Page last updated: 2024-08-23

phenyl acetate and ml-3000

phenyl acetate has been researched along with ml-3000 in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (16.07)	18.2507
2000's	47 (83.93)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carter, L; Laufer, S; McKnight, W; Tries, S; Wallace, JL	1
Algate, DR; Atterson, PR; Augustin, J; Beard, DJ; Jobling, CM; Laufer, S; Munt, PL; Tries, S	1
Deigner, HP; Freyberg, CE; Laufer, S	1
Augustin, J; Heidemann, A; Laufer, S; Tries, S	1
Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Laufer, S; Munt, PL; Tries, S	1
Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S	1
Augustin, J; Dannhardt, G; Laufer, S; Tries, S	1
Claus, R; Deigner, HP; Fyrnys, B; Wolf, G	1
Abraham, WM; Laufer, S; Tries, S	1
Gay, RE; Gay, S; Laufer, S; Neidhart, M; Pataky, F; Tries, S	1
Fernandes, JC; Jolicoeur, FC; Jovanovic, DV; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P; Tries, S	1
Breddin, HK; Laufer, S; Radziwon, P; Tries, S	1
Laufer, S; Neupert, W; Tries, S	1
Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP	1
Boileau, C; Jouzeau, JY; Laufer, S; Martel-Pelletier, J; Moldovan, F; Netter, P; Pelletier, JP; Tries, S	1
Cerletti, C; Dell'Elba, G; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Martelli, N; Pecce, R; Rotondo, S	1
Barbanti, M; de Lima, OM; Distrutti, E; Fiorucci, S; Mencarelli, A; Morelli, A; Palazzini, E; Romano, M; Wallace, JL	1
Hawkey, CJ; Skelly, MM	1
Laufer, S	1
Evans, R	1
Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL	1
Cicuttini, F; Ding, C	1
Celotti, F; Durand, T	1
Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP	1
Bannwarth, B	1
Brune, K	1
Alvaro-Gracia, JM	1
Boileau, C; Boily, M; Brunet, J; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P	1
Goldenring, JR; Gupta, S; Hammond, CE; Smolka, AJ	1
Cerletti, C; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Rotondo, S	1
Bias, P; Buchner, A; Klesser, B; Laufer, S	1
Boileau, C; Fahmi, H; Laufer, S; Lavigne, M; Martel-Pelletier, J; Pelletier, JP; Tardif, G	1
Daminet, S; Fernandes, J; Martel-Pelletier, J; Moreau, M; Pelletier, JP	1
Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P	1
Kulkarni, SK; Patil, CS; Singh, VP	2
Naveau, B	1
Albrecht, W; Dannhardt, G; Eriksson, EE; Laufer, S; Lindbom, L; Soehnlein, O; Ulbrich, H; Xie, X	1
Cicero, AF; Derosa, G; Gaddi, A	1
Boileau, C; Boily, M; Brunet, J; Geng, C; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P	1
Boileau, C; Brunet, J; Laufer, S; Martel-Pelletier, J; Moreau, M; Pelletier, JP	1
Cerletti, C; Dell'Elba, G; Evangelista, V; Manarini, S; Rotondo, S	1
Egido, J; Gómez-Gerique, JA; Gómez-Hernández, A; González, A; Ortega, L; Sánchez-Galán, E; Tuñón, J; Vidal, C	1
Arderiu, G; Escolar, G; Hernandez, MR; Pedreño, J; Pino, M; Salas, E; Serradell, M; Tonda, R	1
Hampton, T	1
Kulkarni, SK; Singh, VP	1
Doucet, M; Lussier, B; Martel-Pelletier, J; Moreau, M; Pelletier, JP; Vincent, G	1
Gay, RE; Gay, S; Kurowska-Stolarska, M; Laufer, S; Michel, BA; Neidhart, M; Ospelt, C	1
Dodt, G; Fischer, L; Franke, L; Hornig, M; Meindl, N; Pergola, C; Schneider, G; Steinhilber, D; Tanrikulu, Y; Werz, O	1
Martel-Pelletier, J; Pelletier, JP	1
Coruzzi, G; Spaggiari, S; Venturi, N	1
Bartolini, G; Bonafè, M; Brighenti, E; Ferreri, C; Guarnieri, T; Laufer, S; Manara, S; Marini, M; Tavolari, S; Tomasi, V	1
Cicero, AF; Laghi, L	1
Albrecht, W; Laufer, S; Nussler, AK; Unger, A	1

