phenyl acetate has been researched along with dichloroacetic acid in 204 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 143 (70.10) | 18.7374 |
| 1990's | 23 (11.27) | 18.2507 |
| 2000's | 20 (9.80) | 29.6817 |
| 2010's | 14 (6.86) | 24.3611 |
| 2020's | 4 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Lignon, F; Loubatières, A; Ribes, G; Rondot, AM; Valette, G | 1 |
| Loubatieres, A; Loubatieres-Mariani, MM; Ribes, G; Rondot, AM; Valette, G | 1 |
| Irsigler, K; Kaspar, L; Kritz, H | 1 |
| Alberti, KG; Holloway, PA; Nattrass, M | 1 |
| Loubatieres-Mariani, MM; Ribes, G; Valette, G | 1 |
| Alric, R; Blayac, JP; Loubatières, AL; Loubatières-Mariani, MM; Valette, G | 1 |
| Kornhauser, DM; Moore, GW; Stacpoole, PW | 2 |
| Haslbeck, M; Janka, HU; Mehnert, H; Standl, A; Standl, E | 1 |
| Misbin, RI | 1 |
| Crofford, OB; Moore, GW; Oates, JA; Rabinowitz, D; Stacpoole, PW; Swift, LL | 1 |
| Crabb, DW; Harris, RA | 3 |
| Brändle, J; Irsigler, K; Kaspar, L; Kritz, H; Lageder, H; Regal, H | 1 |
| Relman, AS | 1 |
| Burges, RA; Higgins, AJ; Morville, M | 1 |
| Lacey, JH; Randle, PJ | 1 |
| McInnes, AG; Paramasigamani, K; Simonsen, JN; Vining, LC; Walter, JA; Wright, JL | 1 |
| Cohen, RD; Iles, RA | 1 |
| Crabb, DW; Harris, RA; Sans, RM | 1 |
| Charpentier, C; Coude, FX; DeMaugre, F; Leroux, JP; Marsac, C; Saudubray, JM | 1 |
| Aoki, TT; Goodman, MN; Ruderman, NB | 1 |
| Ferré, P; Girard, J; Leturque, A; Pegorier, JP | 1 |
| Cepanec, C; Demaugre, F; Leroux, JP | 1 |
| Haslbeck, M; Janka, HU; Mehnert, H; Standl, E; Wittmann, P | 1 |
| Alberti, KG; Johnson, GA | 1 |
| Berndt, WO; Davis, ME | 1 |
| Dimlich, RV; Shipley, MT; Showers, MJ | 1 |
| Ansari, GA; Bhat, HK; Campbell, GA; Kanz, MF | 1 |
| Moulart, D; Preiser, JC; Vincent, JL | 1 |
| Graf, H; Peer, G | 1 |
| Cameron, DF; Cornwell, PE; Curry, SH; Harwood, HJ; Samuelson, DA; Sauberlich, HE; Stacpoole, PW | 1 |
| Goodman, JC; Grossman, RG; Priessman, A; Robertson, CS | 1 |
| D'Alecy, LG; LeMay, DR; Zelenock, GB | 1 |
| Mizushima, M | 1 |
| Burns, AH; Burns, LA; Shepherd, RE; Summer, WR | 1 |
| Stacpoole, PW | 1 |
| Curry, SH | 1 |
| Sahlin, K | 1 |
| Morris, JG; Placko, R; Siegel, JH; Tall, BD; Vary, TC | 1 |
| Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF | 1 |
| Carraro, F; Klein, S; Rosenblatt, JI; Wolfe, RR | 1 |
| Katayama, Y; Welsh, FA | 1 |
| Randall, JL; Read, EJ; Smith, MK; Stober, JA | 1 |
| Burns, AH; Racey-Burns, LA; Shepherd, RE; Summer, WR | 1 |
| Ito, M; Kobashi, H; Kuroda, Y; Naito, E; Saijo, T; Takeda, E; Toshima, K; Yokota, I | 1 |
| Bull, RJ; Lansing, AJ; Nelson, MA; Sanchez, IM; Springer, DL | 1 |
| Fujita, Y; Fukui, A; Ohsumi, A; Sakai, T; Takaori, M; Yoshida, H | 1 |
| Daniel, FB; DeAngelo, AB; McMillan, L; Savage, RE; Wernsing, P | 1 |
| Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF | 1 |
| Kemmotsu, O; Nakata, F; Tanaka, R | 2 |
| Biros, MH; Dimlich, RV; Kaplan, J; Widman, DW | 1 |
| Kobashi, H; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Yokota, I | 1 |
| Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D | 1 |
| Abu Romen, S; Tannen, RL | 1 |
| Hashimoto, T; Hwang, TJ; Ito, M; Kuroda, Y; Masuda, M; Miyao, M; Naito, E; Takeda, E; Toshima, K; Yamashita, K | 1 |
| Barsan, WG; Eymer, V; Gin-Shaw, SL; Hedges, J | 1 |
| Xia, ZF | 1 |
| Egler, J; Ferraro, N; Mancini, DM; Wilson, JR | 1 |
| Bagby, GJ; Blakesley, HL; Lang, CH; Spitzer, JJ | 1 |
| Feldman, RL; Hill, JA; MacDonald, RG; Pepine, CJ; Stacpoole, PW; Wargovich, TJ | 1 |
| Harman, EM; Lorenz, AC; Stacpoole, PW; Thomas, RG | 1 |
| Morris, JG; Siegel, JH; Tall, BD; Vary, TC | 1 |
| Kinney, EL; Wright, RJ | 1 |
| Jawor, D; Morris, JG; Placko, R; Siegel, JH; Tall, BD; Vary, TC; Zechnich, A | 1 |
| Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Yokota, I | 1 |
| Fettman, MJ; Hand, MS; Phillips, RW; Weingand, KW | 2 |
| González-Rivero, J; Gualberto, A; Sobrino, F | 1 |
| Clark, AS; Curnow, RT; Fagan, JM; Goheer, MA; Goodman, MN; Mitch, WE | 1 |
| Iwashima, A; Kitagawa, K; Nishino, H | 1 |
| Biros, MH; Dimlich, RV | 1 |
| Cheema-Dhadli, S; Falk, N; Fields, AL; Halperin, ML | 1 |
| Barsan, WG; Dimlich, RV; Dronen, SC; Hedges, JR; Syverud, SA | 1 |
| Herren-Freund, SL; Khoury, MD; Olson, G; Pereira, MA | 1 |
| Barsan, WG; Dronen, SC; Syverud, SA; Timerding, B; Van Ligten, PF; Zink, BJ | 1 |
| Bodor, N; Gonzalez, MG; Oshiro, Y; Stacpoole, PW; Vlasak, J | 1 |
| Kuroda, Y; Matsuoka, S; Miyao, M; Miyauchi, Y; Naito, E; Nakatsu, T; Toshima, K | 1 |
| Mariash, CN; Schwartz, HL | 1 |
| Kamoshita, S; Kodama, H; Miyabayashi, S; Okabe, I; Shimoizumi, H | 1 |
| Kamoshita, S; Kodama, H; Kodama, M; Okabe, I; Orii, T; Yamaguchi, S | 1 |
| Biros, MH; Dimlich, RV; Kaplan, J | 1 |
| Davis, ME | 1 |
