parsons, SL; Steele, RJ; Watson, SA | 1 |
| Ali, SA; Goepel, JR; Goyns, MH; Rees, RC; Zubair, AC | 1 |
| Barter, J; Cole, A; Dickson, R; Hawkins, MJ; Low, J; Marshall, J; McCann, P; Moore, J; Ness, E; Sale, M; Wojtowicz-Praga, S | 1 |
| Kuwano, M; Ono, M | 2 |
| Brown, PD; Talbot, DC | 1 |
| Apinhasmit, W; Baum, BJ; Birkedal-Hansen, H; Chen, ZJ; Lafrenie, RM; Park, C; Stetler-Stevenson, WG; Wu, AJ; Yamada, KM | 1 |
| Dickson, RB; Hawkins, MJ; Wojtowicz-Praga, SM | 1 |
| Falk-Marzillier, J; Giannelli, G; Quaranta, V; Schiraldi, O; Stetler-Stevenson, WG | 1 |
| Franz, MG; Gower, WR; Norman, JG; Rosemurgy, AS; Zervos, EE | 1 |
| Betz, M; Bode, W; Davies, SJ; Gomis-Rüth, FX; Huxley, P; Mushtaq, Y; Pieper, M; Tschesche, H | 1 |
| Coffey, RJ; Dempsey, PJ; Meise, KS; Nishikawa, K; Yoshitake, Y | 1 |
| Buckle, DR; Hooper, NM; Karran, EH; Oppong, SY; Parvathy, S; Turner, AJ | 1 |
| McCann, PP; Rasmussen, HS | 1 |
| Balkwill, FR; Burke, F; East, N; Patel, K; Upton, C | 1 |
| Denis, LJ; Verweij, J | 1 |
| Bianchi, G; Boraschi, D; Drummond, AH; Mantovani, A; Orlando, S; Sironi, M; Yabes, D | 1 |
| Delaissé, JM; Foged, NT; Sato, T | 1 |
| Barton, A; Bolognese, B; Buckle, DR; Christie, G; Cook, RM; Hansbury, MJ; Harper, GP; Marshall, LA; Mayer, RJ; McCord, ME; Moulder, K; Murdock, PR; Seal, SM; Spackman, VM; Weston, BJ | 1 |
| Hooper, NM; Hussain, I; Karran, EH; Parvathy, S; Turner, AJ | 2 |
| Parsons, SL; Steele, RJ; Watson, SA | 1 |
| Ingersoll, EP; Wilt, FH | 1 |
| Baramova, E; Brown, P; Calberg-Bacq, CM; Foidart, JM; Hajitou, A; Kebers, F; L'Hoir, C; Lewalle, JM; Maquoi, E; Noël, A; Remacle, A | 1 |
| Hori, N; Ikeda, S; Inoue, S; Ohishi, Y; Okada, Y; Tsujishita, H; Yamamoto, M | 1 |
| Adamson, RE; Brown, CG; Hall, FR; Somerville, RP | 1 |
| Bone, EA; Brown, PD; Chiari, S; Ferri, C; Garofalo, A; Giavazzi, R; Lucchini, V; Nicoletti, MI; Taraboletti, G | 1 |
| Bowden, GT; Bretton, L; Knox, JD; Lynch, T; Nagle, RB | 1 |
| McCullagh, K | 1 |
| Antcliff, J; Croucher, PI; Hargreaves, PG; Lawry, J; Murphy, G; Russell, RG; Wang, F | 1 |
| Burlingham, WJ; Bushkin, Y; Demaria, S; DeVito-Haynes, LD | 1 |
| Brown, CL; Carpenter, G; Dempsey, PJ; Rudolph-Owen, LA; Vecchi, M | 1 |
| Atassi, G; Boutin, JA; Desmet, C; Fauchère, JL; Ferry, G; Genton, A; Hennig, P; Tucker, GC | 1 |
| Eng, K; Galloway, AC; Marcus, SG; Mignatti, P; Monea, S; Patel, S; Schwartz, JD; Shamamian, P | 1 |
| Galloway, AC; Marcus, SG; Mignatti, P; Monea, S; Schwartz, JD; Shamamian, P; Whiting, D | 1 |
| Beattie, GJ; Smyth, JF | 1 |
| Frosch, M; Koedel, U; Lorenzl, S; Paul, R; Pfister, HW; Sporer, B; Vogel, U | 1 |
| Kadono, Y; Namiki, M; Sato, H; Seiki, M; Shibahara, K; Watanabe, Y | 1 |
| Brown, PD; Goss, KJ; Matrisian, LM | 1 |
| Bone, EA; Dickson, RB; Johnson, MD; Low, JA | 1 |
| Fukushima, P; Guedez, L; Mansoor, A; Stetler-Stevenson, M; Stetler-Stevenson, WG; Wang, J; Wolff, L | 1 |
| Epps, DE; Laborde, AL; Petzold, GL; Poorman, RA; Stuchly, CW; Van Drie, JH | 1 |
| Baker, AH; Furth, EE; Kalluri, R; Lei, H; Strauss, JF | 1 |
| Furth, EE; Jeffrey, JJ; Kallen, CB; Kalluri, R; Leboy, PS; Lei, H; Strauss, JF; Wakenell, P | 1 |
| Bailey, S; Bolognese, B; Buckle, DR; Faller, A; Jackson, S; Louis-Flamberg, P; Marshall, LA; Mayer, RJ; McCord, M; Smith, DG | 2 |
| Athota, AB; Chu, WS; Colclasure, JC; Kelly, T; Osborne, RL; Rozypal, TL; Yan, Y | 1 |
| Albert, DH; Curtin, ML; Davidsen, SK; Garland, RB; Heyman, HR; Holms, JH; Hutchins, C; Li, J; Magoc, TJ; Marcotte, PA; Morgan, DW; Nagy, IB; Steinman, DH; Summers, JB | 1 |
| Bigatel, DA; Carey, DJ; Cizmeci-Smith, G; Elmore, JR; Franklin, DP; Youkey, JR | 1 |
| Rosemurgy, AS; Shafii, AE; Zervos, EE | 1 |
| Pass, MA; Pollitt, CC; Pollitt, S | 1 |
| Larjava, H; Mäkelä, M; Salo, T; Sorsa, T; Teronen, O; Uitto, VJ | 1 |
| Bouterfa, H; Hanke, A; Kerkau, S; Mueller, JG; Roosen, K; Tonn, JC; Vince, GH; Wagner, S | 1 |
| Cahill, PA; Hirsch, M; Okada, SS; Redmond, EM; Sitzmann, JV; Wang, YN | 1 |
| Albanell, J; Arribas, J; Baselga, J; Codony-Servat, J; Lopez-Talavera, JC | 1 |
| Lacalle, RA; Mañes, S; Márquez, G; Martínez-A, C; Mira, E | 1 |
| Braybrooke, JP; Brown, P; Gleeson, F; Harris, AL; Long, L; Macaulay, VM; Mason, CS; O'Byrne, KJ; Saunders, MP; Talbot, DC | 1 |
| Das, A; McGuire, PG; McLamore, A; Song, W | 1 |
| Bergers, G; Folkman, J; Hanahan, D; Javaherian, K; Lo, KM | 1 |
| Fujimori, K; Inui, T; Ishibashi, O; Kokubo, T; Nakajima, M; Origane, Y | 1 |
| Mariani, B; Poggi, A; Prontera, C; Rossi, C; Rotilio, D | 1 |
| Haq, M; Rosemurgy, AS; Shafii, AE; Zervos, EE | 1 |
| Bu, W; Li, XM; Qin, LX; Tang, ZY; Xia, JL | 1 |
| Bernard, P; Bobichon, H; Buisson-Legendre, N; Emonard, H; Haye, B; Hornebeck, W; Maquart, FX; Schneider, C | 1 |
| Chambers, AF; Groom, AC; MacDonald, IC; Morris, VL; Schmidt, EE; Varghese, HJ; Wylie, S | 1 |
| Beekman, B; Drijfhout, JW; Ronday, HK; TeKoppele, JM | 1 |
| Amour, A; Butler, M; Docherty, AJ; Hutton, M; Knäuper, V; Knight, CG; Murphy, G; Slocombe, PM; Smith, BJ; Webster, A | 1 |
| Bassano, L; D'Incalci, M; Erba, E; Giavazzi, R; Ronzoni, S | 1 |
| Aparicio, T; Dessirier, V; Kermorgant, S; Lehy, T; Lewin, MJ | 1 |
| Birembaut, P; Buisson, AC; Gilles, C; Kaplan, H; Legrand, C; Polette, M; Tournier, JM; Zahm, JM | 1 |
| Campbell, GR; Campbell, JH; Fitzgerald, M; Hayward, IP; Thomas, AC | 1 |
| Hande, KR; Nelson, AR; Rothenberg, ML | 1 |
| Atarshi, Y; Balkir, L; Gastman, BR; Rabinowich, H; Reichert, TE; Saito, T; Whiteside, TL | 1 |
| Itoh, Y; Kajita, M; Kinoh, H; Mori, H; Okada, A; Seiki, M | 1 |
| Clark, IM; Maidment, JM; Moore, D; Murphy, G; Murphy, GP | 1 |
| Bonnet, J; de Nanteuil, G; Léonce, S; Lesur, C; Pérez, V; Rolland, G; Sabatini, M; Thomas, M | 1 |
| Arzt, E; Carrizo, G; Chervín, A; Goldberg, V; Ledda, MF; Molina, H; Müller, A; Páez Pereda, M; Podhajcer, O; Renner, U; Stalla, GK | 1 |
| Erfle, V; Fontana, A; Koedel, U; Kohleisen, B; Paul, R; Pfister, HW; Sporer, B | 1 |
| Ismair, MG; Liu, H; Petrides, PE; Ries, C; Zang, C | 1 |
| Grinberg, S; James, PE; O'Hara, JA; Panz, T; Swartz, HM | 1 |
| Chuang, N; Galloway, AC; Marcus, SG; Mignatti, P; Monea, S; Pocock, BJ; Schwartz, JD; Shamamian, P; Whiting, D | 1 |
| Borchert, D; Hasan, T; Jung, K; Le, DK; Lein, M; Loenings, SA; Ortel, B; Schnorr, D; Winkelmann, B | 1 |
| Antoniu, BA; Compton, CC; Fernández-Del Castillo, C; Hartwig, W; Jimenez, RE; Warshaw, AL | 1 |
| Nakajima, M | 1 |
| Escalante, T; Franceschi, A; Gutiérrez, JM; Rucavado, A | 1 |
| Hooper, NM; Parkin, ET; Trew, AJ; Turner, AJ | 1 |
| Allen, E; Hotary, K; Punturieri, A; Weiss, SJ; Yana, I | 1 |
| Haq, M; Rosemurgy, AS; Shafii, A; Zervos, EE | 1 |
| Borst, C; de Kleijn, D; de Smet, BJ; Hanemaaijer, R; Post, MJ; Robertus, L; van Der Helm, YJ; Verheijen, JH | 1 |
| Bresolin, MD; Caron, NJ; El Fahime, E; Torrente, Y; Tremblay, JP | 1 |
| Albini, A; Buglioni, S; Ferrari, N; Ghiorzo, F; Morini, M; Mortarini, R; Mottolese, M; Natali, PG; Noonan, DM | 1 |
| Campbell, CA; Chapman, GA; Harrison, D; Moores, K; Stewart, BR; Strijbos, PJ | 1 |
| Abraham, JA; Clowes, AW; Daum, G; Kalmes, A; Vesti, BR | 1 |
| Inoue, T; Itoh, Y; Koono, M; Nabeshima, K; Okada, Y; Seiki, M; Shimao, Y | 1 |
| Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ | 1 |
| Baragi, VM; Cohen, JR; Kuipers, PJ; Mathrubutham, M; Rao, SK; Renkiewicz, RR; Shaw, BJ; Welgus, HG | 1 |
| Briganti, F; Mincione, G; Scozzafava, A; Supuran, CT | 1 |
| Aza-Blanc, P; Kornberg, TB; Llano, E; López-Otín, C; Pendás, AM | 1 |
| Arriaga, K; Hernandez-Pando, R; Orozco, H; Pavön, L; Rook, G | 1 |
| Hwang, JJ; Ip, MM; Lee, PP; Murphy, G | 1 |
| Fujieda, A; Ikeda, T; Kawaguchi, H; Nagai, Y; Obara, K; Shima, M; Shimoaka, T; Suzuki, H; Uchida, M; Yamato, H | 1 |
| Elalamy, I; Hatmi, M; Kazes, I; Nguyen, G; Sraer, JD | 1 |
| Balkwill, FR; Dias, S; Holdsworth, H; Scott, KA | 1 |
| Chapman, DF; Lapchak, PA; Zivin, JA | 1 |
| Esposito, B; Lehoux, S; Mallat, Z; Tedgui, A; Tronc, F; Wassef, M | 1 |
| Lohi, J; Parks, WC; Roby, JD; Wilson, CL | 1 |
| Asahi, K; Asahi, M; del Zoppo, GJ; Fini, ME; Jung, JC; Lo, EH | 1 |
| Ergul, A; Grubbs, AL; Spinale, FG; Zhang, Y | 1 |
| Eckhardt, SG; Hidalgo, M | 1 |
| Bone, E; Lee, J; Mejia, S; Orr, W; Watson, P; Weber, M | 1 |
| Gretz, N; Kränzlin, B; Morente, N; Obermüller, N; Witzgall, R | 1 |
| Gu, B; Li, M; Lü, H; Wu, D | 1 |
| Kyaw-Tanner, M; Mungall, BA; Pollitt, CC | 1 |
| Arlt, M; Gänsbacher, B; Harbeck, N; Kopitz, C; Krüger, A; Magdolen, V; Schmitt, M; Soeltl, R; Sopov, I | 1 |
| Birembaut, P; de Bentzmann, S; Huet, E; Legrand, C; Monteau, M; Polette, M; Tournier, JM | 1 |
| Alfalah, M; Hooper, NM; Jacob, R; Mentele, R; Naim, HY; Parkin, ET; Sturrock, ED; Turner, AJ | 1 |
| Boichot, E; Caulet-Maugendre, S; Corbel, M; Germain, N; Lagente, V; Molet, S | 1 |
| Howard, RB; Johnston, MR; Mullen, JB; Pagura, ME | 1 |
| Blasi, F; Hanemaaijer, R; Koolwijk, P; Peters, E; Sidenius, N; Sier, CF; van Hinsbergh, VW | 1 |
| Chiba, T; Itoh, Y; Kajita, M; Kinoh, H; Mori, H; Okada, A; Seiki, M | 1 |
| Hwang, JJ; Ip, MM; Lee, PP; Mead, L | 1 |
| Albanell, J; Arribas, J; Baselga, J; Codony-Servat, J; Molina, MA; Rojo, F | 1 |
| Andhyiswara, I; Borst, C; de Kleijn, D; de Smet, BJ; Kloet, J; Krams, R; Oomen, JA; Pasterkamp, G; Post, MJ; Schuurbiers, JC; Slager, CJ; Wentzel, JJ | 1 |
| Artese, L; di Mola, FF; Di Sebastiano, P; Innocenti, P; Mascetta, G; Pernthaler, H; Rossi, C | 1 |
| Duriez, M; Levy, BI; Mallat, Z; Silvestre, JS; Tamarat, R; Tedgui, A | 1 |
| Feldman, AM; Li, YY | 1 |
| Clowes, AW; Hasenstab, D; Kenagy, RD; Li, ZY; Lieber, A; Shofuda, KI; Shofuda, T | 1 |
| Bouloumié, A; Galitzky, J; Lafontan, M; Portolan, G; Sengenès, C | 1 |
| Boichot, E; Corbel, M; Germain, N; Lagente, V; Lanchou, J; Malledant, Y | 1 |
| Bode, W; Braun, M; Huber, R; Kocourek, A; Lang, R; Maskos, K; Tschesche, H | 1 |
| Cawston, TE; Elliott, SF; Milner, JM | 1 |
| Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E | 1 |
| Itoh, T; Itohara, S; Lannoy, K; Libert, C; Shapiro, SD; Vandekerckhove, J; Wielockx, B | 1 |
| Mao, L; Sun, K; Yu, S | 1 |
| Brünner, N; Carmeliet, P; Dickson, RB; Frandsen, TL; Holst-Hansen, C; Johnson, MD; Low, JA; Stephens, RW | 1 |
| Anderson, RL; Bissell, MJ; Le Beyec, J | 1 |
| Bhagat, S; Che, M; Cher, ML; Fridman, R; Herzog, M; Mullins, C; Nemeth, JA; Shekarriz, B; Upadhyay, J; Yousif, R | 1 |
| Ala-Aho, R; Baker, AH; Johansson, N; Kähäri, VM | 1 |
| Antoniu, BA; Balcom, JH; Fernández-del Castillo, C; Keck, T; Warshaw, AL | 1 |
| Mungall, BA; Pollitt, CC | 1 |
| Anderson, MS; Boice, JA; Fletcher, AM; Ronan, J; Stiffey-Wilusz, J | 1 |
| Feldman, AM; Kadokami, T; Li, YY; McTiernan, CF; Wang, P | 1 |
| Colige, A; Devy, L; Foidart, JM; Garnotel, R; Hollender, P; Jeannesson, P; Munaut, C; Noël, A | 1 |
| Calderon-Ramirez, L; Frösen, J; Häyry, P; Myllärniemi, M | 1 |
| Lo, EH; Sumii, T | 1 |
| Chabot, S; Hirashima, M; Kashio, Y; Matsumoto, R; Nakamura, K; Nakamura, T; Nishi, N; Seki, M; Shirato, Y | 1 |
| Vogel, WF | 1 |
| Chatterjee, M; De Angelis, T; Mulholland, J; Noè, A | 1 |
| Capdevila, J; Chen, JK; Harris, RC | 1 |
| Banai, S; Fishbein, I; Gertz, SD; Golomb, G; Margolin, L; Perez, LS; Reich, R | 1 |
