phenylalanine has been researched along with 4-boronophenylalanine in 204 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.96) | 18.7374 |
| 1990's | 66 (32.35) | 18.2507 |
| 2000's | 75 (36.76) | 29.6817 |
| 2010's | 49 (24.02) | 24.3611 |
| 2020's | 10 (4.90) | 2.80 |
| Authors | Studies |
|---|---|
| Hori, Y; Ichihashi, M; Komura, A; Mishima, Y; Shiono, M; Yamamura, K; Yoshino, K | 1 |
| Mishima, Y | 1 |
| Hatazawa, J; Honda, C; Ichihashi, M; Ido, T; Ishiwata, K; Kubota, K; Mishima, Y; Shiono, M; Yoshino, K | 1 |
| Allen, BJ; Corderoy-Buck, S; Crotty, K; Mallesch, JL; Moore, DE | 1 |
| Bennett, BD; Gay, I; Morrison, GH; Zha, X | 1 |
| Adelman, LS; Cano, G; Harling, OK; Joyce, MA; Kerley, SE; Madoc-Jones, H; Saris, SC; Solares, GR; Wazer, DE; Zamenhof, RG | 1 |
| Coderre, JA; Joel, DD; Micca, PL; Nawrocky, MM; Slatkin, DN | 1 |
| Hatanaka, H; Komada, F; Mishima, Y; Okumura, K; Shiono, M | 1 |
| Coderre, J; Fairchild, R; Hansrote, J; Packer, S; Perry, H; Saraf, S | 1 |
| Ichihashi, M; Ido, T; Ishiwata, K; Mejia, AA; Mishima, Y | 1 |
| Ciallella, JR; Coderre, JA; Micca, PL; Slatkin, DN | 1 |
| Fukuda, H; Hiratsuka, J; Imajo, Y; Karashima, H; Kobayashi, T; Mishima, Y; Yoshino, K | 1 |
| Hatta, S; Honda, C; Ichihashi, M; Mishima, Y | 1 |
| Coderre, JA; Glass, JD; Greenberg, D; Micca, P; Packer, S | 1 |
| Barth, RF; Fairchild, RG; Soloway, AH | 1 |
| Coderre, JA; Fairchild, RG; Fand, I; Glass, JD; Joel, DD; Micca, PL | 1 |
| Hiratsuka, J; Kono, M; Mishima, Y | 1 |
| Coderre, JA; Cohen, S; Fairchild, RG; Fand, I; Glass, JD; Roy, U | 1 |
| Ichihashi, M; Mishima, Y; Tsuji, M | 1 |
| Ichihashi, M; Mishima, Y; Nakanishi, T | 1 |
| Asao, N; Cai, J; Iwamoto, S; Nemoto, H; Yamamoto, Y | 1 |
| Bywaters, A; Coderre, JA; Hopewell, JW; Liu, HB; Micca, PL; Morris, GM; Nawrocky, MM | 1 |
| Allen, BJ; Halliday, GM; Harding, AJ; Moore, DE; Setiawan, Y | 1 |
| Honda, C; Ichihashi, M; Mishima, Y; Wadabayashi, N | 1 |
| Bennett, BD; Coderre, JA; Morrison, GH; Mumford-Zisk, J | 1 |
| Coderre, JA; Hopewell, JW; Micca, PL; Morris, GM; Rezvani, M | 1 |
| Feinendegen, LE; Müller-Gärtner, HW; Papaspyrou, M | 1 |
| Flam, F | 1 |
| Fukuda, H; Ichihashi, M; Mishima, Y | 1 |
| Bailey, MQ; Barth, RF; Coderre, JA; Matalka, KZ; Moeschberger, ML; Rofstad, EK; Soloway, AH; Staubus, AE | 2 |
| Bailey, MQ; Barth, RF; Hopewell, JW; Koestner, A; Matalka, KZ; Wilkie, DA | 1 |
| Allen, BJ; Jones, R; Mallesch, JL; McCarthy, WH; Moore, DE; Stening, WA | 1 |
| Abe, Y; Fukuda, H; Hiratsuka, J; Honda, C; Ichihashi, M; Kanda, K; Karashima, H; Kobayashi, T; Takahashi, J; Yoshino, K | 1 |
| Hatanaka, H; Komada, F; Mishima, Y; Okumura, K | 1 |
| Barth, RF; Coderre, JA; Matalka, KZ; Moeschberger, ML; Staubus, AE | 1 |
| Carlsson, J; Lindström, P; Olsson, P; Pettersson, OA; Sjöberg, S | 1 |
| Bartelink, H; Begg, AC; Gregoire, V; Huiskamp, R; Verrijk, R | 1 |
| Brownell, GL; Holden, SA; Nguyen, T; Teicher, BA | 1 |
| Allen, BJ | 1 |
| Ido, T; Ishiwata, K; Kubota, K; Kubota, R; Tada, M; Yamada, S | 1 |
| Chauvel, P; Pignol, JP | 1 |
| Cai, J; Iwamoto, S; Kikuchi, H; Nemoto, H; Oda, Y; Ono, K; Takagaki, M; Yamamoto, Y | 1 |
| Barth, RF; Carpenter, DE; Goodman, JH; Moeschberger, ML; Yang, W | 1 |
| Bywaters, A; Coderre, JA; Hopewell, JW; Morris, GM; Whitehouse, E | 1 |
| Capala, J; Coderre, JA; Makar, MS | 1 |
| Ichihashi, M; Kobayashi, T; Mizuma, N; Tano, K; Utsumi, H | 1 |
| Barth, RF; Goodman, JH; Joel, DD; Moeschberger, ML; Nawrocky, MM; Rotaru, JH; Soloway, AH; Yang, W | 1 |
| Carlsson, J; Gedda, L; Ghaneolhosseini, H; Hartman, T; Malmquist, J; Naeslund, C; Olsson, P; Sjöberg, S; Tjarks, W | 1 |
| Barth, RF; Goodman, JH; Joel, DD; Moeschberger, ML; Nawrocky, MM; Rotaru, JH; Yang, W | 1 |
| Bergland, R; Capala, J; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Joel, DD; Liu, HB; Slatkin, DN | 1 |
| Abe, M; Akaboshi, M; Akuta, K; Kinashi, Y; Kobayashi, T; Masunaga, S; Ono, K; Sakurai, Y; Suzuki, M; Takagaki, M | 1 |
| Buonocore, E; Dyke, JP; Hübner, KF; Kabalka, GW; Longford, CP; Reddy, NK; Reid, WS; Roberts, TG; Smith, GT | 1 |
| Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Gebbers, JO; Joel, DD; Micca, PL; Nawrocky, MM; Peress, NS; Shady, M; Slatkin, DN | 1 |
| Fujii, R; Ido, T; Imahori, Y; Kusuki, T; Ohmori, Y; Ono, K; Ueda, S | 1 |
| Akaboshi, M; Kinashi, Y; Kobayashi, T; Masunaga, S; Ono, K; Sakurai, Y; Suzuki, M; Takagaki, M | 3 |
| Bergland, RM; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Joel, DD | 1 |
| Capala, J; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Iwai, J; Joel, DD; Liu, HB; Wielopolski, L | 1 |
| Altieri, S; Barni, S; Fossati, F; Gerzeli, G; Nano, R; Pinelli, T; Prati, U; Roveda, L; Zonta, A | 1 |
| Fujii, R; Ido, T; Imahori, Y; Kobayashi, T; Kusuki, T; Ohmori, Y; Ono, K; Sakae, K; Takagaki, M; Ueda, S | 2 |
| Hiratsuka, J; Kondoh, H; Mishima, Y; Tsuboi, T | 1 |
| Coderre, JA; Hopewell, JW; Micca, PL; Morris, GM; Wielopolski, L | 1 |
| Barth, RF; Bartus, RT; Goodman, JH; Moeschberger, ML; Yang, W | 1 |
| Akaboshi, M; Kinashi, Y; Masunaga, S; Ono, K; Suzuki, M; Takagaki, M | 1 |
| Abe, Y; Akaizawa, T; Fukuda, H; Hiratsuka, J; Honda, C; Ichihashi, M; Kobayashi, T; Mishima, Y; Takahashi, J; Wadabayashi, N; Yoshino, K | 1 |
| Coderre, JA; Joel, DD; Micca, PL; Nawrocky, MM | 1 |
| Ye, SJ | 1 |
| Coderre, JA; Sauerwein, WA; Wittig, A | 1 |
| Devito, K; Gopalaswamy, R; Head, G; Sankar, S; Shull, BK; Spielvogel, DE | 1 |
| Aziz, T; Capala, J; Chanana, A; Diaz, A; Peress, NS | 1 |
| Barth, RF; Boesel, CP; Goodman, JH; Joel, DD; Moeschberger, ML; Nawrocky, MM; Ono, K; Rotaru, JH; Soloway, AH; Yang, W | 1 |
| Hiratsuka, J; Imajo, Y; Kondoh, H; Mishima, Y; Yoshino, K | 1 |
| Bendel, P; Kabalka, GW; Panov, V; Salomon, Y | 1 |
| Hiratsuka, J; Imajo, Y; Kondoh, H; Mishima, Y; Tsuboi, T; Yoshino, K | 1 |
| Barth, RF; Bartus, RT; Coderre, JA; Ferketich, AK; Goodman, JH; Moeschberger, ML; Nawrocky, MM; Rotaru, JH; Yang, W | 1 |
| Amorini, AM; Del Bolgia, F; Di Pierro, D; Fazzina, G; Giuffrè, R; Lazzarino, G; Pastore, FS; Tavazzi, B | 1 |
| Arguin, C; Charron, J; Hugo, P; Lesage, S; Trop, S | 1 |
| Aziz, T; Button, TM; Capala, J; Coderre, JA; Gavin, PR; Ma, R; Morris, GM; Peress, NS | 1 |
| Kondoh, H; Mishima, Y | 1 |
| Barth, RF; Boesel, CP; Bresnahan, JC; Goettl, VM; Hadjiconstantinou, M; Joel, DD; Nawrocky, MM; Rotaru, JH; Wilkie, DA; Yang, W | 1 |
| Coderre, JA; Hoch, DA; Kalef-Ezra, JA; Lombardo, DT; Ma, R; Micca, PL; Miura, M; Morris, GM; Slatkin, DN; Youngs, KM | 1 |
| Busse, PM; Kiger, WS; Palmer, MR; Riley, KJ; Zamenhof, RG | 1 |
| Cassapo, R; Castro, M; Chaveca, T; Fernandes, AP; Gonçalves, IC; Oliveira, NG; Rodrigues, AS; Rueff, J; Toscano-Rico, JM | 1 |
| Kinashi, Y; Kobayashi, T; Masunaga, S; Ono, K; Sakurai, Y; Suzuki, M; Takagaki, M | 1 |
| Barth, RF; Chandra, S; Coderre, JA; Joel, DD; Smith, DR; Yang, W | 1 |
| Blaumann, H; Calzetta, O; Itoiz, ME; Kreimann, EL; Longhino, J; Schwint, AE | 1 |
| Batistoni, D; Dagrosa, A; Farías, S; Garavaglia, R; Itoiz, ME; Kreimann, EL; Schwint, AE | 1 |
| Ehara, K; Hiratsuka, J; Iwakura, M; Kondoh, H; Mishima, Y; Tamaki, N | 1 |
| Agote, M; Cabrini, RL; Dadino, JL; Dagrosa, MA; Farías, S; Garavaglia, R; Juvenal, GJ; Kreimann, E; Pisarev, MA; Viaggi, M | 1 |
| Barth, RF; Bartus, RT; Coderre, JA; Ferketich, AK; Moeschberger, ML; Nawrocky, MM; Rofstad, EK; Rotaru, JH; Yang, W | 1 |
| Chandra, S; Coderre, JA; Kabalka, GW; Lorey, DR; Smith, DR | 1 |
| Kinashi, Y; Masunaga, S; Ono, K | 1 |
| Coderre, JA; Micca, PL; Morris, GM; Nawrocky, MM; Weissfloch, LE | 1 |
| Braun, I; Braun, K; Corban-Wilhelm, H; Debus, J; Ehemann, V; Eisenmenger, A; Heckl, S; Jenne, J; Pipkorn, R; Rastert, R; Waldeck, W; Wolber, G | 1 |
