phenylalanine has been researched along with alpha-chymotrypsin in 272 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 200 (73.53) | 18.7374 |
| 1990's | 33 (12.13) | 18.2507 |
| 2000's | 27 (9.93) | 29.6817 |
| 2010's | 12 (4.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bláha, K; Coupek, J; Seifertová, A; Turková, J; Valentová, O | 1 |
| Becker, EL; Kegeles, SW; Tsung, PW | 1 |
| Kennedy, WP; Schultz, RM | 1 |
| Jering, H; Tschesche, H | 1 |
| Elias, JM; Feinstein, G; Janoff, A; Malemud, CJ | 1 |
| Fischli, W; Leukart, O; Schwyzer, R | 1 |
| Igarashi, K; Kogo, A; Matsumoto, E; Watanabe, Y; Yabuki, M | 1 |
| Chen, R; Gorenstein, DG; Kennedy, WP; Lowe, G; Nurse, D; Schultz, RM | 1 |
| Feinstein, G; Levy, H | 1 |
| Kaletha, K | 1 |
| Fischer, J; Jakubke, HD; Koch, S; Lange, L | 1 |
| Fischer, J; Jakubke, HD; Lange, L | 1 |
| Christova, E; Petkov, D; Stoineva, I | 1 |
| Gertler, A; Shechter, Y | 1 |
| Grossweiner, LI | 1 |
| Champe, SP; Choy, WN; Goldberg, AL; Kowit, JD | 1 |
| Luisi, PL; Saltman, R; Vlach, D | 1 |
| Burrows, EP; Jelinski, LW; Perks, HM; Roswell, DF; White, EH | 1 |
| Halwachs, W; Schügerl, K; Wandrey, C | 1 |
| Cohen, SG; Ehret, A; Mor, G | 1 |
| Fink, AL | 1 |
| Larsen, D; Shaw, E | 1 |
| Ermishkin, LN; Kolomytkin, OV | 1 |
| Grimaldi, JJ; Sykes, BD | 1 |
| Escher, E; Schwyzer, R | 2 |
| Day, RA; Jayasimhulu, K | 1 |
| Ernst, R; Löffler, A; Miederer, SE; Stadelmann, O | 1 |
| Klausner, YS; Rigbi, M | 1 |
| Ernst, R; Löffler, A; Miederer, SE; Stadelmann, O; Wobser, E | 1 |
| Adlercreutz, P; Clapés, P; Mattiasson, B | 1 |
| Flaschel, E; Moresoli, C; Renken, A | 1 |
| Kaneda, N; Karmen, A; Okabe, H; Shirahase, Y; Uji, Y; Watazu, Y | 1 |
| Deininger, DD; Katz, A; Kitzen, JM; Mitchell, R; Ocain, TD; Oshiro, G; Russo, A; Russo, R; Senko, NA; Stupienski, R | 1 |
| Ewald, M; Fischbach, W; Kestel, W; Mössner, J; Stange, JH | 1 |
| Leung, KH | 1 |
| Adlercreutz, P; Clapés, P | 1 |
| Stoeva, S | 1 |
| Geiger, R; Kokotos, G; Tzougraki, C | 1 |
| Kula, MR; Schwarz, A; Steinke, D; Wandrey, C | 1 |
| Abeles, RH; Brady, K; Ringe, D; Wei, AZ | 1 |
| Abeles, RH; Brady, K | 1 |
| Haskell, JH; Silver, MS | 2 |
| Jadaud, P; Wainer, IW | 1 |
| Kodama, H; Ogawa, T; Shimohigashi, Y; Stammer, CH; Waki, M; Yoshitomi, H | 1 |
| Habbal, ZM; Nassar, CF; Nasser, MG; Semrani, PN | 1 |
| Bolis, G; Bopp, BA; Fung, AK; Greer, J; Kleinert, HD; Luly, JR; Marcotte, PA; Plattner, JJ; Sham, HL; Stein, HH | 1 |
| Boocock, MR; Campbell, MS; Chaudhuri, S; Coggins, JR; Lambert, JM; Lewendon, A; Mousdale, DM; Smith, DD | 1 |
| Horn, H; Markwardt, F; Stürzebecher, J; Voigt, B; Wagner, G; Walsmann, P | 1 |
| Hjertén, S; Kourteva, I; Sleigh, RW | 1 |
| Louie, DS; Owyang, C; Tatum, D | 1 |
| Louie, DS; May, D; Owyang, C | 1 |
| Inoue, S; Iwane, H; Matsunaga, Y; Nose, T; Sotomura, M | 1 |
| Katzenellenbogen, JA; Kinder, DH | 1 |
| Gilbert, HJ; Tully, M | 1 |
| Jakubke, HD; Schellenberger, V | 1 |
| Bonicel, J; Bousset-Risso, M; Rovery, M | 1 |
| Fisher, DB; Kaufman, S | 1 |
| Thiele, HG | 1 |
| Jobin, F; Morissette, M; Tremblay, F | 1 |
| Kluh, I; Soliman, MH | 1 |
| Fujii, S; Hayakumo, Y; Muramatsu, M | 1 |
| Hirschhäuser, C; Kionke, M | 1 |
| Benoiton, NI; D'Iorio, A; Petitclerc, C; Tong, JH | 1 |
| Ho, PP; Washington, AL | 1 |
| Carrara, MC; Park, WK; Regoli, D | 1 |
| Gazzinelli, G; Mares-Guia, M; Pellegrino, J | 1 |
| Blake, J; Li, CH | 1 |
| Axén, R; Vretblad, P | 1 |
| Fink, AL; Wildi, E | 1 |
| Jany, KD; Pfleiderer, G; Tabatabai, MS | 1 |
| Hess, GP; Ku, E; McConkey, G; McConn, J | 1 |
| Jakubke, HD; Lange, L | 1 |
| Carson, JH; Gerber, AC; Hadorn, B | 1 |
| Alden, RA; Birktoft, JJ; Kraut, J; Powers, JC; Robertus, JD; Wilcox, PE | 1 |
| Blow, DM; Henderson, R; Hess, GP; Wright, CS | 1 |
| Brownstein, AD; Fruton, JS; Sachdev, GP | 1 |
| Abu-Erreish, GM; Peanasky, RJ | 1 |
| Barker, SA; Gray, CJ; Ireson, JC; McLaren, JV; Parker, RC | 1 |
| Antonov, VK | 1 |
| Ito, A; Shimizu, B; Tokawa, K | 1 |
| Schoellmann, G | 1 |
| Hochstrasser, K; Matzner, M; Reichert, R; Schwarz, S; Werle, E | 1 |
| Kolarz, G; Pietschmann, H | 1 |
| Bizzozero, S; Dutler, H; Kaiser, AW | 1 |
| Bush, KJ; Caplow, M; Lucas, EC | 1 |
| Caplow, M; Caswell, M; Zeeberg, B | 1 |
| Fastrez, J; Fersht, AR | 1 |
| Markussen, J; Sundby, F | 1 |
| Ishii, S; Yamasaki, M; Yoshida, N | 1 |
| Stewart, KK | 1 |
| Dopheide, TA | 1 |
| Blow, DM; Fastrez, J; Fersht, AR | 1 |
| Tulinsky, A; Vandlen, RL | 1 |
| Shanbhag, VP | 1 |
| Kanaoka, Y; Nakayama, H | 1 |
| Fersht, AR; Renard, M | 2 |
| Matta, MS; Rohde, MF | 1 |
| Fujimoto, K; Mikami, N; Tatsuta, K; Umezawa, H; Umezawa, S | 1 |
| Hill, RK; Kumagai, H; Mugibayashi, Y; Ogata, K; Sawada, S; Yamada, H | 1 |
| Huttunen, R; Korhonen, LK | 1 |
| Blumberg, WE; Eisinger, J | 1 |
| Berger, A; Bosshard, HR | 1 |
| Davis, LA; Hess, GP | 1 |
| Andary, TJ; Dabich, D | 1 |
| Jones, JB; Lewis, AJ; Sneddon, DW | 1 |
| Antonov, VK; Ginodman, LM; Lyakisheva, AG | 1 |
| Bump, S; Deyl, Z; Rosmus, J | 1 |
| Silver, MS; Stein, TP; Stoddard, M | 1 |
| Abdel-Hady, SN; Gimlin, DM; Leach, FR; Sherard, SK; Wray, GW | 1 |
| Degani, Y; Patchornik, A; Spande, TF; Witkop, B | 1 |
| Kaplan, S | 1 |
| Crumm, S; Saffran, M; Wuu, TC | 1 |
| Dunnill, P; Lilly, MD; Robinson, PJ | 1 |
| Morihara, K; Tsuzuki, H | 1 |
| Calissano, P; Friesen, A; Moore, BW | 1 |
| Mikola, J; Suolinna, EM | 1 |
| Hultin, T; Sjöqvist, A | 1 |
| Lynn, KR | 1 |
| Ishii, S; Yoshida, N | 1 |
| Lawson, WB; Pattabiraman, TN | 1 |
| Gammon, KL; Richards, JH; Smallcombe, SH | 1 |
| Matta, MS; Silver, MS | 1 |
| Segal, DM | 1 |
| Powers, JC; Robillard, GT; Wilcox, PE | 1 |
| Momany, FA; Platzer, KE; Scheraga, HA | 2 |
| Gahmberg, CG; Kääriäinen, L; Renkonen, O; Simons, K | 1 |
| Alberty, H; Gross, HJ | 1 |
| Bradshaw, RA; Neurath, H; Walsh, KA | 1 |
| Cohen, GH; Davies, DR; Powers, JC; Segal, DM; Wilcox, PE | 1 |
| Eilam-Rubin, G; Kulka, RG; Zelikson, R | 1 |
| Ruscica, J; Shaw, E | 1 |
| Bender, ML; Valenzuela, P | 1 |
| Fersht, AR; Requena, Y | 1 |
| Clement, GE; Potter, R | 1 |
| Faller, LD | 1 |
| Engelhardt, DL; Webster, RE; Wilhelm, RC; Zinder, N | 1 |
| Bieth, J; Métais, P; Warter, J | 1 |
| Geratz, JD | 1 |
| Gorini, L; Old, D | 1 |
| Fink, G; Patat, F | 1 |
| Moriya, H; Yamazaki, K | 1 |
| Oja, H; Oja, SS | 1 |
| Matta, MS; Silver, MS; Sone, T; Stoddard, M | 1 |
| Zeffren, E | 1 |
| Pfleiderer, G; Rothe, W; Zwilling, R | 1 |
| Janoff, A; Klassen, A; Troll, W | 1 |
| Cohen, SG; Lo, LW | 1 |
| Benoiton, NL; Purdie, JE | 1 |
| Kleine, R | 1 |
| Brissieux, D; Felix, F | 1 |
| Antonov, VK; Djachenko, ED; Kozlov, LV; Smirnov, PN; Surovtzev, VI | 1 |
| Williams, A | 1 |
| Damoglou, AP; Lindley, H; Stapleton, IW | 1 |
| Lord, RC; Yu, NT | 1 |
| Elkana, Y; Haas, E; Kulka, RG | 1 |
| Chen, RF | 1 |
| Kaplan, H | 1 |
| Brandt, KG; Hess, GP; Himoe, A; Ku, E; McConn, J | 1 |
| Miyatake, A; Wada, H; Watanabe, T | 1 |
| Jobin, F; Sirois, M | 1 |
| Hultin, T; Ostner, U | 1 |
| Cohen, SG; Schultz, RM | 1 |
| Reavill, RE; Zeffren, E | 1 |
| Busch, H; Roth, C; Sautiere, P; Starbuck, WC | 1 |
| Bonner, J; DeLange, RJ; Fambrough, DM; Smith, EL | 1 |
| Sykes, BD | 2 |
| Pfleiderer, G; Sonneborn, HH | 1 |
| Barnard, EA; Möckel, W | 1 |
| Barnard, EA; Hope, WC | 1 |
| Brandt, KG; DeSa, RJ; Hess, GP; Himoe, A | 1 |
| Biserte, G; Boulanger, Y; Dautrevaux, M; Han, K | 2 |
| Blackwood, CE; Erlanger, BF; Mandl, I | 1 |
| Almqvist, S; Pastan, I | 1 |
| Cooper, AG; Edel, F; Erlanger, BF | 1 |
| Hopsu-Havu, VK; Riekkinen, PJ | 1 |
| Nair, KG; Rabinowitz, M; Zak, R | 1 |
| Cole, ER; Koppel, JL; Olwin, JH | 1 |
| Harrington, WF; Himmelfarb, S; Segal, DM | 1 |
| Brandt, KG; Hess, GP; Himoe, A | 2 |
| Ingles, DW; Knowles, JR | 1 |
| Evans, JM; Richards, JH; Spotswood, T | 1 |
| Gassel, WD; Gramse, M; Havemann, K | 1 |
| Hill, CR; Tomalin, G | 2 |
| Hatanaka, Y; Makisumi, S; Sugahara, Y; Tsunematsu, H | 1 |
| Inada, Y; Matsushima, A; Okada, M | 1 |
| Cox, RA; Kotecha, S | 1 |
| Iwaki, M; Kaufman, S; Phillips, RS | 1 |
| Hsieh, DS; Nakhost, Z; Rha, CK; Shih, V | 1 |
| Berezin, IV; Martinek, K; Semenov, AN | 1 |
| Gorenstein, DG; Shah, DO | 1 |
| Däumer, H; Fischer, J; Jakubke, HD; Könnecke, A; Kuhl, P | 1 |
| Martinek, K; Semenov, AN | 1 |
| DeTar, DF | 1 |
| Schnabel, E | 1 |
| Makisumi, S; Tsunematsu, H | 1 |
| Balny, C; Bec, N; Mozhaev, VV | 1 |
| Khurgin, IuI; Maksareva, EIu | 1 |
| Geiger, R; Miska, W; Monsees, T | 1 |
| Finucane, MD; Malthouse, JP; O'Connell, TP | 1 |
| Li, M; Roswell, DF; White, EH | 1 |
| Carrell, RW; Finch, JT; Lomas, DA; Nukiwa, T; Seyama, K | 1 |
| Benbow, U; Butticè, G; Kurkinen, M; Nagase, H | 1 |
| Malthouse, JP; Murphy, EA; O'Connell, TP | 1 |
| Ge, SJ; Zhang, LX | 1 |
| Bryan, PN; Kendrick, BS; Manning, MC; Matsuura, JE; Meyer, JD; Ruth, JA | 1 |
| Beighton, D; de Graaff, J; Homer, KA | 1 |
| Carey, J; Fukayama, JW; Jin, L; Pelczer, I | 1 |
| Gráf, L; Hudáky, P; Kaslik, G; Venekei, I | 1 |
| Hayashi, Y; Iijima, K; Katada, J; Uno, I; Yasuda, E | 1 |
| Makinen, MW | 1 |
| Abell, AD; Oldham, MD | 1 |
| Ooya, T; Yui, N | 1 |
| Fredholt, K; Friis, GJ; Ostergaard, J; Savolainen, J | 1 |
| Naor, R; Rosen, G; Sela, MN | 1 |
| Bon, C; Braud, S; Maroun, R; Parry, MA; Wisner, A | 1 |
| Karmalkar, RN; Sellergren, B; Shea, KJ | 1 |
| Jennings, IG; Kobe, B; Teh, T | 1 |
| Cassidy, C; Cleland, WW; Frey, PA; Lin, J; Neidhart, D; Wei, Y | 1 |
| Compton, DL; Laszlo, JA | 1 |
| Abell, AD; Harvey, AJ | 1 |
| Cooley, J; Remold-O'Donnell, E; Schechter, NM; Shapiro, SD; Takayama, TK | 1 |
| Bain, DL; McManaman, JL | 1 |
| Elliott, SL; Fromstein, JD; Santerre, JP; Woodhous, KA | 1 |
| Koksch, B; Thust, S | 1 |
| Dafforn, TR; Foreman, RC; Lomas, DA; Mahadeva, R; Parfrey, H; Ravenhill, NA; Zhou, A | 1 |
| GUTFREUND, H; HAMMOND, BR | 1 |
| KUK-MEIRI, S; LICHTENSTEIN, N | 2 |
| NATHANS, D | 1 |
| RIGBI, M; SELA, M | 1 |
| PARKS, PC; SAGER, WF | 1 |
| CONSTANTINE, JW; HESS, HJ | 1 |
| HESS, GP; MERCOUROFF, J; MOON, AY | 1 |
| KOSHLAND, DE; WEINER, H | 1 |
| FLEISHER, GA; ISHIMARU, T; RAMACHANDER, G; ZELLER, EA; ZELLER, V | 1 |
| ENGELHARDT, DL; KONIGSBERG, W; NOTANI, GW; ZINDER, ND | 1 |
| Husain, A; Liu, K; Riek, P; Wouters, MA | 1 |
