phenylacetic acid has been researched along with glutamine in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.82) | 18.7374 |
| 1990's | 16 (47.06) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Smigel, K | 1 |
| Samid, D; Shack, S; Yeh, TJ | 1 |
| Brusilow, SW | 1 |
| Dubin, A; Javaid, JI; Mizock, BA; Poulos, A; Rackow, EC; Sabelli, HC | 1 |
| Brusilow, SW; Rajantie, J; Simell, O; Sipilä, I; Valle, DL | 1 |
| Figg, WD; Headlee, D; Lieberman, R; Myers, CE; Piscitelli, SC; Samid, D; Thibault, A; Tompkins, A | 1 |
| Chang, B; Han, G; Moore, T; Samid, D; Shack, S; Sidell, N; Wada, R | 1 |
| Burzyński, SR; Sołtysiak-Pawłuczuk, D | 1 |
| Cline, GW; Katz, LD; Magnusson, I; Rothman, DL; Shulman, GI | 1 |
| Cooper, MR; Figg, WD; Headlee, DJ; McCall, NA; Samid, D; Sartor, AO; Thibault, A; Tompkins, AC; Venzon, DJ; Weinberger, MS | 1 |
| Agarwal, KC; Beylot, M; Brunengraber, H; Soloviev, MV; Yang, D | 1 |
| Myers, CE; Samid, D; Shack, S | 1 |
| Agarwal, KC; Beylot, M; Brunengraber, H; David, F; Dugelay, S; Fernandez, CA; Hazey, JW; Levine, WC; Previs, SF; Rinaldo, P; Soloviev, MV; Yang, D | 1 |
| D'Alessio, DA; Dawson, EK; Mozzoli, MA; Owen, OE; Smalley, KJ | 1 |
| Jeffrey, FM; Jones, JG; Malloy, CR; Sherry, AD; Solomon, MA | 1 |
| Burzynski, SR | 1 |
| Beylot, M; Diraison, F; Krempf, M; Large, V; Maugeais, C | 1 |
| Baker, SD; Bowling, MK; Carducci, MA; Donehower, RC; Figg, WD; Gilbert, J; Grochow, L; Zabelina, Y | 1 |
| Bowling, MK; Carducci, MA; Chen, TL; Donehower, RC; Eisenberger, MA; Gilbert, J; Grochow, LB; Noe, D; Sinibaldi, V; Zabelina, Y | 1 |
| Brunengraber, H; Comte, B; Dahms, W; Kasumov, T; Kerr, D; Nissim, I; Pierce, BA; Puchowicz, MA; Scott, ME | 1 |
| Adamson, P; Aiken, A; Balis, F; Berg, S; Blaney, SM; Jakacki, R; Klenke, R; Murry, DJ; Packer, R; Serabe, BM; Thompson, P | 1 |
| MEISTER, A; MOLDAVE, K | 2 |
| Beliveau, M; Berry, SA; Diaz, GA; Dickinson, K; Gargosky, S; Lee, B; Marier, JF; Martinez, A; Mauney, J; Mian, A; Mokhtarani, M; Rhead, W; Scharschmidt, BF; Shchelochkov, O | 1 |
| Herebian, D; Laryea, MD; Mayatepek, E; Meissner, T | 1 |
| Arranz, JA; Córdoba, J; Oria, M; Raguer, N; Riudor, E; Romero-Giménez, J | 1 |
| Bart, S; Bartholomew, D; Bartley, J; Berquist, W; Berry, SA; Cederbaum, S; Coakley, DF; Diaz, GA; Dickinson, K; Dorrani, N; Feigenbaum, A; Gallagher, R; Harding, CO; Korson, MS; Kronn, D; Lee, B; Lemons, C; Lichter-Konecki, U; Longo, N; McCandless, SE; Merritt, JL; Mokhtarani, M; Moors, TL; Rhead, W; Scharschmidt, BF; Smith, W; Sreenath-Nagamani, S; Summar, M; Vockley, J; Zori, R | 1 |
| Bartley, J; Berquist, W; Berry, SA; Brown, RS; Coakley, D; Diaz, GA; Dickinson, K; Feigenbaum, A; Gallagher, R; Ghabril, M; Harding, C; Lee, B; Lemons, C; Lichter-Konecki, U; Longo, N; Mantry, P; McCandless, SE; Milikien, DA; Mokhtarani, M; Moors, T; Nagamani, SC; Norris, C; Rhead, W; Rockey, DC; Scharschmidt, BF; Schulze, A; Smith, W; Vierling, JM | 1 |
| Bellinger, A; Berry, GT; Cohen, DE; Frank, NY; Gershanik, EF; Goldberg, AD; Levy, BD; Lin, AP; Lynch, R; McFaline-Figueroa, JR; Merugumala, SK; O'Donnell-Luria, AH; Rohr, F; Samuels, MA; Simon, T; Tchekmedyian, V; Waisbren, SE | 1 |
| Akula, VP; Alcorn, D; Benitz, WE; Bernstein, JA; Berquist, WE; Blumenfeld, YJ; Castillo, RO; Concepcion, W; Cowan, TM; Cox, KL; Cusmano, K; Enns, GM; Esquivel, CO; Hintz, SR; Homeyer, M; Hudgins, L; Hurwitz, M; Lyell, DJ; Palma, JP; Schelley, S; Summar, ML; Wilnai, Y | 1 |
| Figg, WD | 1 |
| Berry, SA; Diaz, GA; Dong, M; Ficicioglu, C; Harding, CO; Holt, RJ; Lichter-Konecki, U; Longo, N; McCandless, SE; Perdok, R; Robinson, B; Smith, WE; Vinks, AA; Vockley, J; Zori, R | 1 |
| Mak, C; Poola, N; Tseng, J; Vilchez, RA; Wang, X | 1 |
7 trial(s) available for phenylacetic acid and glutamine
| Article | Year |
|---|---|
Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine.