| Kato, I; Masunaga, S; Nagata, K; Obayashi, S; Ono, K; Sakurai, Y; Suzuki, M; Yura, Y | 1 |
| Al-Madhoun, AS; Barth, RF; Byun, Y; Chandra, S; Eriksson, S; Johnsamuel, J; Smith, DR; Tjarks, W; Yang, W | 1 |
| Fukuda, H; Furumoto, S; Matsumura, A; Nakamura, H; Takahashi, K; Yamamoto, K; Yamamoto, Y | 1 |
| Bergenheim, AT; Capala, J; Henriksson, R; Roslin, M | 1 |
| Filippov, VI; Komissarova, LKh; Kuznetsov, AA; Kuznetsov, OA; Podoynitsyn, SN | 1 |
| Basilico, F; Mauri, PL; Moss, R; Pozzi, F; Sauerwein, W; Wittig, A | 1 |
| Betti, M; Carlos, R; Cionini, L; de las Heras, LA; Lazzerini, G; Menichetti, L; Pitois, A; Salvatori, PA; Zampolli, A | 1 |
| Asano, T; Harada, T; Hiratsuka, J; Imajo, Y; Kondoh, H; Morita, N; Niki, Y; Ono, K; Sakurai, Y; Uno, M | 1 |
| Aihara, T; Harada, T; Hiratsuka, J; Maruhashi, A; Morita, N; Ono, K; Sakurai, Y; Uno, M | 1 |
| Halder, S; Kotha, S; Lahiri, K; Shah, VR; Vinodkumar, R | 1 |
| Ando, H; Asano, T; Hattori, Y; Kirihata, M; Kondoh, H; Wakamiya, T; Yamaguchi, Y; Yamamoto, H | 1 |
| Batistoni, DA; Gautier, EA; Gettar, RT; Jiménez Rebagliati, R; Roberti, MJ | 1 |
| Asano, T; Hattori, Y; Kirihata, M; Kondoh, H; Kurihara, K; Wakamiya, T; Yamaguchi, Y | 1 |
| Brun, A; H-Stenstam, B; Pellettieri, L; Rezaei, A; Sköld, K | 1 |
| Blaumann, H; Bumaschny, E; Calzetta, O; Cardoso, JE; Heber, EM; Itoiz, ME; Longhino, J; Nigg, DW; Pozzi, E; Schwint, AE; Trivillin, VA | 1 |
| Dagrosa, MA; Juvenal, GJ; Pisarev, MA | 1 |
| Blaumann, H; Cabrini, R; Calzetta, O; Dagrosa, MA; Juvenal, GJ; Kahl, S; Longhino, J; Perona, M; Pisarev, MA; Rebagliati, RJ; Thomasz, L | 1 |
| Bührmann, S; Collette, L; Huiskamp, R; Jöckel, KH; Kaiser, GM; Malago, M; Nievaart, V; Ortmann, U; Sauerwein, WA; Schmid, KW; Wittig, A | 1 |
| Barth, RF; Chandra, S; Lorey, DR; Tjarks, W | 1 |
| Fujita, Y; Iwai, S; Kamida, A; Kato, I; Ono, K; Sakurai, Y; Suzuki, M; Yura, Y | 1 |
| Nakamura, H | 1 |
| Brustad, E; Bushey, ML; Groff, D; Lee, JW; Liu, W; Schultz, PG | 1 |
| Albritton, JR; Auterinen, I; Binns, PJ; Harling, OK; Kiger, WS; Marek, M; Moss, RL; Nievaart, VA; Rezaei, A; Riley, KJ; Savolainen, S; Seppälä, T; Sköld, K; Viererbl, L | 1 |
| Cruickshank, GS; Detta, A | 1 |
| Collette, L; Moss, R; Sauerwein, WA; Wittig, A | 1 |
| Chi, CW; Chou, FI; Chung, HP; Liu, HM; Lui, WY | 1 |
| Bozzali, M; Cametti, C; Capuani, S; D'Amore, E; Gili, T; Lazzarino, G; Maraviglia, B; Muolo, M; Pastore, FS; Porcari, P; Russo, S | 1 |
| Blaumann, H; Calzetta Larrieu, OA; Casal, MR; Feld, DB; Fernández, C; González, SJ; Jiménez Rebagliati, R; Kessler, J; Liberman, SJ; Longhino, J; Menéndez, PR; Nievas, SI; Pereira, MD; Roth, BM; Santa Cruz, GA | 1 |
| Bumaschny, E; Cardoso, J; Heber, E; Itoiz, M; Liberman, S; Monti Hughes, A; Nievas, S; Pereira, M; Pozzi, E; Sanchez, P; Schwint, A; Trivillin, V | 1 |
| Kumada, H; Matsuda, M; Matsumura, A; Nakai, K; Shirakawa, M; Tsurubuchi, T; Yamamoto, T | 1 |
| Aromando, RF; Blaumann, H; Calzetta, O; Heber, EM; Itoiz, ME; Longhino, J; Monti Hughes, A; Nievas, SI; Nigg, DW; Pozzi, E; Schwint, AE; Trivillin, VA | 1 |
| Fujimoto, T; Fukumori, Y; Ichikawa, H; Taniguchi, E | 1 |
| Kumada, H; Matsumura, A; Nakai, K; Tsurubuchi, T; Yamamoto, T; Zaboronok, A | 1 |
| Altieri, S; Bortolussi, S; Bruschi, P; Clerici, AM; Dionigi, P; Ferrari, C; Fossati, F; Mazzini, G; Pinelli, T; Prati, U; Roveda, L; Zonta, A; Zonta, C | 1 |
| Altieri, S; Bortolussi, S; Bruschi, P; Cansolino, L; Clerici, AM; Dionigi, P; Ferrari, C; Gaspari, A; Stella, S; Zonta, A; Zonta, C | 1 |
| Altieri, S; Bakeine, GJ; Bertolotti, A; Bortolussi, S; Bruschi, P; Clerici, A; Di Salvo, M; Ferrari, C; Marchetti, A; Nano, R; Stella, S; Zonta, C | 1 |
| Ariyoshi, Y; Kawabata, S; Kimura, Y; Maruhashi, A; Miyatake, S; Ono, K; Shimahara, M; Suzuki, M | 1 |
| Doi, A; Hiramatsu, R; Iida, K; Imahori, Y; Kawabata, S; Kirihata, M; Kumada, H; Kuroda, Y; Kuroiwa, T; Maruhashi, A; Masunaga, S; Michiue, H; Miyata, S; Miyatake, S; Nonoguchi, N; Ono, K; Sakurai, Y; Suzuki, M; Yokoyama, K | 1 |
| Anno, I; Isobe, T; Matsumura, A; Matsushita, A; Nakai, K; Sato, E; Shibata, Y; Shirakawa, M; Yamamoto, T; Yamamoto, Y | 1 |
| Arnopolskaya, AM; Khokhlov, VF; Kozlovskaya, NG; Kulakov, VN; Mitin, VN; Portnov, AA; Sheino, IN; Zaitsev, KN | 1 |
| Aburai, K; Kawatobi, S; Matsumura, A; Nakai, K; Okuno, H; Shirakawa, M; Tsurubuchi, T; Yamamoto, Y; Yamamto, T; Yokoyama, Y | 1 |
| Boddy, A; Braithwaite, R; Chester, M; Chopra, A; Croswell, G; Cruickshank, GS; Detta, A; Doran, J; Elliot, M; Ford, S; Ghani, Z; Graham, N; Green, S; Halbert, G; Hardie, J; James, ND; Lockyer, N; Ngoga, D; Sheehan, TM; Steinfeldt, H; Sugar, R; Vickerman, J; Wojnecki, C | 1 |
| Barth, RF | 2 |
| Barth, RF; Binns, P; Riley, K; Tjarks, W; Wu, G; Yang, W | 1 |
| Fujii, N; Fukutani, S; Kashino, G; Kinashi, Y; Liu, Y; Maruhashi, A; Masunaga, S; Nagata, K; Ono, K; Sakurai, Y; Suzuki, M; Tanaka, H | 1 |
| Brustad, EM; Groff, D; Liu, CC; Mack, AV; Mills, JH; Schultz, PG; Smider, VV | 1 |
| Appelman, K; Bührmann, S; Collette, L; Jäckel, MC; Jöckel, KH; Moss, R; Ortmann, U; Sauerwein, WAG; Schmid, KW; Wittig, A | 1 |
| Basilico, F; Bendel, P; Mauri, PL; Sauerwein, W; Wittig, A | 1 |
| Bet, P; Hilken, G; Huiskamp, R; Kriegeskotte, C; Moss, RL; Sauerwein, WA; Scherag, A; Wittig, A | 1 |
| Guo, J; Robbins, S; Schultz, PG; Shen, W; Wang, F | 1 |
| Aromando, RF; Heber, EM; Itoiz, ME; Pozzi, E; Schwint, AE; Trivillin, VA | 1 |
| Cabrini, R; Casal, M; Crivello, M; Dagrosa, MA; Juvenal, GJ; Kahl, S; Perona, M; Pisarev, MA; Pozzi, E; Santa Cruz, GA; Thomasz, L; Thorp, S | 1 |
| Cheng, X; Guo, G; Jiang, X; Mao, X; Wang, P; Zhang, W; Zhang, X; Zhen, H | 1 |
| Fujita, Y; Iwai, S; Kato, I; Ohnishi, K; Ohnishi, T; Ono, K; Sakurai, Y; Yamamoto, N; Yura, Y | 1 |
| Akisue, T; Andoh, T; Epstein, AL; Fujimoto, T; Fujita, I; Fukumori, Y; Ichikawa, H; Imabori, M; Kirihata, M; Kurosaka, M; Moritake, H; Sakuma, Y; Sonobe, H; Sudo, T; Sugimoto, T; Takeuchi, T | 1 |
| Akisue, T; Andoh, T; Fujimoto, T; Fujita, I; Fukumori, Y; Ichikawa, H; Imabori, M; Kawabata, S; Kirihata, M; Kurosaka, M; Miyatake, S; Moritake, H; Sakuma, Y; Sudo, T; Sugimoto, T; Takeuchi, T; Yayama, K | 1 |
| Brualla, L; Collette, L; Moss, R; Sauerwein, W; Sheu-Grabellus, SY; Wittig, A | 1 |
| Chou, FI; Chung, HP; Lin, YC; Liu, HM; Wang, SJ | 1 |
| Cabrini, R; Carpano, M; Dagrosa, A; Juvenal, G; Nievas, S; Perona, M; Pisarev, M; Thomasz, L | 1 |
| García-Reiriz, A; Líberman, S; Magallanes, J; Zupan, J | 1 |
| Aromando, RF; Garabalino, MA; Heber, EM; Itoiz, ME; Miller, M; Molinari, AJ; Monti Hughes, A; Nigg, DW; Pozzi, EC; Schwint, AE; Thorp, S; Trivillin, VA | 1 |
| Aromando, RF; Garabalino, MA; Heber, EM; Itoiz, ME; Miller, M; Molinari, AJ; Monti Hughes, A; Nigg, DW; Pozzi, EC; Schwint, AE; Thorp, SI; Trivillin, VA | 1 |
| Chang, CW; Chou, FI; Hsiao, MC; Hwang, JJ; Lin, YC; Wang, SJ; Yang, BH | 1 |
| Chen, YW; Kashino, G; Kirihata, M; Liu, Y; Masunaga, S; Ono, K; Sakurai, Y; Suzuki, M; Tanaka, H | 1 |
| Fujiwara, K; Kinashi, Y; Kurihara, K; Ono, K; Sakurai, Y; Takahashi, S; Takahashi, T; Tanaka, H; Yashima, H | 1 |
| Arai, Y; Fujii, H; Honda, N; Itami, J; Kawai, K; Kurihara, H; Ohe, K; Yoshimoto, M | 1 |
| Carpano, M; Curotto, P; Dagrosa, A; Juvenal, G; Kahl, S; Nievas, S; Olivera, M; Perona, M; Pisarev, M; Pozzi, E; Rodríguez, C; Thomasz, L; Thorp, S | 1 |
| Iwagami, T; Iwai, S; Kato, I; Masunaga, S; Nakazawa, M; Ono, K; Sakurai, Y; Yamatomo, N; Yura, Y | 1 |
| Moss, RL; Sauerwein, WA; Wittig, A | 1 |
| Bauer, W; Garabalino, MA; Heber, EM; Molinari, AJ; Monti Hughes, A; Nigg, DW; Pozzi, EC; Schwint, AE; Trivillin, VA | 1 |
| Altieri, S; Aromando, RF; Bortolussi, S; Colombo, LL; Farías, RO; Garabalino, MA; González, SJ; Itoiz, ME; Monti Hughes, A; Nigg, DW; Pozzi, EC; Schwint, AE; Trivillin, VA | 1 |
