phenylahistin has been researched along with imidazole* in 1 studies
1 other study(ies) available for phenylahistin and imidazole
| Article | Year |
|---|---|
Synthesis and biological activities of phenylahistin derivatives.
X-ray crystallographic analysis was performed and several phenylahistin derivatives were synthesized to elucidate the structural components necessary for the anti-microtubule activity of phenylahistin. We primarily focused on the unique isoprenylated dehydrohistidine structure. Our results showed that a uniplanar pseudo-three-ring structure formed by the hydrogen bonding of diketopiperazine and imidazole rings is important for the anti-microtubule activity of phenylahistin. Topics: Animals; Antineoplastic Agents; Cattle; Crystallography, X-Ray; Diketopiperazines; Hydrogen Bonding; Imidazoles; Mice; Microtubules; Molecular Structure; Piperazines; Structure-Activity Relationship | 1999 |