| Chu, CC; Djavakhishvili, N; Katsarava, R; Kviria, T; Machaidze, M; Tsitlanadze, G | 1 |
| Raskin, I; Yakoby, N | 1 |
| Chu, YC; Hu, SQ; Huang, K; Katsoyannis, PG; Nakagawa, SH; Weiss, MA; Whittaker, J; Xu, B | 1 |
| Goto, M; Kamiya, N; Maruyama, T; Miyako, E | 1 |
| Buczek, O; Bulaj, G; Jimenez, EC; Olivera, BM; Yoshikami, D | 1 |
| Jaśkiewicz, A; Rolka, K; Stawikowska, R; Stawikowski, M; Zabłotna, E | 1 |
| Bajaj, SP; Cascio, D; Chand, HS; Kisiel, W; Schmidt, AE | 1 |
| Goto, M; Kamiya, N; Kubota, F; Maruyama, T; Miyako, E | 1 |
| Hong, R; Klaikherd, A; Rotello, VM; Sandanaraj, BS; Simard, JM; Thayumanavan, S; Vutukuri, DR | 1 |
| Knüttel, T; Meyer, H; Scheper, T | 1 |
| Kanayama, N; Kitano, H; Saito, T | 1 |
| Fawcett, MC; Pulman, LB; Self, CH; Thompson, S | 1 |
| Hu, L; Jiang, Y | 1 |
| Jaśkiewicz, A; Legowska, A; Lesner, A; Miecznikowska, H; Rolka, K; Wysocka, M | 1 |
| Liang, X; Ling, L; Long, D; Qiao, W; Zhang, L; Zhang, R | 1 |
| Downey, SL; Florea, BI; Geurink, PP; Kisselev, AF; Liu, N; Overkleeft, HS; Spaans, MP; van den Nieuwendijk, AM; van der Marel, GA | 1 |
| Chu, CC; Pang, X | 1 |
| Cascante, M; Garcés, JL; Madurga, S; Mas, F; Pastor, I; Vilaseca, E | 1 |
| Martin, SL; Moffitt, KL; Walker, B | 1 |
| Bottesini, C; Dossena, A; Sforza, S; Tedeschi, T | 1 |
| Aiello, F; Balzano, F; Botta, B; Calcaterra, A; Menta, S; Mori, M; Uccello-Barretta, G; Vanni, L | 1 |
| Huscroft, M; Kazlauciunas, A; Khuphe, M; Thornton, PD | 1 |
| Bhattacharyya, K; Ghosh, C; Mondal, T | 1 |
| Canales, R; Held, C; Luong, TQ; Sadowski, G; Verevkin, SP; Wangler, A; Winter, R; Zaitsau, DH | 1 |
| Benická, S; Hlaváč, J; Okorochenkova, Y; Porubský, M | 1 |
| Dastidar, P; Sarkar, K | 1 |
| Held, C; Knierbein, M; Luong, TQ; Sadowski, G; Wangler, A; Winter, R | 1 |
2 review(s) available for phenylalanine and alpha-chymotrypsin
| Article | Year |
|---|---|
Photochemical inactivation of enzymes.
Topics: Carboxypeptidases; Chymotrypsin; Cysteine; Cystine; Energy Transfer; Enzymes; Fluorescence; Kinetics; Light; Mathematics; Models, Chemical; Muramidase; Papain; Peptides; Phenylalanine; Photochemistry; Ribonucleases; Trypsin; Tryptophan; Ultraviolet Rays | 1976 |
Selective cleavage and modification of peptides and proteins.
Topics: Alanine; Aspartic Acid; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Glutamates; Glycine; Hydrogen-Ion Concentration; Methionine; Muramidase; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Proteins; Pyrrolidines; Ribonucleases; Serine; Succinates; Threonine; Tryptophan | 1970 |
270 other study(ies) available for phenylalanine and alpha-chymotrypsin
| Article | Year |
|---|---|
Affinity chromatography on hydroxyalkyl methacrylate gels. III. Adsorption of chymotrypsin to poly(hydroxyalkyl methacrylates) with covalently bound benzyloxycarbonyl-glycyl-D-phenylalanine and -D-leucine as function of pH and ionic strength.
Topics: Binding Sites; Chromatography, Affinity; Chymotrypsin; Glycine; Hydrogen-Ion Concentration; Leucine; Methacrylates; Osmolar Concentration; Phenylalanine; Protein Binding | 1976 |
Some differences in intracellular distribution and properties of the chymotrypsin-like esterase activity of human and rabbit neutrophils.
Topics: Animals; Chymotrypsin; Humans; Hydrogen-Ion Concentration; Isoflurophate; Lysosomes; Molecular Weight; Neutrophils; Organophosphorus Compounds; Phenylalanine; Rabbits; Subcellular Fractions | 1977 |
Mechanism of association of a specific aldehyde "transition-state analogue" to the active site of alpha-chymotrypsin.
Topics: Affinity Labels; Aldehydes; Binding Sites; Chymotrypsin; Hydrogen-Ion Concentration; Kinetics; Mathematics; Phenylalanine; Protein Binding | 1979 |
Replacement of lysine by arginine, phenylalanine and tryptophan in the reactive site of the bovine trypsin-kallikrein inhibitor (Kunitz) and change of the inhibitory properties.
Topics: Amino Acids; Aminopeptidases; Animals; Arginine; Binding Sites; Carboxypeptidases; Cattle; Chymotrypsin; Fibrinolysin; Kinetics; Lysine; Phenylalanine; Protein Binding; Protein Conformation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Trypsin; Trypsin Inhibitor, Kunitz Soybean; Trypsin Inhibitors; Tryptophan | 1976 |
Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue.
Topics: alpha 1-Antitrypsin; Animals; Cartilage, Articular; Chymotrypsin; Cytoplasmic Granules; Disease Models, Animal; Enzyme Inhibitors; Glycosaminoglycans; Humans; Immune Sera; Joint Diseases; Kinetics; Leukocytes; Oligopeptides; Pancreatic Elastase; Peptide Hydrolases; Phenylalanine; Proteoglycans; Rabbits; Sulfur Radioisotopes | 1976 |
Hormone-receptor interactions. Carboranylalanine (Car) as a phenylalanine analogue: reactions with chymotrypsin.
Topics: Binding Sites; Boron Compounds; Chymotrypsin; Phenylalanine; Receptors, Cell Surface | 1977 |
Responsibility of 16S RNA for the stimulation of polypeptide synthesis by spermidine.
Topics: Bacillus thuringiensis; Chymotrypsin; Escherichia coli; Magnesium; Molecular Weight; Peptide Biosynthesis; Phenylalanine; Potassium; Ribonucleases; Ribosomal Proteins; RNA, Bacterial; RNA, Ribosomal; Spermidine | 1977 |
Evidence for hemiacetal formation between N-acyl-L-phenylalaninals and alpha-chymotrypsin by cross-saturation nuclear magnetic resonance spectroscopy.
Topics: Acetals; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Magnetic Resonance Spectroscopy; Phenylalanine; Protein Binding; Serine; Structure-Activity Relationship; Substrate Specificity | 1979 |
The digestion of the oxidized B chain of insulin by human neutrophile proteases: elastase and chymotrypsin-like protease.
Topics: Alanine; Animals; Chymotrypsin; Humans; Insulin; Leucine; Neutrophils; Pancreatic Elastase; Peptide Hydrolases; Phenylalanine; Species Specificity; Substrate Specificity; Swine; Valine | 1979 |
[The evaluation of the kinetic constants of enzyme-catalysed reaction with the use of integrated rate equation (author's transl)].
Topics: Ammonia-Lyases; Chymotrypsin; Dipeptides; Histidine; Histidine Ammonia-Lyase; Humans; Hydrolysis; Kinetics; Lysine; Models, Biological; Phenylalanine; Regression Analysis; Substrate Specificity; Trypsin; Tryptophan; Tyrosine | 1979 |
Enzymatic attack on immobilized substrates. 1. The alpha-chymotrypsin-catalyzed hydrolysis of agarose-bound L-phenylalanine 4-nitroanilide.
Topics: Chymotrypsin; Kinetics; Phenylalanine; Polysaccharides; Sepharose; Structure-Activity Relationship | 1978 |
Enzymatic attack on immobilized substrates. 2. Diffusional limitations in the alpha-chymotrypsin-catalyzed hydrolysis of polyacrylamide-bound l-phenylalanine 4-nitroanilide.
Topics: Acrylamides; Chymotrypsin; Kinetics; Mathematics; Phenylalanine | 1978 |
Catalysis and leaving group binding in anilide hydrolysis by chymotrypsin.
Topics: Anilides; Binding Sites; Chymotrypsin; Hydrolysis; Kinetics; Phenylalanine; Protein Conformation; Substrate Specificity | 1978 |
Enhancement of alpha-chymotrypsin-catalyzed hydrolysis of specific p-nitroanilide substrates by 4-phenylbutylamine derivative of hen egg-white lysozyme.
Topics: Anilides; Butylamines; Chymotrypsin; Egg White; Kinetics; Muramidase; Phenylalanine; Structure-Activity Relationship; Substrate Specificity | 1978 |
Role and location of "protease I" from Escherichia coli.
Topics: Bacterial Proteins; Caseins; Cell Membrane; Chymotrypsin; Cytoplasm; Escherichia coli; Nitrogen; Peptide Hydrolases; Phenylalanine; Subcellular Fractions | 1976 |
Co-oligopeptides of aromatic amino acids and glycine with variable distance between the aromatic residues. VII. Enzymatic synthesis of N-protected peptide amides.
Topics: Amides; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Glycine; Oligopeptides; Phenylalanine; Tryptophan; Tyrosine | 1977 |
Preferential inhibition of alpha-chymotrypsin by the D form of an amino acid derivative, N'-isobutyryl-N-benzyl-N-nitrosophenylalaninamide (ia)
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Nitrosamines; Phenylalanine | 1977 |
Application of immobilized chymotrypsin in a multistage fluidized-bed reactor.
Topics: Chymotrypsin; Enzymes, Immobilized; Industry; Kinetics; Methods; Phenylalanine; Stereoisomerism; Structure-Activity Relationship | 1977 |
Stereoselectivity and reactivity of alpha-chymotrypsin modified at methionine-192.
Topics: Alkylation; Binding Sites; Chymotrypsin; Kinetics; Methionine; Phenylalanine; Propionates; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 1976 |
Cryoenzymology of chymotrypsin: the detection of intermediates in the catalysis of a specific anilide substrate.
Topics: Anilides; Animals; Binding Sites; Chymotrypsin; Cold Temperature; Dogs; Kinetics; Nitro Compounds; Phenylalanine; Protein Binding; Protein Conformation; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics | 1976 |
Active-site-directed alkylation of chymotrypsin by reagents utilizing various departing groups.
Topics: Alkylating Agents; Chymotrypsin; In Vitro Techniques; Phenylalanine; Structure-Activity Relationship | 1976 |
[Electric conductivity of lipid membranes in the presence of proteolytic enzymes and their substrates].
Topics: Cholesterol; Chymotrypsin; Electric Conductivity; Membranes, Artificial; Ovalbumin; Peptide Hydrolases; Phenylalanine; Phospholipids; Protein Denaturation | 1976 |
Stopped flow fourier transform nuclear magnetic resonance spectroscopy. An application to the alpha-chymotrypsin-catalyzed hydrolysis of tert-butyl-L-phenylalanine.
Topics: Chymotrypsin; Hydrolysis; Magnetic Resonance Spectroscopy; Phenylalanine | 1975 |
[Photoaffinity labelling of chymotrypsin. Synthesis of photorecognizable ligands].
Topics: Affinity Labels; Chymotrypsin; Ligands; Oligopeptides; Phenylalanine; Photochemistry | 1975 |
Sequence determination of peptides by mass spectrometry: methods for combining "wet" separation techniques with mass spectrometry.
Topics: Amino Acid Sequence; Amino Acids; Chymotrypsin; Mass Spectrometry; Muramidase; Peptide Fragments; Peptides; Phenylalanine | 1975 |
[Determination of chymotrypsin in the stool by succinyl-L-phenylalanin-P-nitraniliden (Suphepa) in the diagnosis of pancreatic diseases (author's transl)].