| Kinashi, Y; Kitajima, E; Kubota, Y; Okayasu, R; Okumura, K; Ono, K; Takahashi, S | 1 |
| Isobe, T; Matsumura, A; Nakai, K; Ogura, M; Sato, E; Shikano, N; Takada, T; Uemae, Y; Yamamoto, T; Yoshida, F | 1 |
| Andoh, T; Epstein, AL; Fujimoto, T; Fukumori, Y; Ichikawa, H; Moritake, H; Ono, K; Sakuma, T; Sakurai, Y; Sonobe, H; Sudo, T; Sugimoto, T; Suzuki, M; Takeuchi, T | 1 |
| Barth, RF; Chandra, S; Haider, SA; Huo, T; Kabalka, GW; Shaikh, AL; Yang, W | 1 |
| Chang, CW; Chang, WY; Chen, JC; Li, JJ; Wang, HE; Yang, FY | 1 |
| Hattori, T; Ishikawa, A; Ohki, H; Saito, K; Yabe, T; Yoshino, K | 1 |
| Ahmad, T; Barth, RF; Chandra, S; Kabalka, GW | 1 |
| Chen, G; Du, Z; Li, B; Li, Y; Sun, T; Wei, Y; Wu, T; Xie, X; Zhou, Y | 1 |
| Casal, M; Dagrosa, MA; Juvenal, GJ; Navarro, A; Pisarev, MA; Portu, A; Rossini, AE; Saint Martin, G; Thorp, S | 1 |
| Bernocchi, G; Coccini, T; Nion, S; Roda, E | 1 |
| Canella, L; Kudejova, P; Röhrmoser, A; Schmid, E; Schmid, TE; Wagner, FM | 1 |
| Hagiwara, K; Hamase, K; Kanai, Y; Kato, I; Miyoshi, Y; Nagamori, S; Ohgaki, R; Wei, L; Wiriyasermkul, P; Wongthai, P | 1 |
| Hattori, Y; Ishimura, M; Kirihata, M; Ohta, Y; Ono, K; Takenaka, H; Tanaka, H; Watanabe, T | 1 |
| Matsumura, A; Nakai, K; Yamamoto, T; Yoshida, F; Zaboronok, A | 1 |
| Ai, HW; Borchardt, D; Chen, ZJ; Ji, A; Jiang, DE; Kallio, K; Oleson, AL; Remington, SJ; Tian, Z | 1 |
| Kreis, K; Kuntner, C; Langer, O; Mairinger, S; Muchitsch, V; Stanek, J; Wanek, T; Wingelhofer, B | 1 |
| Blaickner, M; Filip, T; Grunewald, C; Kudejova, P; Kuntner, C; Langer, O; Mairinger, S; Rollet, S; Sauberer, M; Schütz, C; Stanek, J; Wanek, T | 1 |
| Guo, J; Niu, W | 1 |
| Anbai, A; Harada, T; Hashimoto, M; Hirose, K; Sato, M; Takai, Y; Wada, Y; Watanabe, T | 1 |
| Anzai, N; Harada, S; Jutabha, P; Kajihara, R; Muramoto, R; Nemoto, T | 1 |
| Landgraf, M; Nästle, L; Reichert, AJ; Schiefner, A; Skerra, A | 1 |
| Chatterjee, A; Italia, JS; Latour, C; Wrobel, CJJ | 1 |
| Inohara, H; Jin, C; Kanai, Y; Liu, X; Miyabe, J; Nagamori, S; Ohgaki, R; Ohki, H; Okuda, S; Quan, L; Saito, K; Wei, L; Yoshino, K | 1 |
| Hattori, Y; Hermawan, A; Ishimura, M; Kirihata, M; Meiyanto, E; Ohta, Y; Qodria, L; Ramadani, RD; Susidarti, RA; Utomo, RY | 1 |
| Beckford-Vera, DR; Blaha, C; Blecha, JE; Evans, MJ; Flavell, RR; Fogarty, M; Hayes, TR; Hong, AS; Hope, TA; Huynh, T; Ozawa, T; Raleigh, DR; Santos, R; VanBrocklin, HF; Wang, S; Wilson, DM | 1 |
| Eichinger, A; Skerra, A; Sommer, CA | 1 |
| Abe, Y; Fujii, R; Igaki, H; Imahori, Y; Itami, J; Kurihara, H; Morita, T; Nakamura, M; Nakamura, S; Nakayama, Y; Nishioka, S; Okamoto, H | 1 |
| Inoue, Y; Kanamori, K; Matsui, M; Nishiyama, N; Nomoto, T; Suzuki, M; Takemoto, H; Tomoda, K; Yao, Y | 2 |
| Date, H; Fukunaga, H; Matsuya, Y; Omura, M | 1 |
| Fukuda, H; Hiratsuka, J | 1 |
| Jevremovic, T; Moffitt, G; Stewart, RD; Streitmatter, SW | 1 |
| Fukuda, H | 1 |
| Suzuki, M; Takata, T; Takeno, S; Tamari, Y; Tanaka, H; Yamada, K; Yamazaki, H | 1 |
| Ai, HW; Fan, Y; Huang, M; Ng, HL; Pang, Y; Xiong, Y; Yeh, HW | 1 |
8 review(s) available for phenylalanine and 4-boronophenylalanine
| Article | Year |
|---|---|
A post melanosomal era: control of melanogenesis and melanoma growth.
Topics: Adolescent; Animals; Boron; Boron Compounds; Cricetinae; Fatty Acids, Unsaturated; Gene Expression Regulation, Neoplastic; Hair Color; Humans; Infant, Newborn; Isotopes; Male; Melanins; Melanocytes; Melanoma; Melanoma, Experimental; Models, Biological; Monophenol Monooxygenase; Neoplasm Proteins; Neutrons; Phenylalanine; Pigmentation Disorders; Protein Processing, Post-Translational; Pyrones; Radiation-Sensitizing Agents; Skin Pigmentation; Subcellular Fractions; Swine | 1992 |
[Neutron capturing irradiation: principle, current results and perspectives].
Topics: Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cell Survival; Drug Carriers; Humans; Linear Energy Transfer; Neoplasms; Nuclear Reactors; Particle Accelerators; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Sulfhydryl Compounds | 1995 |
Chemistry and biology of some low molecular weight boron compounds for boron neutron capture therapy.
Topics: Amino Acids; Boron Compounds; Boron Neutron Capture Therapy; DNA; Humans; Intercalating Agents; Molecular Structure; Neoplasms; Phenylalanine; Structure-Activity Relationship | 1997 |
Boron neutron capture therapy in cancer: past, present and future.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Deuteroporphyrins; Disease Models, Animal; Dogs; Humans; Mice; Mice, Nude; Phenylalanine; Radiation-Sensitizing Agents; Thyroid Neoplasms | 2007 |
[Boron delivery system for neutron capture therapy of cancer].
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Drug Delivery Systems; Humans; Liposomes; Neoplasms; Phenylalanine; Positron-Emission Tomography | 2008 |
Boron neutron capture therapy at the crossroads: challenges and opportunities.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Fast Neutrons; Glioma; Humans; Nuclear Reactors; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Planning, Computer-Assisted; Randomized Controlled Trials as Topic; Rats; Sulfhydryl Compounds | 2009 |
Pharmacokinetics of
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioblastoma; Humans; Isotopes; Melanoma; Neoplasms; Phenylalanine; Positron-Emission Tomography | 2020 |
Boron Neutron Capture Therapy (BNCT) for Cutaneous Malignant Melanoma Using
Topics: Boron Compounds; Boron Neutron Capture Therapy; Clinical Trials as Topic; Humans; Melanoma; Melanoma, Cutaneous Malignant; Phenylalanine; Radiobiology; Relative Biological Effectiveness; Skin Neoplasms | 2021 |
12 trial(s) available for phenylalanine and 4-boronophenylalanine
| Article | Year |
|---|---|
Boron neutron capture therapy of malignant melanoma using 10B-paraboronophenylalanine with special reference to evaluation of radiation dose and damage to the normal skin.
Topics: Aged; Boron Compounds; Boron Neutron Capture Therapy; Female; Humans; Male; Melanoma; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Skin; Skin Neoplasms | 1994 |
Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results.
Topics: Adult; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Glioblastoma; Humans; Magnetic Resonance Imaging; Neutrons; Nuclear Reactors; Phenylalanine; Tissue Distribution | 1997 |
Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory.
Topics: Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Dose-Response Relationship, Radiation; Feasibility Studies; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Treatment Outcome | 1998 |
A pharmacokinetic model for the concentration of 10B in blood after boronophenylalanine-fructose administration in humans.
Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Female; Fructose; Glioblastoma; Humans; Infusions, Intravenous; Male; Melanoma; Middle Aged; Models, Biological; Phenylalanine; Skin Neoplasms | 2001 |
Neuropathological postmortem evaluation of BNCT for GBM.
Topics: Aged; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Follow-Up Studies; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiotherapy Dosage; Treatment Outcome | 2007 |
Uptake of two 10B-compounds in liver metastases of colorectal adenocarcinoma for extracorporeal irradiation with boron neutron capture therapy (EORTC Trial 11001).
Topics: Adenocarcinoma; Adult; Aged; Boron Compounds; Boron Neutron Capture Therapy; Colorectal Neoplasms; Female; Humans; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Phenylalanine; Transplantation, Autologous | 2008 |
Early clinical trial concept for boron neutron capture therapy: a critical assessment of the EORTC trial 11001.