| Andersen, TL; Brünner, N; Delaissé, JM; Foged, NT; Heegaard, AM; Holst-Hansen, C; Høegh-Andersen, P; Misander, H; NicAmhlaoibh, R; Winding, B | 1 |
| Diaz, C; Escalante, T; Fernándes, CM; Gutiérrez, JM; Rucavado, A; Teixeira, CF | 1 |
| Enrich, C; Lladó, A; Tebar, F | 1 |
| Chen, X; Lin, H; Wang, J; Yu, Z | 1 |
| Falk, V; Grünenfelder, J; Hoyt, G; Robbins, RC; Soccal, PM; Walther, T | 1 |
| Bailly, V; Bonventre, JV; Cate, R; Meier, W; Sanicola, M; Zhang, Z | 1 |
| Beher, D; Owens, AP; Shearman, MS; Wrigley, JD | 1 |
| de Hingh, IH; de Man, BM; Hendriks, T; Lomme, RM; Siemonsma, MA | 1 |
| Hocking, JC; McFarlane, S; Stange, CL; Webber, CA; Yong, VW | 1 |
| Herse, B; Mirzaie, M; Oster, O; Schöndube, F | 1 |
| Collen, A; Grimbergen, J; Hanemaaijer, R; Koolwijk, P; Lupu, F; Peters, E; Quax, PH; van Hinsbergh, VW; van Lent, N | 1 |
| Bernard, J; Eymard, JC; Hollender, P; Ittelett, D; Jeannesson, P; Villard, F | 1 |
| Napoli, C | 1 |
| Anglard, P; Bonnafous, S; Chavey, C; Mari, B; Monthouel, MN; Tartare-Deckert, S; Van Obberghen, E | 1 |
| Augustin, HG | 1 |
| Bayliss, MT; Bird, JL; Mason, RM; Sugimoto, K; Yasumoto, T | 1 |
| Buhr, HJ; Foitzik, T; Hines, OJ; Hotz, B; Hotz, HG; Reber, HA | 1 |
| Cambrey, AD; Daniels, JT; Garrett, Q; Khaw, PT; Occleston, NL; Schultz, GS; Tarnuzzer, RW | 1 |
| Marcus, S; Muhs, BE; Patel, S; Shamamian, P; Yee, H | 1 |
| Bibova, J; Hampl, V; Herget, J; Novotna, J; Povysilova, V; Vankova, M | 1 |
| Auberger, P; Hofman, P; Le'Negrate, G; Rossi, B; Rostagno, P | 1 |
| Auberger, P; Belhacène, N; Fromigué, O; Loubat, A; Louis, K; Mari, B; Shipp, M; Wu, E | 1 |
| Pfefferkorn, T; Rosenberg, GA | 1 |
| Bergers, G; Hanahan, D | 1 |
| Casas-González, P; García-Sáinz, JA; Ruiz-Martínez, A | 1 |
| Gao, H; Gu, B; Li, M; Lü, H; Wan, Y; Wu, D | 1 |
| Cunningham, LA; Rosenberg, GA; Wetzel, M | 1 |
| Belotti, D; Garofalo, A; Giavazzi, R; Manenti, L; Marchini, S; Paganoni, P; Taraboletti, G | 1 |
| Chen, BH; Fang, SG; Gao, Y; Jiang, ZS; Liu, J; Sun, EW; Zhang, Z | 1 |
| Ciaramella, A; Fraziano, M; Mattei, M; Santucci, MB; Sumerska, T | 1 |
| Escalante, T; Gutiérrez, JM; Moura da Silva, AM; Núñez, J; Rucavado, A; Theakston, RD | 1 |
| Ingersoll, EP; McDonald, KL; Wilt, FH | 1 |
| Anderson, C; Conant, K; Gary, D; Haughey, N; Nagase, H; Nath, A; St Hillaire, C; Turchan, J; Visse, R | 1 |
| Lee, SR; Lo, EH; Tsuji, K | 1 |
| Bode, W; Braun, M; Foidart, JM; Frankenne, F; Lang, R; Maskos, K; Noel, A; Sounni, NE | 1 |
| Blobel, CP; Hartmann, D; Higashiyama, S; Kelly, K; Peschon, J; Saftig, P; Sahin, U; Weskamp, G; Zhou, HM | 1 |
| Ferguson, TA; Haskova, Z; Pan, F; Plambeck, S; Stuart, PM; Yin, X | 1 |
| Escalante, T; Gutiérrez, JM; Rucavado, A | 1 |
| Buesa, JM; de Buitrago, GG; Gómez-Moutón, C; Jiménez-Baranda, S; Lacalle, RA; Mañes, S; Martínez-A, C; Mira, E | 1 |
| El Fahime, E; Lafreniere, JF; Mills, P; Tremblay, JP | 1 |
| Björnsson, MJ; Havemose-Poulsen, A; Holmstrup, P; Stoltze, K | 1 |
| Devy, L; Foidart, JM; Frankenne, F; Grams, F; Krell, HW; Maquoi, E; Noël, A; Olivier, F; Sounni, NE | 1 |
| Bishop, NJ; Buttle, DJ; Grabowski, PS; Holmes, SG; Still, K | 1 |
| Barki-Harrington, L; El-Shewy, HM; Kelly, FL; Luttrell, LM | 1 |
| Augé, N; Elbaz, M; Itohara, S; Krell, HW; Maupas-Schwalm, F; Nègre-Salvayre, A; Salvayre, R; Thiers, JC; Waysbort, A | 1 |
| Eisinger, DA; Schulz, R; Wehmeyer, A | 1 |
| Hunt, SR; Lewis, AL; O'byrne, V; Small, SA; Stratford, PW; Willis, SL | 1 |
| Izzo, AA; Izzo, LS; Kasimos, J; Majka, S | 1 |
| Bouloumié, A; Bourlier, V; De Barros, S; de Saint Front, VD; Galitzky, J; Lafontan, M; Pizzacalla, C; Zakaroff-Girard, A | 1 |
| Brenes, O; Díaz, C; Gutiérrez, JM; Rucavado, A; Valverde, L | 1 |
| Carter, KJ; Fingleton, B; Hachey, DL; Matrisian, LM; McIntyre, JO; Menon, R; Overstreet, PD | 1 |
| Didziapetriene, J; Kadziauskas, J; Stanciūte, D | 1 |
| Aoki, T; Li, Y; Miyamori, H; Sato, D; Sato, H; Takino, T | 1 |
| Choi, C; Clowes, AW; Colige, A; Defawe, OD; Deroanne, C; Kenagy, RD; Nusgens, B; Sakalihasan, N; Wan, SY | 1 |
| Araujo, CM; Cristóvão, SA; Mangione, JA; Mauro, MF; Oliveira Neto, JB; Rando, GA; Salman, AA; Sanchez, IS | 1 |
| Kaitu'u, TJ; Morison, NB; Salamonsen, LA; Shen, J; Zhang, J | 1 |
| Agamennone, M; Biasone, A; Campestre, C; Consalvi, V; Gallina, C; Gavuzzo, E; Hiller, O; Mazza, F; Pochetti, G; Preziuso, S; Tortorella, P; Tschesche, H | 1 |
| Golub, LM; Sorsa, T | 1 |
| Carey, DJ; DiPino, F; Heitzman, D; Prentiss, L; Stahl, RC; Zhang, Z | 1 |
| Armstrong, C; Durkin, AJ; Osborne, DA; Rosemurgy, AS; Yeatman, TJ; Zervos, EE | 1 |
| Casas-González, P; García-Sáinz, JA | 1 |
| Maskos, K; Opdenakker, G; Pagenstecher, A; Starckx, S; Van Aelst, I; Van den Steen, PE | 1 |
| Dubrovskaya, NM; Nalivaeva, NN; Turner, AJ; Zhuravin, IA | 1 |
| Buist, R; Owens, T; Peeling, J; Schellenberg, A; Sun, XJ; Toft-Hansen, H | 1 |
| Foda, H; Hymowitz, M; Montana, S; Rollo, EE; Schmidt, CE; Zucker, S | 1 |
| Baumann, U; García-Castellanos, R; Gomis-Rüth, FX; Marrero, A; Solà, M; Tallant, C | 1 |
| Estrada, EY; Mobashery, S; Rosenberg, GA | 1 |
| Godlewski, A; Meleń-Mucha, G; Mucha, SA; Stepień, H | 1 |
| Chu, P; Hamada, H; Kato, K; Kipps, TJ; Takahashi, S | 1 |
| Aoki, T; Katsuki, M; Nakamura, K; Nakao, K; Sagara, H; Sato, H; Seiki, M; Takaki, S; Takatsu, K; Taniguchi, S; Weiss, SJ; Yana, I | 1 |
| Gao, SJ; Qian, LW; Xie, J; Ye, F | 1 |
| Auge, N; Coatrieux, C; Hannun, Y; Itohara, S; Negre-Salvayre, A; Parini, A; Salvayre, R; Sanson, M | 1 |
| DeGroot, J; Hanemaaijer, R; Huizinga, TW; Kraan, MC; Tchetverikov, I; van El, B | 1 |
| Libert, C; López-Otin, C; Shapiro, S; Van Laere, I; Van Lint, P; Van Roy, M; Wielockx, B; Wilson, C | 1 |
| Grossetete, M; Rosenberg, GA | 1 |
| Kudo, T; Miyamori, H; Saeki, H; Sato, H; Takino, T | 1 |
| Burdon, PC; Martin, C; Rankin, SM | 1 |
| Ayscough, A; Bawden, LJ; Bone, EA; Box, G; Callaghan, J; Chandler, S; Clark, VL; Drummond, AH; Eccles, SA; Farmer, H; Flores, N; Kirwin-Jones, P; Krige, D; Laber, D; Legris, V; Miles, LE; Needham, LA; Odedra, R; Owen, J; Patel, T; Stone, E; Wood, LM; Wood, S; Wright, A | 1 |
| Fu, J; Herrlich, A; Klinman, E; Lodish, H; Sadegh, C | 1 |
| Bildt, MM; Bloemen, M; Kuijpers-Jagtman, AM; Von den Hoff, JW | 1 |
| Goldman, SJ; Kasaian, MT; Margulis, A; Nocka, KH; Wolf, SF; Wood, NL | 1 |
| Agüera-González, S; Atkinson, S; Boutet, P; Edwards, DR; Murphy, G; Pennington, CJ; Reyburn, HT; Valés-Gómez, M | 1 |
| Rosenberg, GA; Walker, EJ | 2 |
| Dobschütz, EV; Hopt, U; Keck, T; Mikami, Y; Sommer, O; Unno, M; Wellner, U | 1 |
| Sakamoto, T; Seiki, M | 1 |
| George, SJ; Jackson, CL; Johnson, JL; White, SJ; Williams, H | 1 |
| Feng, JB; Ge, SL; Gong, WH; Han, PH; Zhang, CX; Zhang, L; Zhang, SQ; Zhou, DC | 1 |
| Bhatnagar, S; Kumar, A | 1 |
| Domoto, T; Nakano, H; Nakanuma, Y; Sakr, MA; Sasaki, M; Sato, H; Takino, T; Wong, RW | 1 |
| Ali, MI; Anea, CB; Merloiu, AM; Osmond, JM; Rudic, RD; Stepp, DW; Sullivan, JC | 1 |
| Escalante, T; Fox, JW; Gutiérrez, JM; Rucavado, A; Shannon, J | 1 |
| Adrain, C; Freeman, M; Hu, L; Lemberg, MK; Strisovsky, K; Zettl, M | 1 |
| Cho, SH; Duin, EC; Hong, JW; Jambovane, S; Kim, SK; Yun, JY | 1 |
| Corvol, P; English, WR; Murphy, G | 1 |
| Guo, P; He, H; Tseng, SC; Zhang, SZ; Zhu, YT | 1 |
| Almahdy, A; Banerjee, A; Bartsch, JW; Koller, G; Sauro, S; Sherriff, M; Watson, TF | 1 |
| Caspers, N; Chrencik, JE; Day, JE; Fischer, DH; Hall, T; Kiefer, JR; Krahn, JM; Moon, AF; Pauley, AM; Pegg, LE; Shieh, HS; Tomasselli, AG; Williams, JM; Zack, MD | 1 |
| Domoto, T; Endo, Y; Guo, L; Sato, H; Takino, T | 1 |
| Chen, QF; Li, D; Wang, HB; Wang, L; Wang, Y | 1 |
| Cayabyab, FS; Gowribai, K; Walz, W | 1 |
| Alemi, F; Bunnett, NW; Canals, M; Corvera, CU; Cottrell, GS; Godfrey, CB; Jensen, DD; Kocan, M; Korbmacher, C; Lambert, NA; Murphy, JE; Niklas, C; Poole, DP | 1 |
| Padmanabhan, J; Woods, NK | 1 |
| Dong, Q; Jiao, XL; Zhang, DL; Zhang, J | 1 |
| Copple, BL; Fickert, P; Jaeschke, H; Ramachandran, A; Trauner, M; Woolbright, BL; Yan, HM; Yang, M | 1 |
| Cho-Clark, M; Larco, DO; Mani, SK; Semsarzadeh, NN; Vasta, F; Wu, TJ | 1 |
| Antelmi, E; Busco, G; Cardone, RA; Casavola, V; Greco, MR; Guerra, L; Reshkin, SJ; Rubino, R | 1 |
| Petroll, WM; Zhou, C | 1 |
| Sun, PD; Wang, R | 1 |
| Wang, M; Xiao, L | 1 |
| Bilic, J; Blaschitz, A; Desoye, G; Gauster, M; Huppertz, B; Kremshofer, J; Siwetz, M | 1 |
| Altevogt, P; Arnold, A; Cerwenka, A; Fiegler, N; Moldenhauer, G; Paschen, A; Rose-John, S; Schlecker, E; Sucker, A; Textor, S; von Strandmann, EP | 1 |
| Kirkegaard, T; Kveiborg, M; Lykkesfeldt, AE; Yde, CW | 1 |
| Cummins, N; Dabo, AJ; Foronjy, RF; Geraghty, P; Taggart, CC; Weldon, S | 1 |
| Geraghty, NJ; Pupovac, A; Sluyter, R; Watson, D | 1 |
| Bu, S; Cai, X; Cao, C; Cheng, J; Li, H; Liu, J; Peng, C; Tan, H; Wang, K; Zhang, J; Zhu, Y | 1 |
| Braccini, T; Grandgirard, D; Koedel, U; Leib, SL; Oggioni, MR; Ricci, S; Salvatore, P; Wenzel, M | 1 |
| Almahdy, A; Banerjee, A; Bartsch, JW; Festy, F; Koller, G; Watson, TF | 1 |
| Carsten, CG; Chowdhury, A; Gerard, P; Gray, BH; Nahar-Gohad, P; Nosoudi, N; Sinha, A; Vyavahare, NR | 1 |
| He, Q; Liu, D; Liu, G; Wang, B; Wang, Q; Zhang, L; Zhang, X; Zheng, J; Zhou, Y | 1 |
| Chen, AC; Kim, S; Leriche, G; Selkoe, DJ; Yang, J | 1 |
| Babayan, AH; Gall, CM; Hou, B; Kantorovich, S; Lynch, G; Wang, W | 1 |
| Arias, AS; Gutiérrez, JM; Herrera, M; León, G; Rivel, M; Segura, Á; Solano, D; Vargas, M; Villalta, M | 1 |
| Adekoya, OA; Jayaram, B; Singh, T | 1 |
| Annis, DS; Bortnov, V; Johansson, MW; Khanna, M; Mosher, DF; Nguyen, CL | 1 |
| Arias, AS; Gutiérrez, JM; Rucavado, A | 1 |
| Cayabyab, FS; Walz, W | 1 |
| Arthos, J; Chastain, A; Chun, TW; Fischer, E; He, B; Holzapfel, G; Ireland, J; Kano, D; Kononchik, J; Moir, S; Segura, J; Spencer, M; Stutzman, N; Sun, P; Wang, R; Zou, Z | 1 |
| Bellard, E; Belozertseva, E; Ben-Neji, M; Dalenc, F; Franchet, C; Gilhodes, J; Golzio, M; Gui, P; Labrousse, A; Le Cabec, V; Maridonneau-Parini, I; Poincloux, R | 1 |
| Defour, A; Diaz Manera, J; Gallardo, E; Hogarth, MW; Jaiswal, JK; Lazarski, C; Nagaraju, K; Partridge, TA | 1 |
| Amaral, CM; Bezerra, RDSG; da Silva, EM; Miranda, MEDSNG; Noronha Filho, JD; Simmer, FS | 1 |
| Bahraini, E; Biranvand, AS; Esfandiari, G; Fattahi, F; Ghasempour, G; Kakavandi, N; Khosravi, M; Najafi, M; Poursaleh, A | 1 |
| Bicknell, AB; Lakshminarayanan, K; Layfield, HJ; Mehmi, A; Patel, K; Ravishankar, D; Salim, A; Sonavane, M; Trim, SA; Vaiyapuri, R; Vaiyapuri, S; Vallance, TM; Williams, HF | 1 |
| Dharmasivam, M; Park, KC; Richardson, DR | 1 |
| Lin, IT; Lin, MY; Wang, IJ; Wu, YC | 1 |
16 review(s) available for phenylalanine and batimastat
| Article | Year |
|---|---|
Clinical trials of a low molecular weight matrix metalloproteinase inhibitor in cancer.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Female; Humans; Metalloendopeptidases; Mice; Mice, Nude; Ovarian Neoplasms; Phenylalanine; Thiophenes; Transplantation, Heterologous | 1994 |
Matrix metalloproteinase inhibition: a review of anti-tumour activity.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Humans; Melanoma, Experimental; Metalloendopeptidases; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Thiophenes | 1995 |
[Development of anti tumor agents targeting angiogenesis].