| Agius, L; Vaartjes, WJ | 1 |
| Radeck, W; Schadewaldt, P; Staib, W | 1 |
| Harding, GB; Thompson, LC; Ward, RA; Wathen, RL | 1 |
| Barsan, WG; Biros, MH; Dimlich, RV | 1 |
| Baumgartner, TG; Chu, PI; Curry, SH; Stacpoole, PW | 1 |
| Granot, H; Steiner, I | 1 |
| Slater, JH; Weightman, AJ; Weightman, AL | 1 |
| Arieff, AI; Graf, H; Leach, W | 1 |
| Cherrington, AD; Diamond, MP; Suhrer, JH; Williams, PE | 1 |
| Cherrington, AD; Diamond, MP; Lacy, WW; Suhrer, JH; Williams, PE | 1 |
| Caldecourt, MA; Palmer, TN; Sugden, MC | 1 |
| Arieff, AI; Park, R | 1 |
| Baudry, M; Kessler, M; Lynch, G; Smith, EK | 1 |
| Davidson, S; Mace, L; Shireman, RB | 1 |
| Enser, M; Whittington, FM | 1 |
| Casanello-Ertl, D; Duducgian-Vartavarian, L; Pardridge, WM | 1 |
| Aynsley-Green, A; Jenkins, PA; Ross, B; Soltész, G; Weindling, AM | 1 |
| Buc, HA; Demaugre, F; Leroux, JP; Saudubray, JM | 1 |
| Ito, M; Kobashi, H; Kuroda, Y; Miyao, M; Takeda, E; Toshima, K; Watanabe, T | 1 |
| Calabrese, EJ; Leonard, DA | 1 |
| Duff, DA; Snell, K | 1 |
| Evans, OB | 2 |
| Harwood, HJ; Stacpoole, PW; Varnado, CE | 1 |
| Agius, L; Sugden, MC; Watts, DI | 1 |
| Aynsley-Green, A; Jenkins, PA; Soltész, G; Weindling, AM | 1 |
| Abemayor, E; Haugaard, N; Kovachich, GB | 1 |
| Harris, RA; Paxton, R | 1 |
| Dierickx, PJ | 1 |
| Smith, RA; Yang, J | 1 |
| Hassinen, IE; Hiltunen, JK; Latipää, PM; Peuhkurinen, KJ | 1 |
| Arieff, AI; Leach, WJ; Park, R; Radosevich, PR; Seto, P | 1 |
| Baumgartner, TG; Curry, SH; Harman, EM; Misbin, RI; Stacpoole, PW | 1 |
| Buc, HA; Cepanec, C; Demaugre, F; Leroux, JP; Moncion, A | 1 |
| Hems, R | 1 |
| Hayek, A; Woodside, WF | 2 |
| Colman, N; Gardner, A; Herbert, V | 1 |
| Cherrington, AD; Diamond, MP; Erlendson, L; Lacy, WW; Rabin, D; Rollings, RC; Williams, PE | 1 |
| Crabb, DW; Harris, RA; Yount, EA | 1 |
| Buc, HA; Demaugre, F; Leroux, JP; Moncion, A | 1 |
| Brosnan, JT; Man, KC | 1 |
| Evans, OB; Stacpoole, PW | 2 |
| Felten, SY; Harris, RA; O'Connor, BL; Peterson, RG; Powell, RS; Yount, EA; Yum, MN | 1 |
| Felts, JM; Searle, GL; Shakelford, R | 1 |
| Campo, P; Dalstein, JM; Loubatières-Mariani, MM; Ribes, G | 1 |
| Harris, RA; Yount, EA | 1 |
| Diener, RM; Katz, R; McConnell, RF; Semonick, DE; Tai, CN | 1 |
| Hathway, DE | 1 |
| Goodman, MN; Komanicky, PM; Ruderman, NB; Schneider, SH | 1 |
| Dalstein, JM; Illy, N; Loubatières-Mariani, MM; Ribes, G | 1 |
| Cherrington, AD; Diamond, MP; Lacy, WW; Williams, PE | 1 |
| Halpert, J; Neal, RA | 1 |
| Harris, RA; Jolly, WW; Sans, RM | 2 |
| Grassl, SM; Merrill, GF; Zambraski, EJ | 1 |
| Brindle, SD; Le Sher, AR; Lukas, G; Vyas, KH; Wagner, WE | 1 |
| Merrill, GF; Rosolowsky, M | 1 |
| Moore, GW; Oates, JA; Rabin, D; Stacpoole, PW; Wells, PG; Wilkinson, GR | 1 |
| Glynn, RD; Hulter, HN; Sebastian, A | 1 |
| Bastianelli, P; Cannelli, B; Cingolani, ML; Salvucci, MP | 1 |
| Bruschi, SA; Bull, RJ | 1 |
| Austin, EW; Bull, RJ; Kinder, DH; Parrish, JM; Stevens, DK | 1 |
| Bull, RJ; Stevens, DK; Xu, G | 1 |
| Paul, CH; Royappa, AT | 1 |
| Abbas, R; Bishop, CT; Brashear, WT | 1 |
| Austin, EW; Bull, RJ | 1 |
| Erb, F; Giller, S; Le Curieux, F; Marzin, D | 1 |
| Borrull, F; Calull, M; Colom, A; Farré, J; Martínez, D; Ruana, J | 1 |
| Elfarra, AA; Krause, RJ; Lash, LH; Last, AR; Parker, JC | 1 |
| Boorman, GA | 1 |
| Anders, MW; Anderson, WB; Board, PG; Tzeng, HF; Wempe, MF | 1 |
| Heigenhauser, GJ; Howlett, RA; Spriet, LL | 1 |
| Galceran, MT; Santos, FJ; Sarrión, MN | 1 |
| Henderson, GN; James, MO; Stacpoole, PW; Yan, Z | 1 |
| Anders, MW; Blackburn, AC; Board, PG; Tzeng, HF | 1 |
| Bailey, K; Brooks, LR; DeAngelo, A; George, M; George, SE; Nelson, GM; Swank, AE | 1 |
| Ellis, DA; Fineberg, NA; Hanson, ML; Mabury, SA; Muir, DC; Shahid, T; Sibley, PK; Solomon, KR | 1 |
| Richard, AM; Swartz, PD | 1 |
| Anders, MW; Baggs, RB; Board, PG; Krenitsky, DM; Lantum, HB | 1 |
| Anders, MW; Board, PG; Lantum, HB | 1 |
| Anders, MW; Baggs, RB; Krenitsky, DM; Lantum, HB | 1 |
| Ding, MY; Haddad, PR; Hasebe, K; Helaleh, MI; Hu, W; Mori, M; Tanaka, K; Taoda, H; Xu, Q | 1 |
| DE MASI, C; GELLI, BR; RINI, U | 1 |
| DOLBERG, EB; IASNITSKII, BG; KOVALENKO, GI | 1 |
| Chappell, DJ; Enoki, A; Itakura, S; Slaytor, M; Tanaka, H | 1 |
| Krishnan, K; St-Pierre, A; Tardif, R | 1 |
| Andrews, JE; Hunter, ES; Klinefelter, GR; Mole, LM; Nichols, HP; Schmid, JE | 1 |
| Bastiaens, L; Borremans, B; Diels, L; Gemoets, J; Lookman, R; Maesen, M | 1 |
| Kramer, PK; Li, L; Pereira, MA; Tao, L; Wang, W | 1 |
| Barra, R; Bootsma, HA; Johnston, AE; Jones, KC; Martin, JW; Muir, DC; Scott, BF; Spencer, C | 1 |
| Andrews, J; Blanton, MR; Chernoff, N; Hunter, ES; Leonard Mole, M; Rogers, EH | 1 |
| Ansari, GA; Cai, P; Kaphalia, BS; Khan, MF; König, R; Qiu, S | 1 |
