Page last updated: 2024-08-23

phenyl acetate and gc 1 compound

phenyl acetate has been researched along with gc 1 compound in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	29 (37.18)	29.6817
2010's	36 (46.15)	24.3611
2020's	13 (16.67)	2.80

Authors

Authors	Studies
Baxter, JD; Chiellini, G; Dillmann, WH; Gloss, B; Grover, GJ; Scanlan, TS; Swanson, E; Trost, SU; Volodarsky, T; Wang-Iverson, DB; Zhang, H	1
Apriletti, JW; Baxter, JD; Cunha Lima, ST; Fletterick, RJ; Huber, BR; Kelly, A; Scanlan, TS; Shiau, AK; Wagner, RL; West, BL	1
Bianco, AC; Brent, GA; Carvalho, SD; Chiellini, G; Ribeiro, MO; Scanlan, TS; Schultz, JJ	1
Apriletti, JW; Baxter, JD; Scanlan, TS; Yoshihara, HA	2
Apriletti, JW; Baxter, JD; Chiellini, G; Nguyen, NH; Scanlan, TS	1
Bernal, J; Manzano, J; Morte, B; Scanlan, TS	1
Baxter, JD; Beehler, BC; Chiellini, G; Egan, DM; Grover, GJ; Nguyen, NH; Scanlan, TS; Sleph, PG	1
Chiellini, G; Ermio, DJ; Furlow, JD; Hsu, M; Lim, W; Scanlan, TS; Yang, HY	1
Chiellini, G; Mishra, MK; Scanlan, TS; Wilson, FE	1
Capelo, LP; Freitas, FR; Gouveia, CH; Jorgetti, V; Moriscot, AS; O'Shea, PJ; Scanlan, TS; Williams, GR; Zorn, TM	1
Dowdell, S; Hubner, I; Koh, JT; Link, KH; Putnam, MC; Shi, Y; Ye, H	1
Angelin, B; Baxter, J; Johansson, L; Lundåsen, T; Parini, P; Rudling, M; Scanlan, TS; Webb, P	1
Kloas, W; Lutz, I; Nguyen, NH; Opitz, R; Scanlan, TS	1
Baxter, JD; Chiellini, G; Dillmann, WH; Giannocco, G; Gloss, B; Moriscot, AS; Scanlan, T; Swanson, EA	1
Bergh, JJ; Davis, FB; Davis, PJ; Mousa, SA; O'Connor, LJ; Scanlan, TS	1
Chiellini, G; Columbano, A; Cossu, C; Deidda, M; Ledda-Columbano, GM; Muntoni, S; Pibiri, M; Scanlan, TS	1
Aoki, MS; Bianco, AC; Freitas, FR; Gouveia, CH; Moriscot, AS; Ribeiro, MO; Scanlan, TS; Taffarel, C; Villicev, CM	1
Bernal, J; Cuadrado, M; Manzano, J; Morte, B	1
Aparicio, R; Baxter, JD; Bleicher, L; da Silva, R; Donate, PM; Figueira, AC; Gomes Dias, SM; Martinez, L; Neves, FA; Nunes, FM; Polikarpov, I; Santos, MA; Simeoni, LA; Skaf, MS; Venturelli, WH; Webb, P	1
Scanlan, TS	2
Cocco, MT; Columbano, A; Kowalik, MA; Ledda-Columbano, GM; Perra, A; Pibiri, M; Simbula, G; Simbula, M; Sulas, P	1
Josseaume, C; Lorcy, Y	1
Denver, RJ; Furlow, JD; Hu, F; Scanlan, TS	1
Cable, EE; Erion, MD; Finn, PD; Hou, J; Ito, BR; Linemeyer, DL; Stebbins, JW; van Poelje, PD	1
Beber, EH; Capelo, LP; Costa, CC; Fonseca, TL; Gouveia, CH; Lotfi, CF; Scanlan, TS	1
Bari, A; Chiellini, G; Columbano, A; Di Meo, S; Di Stefano, L; Scanlan, TS; Venditti, P; Zucchi, R	1
Genin, EC; Gondcaille, C; Savary, S; Trompier, D	1
Eller, P; Patsch, JR; Ritsch, A; Tancevski, I	1
Davis, FB; Davis, PJ; Mousa, SA; Mousa, SS	1
Chiellini, G; Columbano, A; Di Meo, S; Di Stefano, L; Napolitano, G; Scanlan, TS; Venditti, P; Zucchi, R	1
Cioffi, F; Goglia, F; Lanni, A	1
Martinez de Mena, R; Obregon, MJ; Scanlan, TS	1
Foguel, D; Lima, LM; Polikarpov, I; Sairre, MI; Trivella, DB	1
Demetz, E; Eller, P; Tancevski, I	1
Ayers, SD; Baxter, JD; Denoto-Reynolds, F; Lin, JZ; Sieglaff, DH; Webb, P; Yuan, C	1
Baxter, JD; Gustafsson, JÅ; Hsueh, WA; Lin, JZ; Martagón, AJ; Phillips, KJ; Webb, P	1
Cubelo, A; Fischer, JD; Guyenet, SJ; Kaiyala, KJ; Matsen, ME; Meek, TH; Morton, GJ; Ogimoto, K; Schwartz, MW; Thaler, JP; Wisse, BE	1
Baxter, J; Beddow, SA; Bogan, JS; Erion, DM; Grover, GJ; Kumashiro, N; Liao, XH; Phillips, KJ; Samuel, VT; Shulman, GI; Vatner, DF; Webb, P; Weismann, D; Weiss, RE	1
Noszál, B; Tóth, G	1
Baxi, EG; Bergles, DE; Calabresi, PA; Fairchild, AN; Karani, R; Kirby, LA; Pardo-Villamizar, C; Rothstein, JR; Schott, JT; Uapinyoying, P	1
Asano, Y; Maeda, K; Takahashi, N; Watanabe, N	1
Eggertsen, G; Gåfvels, M; Kannisto, K; Larsson, L; Parini, P; Rehnmark, S; Slätis, K; Webb, P	1
Cimini, SL; Lin, JZ; Martagón, AJ; Phillips, KJ; Webb, P	1
Furlanetto Júnior, R; Gonçalves, A; Huss, JC; Lopes, LT; Neves, Fde A; Souza, FR; Tolentino, CC; Zinato, Kde L	1
Izuchi, T; Takahashi, N	1
Brent, GA; Cervantes, V; Cheng, SY; Kahng, A; Kim, NH; Lee, JW; Liu, YY; Milanesi, A; Perin, L; Sedrakyan, S; Tripuraneni, N; Yang, A	1
Lammel Lindemann, J; Webb, P	1
Alvarado, TF; Columbano, A; Monga, SP; Nejak-Bowen, K; Poddar, M; Preziosi, M; Puliga, E; Singh, S	1
Ballerini, A; Filgueira, CS; Fraga, D; Gaber, AO; Garcia-Huidobro, J; Grattoni, A; Hood, RL; Lin, JZ; Nicolov, E; Phillips, KJ; Sabek, OM; Webb, P	1
Ferrara, SJ; Hartley, MD; Meinig, JM; Placzek, AT; Sanford-Crane, HS; Scanlan, TS	1
Banerji, T; Hartley, MD; Kirkemo, LL; Scanlan, TS	1
Ballerini, A; Chua, CYX; Filgueira, CS; Gilbert, AL; Grattoni, A; Jain, P; Nicolov, E; Scaglione, F; Smith, ZW	1
Banerji, T; Bourdette, D; Ferrara, SJ; Hartley, MD; McTigue, P; Meinig, JM; Placzek, AT; Sanford-Crane, HS; Scanlan, TS	1
Chiellini, G; Columbano, A; Kowalik, MA	1