Topics: Antineoplastic Agents; Clinical Trials as Topic; Cyclohexanes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Interferon-alpha; Interleukin-12; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Platelet Factor 4; Polysaccharides, Bacterial; Sesquiterpenes; Thalidomide; Thiophenes; Triazines; Triazoles; Tumor Cells, Cultured | 1997 |
Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Ascites; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Extracellular Matrix; Female; Humans; Male; Metalloendopeptidases; Mice; Middle Aged; Neoplasms; Phenylalanine; Pleural Effusion, Malignant; Protease Inhibitors; Rats; Thiophenes | 1996 |
Matrix metalloproteinase inhibitors.
Topics: Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Down-Regulation; Drugs, Investigational; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Hydroxamic Acids; Metalloendopeptidases; Molecular Weight; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Protein Kinase C; Proteins; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases | 1997 |
Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Enzyme Inhibitors; Female; Hemangioma; Humans; Hydroxamic Acids; Melanoma; Metalloendopeptidases; Mice; Ovarian Neoplasms; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Skin Neoplasms; Thiophenes | 1997 |
Matrix metalloproteinase inhibitors: present achievements and future prospects.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Enzyme Inhibitors; Extracellular Matrix; Humans; Hydroxamic Acids; Metalloendopeptidases; Neoplasm Metastasis; Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes | 1997 |
[Neovascularization and tumor development].
Topics: Angiostatins; Antibiotics, Antineoplastic; Antineoplastic Agents; Collagen; Cyclohexanes; Endostatins; Humans; Hydroxamic Acids; Interferons; Interleukin-12; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Peptide Fragments; Phenylalanine; Plasminogen; Sesquiterpenes; Thalidomide; Thiophenes | 1998 |
[Matrix metalloproteinase inhibitors].
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Design; Humans; Hydroxamic Acids; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Metastasis; Organic Chemicals; Phenylalanine; Thiophenes | 2000 |
The role of proteolysis in Alzheimer's disease.
Topics: ADAM Proteins; ADAM17 Protein; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biotinylation; Endopeptidases; Humans; Hydroxamic Acids; Membrane Lipids; Membrane Proteins; Metalloendopeptidases; Nerve Tissue Proteins; Phenylalanine; Presenilin-1; Presenilin-2; Protease Inhibitors; Rats; Thiophenes | 2000 |
Development of matrix metalloproteinase inhibitors in cancer therapy.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Biphenyl Compounds; Clinical Trials as Topic; Drugs, Investigational; Enzyme Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Neoplasms; Organic Chemicals; Phenylalanine; Phenylbutyrates; Protease Inhibitors; Pyrazines; Sulfonamides; Tetracycline; Tetracyclines; Thiophenes | 2001 |
Matrix metalloproteinases in the progression of heart failure: potential therapeutic implications.
Topics: Animals; Enzyme Inhibitors; Extracellular Matrix; Heart Failure; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Myocardium; Phenylalanine; Thiophenes | 2001 |
[Angiogenesis research--quo vadis?].
Topics: Adult; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Bevacizumab; Cell Communication; Drug Evaluation, Preclinical; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ephrins; Forecasting; Growth Substances; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Lymphokines; Metalloendopeptidases; Mice; Neoplasms; Neovascularization, Pathologic; Neovascularization, Physiologic; Phenylalanine; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor; Research; Signal Transduction; Thalidomide; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
[Expression of matrix metalloproteinases in patients with malignant tumors].
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Clinical Trials as Topic; Diphosphonates; Disease Progression; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasms; Organic Chemicals; Phenylalanine; Phenylbutyrates; Prognosis; Protease Inhibitors; Thiophenes; Time Factors; Tissue Inhibitor of Metalloproteinases | 2004 |
Neutrophil Infiltration and Matrix Metalloproteinase-9 in Lacunar Infarction.
Topics: Animals; Humans; Matrix Metalloproteinase 9; Neutrophil Infiltration; Phenylalanine; Protease Inhibitors; Rats; Stroke, Lacunar; Thiophenes | 2017 |
The Role of Extracellular Proteases in Tumor Progression and the Development of Innovative Metal Ion Chelators that Inhibit their Activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Transformation, Neoplastic; Chelating Agents; Disease Progression; Drug Design; Drug Screening Assays, Antitumor; Extracellular Fluid; Extracellular Vesicles; Humans; Hydroxamic Acids; Iron; Iron Chelating Agents; Kallikreins; Matrix Metalloproteinases; Molecular Targeted Therapy; Neoplasm Proteins; Oxaprozin; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Protein Kinases; Pyridines; Thiophenes; Thiosemicarbazones; Zinc | 2020 |
6 trial(s) available for phenylalanine and batimastat
| Article | Year |
|---|---|
Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer.
Topics: Adult; Aged; Antineoplastic Agents; Collagenases; Drug Administration Schedule; Female; Gelatinases; Humans; Injections, Intraperitoneal; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Middle Aged; Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes | 1996 |
Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites.
Topics: Aged; Antineoplastic Agents; Ascites; Gastrointestinal Neoplasms; Humans; Infusions, Parenteral; Metalloendopeptidases; Middle Aged; Phenylalanine; Protease Inhibitors; Thiophenes; Treatment Outcome | 1997 |
Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Ascites; Dose-Response Relationship, Drug; Female; Humans; Male; Metalloendopeptidases; Middle Aged; Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes | 1998 |
Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions.
Topics: Adult; Aged; Antineoplastic Agents; Enzyme Inhibitors; Female; Humans; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Middle Aged; Outcome Assessment, Health Care; Phenylalanine; Pleural Effusion, Malignant; Thiophenes | 1999 |
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.
Topics: Aged; alpha-Macroglobulins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Down-Regulation; Enzyme Inhibitors; Female; Humans; Isoxazoles; Leflunomide; Male; Matrix Metalloproteinases; Methotrexate; Middle Aged; Multiprotein Complexes; Phenylalanine; Statistics, Nonparametric; Thiophenes | 2008 |
S100A4 regulates migration and invasion in hepatocellular carcinoma HepG2 cells via NF-κB-dependent MMP-9 signal.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Movement; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phenylalanine; Pyrrolidines; RNA, Small Interfering; S100 Calcium-Binding Protein A4; S100 Proteins; Thiocarbamates; Thiophenes; Transcription Factor RelA; Transfection | 2013 |
286 other study(ies) available for phenylalanine and batimastat
| Article | Year |
|---|---|
Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hemangioendothelioma; Metalloendopeptidases; Mice; Neoplasm Invasiveness; Neovascularization, Pathologic; Phenylalanine; Thiophenes; Time Factors | 1995 |
The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism.
Topics: Animals; Aorta; Doxycycline; Gelatinases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Minocycline; Neoplasm Proteins; Neovascularization, Pathologic; Phenylalanine; Rats; Rats, Inbred F344; Thiophenes | 1995 |
Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice.
Topics: Animals; Breast Neoplasms; Chemotherapy, Adjuvant; Chi-Square Distribution; Collagenases; Female; Humans; Linear Models; Lung Neoplasms; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Recurrence, Local; Neoplasm Transplantation; Phenylalanine; RNA, Messenger; RNA, Neoplasm; Thiophenes; Tumor Cells, Cultured | 1995 |
Matrix metalloproteinase inhibitors: a novel class of anticancer agents.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Humans; Melanoma, Experimental; Metalloendopeptidases; Mice; Mice, Inbred Strains; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes | 1995 |
Interleukin-1 and oncostatin M in combination promote the release of collagen fragments from bovine nasal cartilage in culture.
Topics: Animals; Cartilage; Cattle; Collagen; Glycoproteins; Glycosaminoglycans; Interleukin-1; Kinetics; Metalloendopeptidases; Nose; Oncostatin M; Peptides; Phenylalanine; Protease Inhibitors; Proteoglycans; Thiophenes; Tissue Inhibitor of Metalloproteinases | 1995 |
Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
Topics: Amino Acid Sequence; Collagenases; Crystallography, X-Ray; Humans; Hydroxamic Acids; Matrix Metalloproteinase 8; Molecular Sequence Data; Phenylalanine; Protein Conformation; Stereoisomerism; Thiophenes | 1995 |
Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.
Topics: Animals; Carcinoma; Cell Division; Colorectal Neoplasms; Humans; In Vitro Techniques; Male; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phenylalanine; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured | 1995 |
Preclinical antiarthritic activity of matrix metalloproteinase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Indomethacin; Inflammation; Isomerism; Metalloendopeptidases; Phenylalanine; Radiography; Rats; Thiophenes; Time Factors | 1994 |
Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Melanoma, Experimental; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phenylalanine; Thiophenes; Tissue Distribution | 1994 |
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.
Topics: Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Humans; Male; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Thiophenes; Transplantation, Heterologous | 1994 |
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation.
Topics: Aggrecans; Amino Acid Sequence; Animals; Cartilage; Cartilage, Articular; Cathepsin B; Cattle; Dipeptides; Enzyme Activation; Extracellular Matrix Proteins; Interleukin-1; Lectins, C-Type; Metalloendopeptidases; Molecular Sequence Data; Nasal Septum; Peptide Fragments; Phenylalanine; Proteoglycans; Recombinant Proteins; Thiophenes; Tretinoin | 1993 |
A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.
Topics: Aged; Animals; Carcinoma; Cell Division; Extracellular Matrix; Female; Humans; In Vitro Techniques; Metalloendopeptidases; Mice; Molecular Structure; Neoplasm Transplantation; Ovarian Neoplasms; Phenylalanine; Survival Analysis; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured | 1993 |
Degradation of bovine cartilage proteoglycan in vitro is enhanced by inhibition of nitric oxide synthase.
Topics: Animals; Arginine; Cartilage; Cattle; Enzyme Inhibitors; Glycosaminoglycans; In Vitro Techniques; Indicators and Reagents; Interleukin-1; Metalloendopeptidases; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylalanine; Protease Inhibitors; Proteoglycans; Thiophenes | 1995 |
Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor.
Topics: Animals; Aorta; Carotid Artery Injuries; Catheterization; Cell Division; Cell Movement; Cells, Cultured; Male; Metalloendopeptidases; Muscle, Smooth, Vascular; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Thiophenes | 1996 |
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Conserved Sequence; Crystallography, X-Ray; Fourier Analysis; Metalloendopeptidases; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Protein Structure, Secondary; Thiophenes | 1996 |
Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase.
Topics: Animals; Cells, Cultured; Chlorocebus aethiops; Collagenases; Enzyme Activation; Gelatinases; Glycoproteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Protein Precursors; Protein Processing, Post-Translational; Proteins; Recombinant Fusion Proteins; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinases | 1996 |
Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Gelatinases; Lung Neoplasms; Mammary Neoplasms, Animal; Matrix Metalloproteinase 2; Metalloendopeptidases; Neoplasm Metastasis; Phenylalanine; Rats; Specific Pathogen-Free Organisms; Survival Rate; Thiophenes | 1996 |
Tumor necrosis factor-alpha-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window.
Topics: Animals; Blood-Brain Barrier; Collagenases; Dose-Response Relationship, Drug; Enzyme Induction; Injections, Intraventricular; Male; Matrix Metalloproteinase 9; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors; Tumor Necrosis Factor-alpha | 1995 |
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2.
Topics: Arginine; Binding Sites; Enzyme Activation; Enzyme Precursors; Furin; Gelatinases; Glycoproteins; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Proteins; Recombinant Fusion Proteins; Subtilisins; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinases; Tyrosine | 1996 |
Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Humans; Metalloendopeptidases; Mice; Mice, SCID; Phenylalanine; Thiophenes; Tumor Cells, Cultured | 1996 |
Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice.
Topics: Animals; Antineoplastic Agents; Burkitt Lymphoma; DNA; DNA, Neoplasm; Humans; Mice; Mice, SCID; Phenylalanine; Species Specificity; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-gamma in a human salivary gland cell line.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Blotting, Northern; Cell Division; Cell Line; Collagenases; Epithelial Cells; Epithelium; Gelatinases; Humans; Interferon-gamma; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Mice; Parotid Gland; Phenylalanine; Protease Inhibitors; Receptors, Interferon; RNA, Messenger; Saliva; Sjogren's Syndrome; Thiophenes; Tumor Necrosis Factor-alpha | 1997 |
Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.
Topics: Animals; Breast; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cell Line; Cell Movement; Cell Size; Collagenases; Epithelial Cells; Epithelium; Extracellular Matrix; Female; Fibrinolysin; Gelatinases; Humans; Kalinin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Mice; Phenylalanine; Protease Inhibitors; Rats; Recombinant Fusion Proteins; Skin Neoplasms; Thiophenes | 1997 |
Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo.
Topics: Animals; Humans; Metalloendopeptidases; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes; Tumor Cells, Cultured | 1997 |
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile.
Topics: Collagenases; Crystallography; Drug Design; Humans; Hydrogen Bonding; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Neutrophils; Peptide Fragments; Phenylalanine; Protease Inhibitors; Thiophenes | 1997 |
Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Cell Polarity; Dogs; Epidermal Growth Factor; Extracellular Space; Humans; Hydrolysis; Kidney; Metalloendopeptidases; Molecular Weight; Phenylalanine; Protein Precursors; Protein Processing, Post-Translational; Protein Structure, Tertiary; Solubility; Thiophenes | 1997 |
Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer.
Topics: Affinity Labels; Animals; Azirines; Ceramides; Detergents; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Hydroxamic Acids; Kidney; Lipid Bilayers; Liposomes; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Peptidyl-Dipeptidase A; Phenylalanine; Protease Inhibitors; Solubility; Substrate Specificity; Swine; Thiophenes; Trypsin; Zinc | 1997 |
Interferon gamma induces cell cycle arrest and apoptosis in a model of ovarian cancer: enhancement of effect by batimastat.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboplatin; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cystadenocarcinoma, Serous; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Interferon-gamma; Metalloendopeptidases; Mice; Mice, Nude; Ovarian Neoplasms; Phenylalanine; Survival Rate; Thiophenes; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 1997 |
Role of metalloproteases in the release of the IL-1 type II decoy receptor.