| Gu, P; Huang, J; Sun, Y | 1 |
| Kim, J | 1 |
| Chang, SN; Chen, CY; Wang, GS | 1 |
| Kanlayaprasit, C; Khaodhiar, S; Ngamcharussrivichai, C; Punyapalakul, P; Soonglerdsongpha, S | 1 |
| Dringen, R; Rohwedder, A; Schmidt, MM | 1 |
| Pereira, Rde S | 1 |
| Cardador, MJ; Gallego, M | 1 |
| Brillas, E; Randazzo, S; Scialdone, O; Sirés, I | 1 |
| Gao, NY; Li, DP; Qin, C; Tian, FX; Xia, SJ; Xu, B; Xu, Q | 1 |
| Littlechild, JA; Novak, HR; Panning, J; Sayer, C | 1 |
| Her, GR; Hung, SH | 1 |
| Liu, B; Reckhow, DA | 1 |
| Mao, YQ; Tang, S; Wang, XM; Xie, YF; Yang, HW; Zhao, Y | 1 |
| Chen, L; Luo, X; Zhao, Y | 1 |
| Faria, MA; Ferreira, IMPLVO; Mansilha, C; Melo, A; Pinto, E | 1 |
| Evans, A; Kaufman, JA; Meyer, A; Narotsky, MG; Rivera-Núñez, Z; Wright, JM | 1 |
| Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA | 1 |
| da Silva Faria, MC; Franco, ES; Maia, LFO; Mourão, AO; Pádua, VL; Rodrigues, JL; Rodriguez, M; Silva, DF; Torres, TS | 1 |
| Gong, T; Wang, J; Xian, Q | 1 |
| Huo, Y; Liu, Z; Peng, J; Wu, J; Zhang, Z | 1 |
| Bertelsen, LB; Bøgh, N; Hansen, ESS; Laustsen, C; Miller, J; Ringgaard, S; Wohlfart, P | 1 |
| Alonso, MM; Balnytė, I; Damanskienė, E; Lesauskaitė, V; Stakišaitis, D; Valančiūtė, A | 1 |
5 review(s) available for phenyl acetate and dichloroacetic acid
| Article | Year |
|---|---|
[Sodium dichloroacetate--a substance with manifold therapeutic potential].
Topics: Acetates; Animals; Dichloroacetic Acid; Enzyme Activation; Humans; Pyruvate Dehydrogenase Complex | 1990 |
The pharmacology of dichloroacetate.
Topics: Acetates; Amino Acids; Animals; Carbohydrate Metabolism; Chemical Phenomena; Chemistry, Physical; Dichloroacetic Acid; Hemodynamics; Humans; Kidney; Lactates; Lactic Acid; Lipid Metabolism; Lipoproteins; Neurons; Peripheral Nervous System Diseases; Proteins | 1989 |
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Food; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains | 1989 |
The metabolic effects of dichloroacetate.
Topics: Acetates; Adipose Tissue; Amino Acids, Branched-Chain; Animals; Carbohydrate Metabolism; Diabetes Mellitus; Dichloroacetic Acid; Enzyme Activation; Ethanol; Gluconeogenesis; Humans; Hyperlipidemias; Kidney; Lactates; Lipid Metabolism; Liver; Muscles; Myocardium; Nervous System; Pyruvate Dehydrogenase Complex; Rats | 1981 |
Drinking water disinfection byproducts: review and approach to toxicity evaluation.
Topics: Acetates; Animals; Chloroform; Dichloroacetic Acid; Disinfection; DNA Damage; Fishes; Humans; Hydrocarbons, Brominated; Mice; Ozone; Trichloroacetic Acid; Trihalomethanes; Water Supply | 1999 |
3 trial(s) available for phenyl acetate and dichloroacetic acid
| Article | Year |
|---|---|
Effect of dichloroacetate on lactate concentration in exercising humans.
Topics: Acetates; Adult; Dichloroacetic Acid; Humans; Lactates; Lactic Acid; Male; Models, Biological; Models, Theoretical; Oxygen Consumption; Physical Exertion; Pyruvate Dehydrogenase Complex | 1989 |
Effect of dichloroacetate on the exercise performance of patients with heart failure.
Topics: Acetates; Acidosis, Lactic; Adult; Aged; Dichloroacetic Acid; Exercise; Fatigue; Heart Failure; Humans; Lactates; Lactic Acid; Leg; Male; Middle Aged; Muscles; Oxygen Consumption; Regional Blood Flow | 1988 |
Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion.
Topics: Acetates; Acetyl Coenzyme A; Acetylation; Acetylcarnitine; Adenosine Triphosphate; Adult; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Ergometry; Exercise; Female; Humans; Male; Muscle, Skeletal; Oxidation-Reduction; Oxygen Consumption; Pyruvate Dehydrogenase Complex; Rest; Running | 1999 |
196 other study(ies) available for phenyl acetate and dichloroacetic acid
| Article | Year |
|---|---|
[Actions of sodium dichloroacetate in combination with insulin on hyperlactatemia and hyperpyruvicemia induced in dogs by phenformin].
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Dogs; Hydrogen-Ion Concentration; Insulin; Lactates; Phenformin; Pyruvates | 1977 |
[Sodium dichloracetate: its application to the therapeutics of experimental hyperiactatemia (author's transl)].
Topics: Acetates; Animals; Blood; Dichloroacetic Acid; Dogs; Hydrogen-Ion Concentration; Hypoxia; Lactates; Phenformin; Pyruvates | 1978 |
Dichloracetate in biguanide-induced lacticacidosis.
Topics: Acetates; Aged; Animals; Biguanides; Buformin; Diabetes Mellitus; Diabetic Ketoacidosis; Dichloroacetic Acid; Drug Evaluation; Female; Humans; Lactates; Rats | 1977 |
Dichloroacetate in biguanide-induced lacticacidosis.
Topics: Acetates; Animals; Buformin; Diabetic Ketoacidosis; Dichloroacetic Acid; Drug Evaluation; Humans; Lactates | 1977 |
Metabolic effects of sodium dichloroacetate in normal and diabetic dogs.