Reviews

12 review(s) available for phenyl acetate and ml-3000

Article	Year
ML 3000. Drugs in R&D, 2002, Volume: 3, Issue:3 Topics: Acetates; Animals; Clinical Trials as Topic; Drug Industry; Humans; Lung Diseases, Obstructive; Pyrroles; Rheumatic Diseases	2002
COX-LOX inhibition: current evidence for an emerging new therapy. International journal of clinical practice, 2003, Volume: 57, Issue:4 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Dogs; Humans; Intestinal Mucosa; Leukotrienes; Lipoxygenase Inhibitors; Models, Animal; Peptic Ulcer; Prostaglandins; Pyrroles; Rats; Sheep	2003
Licofelone (Merckle). IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:8 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Structure-Activity Relationship	2003
The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy. Prostaglandins & other lipid mediators, 2003, Volume: 71, Issue:3-4 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cardiovascular System; Clinical Trials, Phase III as Topic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Intestinal Mucosa; Isoenzymes; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrroles	2003
Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy? Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:1 Topics: Acetates; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Digestive System; Eicosanoids; Humans; Kidney Function Tests; Lipoxygenase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles; Randomized Controlled Trials as Topic	2004
Safety of anti-inflammatory treatment--new ways of thinking. Rheumatology (Oxford, England), 2004, Volume: 43 Suppl 1 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Gastrointestinal Diseases; Humans; Isoenzymes; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles	2004
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford, England), 2004, Volume: 43 Suppl 1 Topics: Acetates; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Combinations; Gastrointestinal Diseases; Humans; Isoenzymes; Lipoxygenase Inhibitors; Long-Term Care; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrroles; Sulfonamides	2004
Combined lipoxygenase/cyclo-oxygenase inhibition in the elderly: the example of licofelone. Drugs & aging, 2005, Volume: 22, Issue:5 Topics: Acetates; Aged; Animals; Clinical Trials as Topic; Comorbidity; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles	2005
Licofelone--a novel analgesic and anti-inflammatory agent. Current topics in medicinal chemistry, 2007, Volume: 7, Issue:3 Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles	2007
DMOAD developments: present and future. Bulletin of the NYU hospital for joint diseases, 2007, Volume: 65, Issue:3 Topics: Acetates; Anthraquinones; Antirheumatic Agents; Chondroitin; Clinical Trials as Topic; Diphosphonates; Disease Progression; Doxycycline; Glucosamine; Humans; Hyaluronic Acid; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles; Risk Factors	2007
Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond. Acta bio-medica : Atenei Parmensis, 2007, Volume: 78, Issue:2 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Colon; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Humans; Hydrogen Sulfide; Lipoxins; Lipoxygenase Inhibitors; Nitric Oxide; Nitric Oxide Donors; Protein Isoforms; Pyrroles; Safety	2007
Activity and potential role of licofelone in the management of osteoarthritis. Clinical interventions in aging, 2007, Volume: 2, Issue:1 Topics: Acetates; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Treatment Outcome	2007

Trials

3 trial(s) available for phenyl acetate and ml-3000

Article	Year
The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial. The American journal of gastroenterology, 2004, Volume: 99, Issue:4 Topics: Acetates; Adult; Cyclooxygenase Inhibitors; Duodenoscopy; Duodenum; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Naproxen; Peptic Ulcer; Pyrroles	2004
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs. Journal of veterinary pharmacology and therapeutics, 2005, Volume: 28, Issue:1 Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dogs; Double-Blind Method; Duodenoscopy; Duodenum; Gastroscopy; Lactones; Lipoxygenase Inhibitors; Pyrroles; Stomach; Sulfones; Treatment Outcome	2005
Efficacy of licofelone in dogs with clinical osteoarthritis. The Veterinary record, 2007, Apr-28, Volume: 160, Issue:17 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Double-Blind Method; Female; Gait; Lameness, Animal; Male; Osteoarthritis; Pyrroles	2007