Topics: Adult; Aged; Female; Glutamine; Humans; Male; Middle Aged; Models, Biological; Neoplasms; Phenylacetates; Phenylbutyrates | 1995 |
A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Administration Schedule; Female; Glioblastoma; Glutamine; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Neoplasms; Phenylacetates | 1994 |
A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Edema; Fatigue; Female; Glutamine; Humans; Hypocalcemia; Male; Middle Aged; Nausea; Neoplasms; Nervous System Diseases; Phenylacetates; Phenylbutyrates; Treatment Outcome; Vomiting | 2001 |
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Fatigue; Female; Glutamine; Humans; Hypokalemia; Infusions, Intravenous; Male; Metabolic Clearance Rate; Nausea; Neoplasms; Neutropenia; Patient Dropouts; Phenylacetates; Phenylbutyrates; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Uric Acid | 2001 |
Pharmacokinetics of phenylacetate administered as a 30-min infusion in children with refractory cancer.
Topics: Adolescent; Adult; Antineoplastic Agents; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Female; Glutamine; Half-Life; Humans; Infant; Infusions, Intravenous; Male; Models, Biological; Neoplasms; Phenylacetates; Spectrophotometry, Ultraviolet | 2003 |
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control.
Topics: Adult; Aged; Ammonia; Cross-Over Studies; Female; Glutamine; Glycerol; Humans; Male; Middle Aged; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn; Young Adult | 2010 |
Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders.
Topics: Adolescent; Adult; Ammonia; Biomarkers, Pharmacological; Child; Cross-Over Studies; Drug Administration Schedule; Female; Glutamine; Glycerol; Humans; Male; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn | 2012 |
27 other study(ies) available for phenylacetic acid and glutamine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Non-toxic drug being tested to treat cancer and anemias.
Topics: Anemia; Brain Neoplasms; Glutamine; Humans; Male; Phenylacetates; Phenylbutyrates; Prostatic Neoplasms | 1992 |
Interferon in combination with antitumourigenic phenyl derivatives: potentiation of IFN alpha activity in-vitro.
Topics: Cell Division; Cell Line; Drug Synergism; Glutamine; Humans; In Vitro Techniques; Interferon-alpha; Phenylacetates; Tumor Cells, Cultured | 1991 |
Phenylacetylglutamine may replace urea as a vehicle for waste nitrogen excretion.
Topics: Adolescent; Child; Child, Preschool; Female; Glutamine; Humans; Infant; Male; Metabolism, Inborn Errors; Nitrogen; Phenylacetates; Phenylbutyrates; Urea | 1991 |
Septic encephalopathy. Evidence for altered phenylalanine metabolism and comparison with hepatic encephalopathy.
Topics: Ammonia; Bacterial Infections; Brain Diseases, Metabolic; Glutamine; Hepatic Encephalopathy; Humans; Phenylacetates; Phenylalanine; Tryptophan; Tyrosine | 1990 |
Waste nitrogen excretion via amino acid acylation: benzoate and phenylacetate in lysinuric protein intolerance.
Topics: Acylation; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Benzoates; Benzoic Acid; Child; Child, Preschool; Creatinine; Glutamine; Hippurates; Humans; Lysine; Nitrogen; Orotic Acid; Phenylacetates; Urea | 1986 |
Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells.
Topics: Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Genes, myc; Glutamine; Humans; Immunoenzyme Techniques; Neurites; Neuroblastoma; Phenylacetates; Protein Prenylation; Proto-Oncogene Proteins c-myc; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1995 |
Cellular accumulation of antineoplaston AS21 in human hepatoma cells.
Topics: Anions; Antineoplastic Agents; Biological Transport; Carcinoma, Hepatocellular; Drug Combinations; Glutamine; Humans; In Vitro Techniques; Phenylacetates; Sodium; Temperature; Tumor Cells, Cultured | 1995 |
13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.
Topics: Acetaminophen; Adult; Carbon Isotopes; Citric Acid Cycle; Diabetes Mellitus, Type 1; Female; Glucose; Glucose Clamp Technique; Glutamine; Humans; Hyperglycemia; Liver; Liver Glycogen; Magnetic Resonance Spectroscopy; Male; Models, Biological; Phenylacetates; Pyruvate Dehydrogenase Complex; Uridine Diphosphate Glucose | 1994 |
Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry.
