phenyl acetate has been researched along with gemfibrozil in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allen, CM; Henry, A; Stacpoole, PW | 1 |
| Hirakawa, T; Imaizumi, K; Nagao, K; Nakayama, M; Sakono, M | 1 |
| Hashimoto, F; Hayashi, H; Taira, S | 1 |
| Hashimoto, F; Hayashi, H; Ikeda, M; Shiota, Y | 1 |
| Backman, JT; Filppula, A; Karonen, T; Laitila, J; Neuvonen, PJ; Niemi, M | 1 |
| Backman, JT; Karonen, T; Neuvonen, PJ | 1 |
| Aatsinki, SM; Hokkanen, J; Lassila, T; Mattila, S; Tolonen, A; Turpeinen, M | 1 |
| Bi, Y; El-Kattan, AF; Eng, H; Kalgutkar, AS; Kimoto, E; Lin, J; Rodrigues, AD; Scialis, R; Tremaine, LM; Varma, MV | 1 |
| Boehler, M; Bruderer, S; Dingemanse, J; Halabi, A; Petersen-Sylla, M; Remeňová, T | 1 |
3 trial(s) available for phenyl acetate and gemfibrozil
| Article | Year |
|---|---|
Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP2C8; DNA; Drug Interactions; Female; Gemfibrozil; Genotype; Glucuronides; Half-Life; Humans; Hypolipidemic Agents; Leukotriene Antagonists; Male; Mass Spectrometry; Microsomes, Liver; Quinolines; Sulfides; Young Adult | 2010 |
CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast.
Topics: 14-alpha Demethylase Inhibitors; Acetates; Adult; Anti-Asthmatic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Interactions; Female; Gemfibrozil; Humans; Hypolipidemic Agents; Itraconazole; Male; Quinolines; Sulfides; Young Adult | 2012 |
Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects.
Topics: Acetamides; Acetates; Activation, Metabolic; Adolescent; Adult; Antihypertensive Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Gemfibrozil; Germany; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Prodrugs; Pyrazines; Rifampin; Risk Assessment; Young Adult | 2017 |
6 other study(ies) available for phenyl acetate and gemfibrozil
| Article | Year |
|---|---|
Fibric acid derivatives: effects on the synthesis of isoprenoid lipids in cultured human lymphocytes.
Topics: Acetates; Cell Division; Cholesterol; Clofibrate; Dolichols; Gemfibrozil; Humans; Lymphocytes; Mevalonic Acid; Tumor Cells, Cultured; Ubiquinone | 1992 |
Effect of gemfibrozil on triacylglycerol synthesis and secretion by liver and lipoprotein lipase activity in adipose tissue of rats.
Topics: Acetates; Adipose Tissue; Animals; Apolipoproteins B; Carbon Radioisotopes; Dose-Response Relationship, Drug; Gemfibrozil; Hypolipidemic Agents; Lipid Metabolism; Lipids; Lipoprotein Lipase; Liver; Male; Oleic Acid; Rats; Rats, Sprague-Dawley; Triglycerides | 1999 |
Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes.
Topics: Acetates; Acyl Coenzyme A; Animals; Cholesterol; Clofibric Acid; Dolichols; Gemfibrozil; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Lipid Metabolism; Lipids; Liver; Male; Mevalonic Acid; Peroxisomes; Rats; Ubiquinone | 2000 |
Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver.
Topics: Acetates; Animals; Carbon Radioisotopes; Cholesterol; Clofibrate; Dolichol Phosphates; Dolichols; Gemfibrozil; Liver; Male; Mevalonic Acid; Peroxisome Proliferators; Polyisoprenyl Phosphates; Rats; Rats, Wistar; Sesquiterpenes; Tritium | 2003 |
Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated.
Topics: Acetates; Acyl Coenzyme A; Acylation; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cyclopropanes; Gemfibrozil; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Quinolines; Sulfides; Tolmetin | 2015 |
Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.
Topics: Acetates; Animals; Clarithromycin; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Gemfibrozil; Haplorhini; Hepatocytes; Liver; Liver-Specific Organic Anion Transporter 1; Models, Biological; Nucleic Acid Synthesis Inhibitors; Organic Anion Transporters; Quinolines; Rats; Rifampin; Sulfides | 2017 |