Topics: Alternative Splicing; Dexamethasone; Fibroblasts; Humans; Lymphoma, B-Cell; Metalloendopeptidases; Molecular Weight; Monocytes; Neutrophils; Phenylalanine; Protease Inhibitors; Receptors, Interleukin-1; Receptors, Interleukin-1 Type II; Tetradecanoylphorbol Acetate; Thiophenes; Transfection; Tumor Cells, Cultured | 1997 |
The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors.
Topics: Amino Acids, Branched-Chain; Animals; Bone Matrix; Bone Resorption; Cell Movement; Cells, Cultured; Collagen; Cysteine Endopeptidases; Metalloendopeptidases; Osteoclasts; Phenylalanine; Rabbits; Thiophenes | 1998 |
IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (Fc epsilonRII).
Topics: Animals; B-Lymphocytes; Cell Line, Transformed; Humans; Mice; Monocytes; Phenylalanine; Protease Inhibitors; Receptors, IgE; Signal Transduction; Thiophenes | 1997 |
Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Drug Screening Assays, Antitumor; Endopeptidases; Enzyme Inhibitors; Humans; Hydroxamic Acids; Metalloendopeptidases; Microvilli; Neuroblastoma; Peptidyl-Dipeptidase A; Phenylalanine; Swine; Tetrazolium Salts; Thiophenes; Tumor Cells, Cultured; Zinc | 1998 |
Matrix metalloproteinase inhibitors disrupt spicule formation by primary mesenchyme cells in the sea urchin embryo.
Topics: Animals; Cell Differentiation; Cell Fusion; Mesoderm; Metalloendopeptidases; Morphogenesis; Phenylalanine; Protease Inhibitors; Sea Urchins; Thiophenes | 1998 |
Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblasts.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Communication; Collagen; Drug Combinations; Fibroblasts; Gene Transfer Techniques; Humans; Laminin; Metalloendopeptidases; Mice; Mice, Nude; Phenylalanine; Protease Inhibitors; Proteoglycans; Stromal Cells; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 1998 |
Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
Topics: Amino Acid Sequence; Dipeptides; Humans; Hydroxamic Acids; Ligands; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Models, Molecular; Mutation; Phenylalanine; Protease Inhibitors; Protein Conformation; Structure-Activity Relationship; Thiophenes | 1998 |
Metastasis of Theileria annulata macroschizont-infected cells in scid mice is mediated by matrix metalloproteinases.
Topics: Animals; Cattle; Cell Count; Female; Kidney; Leukocytes; Liver; Lung; Mesentery; Metalloendopeptidases; Mice; Mice, SCID; Phenylalanine; Protease Inhibitors; Spleen; Theileria annulata; Theileriasis; Thiophenes; Time Factors; Virulence | 1998 |
Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Female; Humans; Metalloendopeptidases; Mice; Mice, Nude; Ovarian Neoplasms; Phenylalanine; Protease Inhibitors; Survival Analysis; Thiophenes; Transplantation, Heterologous | 1998 |
Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma in Situ; Humans; Male; Metalloendopeptidases; Mice; Mice, SCID; Neoplasm Invasiveness; Phenylalanine; Prostatic Neoplasms; Protease Inhibitors; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Caveat investor.
Topics: Antineoplastic Agents; Biotechnology; Drug Approval; Humans; Investments; Pancreatitis; Phenylalanine; Thiophenes; United Kingdom | 1998 |
British biotech responds to allegations.
Topics: Antineoplastic Agents; Biotechnology; Clinical Trials, Phase III as Topic; Humans; Metalloendopeptidases; Pancreatitis; Phenylalanine; Thiophenes; United Kingdom | 1998 |
Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor.
Topics: Bone Marrow Cells; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Phenylalanine; Protease Inhibitors; Receptors, Interleukin-6; Tetradecanoylphorbol Acetate; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Tumor Cells, Cultured | 1998 |
The metalloproteinase-mediated pathway is essential for generation of soluble HLA class I proteins by activated cells in vitro: proposed mechanism for soluble HLA release in transplant rejection.
Topics: beta 2-Microglobulin; Cell-Free System; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Graft Rejection; Histocompatibility Antigens Class I; HLA Antigens; Humans; Lymphocyte Activation; Lymphocytes; Metalloendopeptidases; Molecular Weight; Phenylalanine; Pokeweed Mitogens; Solubility; Thiophenes; Time Factors | 1998 |
Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.
Topics: Amphiregulin; Animals; Arsenicals; EGF Family of Proteins; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Growth Substances; Intercellular Signaling Peptides and Proteins; Metalloendopeptidases; Mutation; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Pyrrolidines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-4; Receptors, Cell Surface; Thiocarbamates; Thiophenes; Tumor Cells, Cultured; Tyrosine; Vanadates | 1998 |
A zinc chelator inhibiting gelatinases exerts potent in vitro anti-invasive effects.
Topics: 3T3 Cells; Animals; Chelating Agents; Fatty Acids, Unsaturated; Gelatinases; Histamine; Hydroxamic Acids; Imidazoles; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Phenylalanine; Protease Inhibitors; Thiophenes; Tumor Cells, Cultured; Zinc | 1998 |
Soluble factor(s) released from neutrophils activates endothelial cell matrix metalloproteinase-2.
Topics: Aprotinin; Cells, Cultured; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Activation; Gelatinases; Humans; Leucine; Matrix Metalloproteinase 2; Metalloendopeptidases; Neutrophil Activation; Neutrophils; Pepstatins; Phenanthrolines; Phenylalanine; Protease Inhibitors; Proteins; Serine Proteinase Inhibitors; Serpins; Solubility; Thiophenes; Time Factors; Umbilical Veins | 1998 |
Activation of tumor cell matrix metalloproteinase-2 by neutrophil proteinases requires expression of membrane-type 1 matrix metalloproteinase.
Topics: alpha 1-Antitrypsin; Aprotinin; Collagenases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Activation; Enzyme Precursors; Fibrosarcoma; Gelatinases; Humans; Leucine; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Neoplasm Invasiveness; Neutrophils; Pepstatins; Phenylalanine; Protease Inhibitors; Serine Proteinase Inhibitors; Thiophenes; Transfection; Tumor Cells, Cultured | 1998 |
The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultured; Endopeptidases; Endothelium, Vascular; Humans; Hydroxamic Acids; Peptidyl-Dipeptidase A; Phenylalanine; Protease Inhibitors; Protein Processing, Post-Translational; Thiophenes; Umbilical Veins | 1998 |
Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis.
Topics: Adult; Aged; Animals; Blood-Brain Barrier; Capillary Permeability; Cerebrospinal Fluid; Collagenases; Female; Humans; Intracranial Pressure; Leukocyte Count; Male; Matrix Metalloproteinase 9; Meningitis, Meningococcal; Metalloendopeptidases; Middle Aged; Phenylalanine; Rats; Rats, Wistar; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 1998 |
Membrane type 1-matrix metalloproteinase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cells.
Topics: Animals; Cells, Cultured; Collagen; Culture Media; Dogs; Enzyme Induction; Epithelial Cells; Gels; Hepatocyte Growth Factor; Kidney Tubules; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Morphogenesis; Phenylalanine; Protease Inhibitors; RNA, Antisense; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 1998 |
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis.
Topics: Animals; Antineoplastic Agents; Intestinal Neoplasms; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenylalanine; Protease Inhibitors; Rats; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 1998 |
The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.
Topics: Animals; Antineoplastic Agents; Ascites; Female; Gelatinases; Humans; Mammary Neoplasms, Experimental; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Transplantation; Phenylalanine; Protease Inhibitors; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured | 1996 |
In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.
Topics: Apoptosis; B-Lymphocytes; bcl-X Protein; Burkitt Lymphoma; Cells, Cultured; Depression, Chemical; Enzyme Inhibitors; Humans; Hyperplasia; Neoplastic Stem Cells; NF-kappa B; Palatine Tonsil; Phenylalanine; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 1998 |
The constituent tryptophans and bisANS as fluorescent probes of the active site and of a secondary binding site of stromelysin-1 (MMP-3).
Topics: Acrylamides; Anilino Naphthalenesulfonates; Binding Sites; Catalytic Domain; Fluorescence Polarization; Fluorescent Dyes; Hydroxamic Acids; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Models, Chemical; Phenylalanine; Protease Inhibitors; Protein Binding; Pyrazines; Spectrometry, Fluorescence; Sulfonamides; Thiophenes; Tryptophan | 1998 |
Rat amnion type IV collagen composition and metabolism: implications for membrane breakdown.
Topics: Adenoviridae; Amnion; Animals; Apoptosis; Basement Membrane; Collagen; Collagenases; Extraembryonic Membranes; Female; Gelatinases; Labor, Obstetric; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Organ Culture Techniques; Phenylalanine; Pregnancy; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Thiophenes; Transfection | 1999 |
Induction of matrix metalloproteinases and collagenolysis in chick embryonic membranes before hatching.
Topics: Allantois; Amino Acid Sequence; Animals; Chick Embryo; Collagen; Collagenases; Enzyme Induction; Gelatinases; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Metalloendopeptidases; Mice; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Time Factors | 1999 |
Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing.
Topics: Humans; Hydroxamic Acids; Phenylalanine; Protease Inhibitors; Protein Processing, Post-Translational; Receptors, IgE; Structure-Activity Relationship; Thiophenes | 1998 |
Selective inhibition of low affinity IgE receptor (CD23) processing.
Topics: Hydroxamic Acids; Phenylalanine; Protease Inhibitors; Protein Processing, Post-Translational; Receptors, IgE; Structure-Activity Relationship; Thiophenes | 1998 |
Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases.
Topics: Breast Neoplasms; Collagen; Enzyme Inhibitors; Extracellular Matrix; Female; Fibronectins; Humans; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Proteins; Phenylalanine; Pseudopodia; Thiophenes; Tumor Cells, Cultured | 1998 |
The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.
Topics: Collagenases; Crystallography, X-Ray; Drug Design; Humans; Hydroxamic Acids; Indicators and Reagents; Kinetics; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Models, Molecular; Phenylalanine; Protease Inhibitors; Structure-Activity Relationship; Succinates; Thiophenes | 1998 |
The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms.
Topics: Animals; Antibodies, Monoclonal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Male; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Thiophenes | 1999 |
Matrix metalloproteinase (MMP) inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer.
Topics: Adenocarcinoma; Animals; Blotting, Western; Collagenases; Gelatinases; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes; Tumor Cells, Cultured | 1999 |
Batimastat (BB-94) inhibits matrix metalloproteinases of equine laminitis.
Topics: Animals; Culture Media; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Extracellular Matrix; Foot Diseases; Gelatinases; Hoof and Claw; Horse Diseases; Horses; Inflammation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Thiophenes | 1998 |
The effects of chemically modified tetracyclines (CMTs) on human keratinocyte proliferation and migration.
Topics: Cell Division; Cell Movement; Cells, Cultured; Gelatinases; Gingiva; Humans; Keratinocytes; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Tetracyclines; Thiophenes; Tumor Necrosis Factor-alpha | 1998 |
Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.
Topics: Animals; Brain; Cell Aggregation; Cell Division; Collagenases; Enzyme Inhibitors; Fetus; Gelatinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 7; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neurons; Phenylalanine; Rats; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1999 |
Effect of pulse pressure on vascular smooth muscle cell migration: the role of urokinase and matrix metalloproteinase.
Topics: Animals; Aprotinin; Blood Pressure; Cell Communication; Cells, Cultured; Coculture Techniques; Collagenases; Endothelium, Vascular; Enzyme Inhibitors; Hemorheology; Humans; Hydroxamic Acids; Hyperplasia; Matrix Metalloproteinase 13; Metalloendopeptidases; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Phenylalanine; Pulse; RNA, Messenger; Stress, Mechanical; Thiophenes; Tunica Intima; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1999 |
Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells.
Topics: Breast Neoplasms; Endopeptidases; Humans; Hydroxamic Acids; Metalloendopeptidases; Phenylalanine; Phosphorylation; Protease Inhibitors; Receptor, ErbB-2; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Tyrosine; Vanadates | 1999 |
Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9.
Topics: Breast Neoplasms; Cell Membrane; Cell Movement; Collagenases; Culture Media, Conditioned; Humans; Insulin-Like Growth Factor I; Integrins; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phenylalanine; Polymerase Chain Reaction; Protease Inhibitors; Receptors, Vitronectin; RNA, Messenger; Thiophenes; Tumor Cells, Cultured | 1999 |
Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor.
Topics: Animals; Animals, Newborn; Collagenases; Disease Models, Animal; Gelatinases; Injections, Intraperitoneal; Ischemia; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Phenylalanine; Protease Inhibitors; Retina; Retinal Neovascularization; Retinal Vessels; Thiophenes; Urokinase-Type Plasminogen Activator | 1999 |
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice.
Topics: Angiostatins; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Islet Cell; Collagen; Cyclohexanes; Disease Progression; Drug Evaluation, Preclinical; Endostatins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Staging; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Pancreatic Neoplasms; Peptide Fragments; Phenylalanine; Plasminogen; Sesquiterpenes; Thiophenes | 1999 |
Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action.
Topics: Animals; Base Sequence; Bone Resorption; Cysteine Endopeptidases; DNA Primers; Leucine; Lysosomes; Metalloendopeptidases; Osteoblasts; Phenylalanine; Protease Inhibitors; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes | 1999 |
Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Captopril; Carcinoma, Lewis Lung; Cell Division; Collagenases; Culture Media, Conditioned; Female; Gelatin; Gelatinases; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Phenylalanine; Protease Inhibitors; Survival Rate; Thiophenes | 1999 |
Matrix metalloproteinase inhibition suppresses MMP-2 activity and activation of PANC-1 cells in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; Gelatinases; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Neoplasm Invasiveness; Osmolar Concentration; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes; Tumor Cells, Cultured | 1999 |
Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Phenylalanine; Sesquiterpenes; Suramin; Thiophenes; Triazoles | 1999 |
Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth.
Topics: Antibodies; Apoptosis; Cell Division; Cells, Cultured; Ceramides; Collagenases; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gelatinases; HL-60 Cells; Humans; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Phenylalanine; Sphingomyelin Phosphodiesterase; Sphingosine; Thiophenes; Time Factors | 1999 |
The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells.
Topics: Animals; Cell Movement; Cell Survival; Injections, Intraperitoneal; Injections, Intravenous; Liver Neoplasms; Melanoma, Experimental; Mesenteric Veins; Mice; Microscopy, Video; Neovascularization, Pathologic; Phenylalanine; Thiophenes; Tumor Cells, Cultured | 1999 |
Fluorogenic MMP activity assay for plasma including MMPs complexed to alpha 2-macroglobulin.
Topics: alpha-Macroglobulins; Collagen; Collagenases; Fluorescent Dyes; Humans; Kinetics; Matrix Metalloproteinase 13; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Substrate Specificity; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 1999 |
Inhibition of the metalloproteinase domain of mouse TACE.
Topics: ADAM Proteins; ADAM17 Protein; alpha-Macroglobulins; Amino Acid Sequence; Animals; Metalloendopeptidases; Mice; Phenylalanine; Plasmacytoma; Protease Inhibitors; Recombinant Proteins; Substrate Specificity; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
The metalloproteinase inhibitor batimastat (BB-94) causes cell cycle phase perturbations in ovarian cancer cells.
Topics: Antineoplastic Agents; Bromodeoxyuridine; Cell Cycle; Female; Humans; Metalloendopeptidases; Ovarian Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes | 1999 |
Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats.
Topics: Animals; Antineoplastic Agents; Carcinoma; Collagenases; Colonic Neoplasms; Female; Gelatinases; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Proteins; Peritoneal Neoplasms; Phenylalanine; Rats; Thiophenes; Tumor Cells, Cultured | 1999 |
Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling.
Topics: Actins; Antibodies, Monoclonal; Bronchi; Cell Adhesion; Cell Movement; Cell Size; Cells, Cultured; Collagen; Collagenases; Cytochalasin B; Enzyme Activation; Epithelial Cells; Extracellular Matrix; Humans; Intercellular Junctions; Kinetics; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Microscopy, Video; Models, Biological; Phenylalanine; Pseudopodia; Thiophenes; Vinculin; Wound Healing | 1999 |
Matrix metalloproteinase can facilitate the heparanase-induced promotion of phenotype change in vascular smooth muscle cells.
Topics: Actin Cytoskeleton; Animals; Arteriosclerosis; Carotid Arteries; Catheterization; Cell Division; Coculture Techniques; DNA; Glucuronidase; Glycoside Hydrolases; Humans; Macrophages; Metalloendopeptidases; Muscle, Smooth, Vascular; Phenotype; Phenylalanine; Rabbits; Thiophenes; Thymidine | 1999 |
New drugs on the horizon: matrix metalloproteinase inhibitors.