Topics: Adenocarcinoma; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Colorectal Neoplasms; Female; Head and Neck Neoplasms; Humans; Liver Neoplasms; Male; Neoplasms; Phenylalanine; Prospective Studies; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Thyroid Neoplasms; Tissue Distribution | 2009 |
BNCT for skin melanoma in extremities: updated Argentine clinical results.
Topics: Aged; Argentina; Boron Compounds; Boron Neutron Capture Therapy; Female; Humans; Leg; Male; Melanoma; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Skin Neoplasms | 2009 |
Boron biodistribution study in colorectal liver metastases patients in Argentina.
Topics: Adenocarcinoma; Aged; Argentina; Boron; Boron Compounds; Boron Neutron Capture Therapy; Colorectal Neoplasms; Female; Humans; In Vitro Techniques; Infusions, Intravenous; Isotopes; Liver; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution; Transplantation, Autologous | 2009 |
A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT.
Topics: Aged; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioma; Humans; Male; Mannitol; Phenylalanine; Radiation-Sensitizing Agents; United Kingdom | 2009 |
EORTC trial 11001: distribution of two 10B-compounds in patients with squamous cell carcinoma of head and neck, a translational research/phase 1 trial.
Topics: Adult; Aged; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Male; Middle Aged; Phenylalanine; Sulfhydryl Compounds; Tissue Distribution | 2009 |
BPA uptake does not correlate with LAT1 and Ki67 expressions in tumor samples (results of EORTC trial 11001).
Topics: Boron Compounds; Humans; Immunohistochemistry; Ki-67 Antigen; Large Neutral Amino Acid-Transporter 1; Phenylalanine; Spectrometry, Gamma | 2011 |
184 other study(ies) available for phenylalanine and 4-boronophenylalanine
| Article | Year |
|---|---|
In vitro radiobiological analysis of 10B-L-BPA for BNCT of malignant melanoma: correlation of determined 10B-content and cell killing effect.
Topics: Animals; Boron; Boron Compounds; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Isotopes; Mass Spectrometry; Melanoma, Experimental; Mice; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1992 |
A unique in vivo assessment of 4-[10B]borono-L-phenylalanine in tumour tissues for boron neutron capture therapy of malignant melanomas using positron emission tomography and 4-borono-2-[18F]fluoro-L-phenylalanine.
Topics: Animals; Boron Compounds; Cricetinae; Fluorine Radioisotopes; Melanoma, Experimental; Mesocricetus; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neutron Capture Therapy; Phenylalanine; Tissue Distribution; Tomography, Emission-Computed | 1992 |
Local control of subcutaneous murine melanoma xenografts in nude mice by neutron capture therapy.
Topics: Animals; Boron Compounds; Cell Division; Cell Line; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Neutron Capture Therapy; Phenylalanine; Radiation-Sensitizing Agents; Skin; Skin Neoplasms | 1992 |
Intracellular boron localization and uptake in cell cultures using imaging secondary ion mass spectrometry (ion microscopy) for neutron capture therapy for cancer.
Topics: Animals; Boron Compounds; Cryopreservation; Mass Spectrometry; Mice; Microscopy; Neoplasms; Neutrons; Phenylalanine; Tumor Cells, Cultured; Uridine | 1992 |
Boron neutron capture therapy for murine malignant gliomas.
Topics: Animals; Boron Compounds; Brain; Brain Neoplasms; Glioma; Mice; Mice, Inbred C57BL; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Survival Analysis | 1992 |
Control of intracerebral gliosarcomas in rats by boron neutron capture therapy with p-boronophenylalanine.
Topics: Animals; Boron Compounds; Brain Neoplasms; Glioma; Male; Neoplasm Transplantation; Neutrons; Phenylalanine; Rats; Rats, Inbred F344 | 1992 |
Tissue distribution of para-boronophenylalanine administered orally as a cyclodextrin inclusion complex to melanoma-bearing hamsters.
Topics: Administration, Oral; Animals; Boron Compounds; Cricetinae; Cyclodextrins; Male; Melanoma, Experimental; Mesocricetus; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Skin Neoplasms; Tissue Distribution | 1992 |
Boron neutron capture therapy of anterior chamber melanoma with p-boronophenylalanine.
Topics: Administration, Oral; Animals; Anterior Chamber; Autoradiography; Boron; Boron Compounds; Disease Models, Animal; Eye Neoplasms; Isotopes; Melanoma, Experimental; Neutrons; Phenylalanine; Rabbits; Radiation-Sensitizing Agents | 1992 |
Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D,L-phenylalanine: a target compound for PET and boron neutron capture therapy.
Topics: Animals; Boron Compounds; Fluorine Radioisotopes; Isotope Labeling; Male; Mice; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Tissue Distribution; Tomography, Emission-Computed | 1991 |
Boron neutron capture therapy of a murine melanoma with p-boronophenylalanine: dose-response analysis using a morbidity index.
Topics: Animals; Boron Compounds; Dose-Response Relationship, Radiation; Melanoma, Experimental; Mice; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; X-Ray Therapy | 1991 |
The relative biological effectiveness of 10B-neutron capture therapy for early skin reaction in the hamster.
Topics: Animals; Boron Compounds; Cricetinae; Dose-Response Relationship, Radiation; Male; Mesocricetus; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Relative Biological Effectiveness; Skin | 1991 |
In situ detection of cutaneous melanoma by prompt gamma-ray spectrometry using melanoma-seeking 10B-dopa analogue.
Topics: Aged; Animals; Boron; Boron Compounds; Cricetinae; Disease Models, Animal; Female; Humans; Isotopes; Male; Melanoma; Mesocricetus; Phenylalanine; Skin Neoplasms; Spectrometry, Gamma; Time Factors | 1990 |
Experimental boron neutron capture therapy for melanoma: systemic delivery of boron to melanotic and amelanotic melanoma.
Topics: Animals; Boron; Boron Compounds; Eye Neoplasms; Isotopes; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neutrons; Phenylalanine; Rabbits; Radiation-Sensitizing Agents; Transplantation, Heterologous | 1990 |
Boron neutron capture therapy for cancer.
Topics: Alpha Particles; Animals; Antibodies, Monoclonal; Boron; Boron Compounds; Brain Neoplasms; Glioblastoma; Humans; Immunotoxins; Isotopes; Melanoma; Mice; Neoplasms; Neutrons; Phenylalanine; Radiation Dosage | 1990 |
Selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma.
Topics: Animals; Boron Compounds; Brain Neoplasms; Cell Line; Drug Carriers; Glioma; Humans; Isotopes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neutrons; Phenylalanine; Rats; Tissue Distribution; Transplantation, Heterologous | 1990 |
[RBEs of thermal neutron capture therapy and 10B(n, alpha)7Li reaction on melanoma bearing hamster].
Topics: Animals; Boron Compounds; Cricetinae; Isotopes; Lithium; Melanoma, Experimental; Mesocricetus; Neutrons; Phenylalanine; Relative Biological Effectiveness | 1988 |
Selective targeting of boronophenylalanine to melanoma in BALB/c mice for neutron capture therapy.
Topics: Animals; Boron Compounds; Mammary Neoplasms, Experimental; Melanins; Melanoma; Mice; Mice, Inbred BALB C; Neutrons; Phenylalanine; Stereoisomerism; Tissue Distribution | 1987 |
[Selective affinity of 10B1-paraboronophenylalanine-HCl to malignant melanoma: thermal neutron capture therapy].
Topics: Animals; Boron; Boron Compounds; Cricetinae; Isotopes; Melanoma; Neoplasms, Experimental; Neutrons; Phenylalanine; Skin; Skin Neoplasms; Spectrometry, Gamma | 1983 |
Specific killing effect of 10B1-para-boronophenylalanine in thermal neutron capture therapy of malignant melanoma: in vitro radiobiological evaluation.
Topics: Boron Compounds; Cell Survival; Cells, Cultured; Culture Media; Humans; In Vitro Techniques; Melanoma; Neutrons; Phenylalanine; Premedication; Radiation-Sensitizing Agents; Skin Neoplasms | 1982 |
Synthesis and biological properties of water-soluble p-boronophenylalanine derivatives. Relationship between water solubility, cytotoxicity, and cellular uptake.
Topics: Antineoplastic Agents; Boron Compounds; Cell Line; Drug Screening Assays, Antitumor; Humans; Phenylalanine; Tumor Cells, Cultured; Water | 1995 |
Response of the central nervous system to boron neutron capture irradiation: evaluation using rat spinal cord model.
Topics: Absorption; Animals; Blood-Brain Barrier; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; Dose-Response Relationship, Radiation; Isotopes; Linear Energy Transfer; Male; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Rats, Inbred F344; Relative Biological Effectiveness; Spinal Cord; Spinal Cord Diseases; Sulfhydryl Compounds | 1994 |
Effect of L-10B-p-boronophenylalanine-fructose and the boron neutron capture reaction on mouse brain dopaminergic neurons.
Topics: Animals; Blood-Brain Barrier; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Dopamine; Fructose; Immunohistochemistry; Isotopes; Male; Mice; Mice, Inbred BALB C; Nerve Fibers; Neurons; Phenylalanine; Radiation-Sensitizing Agents | 1995 |
Selective boron accumulation in human ocular melanoma vs surrounding eye components after 10B1-p-boronophenylalanine administration. Prerequisite for clinical trial of neutron-capture therapy.
Topics: Boron; Boron Compounds; Clinical Trials as Topic; Eye Neoplasms; Humans; Isotopes; Mass Spectrometry; Melanoma; Neutron Capture Therapy; Phenylalanine; Radiation-Sensitizing Agents | 1994 |
Subcellular localization of p-boronophenylalanine-delivered boron-10 in the rat 9L gliosarcoma: cryogenic preparation in vitro and in vivo.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Gliosarcoma; Isotopes; Phenylalanine; Rats; Tumor Cells, Cultured | 1994 |
Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium.
Topics: Administration, Oral; Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Dose-Response Relationship, Radiation; Endothelium, Vascular; Injections, Intravenous; Isotopes; Male; Phenylalanine; Radiation Dosage; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Relative Biological Effectiveness; Skin; Skin Diseases; Spectrometry, Gamma; Sulfhydryl Compounds; Wound Healing | 1994 |
Preloading with L-tyrosine increases the uptake of boronophenylalanine in mouse melanoma cells.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Melanoma; Mice; Phenylalanine; Radiation-Sensitizing Agents; Time Factors; Tumor Cells, Cultured; Tyrosine | 1994 |
Cancer treatment. Will history repeat for boron capture therapy?
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Clinical Trials as Topic; Glioblastoma; Humans; Japan; Phenylalanine; Radiation-Sensitizing Agents; United States | 1994 |
[Neutron capture therapy for cancer].
Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Humans; Infusions, Intravenous; Melanoma; Phenylalanine; Skin Neoplasms | 1994 |
A nude rat model for neutron capture therapy of human intracerebral melanoma.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Female; Humans; Male; Melanoma; Mice; Middle Aged; Neoplasm Transplantation; Phenylalanine; Rats; Rats, Nude; Tumor Cells, Cultured | 1994 |
Radiation effects of boron neutron capture therapy on brain, skin, and eye of rats.
Topics: Animals; Body Weight; Boron Compounds; Boron Neutron Capture Therapy; Brain; Eye; Female; Phenylalanine; Rats; Rats, Nude; Skin | 1994 |
The pharmacokinetics of p-Boronophenylalanine.fructose in human patients with glioma and metastatic melanoma.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioma; Humans; Melanoma; Phenylalanine; Radiation-Sensitizing Agents | 1994 |
Improved bioavailability of para-boronophenylalanine by cyclodextrin complexation.