Topics: Acute Disease; Anilides; Cholecystokinin; Chronic Disease; Chymotrypsin; Diagnosis, Differential; Duodenum; Evaluation Studies as Topic; False Negative Reactions; False Positive Reactions; Feces; Humans; Indicators and Reagents; Intestinal Secretions; Pancreatic Diseases; Phenylalanine; Recurrence; Secretin | 1975 |
Proceedings: Synthesis of alpha-N-tosyl-p-guanidino-L-phenylalanine methyl ester and its interaction with trypsin, thrombin and chymotrypsin.
Topics: Chymotrypsin; Guanidines; Phenylalanine; Thrombin; Trypsin; Trypsin Inhibitors | 1975 |
[Determination of chymotrypsin in feces using SUPHEPA for the diagnosis of pancreatic diseases].
Topics: Anilides; Chymotrypsin; Feces; Humans; Methods; Pancreatic Diseases; Phenylalanine | 1975 |
Enzymatic peptide synthesis in organic media: a comparative study of water-miscible and water-immiscible solvent systems.
Topics: Chromatography, High Pressure Liquid; Chymotrypsin; Enzymes, Immobilized; Kinetics; Leucine; Models, Chemical; Peptides; Phenylalanine; Solvents | 1990 |
Transesterification of phenylalanine by means of chymotrypsin in a continuous fixed bed reactor.
Topics: Butylene Glycols; Chymotrypsin; Enzymes, Immobilized; Esters; Kinetics; Phenylalanine | 1991 |
Specific assay of serum lactate dehydrogenase isoenzyme 1 by proteolysis with alpha-chymotrypsin and protein denaturation.
Topics: Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Guanidine; Guanidines; Humans; Immunoassay; Isoenzymes; L-Lactate Dehydrogenase; Phenylalanine; Protein Denaturation; Reference Values | 1992 |
New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin.
Topics: Angiotensin I; Animals; Blood Pressure; Chymotrypsin; Drug Stability; Female; Heterocyclic Compounds; Humans; Indoles; Macaca mulatta; Male; Molecular Structure; Phenylalanine; Renin; Structure-Activity Relationship; X-Ray Diffraction | 1992 |
Influence of exogenous application of pancreatic extracts on endogenous pancreatic enzyme secretion.
Topics: Adult; Amylases; Cholecystokinin; Chymotrypsin; Duodenum; Feedback; Humans; Lipase; Male; Pancreas; Pancreatic Extracts; Phenylalanine; Trypsin | 1991 |
Human lymphokine-activated killer (LAK) cells: III. Effect of L-phenylalanine methyl ester on LAK cell activation from human peripheral blood mononuclear cells: possible protease involvement of monocytes, natural killer cells and LAK cells.
Topics: Chymotrypsin; Endopeptidases; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lymphocyte Activation; Monocytes; Phenylalanine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin | 1991 |
Catalytic properties of alpha-chymotrypsin in organic media.
Topics: Amino Acids; Catalysis; Chymotrypsin; Enzymes, Immobilized; Kinetics; Peptides; Phenylalanine; Solvents; Substrate Specificity | 1991 |
Modification of a zinc proteinase from Bacillus mesentericus strain 76 by diethylpyrocarbonate.
Topics: Amino Acid Sequence; Bacillus; Binding, Competitive; Chymotrypsin; Diethyl Pyrocarbonate; Histidine; Hydroxylamine; Hydroxylamines; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Phenylalanine | 1991 |
Fluorogenic substrates for chymotrypsin with 2-quinolinone derivatives as leaving groups.
Topics: Amino Acid Sequence; Animals; Cattle; Chromogenic Compounds; Chymotrypsin; Dipeptides; Fluorescence; Fluorometry; Hydrolysis; Kinetics; Molecular Sequence Data; Phenylalanine; Quinolines; Quinolones; Spectrometry, Fluorescence; Substrate Specificity; Swine | 1990 |
Optimization of enzyme-mediated peptide bond formation.
Topics: Carboxypeptidases; Catalysis; Chymotrypsin; Dipeptides; Enzymes; Hydrogen-Ion Concentration; Hydrolysis; Osmolar Concentration; Papain; Phenylalanine; Serine; Temperature | 1990 |
Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors.
Topics: Amino Acid Sequence; Binding Sites; Chymotrypsin; Dipeptides; Hydrogen Bonding; Kinetics; Phenylalanine; Protein Conformation; Stereoisomerism | 1990 |
Inhibition of chymotrypsin by peptidyl trifluoromethyl ketones: determinants of slow-binding kinetics.
Topics: Acetylation; Chymotrypsin; Dipeptides; Ketones; Kinetics; Phenylalanine; Substrate Specificity; Thermodynamics; Water | 1990 |
Chemistry in a microenvironment of low pH, generated with the aid of an immobilized proteinase.
Topics: Alanine; Buffers; Chemical Phenomena; Chemistry; Chymotrypsin; Collodion; Diffusion; Enzymes, Immobilized; Hydrazines; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Phenylalanine; Prodrugs; Solutions; Tyrosine | 1990 |
The stereochemical resolution of the enantiomers of aspartame on an immobilized alpha-chymotrypsin HPLC chiral stationary phase: the effect of mobile-phase composition and enzyme activity.
Topics: Acylation; Aspartame; Binding Sites; Chromatography, High Pressure Liquid; Chymotrypsin; Dipeptides; Enzymes, Immobilized; Phenylalanine; Stereoisomerism | 1990 |
Acid-sensitive latent inhibitors for proteolytic enzymes: synthesis and characterization.
Topics: Aldehydes; Chemical Phenomena; Chemistry; Chymotrypsin; Hydrazones; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lysosomes; Papain; Phenylalanine; Prodrugs; Protease Inhibitors | 1989 |
Enzyme inhibition by dipeptides containing 2,3-methanophenylalanine, a sterically constrained amino acid.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Dipeptides; Enzyme Inhibitors; Hydrolysis; Kinetics; Phenylalanine | 1989 |
Effect of enzymatic digestion on phenylalanine transport across the small intestine.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chymotrypsin; Female; Intestinal Mucosa; Intestine, Small; Kinetics; Male; Neuraminidase; Phenylalanine; Phospholipase D; Phospholipases; Rats; Rats, Inbred Strains; Trypsin | 1986 |
Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.
Topics: Angiotensinogen; Animals; Binding Sites; Blood Pressure; Chemical Phenomena; Chemistry; Chymotrypsin; Dipeptides; Drug Design; Drug Stability; Ethylene Glycols; Haplorhini; Humans; Phenylalanine; Rats; Renin; Structure-Activity Relationship | 1988 |
Functional domains involved in aromatic amino acid biosynthesis.
Topics: Alcohol Oxidoreductases; Chymotrypsin; Escherichia coli; Hydro-Lyases; Kinetics; Lyases; Molecular Weight; Multienzyme Complexes; Neurospora; Neurospora crassa; Phenylalanine; Phosphotransferases (Alcohol Group Acceptor); Transferases; Trypsin; Tryptophan; Tyrosine | 1985 |
[Synthetic inhibitors of serine proteinases. 34. The effect of modification of the amidino function of N-alpha-substituted 4-amidinophenylalanine amides on inhibitory activity].
Topics: Amidines; Chemical Phenomena; Chemistry; Chymotrypsin; Phenylalanine; Serine Proteinase Inhibitors | 1988 |
Assay for enzyme inhibition: detection of natural inhibitors of trypsin and chymotrypsin.
Topics: Agar; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Chromogenic Compounds; Chymotrypsin; Enzymes, Immobilized; Phenylalanine; Trypsin Inhibitors | 1987 |
Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin.
Topics: Adult; Animals; Cattle; Cholecystokinin; Chymotrypsin; Duodenum; Food; Homeostasis; Humans; Lipase; Male; Oleic Acid; Oleic Acids; Pancreas; Phenylalanine; Trypsin | 1986 |
Trypsin suppression of pancreatic enzyme secretion. Differential effect on cholecystokinin release and the enteropancreatic reflex.
Topics: Adult; Atropine; Cholecystokinin; Chymotrypsin; Duodenum; Humans; Male; Pancreas; Phenylalanine; Reflex; Trypsin | 1986 |
Entrapment of phenylalanine ammonia-lyase in silk fibroin for protection from proteolytic attack.
Topics: Ammonia-Lyases; Animals; Chymotrypsin; Cinnamates; Fibroins; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Rats; Trypsin | 1986 |
Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase.
Topics: Acylation; Alanine; Amino Acids; Binding, Competitive; Boranes; Boronic Acids; Chemical Phenomena; Chemistry; Chymotrypsin; Glycine; Hydrolysis; Isoleucine; Pancreatic Elastase; Phenylalanine; Structure-Activity Relationship; Valine | 1985 |
Protection of phenylalanine ammonia-lyase from proteolytic attack.
Topics: Ammonia-Lyases; Basidiomycota; Cell Membrane Permeability; Chymotrypsin; Cinnamates; Duodenum; Intestinal Secretions; Kinetics; Peptide Hydrolases; Phenylalanine; Phenylalanine Ammonia-Lyase; Trypsin; Ustilaginales | 1985 |
A spectrophotometric assay for the characterization of the S' subsite specificity of alpha-chymotrypsin.
Topics: Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Chymotrypsin; Peptides; Phenylalanine; Solubility; Spectrophotometry; Substrate Specificity | 1986 |
Limited proteolysis of porcine pancreatic lipase. Lability of the Phe 335-Ala 336 bond towards chymotrypsin.
Topics: Alanine; Animals; Chromatography, Gel; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Lipase; Pancreas; Peptide Fragments; Phenylalanine; Substrate Specificity; Swine | 1985 |
Tetrahydropterin oxidation without hydroxylation catalyzed by rat liver phenylalanine hydroxylase.
Topics: Animals; Azides; Carbon Isotopes; Catalase; Catalysis; Chymotrypsin; Free Radicals; Hydroxylation; Kinetics; Liver; Lysophosphatidylcholines; NADP; Oxidation-Reduction; Oxygen; Oxygen Consumption; Peroxidases; Phenylalanine; Phenylalanine Hydroxylase; Pteridines; Pyruvates; Rats; Sodium; Stereoisomerism; Tyrosine; Uncoupling Agents | 1973 |
[Studies on the question of the immune globulin synthesis by human lymphocytes stimulated in vitro by phytohemagglutinin. II. Radiochemical studies].
Topics: Aspergillus; Blood Proteins; Carbon Isotopes; Carboxypeptidases; Chromatography, Thin Layer; Chymotrypsin; Culture Techniques; Freezing; gamma-Globulins; Humans; Hydrolases; Lectins; Leucine; Lymphocytes; Phenylalanine; Radiochemistry; Tissue Extracts; Trichloroacetic Acid; Tritium; Tyrosine; Urea | 1968 |
Platelet reactions and immune processes. 3. The inhibition of platelet aggregation by chymotrypsin substrates and inhibitors.
Topics: Amino Acids; Benzoates; Blood Platelets; Chymotrypsin; Cinnamates; Collagen; Cyclohexanes; Epinephrine; Esterases; Histamine Release; Humans; Isoquinolines; Latex; Lysine; Microspheres; Phenols; Phenylacetates; Phenylalanine; Platelet Adhesiveness; Quinolines; Tryptophan; Tyrosine | 1970 |
Isolation of carbonic anhydrase from dog erythrocytes and determination of its N-terminal amino-acid sequence.
Topics: Amino Acid Sequence; Amino Acids; Animals; Benzoates; Carbonic Anhydrases; Carboxypeptidases; Cattle; Chymotrypsin; Disulfides; Dogs; Electrophoresis, Disc; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Erythrocytes; Histidine; Horses; Humans; Nitro Compounds; Phenylalanine; Serine; Species Specificity; Tryptophan; Ultracentrifugation | 1974 |
Synthetic inhibitors of trypsin, plasmin and chymotrypsin.
Topics: Butyrates; Caseins; Chemical Phenomena; Chemistry; Chymotrypsin; Fibrinolysin; Lysine; Phenylalanine; Propionates; Trypsin Inhibitors | 1967 |
Properties of a human seminal plasma inhibitor for trypsin.
Topics: Anilides; Antifibrinolytic Agents; Aprotinin; Arginine; Benzene Derivatives; Blood; Cell Count; Chemical Phenomena; Chemistry; Chymotrypsin; Electrophoresis; Fertility; Fibrinolysin; Fibrinolytic Agents; Fructose; Humans; Male; Phenylalanine; Semen; Spermatozoa; Thrombin; Trypsin Inhibitors | 1971 |
Resolution of ring-substituted phenylalanines by the action of alpha-chymotrypsin on their ethyl esters.
Topics: Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Dihydroxyphenylalanine; Esters; Ethanol; Fenclonine; Fluorine; Hydrolysis; Ion Exchange Resins; Kinetics; Phenylalanine; Stereoisomerism; Tyrosine | 1971 |
Evidence for a cellular ribonucleic acid synthesis inhibitor from poliovirus-infected HeLa cells.
Topics: Animals; Blood; Carbon Isotopes; Cattle; Cell Survival; Chymotrypsin; Culture Media; Depression, Chemical; Dialysis; DNA; DNA, Neoplasm; Guanine Nucleotides; HeLa Cells; Hot Temperature; Humans; Lipids; Metabolism; Neoplasm Proteins; Phenylalanine; Phospholipases; Poliovirus; Ribonucleases; RNA Nucleotidyltransferases; RNA, Neoplasm; Solubility; Thymidine; Time Factors; Tritium; Uridine; Virus Replication | 1971 |
The enzymatic degradation of angiotensin II analogues by proteolytic enzyme in vitro.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Angiotensin II; Biodegradation, Environmental; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Paper; Chymotrypsin; Cyclohexanecarboxylic Acids; Cyclopentanes; Drug Antagonism; Leucyl Aminopeptidase; Peptide Hydrolases; Peptides; Phenylalanine; Structure-Activity Relationship | 1972 |
Reaction of the main proteolytic fraction of Schistosoma mansoni cercarial enzymes with synthetic substrates and inhibitors of proteolytic enzymes.
Topics: Acetates; Animals; Bradykinin; Chymotrypsin; Esters; Guinea Pigs; Hydrolysis; Ileum; Isoflurophate; Microbial Collagenase; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Schistosoma mansoni; Trypsin; Tyrosine | 1972 |
Adrenocorticotropin. 43. The synthesis and steroidogenic activity of (2-N-methylphenylalanine)-adrenocorticotropin-(1-19).
