phenylacetic acid has been researched along with ammonium hydroxide in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 9 (25.71) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 8 (22.86) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Holzknecht, RA; Mauer, SM; Summar, ML; Tuchman, M; Vnencak-Jones, CL | 1 |
| Hommes, FA; Koch, R; Pandya, AL; Williams, JC | 1 |
| Dubin, A; Javaid, JI; Mizock, BA; Poulos, A; Rackow, EC; Sabelli, HC | 1 |
| Oliver, RM; Raman, GV; Talbot, S | 1 |
| Brusilow, SW; Rajantie, J; Simell, O; Sipilä, I; Valle, DL | 1 |
| Batshaw, ML; Monahan, PS | 1 |
| Batshaw, ML; Coyle, JT; Hyman, SL; Mellits, ED; Quaskey, S; Qureshi, IA; Robinson, MB | 1 |
| Jones, G; Kulovich, S; Nyhan, WL; Petrowski, S; Reznik, V; Sweetman, L; Wolff, J | 1 |
| Marshall, L; Mendenhall, CL; Rouster, S; Weesner, R | 1 |
| Batshaw, M; Brusilow, SW; Burton, B; Danney, M; Levitsky, L; McKeethren, C; Roth, K; Waber, LJ; Ward, J | 1 |
| Berger, R; Mooy, P; Teijema, HL; Van de Bor, M; van Gelderen, HH; van Zoeren, D | 1 |
| Hayakawa, C; Kato, T; Maehara, M; Mizutani, N; Suzuki, S; Watanabe, K | 1 |
| Henry, BW; Lange, C; Matalon, R; Melnyk, AR; Zeller, WP | 1 |
| Klinger, RJ; Lo, WD; Sloan, HR; Sotos, JF | 1 |
| Bassett, SS; Brusilow, SW; Clissold, DB; Maestri, NE | 1 |
| del Rosario, M; Lauer, SJ; Werlin, SL | 1 |
| Thoene, JG | 1 |
| Berry, GT; Bridges, ND; Clancy, RR; Kaplan, P; Lichtenstein, GR; Nathanson, KL; Spray, TL | 1 |
| Barletta, GM; Bunchman, TE; Crumb, TL; Gardner, JJ; McBryde, KD; Winters, JW | 1 |
| Davies, NA; Hodges, SJ; Jalan, R; Wright, G | 1 |
| Berry, GT; Berry, SA; Brusilow, SW; Enns, GM; Hamosh, A; Rhead, WJ | 1 |
| Guliye, AY; Wallace, RJ | 1 |
| Cobos, MJ; Fuskevåg, OM; Jalan, R; Kalstad, T; Kristiansen, RG; Maehre, H; Revhaug, A; Rose, CF; Ytrebø, LM | 1 |
| Beliveau, M; Berry, SA; Diaz, GA; Dickinson, K; Gargosky, S; Lee, B; Marier, JF; Martinez, A; Mauney, J; Mian, A; Mokhtarani, M; Rhead, W; Scharschmidt, BF; Shchelochkov, O | 1 |
| Arranz, JA; Córdoba, J; Oria, M; Raguer, N; Riudor, E; Romero-Giménez, J | 1 |
| Balasubramaniyan, V; Davies, NA; Habtesion, A; Jalan, R; Mookerjee, RP; Sharifi, Y; Sharma, V; Wright, G | 1 |
| Bart, S; Bartholomew, D; Bartley, J; Berquist, W; Berry, SA; Cederbaum, S; Coakley, DF; Diaz, GA; Dickinson, K; Dorrani, N; Feigenbaum, A; Gallagher, R; Harding, CO; Korson, MS; Kronn, D; Lee, B; Lemons, C; Lichter-Konecki, U; Longo, N; McCandless, SE; Merritt, JL; Mokhtarani, M; Moors, TL; Rhead, W; Scharschmidt, BF; Smith, W; Sreenath-Nagamani, S; Summar, M; Vockley, J; Zori, R | 1 |
| Bain, KB; Byers, DE; Chen, C; Hachem, RR; Iuppa, JA; Patterson, GA; Trulock, EP; Witt, CA; Yusen, RD | 1 |
| de Koning, L; Gifford, JL; Khan, A; Orton, DJ; Seiden-Long, I | 1 |
| Akula, VP; Alcorn, D; Benitz, WE; Bernstein, JA; Berquist, WE; Blumenfeld, YJ; Castillo, RO; Concepcion, W; Cowan, TM; Cox, KL; Cusmano, K; Enns, GM; Esquivel, CO; Hintz, SR; Homeyer, M; Hudgins, L; Hurwitz, M; Lyell, DJ; Palma, JP; Schelley, S; Summar, ML; Wilnai, Y | 1 |
| Brossier, D; Goyer, I; Jouvet, P; Marquis, C; Mitchell, G; Ozanne, B; Ziani, L | 1 |
| Ah Mew, N; Bannick, AA; Berry, SA; Canavan, C; Conway, RL; Diaz, GA; Hainline, B; Inbar-Feigenberg, M; Kok, T; Lichter-Konecki, U; Longo, N; McCandless, SE; Porter, MH; Schulze, A; Vescio, T; Zori, R | 1 |
| Mak, C; Poola, N; Tseng, J; Vilchez, RA; Wang, X | 1 |
| Vilchez, RA; Wang, X | 1 |
| Bajaj, JS; Bukofzer, S; Devarakonda, KR; Jamil, K; Potthoff, A; Pyrsopoulos, N; Rahimi, RS; Ram Bhamidimarri, K; Safadi, R; Thabut, D; Wang, L | 1 |
3 review(s) available for phenylacetic acid and ammonium hydroxide
| Article | Year |
|---|---|
Treatment of urea cycle disorders.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Benzoates; Benzoic Acid; Dietary Proteins; Humans; Nitrogen; Phenylacetates; Prognosis | 1987 |
Late clinical presentation of partial carbamyl phosphate synthetase I deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Biopsy; Body Height; Body Weight; Carbamoyl-Phosphate Synthase (Ammonia); Coma; Diagnosis, Differential; Dietary Proteins; Growth Disorders; Humans; Male; Pediatrics; Phenylacetates; Renal Dialysis | 1993 |
Treatment of urea cycle disorders.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Antimetabolites; Child, Preschool; Drug Combinations; Humans; Infant; Infant, Newborn; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Sodium Benzoate; Urea | 1999 |
6 trial(s) available for phenylacetic acid and ammonium hydroxide
| Article | Year |
|---|---|
A new therapy for portal systemic encephalopathy.