Topics: Animals; Biological Availability; Boron Compounds; Chromatography, High Pressure Liquid; Cyclodextrins; Drug Design; Male; Phenylalanine; Powders; Rats; Rats, Wistar; Solubility; Spectrophotometry, Infrared; X-Ray Diffraction | 1993 |
Neutron capture therapy of a rat glioma using boronophenylalanine as a capture agent.
Topics: Animals; Boron Compounds; Brain; Cell Survival; Dose-Response Relationship, Radiation; Glioma; Male; Neutron Capture Therapy; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Survival Analysis; Time Factors; Tissue Distribution; Tumor Cells, Cultured; X-Rays | 1994 |
Penetration and binding of L- and D-carboranylalanine in human melanoma spheroids.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Cell Aggregation; Cell Cycle; Humans; Melanoma; Phenylalanine; Radiation-Sensitizing Agents; Stereoisomerism; Thymidine; Tritium; Tumor Cells, Cultured | 1993 |
Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Cell Survival; Humans; Male; Melanoma; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Rats, Nude; Tissue Distribution | 1993 |
Selectivity of boron carriers for boron neutron capture therapy: pharmacological studies with borocaptate sodium, L-boronophenylalanine and boric acid in murine tumors.
Topics: Animals; Boric Acids; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Injections, Intraperitoneal; Kidney; Liver; Male; Melanoma; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Phenylalanine; Radiation-Sensitizing Agents; Sarcoma, Experimental; Sulfhydryl Compounds; Time Factors | 1993 |
Intracellular distribution of various boron compounds for use in boron neutron capture therapy.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cell Survival; Isotopes; Phenylalanine; Radiochemistry; Spectrophotometry, Atomic; Subcellular Fractions; Sulfhydryl Compounds; Sulfides; Tumor Cells, Cultured | 1993 |
Maximum therapeutic depth in thermal neutron capture therapy.
Topics: Boranes; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Humans; Neoplasms; Phenylalanine; Sulfhydryl Compounds | 1993 |
Cellular accumulation of 18F-labelled boronophenylalanine depending on DNA synthesis and melanin incorporation: a double-tracer microautoradiographic study of B16 melanomas in vivo.
Topics: Animals; Autoradiography; Boron Compounds; Boron Neutron Capture Therapy; Cell Division; Disease Models, Animal; DNA, Neoplasm; Fluorine Radioisotopes; Male; Melanins; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasm Transplantation; Phenylalanine; Pigmentation; Radionuclide Imaging | 1993 |
Hydroxylforms of p-boronophenylalanine as potential boron carriers on boron neutron capture therapy for malignant brain tumors.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Survival; Glioma; Humans; Hydroxylation; Male; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344 | 1996 |
Enhanced delivery of boronophenylalanine for neutron capture therapy by means of intracarotid injection and blood-brain barrier disruption.
Topics: Animals; Blood-Brain Barrier; Boron Compounds; Brain; Brain Neoplasms; Carotid Arteries; Dominance, Cerebral; Glioma; Injections, Intra-Arterial; Mannitol; Neoplasm Transplantation; Neutron Capture Therapy; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Cells, Cultured | 1996 |
Boron neutron capture irradiation of the rat spinal cord: histopathological evidence of a vascular-mediated pathogenesis.
Topics: Alpha Particles; Animals; Blood Vessels; Bone Neoplasms; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Fibrosarcoma; Gamma Rays; Male; Neoplasms, Radiation-Induced; Neutrons; Phenylalanine; Photons; Protons; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Spinal Cord; Spinal Cord Neoplasms; Sulfhydryl Compounds; X-Rays | 1996 |
Accumulation of boron in malignant and normal cells incubated in vitro with boronophenylalanine, mercaptoborane or boric acid.
Topics: Animals; Boric Acids; Boron; Boron Compounds; Boron Neutron Capture Therapy; Humans; Mice; Phenylalanine; Tumor Cells, Cultured | 1996 |
Cellular effect of thermal neutron capture treatment using 10B1-para-boronophenylalanine: lethal effect on melanoma cells with different degrees of X-ray sensitivity.
Topics: Antibiotics, Antineoplastic; Bleomycin; Boron Compounds; Boron Neutron Capture Therapy; Humans; Melanoma; Phenylalanine; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1996 |
Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption.
Topics: Alpha Particles; Animals; Blood-Brain Barrier; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Carotid Arteries; Glioma; Injections, Intra-Arterial; Mannitol; Phenylalanine; Rats; Rats, Inbred F344; Sulfhydryl Compounds | 1997 |
Enhanced survival of glioma bearing rats following boron neutron capture therapy with blood-brain barrier disruption and intracarotid injection of boronophenylalanine.
Topics: Animals; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Carotid Arteries; Fructose; Glioma; Humans; Infusions, Intra-Arterial; Injections, Intra-Arterial; Male; Mannitol; Phenylalanine; Rats; Rats, Inbred F344; Survival Rate; Tissue Distribution | 1997 |
Modification of the response of a quiescent cell population within a murine solid tumour to boron neutron capture irradiation: studies with nicotinamide and hyperthermia.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Hyperthermia, Induced; Mice; Mice, Inbred C3H; Micronucleus Tests; Neoplasm Transplantation; Niacinamide; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1997 |
Evaluation of fluorine-18-BPA-fructose for boron neutron capture treatment planning.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Female; Fluorine Radioisotopes; Fructose; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Tomography, Emission-Computed | 1997 |
Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: boron concentration correlates with tumor cellularity.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Glioblastoma; Humans; Phenylalanine; Tissue Distribution | 1998 |
Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma.
Topics: Astrocytoma; Boron Compounds; Brain Neoplasms; Cerebrovascular Circulation; Fluorine Radioisotopes; Glioblastoma; Glioma; Humans; Phenylalanine; Radiopharmaceuticals; Tomography, Emission-Computed | 1998 |
Responses of total and quiescent cell populations in solid tumors to boron and gadolinium neutron capture reaction using neutrons with two different energy spectra.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Bromodeoxyuridine; Cadmium Radioisotopes; Carcinoma, Squamous Cell; Contrast Media; Cytochalasin B; Dose-Response Relationship, Radiation; Female; Fluorescent Antibody Technique, Indirect; Gadolinium; Gadolinium DTPA; Injections, Intraperitoneal; Isotopes; Mice; Mice, Inbred C3H; Micronucleus Tests; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tumor Cells, Cultured | 1998 |
Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy.
Topics: Boron Compounds; Brain; Brain Neoplasms; Craniotomy; Glioblastoma; Humans; Injections, Intravenous; Neutron Capture Therapy; Osmolar Concentration; Phenylalanine; Radiation-Sensitizing Agents; Scalp; Tissue Distribution | 1998 |
Histiocytic activation following neutron irradiation of boron-enriched rat liver metastases.
Topics: Alpha Particles; Animals; Boron Compounds; Colonic Neoplasms; Kupffer Cells; Liver; Liver Neoplasms; Macrophage Activation; Neutrons; Phagocytosis; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains | 1997 |
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part I.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Fluorine Radioisotopes; Glioma; Humans; Isotopes; Phenylalanine; Radiation-Sensitizing Agents; Tomography, Emission-Computed | 1998 |
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part II.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Fluorine Radioisotopes; Glioma; Humans; Isotopes; Mathematical Computing; Phenylalanine; Radiation-Sensitizing Agents; Tomography, Emission-Computed | 1998 |
Response of quiescent and total tumor cells in solid tumors to neutrons with various cadmium ratios.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Bromodeoxyuridine; Cadmium Radioisotopes; Carcinoma, Squamous Cell; Cell Division; Dose-Response Relationship, Radiation; Energy Transfer; Female; Gamma Rays; Mice; Mice, Inbred C3H; Micronucleus Tests; Phenylalanine; Relative Biological Effectiveness; Sulfhydryl Compounds | 1998 |
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cells, Cultured; Gene Expression; Gene Transfer Techniques; Indolequinones; Indoles; Kinetics; Melanins; Melanoma, Amelanotic; Mice; Monophenol Monooxygenase; Phenylalanine; Quinones; Reverse Transcriptase Polymerase Chain Reaction | 1998 |
Boron neutron capture therapy: re-irradiation response of the rat spinal cord.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Male; Paralysis; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy, High-Energy; Rats; Rats, Inbred F344; Retreatment; Spinal Cord | 1998 |
Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analog Cereport (Receptor-Mediated Permeabilizer-7).
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Bradykinin; Brain Neoplasms; Carotid Arteries; Dose-Response Relationship, Drug; Glioma; Injections, Intra-Arterial; Injections, Intravenous; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tissue Distribution | 1999 |
The combined effect of boronophenylalanine and borocaptate in boron neutron capture therapy for SCCVII tumors in mice.
Topics: Animals; Borohydrides; Boron Compounds; Carcinoma, Squamous Cell; Cell Division; Drug Synergism; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Neutron Capture Therapy; Phenylalanine; Sulfhydryl Compounds; Tumor Stem Cell Assay | 1999 |
Pharmacokinetics of 10B-p-boronophenylalanine in tumours, skin and blood of melanoma patients: a study of boron neutron capture therapy for malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Boron Compounds; Boron Neutron Capture Therapy; Female; Humans; Male; Melanoma; Middle Aged; Phenylalanine; Skin; Skin Neoplasms; Time Factors | 1999 |
Effect of dose and infusion time on the delivery of p-boronophenylalanine for neutron capture therapy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioblastoma; Gliosarcoma; Infusions, Intravenous; Metabolic Clearance Rate; Phenylalanine; Radiation-Sensitizing Agents; Rats; Tissue Distribution; Tumor Cells, Cultured | 1999 |
Repair of potentially lethal damage by total and quiescent cells in solid tumors following a neutron capture reaction.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Division; Cytochalasin B; DNA Damage; Dose-Response Relationship, Radiation; Female; Gamma Rays; Mice; Mice, Inbred C3H; Micronucleus Tests; Neoplasm Transplantation; Phenylalanine; Sensitivity and Specificity; Sulfhydryl Compounds; Tumor Cells, Cultured | 1999 |
Boron self-shielding effects on dose delivery of neutron capture therapy using epithermal beam and boronophenylalanine.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Humans; Models, Statistical; Monte Carlo Method; Phantoms, Imaging; Phenylalanine; Radiation Protection; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1999 |
Mechanisms of transport of p-borono-phenylalanine through the cell membrane in vitro.
Topics: Animals; Biological Transport; Boron Compounds; Cell Line; Cricetinae; Cricetulus; Phenylalanine; Rats; Spectrophotometry, Atomic; Tumor Cells, Cultured | 2000 |
Studies on the structure of the complex of the boron neutron capture therapy drug, L-p-boronophenylalanine, with fructose and related carbohydrates: chemical and 13C NMR evidence for the beta-D-fructofuranose 2,3,6-(p-phenylalanylorthoboronate) structure.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Carbon Isotopes; Disaccharides; Fructose; Kinetics; Molecular Conformation; Monosaccharides; Nuclear Magnetic Resonance, Biomolecular; Phenylalanine; Radiation-Sensitizing Agents | 2000 |
Postmortem neuropathological features secondary to boron neutron capture therapy for glioblastoma multiforme.
Topics: Adult; Aged; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Lewy Bodies; Male; Middle Aged; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Phenylalanine; Radiation-Sensitizing Agents | 2000 |
Boron neutron capture therapy of brain tumors: enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine.