Topics: Adrenocorticotropic Hormone; Animals; Biological Assay; Chymotrypsin; Electrophoresis, Paper; Electrophoresis, Polyacrylamide Gel; Phenylalanine; Sheep; Trypsin | 1972 |
The use of isocyanides for the immobilization of biological molecules.
Topics: Acrylamides; Adenosine Monophosphate; Biotin; Chromatography, Gel; Chymotrypsin; Cyanides; Esters; Humans; Hydrogen-Ion Concentration; Leucine; Methods; Molecular Weight; NAD; Penicillanic Acid; Penicillin G; Phenylalanine; Protein Binding; RNA; Serum Albumin; Temperature; Tyrosine | 1973 |
Conformational change associated with the acylation of alpha-chymotrypsin by N-acetyl-L-phenylalanine methyl ester.
Topics: Acetates; Binding Sites; Chromatography, Affinity; Chymotrypsin; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Freezing; Hydrogen-Ion Concentration; Kinetics; Methanol; Phenylalanine; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics; Tryptophan | 1974 |
Molecular weight determination of the chymotrypsin-like protease of the larvae of the hornet, Vespa orientalis, by affinity labeling of the active center.
Topics: Amino Acids; Animals; Benzyl Compounds; Binding Sites; Carbon Radioisotopes; Chlorine; Chymotrypsin; Indicators and Reagents; Insecta; Isoflurophate; Ketones; Kinetics; Larva; Mesylates; Molecular Weight; Peptide Hydrolases; Phenylalanine; Protein Binding; Spectrophotometry; Sulfur Radioisotopes; Time Factors; Tosyl Compounds | 1974 |
Studies of the activity of chymotrypsin.
Topics: Amides; Chemical Phenomena; Chemistry; Chymotrypsin; Circular Dichroism; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Leucine; Phenylalanine; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tryptophan; Tyrosine | 1970 |
The alpha-chymotrypsin-catalyzed hydrolysis of sepharose-bound L-phenylalanine 4-nitroanilide.
Topics: Anilides; Binding Sites; Buffers; Chymotrypsin; Cyanogen Bromide; Kinetics; Molecular Weight; Nitro Compounds; Phenylalanine; Protein Binding; Sepharose; Solubility; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
p-Nitrophenylalanine, p-azidophenylalanine, m-azidophenylalanine, and o-nitro-p-azido-phenylalanine as photoaffinity labels.
Topics: Alanine; Azides; Binding Sites; Chymotrypsin; Hydrogen-Ion Concentration; Kinetics; Nitro Compounds; Nitrophenols; Phenols; Phenylalanine; Photochemistry; Protein Binding; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tritium | 1974 |
Partial purification and characterization of a chymotrypsin-like enzyme from human neutrophil leucocytes.
Topics: Binding Sites; Chromatography, Gel; Chymotrypsin; Dithioerythritol; Electrophoresis, Polyacrylamide Gel; Histidine; Humans; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Molecular Weight; Neutrophils; Organ Specificity; Oxidation-Reduction; Pancreas; Phenylalanine; Phosphorus Radioisotopes; Protein Binding; Serine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tosyl Compounds; Ultracentrifugation | 1974 |
The aromatic substrate binding site in subtilisin BPN' and its resemblance to chymotrypsin.
Topics: Benzyl Compounds; Binding Sites; Biological Evolution; Chlorine; Chymotrypsin; Endopeptidases; Formates; Ketones; Models, Structural; Peptides; Phenylalanine; Protease Inhibitors; Protein Binding; Subtilisins; X-Ray Diffraction | 1972 |
-Chymotrypsin: what can we learn about catalysis from x-ray diffraction?
Topics: Acetates; Acridines; Acylation; Benzyl Compounds; Binding Sites; Catalysis; Chymotrypsin; Formates; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Isomerism; Methylation; Models, Structural; Nitrophenols; Phenylalanine; Protein Conformation; Spectrophotometry; Structure-Activity Relationship; Tryptophan; Tyrosine; X-Ray Diffraction | 1972 |
Interaction of 9-peptidylaminoacridines with proteins and nucleic acids.
Topics: Acridines; Amines; Animals; Binding Sites; Cattle; Chymotrypsin; DNA; Fluorescence; Kinetics; Muramidase; Oligopeptides; Pepsin A; Pepsinogens; Peptides; Phenylalanine; Polynucleotides; Salmon; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thymus Gland | 1974 |
Pepsin inhibitors from Ascaris lumbricoides. Pepsin-inhibitor complex: stoichiometry of formation, dissociation, and stability of the complex.
Topics: Acetates; Animals; Ascaris; Chromatography, Gel; Chymotrypsin; Diiodotyrosine; Dipeptides; Drug Stability; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Pepsin A; Phenylalanine; Protease Inhibitors; Protein Denaturation; Proteins; Swine; Time Factors; Trypsin Inhibitors | 1974 |
The reaction of an alpha-aza-amino acid derivative with chymotrypsin and its use as a ligand for covalent affinity purification.
Topics: Acrylamides; Aza Compounds; Chromatography, Affinity; Chromatography, Gel; Chymotrypsin; Chymotrypsinogen; Enzyme Activation; Esters; Hydroxylamines; Kinetics; Ligands; Pepsin A; Phenylalanine; Polymers; Trypsin; Trypsin Inhibitors | 1974 |
[Conformational state of alpha-chymotrypsin in solution and in the enzyme active center].
Topics: Chymotrypsin; Hydrolysis; Phenylalanine; Protein Conformation | 1972 |
Peptide aldehydes inhibiting chymotrypsin.
Topics: Acetates; Aldehydes; Benzyl Compounds; Butanones; Chemical Phenomena; Chemistry; Chymotrypsin; Formates; Imidazoles; Kinetics; Leucine; Oxidation-Reduction; Peptides; Phenethylamines; Phenylalanine; Structure-Activity Relationship; Succinimides; Tryptophan; Tyrosine | 1972 |
[Specific fluorescent derivatives of macromolecules. Synthesis and characterization of N-alpha-dansyl-L-phenylalanyl-chymotrypsino (His-57)-methane and N-alpha-dansyl-L-lysyl-trypsino (His-46)-methane].
Topics: Alkylation; Chemical Phenomena; Chemistry; Chymotrypsin; Fluorescence; Lysine; Macromolecular Substances; Methane; Phenylalanine; Structure-Activity Relationship; Trypsin Inhibitors | 1972 |
[The inhibition of proteolytic enzymes in pathological nasal secretion and of leucocyte proteases by the natural protease inhibitor of nasal secretion (author's transl)].
Topics: Animals; Benzoylarginine Nitroanilide; Cattle; Chymotrypsin; Dogs; Humans; Hydrogen-Ion Concentration; Leukocytes; Mucus; Nasal Mucosa; Peptides; Phenylalanine; Protease Inhibitors; Succinates; Trypsin Inhibitors | 1972 |
[Measurement of neutral peptidase activity in leukocyte homogenate with carboxypropionylphenylalanine-p-nitranilide substrate].
Topics: Adolescent; Adult; Aged; Anilides; Chymotrypsin; Clinical Enzyme Tests; Diagnosis, Differential; Hematologic Diseases; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Leukocyte Count; Leukocytes; Methods; Middle Aged; Nitro Compounds; Peptide Hydrolases; Phenylalanine | 1973 |
A numerical method for acquisition and processing of steady-state kinetic data contained in an entire progression curve. Application to the study of -chymotrypsin-catalyzed hydrolysis.
Topics: Acetates; Acylation; Chymotrypsin; Computers; Electronic Data Processing; Esters; Hydrolysis; Kinetics; Mathematics; Methanol; Methods; Phenylalanine | 1973 |
Chymotrypsin catalysis. Evidence for a new intermediate. 3.
Topics: Catalysis; Chymotrypsin; Hydrazines; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Phenylalanine | 1973 |
Concerning a reported change in rate-determining step in chymotrypsin catalysis.
Topics: Catalysis; Chymotrypsin; Hydrazines; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Phenylalanine | 1973 |
Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin.
Topics: Acylation; Alanine; Anilides; Benzoates; Binding, Competitive; Chemical Phenomena; Chemistry; Chymotrypsin; Dimethylformamide; Electrophoresis, Paper; Esters; Glycine; Hydrazines; Hydrolysis; Kinetics; Mathematics; Methyl Ethers; Nitrobenzenes; Osmolar Concentration; Peptides; Phenylalanine; Quaternary Ammonium Compounds; Structure-Activity Relationship; Thermodynamics; Tritium | 1973 |
Isolation and amino-acid sequence of the C-peptide of duck proinsulin.
Topics: Amino Acid Sequence; Animals; Autoanalysis; Biological Evolution; Carboxypeptidases; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Ducks; Histidine; Leucyl Aminopeptidase; Pancreas; Peptides; Phenylalanine; Proinsulin; Tyrosine | 1973 |
Specificity-determining site of alpha-chymotrypsin. 3. Inactivation of alpha-chymotrypsin by p-diazo-N-acetyl-L-phenylalanine methyl ester.
Topics: Amino Acids; Azo Compounds; Benzene Derivatives; Binding Sites; Chymotrypsin; Esters; Phenylalanine; Propionates | 1973 |
A method for automated analyses of the activities of trypsin, chymotrypsin and their inhibitors.
Topics: Anilides; Animals; Arginine; Autoanalysis; Benzoates; Cattle; Chymotrypsin; Glutarates; Methods; Nitro Compounds; Pancreas; Phenylalanine; Plants; Trypsin; Trypsin Inhibitors | 1973 |
The primary structure of a protein, component 0.62, rich in glycine and aromatic residues, obtained from wool keratin.
Topics: Amino Acid Sequence; Animals; Autoanalysis; Chromatography, Paper; Chymotrypsin; Electrophoresis, Paper; Glycine; Keratins; Peptides; Phenylalanine; Sheep; Thermolysin; Trypsin; Tryptophan; Tyrosine; Wool | 1973 |
Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. A stereochemical interpretation.
Topics: Acetates; Acylation; Amides; Amino Acids; Aniline Compounds; Animals; Binding Sites; Carboxylic Acids; Catalysis; Cattle; Chymotrypsin; Furans; Hydrazines; Hydrolysis; Kinetics; Models, Chemical; Pancreas; Peptides; Phenylalanine; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Trypsin Inhibitors; Tryptophan; Tyrosine | 1973 |
Changes in the tertiary structure of alpha-chymotrypsin with change in pH: p4 4.2-6.7.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Chymotrypsin; Histidine; Hydrogen-Ion Concentration; Macromolecular Substances; Methionine; Models, Structural; Phenylalanine; Protein Binding; Protein Conformation; Serine; Tyrosine; Uranium; X-Ray Diffraction | 1973 |
Diffusion of proteins across a liquid-liquid interface.
Topics: Chymotrypsin; Dextrans; Diffusion; Kinetics; Mathematics; Membranes, Artificial; Methemoglobin; Molecular Weight; Myoglobin; Phaeophyceae; Phenylalanine; Pigments, Biological; Polyethylene Glycols; Proteins; Ribonucleases; Spectrophotometry, Ultraviolet; Time Factors; Vitamin B 12 | 1973 |
A photoaffinity labeling of the active site of alpha-chymotrypsin with TPDK.
Topics: Amino Acids; Azo Compounds; Binding Sites; Chymotrypsin; Diazonium Compounds; Kinetics; Light; Phenylalanine; Protein Binding; Radiation Effects; Tosyl Compounds | 1973 |
Anomalous pH dependence of kcat-KM in enzyme reactions. Rate constants for the association of chymotrypsin with substrates.
Topics: Acetates; Binding Sites; Chymotrypsin; Hydrogen-Ion Concentration; Kinetics; Mathematics; Nitrophenols; Oscillometry; Phenylalanine; Protein Binding; Spectrophotometry, Ultraviolet; Tryptophan; Tyrosine | 1973 |
Alpha-chymotrypsin: effects of bicyclic substrate geometry and hydrophobicity on reactivity.
Topics: Binding Sites; Carboxylic Acids; Chymotrypsin; Cinnamates; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnetic Resonance Spectroscopy; Mathematics; Models, Structural; Molecular Conformation; Nitrobenzenes; Phenylalanine; Protein Binding; Protein Conformation; Spectrophotometry; Spiro Compounds | 1973 |
The structure of chymostatin, a chymotrypsin inhibitor.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Hydrolysis; Magnetic Resonance Spectroscopy; Oligopeptides; Optical Rotation; Phenylalanine; Spectrophotometry, Infrared; Valine | 1973 |
Stereochemistry of ammonia elimination from L-tyrosine with L-phenylalanine ammonia-lyase.
Topics: Ammonia-Lyases; Binding Sites; Chymotrypsin; Deuterium; Magnetic Resonance Spectroscopy; Mitosporic Fungi; Optical Rotation; Phenylalanine; Stereoisomerism; Tritium; Tyrosine | 1973 |
New trypsin- and chymotrypsin-binding factor in rat plasma.
Topics: Animals; Blood Proteins; Caseins; Chromatography, Gel; Chymotrypsin; Glycine max; Humans; Macroglobulins; Molecular Weight; Nitro Compounds; Phenylalanine; Protein Binding; Rats; Trypsin; Trypsin Inhibitors | 1973 |
Binding constants from zone transport of interacting molecules.
Topics: Acridines; Animals; Binding Sites; Cattle; Centrifugation; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Paper; Chymotrypsin; Computers; Countercurrent Distribution; Diffusion; Electrophoresis; Electrophoresis, Polyacrylamide Gel; Escherichia; Glutamates; Macromolecular Substances; Mathematics; Models, Chemical; Pancreas; Phenylalanine; Protein Binding; RNA, Bacterial; RNA, Transfer | 1973 |
The topographical differences in the active site region of alpha-chymotrypsin, subtilisin Novo, and subtilisin Carlsberg. Mapping the aromatic binding site by inhibitors (virtual substrates).
Topics: Amino Acid Sequence; Amino Acids; Benzyl Compounds; Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Chymotrypsin; Formates; Hydrogen-Ion Concentration; Isomerism; Kinetics; Mathematics; Models, Chemical; Oligopeptides; Phenylalanine; Structure-Activity Relationship; Subtilisins; Thermodynamics; X-Ray Diffraction | 1974 |
Determination of dissociation constants of crystalline-alpha-chymotrypsin complexes.
Topics: Carbon Radioisotopes; Chymotrypsin; Indoles; Ligands; Phenylalanine; Protein Binding; Protein Conformation; Spectrophotometry; Tosyl Compounds; X-Ray Diffraction | 1974 |
A sensitive polyacrylamide disc gel method for detection of proteinases.