Topics: Antineoplastic Agents; Azepines; Biphenyl Compounds; Humans; Hydroxamic Acids; Metalloendopeptidases; Organic Chemicals; Phenylalanine; Phenylbutyrates; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 1999 |
Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes.
Topics: Apoptosis; Carcinoma, Squamous Cell; Fas Ligand Protein; fas Receptor; Head and Neck Neoplasms; Humans; Immunoblotting; Jurkat Cells; Lymphocytes, Tumor-Infiltrating; Membrane Glycoproteins; Phenylalanine; RNA, Messenger; Thiophenes; Tumor Cells, Cultured | 1999 |
Batimastat. BB 94, collagenase inhibitors-1.
Topics: Animals; Antineoplastic Agents; Ascites; Drugs, Investigational; Humans; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Neoplasms; Phenylalanine; Pleural Effusion, Malignant; Protease Inhibitors; Thiophenes | 1999 |
Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Endopeptidases; Ethanolamine; Fluorescent Antibody Technique, Indirect; Glycosylphosphatidylinositols; Humans; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Microscopy, Confocal; Molecular Sequence Data; Phenylalanine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Protease Inhibitors; Recombinant Fusion Proteins; Sequence Alignment; Thiophenes; Tritium; Type C Phospholipases | 1999 |
Matrix metalloproteinase homologues from Arabidopsis thaliana. Expression and activity.
Topics: Amino Acid Sequence; Arabidopsis; Base Sequence; Databases, Factual; Electrophoresis, Polyacrylamide Gel; Gene Expression; Humans; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Molecular Sequence Data; Myelin Basic Protein; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Thiophenes; Tissue Inhibitor of Metalloproteinases | 1999 |
Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage.
Topics: Animals; Annexin A5; Apoptosis; Cartilage, Articular; Cells, Cultured; Ceramides; Collagenases; Interleukin-1; Kinetics; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Protease Inhibitors; Proteoglycans; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Sphingosine; Thiophenes; Transcription, Genetic | 2000 |
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Animals; Blotting, Northern; Cell Division; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Middle Aged; Neoplastic Stem Cells; Phenylalanine; Pituitary Gland; Pituitary Hormones; Pituitary Neoplasms; Protease Inhibitors; Rats; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 2000 |
Human immunodeficiency virus type-1 Nef protein induces blood-brain barrier disruption in the rat: role of matrix metalloproteinase-9.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Gene Products, nef; HIV-1; Humans; Injections, Intraventricular; Male; Matrix Metalloproteinase 9; Mice; nef Gene Products, Human Immunodeficiency Virus; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Recombinant Proteins; Thiophenes | 2000 |
Enhanced migration of the acute promyelocytic leukemia cell line NB4 under in vitro conditions during short-term all-trans-retinoic acid treatment.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Cell Adhesion; Cell Line; Cell Movement; Cell Separation; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Matrix; Flow Cytometry; Fluorescence; Gelatinases; Humans; Integrins; Laminin; Leukemia, Promyelocytic, Acute; Matrix Metalloproteinase Inhibitors; Phenylalanine; Proteoglycans; Thiophenes; Time Factors; Tretinoin | 2000 |
Impact of the antimetastatic drug Batimastat on tumor growth and PO2 measured by EPR oximetry in a murine mammary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Electron Spin Resonance Spectroscopy; Female; Mammary Neoplasms, Animal; Metalloendopeptidases; Mice; Mice, Inbred C3H; Oximetry; Oxygen; Phenylalanine; Thiophenes | 1999 |
Neutrophil-derived serine proteinases enhance membrane type-1 matrix metalloproteinase-dependent tumor cell invasion.
Topics: alpha 1-Antitrypsin; Cathepsin G; Cathepsins; Culture Media, Conditioned; Fibrosarcoma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Myeloblastin; Neoplasm Invasiveness; Neutrophils; Pancreatic Elastase; Phenylalanine; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiophenes; Tumor Cells, Cultured | 2000 |
Synthetic inhibitor of matrix metalloproteinases (batimastat) reduces prostate cancer growth in an orthotopic rat model.
Topics: Animals; Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Male; Neoplasm Transplantation; Phenylalanine; Prostatic Neoplasms; Rats; Thiophenes; Tumor Cells, Cultured | 2000 |
Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Humans; Liver Neoplasms, Experimental; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Pancreatic Neoplasms; Phenylalanine; Thiophenes; Tumor Cells, Cultured | 2000 |
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake bothrops asper.
Topics: Animals; Bothrops; Carbon-Oxygen Lyases; Crotalid Venoms; Deoxyribonuclease IV (Phage T4-Induced); DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Interactions; Edema; Hemorrhage; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Phenylalanine; Protease Inhibitors; Thiophenes | 2000 |
Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.
Topics: Animals; Cell Division; Cell Line; Cell Movement; Collagen; COS Cells; Dogs; Extracellular Matrix; Fluorescent Antibody Technique; Hepatocyte Growth Factor; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Microscopy, Electron; Phenylalanine; Protease Inhibitors; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Transfection | 2000 |
Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Chromatography, Affinity; Deoxycytidine; Enzyme-Linked Immunosorbent Assay; Gemcitabine; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Pancreatic Neoplasms; Phenylalanine; Thiophenes; Time Factors; Tumor Cells, Cultured | 2000 |
Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: a study in the atherosclerotic Yucatan micropig.
Topics: Angiography; Angioplasty, Balloon; Animals; Arteriosclerosis; Iliac Artery; Immunohistochemistry; Macrophages; Metalloendopeptidases; Phenylalanine; Postoperative Period; Protease Inhibitors; Swine; Swine, Miniature; Thiophenes; Tunica Intima; Ultrasonography, Interventional | 2000 |
In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity.
Topics: Animals; Cell Line; Cell Movement; Cells, Cultured; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Muscles; Phenylalanine; Protease Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes | 2000 |
The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity.
Topics: Adult; Aged; Antibodies, Monoclonal; Breast Neoplasms; Chemotaxis; Collagen; Enzyme Induction; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha3beta1; Integrins; Ligands; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Phenotype; Phenylalanine; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Tumor Cells, Cultured | 2000 |
Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Chemotaxis; Culture Media, Conditioned; Disease Models, Animal; Encephalitis; Endothelium, Vascular; Glutamic Acid; Infarction, Middle Cerebral Artery; Interleukin-1; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Microglia; Monocytes; Neurons; Phenylalanine; Protease Inhibitors; Rats; RNA, Messenger; Thiophenes; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor.
Topics: Animals; Anticoagulants; Aorta; Becaplermin; Cell Line; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Papio; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Protease Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; Thiophenes; Thrombin; Tyrphostins | 2000 |
Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor.
Topics: Adenocarcinoma; Cell Movement; Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 2000 |
A versatile assay for gelatinases using succinylated gelatin.
Topics: Gelatin; Gelatinases; Humans; Hydrolysis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Phenylalanine; Spectrophotometry; Substrate Specificity; Succinates; Succinic Acid; Thiophenes; Tumor Cells, Cultured | 2000 |
Protease inhibitors: Synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of clostridium histolyticum collagenase.
Topics: Alanine; Clostridium; Hydroxamic Acids; Microbial Collagenase; Phenylalanine; Protease Inhibitors; Thiophenes | 2000 |
Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Central Nervous System; Cloning, Molecular; Drosophila melanogaster; Extracellular Matrix; Extracellular Matrix Proteins; Gene Expression Regulation, Developmental; Humans; In Situ Hybridization; Larva; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Molecular Sequence Data; Peptides; Phenylalanine; Physical Chromosome Mapping; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Substrate Specificity; Thiophenes; Tissue Inhibitor of Metalloproteinases | 2000 |
Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice.
Topics: Animals; Antineoplastic Agents; Cytokines; Drug Administration Schedule; Hypersensitivity, Delayed; Interleukins; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Phenylalanine; Protease Inhibitors; Survival Rate; Thiophenes; Tuberculosis, Pulmonary; Zinc | 2000 |
Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells.
Topics: Animals; Antibodies; Cell Division; Cells, Cultured; Enzyme Induction; Epithelial Cells; Female; Hydroxamic Acids; Mammary Glands, Animal; Matrix Metalloproteinase 9; Phenylalanine; Protease Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tumor Necrosis Factor-alpha | 2000 |
Regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by bone resorptive factors in osteoblastic cells.
Topics: Animals; Animals, Newborn; Bone Resorption; Carrier Proteins; Cell Line; Cytokines; Gelatinases; Hormones; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Osteoblasts; Phenylalanine; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Skull; Thiophenes; Tissue Inhibitor of Metalloproteinases | 2000 |
Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation.
Topics: Blood Platelets; Collagen; Enzyme Activation; Gene Expression Regulation; Humans; In Vitro Techniques; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Phenylalanine; Platelet Aggregation; Protease Inhibitors; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-2 | 2000 |
Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Female; Interleukin-12; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Thiophenes | 2000 |
Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Fibrinolytic Agents; Humans; Intracranial Embolism; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rabbits; Stroke; Thiophenes; Thromboembolism; Tissue Plasminogen Activator | 2000 |
Role of matrix metalloproteinases in blood flow-induced arterial enlargement: interaction with NO.
Topics: Animals; Arteriovenous Shunt, Surgical; Carotid Artery, Common; Coloring Agents; Doxycycline; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hemodynamics; Jugular Veins; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phenylalanine; Rabbits; Regional Blood Flow; Thiophenes; Time Factors | 2000 |
Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury.
Topics: Adult; Alternative Splicing; Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Blotting, Northern; Blotting, Southern; Caseins; Catalytic Domain; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Edetic Acid; Escherichia coli; Exons; Gene Library; Glutathione Transferase; Humans; Immunohistochemistry; Introns; Keratinocytes; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Secreted; Models, Genetic; Molecular Sequence Data; Phenylalanine; Phylogeny; Protease Inhibitors; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; Sequence Homology, Amino Acid; Skin; Testis; Thiophenes; Tissue Distribution | 2001 |
Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94.
Topics: Animals; Brain; Brain Ischemia; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Phenylalanine; Protease Inhibitors; Stroke; Thiophenes; Transcription, Genetic | 2000 |
Selective upregulation of endothelin converting enzyme-1a in the human failing heart.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspartic Acid Endopeptidases; Cardiomyopathy, Dilated; Case-Control Studies; Endothelin-Converting Enzymes; Gene Expression Regulation; Heart Failure; Heart Transplantation; Heart Ventricles; Humans; Metalloendopeptidases; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Tetracyclines; Thiophenes; Up-Regulation | 2000 |
A matrix metalloproteinase inhibitor, batimastat, retards the development of osteolytic bone metastases by MDA-MB-231 human breast cancer cells in Balb C nu/nu mice.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Humans; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Phenylalanine; Thiophenes; Tumor Cells, Cultured | 2001 |
A possible role for metalloproteinases in renal cyst development.
Topics: Animals; Disease Models, Animal; Kidney; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Phenylalanine; Polycystic Kidney, Autosomal Dominant; Protease Inhibitors; Rats; Rats, Inbred Strains; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Transforming Growth Factor beta2 | 2001 |
Potentiation of docetaxel antitumor activity by batimastat against mouse forestomach carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Dose-Response Relationship, Drug; Male; Mice; Paclitaxel; Phenylalanine; Stomach Neoplasms; Taxoids; Thiophenes | 2000 |
In vitro evidence for a bacterial pathogenesis of equine laminitis.
Topics: Animals; Bacterial Proteins; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Foot Diseases; Gram-Negative Bacteria; Histocytochemistry; Hoof and Claw; Horse Diseases; Horses; Lameness, Animal; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylalanine; Protease Inhibitors; Streptococcus bovis; Thermolysin; Thiophenes | 2001 |
Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.
Topics: Angiogenesis Inducing Agents; Animals; Antineoplastic Agents; Caspase 1; Female; Humans; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma, T-Cell; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Phenylalanine; Protease Inhibitors; RNA, Messenger; Thiophenes; Up-Regulation | 2001 |
uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration.
Topics: Antibodies, Monoclonal; Bronchi; Cell Movement; Cells, Cultured; Enzyme Activation; Epithelial Cells; Fibrinolysin; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Respiratory Mucosa; Thiophenes; Urokinase-Type Plasminogen Activator | 2001 |
A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line; Cell Membrane; Endopeptidases; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuroblastoma; Neurons; Peptidyl-Dipeptidase A; Phenylalanine; Point Mutation; Protease Inhibitors; Recombinant Fusion Proteins; Thiophenes; Transfection | 2001 |
Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat.
Topics: Animals; Bleomycin; Body Weight; Bronchoalveolar Lavage Fluid; Cell Count; Hydroxyproline; Male; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Mice, Inbred Strains; Phenylalanine; Protease Inhibitors; Pulmonary Fibrosis; Survival Rate; Thiophenes; Tissue Inhibitor of Metalloproteinases | 2001 |
Validation of an orthotopic model of human lung cancer with regional and systemic metastases.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Large Cell; Cisplatin; Disease Models, Animal; Doxorubicin; Humans; Lung Neoplasms; Male; Mitomycin; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Rats; Rats, Nude; Survival Rate; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays | 2001 |
Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices.
Topics: Binding Sites; Blotting, Western; Cells, Cultured; Endothelium, Vascular; Fibrin; Fibroblast Growth Factor 2; Gene Expression; Humans; Metalloendopeptidases; Microcirculation; Neovascularization, Physiologic; Phenylalanine; Protease Inhibitors; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Transfection; Tumor Necrosis Factor-alpha; Urokinase-Type Plasminogen Activator | 2001 |
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.
Topics: alpha-Amylases; Amino Acid Sequence; Animals; Cell Movement; Cell Size; Extracellular Matrix; Genes, Dominant; Humans; Hyaluronan Receptors; Leucine; Ligands; Matrix Metalloproteinase 14; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Molecular Sequence Data; Neoplasm Invasiveness; Pancreatic Neoplasms; Phenylalanine; Plant Proteins; Protein Processing, Post-Translational; Sequence Deletion; Solubility; Sulfones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Trypsin Inhibitors; Tumor Cells, Cultured | 2001 |
Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development.
Topics: Animals; Cell Size; Cells, Cultured; Culture Media, Conditioned; Culture Media, Serum-Free; Epidermal Growth Factor; Epithelial Cells; Extracellular Matrix; Female; Gelatinases; Humans; Hydroxamic Acids; Immunoblotting; Mammary Glands, Animal; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Organoids; Peptides; Phenylalanine; Phenylmercury Compounds; Protease Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Transforming Growth Factor alpha | 2001 |
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Humans; Metalloendopeptidases; Peptide Fragments; Phenylalanine; Phenylmercuric Acetate; Phosphorylation; Protease Inhibitors; Protein Structure, Tertiary; Receptor, ErbB-2; Thiophenes; Trastuzumab; Tumor Cells, Cultured | 2001 |
Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition.
Topics: Angioplasty, Balloon; Animals; Arteriosclerosis; Feedback; Hemorheology; Iliac Artery; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Models, Cardiovascular; Phenylalanine; Protease Inhibitors; Regression Analysis; Stress, Mechanical; Swine, Miniature; Thiophenes; Tunica Intima; Ultrasonography; Vascular Patency | 2001 |
Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis.
Topics: Animals; Chronic Disease; Colitis, Ulcerative; Disease Models, Animal; Hematoxylin; Intestinal Mucosa; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peroxidase; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thiophenes; Trinitrobenzenesulfonic Acid | 2001 |
Regulation of matrix metalloproteinase activity in ischemic tissue by interleukin-10: role in ischemia-induced angiogenesis.
Topics: Angiography; Animals; Blood Flow Velocity; Capillaries; Disease Models, Animal; Endothelial Growth Factors; Enzyme Activation; Femoral Artery; Fibroblast Growth Factor 2; Hindlimb; Interleukin-10; Ischemia; Laser-Doppler Flowmetry; Lymphokines; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Phenylalanine; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells.
Topics: Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Gene Expression; Humans; Matrix Metalloproteinase 16; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Muscle, Smooth, Vascular; Papio; Phenylalanine; Rats; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Transduction, Genetic | 2001 |
Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation.