Topics: Acetates; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Dichloroacetic Acid; Dogs; Hydroxybutyrates; Insulin; Lactates; Oxaloacetates; Pyruvates; Triglycerides | 1979 |
[Effects of thiamine pyrophosphate and sodium dichloroacetate on the increase of lactate and insulin outputs induced by phenformin on the isolated and perfused rat pancreas].
Topics: Acetates; Animals; Dichloroacetic Acid; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lactates; Pancreas; Phenformin; Pyruvates; Rats; Thiamine Pyrophosphate | 1977 |
Toxicity of chronic dichloroacetate.
Topics: Acetates; Administration, Oral; Adult; Animals; Dichloroacetic Acid; Dogs; Humans; Male; Peripheral Nervous System Diseases; Rats; Time Factors | 1979 |
[The effect of combined therapy with buformin and dichloracetate on blood lactate concentrations in diabetics].
Topics: Acetates; Aged; Biguanides; Buformin; Diabetes Mellitus; Diabetic Ketoacidosis; Dichloroacetic Acid; Drug Therapy, Combination; Exercise Test; Fasting; Female; Humans; Lactates; Male; Middle Aged; Pyruvates | 1977 |
Effects of dichloroacetate on lipid metabolism in isolated rat liver cells.
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Fatty Acids, Nonesterified; Glucose; In Vitro Techniques; Ketone Bodies; Lipids; Liver; Male; Phospholipids; Protein Biosynthesis; Rats; Triglycerides | 1979 |
Reduction of serum cholesterol in two patients with homozygous familial hypercholesterolemia by dichloroacetate.
Topics: Acetates; Acrodynia; Adult; Child; Cholesterol; Dichloroacetic Acid; Humans; Hypercholesterolemia; Male; Xanthomatosis | 1979 |
Mechanism responsible for the hypoglycemic actions of dichloroacetate and 2-chloropropionate.
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Dihydroxyacetone; Fasting; Gluconeogenesis; Glyoxylates; Hydrocarbons, Chlorinated; In Vitro Techniques; Ketone Bodies; Lactates; Liver; Male; Oxalates; Propionates; Pyruvates; Rats | 1979 |
Treament of biguanide-induced lactic acidosis with dichloroacetate. 3 case histories.
Topics: Acetates; Acidosis; Aged; Biguanides; Dichloroacetic Acid; Female; Humans; Lactates; Male; Middle Aged | 1979 |
Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia.
Topics: Acetates; Acidosis; Adult; Aged; Alanine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus; Dichloroacetic Acid; Female; Humans; Hyperlipidemias; Ketone Bodies; Lactates; Male; Middle Aged; Triglycerides | 1978 |
Lactic acidosis and a possible new treatment.
Topics: Acetates; Acidosis; Animals; Depression, Chemical; Dichloroacetic Acid; Dogs; Humans; Lactates | 1978 |
Studies on the regulation of leucine catabolism in the liver. Stimulation by pyruvate and dichloroacetate.
Topics: Acetates; Animals; Carbohydrates; Dichloroacetic Acid; In Vitro Techniques; Kinetics; Leucine; Liver; Male; Pyruvates; Rats | 1978 |
Comparison of the actions of dichloroacetate and 2-bromopalmitate in palmitate-perfused rat hearts: effects on carbohydrate metabolism, contractility and oxygen consumption [proceedings].
Topics: Acetates; Animals; Carbohydrate Metabolism; Dichloroacetic Acid; Heart; Heart Rate; Myocardial Contraction; Myocardium; Oxygen Consumption; Palmitic Acids; Perfusion; Rats | 1978 |
Inhibition of lactate glucogneogenesis in rat kidney by dichloroacetate.
Topics: Acetates; Adenine Nucleotides; Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Gluconeogenesis; In Vitro Techniques; Kidney; Kidney Cortex; Lactates; Male; Mitochondria; Pyruvate Dehydrogenase Complex; Pyruvates; Rats; Starvation | 1978 |
Biosynthesis of chloramphenicol. Studies on the origin of the dichloroacetyl moiety.
Topics: Acetates; Carbon Radioisotopes; Chloramphenicol; Coenzyme A; Dichloroacetic Acid; Streptomyces | 1978 |
Dichloroacetate and the treatment of lactic acidosis.
Topics: Acetates; Acidosis; Bicarbonates; Dichloroacetic Acid; Humans; Lactates | 1978 |
Metabolic effects of dichloroacetate.
Topics: Acetates; Animals; Dichloroacetic Acid; Fatty Acids; Gluconeogenesis; Leucine; Oxalates; Rats | 1978 |
Dichloroacetate.
Topics: Acetates; Acidosis; Dichloroacetic Acid; Humans | 1978 |
Inhibition of hepatic gluconeogenesis by dichloroacetate.
Topics: Acetates; Acetoacetates; Animals; Aspartic Acid; Buffers; Dichloroacetic Acid; Ethanol; Gluconeogenesis; Hydroxybutyrates; Lactates; Liver; Lysine; Malates; Male; Pyruvate Dehydrogenase Complex; Pyruvates; Rats | 1978 |
Studies on the regulation of leucine catabolism. II. Mechanism responsible for dichloroacetate stimulation of leucine oxidation by the liver.
Topics: Acetates; Amino Acids; Animals; Carboxylic Acids; Dichloroacetic Acid; In Vitro Techniques; Kinetics; Leucine; Liver; Male; Oxidation-Reduction; Rats | 1978 |
Dichloroacetate as treatment for congenital lactic acidosis.
Topics: Acetates; Acidosis; Dichloroacetic Acid; Humans; Infant; Lactates; Male; Pyruvates | 1978 |
Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids; Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Female; Glucose; Glycerol; Insulin; Lactates; Muscles; Perfusion; Pyruvates; Rats; Starvation | 1978 |
The metabolic effects of sodium dichloroacetate in the suckling newborn rat.
Topics: Acetates; Animals; Animals, Newborn; Blood Glucose; Dichloroacetic Acid; Gluconeogenesis; Hypoglycemia; Ketosis; Rats; Sodium | 1978 |
Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells.
Topics: Acetates; Animals; Dichloroacetic Acid; Fasting; Gluconeogenesis; In Vitro Techniques; Kinetics; Liver; Mitochondria, Liver; Oxalates; Pyruvate Carboxylase; Pyruvates; Rats | 1978 |
[Effect of dichloracetate on elevated blood lactate levels in biguanide treated diabetics].
Topics: Acetates; Biguanides; Diabetes Mellitus; Dichloroacetic Acid; Humans; Lactates | 1978 |
The metabolic effects of sodium dichloroacetate in experimental hepatitis in the rat [proceedings].
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Fructose; Galactosamine; Hepatitis, Animal; Ketone Bodies; Lactates; Rats | 1977 |
Sex differences in monochloroacetate pretreatment effects on chloroform toxicity in rats.
Topics: Acetates; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Chloroform; Dichloroacetic Acid; Female; Kidney Diseases; Kidney Function Tests; Liver Function Tests; Male; Potassium; Rats; Rats, Inbred Strains; Sex Characteristics; Sodium; Trichloroacetic Acid | 1992 |
Densitometric analysis of cytochrome oxidase in ischemic rat brain.