Columbano, A; Min, Q; Monga, SP; Poddar, M; Pradhan-Sundd, T; Puliga, E; Singh, S; Tao, J; Yu, J; Zhang, R	1
Bárez-López, S; Grijota-Martínez, C; Guadaño-Ferraz, A; Hartley, MD; Scanlan, TS	1
Bourdette, D; Ferrara, SJ; Scanlan, TS	1
Devereaux, J; Ferrara, SJ; Scanlan, TS	1
Ali, A; Ballerini, A; Bruno, G; Chua, CYX; Filgueira, CS; Folci, M; Gilbert, AL; Grattoni, A; Hill, LR; Jain, P; Nehete, PN; Sastry, JK; Shelton, KA; Smith, ZW; Youker, KA	1
Aiyer, A; Asp, P; Barahman, M; Beck, AP; Guha, C; Harris, HY; Kabarriti, R; Kinkhabwala, M; Roy-Chowdhury, J; Roy-Chowdhury, N; Scanlan, TS; Zhang, W	1
Adebayo Michael, AO; Calvisi, D; Chen, X; Görg, B; Häussinger, D; Ko, S; Liu, P; Liu, S; Moghe, A; Monga, JS; Monga, SP; Oertel, M; Poddar, M; Pradhan-Sundd, T; Qvartskhava, N; Ranganathan, S; Rebouissou, S; Ribback, S; Russell, JO; Singh, S; Singhi, A; Tao, J; Xu, M; Yang, H; Zucman-Rossi, J	1
Banerji, T; Bourdette, D; Calkins, E; Chaudhary, P; DeBell, MJ; Emery, B; Ferrara, SJ; Galipeau, D; Hartley, MD; Kirkemo, LL; Marracci, G; Meinig, JM; Miller, H; Pocius, E; Scanlan, TS; Shokat, MD; Tagge, IJ; Van Leuven, S	1
Cioffi, F; Goglia, F; Lanni, A; Petito, G; Senese, R	1
Zucchi, R	1
Banerji, T; DeBell, MJ; Hartley, MD; Kirkemo, LL; Scanlan, TS; Shokat, MD	1
Cornuet, P; Kosar, K; Liu, S; Nejak-Bowen, K; Singh, S	1
Kong, L; Ma, J; Sun, Y; Tang, M; Wu, Y	1
Ding, X; Huang, T; Kuang, H; Lin, T; Wu, L; Yang, B; Zhang, D; Zhang, W; Zhang, Y; Zou, W	1
Beigelman, LN; Blatt, LM; Chanda, S; Deval, J; Gupta, K; Jekle, A; Lin, TI; Luong, XG; McGowan, D; Misner, D; Mukherjee, S; Raboisson, P; Stevens, SK; Stoycheva, A; Symons, JA; Vandyck, K; Williams, C	1
Bensen, AL; Bourdette, DN; Calkins, E; Chaudhary, P; Emery, B; Marracci, GH; Pocius, E; Scanlan, TS	1
Hu, W; Kong, L; Liang, G; Liu, L; Wu, Y; Xue, Y	1
Chiellini, G; Kim, B; Kim, JH; Ko, YH; Ortore, G; Rapposelli, S; Runfola, M	1
Bourdette, D; Calkins, E; Chaudhary, P; DeBell, MJ; Emery, B; Ferrara, SJ; Marracci, G; Miller, H; Napier, BA; Pocius, E; Scanlan, TS	1
Fei, Q; Huang, X; Jin, J; Kong, X; Li, H; Pan, C; Wu, D; Zheng, J	1
Ghorbani, A; Pourvali, K; Shakery, A; Shimi, G; Shirazi, FH; Zand, H	1
Huang, C; Lv, J; Shen, C; Shu, M; Wu, T; Xue, J; Zheng, B	1

Reviews

9 review(s) available for phenyl acetate and gc 1 compound

Article	Year
Thyroid hormone analogues: useful biological probes and potential therapeutic agents. Annales d'endocrinologie, 2008, Volume: 69, Issue:2 Topics: Acetates; Humans; Phenols; Thyroid Hormones; Thyroxine; Triiodothyronine	2008
Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart failure reviews, 2010, Volume: 15, Issue:2 Topics: Acetates; Animals; Binding Sites; Drug Discovery; Humans; Phenols; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Tissue Distribution	2010
The resurgence of thyromimetics as lipid-modifying agents. Current opinion in investigational drugs (London, England : 2000), 2009, Volume: 10, Issue:9 Topics: Acetates; Anilides; Animals; Anticholesteremic Agents; Arteriosclerosis; Atherosclerosis; Biological Transport; Biomimetics; Cholesterol, LDL; Clinical Trials as Topic; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lipid Metabolism; Malonates; Molecular Structure; Organophosphonates; Phenols; Phenyl Ethers; Phenylacetates; Propionates; Pyridazines; Receptors, LDL; Thyroid Gland; Thyroid Hormones	2009
Thyroid hormones, mitochondrial bioenergetics and lipid handling. Current opinion in endocrinology, diabetes, and obesity, 2010, Volume: 17, Issue:5 Topics: Acetates; Adiposity; Anilides; Animals; Atherosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Diiodothyronines; Dyslipidemias; Energy Metabolism; Fatty Liver; Humans; Lipid Metabolism; Mice; Mitochondria; Obesity; Phenols; Rats; Thyroid Hormones	2010
Sobetirome: a selective thyromimetic for the treatment of dyslipidemia. Recent patents on cardiovascular drug discovery, 2011, Volume: 6, Issue:1 Topics: Acetates; Animals; Bile Acids and Salts; Biomarkers; Cholesterol; Dyslipidemias; Humans; Hypolipidemic Agents; Liver; Molecular Mimicry; Phenols; Receptors, LDL; Thyroid Hormones; Treatment Outcome; Triglycerides	2011
[Thyroid hormones and their precursors I. Biochemical properties]. Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:2 Topics: Acetates; Biological Transport; Diiodothyronines; Diiodotyrosine; Humans; Hydrogen-Ion Concentration; Membrane Transport Proteins; Monoiodotyrosine; Phenols; Phenyl Ethers; Phenylacetates; Protein Isoforms; Receptors, Thyroid Hormone; Structure-Activity Relationship; Thyroid Hormones; Thyroxine; Thyroxine-Binding Globulin; Triiodothyronine; Triiodothyronine, Reverse	2013
GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease. Gene expression, 2017, 11-27, Volume: 17, Issue:4 Topics: Acetates; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Hepatocytes; Humans; Liver Diseases; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; Phenols; Thyroid Hormone Receptors beta	2017