Topics: Adipocytes; Captopril; Cell Differentiation; Cells, Cultured; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Protease Inhibitors; Thiophenes | 2001 |
Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Inflammation Mediators; Lipopolysaccharides; Lung; Lung Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Phenylalanine; Pyridones; Thiophenes; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2001 |
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Catalytic Domain; Cations, Divalent; Crystallization; Crystallography, X-Ray; Drug Design; Humans; Macrophages; Matrix Metalloproteinase 12; Metalloendopeptidases; Metals; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Protein Conformation; Sequence Alignment; Substrate Specificity; Thiophenes | 2001 |
Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways.
Topics: Animals; Cartilage, Articular; Cattle; Cells, Cultured; Collagen; Collagenases; Enzyme Activation; Enzyme Precursors; Fibrinolytic Agents; Growth Inhibitors; Humans; Interleukin-1; Matrix Metalloproteinase 3; Oncostatin M; Peptides; Phenylalanine; Plasminogen; Protease Inhibitors; Serine Endopeptidases; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 2001 |
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins | 2001 |
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.
Topics: Animals; Apoptosis; Hepatitis, Animal; Humans; Interferon-gamma; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Phenylalanine; Protease Inhibitors; Recombinant Proteins; Thiophenes; Tumor Necrosis Factor-alpha | 2001 |
[An experimental study of matrix metalloproteinase inhibitor BB-94 inhibits the invasion and metastasis of the human salivary adenoid cystic carcinoma in vitro and in vivo].
Topics: Animals; Carcinoma, Adenoid Cystic; Disease Models, Animal; Female; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Phenylalanine; Protease Inhibitors; Salivary Gland Diseases; Thiophenes | 2001 |
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat.
Topics: Animals; Blotting, Northern; Breast Neoplasms; DNA Primers; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Metalloendopeptidases; Mice; Mice, Nude; Phenylalanine; Plasminogen Activators; Polymerase Chain Reaction; Protease Inhibitors; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Stromal Cells; Thiophenes; Xenograft Model Antitumor Assays | 2001 |
Prostate cancer in bone: importance of context for inhibition of matrix metalloproteinases.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Disease Models, Animal; Humans; Male; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Phenylalanine; Prostatic Neoplasms; Thiophenes | 2002 |
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Bone Remodeling; Bone Transplantation; Calcium; Disease Models, Animal; Fetal Tissue Transplantation; Humans; Immunohistochemistry; In Situ Hybridization; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, SCID; Neoplasm Metastasis; Oligonucleotide Probes; Osteoclasts; Phenylalanine; Prostatic Neoplasms; RNA, Messenger; Thiophenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.
Topics: Adenoviridae; Basement Membrane; Carcinoma, Squamous Cell; Collagen; Collagen Type I; Collagenases; DNA, Complementary; Drug Combinations; Fibrosarcoma; Genetic Vectors; Humans; Laminin; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Genetic; Neoplasm Invasiveness; Neoplasm Metastasis; Phenylalanine; Proteoglycans; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Transfection; Tumor Cells, Cultured | 2002 |
Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat.
Topics: Acute Disease; Animals; Basement Membrane; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Movement; Cells, Cultured; Coloring Agents; Evans Blue; Humans; Interleukin-1; Lung Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neutrophils; Pancreatitis; Peroxidase; Phenylalanine; Protease Inhibitors; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Thiophenes; Trypsin; Tumor Necrosis Factor-alpha | 2002 |
Thermolysin activates equine lamellar hoof matrix metalloproteinases.
Topics: Animals; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hoof and Claw; Horses; In Vitro Techniques; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Protease Inhibitors; Thermolysin; Thiophenes | 2002 |
An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assay.
Topics: 2-Methoxyestradiol; Animals; Aorta; Biological Assay; Carotid Arteries; Drug Evaluation, Preclinical; Estradiol; In Vitro Techniques; Matrix Metalloproteinase Inhibitors; Models, Cardiovascular; Neovascularization, Physiologic; Phenylalanine; Protease Inhibitors; Rats; Reproducibility of Results; Suramin; Swine; Thiophenes | 2001 |
MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure.
Topics: Animals; Collagen; Enzyme Inhibitors; Heart Failure; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Transgenic; Myocardium; Phenotype; Phenylalanine; Reference Values; Survival; Thiophenes; Tumor Necrosis Factor-alpha; Ventricular Function, Left | 2002 |
Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid.
Topics: Aclarubicin; Antineoplastic Agents; Cell Differentiation; Cell Movement; HL-60 Cells; Humans; Leukemia; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phenylalanine; Serine Endopeptidases; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tretinoin; Tumor Cells, Cultured | 2002 |
Quantitation of cell migration in a rat carotid artery balloon injury model. Indications for a perivascular origin of the neointimal cells.
Topics: Animals; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Count; Cell Division; Cell Movement; Cyclophosphamide; Disease Models, Animal; Male; Metalloendopeptidases; Muscle, Smooth, Vascular; Phenylalanine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiophenes; Tunica Intima | 2001 |
Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats.
Topics: Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Intracranial Embolism; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Rats; Rats, Inbred SHR; Sodium, Dietary; Survival Rate; Thiophenes; Thrombolytic Therapy; Tissue Plasminogen Activator | 2002 |
Regulation of galectin-9 expression and release in Jurkat T cell line cells.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Blotting, Western; Carcinogens; Chemotactic Factors, Eosinophil; DNA Primers; Enzyme Inhibitors; Flow Cytometry; Galectins; Gene Expression Regulation; Humans; Jurkat Cells; Lectins; Metalloendopeptidases; Naphthalenes; Phenylalanine; Protein Kinase C; Rabbits; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation | 2002 |
Ligand-induced shedding of discoidin domain receptor 1.
Topics: Animals; Antibodies; Blotting, Western; Cell Line; Collagen; Discoidin Domain Receptors; Enzyme Inhibitors; Female; Fibroblasts; Furin; Humans; Ligands; Metalloendopeptidases; Mice; Molecular Weight; Phenylalanine; Phosphorylation; Precipitin Tests; Protein Isoforms; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Subtilisins; Thiophenes | 2002 |
Stromelysin-1 activation correlates with invasiveness in squamous cell carcinoma.
Topics: Biocompatible Materials; Carcinoma, Squamous Cell; Cell Movement; Collagen; Drug Combinations; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes; Laminin; Matrix Metalloproteinase 3; Neoplasm Invasiveness; Phenylalanine; Protease Inhibitors; Proteoglycans; Skin Neoplasms; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured | 2002 |
Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells.
Topics: Animals; Cell Line; Cloning, Molecular; COS Cells; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA; Epidermal Growth Factor; Epithelial Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Models, Biological; Muscle, Smooth; Oxygenases; Phenylalanine; Phosphorylation; Precipitin Tests; Protein Binding; Signal Transduction; Swine; Thiophenes; Transcriptional Activation; U937 Cells | 2002 |
Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade.
Topics: Angioplasty, Balloon; Animals; Arteries; Cell Movement; Constriction, Pathologic; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hydroxamic Acids; Hyperplasia; Male; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Oligopeptides; Phenylalanine; Rats; Receptors, Vitronectin; Thiophenes; Tunica Intima | 2002 |
Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Survival; Dipeptides; Female; Genetic Therapy; Humans; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Osteolysis; Phenylalanine; Protease Inhibitors; Thiophenes; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.
Topics: Animals; Crotalid Venoms; Cytokines; Interleukin-1; Interleukin-6; Matrix Metalloproteinases; Mice; Muscle, Skeletal; Phenylalanine; Phospholipases A; Phospholipases A2; Skin; Thiophenes; Tumor Necrosis Factor-alpha | 2002 |
Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.
Topics: Animals; Calmodulin; Chlorocebus aethiops; COS Cells; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Mitogen-Activated Protein Kinases; Phenylalanine; Protein Kinase C; Quinazolines; ras Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thiophenes; Transcriptional Activation; Tyrphostins | 2002 |
Inhibition of apoptosis in rat mesangial cells by tissue inhibitor of metalloproteinase-1.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Northern; Blotting, Western; Cells, Cultured; Cloning, Molecular; Glomerular Mesangium; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylalanine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 2002 |
Regulation of matrix metalloproteinases and effect of MMP-inhibition in heart transplant related reperfusion injury.
Topics: Animals; Basement Membrane; Heart Transplantation; Male; Matrix Metalloproteinases; Metalloendopeptidases; Myocardial Reperfusion Injury; Peroxidase; Phenylalanine; Rats; Rats, Inbred Strains; Thiophenes; Transplantation, Homologous; Transplantation, Isogeneic; Tumor Necrosis Factor-alpha; Up-Regulation | 2002 |
Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Antineoplastic Agents; Binding Sites; Biotinylation; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Membrane; COS Cells; Cytoplasm; Dipeptides; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flow Cytometry; Humans; Kidney; Membrane Proteins; Metalloendopeptidases; Microscopy, Fluorescence; Molecular Sequence Data; Phenylalanine; Precipitin Tests; Protease Inhibitors; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; Thiophenes; Time Factors; Tissue Distribution | 2002 |
Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antibodies, Monoclonal; Antibody Specificity; Aspartic Acid Endopeptidases; Cell Line; Culture Media, Conditioned; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Fluorobenzenes; Humans; Kidney; Mass Spectrometry; Metalloendopeptidases; Molecular Sequence Data; Neuroblastoma; Pentanoic Acids; Peptide Fragments; Peptides; Phenylalanine; Recombinant Proteins; Thiophenes; Transfection | 2002 |
The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat.
Topics: Anastomosis, Surgical; Animals; Colon; Hydroxyproline; Ileum; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Models, Animal; Phenylalanine; Postoperative Period; Protease Inhibitors; Rats; Rats, Wistar; Thiophenes; Time Factors; Treatment Outcome | 2002 |
Metalloproteases and guidance of retinal axons in the developing visual system.
Topics: Animals; Axons; Dipeptides; Embryo, Nonmammalian; Growth Cones; Immunohistochemistry; In Vitro Techniques; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Retina; Retinal Ganglion Cells; Superior Colliculi; Thiophenes; Visual Pathways; Xenopus | 2002 |
The matrix metalloproteinase inhibitor batimastat inhibits the lung colonisation of orthotopically implanted malignant pancreatic tumor cells in SCID mice.
Topics: Animals; Antineoplastic Agents; Drug Evaluation; Injections, Intraperitoneal; Lung; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Mice; Mice, SCID; Neoplasm Transplantation; Pancreas; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Thiophenes; Tumor Cells, Cultured | 2002 |
Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.
Topics: Adenoviridae; Aprotinin; Cells, Cultured; Collagen; Culture Media; Defective Viruses; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Fibrin; Fibroblast Growth Factor 2; Genetic Vectors; Heart Diseases; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neovascularization, Pathologic; Neovascularization, Physiologic; Phenylalanine; Protease Inhibitors; Thiophenes; Thrombosis; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3; Transduction, Genetic; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Active matrix metalloprotease-9 in and migration pattern of dendritic cells matured in clinical grade culture conditions.
Topics: Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CCL20; Chemokines, CC; Dendritic Cells; Humans; Macrophage Inflammatory Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylalanine; Protease Inhibitors; Receptors, CCR6; Receptors, Chemokine; Thiophenes; Tissue Inhibitor of Metalloproteinases | 2002 |
MMP inhibition and the development of cerebrovascular atherosclerosis: The road ahead.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix; Female; Glycine; Hemodynamics; Humans; Hydroxamic Acids; Infarction, Middle Cerebral Artery; Intracranial Arteriosclerosis; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Phenylalanine; Thiophenes; Treatment Outcome | 2002 |
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.
Topics: Adipocytes; Animals; Blood Vessels; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Diet; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Obese; Mitosis; Obesity; Phenylalanine; Protease Inhibitors; RNA, Messenger; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3 | 2003 |
The G1 domain of aggrecan released from porcine articular cartilage forms stable complexes with hyaluronan/link protein.
Topics: Aggrecans; Animals; Antibody Specificity; Cartilage, Articular; Culture Media, Conditioned; Culture Techniques; Endopeptidases; Extracellular Matrix Proteins; Glycosaminoglycans; Hyaluronic Acid; Immune Sera; Interleukin-1; Lectins, C-Type; Metalloendopeptidases; Peptide Fragments; Phenylalanine; Protease Inhibitors; Proteoglycans; Rabbits; Swine; Thiophenes; Tretinoin | 2003 |
Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Chi-Square Distribution; Disease Models, Animal; Drug Therapy, Combination; Endothelial Growth Factors; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Matrix Metalloproteinases; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Probability; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro.
Topics: Cell Division; Cells, Cultured; Collagen Type I; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Hydroxamic Acids; Indoles; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes | 2003 |
Inhibition of matrix metalloproteinases reduces local and distant organ injury following experimental acute pancreatitis.
Topics: Amylases; Animals; Lung; Lung Diseases; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Metalloendopeptidases; Models, Animal; Pancreas; Pancreatic Diseases; Pancreatitis, Acute Necrotizing; Peroxidase; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Systemic Inflammatory Response Syndrome; Thiophenes | 2003 |
Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats.
Topics: Animals; Chronic Disease; Collagen; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Pulmonary Circulation; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Thiophenes | 2003 |
Downregulation of caspases and Fas ligand expression, and increased lifespan of neutrophils after transmigration across intestinal epithelium.
Topics: Apoptosis; Caspases; Cell Survival; Down-Regulation; Enzyme Activation; Epithelial Cells; fas Receptor; Humans; Intestinal Mucosa; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phenylalanine; Protease Inhibitors; Thiophenes; Tumor Cells, Cultured | 2003 |
Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Caspase Inhibitors; Cell Survival; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Female; Humans; In Situ Nick-End Labeling; Laminin; Matrix Metalloproteinase 11; Metalloendopeptidases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiophenes; Transfection; Tumor Cells, Cultured; Tyrosine | 2003 |
Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Rats; Rats, Wistar; Recombinant Proteins; Reperfusion; Sucrose; Survival Rate; Thiophenes; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Water | 2003 |
Combining antiangiogenic agents with metronomic chemotherapy enhances efficacy against late-stage pancreatic islet carcinomas in mice.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Islet Cell; Chronotherapy; Indoles; Matrix Metalloproteinase Inhibitors; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Thiophenes | 2002 |
Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation.
Topics: Androstadienes; Animals; Cell Line; COS Cells; Enzyme Inhibitors; ErbB Receptors; Heterotrimeric GTP-Binding Proteins; Lysophospholipids; Models, Chemical; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protease Inhibitors; Protein Isoforms; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Staurosporine; Thiophenes; Transcriptional Activation; Tyrphostins; Wortmannin | 2003 |
Potentiation of docetaxel antitumor activity by batimastat against mouse forestomach carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Synergism; Male; Mice; Neoplasm Transplantation; Phenylalanine; Stomach Neoplasms; Taxoids; Thiophenes; Tumor Cells, Cultured | 2001 |
Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Count; Cells, Cultured; Cerebral Cortex; Doxorubicin; Embryo, Mammalian; fas Receptor; Glial Fibrillary Acidic Protein; Immunoglobulin G; Immunohistochemistry; Indoles; L-Lactate Dehydrogenase; Matrix Metalloproteinase 3; Neurons; Phenylalanine; Phosphopyruvate Hydratase; Precipitin Tests; Rats; Rats, Inbred WKY; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Time Factors; Tissue Inhibitor of Metalloproteinase-3 | 2003 |
Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation.
Topics: Animals; Ascites; Cell Movement; Culture Media, Conditioned; Endothelial Growth Factors; Enzyme Activation; Female; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Nude; Ovarian Neoplasms; Peritoneal Cavity; Phenylalanine; Thiophenes; Transplantation, Heterologous; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
[Effect of batimastat on the dynamic changes of matrix metalloproteinases in liver tissue during the development of hepatocellular carcinoma in rats].
Topics: Animals; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Thiophenes | 2003 |
Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages.
Topics: Annexin A5; Apoptosis; Cells, Cultured; Flow Cytometry; HLA-DR Antigens; Humans; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophages; Mycobacterium tuberculosis; Phenylalanine; Propidium; Thiophenes; Tumor Necrosis Factor-alpha | 2003 |
Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom.
Topics: alpha-Macroglobulins; Animals; Blood Coagulation; Bothrops; Bothrops jararaca Venom; Crotalid Venoms; Hemorrhage; Lung Diseases; Metalloendopeptidases; Mice; Microscopy, Electron; Phenylalanine; Platelet Aggregation Inhibitors; Protease Inhibitors; Thiophenes; Tissue Distribution | 2003 |
Ultrastructural localization of spicule matrix proteins in normal and metalloproteinase inhibitor-treated sea urchin primary mesenchyme cells.
Topics: Animals; California; Cytoskeletal Proteins; Fluorescent Antibody Technique; Golgi Apparatus; Larva; Matrix Metalloproteinases; Microscopy, Immunoelectron; Phenylalanine; Sea Urchins; Thiophenes; Transport Vesicles | 2003 |
Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt.