Topics: Animals; Caseins; Chlorine; Chymotrypsin; Diffusion; Electrophoresis, Disc; Embryo, Mammalian; Evaluation Studies as Topic; Female; Hemoglobins; Hydrogen-Ion Concentration; Lysine; Male; Methods; Mice; Microchemistry; Peptide Hydrolases; Phenylalanine; Pregnancy; Protein Denaturation; Semen; Solubility; Spectrophotometry, Ultraviolet; Tosyl Compounds; Trypsin | 1974 |
pH dependence of chymotrypsin catalysis. Appendix: substrate binding to dimeric alpha-chymotrypsin studied by x-ray diffraction and the equilibrium method.
Topics: Acetates; Acridines; Amides; Autoanalysis; Binding Sites; Catalysis; Chymotrypsin; Diamines; Hydrazines; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Macromolecular Substances; Models, Chemical; Nitrobenzenes; Osmolar Concentration; Phenylalanine; Protein Binding; Protein Conformation; Protons; Semicarbazides; Spectrophotometry; Structure-Activity Relationship; Tritium; X-Ray Diffraction | 1974 |
Inhibition of alpha-chymotrypsin by hydroxymethyl analogues of D-and L-N-acetylphenylalanine and N-acetyltryptophan of potential affinity labeling value.
Topics: Acetates; Binding Sites; Binding, Competitive; Chromatography, Paper; Chymotrypsin; Deuterium; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Optical Rotation; Phenylalanine; Protein Binding; Spectrophotometry, Infrared; Structure-Activity Relationship; Tryptophan | 1974 |
Kinetics of the alpha-chymotrypsin-catalyzed hydrolysis of N-ACETYL-L-phenylalanylglycine amide in the equilibrium state: profit of an acylenzyme mechanism.
Topics: Acylation; Amides; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Chymotrypsin; Glycine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Oxygen Isotopes; Phenylalanine | 1974 |
Studies on the structure of collagen. II. The nature of the N- and C-terminals in enzyme-treated and untreated collagen.
Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Cattle; Chymotrypsin; Collagen; Glycine; Hydrazines; Indicators and Reagents; Leucine; Lysine; Naphthalenes; Nitrobenzenes; Pepsin A; Peptide Hydrolases; Phenylalanine; Skin | 1967 |
On the mechanism of the pepsin-catalyzed exchange of carboxylic acids with water-18O.
Topics: Acids; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Deuterium; Hydrogen-Ion Concentration; Kinetics; Oxygen Isotopes; Pepsin A; Phenylalanine; Water | 1970 |
Effect of fluorophenylalanine on bacteriophage MS2 replication.
Topics: Adsorption; Carbon Isotopes; Cell Membrane; Centrifugation, Density Gradient; Cesium; Chlorides; Chromatography, Paper; Chymotrypsin; Coliphages; Depression, Chemical; Escherichia coli; Fluorine; Immune Sera; Phenylalanine; Ribonucleases; RNA, Messenger; RNA, Viral; Tritium; Viral Proteins; Virus Replication | 1970 |
Lysine suppressor in Escherichia coli.
Topics: Amino Acid Sequence; Autoradiography; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chlorides; Chymotrypsin; Coliphages; Escherichia coli; Genetics, Microbial; Lysine; Mutation; Peptides; Phenylalanine; Suppression, Genetic; Viral Proteins | 1971 |
Amino acid sequence of porcine neurophysin-I.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Disulfides; Electrophoresis, Paper; Formates; Hydrochloric Acid; Hydrolysis; Kinetics; Leucine; Oxidation-Reduction; Papain; Pepsin A; Peptides; Phenylalanine; Pituitary Gland, Posterior; Swine; Trypsin | 1971 |
Porous glass as a solid support for immobilisation or affinity chromatography of enzymes.
Topics: Aldehydes; Carboxypeptidases; Chromatography; Chromatography, Affinity; Chymotrypsin; Dipeptides; Drug Stability; Escherichia coli; Galactosidases; Glass; Glutarates; Glycine; Hot Temperature; Methods; Phenylalanine | 1971 |
Comparison of the specificities of various serine proteinases from microorganisms.
Topics: Amino Acids; Aspergillus; Bacillus subtilis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Hydrogen-Ion Concentration; Insulin; Kinetics; Leucine; Peptide Hydrolases; Peptides; Phenylalanine; Protease Inhibitors; Serine; Streptomyces; Tyrosine | 1969 |
Effect of calcium ion on S-100, a protein of the nervous system.
Topics: Acrylates; Animals; Antigens; Brain Chemistry; Calcium; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Electrophoresis; Fluorometry; Immune Sera; Immunodiffusion; Magnesium; Methods; Nerve Tissue Proteins; Optical Rotatory Dispersion; Phenylalanine; Potassium; Protein Binding; Protein Denaturation; Quaternary Ammonium Compounds; Rabbits; Sodium; Solubility; Spectrophotometry; Strontium; Sulfhydryl Compounds; Time Factors; Tryptophan; Tyrosine; Urea; Viscosity | 1969 |
Purification and properties of an inhibitor of microbial alkaline proteinases from barley.
Topics: Amino Acids; Aspergillus; Bacillus subtilis; Caseins; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chymotrypsin; Drug Stability; Edible Grain; Electrophoresis, Disc; Ethanol; Ethyl Ethers; Glutarates; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Mitosporic Fungi; Molecular Weight; Nitro Compounds; Papain; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Quaternary Ammonium Compounds; Spectrophotometry; Streptomyces; Sulfates; Trypsin; Ultraviolet Rays | 1971 |
Analogies in protein pattern and conformation among ribosomes from different classes of vertebrates.
Topics: Amphibians; Animals; Anura; Carbon Isotopes; Chickens; Chymotrypsin; Coloring Agents; Cyprinidae; Detergents; Edetic Acid; Electrophoresis; Electrophoresis, Disc; Female; Leucine; Male; Microsomes, Liver; Osmolar Concentration; Phenylalanine; Polynucleotides; Potassium Chloride; Protein Conformation; Proteins; Rana esculenta; Rats; Species Specificity; Trypsin; Uracil Nucleotides | 1971 |
Effects of -radiation on concentrated solutions of -chymotrypsin.
Topics: Air; Albumins; Anilides; Carbamates; Caseins; Chymotrypsin; Cobalt Isotopes; Electrophoresis; Esters; Hemoglobins; Hydrochloric Acid; Imidazoles; Leucine; Nitro Compounds; Nitrogen; Nitrophenols; Peptides; Phenylalanine; Radiation Effects; Radiochemistry; Riboflavin; Solutions; Structure-Activity Relationship; Tryptophan; Tyrosine | 1972 |
Specificity-determining site of -chymotrypsin. I. Kinetic investigation of aromatic amino compounds and phenylalanine ester derivatives in -chymotrypsin-catalyzed hydrolysis.
Topics: Aniline Compounds; Benzene Derivatives; Binding Sites; Chymotrypsin; Esters; Hydrolysis; Kinetics; Models, Structural; Naphthalenes; Phenylalanine; Quinolines | 1972 |
Stereochemistry of the active site of -chymotrypsin. The influence of polar groups in locked substrates.
Topics: Acetamides; Anhydrides; Binding Sites; Carboxylic Acids; Chemical Phenomena; Chemistry; Chymotrypsin; Esters; Furans; Hydrolysis; Indenes; Kinetics; Maleates; Methanol; Models, Chemical; Models, Structural; Naphthalenes; Phenylalanine; Stereoisomerism; Structure-Activity Relationship | 1972 |
Magnetic resonance studies of protein-small molecule interactions. Binding of N-trifluoroacetyl-D-(and L-)-p-fluorophenylalanine to -chymotrypsin.
Topics: Chymotrypsin; Fluorine; Fluoroacetates; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Weight; Phenylalanine; Protein Binding | 1972 |
A comparison of the utilization of methyl and p-nitrophenyl esters in determining the specificity of -chymotrypsin.
Topics: Acetates; Alanine; Catalysis; Chymotrypsin; Glycine; Hydrolysis; Kinetics; Leucine; Methanol; Nitrophenols; Phenylalanine; Stereoisomerism; Structure-Activity Relationship; Tryptophan; Valine | 1972 |
A kinetic investigation of the crystallographically deduced binding subsites of bovine chymotrypsin A .
Topics: Acetates; Animals; Benzyl Compounds; Binding Sites; Catalysis; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Esters; Formates; Glycine; Kinetics; Mathematics; Methanol; Models, Chemical; Models, Structural; Peptides; Phenylalanine; Proline; Thermodynamics; Valine; X-Ray Diffraction | 1972 |
A chemical and crystallographic study of carbamyl-chymotrypsin A.
Topics: Acetates; Amino Acids; Animals; Binding Sites; Carbamates; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cyanates; Cyanides; Cyanogen Bromide; Cysteine; Glycine; Models, Structural; Nitrophenols; Pancreas; Phenylalanine; Protein Conformation; Serine; Succinates; Water; X-Ray Diffraction | 1972 |
Conformational energy calculations of enzyme-substrate interactions. I. Computation of preferred conformations of some substrates of -chymotrypsin.
Topics: Chymotrypsin; Phenylalanine; Protein Conformation; Tryptophan; Tyrosine | 1972 |
Conformational energy calculations of enzyme-substrate interactions. II. Computation of the binding energy for substrates in the active site of -chymotrypsin.
Topics: Binding Sites; Chymotrypsin; Phenylalanine; Protein Binding; Protein Conformation; Tryptophan; X-Ray Diffraction | 1972 |
Exposure of proteins and lipids in the Semliki forest virus membrane.
Topics: Autoradiography; Chromatography, Thin Layer; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Lipids; Nucleoproteins; Peptides; Phenylalanine; Phospholipids; Semliki forest virus; Sodium Dodecyl Sulfate; Sulfones; Sulfur Isotopes; Surface-Active Agents; Tritium; Trypsin; Viral Proteins | 1972 |
-chymotrypsin: selective hydrolysis of tyrosyl-tRNA Tyr and phenylalanyl-tRNA Phe .
Topics: Chymotrypsin; Hydrolysis; Phenylalanine; RNA, Transfer; Tyrosine | 1971 |
Amino acid sequence of bovine carboxypeptidase A. Tryptic and chymotryptic peptides of the cyanogen bromide fragment F-I.
Topics: Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Cyanides; Cysteine; Electrophoresis; Hydrogen-Ion Concentration; Hydrolysis; Leucyl Aminopeptidase; Peptides; Phenylalanine; Solubility; Thiocyanates; Trypsin | 1971 |
Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.
Topics: Acylation; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chlorine; Chymotrypsin; Chymotrypsinogen; Crystallography; Electrons; Histidine; Isoleucine; Ketones; Mathematics; Models, Structural; Peptides; Phenylalanine; Serine; X-Ray Diffraction | 1971 |
The chymotrypsinogens and procarboxypeptidases of chick pancreas.
Topics: Acetates; Amylases; Animals; Benzoates; Carboxypeptidases; Chickens; Chromatography, DEAE-Cellulose; Chymotrypsin; Chymotrypsinogen; Endopeptidases; Enzyme Activation; Enzyme Precursors; Hippurates; Lactates; Leucine; Lipase; Methanol; Pancreas; Phenylalanine; Trypsin; Trypsinogen; Tryptophan; Tyrosine | 1971 |
The reactivity of His-57 in chymotrypsin to alkylation.
Topics: Acetates; Alkylation; Benzyl Compounds; Bromine; Chemical Phenomena; Chemistry; Chlorine; Chymotrypsin; Formates; Histidine; Ketones; Kinetics; Phenylalanine; Sulfonic Acids; Toluene | 1971 |
Kinetic properties of succinylated and ethylenediamine-amidated -chymotrypsins.
Topics: Acetates; Acrylates; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Chymotrypsinogen; Computers; Enzyme Activation; Ethylenediamines; Furans; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Imides; Isoleucine; Kinetics; Methylamines; Phenylalanine; Protein Conformation; Succinates; Trypsin; Tryptophan | 1971 |
Mechanism of the -chymotrypsin-catalyzed hydrolysis of amides. pH dependence of k c and K m . Kinetic detection of an intermediate.
Topics: Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Phenylalanine; Protein Binding; Solubility | 1971 |
Enzymatic resolution. An organic-biochemical laboratory experiment.
Topics: Animals; Catalysis; Chemistry; Chymotrypsin; Kidney; Methods; Phenylalanine; Stereoisomerism; Swine | 1971 |
Catalytic properties of oligomeric -chymotrypsin.
Topics: Acetates; Anilides; Animals; Catalysis; Cattle; Chymotrypsin; Glutarates; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Mathematics; Nitro Compounds; Osmolar Concentration; Phenylalanine; Succinates; Temperature; Tyrosine; Ultracentrifugation | 1971 |
In vitro studies on the mechanism of suppression of a nonsense mutation.
Topics: Autoradiography; Chromatography, Gel; Chymotrypsin; Coliphages; In Vitro Techniques; Lysine; Molecular Biology; Mutation; Phenylalanine; RNA, Transfer; Viral Proteins | 1965 |
[Determination of the capacity of trypsin and chymotrypsin inhibition of normal human serum].
Topics: Anilides; Anticoagulants; Arginine; Calcium Chloride; Chymotrypsin; Hot Temperature; Humans; Osmolar Concentration; Phenylalanine; Protein Denaturation; Sodium Chloride; Spectrophotometry; Time Factors; Trypsin Inhibitors | 1969 |
Alpha-keto analogues of amino acids as inhibitors of alpha-chymotrypsin, carboxypeptidase A, and pepsin.
Topics: Caproates; Carboxypeptidases; Chymotrypsin; Enzymes; Indoleacetic Acids; Indoles; Keto Acids; Ketoglutaric Acids; Kinetics; Lactates; Pepsin A; Phenylalanine; Phenylpyruvic Acids; Propionates; Pyruvates; Tryptophan; Tyrosine | 1965 |
Amino acid changes provoked by streptomycin in a polypeptide synthesized in vitro.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chemistry Techniques, Analytical; Chromatography, Paper; Chymotrypsin; Escherichia coli; In Vitro Techniques; Isoleucine; Peptide Biosynthesis; Phenylalanine; Radiometry; Ribosomes; Streptomycin; Tritium; Uracil Nucleotides | 1965 |
[Adjustment of the substrate as rate-determining step in the enzymatic cleavage of esters and amides by chymotrypsin A].
Topics: Acridines; Amides; Chemical Phenomena; Chemistry; Chymotrypsin; Esters; Fluoroacetates; Kinetics; Magnetic Resonance Spectroscopy; Phenylalanine; Temperature; Tyrosine | 1969 |
Properties of colostrokinin from bovine colostrum.