Thyroid hormone metabolites and analogues. Endocrine, 2019, Volume: 66, Issue:1 Topics: Acetates; Anilides; Animals; Diiodothyronines; Humans; Phenols; Phenyl Ethers; Phenylacetates; Propionates; Thyroid Hormones	2019
Thyroid Hormone Analogues: An Update. Thyroid : official journal of the American Thyroid Association, 2020, Volume: 30, Issue:8 Topics: Acetates; Anilides; Animals; Central Nervous System Diseases; Clinical Trials as Topic; Diiodothyronines; Drug Design; Dyslipidemias; Humans; Liver Diseases; Male; Mice; Mutation; Non-alcoholic Fatty Liver Disease; Phenols; Pyridazines; Rats; Signal Transduction; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Thyroid Hormones; Thyronines; Triiodothyronine; Uracil	2020

Other Studies

69 other study(ies) available for phenyl acetate and gc 1 compound

Article	Year
The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology, 2000, Volume: 141, Issue:9 Topics: Acetates; Animals; Blotting, Northern; Body Weight; Dose-Response Relationship, Drug; Heart; Hemodynamics; Hypercholesterolemia; Hypolipidemic Agents; Hypothyroidism; Lipids; Male; Mice; Organ Size; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; RNA, Messenger; Thyroxine; Triiodothyronine	2000
Hormone selectivity in thyroid hormone receptors. Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:3 Topics: Acetates; Amino Acid Sequence; Asparagine; Binding Sites; Crystallography, X-Ray; Humans; Molecular Sequence Data; Mutation; Phenols; Protein Conformation; Receptors, Thyroid Hormone; Sequence Homology, Amino Acid; Thyroid Hormones; Triiodothyronine	2001
Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. The Journal of clinical investigation, 2001, Volume: 108, Issue:1 Topics: Acetates; Adaptation, Physiological; Adipocytes; Adipose Tissue, Brown; Animals; Carrier Proteins; Cold Temperature; Cyclic AMP; Gene Expression Regulation; Glycerolphosphate Dehydrogenase; Heart Rate; Humans; Hypothyroidism; Ion Channels; Liver; Malate Dehydrogenase; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Norepinephrine; Phenols; Protein Isoforms; Rats; Receptors, Thyroid Hormone; Sympathetic Nervous System; Thermogenesis; Thyroid Hormones; Triiodothyronine; Uncoupling Protein 1	2001
A designed antagonist of the thyroid hormone receptor. Bioorganic & medicinal chemistry letters, 2001, Nov-05, Volume: 11, Issue:21 Topics: Acetates; Binding, Competitive; Biphenyl Compounds; Carboxylic Acids; Crystallography, X-Ray; Molecular Structure; Phenols; Receptors, Thyroid Hormone	2001
Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:2 Topics: Acetates; Biphenyl Compounds; Carboxylic Acids; Drug Design; Drug Evaluation, Preclinical; HeLa Cells; Humans; Phenols; Receptors, Thyroid Hormone; Structure-Activity Relationship; Thyroid Hormones; Transcriptional Activation	2002
Structural determinants of selective thyromimetics. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Acetates; Binding, Competitive; Humans; Ligands; Phenols; Structure-Activity Relationship; Thyroid Hormone Receptors beta	2003
Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology, 2003, Volume: 144, Issue:12 Topics: Acetates; Animals; Brain; Calmodulin-Binding Proteins; Caudate Nucleus; Cerebellum; Female; Gene Expression; GTP-Binding Proteins; Male; Mice; Mice, Mutant Strains; Neocortex; Nerve Tissue Proteins; Neurogranin; Phenols; Pregnancy; Rats; Rats, Wistar; Receptors, Thyroid Hormone; Reelin Protein; Thyroid Hormone Receptors beta; Thyroxine; Triiodothyronine	2003
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology, 2004, Volume: 145, Issue:4 Topics: Acetates; Animals; Body Weight; Cholesterol; Cholesterol, Dietary; Dose-Response Relationship, Drug; Female; Heart Rate; Lipoprotein(a); Macaca fascicularis; Male; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; Triiodothyronine	2004
Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. The Journal of biological chemistry, 2004, Jun-18, Volume: 279, Issue:25 Topics: Acetates; Animals; Blotting, Northern; Cell Nucleus; DNA Mutational Analysis; Dose-Response Relationship, Drug; Ligands; Metamorphosis, Biological; Models, Chemical; Phenols; Protein Binding; Transcriptional Activation; Triiodothyronine; Xenopus laevis	2004
Thyroid hormone-dependent seasonality in American tree sparrows (Spizella arborea): effects of GC-1, a thyroid receptor beta-selective agonist, and of iopanoic acid, a deiodinase inhibitor. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2004, Volume: 174, Issue:6 Topics: Acclimatization; Acetates; Analysis of Variance; Animals; Iodide Peroxidase; Iopanoic Acid; Kansas; Male; Molting; Phenols; Photic Stimulation; Photoperiod; Receptors, Thyroid Hormone; Seasons; Sparrows; Testis; Thyroid Hormones	2004