Topics: Antibodies; Blotting, Western; Brain; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Humans; Immunohistochemistry; Integrin alpha2beta1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Neurons; Phenylalanine; Phosphorylation; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Thiophenes | 2004 |
Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.
Topics: Animals; Dipeptides; Disease Models, Animal; Disease Progression; Hippocampus; Immunohistochemistry; Ischemic Attack, Transient; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Phenylalanine; Protease Inhibitors; Thiophenes | 2004 |
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features.
Topics: Amino Acid Sequence; Catalytic Domain; Cell Line; Crystallography, X-Ray; Enzyme Activation; Humans; Matrix Metalloproteinase 16; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 2004 |
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
Topics: ADAM Proteins; ADAM12 Protein; ADAM17 Protein; Amphiregulin; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Betacellulin; Cells, Cultured; Disintegrins; EGF Family of Proteins; Embryo, Mammalian; Endopeptidases; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Fibroblasts; Genotype; Glycoproteins; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Muscle Proteins; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Tetradecanoylphorbol Acetate; Thiophenes; Transforming Growth Factor alpha | 2004 |
Effect of metalloprotease inhibitors on corneal allograft survival.
Topics: Animals; Cells, Cultured; Corneal Transplantation; Dipeptides; Doxycycline; Endothelium, Corneal; Fas Ligand Protein; Female; Flow Cytometry; Graft Survival; Humans; Male; Matrix Metalloproteinase Inhibitors; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Phenylalanine; Protease Inhibitors; Skin Transplantation; Thiophenes; Transplantation, Homologous | 2004 |
Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation.
Topics: Animals; Blood Coagulation; Bothrops; Costa Rica; Crotalid Venoms; Dose-Response Relationship, Drug; Drug Interactions; Factor X; Hemorrhage; Histological Techniques; Lethal Dose 50; Lung; Metalloendopeptidases; Mice; Phenylalanine; Prothrombin; Snake Bites; Thiophenes; Time Factors | 2004 |
Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Dipeptides; Doxycycline; Enzyme Activation; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Microdomains; Membrane Proteins; Neovascularization, Pathologic; Phenylalanine; Protein Binding; Protein Transport; Receptors, LDL; Recombinant Fusion Proteins; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2004 |
Growth factors improve the in vivo migration of human skeletal myoblasts by modulating their endogenous proteolytic activity.
Topics: Amiloride; Cell Membrane; Cell Movement; Cells, Cultured; Fibroblast Growth Factor 2; Humans; Insulin-Like Growth Factor I; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Skeletal; Myoblasts; Peptide Hydrolases; Phenylalanine; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Serine Proteinase Inhibitors; Thiophenes; Tissue Distribution; Transcription Factors; Urokinase-Type Plasminogen Activator | 2004 |
Influence of the matrix metalloproteinase inhibitor batimastat (BB-94) on periodontal bone destruction in Sprague-Dawley rats.
Topics: Alveolar Bone Loss; Alveolar Process; Analysis of Variance; Animals; Disease Progression; Injections, Intraperitoneal; Male; Matrix Metalloproteinase Inhibitors; Phenylalanine; Placebos; Protease Inhibitors; Radiography, Dental, Digital; Random Allocation; Rats; Rats, Sprague-Dawley; Thiophenes | 2004 |
Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Aorta; Breast Neoplasms; Cell Line, Tumor; Disease Progression; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Microscopy, Fluorescence; Models, Chemical; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Phenylalanine; Piperazines; Protease Inhibitors; Pyrimidines; Rats; Thiophenes; Time Factors; Up-Regulation | 2004 |
Chemically modified tetracyclines act through multiple mechanisms directly on osteoclast precursors.
Topics: Apoptosis; Humans; Macrophage Colony-Stimulating Factor; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Monocytes; Osteoclasts; Phenylalanine; Protease Inhibitors; Recombinant Proteins; Tetracyclines; Thiophenes | 2004 |
Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.
Topics: Animals; Cell Line; Chlorocebus aethiops; Endocytosis; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Metalloendopeptidases; Mice; Mitogen-Activated Protein Kinase 3; Paracrine Communication; Phenylalanine; Phosphorylation; Quinazolines; Rats; Receptors, Somatomedin; Tetradecanoylphorbol Acetate; Thiophenes; Tyrosine; Tyrphostins | 2004 |
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.
Topics: Animals; Cell Division; Cells, Cultured; Ceramides; DNA Replication; Enzyme Activation; ErbB Receptors; Fibroblasts; Humans; Lipoproteins, LDL; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylalanine; Piperazines; Protease Inhibitors; Pyrimidines; Rabbits; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; RNA, Small Interfering; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Thiophenes | 2004 |
Opioid control of MAP kinase cascade.
Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection | 2004 |
Drug loading and elution from a phosphorylcholine polymer-coated coronary stent does not affect long-term stability of the coating in vivo.
Topics: Animals; Blood Vessel Prosthesis; Coated Materials, Biocompatible; Coronary Vessels; Drug Implants; Drug Stability; Implants, Experimental; Materials Testing; Phenylalanine; Phosphorylcholine; Stents; Swine; Thiophenes | 2004 |
A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection.
Topics: Animals; Colony Count, Microbial; Cytokines; Drug Administration Schedule; Female; Granuloma; Leukocyte Count; Lung; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Phenylalanine; Thiophenes; Tuberculosis, Pulmonary | 2004 |
Protease inhibitor treatments reveal specific involvement of matrix metalloproteinase-9 in human adipocyte differentiation.
Topics: Adipocytes; Adult; Cell Differentiation; Female; HIV Protease Inhibitors; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Protease Inhibitors; Stem Cells; Thiophenes | 2005 |
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells.
Topics: Anoikis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 8; Caspases; Cell Line; Endothelium, Vascular; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Humans; Metalloproteases; Phenylalanine; Proto-Oncogene Proteins c-bcl-2; Snake Venoms; Thiophenes | 2005 |
Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy.
Topics: Amidines; Amylases; Animals; Biomarkers; Blood Proteins; Chromatography, Liquid; Endopeptidases; Female; Humans; Imidazoles; Male; Mass Spectrometry; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Organic Chemicals; Phenylalanine; Protease Inhibitors; Saliva; Thiophenes; Urokinase-Type Plasminogen Activator | 2004 |
Cleavage of apolipoprotein E by membrane-type matrix metalloproteinase-1 abrogates suppression of cell proliferation.
Topics: Apolipoproteins E; Cell Line; Cell Proliferation; Gene Expression; Humans; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Thiophenes | 2005 |
MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9.
Topics: Animals; Aorta; Cell Culture Techniques; Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Gels; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Phenylalanine; Rats; Rats, Inbred F344; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Vasoconstriction | 2005 |
[Batimastat-eluting stent implantation for the treatment of coronary artery disease: results of the Brazilian pilot study].
Topics: Adult; Brazil; Catheterization; Coronary Artery Disease; Coronary Restenosis; Female; Humans; Male; Middle Aged; Phenylalanine; Pilot Projects; Prospective Studies; Protease Inhibitors; Stents; Thiophenes | 2005 |
Matrix metalloproteinases in endometrial breakdown and repair: functional significance in a mouse model.
Topics: Animals; Doxycycline; Electrophoresis, Polyacrylamide Gel; Endometrium; Epithelial Cells; Female; Gelatin; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Menstruation; Mice; Mice, Inbred C57BL; Models, Animal; Phenylalanine; Progesterone; Protease Inhibitors; Thiophenes | 2005 |
N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Humans; Hydrogen-Ion Concentration; Hydroxyurea; Inhibitory Concentration 50; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Models, Chemical; Models, Molecular; Oxygen; Phenylalanine; Protein Binding; Protein Conformation; Thiophenes; Zinc | 2006 |
Is the excessive inhibition of matrix metalloproteinases (MMPs) by potent synthetic MMP inhibitors (MMPIs) desirable in periodontitis and other inflammatory diseases? That is: 'Leaky' MMPIs vs excessively efficient drugs.
Topics: Animals; Doxycycline; Humans; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Periodontitis; Phenylalanine; Protease Inhibitors; Rats; Thiophenes | 2005 |
Neuregulin isoforms in dorsal root ganglion neurons: effects of the cytoplasmic domain on localization and membrane shedding of Nrg-1 type I.
Topics: Animals; Animals, Newborn; Brefeldin A; Cell Membrane; Cells, Cultured; Cytoplasm; Embryo, Mammalian; Ganglia, Spinal; Humans; Immunoprecipitation; Neuregulin-1; Neurons; Phenylalanine; Protease Inhibitors; Protein Isoforms; Protein Synthesis Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Transcription, Genetic; Transfection | 2006 |
EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Survival Rate; Thiophenes | 2006 |
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin | 2006 |
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Brain; CD11b Antigen; Electrophoresis; Gene Expression; Malaria, Cerebral; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylalanine; Plasmodium berghei; Thiophenes; Tissue Inhibitor of Metalloproteinases | 2006 |
Effects of an inhibitor of alpha-secretase, which metabolizes the amyloid peptide precursor, on memory formation in rats.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Male; Maze Learning; Memory; Phenylalanine; Rats; Rats, Wistar; Thiophenes | 2006 |
Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.
Topics: Animals; Brain; Brain Diseases; Cell Movement; Central Nervous System; Chemokine CCL2; Cytokines; Female; Gene Expression Regulation; Inflammation Mediators; Injections, Intraperitoneal; Male; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pertussis Toxin; Phenylalanine; Thiophenes; Weight Loss | 2006 |
Neutrophil activator of matrix metalloproteinase-2 (NAM).
Topics: Adult; Amides; Calcimycin; Cathepsin G; Cathepsins; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Enzyme Precursors; Humans; Inflammation; Ionomycin; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Neoplasm Metastasis; Neutrophils; Oligopeptides; Pancreatic Elastase; Phenylalanine; Protease Inhibitors; Proteins; RNA, Messenger; Serine Endopeptidases; Substrate Specificity; Tetradecanoylphorbol Acetate; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Umbilical Veins | 2006 |
Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex.
Topics: Amino Acid Sequence; Catalytic Domain; Crystallography, X-Ray; Metalloproteases; Models, Molecular; Molecular Sequence Data; Oligopeptides; Phenylalanine; Protein Binding; Protein Folding; Sequence Homology, Amino Acid; Substrate Specificity; Thiophenes | 2007 |
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents.
Topics: Animals; Benzyl Compounds; Blood-Brain Barrier; Dexamethasone; Dimethyl Sulfoxide; Disease Models, Animal; Drug Combinations; Drug Evaluation, Preclinical; Encephalitis; Endothelial Cells; Enzyme Inhibitors; Genetic Variation; Heterocyclic Compounds, 1-Ring; Inflammation Mediators; Lipopolysaccharides; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Pentoxifylline; Phenylalanine; Rats; Rats, Inbred WKY; Solvents; Species Specificity; Succinates; Sulfones; Thiophenes | 2007 |
Inhibition of estrogen-induced pituitary tumor growth and angiogenesis in Fischer 344 rats by the matrix metalloproteinase inhibitor batimastat.
Topics: Angiogenesis Inhibitors; Animals; Cell Proliferation; Diethylstilbestrol; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Estrogens; Image Processing, Computer-Assisted; Male; Metalloendopeptidases; Neovascularization, Pathologic; Organ Size; Phenylalanine; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactinoma; Proliferating Cell Nuclear Antigen; Protease Inhibitors; Rats; Rats, Inbred F344; Thiophenes | 2007 |
Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells.
Topics: CD27 Ligand; Dose-Response Relationship, Drug; Humans; Hydroxamic Acids; Leukemia, Lymphocytic, Chronic, B-Cell; Metalloproteases; Phenotype; Phenylalanine; Protease Inhibitors; Solubility; T-Lymphocytes; Thiophenes; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 2007 |
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.
Topics: Animals; beta-Galactosidase; Blood Vessels; Cell Proliferation; Collagen; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Humans; Lac Operon; Matrix Metalloproteinase 14; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Myocytes, Smooth Muscle; Neovascularization, Physiologic; Phenylalanine; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Stromal Cells; Thiophenes; Tissue Culture Techniques | 2007 |
Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases.
Topics: Autocrine Communication; Cell Transformation, Viral; Cells, Cultured; Collagenases; Endothelial Cells; Gene Expression Regulation, Enzymologic; Herpesvirus 8, Human; Humans; Neoplasm Invasiveness; Neovascularization, Pathologic; Paracrine Communication; Phenylalanine; Protease Inhibitors; Response Elements; RNA, Messenger; RNA, Neoplasm; Sarcoma, Kaposi; Thiophenes; Transcription Factor AP-1; Umbilical Veins; Up-Regulation | 2007 |
MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway.
Topics: Animals; Biogenic Amines; Blood Vessels; Butylated Hydroxytoluene; Cell Proliferation; Free Radical Scavengers; Hydrogen Peroxide; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Mutant Strains; Mitogens; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocytes, Smooth Muscle; Oxidation-Reduction; Pargyline; Phenylalanine; Rabbits; Reactive Oxygen Species; RNA, Small Interfering; Serotonin; Signal Transduction; Sphingolipids; Thiazoles; Thiophenes; Tyramine | 2007 |
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice.
Topics: Animals; Antiviral Agents; Disease Models, Animal; Interferon-gamma; Matrix Metalloproteinase 12; Matrix Metalloproteinase 7; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tumor Necrosis Factor-alpha | 2007 |
Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse.
Topics: Animals; Apoptosis; Blotting, Western; Cerebral Hemorrhage; Gene Expression; In Situ Nick-End Labeling; Male; Matrix Metalloproteinases; Mice; Mice, Knockout; Phenylalanine; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-3 | 2008 |
Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions.
Topics: Cell Adhesion; Cell Line, Tumor; Collagen; HeLa Cells; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; Phenylalanine; Plasmids; Thiophenes; Tissue Inhibitor of Metalloproteinase-1 | 2007 |
Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines.
Topics: Animals; Bone Marrow; Cell Movement; Chemokine CXCL2; Chemokines, CXC; Cytochalasin D; Endothelium; Lymphocyte Activation; Male; Matrix Metalloproteinase Inhibitors; Neutrophils; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Phenylalanine; Rats; Rats, Sprague-Dawley; Thiophenes | 2008 |
CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.
Topics: Amino Acids; Aminopeptidases; Animals; Biomarkers, Tumor; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Glycine; HL-60 Cells; Humans; Hydroxamic Acids; Immunoblotting; Leucine; Mice; Oligonucleotide Array Sequence Analysis; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.
Topics: Animals; Cells, Cultured; Flow Cytometry; Heparin-binding EGF-like Growth Factor; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Proteins; Metalloproteases; Mice; Nerve Tissue Proteins; Neuregulin-1; Phenylalanine; Protein Kinase C; Thiophenes; Transforming Growth Factor alpha | 2008 |
Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells.
Topics: Actins; Cell Culture Techniques; Cells, Cultured; Collagen; Dental Stress Analysis; Doxycycline; Electrophoresis, Polyacrylamide Gel; Extracellular Matrix; Fibroblasts; Gels; Humans; Hydroxamic Acids; Indoles; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Periodontal Ligament; Phenylalanine; Protease Inhibitors; Tetracyclines; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tooth Movement Techniques | 2009 |
MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.
Topics: Cells, Cultured; Coculture Techniques; Collagen Type I; Culture Media, Conditioned; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Immunoglobulin E; Mast Cells; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Protease Inhibitors; Thiophenes; Transforming Growth Factor beta | 2009 |
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.
Topics: ADAM Proteins; ADAM17 Protein; Cell Line; Cell Line, Tumor; Dipeptides; Histocompatibility Antigens Class I; Humans; Hydrolysis; Membrane Microdomains; Phenylalanine; Solubility; Thiophenes | 2009 |
TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuroprotective Agents; Phenylalanine; Receptors, Tumor Necrosis Factor, Type I; Reperfusion Injury; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Tumor Necrosis Factor-alpha | 2009 |
Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis.
Topics: Animals; Bacterial Translocation; Ileal Diseases; Ileum; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Naphthol AS D Esterase; Neutrophil Infiltration; Neutrophils; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Phenylalanine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Taurocholic Acid; Thiophenes | 2009 |
Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity.
Topics: Animals; Cell Movement; Cytoplasm; Macrophages; Matrix Metalloproteinase 14; Matrix Metalloproteinase Inhibitors; Mice; Mice, Knockout; Phenylalanine; Thiophenes | 2009 |
Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.
Topics: Animals; Caspase 3; Cell Death; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Ischemic Attack, Transient; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Phenylalanine; Thiophenes; Time Factors | 2010 |
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis.