Topics: Aged; Ammonia; Benzoates; Benzoic Acid; Double-Blind Method; Drug Evaluation; Hepatic Encephalopathy; Humans; Male; Middle Aged; Phenylacetates; Random Allocation | 1986 |
Long-term treatment of girls with ornithine transcarbamylase deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Brain Diseases; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Intelligence; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Phenylbutyrates; Treatment Outcome | 1996 |
Survival after treatment with phenylacetate and benzoate for urea-cycle disorders.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Amino Acid Metabolism, Inborn Errors; Ammonia; Carbamoyl-Phosphate Synthase I Deficiency Disease; Child; Child, Preschool; Citrullinemia; Female; Humans; Hyperammonemia; Infant; Infant, Newborn; Male; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Sodium Benzoate; Survival Analysis; Urea | 2007 |
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control.
Topics: Adult; Aged; Ammonia; Cross-Over Studies; Female; Glutamine; Glycerol; Humans; Male; Middle Aged; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn; Young Adult | 2010 |
Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders.
Topics: Adolescent; Adult; Ammonia; Biomarkers, Pharmacological; Child; Cross-Over Studies; Drug Administration Schedule; Female; Glutamine; Glycerol; Humans; Male; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn | 2012 |
Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes.
Topics: Adult; Ammonia; Hepatic Encephalopathy; Humans; Ornithine; Phenylacetates | 2022 |
26 other study(ies) available for phenylacetic acid and ammonium hydroxide
| Article | Year |
|---|---|
Prospective versus clinical diagnosis and therapy of acute neonatal hyperammonaemia in two sisters with carbamyl phosphate synthetase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Female; Humans; Infant, Newborn; Kinetics; Pedigree; Peritoneal Dialysis; Phenylacetates; Polymorphism, Restriction Fragment Length; Pregnancy; Prenatal Diagnosis; Prospective Studies; Renal Dialysis | 1992 |
N-acetylglutamate synthetase deficiency: clinical and laboratory observations.
Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Benzoates; Benzoic Acid; Citrulline; Dietary Proteins; Humans; Infant; Infant, Newborn; Liver; Male; Phenylacetates | 1991 |
Septic encephalopathy. Evidence for altered phenylalanine metabolism and comparison with hepatic encephalopathy.
Topics: Ammonia; Bacterial Infections; Brain Diseases, Metabolic; Glutamine; Hepatic Encephalopathy; Humans; Phenylacetates; Phenylalanine; Tryptophan; Tyrosine | 1990 |
Hyperammonaemic coma in ureterosigmoid urinary diversion.
Topics: Amino Acids; Ammonia; Benzoates; Benzoic Acid; Colon, Sigmoid; Coma; Female; Humans; Middle Aged; Phenylacetates; Urinary Diversion | 1989 |
Waste nitrogen excretion via amino acid acylation: benzoate and phenylacetate in lysinuric protein intolerance.
Topics: Acylation; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Benzoates; Benzoic Acid; Child; Child, Preschool; Creatinine; Glutamine; Hippurates; Humans; Lysine; Nitrogen; Orotic Acid; Phenylacetates; Urea | 1986 |
Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse.
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Benzoates; Benzoic Acid; Brain; Child; Citrulline; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Mutant Strains; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Serotonin | 1988 |
Pharmacologic amino acid acylation in the acute hyperammonemia of propionic acidemia.