Topics: Animals; Blood-Brain Barrier; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Glioma; Injections, Intra-Arterial; Phenylalanine; Radiation-Sensitizing Agents; Radiobiology; Radiotherapy Dosage; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Time Factors | 2000 |
Biodistribution of boron concentration on melanoma-bearing hamsters after administration of p-, m-, o-boronophenylalanine.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cricetinae; Male; Melanins; Melanoma, Experimental; Mesocricetus; Mice; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution | 2000 |
Uptake and washout of borocaptate sodium and borono-phenylalanine in cultured melanoma cells: a multi-nuclear NMR study.
Topics: Animals; Biological Transport; Borohydrides; Boron Compounds; Culture Media; Melanoma; Mice; Nuclear Magnetic Resonance, Biomolecular; Perfusion; Phenylalanine; Radiation-Sensitizing Agents; Signal Transduction; Sulfhydryl Compounds; Tumor Cells, Cultured | 2000 |
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene.
Topics: Animals; Boron Compounds; Gene Expression; Humans; Melanins; Melanoma, Amelanotic; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Phenylalanine; Radiation-Sensitizing Agents; Transfection; Tumor Cells, Cultured | 2000 |
Improved survival after boron neutron capture therapy of brain tumors by Cereport-mediated blood-brain barrier modulation to enhance delivery of boronophenylalanine.
Topics: Animals; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Bradykinin; Brain Neoplasms; Glioma; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Survival Rate; Tissue Distribution | 2000 |
Determination of boronophenylalanine in biological samples using precolumn o-phthalaldehyde derivatization and reversed-phase high-performance liquid chromatography.
Topics: Animals; Boron Compounds; Chromatography, High Pressure Liquid; Indicators and Reagents; Male; o-Phthalaldehyde; Phenylalanine; Rats; Rats, Wistar; Reference Standards; Spectrometry, Fluorescence | 2000 |
Thymic selection generates T cells expressing self-reactive TCRs in the absence of CD45.
Topics: Animals; Boron Compounds; CD4 Antigens; CD8 Antigens; Cell Differentiation; Cell Fusion; Epitopes, T-Lymphocyte; Hybridomas; Interleukin-2; Leukocyte Common Antigens; Lymphocyte Activation; Major Histocompatibility Complex; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Peptides; Phenylalanine; Receptors, Antigen, T-Cell; Spleen; T-Lymphocyte Subsets; Thymus Gland; Tumor Cells, Cultured | 2000 |
Tolerance of the normal canine brain to epithermal neutron irradiation in the presence of p-boronophenylalanine.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain; Dogs; Lymphocyte Count; Magnetic Resonance Imaging; Muscle, Skeletal; Neutrons; Phenylalanine; Platelet Count; Radiation Dosage; Radiation-Sensitizing Agents; Scalp | 2000 |
Dual control of melanogenesis and melanoma growth: overview molecular to clinical level and the reverse.
Topics: Animals; Boron Compounds; Humans; Indolequinones; Indoles; Melanins; Melanoma; Melanosis; Phenylalanine; Quinones; Skin Pigmentation; Subcellular Fractions | 2000 |
Boron neutron capture therapy of brain tumors: functional and neuropathologic effects of blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine.
Topics: Animals; Blood-Brain Barrier; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Carotid Artery, Internal; Cerebral Hemorrhage; Cognition; Eye; Eye Diseases; Injections, Intra-Arterial; Male; Motor Activity; Neurotoxins; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Tissue Distribution | 2000 |
Boron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Drug Carriers; Female; Hindlimb; Hydrophobic and Hydrophilic Interactions; Injections, Intraperitoneal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Phenylalanine; Sulfhydryl Compounds; Thorax; Tissue Distribution | 2001 |
Evaluation of the genotoxic effects of the boron neutron capture reaction in human melanoma cells using the cytokinesis block micronucleus assay.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Division; Cell Line; Cells, Cultured; Cricetinae; Drug Carriers; Fast Neutrons; Humans; Isotopes; Melanoma; Micronucleus Tests; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2001 |
Evaluation of apoptosis and micronucleation induced by reactor neutron beams with two different cadmium ratios in total and quiescent cell populations within solid tumors.
Topics: Animals; Apoptosis; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Bromodeoxyuridine; Cadmium; Carcinoma, Squamous Cell; Cytochalasin B; Fluorescent Antibody Technique; Lymphoma; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Micronucleus Tests; Neoplasms; Neutrons; Phenylalanine; Radiation Tolerance; Radiation-Sensitizing Agents; Radiobiology; Radioisotopes; Relative Biological Effectiveness; Sarcoma, Experimental; Sulfhydryl Compounds; Tumor Cells, Cultured | 2001 |
Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Drug Administration Schedule; Gliosarcoma; Infusions, Intravenous; Isotopes; Male; Phenylalanine; Rats; Rats, Inbred F344; Spectrometry, Mass, Secondary Ion | 2001 |
Boron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Boron Compounds; Boron Neutron Capture Therapy; Carcinogens; Cheek; Cricetinae; Disease Models, Animal; Mesocricetus; Mouth Neoplasms; Phenylalanine; Precancerous Conditions; Radiation-Sensitizing Agents | 2001 |
The hamster cheek pouch as a model of oral cancer for boron neutron capture therapy studies: selective delivery of boron by boronophenylalanine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinogens; Cheek; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Mesocricetus; Mouth Neoplasms; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution | 2001 |
Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain.
Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Isotopes; Melanins; Melanoma, Amelanotic; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2002 |
Selective uptake of p-borophenylalanine by undifferentiated thyroid carcinoma for boron neutron capture therapy.
Topics: Adenoma; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cattle; Cell Division; Cells, Cultured; Humans; Isotopes; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured | 2002 |
Neutron capture therapy of intracerebral melanoma: enhanced survival and cure after blood-brain barrier opening to improve delivery of boronophenylalanine.
Topics: Animals; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Bradykinin; Brain Neoplasms; Humans; Mannitol; Melanoma; Osmosis; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Nude | 2002 |
Imaging of fluorine and boron from fluorinated boronophenylalanine in the same cell at organelle resolution by correlative ion microscopy and confocal laser scanning microscopy.
Topics: Boron; Boron Compounds; Brain Neoplasms; Fluorine; Glioblastoma; Humans; Image Processing, Computer-Assisted; Ions; Microscopy, Confocal; Mitochondria; Models, Chemical; Phenylalanine; Radiation-Sensitizing Agents; Time Factors; Tomography, Emission-Computed; Tumor Cells, Cultured | 2002 |
Mutagenic effect of borocaptate sodium and boronophenylalanine in neutron capture therapy.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cell Survival; CHO Cells; Cricetinae; Mutagenicity Tests; Mutation; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 2002 |
Long-term infusions of p-boronophenylalanine for boron neutron capture therapy: evaluation using rat brain tumor and spinal cord models.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Male; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Rats; Rats, Inbred F344; Spinal Cord; Time Factors; X-Rays | 2002 |
The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell-nucleus-addressed deca-p-boronophenylalanine.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma; Cell Nucleus; Cell Survival; Female; Flow Cytometry; HeLa Cells; Humans; Mass Spectrometry; Microscopy, Confocal; Molecular Sequence Data; Phenylalanine; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 2003 |
Delivery of (10)boron to oral squamous cell carcinoma using boronophenylalanine and borocaptate sodium for boron neutron capture therapy.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Female; Isotopes; Mice; Mice, Nude; Mouth Neoplasms; Phenylalanine; Relative Biological Effectiveness; Sulfhydryl Compounds | 2004 |
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Division; Glioma; Humans; Male; Mice; Mice, Inbred C3H; Mice, Nude; Middle Aged; Phenylalanine; Phosphorylation; Rats; Rats, Inbred F344; Spectrometry, Mass, Secondary Ion; Subcellular Fractions; Thymidine; Thymidine Kinase | 2004 |
Synthesis and in vivo biodistribution of BPA-Gd-DTPA complex as a potential MRI contrast carrier for neutron capture therapy.
Topics: Animals; Autoradiography; Boron Compounds; Boron Neutron Capture Therapy; Contrast Media; Gadolinium DTPA; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Phenylalanine; Rats; Spectrophotometry, Infrared; Tissue Distribution | 2005 |
Distribution of BPA and metabolic assessment in glioblastoma patients during BNCT treatment: a microdialysis study.
Topics: Blood Glucose; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Glioblastoma; Humans; Microdialysis; Phenylalanine; Radiation-Sensitizing Agents | 2005 |
Approach to magnetic neutron capture therapy.
Topics: Boron; Boron Compounds; Carbon; Drug Carriers; Iron; Magnetics; Nanotechnology; Neutron Capture Therapy; Phenylalanine | 2005 |
Analysis of 10B antitumoral compounds by means of flow-injection into ESI-MS/MS.
Topics: Adult; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Clinical Trials, Phase I as Topic; Humans; Isotopes; Middle Aged; Phenylalanine; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2005 |
Capillary electrophoresis-electrospray mass spectrometry and HR-ICP-MS for the detection and quantification of 10B-boronophenylalanine (10B-BPA) used in boron neutron capture therapy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Electrophoresis, Capillary; Endothelial Cells; Glioma; Humans; Isotopes; Mass Spectrometry; Molecular Structure; Phenylalanine; Rats; Sensitivity and Specificity; Time Factors | 2006 |
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Growth Processes; Combined Modality Therapy; Cricetinae; Female; Genetic Therapy; Injections, Intralesional; Melanoma, Amelanotic; Mesocricetus; Monophenol Monooxygenase; Phenylalanine; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms; Tissue Distribution; Transfection | 2006 |
First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA PET.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Mucoepidermoid; Female; Fluorine Radioisotopes; Humans; Middle Aged; Phenylalanine; Positron-Emission Tomography; Radiotherapy Dosage; Submandibular Gland Neoplasms | 2006 |
Synthesis of bis-armed amino acid derivatives via the alkylation of ethyl isocyanoacetate and the Suzuki-Miyaura cross-coupling reaction.
Topics: Acetates; Alkylation; Amino Acids, Aromatic; Amino Acids, Dicarboxylic; Boron Compounds; Catalysis; Palladium; Phenylalanine | 2007 |
Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative.
Topics: Alcohols; Boron Compounds; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Molecular Probes; Phenylalanine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2007 |
Assessment of chemical purity of 10B-enriched p-boronophenylalanine by high-performance liquid chromatography coupled on-line with inductively coupled plasma optical emission spectrometry.
Topics: Boron; Boron Compounds; Buffers; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Phenylalanine; Radiation-Sensitizing Agents; Spectrophotometry; Spectrophotometry, Ultraviolet; Tyrosine | 2007 |
Biological evaluation of fluorinated p-boronophenylalanine derivatives as a boron carrier.
Topics: Animals; Antineoplastic Agents; Boron; Boron Compounds; Cell Survival; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Glioma; Hydrocarbons, Fluorinated; Ion Transport; Models, Biological; Phenylalanine; Rats; Solubility; Tumor Cells, Cultured | 2007 |
Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: towards a novel therapy for liver metastases.
Topics: Animals; Body Weight; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; DNA; Dose-Response Relationship, Radiation; Hepatocytes; Humans; Kidney; Liver; Liver Neoplasms; Liver Regeneration; Male; Organ Size; Phenylalanine; Radiotherapy Dosage; Rats; Rats, Wistar | 2007 |
Optimization of boron neutron capture therapy for the treatment of undifferentiated thyroid cancer.