Topics: Acetates; Animals; Brain; Cobalt; Dichloroacetic Acid; Electron Transport Complex IV; Ischemic Attack, Transient; Male; Rats; Rats, Inbred Strains; Staining and Labeling | 1990 |
Ninety day toxicity study of chloroacetic acids in rats.
Topics: Acetates; Animals; Body Weight; Brain; Dichloroacetic Acid; Lethal Dose 50; Liver; Lung; Male; Rats; Rats, Inbred Strains; Testis; Trichloroacetic Acid | 1991 |
Dichloroacetate administration in the treatment of endotoxin shock.
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Drug Evaluation; Endotoxins; Escherichia coli Infections; Hemodynamics; Lactose; Oxygen Consumption; Shock, Septic | 1990 |
Chronic toxicity of dichloroacetate: possible relation to thiamine deficiency in rats.
Topics: Acetates; Animals; Body Weight; Dichloroacetic Acid; Erythrocytes; Male; Oxalates; Rats; Rats, Inbred Strains; Thiamine Deficiency; Time Factors; Transketolase | 1990 |
Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate.
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Ischemia; Rabbits; Spinal Cord | 1990 |
Neurological protection by dichloroacetate depending on the severity of injury in the paraplegic rat.
Topics: Acetates; Animals; Brain Ischemia; Citric Acid Cycle; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glycolysis; Hyperglycemia; Iodoacetates; Male; Paraplegia; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Spinal Cord Injuries | 1990 |
[Effects of dichloroacetate in the ischemic heart. Analysis of hemodynamics, myocardial energy metabolism and myocardial pH].
Topics: Acetates; Adenine Nucleotides; Animals; Coronary Disease; Dichloroacetic Acid; Dogs; Energy Metabolism; Glycolysis; Hemodynamics; Hydrogen-Ion Concentration; Myocardium; Phosphocreatine | 1990 |
Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats.
Topics: Acetates; Adenosine Triphosphate; Amrinone; Animals; Cardiac Output; Dichloroacetic Acid; Drug Interactions; Glucose; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Ouabain; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Shock, Septic; Systole | 1988 |
Lactate-lowering effect of dichloroacetic acid: a model for investigation of anxiolytic drugs?
Topics: Acetates; Anti-Anxiety Agents; Dichloroacetic Acid; Drug Evaluation, Preclinical; Humans; Lactates; Models, Biological | 1989 |
Lactate formation and tissue hypoxia.
Topics: Acetates; Dichloroacetic Acid; Exercise; Humans; Hypoxia; Lactates | 1989 |
Effect of dichloroacetate on plasma and hepatic amino acids in sterile inflammation and sepsis.
Topics: Abscess; Acetates; Amino Acids; Animals; Bacteroides Infections; Dichloroacetic Acid; Escherichia coli Infections; Liver; Male; Peritonitis; Rats; Rats, Inbred Strains | 1989 |
Effect of dichloroacetate on regional energy metabolites and pyruvate dehydrogenase activity during ischemia and reperfusion in gerbil brain.
Topics: Acetates; Animals; Behavior, Animal; Brain; Brain Ischemia; Dichloroacetic Acid; Energy Metabolism; Gerbillinae; Pyruvate Dehydrogenase Complex; Reperfusion; Time Factors | 1989 |
Developmental toxicity of dichloroacetonitrile: a by-product of drinking water disinfection.
Topics: Acetates; Animals; Dichloroacetic Acid; Female; Fetus; Pregnancy; Pregnancy, Animal; Rats; Reproduction; Water Supply | 1989 |
The effect of dichloroacetate on the isolated no flow arrested rat heart.
Topics: Acetates; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dichloroacetic Acid; In Vitro Techniques; Lactates; Male; Myocardial Contraction; Myocardium; Phosphocreatine; Pyruvate Dehydrogenase Complex; Rats | 1989 |
Effect of sodium dichloroacetate on human pyruvate metabolism.
Topics: Acetates; Acidosis, Lactic; Adolescent; Blood Platelets; Dichloroacetic Acid; Humans; Male; Muscular Diseases; Pyruvates; Pyruvic Acid | 1989 |
Dichloroacetic acid and trichloroacetic acid-induced DNA strand breaks are independent of peroxisome proliferation.
Topics: Acetates; Animals; Dichloroacetic Acid; DNA; DNA Damage; Kinetics; Liver; Male; Mice; Microbodies; Microscopy, Electron; Organ Size; Oxidation-Reduction; Palmitoyl Coenzyme A; Trichloroacetic Acid | 1989 |
[Dose dependent effects of dichloroacetate on lactic acidosis in dogs].
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Dose-Response Relationship, Drug; Injections, Intravenous | 1989 |
Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids.
Topics: Acetates; Animals; Body Weight; Carcinogens; Carnitine O-Acetyltransferase; Corn Oil; Dichloroacetic Acid; Electrophoresis, Polyacrylamide Gel; Liver; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microbodies; Organ Size; Pharmaceutical Vehicles; Rats; Rats, Inbred F344; Species Specificity; Trichloroacetic Acid; Water | 1989 |
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Humans; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains | 1989 |
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Sodium; Sodium Bicarbonate | 1987 |
Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat.
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Blood Glucose; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Glycogen; Lactates; Male; Rats; Rats, Inbred Strains; Resuscitation; Sodium; Sodium Bicarbonate | 1988 |
Detection of pyruvate metabolism disorders by culture of skin fibroblasts with dichloroacetate.
Topics: Acetates; Acidosis, Lactic; Cells, Cultured; Child; Dichloroacetic Acid; Enzyme Activation; Female; Fibroblasts; Humans; Infant; Male; Mitochondria; Phosphoprotein Phosphatases; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid | 1988 |
Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs.
Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart Arrest; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Models, Biological; Oxygen; Resuscitation; Sodium; Sodium Bicarbonate | 1986 |
Therapeutic benefit of dichloroacetate in experimentally induced hypoxic lactic acidosis.
Topics: Acetates; Acidosis; Animals; Blood Pressure; Carbon Dioxide; Dichloroacetic Acid; Hypoxia; Kinetics; Lactates; Male; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains | 1986 |
Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate.
Topics: Acetates; Acidosis; Adolescent; Brain; Dichloroacetic Acid; Humans; Infant, Newborn; Kidney; Lactates; Lactic Acid; Liver; Male; Muscles; Neuromuscular Diseases | 1986 |
Effects of dichloroacetate following canine asphyxial arrest.
Topics: Acetates; Acidosis, Lactic; Animals; Asphyxia; Blood Glucose; Blood Pressure; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart Arrest; Hydrogen-Ion Concentration; Lactates; Pulse; Resuscitation | 1988 |
[Effects of F.D.P. and D.C.A. on myocardial energy metabolism and intracellular pH of hearts of severely burned rats].
Topics: Acetates; Acidosis; Animals; Burns; Dichloroacetic Acid; Energy Metabolism; Fructosediphosphates; Hexosediphosphates; Male; Myocardium; Rats; Rats, Inbred Strains | 1988 |
Glucose kinetics and pyruvate dehydrogenase activity in septic rats treated with dichloroacetate.