Topics: Acylation; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Humans; Infant; Male; Phenylacetates; Propionates; Renal Dialysis | 1987 |
Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinate Synthase; Benzoates; Benzoic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Drug Administration Schedule; Humans; Infant; Injections, Intravenous; Male; Ornithine Carbamoyltransferase Deficiency Disease; Parenteral Nutrition, Total; Phenylacetates; Renal Dialysis; Urea | 1984 |
Successful treatment of severe carbamyl phosphate synthetase I deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Benzoates; Benzoic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Dietary Proteins; Female; Humans; Infant, Newborn; Ligases; Phenylacetates | 1984 |
Hyperargininemia: clinical course and treatment with sodium benzoate and phenylacetic acid.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Arginine; Benzoates; Benzoic Acid; Child, Preschool; Dietary Proteins; Humans; Male; Phenylacetates | 1983 |
Prospective management of a child with neonatal citrullinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinate Synthase; Benzoates; Benzoic Acid; Child Development; Child, Preschool; Citrulline; Female; Humans; Infant; Infant, Newborn; Phenylacetates | 1993 |
Hyperammonemic encephalopathy after chemotherapy. Survival after treatment with sodium benzoate and sodium phenylacetate.
Topics: Adolescent; Ammonia; Antimetabolites; Benzoates; Benzoic Acid; Brain Diseases; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Phenylacetates | 1997 |
Successful use of alternate waste nitrogen agents and hemodialysis in a patient with hyperammonemic coma after heart-lung transplantation.
Topics: Adult; Amino Acids; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Coma; Edema; Female; Heart-Lung Transplantation; Humans; Phenylacetates; Renal Dialysis | 1999 |
Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration.
Topics: Ammonia; Hemofiltration; Humans; Hyperammonemia; Infant, Newborn; Phenylacetates; Renal Dialysis; Sodium Benzoate | 2007 |
L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy.
Topics: Ammonia; Drug Therapy, Combination; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver; Models, Biological; Muscle, Skeletal; Ornithine; Phenylacetates | 2007 |
Effects of aromatic amino acids, phenylacetate and phenylpropionate on fermentation of xylan by the rumen anaerobic fungi, Neocallimastix frontalis and Piromyces communis.
Topics: Amino Acids, Aromatic; Ammonia; Animals; Culture Media; Fatty Acids, Volatile; Fermentation; Neocallimastix; Phenylacetates; Phenylpropionates; Piromyces; Rumen; Xylans | 2007 |
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.
Topics: Ammonia; Animals; Arteries; Brain; Drug Combinations; Extracellular Space; Intracranial Hypertension; Liver Failure, Acute; Ornithine; Phenylacetates; Swine | 2009 |
Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis.
Topics: Amino Acids; Ammonia; Animals; Brain; Disease Models, Animal; Evoked Potentials, Motor; Glutamine; Hepatic Encephalopathy; Male; Ornithine; Phenylacetates; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley | 2012 |
Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats.
Topics: Amidohydrolases; Ammonia; Animals; Arginine; Bile Ducts; Brain; Ligation; Liver Cirrhosis; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Ornithine; Phenylacetates; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2012 |
Hyperammonemia Syndrome After Lung Transplantation: A Single Center Experience.
Topics: Aged; Ammonia; Arginine; Biomarkers; Carnitine; Combined Modality Therapy; Decontamination; Female; Humans; Hyperammonemia; Immunosuppressive Agents; Lung Transplantation; Male; Middle Aged; Missouri; Phenylacetates; Protective Agents; Renal Dialysis; Retrospective Studies; Sodium Benzoate; Syndrome; Time Factors; Treatment Outcome; Up-Regulation | 2016 |
Critically High Plasma Ammonia in an Adolescent Girl.
Topics: Ammonia; Arginine; Child; Clinical Chemistry Tests; Diagnostic Errors; Fatigue; Female; Fever; Headache; Humans; Hyperammonemia; Phenylacetates; Reference Values; Sodium Benzoate | 2016 |
Prenatal treatment of ornithine transcarbamylase deficiency.
Topics: Ammonia; Drug Combinations; Female; Glutamine; Humans; Hyperammonemia; Infant, Newborn; Male; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenylacetates; Pregnancy; Prenatal Care; Prenatal Diagnosis; Sodium Benzoate; Treatment Outcome; Urea | 2018 |
Influence of implementing a protocol for an intravenously administered ammonia scavenger on the management of acute hyperammonemia in a pediatric intensive care unit.
Topics: Acute Disease; Ammonia; Canada; Child; Child, Preschool; Female; Humans; Hyperammonemia; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care Units, Pediatric; Male; Phenylacetates; Retrospective Studies; Sodium Benzoate | 2019 |
Glycerol phenylbutyrate efficacy and safety from an open label study in pediatric patients under 2 months of age with urea cycle disorders.
Topics: Age of Onset; Ammonia; Child, Preschool; Female; Glycerol; Humans; Hyperammonemia; Infant; Infant, Newborn; Male; Pediatrics; Phenylacetates; Phenylbutyrates; Renal Dialysis; Urea Cycle Disorders, Inborn | 2021 |
Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events.
Topics: Ammonia; Glutamine; Humans; Phenylacetates | 2021 |
Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid.
Topics: Adult; Ammonia; Clinical Trials as Topic; Hepatic Encephalopathy; Humans; Ornithine; Phenylacetates | 2022 |