Topics: Animals; Apoptosis; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Deuteroporphyrins; Disease-Free Survival; Drug Therapy, Combination; Humans; Male; Mice; Mice, Nude; Niacinamide; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Remission Induction; Thyroid Neoplasms; Tissue Distribution | 2007 |
Quantitative subcellular imaging of boron compounds in individual mitotic and interphase human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS).
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line; Glioblastoma; Humans; Interphase; Mitosis; Phenylalanine; Spectrometry, Mass, Secondary Ion | 2008 |
Effect of neutron capture therapy on the cell cycle of human squamous cell carcinoma cells.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Humans; Mouth Neoplasms; Phenylalanine; Tumor Suppressor Protein p53 | 2008 |
A genetically encoded boronate-containing amino acid.
Topics: Boron Compounds; Escherichia coli; Phenylalanine; Protein Biosynthesis; Proteins; RNA, Transfer | 2008 |
An international dosimetry exchange for BNCT part II: computational dosimetry normalizations.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Clinical Trials as Topic; Humans; Isotopes; Neoplasms; Phantoms, Imaging; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Reproducibility of Results; Software; Treatment Outcome | 2008 |
L-amino acid transporter-1 and boronophenylalanine-based boron neutron capture therapy of human brain tumors.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Proliferation; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Phenylalanine; Proliferating Cell Nuclear Antigen | 2009 |
Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA.
Topics: Animals; Boric Acids; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Clone Cells; Hepatocytes; Humans; Liver Neoplasms; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Tissue Distribution | 2009 |
Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Glioma; In Vitro Techniques; Levodopa; Magnetic Resonance Imaging; Male; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Wistar | 2009 |
Dose distribution and clinical response of glioblastoma treated with boron neutron capture therapy.
Topics: Adult; Aged; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phenylalanine; Photons; Radiotherapy Dosage; Retrospective Studies; Sulfhydryl Compounds; Survival Rate; Treatment Failure | 2009 |
Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: an experimental study that supports a potential new application of BNCT.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cricetinae; Mouth Neoplasms; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Phenylalanine; Precancerous Conditions; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tissue Distribution | 2009 |
Biodistribution of BPA and BSH after single, repeated and simultaneous administrations for neutron-capture therapy of cancer.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cricetinae; Female; Isotopes; Melanoma, Experimental; Mesocricetus; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tissue Distribution | 2009 |
Feasibility of boron neutron capture therapy for malignant spinal tumors.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Computer Simulation; Humans; Phantoms, Imaging; Phenylalanine; Positron-Emission Tomography; Radiation Injuries; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Spinal Cord Injuries; Spinal Cord Neoplasms | 2009 |
Extra-corporeal liver BNCT for the treatment of diffuse metastases: what was learned and what is still to be learned.
Topics: Adult; Boron Compounds; Boron Neutron Capture Therapy; Cardiomyopathy, Dilated; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Extracorporeal Circulation; Humans; Liver Neoplasms; Male; Middle Aged; Necrosis; Phenylalanine; Radiation Injuries; Radiation-Sensitizing Agents; Rectal Neoplasms; Tomography, X-Ray Computed | 2009 |
Selective uptake of p-boronophenylalanine by osteosarcoma cells for boron neutron capture therapy.
Topics: Animals; Biological Transport, Active; Bone Neoplasms; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Survival; In Vitro Techniques; Isotopes; Male; Osteosarcoma; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2009 |
Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Disease Models, Animal; In Vitro Techniques; Lung Neoplasms; Phenylalanine; Radiation Tolerance; Radiation-Sensitizing Agents; Rats | 2009 |
Boron neutron capture therapy for recurrent oral cancer and metastasis of cervical lymph node.
Topics: Adult; Aged; Aged, 80 and over; Boron Compounds; Boron Neutron Capture Therapy; Female; Fluorine Radioisotopes; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck; Neoplasm Recurrence, Local; Pain; Phenylalanine; Positron-Emission Tomography; Quality of Life; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tomography, X-Ray Computed | 2009 |
Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients.
Topics: Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Clinical Protocols; Combined Modality Therapy; Glioblastoma; Humans; Japan; Phenylalanine; Prognosis; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Survival Rate | 2009 |
T2 corrected quantification method of L-p-boronophenylalanine using proton magnetic resonance spectroscopy for boron neutron capture therapy.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Humans; Isotopes; Magnetic Resonance Spectroscopy; Phantoms, Imaging; Phenylalanine; Protons; Radiation-Sensitizing Agents | 2009 |
Comparison of BNCT and GdNCT efficacy in treatment of canine cancer.
Topics: Animals; Bone Neoplasms; Boron Compounds; Boron Neutron Capture Therapy; Combined Modality Therapy; Dog Diseases; Dogs; Gadolinium; Humans; Melanoma; Mouth Neoplasms; Neoplasms; Neutron Capture Therapy; Osteosarcoma; Phenylalanine | 2009 |
Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Drug Delivery Systems; Humans; Isotopes; Lipopeptides; Liposomes; Membrane Potentials; Neoplasms; Particle Size; Phenylalanine; Radiation-Sensitizing Agents; tat Gene Products, Human Immunodeficiency Virus | 2009 |
Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents.
Topics: Animals; Antibodies, Monoclonal; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; ErbB Receptors; Glioma; Head and Neck Neoplasms; Humans; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Rats; Rats, Inbred F344 | 2009 |
A simple and rapid method for measurement of (10)B-para-boronophenylalanine in the blood for boron neutron capture therapy using fluorescence spectrophotometry.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Humans; Mice; Mice, Inbred C3H; Phenylalanine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Sulfhydryl Compounds | 2009 |
Evolution of proteins with genetically encoded "chemical warheads".
Topics: Antibodies; Boron Compounds; Codon, Nonsense; Escherichia coli; Escherichia coli Proteins; Evolution, Molecular; Humans; Mutation; Phenylalanine; Polysaccharides; Protein Engineering; Selection, Genetic | 2009 |
Metabolism of borono-phenylalanine-fructose complex (BPA-fr) and borocaptate sodium (BSH) in cancer patients--results from EORTC trial 11001.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Clinical Trials as Topic; Fructose; Head and Neck Neoplasms; Humans; Magnetic Resonance Spectroscopy; Phenylalanine; Sulfhydryl Compounds; Time Factors | 2010 |
Biodistribution of (10)B for Boron Neutron Capture Therapy (BNCT) in a mouse model after injection of sodium mercaptoundecahydro-closo-dodecaborate and l-para-boronophenylalanine.
Topics: Animals; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Drug Therapy, Combination; Injections; Isotopes; Male; Mice; Organ Specificity; Phenylalanine; Sulfhydryl Compounds; Tissue Distribution | 2009 |
Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis.
Topics: Animals; Azides; Base Sequence; Benzophenones; Boron Compounds; Cell Line; Codon, Nonsense; Genetic Engineering; Green Fluorescent Proteins; Macrophages; Methanococcus; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Phenylalanine; Plasmids; RNA, Transfer, Tyr; Transformation, Genetic; Tyrosine-tRNA Ligase | 2010 |
Early effect of boron neutron capture therapy mediated by boronophenylalanine (BPA-BNCT) on mast cells in premalignant tissue and tumors of the hamster cheek pouch.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Count; Cell Line, Tumor; Cell Proliferation; Cheek; Cricetinae; Mast Cells; Mouth Neoplasms; Phenylalanine; Precancerous Conditions; Radiation-Sensitizing Agents | 2010 |
First evaluation of the biologic effectiveness factors of boron neutron capture therapy (BNCT) in a human colon carcinoma cell line.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Carcinoma; Cell Line, Tumor; Cell Survival; Cobalt Radioisotopes; Colonic Neoplasms; Deuteroporphyrins; DNA Damage; Gamma Rays; Humans; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nuclear Reactors; Phenylalanine; Radiation-Sensitizing Agents; Relative Biological Effectiveness | 2011 |
Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Flow Cytometry; Gamma Rays; Glioblastoma; Humans; Microscopy, Electron, Transmission; Neutrons; Phenylalanine; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Time Factors | 2010 |
Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Female; Genes, p53; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Mouth Neoplasms; Mutation; Neoplasm Transplantation; Phenotype; Phenylalanine; Radiation-Sensitizing Agents | 2011 |
Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Humans; In Vitro Techniques; Melanoma, Experimental; Microscopy, Electron; Phenylalanine; Sarcoma, Clear Cell | 2011 |
Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models.
Topics: Adolescent; Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Phenylalanine; Sarcoma, Clear Cell; Tissue Distribution | 2011 |
Low dose of gamma irradiation enhanced boronophenylalanine uptake in head and neck carcinoma cells for boron neutron capture therapy.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cell Division; Dose-Response Relationship, Radiation; G2 Phase; Gamma Rays; Head and Neck Neoplasms; Phenylalanine | 2011 |
Studies for the application of boron neutron capture therapy to the treatment of differentiated thyroid cancer.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Differentiation; Cell Line, Tumor; Humans; Mice; Mice, Nude; Phenylalanine; Thyroid Neoplasms | 2011 |
Artificial neural networks to evaluate the boron concentration decreasing profile in blood-BPA samples of BNCT patients.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Humans; Neural Networks, Computer; Phenylalanine | 2011 |
Boron Neutron Capture Therapy (BNCT) in an oral precancer model: therapeutic benefits and potential toxicity of a double application of BNCT with a six-week interval.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; DNA; Mouth Neoplasms; Mucositis; Phenylalanine; Precancerous Conditions; Radiation Injuries, Experimental; Treatment Outcome | 2011 |
Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer.
Topics: Angiogenesis Inhibitors; Animals; Blood Vessels; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Radiation; Mouth Neoplasms; Phenylalanine; Thalidomide; Treatment Outcome | 2012 |
Macro- and microdistributions of boron drug for boron neutron capture therapy in an animal model.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Fluorine Radioisotopes; Fructose; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Phenylalanine; Positron-Emission Tomography; Xenograft Model Antitumor Assays | 2012 |
Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Drug Interactions; Female; Head and Neck Neoplasms; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution; Treatment Outcome | 2013 |
Induced radioactivity in the blood of cancer patients following Boron Neutron Capture Therapy.
Topics: Blood; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Deuterium Oxide; Equipment Design; Gamma Rays; Germanium; Humans; Lung; Neck; Neoplasms; Neutrons; Phenylalanine; Radiometry; Radiotherapy Dosage; Regression Analysis; Skin; Sodium Isotopes; Sulfhydryl Compounds | 2013 |
Predominant contribution of L-type amino acid transporter to 4-borono-2-(18)F-fluoro-phenylalanine uptake in human glioblastoma cells.
Topics: Amino Acid Transport Systems; Biological Transport; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methionine; Phenylalanine; Positron-Emission Tomography | 2013 |
Improvement of the boron neutron capture therapy (BNCT) by the previous administration of the histone deacetylase inhibitor sodium butyrate for the treatment of thyroid carcinoma.
Topics: Acetylation; Animals; Boron Compounds; Boron Neutron Capture Therapy; Butyric Acid; Cell Line, Tumor; Cell Survival; Histone Deacetylase Inhibitors; Histones; Humans; Mice; Mice, Nude; Phenylalanine; Radiation Dosage; Radiation-Sensitizing Agents; Thyroid Neoplasms | 2013 |
Sonoporation as an enhancing method for boron neutron capture therapy for squamous cell carcinomas.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Membrane; Female; Humans; Isotopes; Mice; Mice, Inbred BALB C; Mice, Nude; Microbubbles; Mouth Neoplasms; Neoplasm Transplantation; Neutrons; Phenylalanine; Radiotherapy; Ultrasonics | 2013 |
Glioblastoma, brain metastases and soft tissue sarcoma of extremities: candidate tumors for BNCT.