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Escherichia coli Infections; Fever; Hemodynamics; Injections, Intravenous; Insulin; Liver; Male; Muscles; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Sepsis | 1987 |
Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease.
Topics: Acetates; Aged; Cardiac Catheterization; Coronary Disease; Dichloroacetic Acid; Female; Heart; Hemodynamics; Humans; Lactates; Male; Middle Aged | 1988 |
Dichloroacetate in the treatment of lactic acidosis.
Topics: Acetates; Acidosis, Lactic; Adolescent; Adult; Aged; Dichloroacetic Acid; Female; Hemodynamics; Humans; Infant; Infant, Newborn; Male; Middle Aged; Prospective Studies | 1988 |
Metabolic effects of partial reversal of pyruvate dehydrogenase activity by dichloroacetate in sepsis.
Topics: Abscess; Acetates; Animals; Bacterial Infections; Dichloroacetic Acid; Inflammation; Lactates; Liver; Male; Muscles; Pyruvate Dehydrogenase Complex; Pyruvates; Rats; Rats, Inbred Strains | 1988 |
Dichloroacetate and lactic acidosis.
Topics: Acetates; Acidosis, Lactic; Adult; Algorithms; Animals; Dichloroacetic Acid; Horses; Humans | 1988 |
Pharmacological reversal of abnormal glucose regulation, BCAA utilization, and muscle catabolism in sepsis by dichloroacetate.
Topics: Acetates; Amino Acids, Branched-Chain; Animals; Bacterial Infections; Blood Glucose; Dichloroacetic Acid; Glucose; Kinetics; Male; Muscles; Rats; Rats, Inbred Strains | 1988 |
Congenital lactic acidosis.
Topics: Acetates; Acidosis, Lactic; Adolescent; Decarboxylation; Dichloroacetic Acid; Humans; Lactates; Male; Pyruvates | 1987 |
Effects of sodium dichloroacetate in awake, healthy, Yucatan miniature swine.
Topics: Acetates; Animals; Blood Glucose; Blood Pressure; Body Temperature; Dichloroacetic Acid; Infusions, Parenteral; Insulin; Insulin Secretion; Islets of Langerhans; Liver Circulation; Regional Blood Flow; Skin Temperature; Swine; Swine, Miniature; Wakefulness | 1986 |
Metabolic effects of sodium dichloroacetate in endotoxemic minipigs.
Topics: Acetates; Animals; Blood Glucose; Blood Pressure; Dichloroacetic Acid; Escherichia coli; Insulin; Islets of Langerhans; Lactates; Lipopolysaccharides; Liver Circulation; Male; Shock, Septic; Swine; Swine, Miniature; Tritium | 1986 |
Regulation of fructose-2,6-bisphosphate and glycogen synthesis by dichloroacetate and phenazine methosulphate in rat adipose tissue.
Topics: Acetates; Adipose Tissue; Animals; Dichloroacetic Acid; Epididymis; Fructosediphosphates; Glycogen; Hexosediphosphates; Insulin; Kinetics; Male; Methylphenazonium Methosulfate; Phenazines; Rats; Rats, Inbred Strains | 1986 |
Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle.
Topics: Acetates; Animals; Biological Transport, Active; Dichloroacetic Acid; Glucose; Glycogen; Glycolysis; In Vitro Techniques; Insulin; Kinetics; Lactates; Male; Muscles; Rats; Rats, Inbred Strains | 1987 |
Insulin-like effect of dichloroacetic acid on hexose transport in Swiss 3T3 cells.
Topics: 3-O-Methylglucose; Acetates; Animals; Biological Transport; Calcium; Cell Line; Dichloroacetic Acid; Glucose; Hexoses; Insulin; Magnesium; Methylglucosides; Mice | 1987 |
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia].
Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid | 1986 |
Brain lactate during partial global ischemia and reperfusion: effect of pretreatment with dichloroacetate in a rat model.
Topics: Acetates; Animals; Blood Glucose; Brain; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Dichloroacetic Acid; Glucose; Glycogen; Lactates; Male; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Accelerated loss of lean body mass in fasting rats due to activation of pyruvate dehydrogenase by dichloroacetate.
Topics: Acetates; Animals; Body Weight; Dichloroacetic Acid; Enzyme Activation; Fasting; Liver; Male; Nitrogen; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred BUF | 1987 |
Effects of dichloroacetate in spinal stroke in the rabbit.
Topics: Acetates; Animals; Blood Glucose; Cerebrovascular Disorders; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Movement; Rabbits; Spinal Cord; Spinal Cord Diseases; Time Factors | 1987 |
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
Topics: Acetates; Adenoma; Animals; Body Weight; Dichloroacetic Acid; Drug Synergism; Ethylnitrosourea; Liver Neoplasms, Experimental; Male; Mice; Organ Size; Phenobarbital; Trichloroacetic Acid; Trichloroethylene | 1987 |
Effects of dichloroacetate administration during fatal hemorrhagic shock in immature swine.
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Female; Lactates; Shock, Hemorrhagic; Swine | 1987 |
Dichloroacetate derivatives. Metabolic effects and pharmacodynamics in normal rats.
Topics: Acetates; Animals; Biological Availability; Blood Glucose; Chloroacetates; Cholesterol; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triglycerides; Tritium; Water | 1987 |
Effects of dichloroacetate on the mechanical function of the isolated ischemic heart.
Topics: Acetates; Animals; Dichloroacetic Acid; Enzyme Activation; Heart; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardium; Perfusion; Pyruvate Dehydrogenase Complex; Rats | 1987 |
Effect of dichloroacetic acid on rat hepatic messenger RNA activity profiles.
Topics: Acetates; Animals; Blood Glucose; Body Weight; Dichloroacetic Acid; In Vitro Techniques; Liver; Malate Dehydrogenase; Male; Pyruvates; Rats; Rats, Inbred Strains; RNA, Messenger | 1986 |
Treatment of lactic acidosis: effects of dichloroacetate on lactate and pyruvate levels in the cerebrospinal fluid.
Topics: Acetates; Acidosis; Administration, Oral; Dichloroacetic Acid; Fibroblasts; Humans; Infant; Lactates; Leigh Disease; Male; Pyruvates | 1986 |
Renal effects of dichloroacetate in vivo.
Topics: Acetates; Acidosis, Lactic; Administration, Oral; Child, Preschool; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Humans; Kidney; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid | 1986 |
Dichloroacetate treatment of ischemic cerebral lactic acidosis in the fed rat.
Topics: Acetates; Acidosis, Lactic; Animals; Blood Glucose; Blood Pressure; Brain Ischemia; Dichloroacetic Acid; Food; Hematocrit; Lactates; Male; Rats; Rats, Inbred Strains | 1987 |
Effect of chloroacetic acids on the kidneys.
Topics: Acetates; Acidosis; Animals; Dichloroacetic Acid; Disinfectants; Female; Glucose; Kidney; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Trichloroacetic Acid; Water Supply | 1986 |
Effect of insulin on ketogenesis and fatty acid synthesis in rat hepatocytes incubated with dichloroacetate.