Other Studies

41 other study(ies) available for phenyl acetate and ml-3000

Article	Year
ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury. European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cyclooxygenase Inhibitors; Gastric Mucosa; Leukocytes; Lipoxygenase Inhibitors; Male; Prostaglandins; Pyrroles; Rabbits; Rats; Rats, Wistar; Stomach Ulcer	1994
General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals. Arzneimittel-Forschung, 1995, Volume: 45, Issue:2 Topics: Acetates; Animals; Behavior, Animal; Cats; Central Nervous System; Digestive System; Dogs; Female; Guinea Pigs; Hemodynamics; Kidney; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Pyrroles; Rats; Rats, Wistar; Respiratory System	1995
Distribution and excretion of [14C]-labelled [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5- yl]- [2'-14C]-acetic acid in rats. Arzneimittel-Forschung, 1995, Volume: 45, Issue:3 Topics: Acetates; Animals; Autoradiography; Chromatography, High Pressure Liquid; Feces; Female; Isotope Labeling; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Pyrroles; Rats; Rats, Inbred Strains; Tissue Distribution	1995
Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6- (4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittel-Forschung, 1995, Volume: 45, Issue:4 Topics: Acetates; Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Repair; Female; Lipoxygenase Inhibitors; Male; Mutagenicity Tests; Mutagens; Pyrroles; Rats; Rats, Wistar; Salmonella typhimurium	1995
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12 Topics: Acetates; Animals; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pyrroles; Rats; Rats, Wistar	1994
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittel-Forschung, 1995, Volume: 45, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar	1995
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase. Arzneimittel-Forschung, 1994, Volume: 44, Issue:5 Topics: Acetates; Animals; Arachidonic Acid; Arthritis, Experimental; Benzoquinones; Blood Coagulation; Bronchoconstriction; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Guinea Pigs; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Pain Measurement; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Yeast, Dried	1994
Oxidized low density lipoprotein stimulates protein kinase C (PKC) activity and expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 cells. Advances in experimental medicine and biology, 1997, Volume: 407 Topics: Acetates; Animals; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Induction; Indomethacin; Isoenzymes; Leukemia P388; Lipoproteins, LDL; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neoplasm Proteins; Nitrobenzenes; Oxidation-Reduction; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Serum Albumin, Bovine; Sulfonamides	1997
The effects of ML 3000 on antigen-induced responses in sheep. Pulmonary pharmacology & therapeutics, 1997, Volume: 10, Issue:3 Topics: Acetates; Aerosols; Animals; Antigens; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclooxygenase Inhibitors; Female; Hypersensitivity, Delayed; Lipoxygenase Inhibitors; Pyrroles; Sheep	1997
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis. The Journal of rheumatology, 2001, Volume: 28, Issue:9 Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Lipoxygenase Inhibitors; Probability; Prostaglandin-Endoperoxide Synthases; Pyrroles; Range of Motion, Articular; Rats; Rats, Inbred Lew; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome	2001
[Double blockade should protect the stomach. New approach to rheumatism]. MMW Fortschritte der Medizin, 2001, Sep-20, Volume: 143, Issue:38 Topics: Acetates; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Stomach Ulcer	2001
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis. Arthritis and rheumatism, 2001, Volume: 44, Issue:10 Topics: Acetates; Animals; Collagenases; Cyclooxygenase Inhibitors; Dogs; Interleukin-1; Lipoxygenase; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles	2001
Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibrinolytic Agents; Lipoxygenase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar	2002
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:3 Topics: Acetates; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Humans; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach; Thromboxane B2	2002
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition. Arthritis and rheumatism, 2002, Volume: 46, Issue:7 Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides	2002
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. The Journal of rheumatology, 2002, Volume: 29, Issue:7 Topics: Acetates; Administration, Oral; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 1; Nitric Oxide Synthase; Osteoarthritis; Probability; Pyrroles; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric	2002
Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function. European journal of pharmacology, 2002, Oct-18, Volume: 453, Issue:1 Topics: Acetates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Neutrophils; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Pyrroles	2002
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:9 Topics: Acetates; Acetylation; Adaptation, Physiological; Animals; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Hydroxyeicosatetraenoic Acids; Isoenzymes; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats	2003
International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium. Expert opinion on investigational drugs, 2003, Volume: 12, Issue:7 Topics: Acetates; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nitric Oxide Donors; Osteoarthritis; Pyrroles	2003
Anti arthritic drugs--SMi conference: dual inhibitors. 28-29 April 2003, London, UK. IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:6 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis; Clinical Trials as Topic; Complement Activation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha	2003