Topics: Animals; Antigens, CD; Apolipoproteins E; Apoptosis; Atherosclerosis; Cadherins; Caspase 3; Cells, Cultured; Disease Models, Animal; Fas Ligand Protein; Humans; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylalanine; Protease Inhibitors; Recombinant Proteins; Rupture; Thiophenes; Time Factors | 2010 |
[Protective role of MMP-9 inhibitor batimastat in acute lung injury after cardiopulmonary bypass].
Topics: Acute Lung Injury; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Dogs; Lung; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Postoperative Complications; Thiophenes | 2010 |
Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice.
Topics: Animals; Disease Models, Animal; Dystrophin; Fibrosis; Gene Expression Regulation; Humans; Inflammation; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Phenylalanine; Protease Inhibitors; Thiophenes; Transcription Factor AP-1 | 2010 |
GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.
Topics: B7 Antigens; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Membrane; Collagen; Enzyme Activation; Female; Gene Library; Humans; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Phenylalanine; Placenta; Pregnancy; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Thiophenes; Transfection | 2010 |
Matrix metalloproteinase 2 and 9 dysfunction underlie vascular stiffness in circadian clock mutant mice.
Topics: Animals; ARNTL Transcription Factors; Blood Pressure; Carotid Arteries; Carotid Artery Diseases; Cells, Cultured; Circadian Clocks; Elasticity; Endothelial Cells; Extracellular Matrix; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Myocytes, Smooth Muscle; Period Circadian Proteins; Phenylalanine; Protease Inhibitors; Thiophenes; Time Factors; Ultrasonography, Doppler, Pulsed | 2010 |
Proteomics of wound exudate in snake venom-induced pathology: search for biomarkers to assess tissue damage and therapeutic success.
Topics: Animals; Anticoagulants; Biomarkers; Bothrops; Exudates and Transudates; Female; Male; Mass Spectrometry; Metalloendopeptidases; Mice; Muscle, Skeletal; Necrosis; Phenylalanine; Polysaccharides; Protease Inhibitors; Proteome; Proteomics; Snake Bites; Snake Venoms; Thiophenes | 2011 |
Mammalian EGF receptor activation by the rhomboid protease RHBDL2.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Lentivirus; Mice; Microscopy, Fluorescence; Phenylalanine; Serine Endopeptidases; Serine Proteases; Signal Transduction; Substrate Specificity; Thiophenes; Transduction, Genetic | 2011 |
Log-scale dose response of inhibitors on a chip.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Inhibitory Concentration 50; Kinetics; Lab-On-A-Chip Devices; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Microchip Analytical Procedures; Neoplasms; Phenylalanine; Sensitivity and Specificity; Spectrometry, Fluorescence; Thiophenes | 2011 |
LPS activates ADAM9 dependent shedding of ACE from endothelial cells.
Topics: ADAM Proteins; Catalytic Domain; Cell Membrane; Disintegrins; DNA, Complementary; Endothelial Cells; HEK293 Cells; Humans; Lipopolysaccharides; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Metalloproteases; NF-kappa B; Peptidyl-Dipeptidase A; Phenylalanine; Phorbol Esters; Protease Inhibitors; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Thiophenes; Tumor Necrosis Factor-alpha | 2012 |
PTX3 controls activation of matrix metalloproteinase 1 and apoptosis in conjunctivochalasis fibroblasts.
Topics: Acute-Phase Proteins; Aged; Aged, 80 and over; Apoptosis; Aprotinin; Blotting, Western; C-Reactive Protein; Cells, Cultured; Conjunctival Diseases; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fluorescent Antibody Technique, Indirect; Humans; Hydroxamic Acids; In Situ Nick-End Labeling; Matrix Metalloproteinase 1; Middle Aged; Phenylalanine; Real-Time Polymerase Chain Reaction; Serum Amyloid P-Component; Sulfonamides; Tenon Capsule; Thiophenes; Transfection | 2012 |
Effects of MMP inhibitors incorporated within dental adhesives.
Topics: Adolescent; Adult; Dental Bonding; Dental Leakage; Dental Stress Analysis; Dentin; Dentin-Bonding Agents; Dipeptides; Humans; Logistic Models; Materials Testing; Matrix Metalloproteinase Inhibitors; Methacrylates; Molar; Phenylalanine; Polymethacrylic Acids; Resin Cements; Tensile Strength; Thiophenes; Young Adult | 2012 |
Structure of human ADAM-8 catalytic domain complexed with batimastat.
Topics: ADAM Proteins; Catalytic Domain; Humans; Ligands; Membrane Proteins; Models, Molecular; Phenylalanine; Protease Inhibitors; Protein Binding; Protein Unfolding; Thiophenes | 2012 |
Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase.
Topics: Cells, Cultured; HEK293 Cells; Hepatitis A Virus Cellular Receptor 1; Humans; Matrix Metalloproteinase 14; Membrane Glycoproteins; Phenylalanine; Receptors, Virus; RNA, Small Interfering; Structure-Activity Relationship; Thiophenes | 2012 |
Mesothelin promotes invasion and metastasis in breast cancer cells.
Topics: Animals; Breast Neoplasms; Butadienes; Cell Line, Tumor; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Lymphatic Metastasis; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; MCF-7 Cells; Mesothelin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Nitriles; Phenylalanine; Protease Inhibitors; Thiophenes; Transplantation, Heterologous | 2012 |
Involvement of matrix metalloproteinases-2 and -9 in the formation of a lacuna-like cerebral cavity.
Topics: Analysis of Variance; Animals; CD11b Antigen; Disease Models, Animal; Ectodysplasins; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microglia; Minocycline; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Stroke; Stroke, Lacunar; Thiophenes; Time Factors | 2013 |
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
Topics: Antineoplastic Agents; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; beta-Cyclodextrins; Cholagogues and Choleretics; Cyclic AMP; Deoxycholic Acid; Endocytosis; Endosomes; Enzyme Inhibitors; ErbB Receptors; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 5; HEK293 Cells; Humans; Membrane Microdomains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oleanolic Acid; Phenylalanine; Protein Transport; Quinazolines; Receptors, G-Protein-Coupled; Thiophenes; Tyrphostins | 2013 |
Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Deoxycytidine; Dipeptides; Gemcitabine; Humans; Hydroxamic Acids; Membrane Proteins; Neoplasm Proteins; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Thiophenes | 2013 |
Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice.
Topics: Alanine Transaminase; Animals; Bile Acids and Salts; Bile Ducts; Cholestasis; Inflammation; Ligation; Male; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Osteopontin; Phenylalanine; Thiophenes | 2014 |
GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor.
Topics: Calcium Signaling; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Matrix Metalloproteinase Inhibitors; Oligopeptides; Oncogene Proteins; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Quinazolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, LHRH; Thiophenes; Transcriptional Activation; Tyrphostins | 2014 |
Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe.
Topics: Anti-Arrhythmia Agents; Breast Neoplasms; Cathepsin B; Cation Transport Proteins; Cell Line, Tumor; Cell Surface Extensions; Extracellular Matrix; Female; Guanidines; Humans; Hydrogen-Ion Concentration; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Peptide Hydrolases; Phenylalanine; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones; Thiophenes | 2014 |
MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices.
Topics: Actins; Animals; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen Type I; Corneal Keratocytes; Culture Media, Serum-Free; Dipeptides; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Microscopy, Confocal; Phenylalanine; Platelet-Derived Growth Factor; Rabbits; Thiophenes | 2014 |
Natural killer cell-mediated shedding of ULBP2.
Topics: Apoptosis; Cell Line, Tumor; Cell Membrane; Cytotoxicity, Immunologic; GPI-Linked Proteins; Humans; Intercellular Signaling Peptides and Proteins; Killer Cells, Natural; Ligands; Metalloproteases; NK Cell Lectin-Like Receptor Subfamily K; Phenylalanine; Signal Transduction; Thiophenes | 2014 |
Batimastat nanoparticles associated with transcatheter arterial chemoembolization decrease hepatocellular carcinoma recurrence.
Topics: Carcinoma, Hepatocellular; Catheters; Chemoembolization, Therapeutic; Combined Modality Therapy; Humans; Liver Neoplasms; Nanoparticles; Phenylalanine; Recurrence; Thiophenes | 2014 |
Metalloprotease dependent release of placenta derived fractalkine.
Topics: Adult; Cell Line; Cell Membrane; Chemokine CX3CL1; Female; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Inflammation; Metalloproteases; Microvilli; Phenylalanine; Placenta; Pregnancy; Pregnancy Trimester, First; Thiophenes; Trophoblasts | 2014 |
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases; B7 Antigens; Cell Line, Tumor; Dipeptides; HCT116 Cells; HeLa Cells; Humans; Hydroxamic Acids; Killer Cells, Natural; Lymphocyte Activation; MCF-7 Cells; Melanoma; Membrane Proteins; Natural Cytotoxicity Triggering Receptor 3; Phenylalanine; Protease Inhibitors; RNA Interference; RNA, Messenger; RNA, Small Interfering; Thiophenes; Tumor Escape; Up-Regulation | 2014 |
The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Fulvestrant; Humans; MCF-7 Cells; Phenylalanine; Phosphorylation; Protease Inhibitors; Receptor, ErbB-3; Thiophenes | 2014 |
Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cathepsins; DEAD Box Protein 58; DEAD-box RNA Helicases; Gene Expression Regulation, Viral; Interferon Type I; Leucine; Lung; Matrix Metalloproteinases; Mice; Mice, Inbred Strains; Mice, Knockout; Phenylalanine; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Ribavirin; Thiophenes; Viral Load | 2015 |
Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.
Topics: ADAM Proteins; ADAM10 Protein; Adenosine Triphosphate; Amyloid Precursor Protein Secretases; Animals; B-Lymphocytes; Benzoxazoles; Dipeptides; Fluorescent Dyes; Gene Expression Regulation; Humans; Hydroxamic Acids; Lymphocyte Activation; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Fluorescence; Phenylalanine; Primary Cell Culture; Protease Inhibitors; Purinergic P2X Receptor Antagonists; Quinolinium Compounds; Receptors, IgE; Receptors, Purinergic P2X7; Signal Transduction; Spleen; Thiophenes | 2015 |
Simulated physiological stretch-induced proliferation of human bladder smooth muscle cells is regulated by MMPs.
Topics: Cell Proliferation; Cells, Cultured; Collagenases; Gene Expression Regulation, Enzymologic; Humans; Myocytes, Smooth Muscle; Phenylalanine; Protease Inhibitors; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Up-Regulation; Urinary Bladder | 2014 |
Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Cerebellum; Cerebral Hemorrhage; Chemokines; Cytokines; Dentate Gyrus; Disease Models, Animal; Female; Kaplan-Meier Estimate; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Meningitis, Meningococcal; Mice; Phenylalanine; Thiophenes | 2014 |
An MMP-inhibitor modified adhesive primer enhances bond durability to carious dentin.
Topics: Dental Caries; Dentin; Drug Delivery Systems; Humans; In Vitro Techniques; Phenylalanine; Resin Cements; Spectrum Analysis, Raman; Thiophenes; Wettability | 2015 |
Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Chemistry, Pharmaceutical; Disease Models, Animal; Disease Progression; Drug Carriers; Elastin; Immunoconjugates; Macrophages; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Nanoparticles; Phenylalanine; Polyesters; Proteolysis; Rats, Sprague-Dawley; RAW 264.7 Cells; Thiophenes; Time Factors; Vascular Calcification | 2015 |
Protective effects of batimastat against hemorrhagic injuries in delayed jellyfish envenomation syndrome models.
Topics: Angiography; Animals; Bites and Stings; Cnidarian Venoms; Hemorrhage; In Situ Nick-End Labeling; Kidney; Liver; Male; Metalloproteases; Mice; Necrosis; Phenylalanine; Protective Agents; Rats; Rats, Sprague-Dawley; Scyphozoa; Syndrome; Thiophenes; X-Ray Microtomography | 2015 |
Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells.
Topics: ADAM Proteins; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Membrane Glycoproteins; Microscopy, Fluorescence; Phenylalanine; Protease Inhibitors; RNA, Small Interfering; Thiophenes; Transfection | 2016 |
Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon β1-integrin function.
Topics: Animals; Animals, Newborn; Benzodioxoles; Dipeptides; Disks Large Homolog 4 Protein; Estrogen Receptor Modulators; Estrogens; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation; Guanylate Kinases; Hippocampus; Integrin beta1; Integrins; Male; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mice, Knockout; Neurons; Phenylalanine; Piperidines; Pyrazoles; Pyrimidines; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes | 2016 |
Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice.
Topics: Amino Acid Sequence; Animals; Antivenins; Chromatography, High Pressure Liquid; Elapid Venoms; Mice; Necrosis; Neutrophils; Phenylalanine; Skin; Thiophenes | 2016 |
Computational Approaches to Matrix Metalloprotease Drug Design.
Topics: Catalytic Domain; Computational Biology; Drug Design; Humans; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Phenylalanine; Thiophenes | 2017 |
IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.
Topics: ADAM Proteins; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chemotaxis, Leukocyte; Eosinophils; Fluorescent Antibody Technique; Humans; Interleukin-5; Membrane Proteins; Metalloproteases; Phenylalanine; Thiophenes | 2017 |
Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw-scaled) snake venom.
Topics: Animals; Cameroon; Dose-Response Relationship, Drug; Ghana; Hemorrhage; Hydroxamic Acids; Lung; Metalloproteases; Mice; Peptidomimetics; Phenylalanine; Snake Bites; Thiophenes; Viper Venoms; Viperidae | 2017 |
HIV-1 targets L-selectin for adhesion and induces its shedding for viral release.
Topics: ADAM17 Protein; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Dipeptides; HEK293 Cells; HeLa Cells; HIV Core Protein p24; HIV Envelope Protein gp120; HIV-1; Host-Pathogen Interactions; Humans; Hydroxamic Acids; Immunologic Memory; L-Selectin; Lymphocyte Activation; Phenylalanine; Primary Cell Culture; Protease Inhibitors; Receptors, Virus; Thiophenes; Virus Attachment; Virus Internalization; Virus Replication; Virus Shedding | 2018 |
The Protease-Dependent Mesenchymal Migration of Tumor-Associated Macrophages as a Target in Cancer Immunotherapy.
Topics: Amides; Animals; Breast Neoplasms; Cell Movement; Female; Humans; Immunotherapy; Macrophages; Matrix Metalloproteinases; Mesoderm; Mice, Inbred C57BL; Mice, Transgenic; Microscopy; Organ Culture Techniques; Otitis; Phenylalanine; Protease Inhibitors; Pyridines; rho-Associated Kinases; Thiophenes | 2018 |
Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B.
Topics: Adipocytes; Adipogenesis; Adipose Tissue; Adolescent; Age of Onset; Animals; Annexin A2; Case-Control Studies; Dysferlin; Elapid Venoms; Female; Fibrosis; Humans; In Vitro Techniques; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Phenylalanine; Protease Inhibitors; Severity of Illness Index; Stem Cells; Thiophenes; Young Adult | 2019 |
Bond stability of conventional adhesive system with MMP inhibitors to superficial and deep dentin.
Topics: Acid Etching, Dental; Adhesives; Adolescent; Adult; Chlorhexidine; Composite Resins; Dental Bonding; Dentin; Dentin-Bonding Agents; Humans; In Vitro Techniques; Linear Models; Materials Testing; Matrix Metalloproteinase Inhibitors; Phenylalanine; Resin Cements; Solubility; Stress, Mechanical; Surface Properties; Tensile Strength; Thiophenes; Tryptophan; Young Adult | 2019 |
Effect of a Peptide Construct on Differentiated Macrophage MMP-2 and MMP-9 Levels of Varicose Patients.
Topics: Cell Differentiation; Computational Biology; Gene Expression; Humans; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Molecular Docking Simulation; Peptides; Phenylalanine; Thiophenes; Varicose Veins | 2019 |
Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake,
Topics: Animals; Antineoplastic Agents; Antivenins; Binding Sites; Blood Platelets; Catalytic Domain; Collagen; Crotalid Venoms; Crotalus; Drug Repositioning; Erythrocytes; Fibrin; Fibrinolysis; Hemolysis; Humans; Hydroxamic Acids; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Molecular Docking Simulation; Phenylalanine; Protein Binding; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Thiophenes | 2020 |
Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models.
Topics: Animals; Atropine; Cricetinae; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Hydroxamic Acids; Lumican; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Morpholinos; Myopia; Phenylalanine; Sclera; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Zebrafish; Zebrafish Proteins | 2021 |