phenylacetic acid has been researched along with phenylacetylglutamine in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Samid, D; Shack, S; Yeh, TJ | 1 |
| Brusilow, SW | 1 |
| Brusilow, SW; Rajantie, J; Simell, O; Sipilä, I; Valle, DL | 1 |
| Figg, WD; Headlee, D; Lieberman, R; Myers, CE; Piscitelli, SC; Samid, D; Thibault, A; Tompkins, A | 1 |
| Burzyński, SR; Sołtysiak-Pawłuczuk, D | 1 |
| Cline, GW; Katz, LD; Magnusson, I; Rothman, DL; Shulman, GI | 1 |
| Agarwal, KC; Beylot, M; Brunengraber, H; Soloviev, MV; Yang, D | 1 |
| Agarwal, KC; Beylot, M; Brunengraber, H; David, F; Dugelay, S; Fernandez, CA; Hazey, JW; Levine, WC; Previs, SF; Rinaldo, P; Soloviev, MV; Yang, D | 1 |
| Jeffrey, FM; Jones, JG; Malloy, CR; Sherry, AD; Solomon, MA | 1 |
| Burzynski, SR | 1 |
| Baker, SD; Bowling, MK; Carducci, MA; Donehower, RC; Figg, WD; Gilbert, J; Grochow, L; Zabelina, Y | 1 |
| Bowling, MK; Carducci, MA; Chen, TL; Donehower, RC; Eisenberger, MA; Gilbert, J; Grochow, LB; Noe, D; Sinibaldi, V; Zabelina, Y | 1 |
| Brunengraber, H; Comte, B; Dahms, W; Kasumov, T; Kerr, D; Nissim, I; Pierce, BA; Puchowicz, MA; Scott, ME | 1 |
| Adamson, P; Aiken, A; Balis, F; Berg, S; Blaney, SM; Jakacki, R; Klenke, R; Murry, DJ; Packer, R; Serabe, BM; Thompson, P | 1 |
| MEISTER, A; MOLDAVE, K | 1 |
| Beliveau, M; Berry, SA; Diaz, GA; Dickinson, K; Gargosky, S; Lee, B; Marier, JF; Martinez, A; Mauney, J; Mian, A; Mokhtarani, M; Rhead, W; Scharschmidt, BF; Shchelochkov, O | 1 |
| Herebian, D; Laryea, MD; Mayatepek, E; Meissner, T | 1 |
| Arranz, JA; Córdoba, J; Oria, M; Raguer, N; Riudor, E; Romero-Giménez, J | 1 |
| Bart, S; Bartholomew, D; Bartley, J; Berquist, W; Berry, SA; Cederbaum, S; Coakley, DF; Diaz, GA; Dickinson, K; Dorrani, N; Feigenbaum, A; Gallagher, R; Harding, CO; Korson, MS; Kronn, D; Lee, B; Lemons, C; Lichter-Konecki, U; Longo, N; McCandless, SE; Merritt, JL; Mokhtarani, M; Moors, TL; Rhead, W; Scharschmidt, BF; Smith, W; Sreenath-Nagamani, S; Summar, M; Vockley, J; Zori, R | 1 |
| Bartley, J; Berquist, W; Berry, SA; Brown, RS; Coakley, D; Diaz, GA; Dickinson, K; Feigenbaum, A; Gallagher, R; Ghabril, M; Harding, C; Lee, B; Lemons, C; Lichter-Konecki, U; Longo, N; Mantry, P; McCandless, SE; Milikien, DA; Mokhtarani, M; Moors, T; Nagamani, SC; Norris, C; Rhead, W; Rockey, DC; Scharschmidt, BF; Schulze, A; Smith, W; Vierling, JM | 1 |
| Figg, WD | 1 |
| Mak, C; Poola, N; Tseng, J; Vilchez, RA; Wang, X | 1 |
6 trial(s) available for phenylacetic acid and phenylacetylglutamine
| Article | Year |
|---|---|
Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine.
Topics: Adult; Aged; Female; Glutamine; Humans; Male; Middle Aged; Models, Biological; Neoplasms; Phenylacetates; Phenylbutyrates | 1995 |
A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Edema; Fatigue; Female; Glutamine; Humans; Hypocalcemia; Male; Middle Aged; Nausea; Neoplasms; Nervous System Diseases; Phenylacetates; Phenylbutyrates; Treatment Outcome; Vomiting | 2001 |
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Fatigue; Female; Glutamine; Humans; Hypokalemia; Infusions, Intravenous; Male; Metabolic Clearance Rate; Nausea; Neoplasms; Neutropenia; Patient Dropouts; Phenylacetates; Phenylbutyrates; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Uric Acid | 2001 |
Pharmacokinetics of phenylacetate administered as a 30-min infusion in children with refractory cancer.
Topics: Adolescent; Adult; Antineoplastic Agents; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Female; Glutamine; Half-Life; Humans; Infant; Infusions, Intravenous; Male; Models, Biological; Neoplasms; Phenylacetates; Spectrophotometry, Ultraviolet | 2003 |
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control.