The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005, Volume: 20, Issue:2 Topics: Absorptiometry, Photon; Acetates; Animals; Body Size; Bone and Bones; Bone Density; Bone Development; Cell Differentiation; Chondrocytes; Collagen Type II; Collagen Type X; Female; Growth Plate; Humans; Hypothyroidism; Immunohistochemistry; In Situ Hybridization; Insulin-Like Growth Factor I; Osteogenesis; Phenols; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Thyroid Hormone; RNA, Messenger; Thyroid Hormone Receptors beta; Time Factors	2005
Mutant-selective thyromimetics for the chemical rescue of thyroid hormone receptor mutants associated with resistance to thyroid hormone. Biochemistry, 2005, Mar-29, Volume: 44, Issue:12 Topics: Acetates; Arginine; Carboxylic Acids; Cell Line; Cysteine; Drug Resistance; Glycine; Histidine; Humans; Ligands; Molecular Mimicry; Mutagenesis, Site-Directed; Phenols; Promoter Regions, Genetic; Protein Binding; Receptors, Thyroid Hormone; Repetitive Sequences, Nucleic Acid; Response Elements; Thyroid Hormone Receptors beta; Thyrotropin; Triiodothyronine	2005
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proceedings of the National Academy of Sciences of the United States of America, 2005, Jul-19, Volume: 102, Issue:29 Topics: Acetates; Analysis of Variance; Animals; Bile Acids and Salts; Cardiovascular Diseases; CD36 Antigens; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Feces; Gene Expression Regulation; Hypercholesterolemia; Immunoblotting; Liver; Male; Mice; Mice, Inbred C57BL; Phenols; Phenyl Ethers; Phenylacetates; Receptors, Immunologic; Receptors, Scavenger; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormone Receptors beta; Triglycerides; Triiodothyronine	2005
Analysis of thyroid hormone receptor betaA mRNA expression in Xenopus laevis tadpoles as a means to detect agonism and antagonism of thyroid hormone action. Toxicology and applied pharmacology, 2006, Apr-01, Volume: 212, Issue:1 Topics: Acetates; Animals; Antithyroid Agents; Biomarkers; Data Interpretation, Statistical; Drug Evaluation, Preclinical; Endocrine Disruptors; Gene Expression Regulation; Hindlimb; Indicators and Reagents; Larva; Metamorphosis, Biological; Phenols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Thyroid Hormones; Xenopus laevis	2006
Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression. Endocrinology, 2005, Volume: 146, Issue:11 Topics: Acetates; Animals; Base Sequence; Calcium-Transporting ATPases; Cells, Cultured; Chromatin Immunoprecipitation; DNA; Gene Expression; Histone Acetyltransferases; Histone Deacetylases; Molecular Sequence Data; Mutation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Phenols; Promoter Regions, Genetic; Rats; Receptors, Thyroid Hormone; Repressor Proteins; Response Elements; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Transcription Factors; Triiodothyronine	2005
The proangiogenic action of thyroid hormone analogue GC-1 is initiated at an integrin. Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:3 Topics: Acetates; Animals; Cell Membrane; Chick Embryo; Chorion; Fibroblast Growth Factor 2; Indicators and Reagents; Integrin alphaVbeta3; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; Phenols; Regional Blood Flow; Thyroid Hormone Receptors beta; Thyroxine	2005
The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology, 2006, Volume: 147, Issue:7 Topics: Acetates; Animals; Cell Cycle; Cell Proliferation; Hepatocytes; Lipids; Liver; Male; Pancreas; Phenols; Rats; Rats, Inbred F344; Rats, Wistar; Thyroid Hormone Receptors beta; Thyroid Hormones	2006
Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. The Journal of endocrinology, 2007, Volume: 193, Issue:1 Topics: Absorptiometry, Photon; Acetates; Adipose Tissue; Animals; Body Composition; Energy Metabolism; Female; Heart; Muscle, Skeletal; Obesity; Organ Size; Oxygen Consumption; Phenols; Random Allocation; Rats; Rats, Wistar; Thyroid Hormone Receptors beta; Triiodothyronine	2007
Influence of thyroid hormone and thyroid hormone receptors in the generation of cerebellar gamma-aminobutyric acid-ergic interneurons from precursor cells. Endocrinology, 2007, Volume: 148, Issue:12 Topics: Acetates; Age Factors; Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Cerebellum; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hypothyroidism; Immunohistochemistry; Interneurons; Ki-67 Antigen; Mice; Mice, Inbred BALB C; PAX2 Transcription Factor; Phenols; Rats; Rats, Wistar; Receptors, Thyroid Hormone; Thyroid Hormones	2007