Topics: Adult; Citric Acid Cycle; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Glutamine; Humans; Liver; Molecular Probes; Phenylacetates; Phenylalanine; Sensitivity and Specificity | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phenotype; Phenylacetates; Prostatic Neoplasms; RNA, Neoplasm; Suramin; Transforming Growth Factor beta; Transplantation, Heterologous; Tumor Cells, Cultured | 1993 |
Noninvasive probing of citric acid cycle intermediates in primate liver with phenylacetylglutamine.
Topics: Animals; Carbon Isotopes; Citric Acid Cycle; Female; Glutamic Acid; Glutamine; Ketoglutaric Acids; Kidney; Lactic Acid; Liver; Macaca mulatta; Muscles; Phenylacetates | 1996 |
Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis.
Topics: Adult; Amino Acids; Antimetabolites, Antineoplastic; Body Composition; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Epinephrine; Female; Gluconeogenesis; Glutamine; Humans; Male; Middle Aged; Nitrogen; Nutritional Requirements; Obesity; Phenylacetates | 1998 |
13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen.
Topics: Acetaminophen; Adult; Blood Glucose; Carbon Isotopes; Female; Gluconeogenesis; Glucuronates; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Phenylacetates; Propionates; Pyruvates | 1998 |
Efficacy of antineoplastons A10 and AS2-1.
Topics: Antineoplastic Agents; Benzeneacetamides; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Glioma; Glutamine; Humans; National Institutes of Health (U.S.); Phenylacetates; Piperidones; Treatment Failure; United States | 1999 |
Noninvasive tracing of human liver metabolism: comparison of phenylacetate and apoB-100 to sample glutamine.
Topics: Adult; Apolipoprotein B-100; Apolipoproteins B; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glutamine; Hormones; Humans; Lactic Acid; Liver; Male; Middle Aged; Phenylacetates; Reference Values | 1999 |
Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans.
Topics: Administration, Oral; Adult; Female; Gas Chromatography-Mass Spectrometry; Glutamine; Humans; Male; Molecular Structure; Phenylacetates; Phenylbutyrates; Prodrugs | 2002 |
Enzymic acylation of glutamine by phenylacetic acid.
Topics: Acetates; Acylation; Glutamine; Phenylacetates | 1957 |
Participation: of phenylacetyl-adenylate in the enzymic synthesis of phenylacetylglutamine.
Topics: Biochemical Phenomena; Glutamine; Nucleosides; Nucleotides; Phenylacetates | 1957 |
Simultaneous LC-MS/MS determination of phenylbutyrate, phenylacetate benzoate and their corresponding metabolites phenylacetylglutamine and hippurate in blood and urine.
Topics: Benzoates; Biomarkers; Biotransformation; Calibration; Chromatography, Reverse-Phase; Glutamine; Hippurates; Humans; Hyperammonemia; Limit of Detection; Linear Models; Phenylacetates; Phenylbutyrates; Predictive Value of Tests; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Urea Cycle Disorders, Inborn | 2010 |
Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis.
Topics: Amino Acids; Ammonia; Animals; Brain; Disease Models, Animal; Evoked Potentials, Motor; Glutamine; Hepatic Encephalopathy; Male; Ornithine; Phenylacetates; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley | 2012 |
Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio.
Topics: Biomarkers; Drug-Related Side Effects and Adverse Reactions; Glutamine; Glycerol; Hepatic Encephalopathy; Humans; Liver; Neoplasms; Phenylacetates; Phenylbutyrates; Randomized Controlled Trials as Topic; Urea Cycle Disorders, Inborn | 2013 |
Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.
Topics: Brain; Coma; Female; Gastric Bypass; Glutamates; Glutamine; Humans; Hyperammonemia; Magnetic Resonance Spectroscopy; Middle Aged; Phenylacetates; Sodium Benzoate; Treatment Outcome | 2017 |
Prenatal treatment of ornithine transcarbamylase deficiency.
Topics: Ammonia; Drug Combinations; Female; Glutamine; Humans; Hyperammonemia; Infant, Newborn; Male; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Pregnancy; Prenatal Care; Prenatal Diagnosis; Sodium Benzoate; Treatment Outcome; Urea | 2018 |
Antineoplastons: when is enough enough?
Topics: Administration, Intravenous; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Evidence-Based Medicine; Glutamine; Humans; Neoplasms; Neurotoxicity Syndromes; Patient Safety; Phenylacetates; Quackery; Risk Assessment; Treatment Outcome | 2018 |
Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders.
Topics: Child; Child, Preschool; Female; Glutamine; Glycerol; Humans; Infant; Lipase; Male; Nitrogen; Phenylacetates; Phenylbutyrates; Prodrugs; Urea Cycle Disorders, Inborn | 2018 |
Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events.
Topics: Ammonia; Glutamine; Humans; Phenylacetates | 2021 |