Topics: Acetates; Acetyl Coenzyme A; Animals; Carbon Dioxide; Citrates; Citric Acid; Dichloroacetic Acid; Enzyme Activation; Fatty Acids; Female; Insulin; Ketone Bodies; Liver; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
Differential effect of dichloroacetate on branched-chain amino acid catabolism in perfused rat hindlimbs.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acetates; Amino Acids, Branched-Chain; Animals; Carbon Dioxide; Dichloroacetic Acid; Hindlimb; Ketone Oxidoreductases; Leucine; Multienzyme Complexes; Muscles; Pyruvates; Pyruvic Acid; Rats; Valine | 1985 |
Comparative metabolic effects of acetate and dichloroacetate infusion in the anesthetized dog.
Topics: Acetates; Alanine; Animals; Bicarbonates; Blood Glucose; Carbon Dioxide; Dichloroacetic Acid; Dogs; Electrolytes; Fasting; Fatty Acids; Hydrogen-Ion Concentration; Insulin; Lactates; Oxygen; Phosphates; Pyruvates | 1985 |
Postinsult treatment of ischemia-induced cerebral lactic acidosis in the rat.
Topics: Acetates; Acidosis; Animals; Blood Glucose; Blood Pressure; Brain; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Electroencephalography; Glucose; Glycogen; Hydrogen-Ion Concentration; Lactates; Male; Rats; Rats, Inbred Strains | 1986 |
Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate.
Topics: Acetates; Adult; Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parenteral; Kinetics; Lactates; Lactic Acid; Male; Middle Aged; Oxalates; Oxalic Acid; Rats | 1985 |
Successful treatment of irreversible hemorrhagic shock in dogs with fructose-1,6 diphosphate and dichloroacetate.
Topics: Acetates; Animals; Body Temperature; Dichloroacetic Acid; Dogs; Female; Fructosediphosphates; Hemodynamics; Hexosediphosphates; Lactates; Male; Oxygen Consumption; Shock, Hemorrhagic | 1985 |
Toxic effects of chlorinated and brominated alkanoic acids on Pseudomonas putida PP3: selection at high frequencies of mutations in genes encoding dehalogenases.
Topics: Acetates; Dichloroacetic Acid; Gene Expression Regulation; Genes, Bacterial; Hydrolases; Mutation; Phenotype; Pseudomonas; Selection, Genetic | 1985 |
Effects of dichloroacetate in the treatment of hypoxic lactic acidosis in dogs.
Topics: Acetates; Acid-Base Equilibrium; Acidosis; Animals; Dichloroacetic Acid; Dogs; Female; Hemodynamics; Hydrogen-Ion Concentration; Intracellular Fluid; Lactates; Liver; Male; Muscles; Oxygen Consumption; Sodium Chloride | 1985 |
Dichloroacetate: direct inhibitor of lipolysis in the conscious dog.
Topics: Acetates; Animals; Dichloroacetic Acid; Dogs; Fasting; Fatty Acids, Nonesterified; Female; Glycerol; Lipolysis; Liver; Male; Somatostatin | 1982 |
Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog.
Topics: Acetates; Alanine; Animals; Dichloroacetic Acid; Dogs; Epinephrine; Glucagon; Glucose; Hypoglycemia; Insulin; Lactates; Liver; Norepinephrine; Somatostatin | 1982 |
Treatment of lacticacidosis with dichloroacetate.
Topics: Acetates; Acidosis; Animals; Child; Dichloroacetic Acid; Dogs; Humans; Lactates; Rats | 1983 |
Amino acid oxidation and alanine production in rat hemidiaphragm in vitro. Effects of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids; Animals; Aspartic Acid; Diaphragm; Dichloroacetic Acid; Glucose; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Muscles; Oxidation-Reduction; Rats; Rats, Inbred Strains; Starvation | 1984 |
Treatment of lactic acidosis with dichloroacetate in dogs.
Topics: Acetates; Acidosis; Animals; Bicarbonates; Cardiac Output; Dichloroacetic Acid; Dogs; Female; Hepatectomy; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Phenformin; Sodium Bicarbonate; Sodium Chloride | 1982 |
The regulation of pyruvate dehydrogenase activity in rat hippocampal slices: effect of dichloroacetate.
Topics: Acetates; Animals; Dichloroacetic Acid; Hippocampus; Male; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; Pyruvate Dehydrogenase Complex; Pyruvate Kinase; Rats; Rats, Inbred Strains | 1982 |
Effects of dichloroacetate and glyoxylate on low density lipoprotein uptake and on growth of cultured fibroblasts.
Topics: Acetates; Biological Transport; Cell Division; Cell Line; Cell Membrane; Dichloroacetic Acid; Fibroblasts; Glyoxylates; Humans; Kinetics; Lipoproteins, LDL; Receptors, Cell Surface; Receptors, LDL; Skin | 1984 |
The actions of dichloroacetic acid on blood glucose, liver glycogen and fatty acid synthesis in obese-hyperglycaemic (ob/ob) and lean mice.
Topics: Acetates; Adipose Tissue; Animals; Blood Glucose; Dichloroacetic Acid; Fatty Acids; Female; Hyperglycemia; Insulin; Lactates; Lactic Acid; Liver Glycogen; Mice; Obesity | 1983 |
Effects of dichloroacetate on the lactate/pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells.
Topics: Acetates; Animals; Aspartic Acid; Carbon Dioxide; Cells, Cultured; Culture Media; Dichloroacetic Acid; Lactates; Lactic Acid; Leucine; Male; Muscles; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Dichloroacetate in the treatment of congenital lactic acidosis.
Topics: Acetates; Acidosis; Dichloroacetic Acid; Humans; Infant; Lactates; Male; Pyruvates | 1984 |
[Effects of dichloroacetate and 2-chloropropionate on carbohydrate metabolism of isolated hepatocytes. Therapeutic applications].
Topics: Acetates; Acidosis; Animals; Carbohydrate Metabolism; Dichloroacetic Acid; Glucose; History, 20th Century; Hydrocarbons, Chlorinated; In Vitro Techniques; Liver; Methods; Propionates; Pyruvate Carboxylase; Rats | 1980 |
Effects of dichloroacetate on pyruvate metabolism in rat brain in vivo.
Topics: Acetates; Animals; Blood Glucose; Brain; Dichloroacetic Acid; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Lactates; Lactic Acid; Liver; Male; Muscles; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
The effects of di- and trichloroacetic acid on sheep erythrocytes: an animal model with a glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetates; Animals; Dichloroacetic Acid; Disease Models, Animal; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency; In Vitro Techniques; Methemoglobinemia; Sheep; Trichloroacetic Acid | 1984 |
Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids, Branched-Chain; Animals; Dichloroacetic Acid; In Vitro Techniques; Male; Muscles; Rats; Rats, Inbred Strains; Starvation | 1984 |
Effects of dichloroacetate on brain tissue pyruvate dehydrogenase.