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. BMC structural biology, 2008, Jan-31, Volume: 8 Topics: Acetates; Binding Sites; Computer Simulation; Crystallography, X-Ray; HeLa Cells; Humans; Ligands; Models, Biological; Phenols; Protein Isoforms; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta	2008
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:8 Topics: Acetates; Animals; Base Sequence; Diet; Disease Models, Animal; DNA Primers; Fatty Liver; Lipid Peroxidation; Liver; Male; Phenols; Rats; Rats, Inbred F344; Thyroid Hormone Receptors beta; Triglycerides; Triiodothyronine	2008
[Thyroid hormone analogs: an important biological supply and new therapeutic possibilities]. Annales d'endocrinologie, 2008, Volume: 69 Suppl 1 Topics: Acetates; Anilides; Anticholesteremic Agents; Humans; Hypolipidemic Agents; Phenols; Phenyl Ethers; Phenylacetates; Receptors, Thyroid Hormone; Signal Transduction; Thyroid Hormones; Triiodothyronine	2008
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Developmental biology, 2009, Feb-01, Volume: 326, Issue:1 Topics: Acetates; Animals; Benzhydryl Compounds; Brain; Cell Proliferation; Green Fluorescent Proteins; Hydantoins; Larva; Metamorphosis, Biological; Neurogenesis; Phenols; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine; Xenopus laevis	2009
Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:2 Topics: Acetates; Adipose Tissue; Animals; Cytochrome P-450 CYP3A; Epididymis; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Phenols; Phenyl Ethers; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone	2009
The thyroid hormone receptor (TR) beta-selective agonist GC-1 inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Calcified tissue international, 2009, Volume: 84, Issue:4 Topics: Acetates; Alkaline Phosphatase; Animals; Cell Differentiation; Cell Line; Cell Proliferation; Gene Expression; Mice; Osteoblasts; Osteocalcin; Phenols; Polymerase Chain Reaction; Rats; RNA, Messenger; Thyroid Hormone Receptors beta; Triiodothyronine	2009
T3 and the thyroid hormone beta-receptor agonist GC-1 differentially affect metabolic capacity and oxidative damage in rat tissues. The Journal of experimental biology, 2009, Volume: 212, Issue:Pt 7 Topics: Acetates; Analysis of Variance; Animals; Calorimetry; Electrocardiography; Electron Transport Complex IV; Energy Metabolism; Heart; Heart Rate; Liver; Male; Muscle, Skeletal; Oxidative Stress; Oxygen Consumption; Phenols; Rats; Rats, Wistar; Thyroid Hormone Receptors beta; Triiodothyronine	2009
Induction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics. The Journal of steroid biochemistry and molecular biology, 2009, Volume: 116, Issue:1-2 Topics: Acetates; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D; ATP-Binding Cassette Transporters; Chlorocebus aethiops; COS Cells; Glyoxylates; Humans; Phenols; Rats; Thyroid Hormones; Transfection; Triiodothyronine; Up-Regulation	2009
Human platelet aggregation and degranulation is induced in vitro by L-thyroxine, but not by 3,5,3'-triiodo-L-thyronine or diiodothyropropionic acid (DITPA). Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2010, Volume: 16, Issue:3 Topics: Acetates; Adenosine Triphosphate; Adolescent; Blood Platelets; Collagen; Cytoplasmic Granules; Diiodothyronines; Female; Humans; Imidazoles; Male; Phenols; Platelet Activation; Platelet Aggregation; Propionates; Receptors, Thyroid Hormone; Substrate Specificity; Thyroxine; Triiodothyronine; Young Adult	2010
The TRbeta-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine. The Journal of endocrinology, 2010, Volume: 205, Issue:3 Topics: Acetates; Animals; GA-Binding Protein Transcription Factor; Hydrogen Peroxide; Male; Mitochondria; Models, Animal; Nuclear Respiratory Factor 1; Oxidation-Reduction; Oxygen Consumption; Phenols; PPAR gamma; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Triiodothyronine	2010
The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology, 2010, Volume: 151, Issue:10 Topics: Acetates; Adipose Tissue, Brown; Adrenergic Agents; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hydantoins; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Ion Channels; Mitochondrial Proteins; Norepinephrine; Phenols; Protein Isoforms; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Thyroid Hormone Receptors beta; Triiodothyronine; Uncoupling Protein 1	2010
The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition. Journal of structural biology, 2011, Volume: 173, Issue:2 Topics: Acetates; Benzhydryl Compounds; Calorimetry; Humans; Phenols; Prealbumin; Thyroid Hormone Receptors beta; Triiodothyronine; X-Ray Diffraction	2011
Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1. Endocrinology, 2012, Volume: 153, Issue:1 Topics: Acetates; Angiopoietin-Like Protein 4; Angiopoietins; Animals; Binding Sites; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Phenols; Receptors, Thyroid Hormone; RNA, Small Interfering; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine	2012