Topics: Animals; Borohydrides; Boron Compounds; Brain Neoplasms; Cell Line, Tumor; Extremities; Glioblastoma; Humans; Male; Mice; Mice, Nude; Phenylalanine; Radiotherapy Dosage; Sarcoma; Sulfhydryl Compounds; Tissue Distribution | 2014 |
Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: combined administration of BSH and BPA.
Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Drug Combinations; Mesocricetus; Metabolic Clearance Rate; Mouth Neoplasms; Organ Specificity; Phenylalanine; Radiotherapy Dosage; Sulfhydryl Compounds; Tissue Distribution; Treatment Outcome | 2014 |
Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Drug Combinations; Lung Neoplasms; Metabolic Clearance Rate; Organ Specificity; Phenylalanine; Radiotherapy Dosage; Rats; Tissue Distribution | 2014 |
Dose-rate effect was observed in T98G glioma cells following BNCT.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Cricetulus; DNA Damage; Dose-Response Relationship, Radiation; Glioblastoma; Humans; Phenylalanine; Radiotherapy Dosage; Treatment Outcome | 2014 |
Intracellular boron accumulation in CHO-K1 cells using amino acid transport control.
Topics: Amino Acid Transport Systems; Animals; Boron Compounds; Boron Neutron Capture Therapy; CHO Cells; Cricetinae; Cricetulus; Drug Carriers; Metabolic Clearance Rate; Phenylalanine; Tyrosine | 2014 |
Boron neutron capture therapy as new treatment for clear cell sarcoma: trial on different animal model.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Female; Humans; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Muscle Neoplasms; Organ Specificity; Phenylalanine; Sarcoma, Clear Cell; Tissue Distribution; Treatment Outcome | 2014 |
Effects of l-DOPA pre-loading on the uptake of boronophenylalanine using the F98 glioma and B16 melanoma models.
Topics: Animals; Boron Compounds; Brain Neoplasms; Drug Synergism; Female; Glioma; Levodopa; Melanoma; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Organ Specificity; Phenylalanine; Premedication; Tissue Distribution; Treatment Outcome | 2014 |
Pharmacokinetic analysis and uptake of 18F-FBPA-Fr after ultrasound-induced blood-brain barrier disruption for potential enhancement of boron delivery for neutron capture therapy.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Boron Compounds; Brain Neoplasms; Drug Delivery Systems; Glioma; Glycopeptides; In Situ Nick-End Labeling; Male; Neoplasm Transplantation; Neutron Capture Therapy; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred F344; Ultrasonics | 2014 |
(10)B-NMR determination of (10)B-BPA, (10)B-BPA-fructose complex and total (10)B in blood for BNCT.
Topics: Blood Chemical Analysis; Boron; Boron Compounds; Boron Neutron Capture Therapy; Fructose; Humans; Isotopes; Magnetic Resonance Spectroscopy; Phenylalanine; Reproducibility of Results; Sensitivity and Specificity | 2014 |
Quantitative evaluation of boron neutron capture therapy (BNCT) drugs for boron delivery and retention at subcellular-scale resolution in human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS).
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Calcium; Cell Line, Tumor; Cell Tracking; Glioblastoma; Humans; Intracellular Space; Isotopes; Microscopy, Confocal; Phenylalanine; Potassium; Sodium; Spectrometry, Mass, Secondary Ion; Time Factors | 2014 |
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma.
Topics: Animals; Boron Compounds; Cell Line, Tumor; Disease Models, Animal; Heterografts; Humans; Melanoma, Amelanotic; Mice; Mice, Inbred BALB C; Mice, Nude; Phenylalanine; Skin Neoplasms | 2014 |
Assessment of biological effectiveness of boron neutron capture therapy in primary and metastatic melanoma cell lines.
Topics: Autoradiography; Biological Transport; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Humans; Intracellular Space; Melanoma; Neoplasm Metastasis; Phenylalanine; Radiation Tolerance; Relative Biological Effectiveness | 2015 |
Blood-brain barrier (BBB) toxicity and permeability assessment after L-(4-¹⁰Boronophenyl)alanine, a conventional B-containing drug for boron neutron capture therapy, using an in vitro BBB model.
Topics: Animals; Blood-Brain Barrier; Boron; Boron Compounds; Brain; Capillary Permeability; Cattle; Coculture Techniques; Cytoskeleton; Endothelial Cells; Neuroglia; Occludin; Phenylalanine; Pilot Projects; Rats; Tight Junctions; Vimentin; Zonula Occludens-1 Protein | 2014 |
The effectiveness of the high-LET radiations from the boron neutron capture [10B(n,α) 7Li] reaction determined for induction of chromosome aberrations and apoptosis in lymphocytes of human blood samples.
Topics: Apoptosis; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Chromosome Aberrations; Dose-Response Relationship, Radiation; Female; Humans; Isotopes; Linear Energy Transfer; Lithium; Lymphocytes; Male; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 2015 |
Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2.
Topics: Amino Acid Transport System y+; Amino Acid Transport System y+L; Amino Acid Transport Systems; Animals; Biological Transport; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Fusion Regulatory Protein 1, Light Chains; HeLa Cells; Humans; MCF-7 Cells; Neurotransmitter Transport Proteins; Oocytes; Phenylalanine; RNA Interference; RNA, Small Interfering; Xenopus | 2015 |
Detection of boronic acid derivatives in cells using a fluorescent sensor.
Topics: Antineoplastic Agents; Boron; Boron Compounds; Boronic Acids; Bortezomib; Cell Line, Tumor; Chelating Agents; Fluorescent Dyes; Humans; Optical Imaging; Phenylalanine; Spectrometry, Fluorescence | 2015 |
From the laboratory to the clinic: How translational studies in animals have lead to clinical advances in boron neutron capture therapy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Melanoma; Phenylalanine; Translational Research, Biomedical | 2015 |
Additive effect of BPA and Gd-DTPA for application in accelerator-based neutron source.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line; Cell Line, Tumor; Cricetinae; Gadolinium DTPA; Phenylalanine; Rats; Rats, Wistar | 2015 |
The N-B Interaction through a Water Bridge: Understanding the Chemoselectivity of a Fluorescent Protein Based Probe for Peroxynitrite.
Topics: Amino Acid Sequence; Boron; Boron Compounds; Crystallography, X-Ray; Fluorescent Dyes; Green Fluorescent Proteins; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Peroxynitrous Acid; Phenylalanine; Sequence Alignment; Spectrometry, Fluorescence; Water | 2016 |
Preloading with L-BPA, L-tyrosine and L-DOPA enhances the uptake of [
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Caco-2 Cells; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Humans; Levodopa; Mice; Neoplasms, Experimental; Phenylalanine; Propionates; Tyrosine; Up-Regulation | 2016 |
On the applicability of [
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Female; Humans; Liver Neoplasms; Mice; Phenylalanine; Positron-Emission Tomography | 2017 |
Novel Fluorescence-Based Biosensors Incorporating Unnatural Amino Acids.
Topics: Animals; Biosensing Techniques; Boron Compounds; Fluorescent Dyes; Humans; Hydrogen Peroxide; Luminescent Proteins; Models, Molecular; Phenylalanine; Protein Engineering; Spectrometry, Fluorescence | 2017 |
Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy.
Topics: Adaptor Proteins, Signal Transducing; Boron Compounds; Boron Neutron Capture Therapy; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Large Neutral Amino Acid-Transporter 1; Oxygen; Phenylalanine; RNA, Messenger | 2018 |
Catalytic asymmetric synthesis of α-methyl-p-boronophenylalanine.
Topics: Alkylation; Boron Compounds; Catalysis; Coordination Complexes; Palladium; Phenylalanine; Stereoisomerism | 2018 |
Structural Basis for the Specific Cotranslational Incorporation of p-Boronophenylalanine into Biosynthetic Proteins.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Boron Compounds; Crystallography, X-Ray; Escherichia coli; Methanocaldococcus; Mutation; Phenylalanine; Protein Conformation; Protein Engineering; Recombinant Proteins; RNA, Transfer; Substrate Specificity; Tyrosine | 2018 |
Resurrecting the Bacterial Tyrosyl-tRNA Synthetase/tRNA Pair for Expanding the Genetic Code of Both E. coli and Eukaryotes.
Topics: Animals; Archaeal Proteins; Boron Compounds; Directed Molecular Evolution; Escherichia coli; Escherichia coli Proteins; Genetic Code; HEK293 Cells; Humans; Models, Molecular; Phenylalanine; RNA, Transfer; Tyrosine-tRNA Ligase | 2018 |
Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.
Topics: Animals; Biological Transport; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Peptide Transporter 1; Phenylalanine; Symporters; Tyrosine; Up-Regulation; Xenograft Model Antitumor Assays | 2019 |
Cellular uptake evaluation of pentagamaboronon-0 (PGB-0) for boron neutron capture therapy (BNCT) against breast cancer cells.
Topics: Biological Transport; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Curcumin; Female; Humans; Phenylalanine; Radiation-Sensitizing Agents | 2019 |
Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
Topics: Animals; Antigens, Surface; Boron Compounds; Boron Neutron Capture Therapy; Boronic Acids; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Edetic Acid; Gallium Isotopes; Gallium Radioisotopes; Glutamate Carboxypeptidase II; Humans; Inhibitory Concentration 50; Ligands; Male; Mice; Mice, Nude; Oligopeptides; Phenylalanine; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiation-Sensitizing Agents; Tissue Distribution; Xenograft Model Antitumor Assays | 2019 |
A Tetrahedral Boronic Acid Diester Formed by an Unnatural Amino Acid in the Ligand Pocket of an Engineered Lipocalin.
Topics: Boron Compounds; Ligands; Lipocalins; Molecular Conformation; Phenylalanine; Protein Engineering; Thermodynamics | 2020 |
Comparison of
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Boron Compounds; Child; Female; Fluorodeoxyglucose F18; Humans; Male; Melanoma; Middle Aged; Phenylalanine; Positron-Emission Tomography; Young Adult | 2020 |
Poly(vinyl alcohol) boosting therapeutic potential of
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Energy Metabolism; Humans; Mass Spectrometry; Mice; Neoplasms; Phenylalanine; Polyvinyl Alcohol; Radiation-Sensitizing Agents; Signal Transduction; Tissue Distribution; Xenograft Model Antitumor Assays | 2020 |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy.
Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Death; Cell Line, Tumor; Cell Survival; Cobalt Radioisotopes; Computer Simulation; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Isotopes; Melanoma; Models, Biological; Monte Carlo Method; Neutrons; Phenylalanine; Radiometry; Relative Biological Effectiveness; Time Factors | 2020 |
Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Radiation; Humans; Linear Energy Transfer; Monte Carlo Method; Neoplasms; Phenylalanine; Radiometry; Radiotherapy, Conformal; Receptor, ErbB-2; Relative Biological Effectiveness; Trastuzumab | 2020 |
Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Fructose; Mice; Phenylalanine; Polymers | 2021 |
Influence of Boron Neutron Capture Therapy on Normal Liver Tissue.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Eosine Yellowish-(YS); Female; Fibrosis; Hedgehog Proteins; Hematoxylin; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Phenylalanine; Triglycerides | 2022 |
Development, Characterization, and Structural Analysis of a Genetically Encoded Red Fluorescent Peroxynitrite Biosensor.
Topics: Animals; Biosensing Techniques; Boronic Acids; Fluorescent Dyes; Green Fluorescent Proteins; Hydrogen Peroxide; Mammals; Peroxynitrous Acid; Phenylalanine | 2023 |