Topics: Adult; Aged; Ammonia; Cross-Over Studies; Female; Glutamine; Glycerol; Humans; Male; Middle Aged; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn; Young Adult | 2010 |
Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders.
Topics: Adolescent; Adult; Ammonia; Biomarkers, Pharmacological; Child; Cross-Over Studies; Drug Administration Schedule; Female; Glutamine; Glycerol; Humans; Male; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn | 2012 |
16 other study(ies) available for phenylacetic acid and phenylacetylglutamine
| Article | Year |
|---|---|
Interferon in combination with antitumourigenic phenyl derivatives: potentiation of IFN alpha activity in-vitro.
Topics: Cell Division; Cell Line; Drug Synergism; Glutamine; Humans; In Vitro Techniques; Interferon-alpha; Phenylacetates; Tumor Cells, Cultured | 1991 |
Phenylacetylglutamine may replace urea as a vehicle for waste nitrogen excretion.
Topics: Adolescent; Child; Child, Preschool; Female; Glutamine; Humans; Infant; Male; Metabolism, Inborn Errors; Nitrogen; Phenylacetates; Phenylbutyrates; Urea | 1991 |
Waste nitrogen excretion via amino acid acylation: benzoate and phenylacetate in lysinuric protein intolerance.
Topics: Acylation; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Benzoates; Benzoic Acid; Child; Child, Preschool; Creatinine; Glutamine; Hippurates; Humans; Lysine; Nitrogen; Orotic Acid; Phenylacetates; Urea | 1986 |
Cellular accumulation of antineoplaston AS21 in human hepatoma cells.
Topics: Anions; Antineoplastic Agents; Biological Transport; Carcinoma, Hepatocellular; Drug Combinations; Glutamine; Humans; In Vitro Techniques; Phenylacetates; Sodium; Temperature; Tumor Cells, Cultured | 1995 |
13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.
Topics: Acetaminophen; Adult; Carbon Isotopes; Citric Acid Cycle; Diabetes Mellitus, Type 1; Female; Glucose; Glucose Clamp Technique; Glutamine; Humans; Hyperglycemia; Liver; Liver Glycogen; Magnetic Resonance Spectroscopy; Male; Models, Biological; Phenylacetates; Pyruvate Dehydrogenase Complex; Uridine Diphosphate Glucose | 1994 |
Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry.
Topics: Adult; Citric Acid Cycle; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Glutamine; Humans; Liver; Molecular Probes; Phenylacetates; Phenylalanine; Sensitivity and Specificity | 1993 |
Noninvasive probing of citric acid cycle intermediates in primate liver with phenylacetylglutamine.
Topics: Animals; Carbon Isotopes; Citric Acid Cycle; Female; Glutamic Acid; Glutamine; Ketoglutaric Acids; Kidney; Lactic Acid; Liver; Macaca mulatta; Muscles; Phenylacetates | 1996 |
13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen.
Topics: Acetaminophen; Adult; Blood Glucose; Carbon Isotopes; Female; Gluconeogenesis; Glucuronates; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Phenylacetates; Propionates; Pyruvates | 1998 |
Efficacy of antineoplastons A10 and AS2-1.
Topics: Antineoplastic Agents; Benzeneacetamides; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Glioma; Glutamine; Humans; National Institutes of Health (U.S.); Phenylacetates; Piperidones; Treatment Failure; United States | 1999 |
Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans.
Topics: Administration, Oral; Adult; Female; Gas Chromatography-Mass Spectrometry; Glutamine; Humans; Male; Molecular Structure; Phenylacetates; Phenylbutyrates; Prodrugs | 2002 |
Participation: of phenylacetyl-adenylate in the enzymic synthesis of phenylacetylglutamine.
Topics: Biochemical Phenomena; Glutamine; Nucleosides; Nucleotides; Phenylacetates | 1957 |
Simultaneous LC-MS/MS determination of phenylbutyrate, phenylacetate benzoate and their corresponding metabolites phenylacetylglutamine and hippurate in blood and urine.
Topics: Benzoates; Biomarkers; Biotransformation; Calibration; Chromatography, Reverse-Phase; Glutamine; Hippurates; Humans; Hyperammonemia; Limit of Detection; Linear Models; Phenylacetates; Phenylbutyrates; Predictive Value of Tests; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Urea Cycle Disorders, Inborn | 2010 |
Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis.
Topics: Amino Acids; Ammonia; Animals; Brain; Disease Models, Animal; Evoked Potentials, Motor; Glutamine; Hepatic Encephalopathy; Male; Ornithine; Phenylacetates; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley | 2012 |
Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Glutamine; Glycerol; Hepatic Encephalopathy; Humans; Liver; Neoplasms; Phenylacetates; Phenylbutyrates; Randomized Controlled Trials as Topic; Urea Cycle Disorders, Inborn | 2013 |
Antineoplastons: when is enough enough?
Topics: Administration, Intravenous; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Evidence-Based Medicine; Glutamine; Humans; Neoplasms; Neurotoxicity Syndromes; Patient Safety; Phenylacetates; Quackery; Risk Assessment; Treatment Outcome | 2018 |
Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events.
Topics: Ammonia; Glutamine; Humans; Phenylacetates | 2021 |