Topics: Acetone; Amino Acids; Animals; Blood; Bradykinin; Capillary Permeability; Cattle; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Chymotrypsin; Colostrum; Dialysis; Dogs; Electrophoresis; Ethanol; Female; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Ileum; Immunoglobulins; Kinins; Lactoglobulins; Molecular Weight; Muscle Contraction; Paper; Phenylalanine; Rats; Serine; Solubility; Spectrophotometry; Trypsin; Uterus; Vasodilator Agents | 1969 |
Cerebral proteinases in the growing rat.
Topics: Animals; Arginine; Brain; Centrifugation; Chymotrypsin; Hydrogen-Ion Concentration; Nerve Tissue Proteins; Phenylalanine; Protein Denaturation; Rats; Spectrophotometry; Trypsin; Tyrosine | 1970 |
Alpha-chymotrypsin. The use of substrates of restricted geometry to define the reactive conformation of methyl N-acetyl-l-phenylalaninate.
Topics: Chymotrypsin; Esters; Models, Chemical; Phenylalanine | 1970 |
Enzyme-inhibitor interactions studied via fluorine magnetic resonance. II. Model for the trifluoroacetylphenylalanine-alpha-chymotrypsin interaction.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chymotrypsin; Fluorine; Fluoroacetates; Magnetic Resonance Spectroscopy; Phenylalanine | 1970 |
[Evolution of endopeptidases. XI. A protease with chymotryptic specificity from the gastric juice of Sepia officinalis (cuttlefish)].
Topics: Animals; Arginine; Bromides; Chromatography, Ion Exchange; Chymotrypsin; Electrophoresis; Esters; Gastric Juice; Insulin; Molecular Weight; Mollusca; Naphthaleneacetic Acids; Peptide Hydrolases; Peptides; Phenylalanine; Phosphates; Sodium Chloride; Tyrosine | 1970 |
Tumorigenesis in mouse skin: inhibition by synthetic inhibitors of proteases.
Topics: Animals; Antineoplastic Agents; Arginine; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Chymotrypsin; Croton Oil; Depression, Chemical; Esters; Ketones; Lysine; Mice; Papain; Phenylalanine; Skin Neoplasms; Terpenes; Trypsin Inhibitors | 1970 |
On the active site of alpha-chymotrypsin. Cyclized and noncyclized substrates with tetrasubstituted alpha carbon atoms.
Topics: Benzene Derivatives; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Coumarins; Esters; Isoquinolines; Kinetics; Lactates; Methionine; Methods; Models, Structural; Optical Rotatory Dispersion; Phenylalanine; Propionates; Stereoisomerism | 1970 |
The interaction of alpha-chymotrypsin with phenylalanine derivatives containing a free alpha-amino group.
Topics: Catalysis; Chymotrypsin; Esters; Hydrogen-Ion Concentration; Kinetics; Methods; Phenylalanine | 1970 |
[Properties of a chymotrypsin-like N-acylamino acid esterase of rat's serum].
Topics: Amino Acids; Animals; Arginine; Chemical Precipitation; Chromatography, Gel; Chymotrypsin; Electrophoresis; Esterases; Esters; Phenylalanine; Rats; Tyrosine | 1970 |
[The action of peptidase beta from brewer's yeast on the B chain of oxidized insulin].
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chromatography, Paper; Chymotrypsin; Electrophoresis; Insulin; Leucine; Peptide Hydrolases; Phenylalanine; Saccharomyces; Tyrosine | 1970 |
Investigation of enzyme kinetics by oscillographic polarography.
Topics: Anilides; Binding Sites; Chymotrypsin; Kinetics; Methods; Nitrobenzenes; Nitrophenols; Oscillometry; Phenylalanine; Polarography; Spectrophotometry | 1970 |
Chymotrypsin-catalyzed phenyl ester hydrolysis. Evidence for electrophilic assistance on carbonyl oxygen.
Topics: Acylation; Catalysis; Chymotrypsin; Esters; Hippurates; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mathematics; Models, Biological; Osmolar Concentration; Phenols; Phenylalanine; Spectrophotometry; Sulfonamides; Temperature; Ultraviolet Rays | 1970 |
The susceptibility of N-acetyl-S-alkyl- and N-acetyl-S-aryl-cysteine ethyl esters to chymotryptic hydrolysis.
Topics: Acetates; Alkanes; Amines; Animals; Benzene Derivatives; Butylamines; Caproates; Cattle; Chymotrypsin; Cysteine; Esters; Kinetics; Methionine; Pancreas; Phenylalanine; Tryptophan; Tyrosine; Valerates | 1970 |
Laser-excited Raman spectroscopy of biomolecules. II. Native ribonuclease and alpha-chymotrypsin.
Topics: Amides; Amino Acids; Animals; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Cystine; Deuterium; Glutamates; Histidine; Hydrogen-Ion Concentration; Lasers; Muramidase; Peptides; Phenylalanine; Protein Denaturation; Ribonucleases; Spectrum Analysis; Sulfides; Tryptophan; Tyrosine | 1970 |
A sensitive fluorometric assay for alpha-chymotrypsin.
Topics: Chymotrypsin; Fluorometry; Hydrogen-Ion Concentration; Naphthalenes; Phenylalanine; Spectrophotometry | 1971 |
Fluorescence quenching due to mercuric ion interaction with aromatic amino acids and proteins.
Topics: Benzoates; Chemical Phenomena; Chemistry; Chymotrypsin; Energy Transfer; Enzyme Precursors; Fluorescence; Indoles; Lactoglobulins; Mercury; Nitrates; Ovalbumin; Phenylalanine; Serum Albumin; Spectrophotometry; Tryptophan; Tyrosine; Ultraviolet Rays | 1971 |
Properties of the isoleucyl amino-terminus of alpha-chymotrypsin.
Topics: Amino Acid Sequence; Anhydrides; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Electrophoresis; Hydrogen-Ion Concentration; Isoleucine; Peptides; Phenylalanine; Potassium Chloride; X-Ray Diffraction | 1971 |
Investigations of the chymotrypsin-catalyzed hydrolysis of specific substrates. V. Determination of pre-steady state kinetic parameters for specific substrate esters by stopped flow techniques.
Topics: Acridines; Amides; Arginine; Chemical Phenomena; Chemistry; Chymotrypsin; Esters; Ethanol; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Leucine; Methanol; Phenylalanine; Protein Binding; Spectrophotometry; Tryptophan; Tyrosine | 1971 |
Comparative studies on the primary structure of soluble and mitochondrial glutamic oxaloacetic transaminase isozymes. II. Amino acid sequence of the amino terminal fragments.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Aminobutyrates; Animals; Aspartate Aminotransferases; Chemical Phenomena; Chemistry; Chromatography, Paper; Chymotrypsin; Cyanides; Endopeptidases; Glutamates; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Hydroxybutyrates; Isoenzymes; Mitochondria, Muscle; Myocardium; Peptides; Phenylalanine; Proline; Serine; Solubility; Swine; Thiocyanates; Tryptophan; Valine | 1971 |
[Platelet reactions and immune processes. V. Inhibition by substrates and chymotrypsin inhibitors of ADP liberation by platelets].
Topics: Adenine Nucleotides; Blood Platelets; Chymotrypsin; Cinnamates; Collagen; Esters; Humans; Isoquinolines; Mast Cells; Phenols; Phenylalanine; Phenylbutazone; Platelet Adhesiveness; Tryptophan | 1971 |
The use of proteolytic enzymes in the study of ribosomal structure.
Topics: Amino Acids; Animals; Centrifugation, Density Gradient; Chymotrypsin; Densitometry; Electrophoresis, Disc; Female; In Vitro Techniques; Liver; Male; Micromanipulation; Phenylalanine; Proteins; Rats; Ribosomes; Spectrophotometry; Trypsin; Uracil Nucleotides | 1968 |
The active site in alpha-chymotrypsin. Absolute configuration and kinetics of hydrolysis of methyl 3,4-dihydroisocoumarin-3-carboxylate.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Coumarins; Kinetics; Models, Structural; Phenylalanine | 1968 |
Enzyme-inhibitor interactions studies via fluorine nuclear magnetic resonance. I. The interaction of alpha-chymotrypsin with DL-N-trifluoroacetylphenylalanie.
Topics: Chymotrypsin; Fluorine; Magnetic Resonance Spectroscopy; Phenylalanine; Radioisotopes; Sodium Chloride; Solvents | 1968 |
Structural analysis of the glycine-rich, arginine-rich histone. I. Sequence of the carbosyl-terminal portion.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Bromine; Carboxypeptidases; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Electrophoresis; Glycine; Histones; Peptides; Phenylalanine; Serine; Thymus Gland; Trypsin; Tyrosine | 1968 |
Calf and pea histone IV. I. Amino acid compositions and the identical COOH-terminal 19-residue sequence.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Evolution; Bromine; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Plants; Proline; Serine; Threonine; Trypsin; Tyrosine; Valine | 1968 |
A NMR study of the interaction of N-trifluoroacetyl-D-phenylalanine with alpha-chymotrypsin.
Topics: Binding Sites; Chymotrypsin; Fluoroacetates; Magnetic Resonance Spectroscopy; Phenylalanine | 1968 |
[On the evolution of endopeptidases. VII. A protease of molecular weight 12500 with chymotryptic properties from larvae of Vespa orientalis].
Topics: Animals; Chromatography, Gel; Chymotrypsin; Electrophoresis; Esters; Insecta; Intestines; Methyl Chloride; Molecular Weight; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Sulfonic Acids; Tyrosine | 1969 |
Isolation and properties of some reptilian and fish chymotrypsins.
Topics: Alkylating Agents; Amino Acids; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Drug Stability; Electrophoresis; Enzyme Precursors; Fishes; Hydrogen-Ion Concentration; Kinetics; Leucine; Lizards; Pancreas; Phenylalanine; Reptiles; Snakes; Species Specificity; Swine; Trypsin; Turtles | 1969 |
Identification of histidine in the active center of chymotrypsins from a reptile and a fish.
Topics: Alkylating Agents; Amino Acids; Animals; Autoanalysis; Binding Sites; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Fishes; Histidine; Pancreas; Phenylalanine; Species Specificity; Turtles | 1969 |
An application of transient nuclear magnetic resonance methods to the measurement of biological exchange rates. The interaction of trifluoroacetyl-D-phenylalanine with the chymotrypsins.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Fluorine; Magnetic Resonance Spectroscopy; Methods; Phenylalanine; Protein Binding | 1969 |
Investigations of the chymotrypsin-catalyzed hydrolysis of specific substrates. IV. Pre-steady state kinetic approaches to the investigation of the catalytic hydrolysis of esters.
Topics: Acridines; Amides; Amino Acids; Chymotrypsin; Computers, Analog; Esters; Hydrogen-Ion Concentration; Kinetics; Methods; Nitrophenols; Oscillometry; Phenylalanine; Spectrophotometry; Tryptophan; Tyrosine | 1969 |
[Structure of peptides isolated from chymotrypsin hydrolysates of horse myoglobin].
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Carboxypeptidases; Chromatography, Gel; Chymotrypsin; Dinitrophenols; Histidine; Horses; Leucyl Aminopeptidase; Methionine; Myoglobin; Peptides; Phenylalanine; Tryptophan; Tyrosine | 1969 |
[Alkylation of histidine radicals in the active center of horse myoglobin].
Topics: Acetates; Alkylation; Animals; Chymotrypsin; Histidine; Horses; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Myoglobin; Phenylalanine; Protein Denaturation | 1965 |
A new test for the quantitative determination of chymotrypsin, chymotrypsin-like enzymes and their inhibitors.
Topics: Animals; Chymotrypsin; Enzymes; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kinetics; Liver; Naphthalenes; Phenylalanine; Rats; Subcellular Fractions | 1965 |
Purification and properties of a mast cell protease.
Topics: Animals; Centrifugation; Chymotrypsin; Enzymes; Fibrinogen; Hemoglobins; In Vitro Techniques; Isoflurophate; Mast Cells; Peptide Hydrolases; Phenylalanine; Rats; Thyroglobulin; Thyroid Gland; Tyrosine | 1966 |
The action of chymotrypsin on two new chromogenic substrates.
Topics: Anilides; Calcium; Chemical Phenomena; Chemistry; Chymotrypsin; Kinetics; Phenylalanine; Sodium | 1966 |
A chymotrypsin-like protease from the rat submandibular gland.
Topics: Amino Acids; Anilides; Animals; Calcium Chloride; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Gel; Chymotrypsin; Electrophoresis; Hydrazines; Hydrogen-Ion Concentration; Male; Molecular Weight; Naphthalenes; Peptide Hydrolases; Phenylalanine; Rats; Submandibular Gland; Tyrosine | 1966 |
Studies of the effect of proteolytic enzymes on ribosomes and polysomes from reticulocytes and rat liver.
Topics: Animals; Centrifugation, Density Gradient; Chymotrypsin; In Vitro Techniques; Liver; Phenylalanine; Polynucleotides; Rats; Reticulocytes; Ribosomes; RNA, Messenger; Trypsin; Uracil Nucleotides | 1966 |
The hydrolysis of phenylalanine methyl ester by bovine thrombin.
Topics: Animals; Calcium; Cattle; Cellulose; Chromatography; Chymotrypsin; Citrates; Factor V; Phenylalanine; Phospholipids; Prothrombin; Thrombin; Trypsin Inhibitors; Tyrosine | 1966 |
Composition and mass of peptides released during tryptic and chymotryptic hydrolysis of myosin.
Topics: Arginine; Chromatography, Gel; Chymotrypsin; Kinetics; Lysine; Muscle Proteins; Peptides; Phenylalanine; Proline; Trypsin; Tyrosine | 1967 |
Investigations of the chymotrypsin-catalyzed hydrolysis of specific substrates. II. Characterization of the spectral changes of the enzyme at 290 m-mu and determination of over-all enzyme-substrate dissociation constants.
Topics: Amides; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Phenylalanine; Spectrophotometry; Ultraviolet Rays | 1967 |
Investigations of the chymotrypsin-catalyzed hydrolysis of specific substrates. 3. Determination of individual rate constants and enzyme-substrate binding constants for specific amide and ester substrates.
Topics: Acridines; Amides; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Hydrogen-Ion Concentration; Kinetics; Phenylalanine; Spectrophotometry; Tryptophan | 1967 |
Specificity and stereospecificity of alpha-chymotrypsin.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Glycine; Hydrogen-Ion Concentration; Kinetics; Leucine; Models, Chemical; Nitrophenols; Phenylalanine; Tryptophan | 1967 |
Enzyme--substrate interaction by nuclear magnetic resonance.