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin. British journal of pharmacology, 2003, Volume: 139, Issue:7 Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation	2003
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:1 Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator	2004
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone, 2004, Volume: 34, Issue:3 Topics: Acetates; Animals; Bone Resorption; Cathepsin K; Cathepsins; Collagenases; Dogs; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles	2004
Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC gastroenterology, 2004, Feb-10, Volume: 4 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Enzyme Inhibitors; Gastric Mucosa; Humans; Hydrochloric Acid; Interleukin-1; Interleukin-8; Omeprazole; Parietal Cells, Gastric; Proton Pump Inhibitors; Pyrroles; Rabbits	2004
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation. European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3 Topics: Acetates; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Humans; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinolines; Thrombin; Thromboxane B2	2004
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway. Annals of the rheumatic diseases, 2005, Volume: 64, Issue:6 Topics: Acetates; Aged; Cells, Cultured; Chondrocytes; Collagenases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Interleukin-1; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Middle Aged; Osteoarthritis, Knee; Promoter Regions, Genetic; Pyrroles; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic	2005
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. The Journal of rheumatology, 2005, Volume: 32, Issue:4 Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane	2005
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. Indian journal of experimental biology, 2005, Volume: 43, Issue:3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indomethacin; Inflammation; Leukotriene B4; Lipid Peroxidation; Male; Mesentery; Mice; Neutrophils; Pyrroles; Rats; Stomach Ulcer; Time Factors	2005
Dual inhibition of cyclo-oxygenases and 5-lipoxygenase: a novel therapeutic approach to inflammation? Joint bone spine, 2005, Volume: 72, Issue:3 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles	2005
Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow. Biochemical pharmacology, 2005, Jul-01, Volume: 70, Issue:1 Topics: Acetates; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Leukocytes; Lipoxygenase Inhibitors; Pyrroles; RNA, Messenger	2005
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis research & therapy, 2005, Volume: 7, Issue:5 Topics: Acetates; ADAM Proteins; ADAMTS4 Protein; Animals; Anterior Cruciate Ligament; Arachidonate 5-Lipoxygenase; Cathepsin K; Cathepsins; Collagenases; Cyclooxygenase Inhibitors; Dogs; Down-Regulation; Drug Evaluation; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Lipoxygenase Inhibitors; Matrix Metalloproteinase 13; Osteoarthritis; Procollagen N-Endopeptidase; Pyrroles; RNA, Messenger	2005
Anti-inflammatory effect of licofelone against various inflammatory challenges. Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch	2006
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. The Journal of rheumatology, 2006, Volume: 33, Issue:6 Topics: Acetates; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Collagenases; Disease Models, Animal; Disease Progression; Dogs; Enzyme Inhibitors; Metalloproteases; Osteoarthritis, Knee; Pyrroles; Stifle	2006
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit. European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3 Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors	2006
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1 Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima	2007
Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity. Journal of cardiovascular medicine (Hagerstown, Md.), 2006, Volume: 7, Issue:12 Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hemostasis; Humans; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrroles; Rabbits	2006
Arthritis clinical trial results revealed. JAMA, 2007, Jan-03, Volume: 297, Issue:1 Topics: Acetates; Antirheumatic Agents; Arthritis, Rheumatoid; Chondroitin Sulfates; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Osteoarthritis; Piperidines; Pyrimidines; Pyrroles	2007
The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. Annals of the rheumatic diseases, 2008, Volume: 67, Issue:4 Topics: Acetates; Arthritis, Rheumatoid; Cells, Cultured; Chemokines, CXC; Cyclooxygenase Inhibitors; Down-Regulation; Fibroblasts; Humans; Ligands; Lipoxygenase Inhibitors; Polymerase Chain Reaction; Pyrroles; Receptors, CXCR3; RNA, Messenger; Synovial Membrane	2008
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products. British journal of pharmacology, 2007, Volume: 152, Issue:4 Topics: 5-Lipoxygenase-Activating Proteins; Acetates; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arsenites; Bridged Bicyclo Compounds; Calcimycin; Calcium; Carrier Proteins; Cell-Free System; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Molecular Structure; Neutrophils; Nuclear Envelope; Pyrroles; Quinolines; Sodium Compounds; Transfection	2007
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis, 2008, Volume: 29, Issue:2 Topics: Acetates; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Gene Expression Regulation, Neoplastic; Humans; Lipoxygenase Inhibitors; Membrane Potential, Mitochondrial; Mitochondria; Prostaglandin-Endoperoxide Synthases; Pyrroles	2008
In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Acetates; Animals; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cyclopropanes; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Hepatocytes; Humans; Lipoxygenase Inhibitors; Macaca fascicularis; Mice; Mice, Inbred Strains; Microsomes; Paclitaxel; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfides	2008