phenylacetic acid and sodium benzoate

phenylacetic acid has been researched along with sodium benzoate in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (5.00)	18.2507
2000's	8 (40.00)	29.6817
2010's	9 (45.00)	24.3611
2020's	2 (10.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Thoene, JG	1
Boyadjiev, SA; Brusilow, SW; Geraghty, MT; Praphanphoj, V; Waber, LJ	1
Summar, M	1
Batshaw, ML; MacArthur, RB; Tuchman, M	1
Altincatal, A; MacArthur, RB; Tuchman, M	1
Carter, S; Lee, B; O'Brien, WE; Scaglia, F	1
Barletta, GM; Bunchman, TE; Crumb, TL; Gardner, JJ; McBryde, KD; Winters, JW	1
Berry, GT; Berry, SA; Brusilow, SW; Enns, GM; Hamosh, A; Rhead, WJ	1
Shih, VE	1
Fujisawa, T; Hayashi, H; Inui, A; Kobayashi, K; Komatsu, H; Miida, T; Nagasaka, H; Takatani, T; Takikawa, H; Tsukahara, H; Yorifuji, T	1
Houston, B; Merlo, C; Reiss, KA	1
Bain, KB; Byers, DE; Chen, C; Hachem, RR; Iuppa, JA; Patterson, GA; Trulock, EP; Witt, CA; Yusen, RD	1
de Koning, L; Gifford, JL; Khan, A; Orton, DJ; Seiden-Long, I	1
Bellinger, A; Berry, GT; Cohen, DE; Frank, NY; Gershanik, EF; Goldberg, AD; Levy, BD; Lin, AP; Lynch, R; McFaline-Figueroa, JR; Merugumala, SK; O'Donnell-Luria, AH; Rohr, F; Samuels, MA; Simon, T; Tchekmedyian, V; Waisbren, SE	1
de Sain-van der Velden, MGM; Favier, RP; Fieten, H; Holwerda-Loof, NE; Mesu, SJ; Rothuizen, J; Spee, B; van der Ham, M; van Geijlswijk, IM; van Straten, G; Verhoeven-Duif, NM	1
Akula, VP; Alcorn, D; Benitz, WE; Bernstein, JA; Berquist, WE; Blumenfeld, YJ; Castillo, RO; Concepcion, W; Cowan, TM; Cox, KL; Cusmano, K; Enns, GM; Esquivel, CO; Hintz, SR; Homeyer, M; Hudgins, L; Hurwitz, M; Lyell, DJ; Palma, JP; Schelley, S; Summar, ML; Wilnai, Y	1
Brossier, D; Goyer, I; Jouvet, P; Marquis, C; Mitchell, G; Ozanne, B; Ziani, L	1
Alhasan, K; Bagga, A; Basu, RK; Bedoyan, JK; Bunchman, T; Chakraborty, R; Filler, G; Grewal, MK; Jouvet, P; Krishnappa, V; Lichter-Konecki, U; Machado, MC; McCulloch, M; Mew, NA; Picca, S; Raina, R; Schaefer, F; Sethi, SK; Vemuganti, M; Warady, BA	1
Dote, N; Endo, F; Koumura, E; Nakamura, K; Sano, Y; Shimizu, K	1

Reviews

3 review(s) available for phenylacetic acid and sodium benzoate

Article	Year
Treatment of urea cycle disorders. The Journal of pediatrics, 1999, Volume: 134, Issue:3 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Antimetabolites; Child, Preschool; Drug Combinations; Humans; Infant; Infant, Newborn; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Sodium Benzoate; Urea	1999
Alternative pathway therapy for urea cycle disorders: twenty years later. The Journal of pediatrics, 2001, Volume: 138, Issue:1 Suppl Topics: Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Humans; Hyperammonemia; Phenylacetates; Phenylbutyrates; Sodium Benzoate; Urea	2001
Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy. Nature reviews. Nephrology, 2020, Volume: 16, Issue:8 Topics: Arginine; Carnitine; Child; Child, Preschool; Continuous Renal Replacement Therapy; Delphi Technique; Diet, Protein-Restricted; Humans; Hybrid Renal Replacement Therapy; Hyperammonemia; Infant; Infant, Newborn; Parenteral Nutrition; Peritoneal Dialysis; Phenylacetates; Phenylbutyrates; Practice Guidelines as Topic; Renal Dialysis; Sodium Benzoate; Urea Cycle Disorders, Inborn; Vitamin B Complex	2020

Trials

1 trial(s) available for phenylacetic acid and sodium benzoate

Article	Year
Survival after treatment with phenylacetate and benzoate for urea-cycle disorders. The New England journal of medicine, 2007, May-31, Volume: 356, Issue:22 Topics: Adolescent; Adult; Age Factors; Age of Onset; Amino Acid Metabolism, Inborn Errors; Ammonia; Carbamoyl-Phosphate Synthase I Deficiency Disease; Child; Child, Preschool; Citrullinemia; Female; Humans; Hyperammonemia; Infant; Infant, Newborn; Male; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Sodium Benzoate; Survival Analysis; Urea	2007

Article

Year

Survival after treatment with phenylacetate and benzoate for urea-cycle disorders.