Topics: Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Fluorine; Magnetic Resonance Spectroscopy; Phenylalanine | 1967 |
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Topics: Chymotrypsin; Granulocytes; Granulomatous Disease, Chronic; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Naphthol AS D Esterase; Pancreatic Elastase; Peroxidase; Phenylalanine | 1983 |
Kinetic studies on the chymotrypsin A alpha-catalyzed hydrolysis of a series of N-acetyl-L-phenylalanyl peptides.
Topics: Amidohydrolases; Animals; Catalysis; Cattle; Chymotrypsin; Hydrolysis; Kinetics; Pancreas; Peptide Hydrolases; Peptides; Phenylalanine; Substrate Specificity; Temperature | 1983 |
Hydrolysis of phenylthiazolones of p-guanidinophenylalanine and arginine by trypsin and related enzymes.
Topics: Arginine; Chymotrypsin; Endopeptidases; Indicators and Reagents; Kinetics; Papain; Phenylalanine; Pronase; Substrate Specificity; Thrombin; Trypsin | 1983 |
Chymotrypsin modified with polyethylene glycol catalyzes peptide synthesis reaction in benzene.
Topics: Animals; Benzene; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Enzyme Activation; Peptide Biosynthesis; Phenylalanine; Polyethylene Glycols; Solubility; Trypsin; Tyrosine | 1984 |
Resistance of the peptidyltransferase centre of rabbit ribosomes to attack by nucleases and proteinases.
Topics: Acyltransferases; Animals; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Peptidyl Transferases; Phenylalanine; Polyribosomes; Rabbits; Ribonuclease T1; Ribonucleases; Ribosomal Proteins; Ribosomes; Trypsin | 1980 |
Ligand effects on the limited proteolysis of phenylalanine hydroxylase: evidence for multiple conformational states.
Topics: Animals; Binding Sites; Biopterins; Chymotrypsin; Kinetics; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Protein Binding; Protein Conformation; Rats; Rats, Inbred Strains | 1983 |
Synthesis of low-phenylalanine polypeptides.
Topics: Amino Acids; Carboxypeptidases; Carboxypeptidases A; Child; Chymotrypsin; Dietary Proteins; Glycine max; Humans; Peptides; Phenylalanine; Phenylketonurias; Plant Proteins | 1982 |
Enzymatic synthesis in biphasic aqueous-organic systems. I. Chemical equilibrium shift.
Topics: Alcohol Oxidoreductases; Animals; Butanols; Catalysis; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Horses; Hydrocarbons; Models, Chemical; Oxidation-Reduction; Phenylalanine; Solvents; Water | 1981 |
Proton and fluorine nuclear magnetic resonance spectroscopic observation of hemiacetal formation between N-acyl-p-fluorophenylalaninals and alpha-chymotrypsin.
Topics: Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Magnetic Resonance Spectroscopy; Pancreas; Phenylalanine; Protein Binding; Spectrophotometry, Infrared; Structure-Activity Relationship | 1982 |
Specificity in the hydrolysis of N-acyl-L-phenylalanine 4-nitroanilides by chymotrypsin.
Topics: Anilides; Animals; Cattle; Chymotrypsin; Kinetics; Phenylalanine; Substrate Specificity | 1980 |
Enzymatic synthesis in biphasic aqueous-organic systems. II. Shift of ionic equilibria.
Topics: Animals; Catalysis; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Dipeptides; Hydrocarbons; Hydrogen-Ion Concentration; Models, Chemical; Phenylalanine; Solvents; Water | 1981 |
Computation of enzyme-substrate specificity.
Topics: Amino Acid Sequence; Binding Sites; Chymotrypsin; Enzymes; Kinetics; Phenylalanine; Protein Binding; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Thermodynamics; Tryptophan | 1981 |
The kinetics of hydrolysis of some extended N-aminoacyl-L-phenylalanine methyl esters by bovine chymotrypsin A-alpha. Evidence for enzyme subsite S5.
Topics: Animals; Binding Sites; Catalysis; Cattle; Chymotrypsin; Hydrolysis; Kinetics; Peptides; Phenylalanine; Substrate Specificity; Temperature; Thermodynamics; Trypsin | 1981 |
[Synthesis of omega-carboxyacyl-L-phenylalanine-aryl esters and their use as substrates for cathepsin G and chymotrypsin].
Topics: Cathepsin G; Cathepsins; Chymotrypsin; Indicators and Reagents; Kinetics; Methods; Phenylalanine; Serine Endopeptidases; Spectrophotometry, Ultraviolet; Substrate Specificity | 1981 |
Interactions of derivatives of guanidinophenylglycine and guanidinophenylalanine with trypsin and related enzymes.
Topics: Animals; Cattle; Chymotrypsin; Glycine; Guanidines; Hydrolysis; Kinetics; Papain; Phenylalanine; Pronase; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Thrombin; Trypsin | 1980 |
Pressure effects on enzyme reactions in mainly organic media: alpha-chymotrypsin in reversed micelles of Aerosol OT in octane.
Topics: Animals; Catalysis; Cattle; Chymotrypsin; Dioctyl Sulfosuccinic Acid; Hydrolysis; Micelles; Octanes; Pancreas; Phenylalanine; Pressure; Surface-Active Agents; Tyrosine | 1994 |
[Solid-phase enzymatic reactions. V. Comparison of catalytic properties of subtilisin and alpha-chymotrypsin in the absence of a solvent].
Topics: Catalysis; Chymotrypsin; Humans; Hydrolysis; Immunoenzyme Techniques; Phenylalanine; Serine Proteinase Inhibitors; Solvents; Subtilisins; Water | 1995 |
Synthesis and characterization of a bioluminogenic substrate for alpha-chymotrypsin.
Topics: Chromatography, High Pressure Liquid; Chymotrypsin; Firefly Luciferin; Indicators and Reagents; Kinetics; Luminescent Measurements; Magnetic Resonance Spectroscopy; Phenylalanine; Sensitivity and Specificity; Substrate Specificity | 1994 |
The use of 13C n.m.r. and saturation transfer to detect tetrahedral intermediates in reactions catalysed by chymotrypsin and also in an amide inhibitor complex.
Topics: Binding Sites; Carbon Isotopes; Chymotrypsin; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Phenylalanine; Protease Inhibitors; Semicarbazides | 1994 |
Labeling of the active site of alpha-chymotrypsin with N-nitroso-N-benzylacetamide and related compounds.
Topics: Acetamides; Alanine; Benzeneacetamides; Benzyl Compounds; Binding Sites; Chymotrypsin; Magnetic Resonance Spectroscopy; Nitroso Compounds; Phenylalanine; Structure-Activity Relationship | 1993 |
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.
Topics: Adult; alpha 1-Antitrypsin; Animals; Cattle; Chymotrypsin; Homozygote; Humans; Liver Diseases; Male; Microscopy, Electron; Models, Molecular; Mutation; Phenylalanine; Polymers; Serine | 1993 |
Characterization of the 46-kDa intermediates of matrix metalloproteinase 3 (stromelysin 1) obtained by site-directed mutation of phenylalanine 83.
Topics: alpha-Macroglobulins; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Chymotrypsin; Cloning, Molecular; Cricetinae; Enzyme Activation; Enzyme Precursors; Glycoproteins; Hydrolysis; Kinetics; Leukocyte Elastase; Matrix Metalloproteinase 3; Metalloendopeptidases; Molecular Sequence Data; Mutagenesis, Site-Directed; Pancreatic Elastase; Phenylalanine; Phenylmercuric Acetate; Recombinant Proteins; Substrate Specificity; Sulfhydryl Compounds; Tissue Inhibitor of Metalloproteinases; Trypsin | 1996 |
The synthesis and characterisation of a glyoxal inhibitor of chymotrypsin.
Topics: Chymotrypsin; Glyoxal; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Phenylalanine; Serine Proteinase Inhibitors | 1996 |
The immobilized porcine pancreatic exopeptidases and its application in casein hydrolysates debittering.
Topics: Ammonium Sulfate; Animals; Arginine; Caseins; Chitin; Chromatography, High Pressure Liquid; Chymotrypsin; Decapoda; Enzymes, Immobilized; Exopeptidases; Glutamine; Glutaral; Histidine; Humans; Hydrolysis; Leucine; Lysine; Pancreas; Peptide Hydrolases; Phenylalanine; Swine; Taste; Trypsin; Tyrosine | 1996 |
Generation of soluble and active subtilisin and alpha-chymotrypsin in organic solvents via hydrophobic ion pairing.
Topics: Binding Sites; Chymotrypsin; Circular Dichroism; Dioctyl Sulfosuccinic Acid; Enzyme Stability; Esterification; Kinetics; Mutation; Phenylalanine; Sodium Dodecyl Sulfate; Solubility; Solvents; Subtilisins; Surface-Active Agents | 1996 |
Endopeptidase activities of selected Porphyromonas spp., Prevotella spp. and Fusobacterium spp. of oral and non-oral origin.
Topics: Alanine; Aminopeptidases; Bacteroides; Chymotrypsin; Coumarins; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Fluorescent Dyes; Fusobacterium; Fusobacterium necrophorum; Humans; Indicators and Reagents; Lysine; Mouth; Oligopeptides; Pancreatic Elastase; Phenylalanine; Porphyromonas; Porphyromonas gingivalis; Prevotella; Proline; Tyrosine; Virulence | 1997 |
Long-range effects on dynamics in a temperature-sensitive mutant of trp repressor.
Topics: Amides; Bacterial Proteins; Chymotrypsin; Leucine; Nuclear Magnetic Resonance, Biomolecular; Operator Regions, Genetic; Phenylalanine; Point Mutation; Protons; Repressor Proteins; Spectrometry, Fluorescence; Temperature; Tryptophan | 1999 |
The differential specificity of chymotrypsin A and B is determined by amino acid 226.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cattle; Chymotrypsin; Glycine; Models, Molecular; Molecular Sequence Data; Mutagenesis; Phenylalanine; Protein Isoforms; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Serine Endopeptidases; Substrate Specificity; Tryptophan; Tyrosine | 1999 |
N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.
Topics: Animals; Binding, Competitive; Cattle; Chymotrypsin; Enzyme Reactivators; Humans; Hydrazines; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenylalanine; Structure-Activity Relationship; Trypsin Inhibitors | 1999 |
Electron nuclear double resonance determined structures of enzyme reaction intermediates: structural evidence for substrate destabilization.
Topics: Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Kinetics; Models, Molecular; Molecular Conformation; Phenylalanine; Spin Labels; Tryptophan | 1998 |
Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: synthesis of all four stereoisomers and their assay against serine proteases.
Topics: Chymotrypsin; Dipeptides; Humans; Leucine; Leukocyte Elastase; Phenylalanine; Serine Proteinase Inhibitors; Stereoisomerism; Succinimides | 1999 |
Synthesis of theophylline-polyrotaxane conjugates and their drug release via supramolecular dissociation.
Topics: alpha-Cyclodextrins; Bronchodilator Agents; Chemistry, Pharmaceutical; Chymotrypsin; Cyclodextrins; Delayed-Action Preparations; Drug Carriers; Ethylenediamines; Nitrophenols; Papain; Phenylalanine; Polyethylene Glycols; Polymers; Solubility; Theophylline | 1999 |
alpha-Chymotrypsin-catalyzed degradation of desmopressin (dDAVP): influence of pH, concentration and various cyclodextrins.
Topics: Chymotrypsin; Cyclodextrins; Deamino Arginine Vasopressin; Dose-Response Relationship, Drug; Drug Interactions; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Phenylalanine | 1999 |
Multiple forms of the major phenylalanine specific protease in Treponema denticola.
Topics: Actins; Bacterial Proteins; Blotting, Western; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Humans; Keratins; Peptide Hydrolases; Periodontal Pocket; Phenylalanine; Treponema | 1999 |
The contribution of residues 192 and 193 to the specificity of snake venom serine proteinases.
Topics: Amino Acid Sequence; Aprotinin; Batroxobin; Chymotrypsin; Crotalid Venoms; Dose-Response Relationship, Drug; Fibrinogen; Glycoproteins; Histidine; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Plasminogen; Plasminogen Activators; Recombinant Proteins; Sequence Homology, Amino Acid; Serine Endopeptidases; Structure-Activity Relationship; Substrate Specificity; Tissue Plasminogen Activator | 2000 |
Enantioselective ester hydrolysis catalyzed by imprinted polymers.
Topics: Catalysis; Catalytic Domain; Chymotrypsin; Esters; Hydrolysis; Indicators and Reagents; Kinetics; Molecular Conformation; Molecular Structure; Phenylalanine; Stereoisomerism | 2000 |
Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase.
Topics: Binding Sites; Biopterins; Chymotrypsin; Enzyme Activation; Models, Molecular; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Protein Conformation; Recombinant Proteins; Sequence Deletion | 2001 |
Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin.
Topics: Acetals; Anions; Binding Sites; Carbon Isotopes; Catalysis; Chymotrypsin; Crystallography, X-Ray; Hydrogen Bonding; Hydrogen-Ion Concentration; Macromolecular Substances; Nuclear Magnetic Resonance, Biomolecular; Phenylalanine; Serine Proteinase Inhibitors | 2001 |
Alpha-chymotrypsin catalysis in imidazolium-based ionic liquids.
Topics: 1-Propanol; Carbon Dioxide; Catalysis; Chymotrypsin; Esterification; Freeze Drying; Imidazoles; Kinetics; Phenylalanine; Solutions | 2001 |
Alpha-ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin.
Topics: Binding Sites; Biochemistry; Carbamates; Chymotrypsin; Drug Evaluation, Preclinical; Peptides; Phenylalanine; Photochemistry; Serine Proteinase Inhibitors; Structure-Activity Relationship; Ultraviolet Rays | 2001 |
The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.
Topics: Animals; Binding Sites; Cathepsin G; Cathepsins; Chymases; Chymotrypsin; Cysteine; Humans; Kinetics; Leukocyte Elastase; Myeloblastin; Pancreatic Elastase; Peptide Fragments; Phenylalanine; Prostate-Specific Antigen; Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Serpins; Substrate Specificity; Swine | 2001 |
Structural and conformational analysis of the oxidase to dehydrogenase conversion of xanthine oxidoreductase.