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology, 2012, Volume: 153, Issue:12 Topics: Acetates; Anilides; Animals; Apolipoproteins B; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Feces; Lipoproteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenols; Receptors, LDL; Receptors, Thyroid Hormone; Thyroid Hormone Receptors beta; Triglycerides; Triiodothyronine	2012
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. American journal of physiology. Endocrinology and metabolism, 2013, Apr-01, Volume: 304, Issue:7 Topics: Acetates; Adipose Tissue, Brown; Adrenergic beta-3 Receptor Agonists; Animals; Body Composition; Diabetes Mellitus, Experimental; Eating; Glucose; Hyperglycemia; Ion Channels; Male; Mitochondrial Proteins; Phenols; Rats; Rats, Wistar; Receptors, Adrenergic, beta-3; Streptozocin; Sympathetic Nervous System; Thermogenesis; Thyroid Hormone Receptors beta; Triiodothyronine; Uncoupling Protein 1	2013
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. American journal of physiology. Endocrinology and metabolism, 2013, Jul-01, Volume: 305, Issue:1 Topics: Acetates; Anilides; Animals; Dietary Fats; Fatty Liver; Gene Expression; Gluconeogenesis; Glucose Transporter Type 4; Hyperglycemia; Hyperinsulinism; Insulin Resistance; Male; Muscle, Skeletal; Non-alcoholic Fatty Liver Disease; Phenols; Rats; Rats, Sprague-Dawley; Signal Transduction; Thyroid Hormone Receptors beta; Triglycerides	2013
A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation. Glia, 2014, Volume: 62, Issue:9 Topics: Acetates; Adolescent; Animals; Brain; Cells, Cultured; Central Nervous System Agents; Child; Child, Preschool; Epilepsy; Gray Matter; Humans; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Oligodendroglia; Optic Nerve; Phenols; Rats, Sprague-Dawley; Thyroid Hormone Receptors beta; Young Adult	2014
In vivo evaluation of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists: importance of liver selectivity in drug discovery. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:7 Topics: Acetates; Administration, Oral; Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Discovery; Heart Rate; Hypertriglyceridemia; Indoles; Injections, Intravenous; Lipids; Liver; Male; Malonates; Molecular Structure; Phenols; Rats, Sprague-Dawley; Structure-Activity Relationship; Thyroid Hormone Receptors beta; Thyroxine; Tissue Distribution; Triiodothyronine	2014
The thyroid receptor β modulator GC-1 reduces atherosclerosis in ApoE deficient mice. Atherosclerosis, 2014, Volume: 237, Issue:2 Topics: Acetates; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Bile Acids and Salts; Biological Transport; Cholesterol; Disease Models, Animal; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenols; Phytosterols; Receptors, LDL; Sterols; Thyroid Hormone Receptors beta; Time Factors	2014
The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PloS one, 2015, Volume: 10, Issue:4 Topics: Acetates; Anilides; Animals; Blood Glucose; Body Temperature; Dose-Response Relationship, Drug; Enzyme Induction; Glucose-6-Phosphatase; Insulin Resistance; Male; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Phenols; Receptors, Thyroid Hormone; Time Factors	2015
The thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid rats. Archives of endocrinology and metabolism, 2015, Volume: 59, Issue:2 Topics: Acetates; Animals; Exercise Tolerance; Hypothyroidism; Methimazole; Muscle, Skeletal; Myocytes, Cardiac; Perchlorates; Phenols; Rats, Wistar; Sodium Compounds; Swimming; Thyroid Hormone Receptors beta; Thyrotropin; Thyroxine; Triiodothyronine	2015
Characterisation of liver-specific distribution of a novel 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonist, SKL-13784: comparison with GC-1. Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:2 Topics: Acetates; Animals; Bile; Brain; Chromatography, Liquid; Glucuronides; Heart; Hepatocytes; Indoles; Liver; Male; Malonates; Microsomes, Liver; Phenols; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Thyroid Hormone Receptors beta; Tissue Distribution	2016
Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury. Endocrinology, 2016, Volume: 157, Issue:1 Topics: Acetates; Animals; Cell Line; Cell Proliferation; Cells, Cultured; Drug Resistance; Frameshift Mutation; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Development; Muscle, Skeletal; Myoblasts, Skeletal; Phenols; Regeneration; RNA Interference; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine; Wnt Signaling Pathway	2016