The New England journal of medicine, 2007, May-31, Volume: 356, Issue:22

Topics: Adolescent; Adult; Age Factors; Age of Onset; Amino Acid Metabolism, Inborn Errors; Ammonia; Carbamoyl-Phosphate Synthase I Deficiency Disease; Child; Child, Preschool; Citrullinemia; Female; Humans; Hyperammonemia; Infant; Infant, Newborn; Male; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Sodium Benzoate; Survival Analysis; Urea

2007

Other Studies

16 other study(ies) available for phenylacetic acid and sodium benzoate

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Three cases of intravenous sodium benzoate and sodium phenylacetate toxicity occurring in the treatment of acute hyperammonaemia. Journal of inherited metabolic disease, 2000, Volume: 23, Issue:2 Topics: Child; Child, Preschool; Drug Overdose; Fatal Outcome; Female; Humans; Injections, Intravenous; Male; Metabolism, Inborn Errors; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Quaternary Ammonium Compounds; Sodium Benzoate; Urea	2000
Current strategies for the management of neonatal urea cycle disorders. The Journal of pediatrics, 2001, Volume: 138, Issue:1 Suppl Topics: Algorithms; Amino Acid Metabolism, Inborn Errors; Antimetabolites, Antineoplastic; Arginine; Dialysis; Extracorporeal Membrane Oxygenation; Humans; Hyperammonemia; Infant, Newborn; Phenylacetates; Sodium Benzoate; Urea	2001
Pharmacokinetics of sodium phenylacetate and sodium benzoate following intravenous administration as both a bolus and continuous infusion to healthy adult volunteers. Molecular genetics and metabolism, 2004, Volume: 81 Suppl 1 Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Hyperammonemia; Infusions, Intravenous; Molecular Structure; Phenylacetates; Prospective Studies; Sodium Benzoate; Time Factors	2004
Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients. Molecular genetics and metabolism, 2004, Volume: 81 Suppl 1 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids, Branched-Chain; Citrullinemia; Drug Therapy, Combination; Female; Humans; Male; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Phenylbutyrates; Retrospective Studies; Sodium Benzoate; Time Factors; Urea	2004
Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration. Pediatric nephrology (Berlin, Germany), 2007, Volume: 22, Issue:7 Topics: Ammonia; Hemofiltration; Humans; Hyperammonemia; Infant, Newborn; Phenylacetates; Renal Dialysis; Sodium Benzoate	2007
Alternative-pathway therapy for hyperammonemia. The New England journal of medicine, 2007, May-31, Volume: 356, Issue:22 Topics: Amino Acid Metabolism, Inborn Errors; Humans; Hyperammonemia; Phenylacetates; Sodium Benzoate; Urea	2007
Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children. Molecular genetics and metabolism, 2010, Volume: 100, Issue:2 Topics: Adenosine Triphosphatases; Adolescent; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Child, Preschool; Diet, Protein-Restricted; Female; Humans; Hyperammonemia; Liver; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Receptors, Cytoplasmic and Nuclear; Retrospective Studies; RNA, Messenger; Sodium Benzoate	2010
Healthy, but comatose. The American journal of medicine, 2011, Volume: 124, Issue:4 Topics: Adult; Brain Edema; Carbohydrates; Enteral Nutrition; Glucose; Humans; Hyperammonemia; Insulin; Male; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Renal Dialysis; Sodium Benzoate	2011
Hyperammonemia Syndrome After Lung Transplantation: A Single Center Experience. Transplantation, 2016, Volume: 100, Issue:3 Topics: Aged; Ammonia; Arginine; Biomarkers; Carnitine; Combined Modality Therapy; Decontamination; Female; Humans; Hyperammonemia; Immunosuppressive Agents; Lung Transplantation; Male; Middle Aged; Missouri; Phenylacetates; Protective Agents; Renal Dialysis; Retrospective Studies; Sodium Benzoate; Syndrome; Time Factors; Treatment Outcome; Up-Regulation	2016
Critically High Plasma Ammonia in an Adolescent Girl. Clinical chemistry, 2016, Volume: 62, Issue:12 Topics: Ammonia; Arginine; Child; Clinical Chemistry Tests; Diagnostic Errors; Fatigue; Female; Fever; Headache; Humans; Hyperammonemia; Phenylacetates; Reference Values; Sodium Benzoate	2016
Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma. Molecular genetics and metabolism, 2017, Volume: 121, Issue:1 Topics: Brain; Coma; Female; Gastric Bypass; Glutamates; Glutamine; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Middle Aged; Phenylacetates; Sodium Benzoate; Treatment Outcome	2017
Saline is as effective as nitrogen scavengers for treatment of hyperammonemia. Scientific reports, 2017, 10-13, Volume: 7, Issue:1 Topics: Animals; Dogs; Female; Hyperammonemia; Male; Nitrogen; Phenylacetates; Random Allocation; Saline Waters; Sodium Benzoate	2017
Prenatal treatment of ornithine transcarbamylase deficiency. Molecular genetics and metabolism, 2018, Volume: 123, Issue:3 Topics: Ammonia; Drug Combinations; Female; Glutamine; Humans; Hyperammonemia; Infant, Newborn; Male; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Pregnancy; Prenatal Care; Prenatal Diagnosis; Sodium Benzoate; Treatment Outcome; Urea	2018
Influence of implementing a protocol for an intravenously administered ammonia scavenger on the management of acute hyperammonemia in a pediatric intensive care unit. Journal of inherited metabolic disease, 2019, Volume: 42, Issue:1 Topics: Acute Disease; Ammonia; Canada; Child; Child, Preschool; Female; Humans; Hyperammonemia; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care Units, Pediatric; Male; Phenylacetates; Retrospective Studies; Sodium Benzoate	2019
Pharmacokinetics, safety, and tolerability of sodium phenylacetate and sodium benzoate in healthy Japanese volunteers: A phase I, single-center, open-label study. Drug metabolism and pharmacokinetics, 2023, Volume: 48 Topics: Adult; Benzoates; Child; East Asian People; Healthy Volunteers; Humans; Hyperammonemia; Infant; Phenylacetates; Sodium Benzoate	2023