Topics: Animals; Cattle; Chromatography; Chromatography, High Pressure Liquid; Chymotrypsin; Cross-Linking Reagents; Cysteine; Disulfides; Electrophoresis, Gel, Two-Dimensional; Lysine; Methionine; Microscopy, Fluorescence; Oxidoreductases; Oxygen; Phenylalanine; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Sulfhydryl Compounds; Time Factors; Trypsin; Xanthine Dehydrogenase; Xanthine Oxidase | 2002 |
Identification of biodegradation products formed by L-phenylalanine based segmented polyurethaneureas.
Topics: Biocompatible Materials; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Chymotrypsin; Mass Spectrometry; Phenylalanine; Polyurethanes | 2002 |
Protease-catalyzed peptide synthesis for the site-specific incorporation of alpha-fluoroalkyl amino acids into peptides.
Topics: Amino Acids; Catalysis; Chymotrypsin; Fluoroacetates; Guanidines; Models, Molecular; Molecular Mimicry; Molecular Structure; Peptide Biosynthesis; Peptides; Phenylalanine; Protein Engineering; Trifluoroacetic Acid; Trypsin | 2003 |
Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.
Topics: alpha 1-Antitrypsin; Animals; Binding Sites; Carcinoma, Hepatocellular; Chymotrypsin; Crystallography, X-Ray; Cysteine; Fibrosis; Glycine; Hepatitis; Hepatocytes; Hydrogen-Ion Concentration; Models, Molecular; Mutation; Oocytes; Phenylalanine; Polymers; Potassium Chloride; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Temperature; Threonine; Time Factors; Xenopus | 2003 |
Two steps in the reaction of chymotrypsin with acetyl-L-phenylalanine ethyl ester.
Topics: Chymotrypsin; Endopeptidases; Hydrolases; Peptide Hydrolases; Phenylalanine | 1955 |
The action of chymotrypsin on N-alkyl derivatives of phenylalanine ethyl ester.
Topics: Chymotrypsin; Endopeptidases; Hydrolases; Peptide Hydrolases; Phenylalanine | 1957 |
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.
Topics: Amino Acids; Anti-Bacterial Agents; Biochemical Phenomena; Biochemistry; Chloramphenicol; Chromatography; Chymotrypsin; Electrophoresis; Enzyme Inhibitors; Escherichia coli; Peptides; Phenylalanine; Protein Biosynthesis; Proteins; Puromycin; Research; Ribosomes; RNA; RNA, Bacterial; Tritium; Trypsin; Tyrosine | 1964 |
INHIBITION OF TRYPSIN BY COPOLYMERS OF GLUTAMIC ACID AND OTHER AMINO ACIDS.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chymotrypsin; Colorimetry; Glutamates; Glutamic Acid; Leucine; Peptides; Phenylalanine; Research; Trypsin; Trypsin Inhibitors; Tyrosine; Urea | 1964 |
THE RESPONSE OF THREE CATALYTICALLY FUNCTIONAL GROUPS IN CHYMOTRYPSIN TO CHANGES IN ACIDITY.
Topics: Acids; Anilides; Catalysis; Chymotrypsin; Hydrogen-Ion Concentration; Imidazoles; Phenols; Phenylalanine; Research; Tyrosine | 1964 |
D-ASPARTYL-VALYL-PHENYLALANINE AMIDE ANGIOTENSIN II.
Topics: Angiotensin II; Angiotensins; Blood Pressure; Carboxypeptidases; Chemistry, Pharmaceutical; Chymotrypsin; Dipeptides; Guinea Pigs; Leucyl Aminopeptidase; Phenylalanine; Rats; Research; Trypsin | 1964 |
CHARACTERIZATION OF A REVERSIBLY FORMED ENZYME COMPLEX IN THE REACTION OF CHYMOTRYPSIN WITH DIISOPROPYL FLUOROPHOSPHATE.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Fluorides; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Multienzyme Complexes; Phenylalanine; Phosphates; Research; Spectrophotometry | 1965 |
COMPARATIVE BINDING PROPERTIES OF NATIVE AND ANHYDRO CHYMOTRYPSIN DETERMINED BY A COMPETITIVE DIALYSIS METHOD.
Topics: Acridines; Biochemical Phenomena; Biochemistry; Catalysis; Chymotrypsin; Dialysis; Phenylalanine; Propionates; Renal Dialysis; Research | 1965 |
OPHIDIAN L-AMINO ACID OXIDASE. THE NATURE OF THE ENZYME-SUBSTRATE COMPLEXES.
Topics: Alanine; Amino Acid Oxidoreductases; Amino Acids; Animals; Biochemical Phenomena; Biochemistry; Catalysis; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Glycine; Hydroquinones; Kinetics; L-Amino Acid Oxidase; Phenylalanine; Research; Snakes; Tryptophan; Venoms | 1965 |
SUPPRESSION OF A COAT PROTEIN MUTANT OF THE BACTERIOPHAGE F2.
Topics: Alkaline Phosphatase; Autoradiography; Capsid Proteins; Chymotrypsin; Coliphages; Dextrans; Genetic Code; Glutamine; Molecular Biology; Mutant Proteins; Mutation; Peptides; Phenylalanine; Proteins; Research; Serine; Viral Proteins | 1965 |
Effect of methanol and dioxan on the action of chymotrypsin on L-phenylalanine methyl ester.
Topics: Chymotrypsin; Dioxanes; Ethanol; Heterocyclic Compounds; Methanol; Phenylalanine | 1960 |
A despecialization step underlying evolution of a family of serine proteases.
Topics: Amino Acid Sequence; Animals; Catalysis; Chymotrypsin; Evolution, Molecular; Granzymes; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Phylogeny; Plasmids; Point Mutation; Protein Binding; Rats; Recombinant Proteins; Serine Endopeptidases; Sheep; Substrate Specificity; Time Factors; Trypsin | 2003 |
Biodegradation of amino-acid-based poly(ester amide)s: in vitro weight loss and preliminary in vivo studies.
Topics: Absorbable Implants; Amino Acids; Animals; Biodegradation, Environmental; Carica; Chymotrypsin; Cysteine Endopeptidases; Dicarboxylic Acids; Enzymes, Immobilized; Glycols; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Implants, Experimental; Kinetics; Leucine; Lipase; Molecular Structure; Molecular Weight; Phenylalanine; Polyesters; Potentiometry; Rats; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Substrate Specificity; Surface Properties; Viscosity | 2004 |
A simple method to determine trypsin and chymotrypsin inhibitory activity.
Topics: Chymotrypsin; Colorimetry; Enzyme Inhibitors; Phenylalanine; Pichia; Recombinant Proteins; Serine Endopeptidases; Trypsin; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors | 2004 |
Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.
Topics: Amino Acid Sequence; Animals; Azides; Blotting, Western; CHO Cells; Chymotrypsin; Cricetinae; Cross-Linking Reagents; Diabetes Mellitus; Dimerization; Disulfides; Exons; Humans; Insulin; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutation; Phenylalanine; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptor, Insulin; Sequence Homology, Amino Acid; Trypsin; Ultraviolet Rays | 2004 |
Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.
Topics: Catalysis; Chymotrypsin; Enzymes; Enzymes, Immobilized; Ibuprofen; Lipase; Macromolecular Substances; Membranes, Artificial; Phenylalanine; Stereoisomerism; Surface-Active Agents | 2004 |
Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide.
Topics: Amino Acid Sequence; Amino Acids; Animals; Biological Assay; Chromatography, High Pressure Liquid; Chymotrypsin; Conotoxins; Disulfides; Electrophysiology; Endopeptidases; Mass Spectrometry; Metalloendopeptidases; Mice; Molecular Sequence Data; Muscles; Oxygen; Peptides; Phenylalanine; Protein Conformation; Protein Folding; Protein Isoforms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Rana pipiens; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2005 |
Examples of peptide-peptoid hybrid serine protease inhibitors based on the trypsin inhibitor SFTI-1 with complete protease resistance at the P1-P1' reactive site.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Chymotrypsin; Glycine; Lysine; Membrane Proteins; Peptides; Peptoids; Phenylalanine; Qc-SNARE Proteins; Saccharomyces cerevisiae Proteins; Serine Proteinase Inhibitors; Structure-Activity Relationship; Trypsin; Trypsin Inhibitors | 2005 |
Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition.
Topics: Animals; Cattle; Chymotrypsin; Crystallography, X-Ray; Escherichia coli; Factor VIIa; Fibrinolysin; Glycoproteins; Humans; Leucine; Models, Molecular; Neoplasm Metastasis; Oxygen; Phenylalanine; Protease Inhibitors; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Static Electricity; Trypsin | 2005 |
Optical resolution of various amino acids using a supported liquid membrane encapsulating a surfactant-protease complex.
Topics: Amino Acids; Animals; Cattle; Chymotrypsin; Enzymes, Immobilized; Ethanol; In Vitro Techniques; Membranes, Artificial; Optics and Photonics; Peptide Hydrolases; Phenylalanine; Solvents; Stereoisomerism; Surface Properties; Surface-Active Agents | 2005 |
Noncovalent modification of chymotrypsin surface using an amphiphilic polymer scaffold: implications in modulating protein function.
Topics: Animals; Cattle; Chymotrypsin; Circular Dichroism; Hydrophobic and Hydrophilic Interactions; Kinetics; Micelles; Molecular Conformation; Phenylalanine; Polymers; Protein Binding; Spectrometry, Fluorescence; Substrate Specificity; Surface Properties | 2005 |
Application of 2D-fluorescence spectroscopy for on-line monitoring of pseudoenantiomeric transformations in supercritical carbon dioxide systems.
Topics: Carbon Dioxide; Chymotrypsin; Hydrolysis; Isomerism; Online Systems; Phenylalanine; Spectrometry, Fluorescence; Substrate Specificity; Temperature | 2005 |
Substrate monolayers as electrochemical sensing elements for alpha-chymotrypsin.
Topics: Anilides; Chymotrypsin; Disulfides; Electrochemistry; Electrodes; Fatty Acids; Gold; Phenylalanine; Spectrophotometry, Infrared | 2002 |
A simple procedure for the photoregulation of chymotrypsin activity.
Topics: Animals; Cattle; Chymotrypsin; Enzyme Activation; Ethanol; Molecular Structure; Nitrobenzenes; Phenylalanine; Photochemistry; Serum Albumin, Bovine; Tyrosine; Ultraviolet Rays | 2006 |
Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage.
Topics: Antineoplastic Agents; Chymotrypsin; Drug Design; Drug Stability; Enzyme Activators; Half-Life; Molecular Conformation; Peptide Hydrolases; Phenylalanine; Phosphoramide Mustards; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 2007 |
Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).
Topics: Amino Acid Sequence; Animals; Cattle; Chymotrypsin; Enzyme Inhibitors; Kinetics; Molecular Sequence Data; Phenylalanine; Substrate Specificity | 2008 |
Biomolecular adsorption behavior on spherical carbon aerogels with various mesopore sizes.
Topics: Adsorption; Carbon; Chymotrypsin; Formaldehyde; Gels; Organic Chemicals; Particle Size; Phenols; Phenylalanine; Polymers; Porosity; Serum Albumin, Bovine; Triazines; Vitamin B 12 | 2009 |
Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.
Topics: Catalytic Domain; Chymotrypsin; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Phenylalanine; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Structure-Activity Relationship | 2010 |
Synthesis, characterization and biodegradation of functionalized amino acid-based poly(ester amide)s.
Topics: Allylglycine; Amides; Amino Acids; Benzenesulfonates; Biocompatible Materials; Biodegradation, Environmental; Chymotrypsin; Dicarboxylic Acids; Esters; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Phenylalanine; Solubility; Spectroscopy, Fourier Transform Infrared; Sulfhydryl Compounds; Surface Properties; Temperature; Time Factors | 2010 |
Effect of crowding by dextrans on the hydrolysis of N-Succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin.
Topics: Biocatalysis; Chymotrypsin; Dextrans; Hydrolysis; Kinetics; Phenylalanine; Thermodynamics | 2011 |
Chymotrypsin-like serine proteinases are involved in the maintenance of cell viability.
Topics: Apoptosis; Biological Transport; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival; Chymotrypsin; Dose-Response Relationship, Drug; HeLa Cells; Humans; Microscopy, Confocal; Organophosphonates; Phenylalanine; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Rhodamines; Serine Proteases; Serine Proteinase Inhibitors | 2012 |
Enzymatic production and degradation of cheese-derived non-proteolytic aminoacyl derivatives.
Topics: Carboxypeptidases; Cheese; Chymotrypsin; Dipeptides; gamma-Glutamyltransferase; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Lactic Acid; Pepsin A; Phenylalanine; Proteolysis; Trypsin | 2014 |
Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach.
Topics: Animals; Chymotrypsin; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Docking Simulation; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Phenylalanine; Protease Inhibitors; Protons; Solutions; Static Electricity; Stereoisomerism; Swine; Valine | 2015 |
The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery.
Topics: Alanine; Chymotrypsin; Dopamine; Drug Delivery Systems; Hydrolysis; Micelles; Pancreatic Elastase; Peptides; Phenylalanine; Polymerization; Sarcosine; Thermolysin | 2015 |
Enzyme activity of α-chymotrypsin: Deactivation by gold nano-cluster and reactivation by glutathione.
Topics: Chymotrypsin; Circular Dichroism; Glutathione; Gold; Metal Nanoparticles; Phenylalanine | 2017 |
Co-solvent effects on reaction rate and reaction equilibrium of an enzymatic peptide hydrolysis.
Topics: Animals; Calcium Chloride; Cattle; Chymotrypsin; Dimethyl Sulfoxide; Hydrolysis; Kinetics; Methylamines; Phenylalanine; Sodium Chloride; Solvents; Thermodynamics; Urea; Water | 2018 |
A novel three-fluorophore system as a ratiometric sensor for multiple protease detection.
Topics: Aminocoumarins; Chymotrypsin; Drug Stability; Enzyme Assays; Fluoresceins; Fluorescence; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Hydrolysis; Lysine; Phenylalanine; Rhodamines; Trypsin | 2018 |
Exfoliated Nanosheets of a Cu
Topics: Animals; Binding Sites; Catalysis; Cell Survival; Chymotrypsin; Coordination Complexes; Copper; Histidine; Kinetics; Mice; Models, Molecular; Nanostructures; Osmolar Concentration; Phenylalanine; Phthalic Acids; Polymers; Protein Conformation; RAW 264.7 Cells | 2018 |
Combined co-solvent and pressure effect on kinetics of a peptide hydrolysis: an activity-based approach.
Topics: Chymotrypsin; Dimethyl Sulfoxide; Hydrolysis; Kinetics; Methylamines; Phenylalanine; Pressure; Solvents; Thermodynamics; Urea; Water | 2019 |