Sobetirome: the past, present and questions about the future. Expert opinion on therapeutic targets, 2016, Volume: 20, Issue:2 Topics: Acetates; Animals; Cardiovascular Diseases; Cholesterol; Clinical Trials as Topic; Dogs; Dyslipidemias; Humans; Liver; Phenols; Thyroid Hormone Receptors beta	2016
Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration. Gene expression, 2016, Volume: 17, Issue:1 Topics: Acetates; Animals; beta Catenin; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Hepatectomy; Hepatocytes; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Phenols; Thyroid Hormone Receptors beta; Triiodothyronine; Wnt Signaling Pathway	2016
Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome. International journal of obesity (2005), 2016, Volume: 40, Issue:11 Topics: Acetates; Animals; Diet, High-Fat; Disease Models, Animal; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Obese; Molecular Targeted Therapy; Obesity; Phenols; Thyroid Hormone Receptors beta	2016
Sobetirome prodrug esters with enhanced blood-brain barrier permeability. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Acetates; Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Esters; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Permeability; Phenols; Prodrugs; Structure-Activity Relationship	2016
A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy. Endocrinology, 2017, 05-01, Volume: 158, Issue:5 Topics: Acetates; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Brain; Cell Line; Fatty Acids; Fibroblasts; Humans; Male; Mice; Peroxisomes; Phenols; Receptors, Thyroid Hormone; Thyroid Hormones	2017
A pharmacokinetic study of GC-1 delivery using a nanochannel membrane device. Nanomedicine : nanotechnology, biology, and medicine, 2017, Volume: 13, Issue:5 Topics: Acetates; Animals; Body Weight; Liver; Nanotechnology; Phenols; Rats; Rats, Inbred F344	2017
Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration. Bioorganic & medicinal chemistry, 2017, 05-15, Volume: 25, Issue:10 Topics: Acetates; Administration, Oral; Amides; Animals; Area Under Curve; Blood-Brain Barrier; Brain; Esters; Ethanolamine; Half-Life; Male; Mice; Mice, Inbred C57BL; Phenols; Prodrugs; ROC Curve	2017
Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer. The American journal of pathology, 2017, Volume: 187, Issue:11 Topics: Acetates; beta Catenin; Carcinoma, Hepatocellular; Cell Proliferation; Hepatic Insufficiency; Humans; Liver Neoplasms; Phenols	2017
Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain. Thyroid : official journal of the American Thyroid Association, 2018, Volume: 28, Issue:9 Topics: Acetates; Animals; Brain; Membrane Transport Proteins; Mice; Mice, Knockout; Monocarboxylic Acid Transporters; Phenols; Prodrugs; Symporters; Thyroxine; Triiodothyronine; Uncoupling Protein 2	2018
Hypothalamic-Pituitary-Thyroid Axis Perturbations in Male Mice by CNS-Penetrating Thyromimetics. Endocrinology, 2018, 07-01, Volume: 159, Issue:7 Topics: Acetates; Animals; Central Nervous System; Hypothalamo-Hypophyseal System; Hypothyroidism; Male; Mice; Mice, Inbred C57BL; Phenols; Pituitary Gland; Radioimmunoassay; Thyroid Gland; Thyroid Hormones; Thyroxine; Triiodothyronine	2018
Quantification of Thyromimetic Sobetirome Concentration in Biological Tissue Samples. Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1801 Topics: Acetates; Animals; Chromatography, Liquid; Humans; Metabolic Networks and Pathways; Mice; Molecular Mimicry; Molecular Structure; Phenols; Tandem Mass Spectrometry; Thyroid Hormones; Tissue Distribution	2018
Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study. Biomedical microdevices, 2018, 06-18, Volume: 20, Issue:2 Topics: Acetates; Animals; Drug Delivery Systems; Macaca mulatta; Nanotechnology; Obesity; Phenols	2018
Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis. Journal of hepatology, 2019, Volume: 70, Issue:6 Topics: Acetates; Animals; Apolipoproteins E; Atherosclerosis; Cholesterol; Disease Models, Animal; Dyslipidemias; Female; Hepatocytes; Hyperlipoproteinemia Type II; Male; Mice; Mice, Inbred C57BL; Phenols	2019
Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations. Cell metabolism, 2019, 05-07, Volume: 29, Issue:5 Topics: Acetates; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Child, Preschool; Disease Models, Animal; Female; Glutamate-Ammonia Ligase; Glutamine; Hepatocytes; Humans; Infant; Liver Neoplasms; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenols; Retrospective Studies; Sirolimus; TOR Serine-Threonine Kinases; Transfection; Wnt Signaling Pathway	2019
Myelin repair stimulated by CNS-selective thyroid hormone action. JCI insight, 2019, 04-18, Volume: 4, Issue:8 Topics: Acetates; Animals; Axons; Cell Differentiation; Disease Models, Animal; Female; Gene Knockdown Techniques; Gliotoxin; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Phenols; Prodrugs; Remyelination; Thyroid Hormones; Transcription Factors; White Matter	2019
Pharmacological Complementation Remedies an Inborn Error of Lipid Metabolism. Cell chemical biology, 2020, 05-21, Volume: 27, Issue:5 Topics: Acetates; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; Disease Models, Animal; Fatty Acids; Female; Humans; Lipid Metabolism, Inborn Errors; Male; Mice; Mice, Knockout; Phenols; Prodrugs; Thyroid Hormones	2020
The Thyromimetic Sobetirome (GC-1) Alters Bile Acid Metabolism in a Mouse Model of Hepatic Cholestasis. The American journal of pathology, 2020, Volume: 190, Issue:5 Topics: Acetates; Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Disease Models, Animal; Hepatocytes; Mice; Mice, Knockout; Phenols	2020
Effect and mechanism of PI3K/AKT/mTOR signaling pathway in the apoptosis of GC-1 cells induced by nickel nanoparticles. Chemosphere, 2020, Volume: 255 Topics: Acetates; Animals; Apoptosis; Cell Line; Cell Proliferation; Humans; Male; Metal Nanoparticles; Mice; Nickel; Phenols; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases	2020
Perfluorooctanoic acid induces cytotoxicity in spermatogonial GC-1 cells. Chemosphere, 2020, Volume: 260 Topics: Acetates; Animals; Apoptosis; Autophagy; Caprylates; Fluorocarbons; Male; Membrane Potential, Mitochondrial; Mice; Phenols; Reactive Oxygen Species; Superoxide Dismutase	2020
Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH). PloS one, 2020, Volume: 15, Issue:12 Topics: Acetates; Angiopoietin-Like Protein 4; Animals; Cell Line, Tumor; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Hepatocytes; Humans; Iodide Peroxidase; Liver; Malate Dehydrogenase; Male; Non-alcoholic Fatty Liver Disease; Organophosphonates; Phenols; Primary Cell Culture; Pyridazines; Rats; Thyroid Hormone Receptors beta; Transcription, Genetic; Uracil	2020
Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE. Journal of neuroimmunology, 2021, 03-15, Volume: 352 Topics: Acetates; Animals; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Degeneration; Oligodendroglia; Phenols; Prodrugs; Triiodothyronine	2021
Mechanisms underlying reproductive toxicity induced by nickel nanoparticles identified by comprehensive gene expression analysis in GC-1 spg cells. Environmental pollution (Barking, Essex : 1987), 2021, Apr-15, Volume: 275 Topics: Acetates; Animals; Apoptosis; Gene Expression; Male; Mice; Nanoparticles; Nickel; Phenols; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt	2021
Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis. International journal of molecular sciences, 2021, Mar-28, Volume: 22, Issue:7 Topics: Acetates; Amyloid; Amyloid Neuropathies, Familial; Benzothiazoles; Biphenyl Compounds; Drug Design; Humans; Magnetic Resonance Spectroscopy; Methane; Molecular Docking Simulation; Molecular Dynamics Simulation; Permeability; Phenols; Prealbumin; Protein Binding; Protein Folding; Recombinant Proteins; Thyroid Hormones	2021
TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor. Cell chemical biology, 2022, 02-17, Volume: 29, Issue:2 Topics: Acetates; Animals; Binding Sites; Brain; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Humans; Immunity, Innate; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microglia; Models, Molecular; Phenols; Phenoxyacetates; Promoter Regions, Genetic; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptors, Immunologic; Response Elements; Retinoid X Receptors; RNA, Messenger; Signal Transduction; Thyroid Hormones	2022
LncRNA HOTAIR promotes proliferation and suppresses apoptosis of mouse spermatogonium GC-1 cells by sponging miR-761 to modulate NANOS2 expression. In vitro cellular & developmental biology. Animal, 2022, Volume: 58, Issue:4 Topics: Acetates; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Male; Mice; MicroRNAs; Phenols; RNA-Binding Proteins; RNA, Long Noncoding; Spermatogonia	2022
Selective thyroid hormone receptor beta agonist, GC-1, is capable to reduce growth of colorectal tumor in syngeneic mouse models. Journal of receptor and signal transduction research, 2022, Volume: 42, Issue:5 Topics: Acetates; Animals; Colorectal Neoplasms; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Mice; Phenols; Thyroid Hormone Receptors beta; Thyroid Hormones	2022
Identification of proline-rich protein 11 as a major regulator in mouse spermatogonia maintenance via an increase in BMI1 protein stability. Molecular biology reports, 2022, Volume: 49, Issue:10 Topics: Acetates; Animals; Cell Line, Tumor; Cell Proliferation; Deoxyuridine; DNA Nucleotidylexotransferase; Male; Mice; Phenols; Polycomb Repressive Complex 1; Proline; Protein Stability; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Spermatogonia	2022