Topics: Acetates; Adenosine Triphosphate; Animals; Brain; Dichloroacetic Acid; Enzyme Activation; Ketoglutaric Acids; Malates; Mitochondria; Mitochondria, Liver; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Succinates; Succinic Acid | 1983 |
Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids on enzyme activity.
Topics: Acetates; Animals; Cholesterol; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glyoxylates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Male; Microsomes, Liver; Oxalates; Oxalic Acid; Rats; Rats, Inbred Strains | 1983 |
Effects of dichloroacetate on fatty acid synthesis in interscapular brown adipose tissue of the rat in vivo and in vitro.
Topics: Acetates; Adipose Tissue, Brown; Animals; Dichloroacetic Acid; Fatty Acids; Female; Glucose; Lactates; Lactic Acid; Lipids; Rats; Rats, Inbred Strains; Starvation | 1983 |
Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA).
Topics: Acetates; Acidosis; Alanine; Diazoxide; Dichloroacetic Acid; Humans; Hypoglycemia; Infant; Infant, Newborn; Lactates; Male | 1983 |
Effects of dichloroacetate on brain pyruvate dehydrogenase.
Topics: Acetates; Animals; Brain; Dichloroacetic Acid; Glucose; Male; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart.
Topics: Acetates; Animals; Clofibrate; Clofibric Acid; Dichloroacetic Acid; Enzyme Activation; In Vitro Techniques; Male; Myocardium; Perfusion; Phenylpyruvic Acids; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Rats; Rats, Inbred Strains | 1984 |
In vitro binding of acetic acid and its chlorinated derivatives by the soluble glutathione S-transferases from rat liver.
Topics: Acetates; Acetic Acid; Animals; Dichloroacetic Acid; Glutathione Transferase; In Vitro Techniques; Isoenzymes; Liver; Protein Binding; Rats; Trichloroacetic Acid | 1984 |
The effect of dichloroacetate on the phosphorylation of mitochondria proteins.
Topics: Acetates; Animals; Brain; Coenzyme A Ligases; Dichloroacetic Acid; Female; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Phosphoproteins; Phosphorylation; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Succinate-CoA Ligases | 1983 |
Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate.
Topics: Acetates; Animals; Caprylates; Dichloroacetic Acid; Enzyme Activation; Fatty Acids; Male; Myocardium; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Rats; Rats, Inbred Strains | 1983 |
Metabolic effects of dichloroacetate in diabetic dogs.
Topics: Acetates; Amino Acids; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Dogs; Gluconeogenesis; Kinetics; Liver; Liver Circulation; Male; Muscles; Pancreatectomy | 1983 |
Treatment of lactic acidosis with dichloroacetate.
Topics: 3-Hydroxybutyric Acid; Acetates; Acidosis; Adolescent; Adult; Aged; Alanine; Bicarbonates; Blood Pressure; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Lactates; Lactic Acid; Male; Middle Aged | 1983 |
Comparison of the effects of 2-chloropropionate and dichloroacetate on ketogenesis and lipogenesis in isolated rat hepatocytes.
Topics: Acetates; Animals; Dichloroacetic Acid; Drug Interactions; Hydrocarbons, Chlorinated; In Vitro Techniques; Ketone Bodies; Ketones; Lipids; Liver; Male; Oxalates; Propionates; Pyruvates; Rats; Rats, Inbred Strains | 1983 |
The effect of dichloroacetate and hydroxypyruvate on the entry of 14C from [1-14C]alanine into urea in rat hepatocytes.
Topics: Acetates; Alanine; Animals; Carbon Radioisotopes; Dichloroacetic Acid; Kinetics; Liver; Pyruvates; Rats; Urea | 1983 |
Short-term influences of dichloroacetate on genetically hyperlipemic rats.
Topics: Acetates; Animals; Dichloroacetic Acid; Disease Models, Animal; Fatty Acids, Nonesterified; Glucagon; Hyperlipidemias; Hypoglycemia; Insulin; Ketone Bodies; Obesity; Rats; Triglycerides | 1980 |
Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15").
Topics: Acetates; Animals; Aroclors; Calcium Gluconate; Carcinogens; Dichloroacetic Acid; Microsomes, Liver; Mutagens; N-substituted Glycines; Propylamines; Rats; Salmonella typhimurium; Vitamin B Complex | 1980 |
Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog.
Topics: Acetates; Alanine; Amino Acids; Animals; Dichloroacetic Acid; Dogs; Female; Glucagon; Gluconeogenesis; Glucose; Glycerol; Insulin; Kinetics; Liver; Male | 1980 |
Effects of oxalate and dichloroacetate on lipogenesis and ketogenesis in rat hepatocytes.
Topics: Acetates; Acetyl Coenzyme A; Animals; Dichloroacetic Acid; Female; Ketone Bodies; Lipid Metabolism; Liver; Oxalates; Oxalic Acid; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains | 1982 |
Inhibition of medium and short-chain fatty acid oxidation in rat heart mitochondria by dichloroacetate.
Topics: Acetates; Animals; Caprylates; Coenzyme A Ligases; Coumaric Acids; Dichloroacetic Acid; Fatty Acids; In Vitro Techniques; Kidney; Male; Mitochondria, Heart; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1982 |
Prolonged hypolactatemia and increased total pyruvate dehydrogenase activity by dichloroacetate.
Topics: Acetates; Animals; Blood Glucose; Dichloroacetic Acid; Glyoxylates; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxalates; Oxalic Acid; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate.
Topics: Acetates; Animals; Dichloroacetic Acid; Enzyme Activation; Female; Hydrocarbons, Chlorinated; Ketone Bodies; Liver; Male; Metabolism; Mice; Mice, Inbred ICR; Neural Conduction; Peripheral Nerves; Propionates; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Schwann Cells; Testis | 1982 |
Acute effects of dichloroacetate in the depancreatized dog: glucose synthesis and turnover.
Topics: Acetates; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Dogs; Female; Glucose; Kinetics; Pancreatectomy | 1982 |
Effect of sodium dichloroacetate on dental caries in diabetic rats.
Topics: Acetates; Animals; Dental Caries; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Ketone body and acetate formation from oleate by isolated rat testicular cells.
Topics: Acetates; Animals; Dichloroacetic Acid; Glucose; Hydrocarbons, Chlorinated; In Vitro Techniques; Ketone Bodies; Kinetics; Male; Oleic Acid; Oleic Acids; Propionates; Rats; Rats, Inbred Strains; Testis | 1982 |
Dichloroacetate tissue concentrations and its relationship to hypolactatemia and pyruvate dehydrogenase activation.
Topics: Acetates; Animals; Dichloroacetic Acid; Enzyme Activation; Lactates; Liver; Muscles; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains | 1982 |
Brief treatment with dichloroacetate does not modify suspected subacute necrotizing encephalomyelitis.
Topics: Acetates; Child, Preschool; Dichloroacetic Acid; Encephalomyelitis; Female; Humans | 1980 |
Dichloroacetate, sodium: 3-month oral toxicity studies in rats and dogs.
Topics: Acetates; Animals; Body Weight; Dichloroacetic Acid; Dogs; Eating; Female; Male; Rats; Sex Factors; Species Specificity | 1981 |
Consideration of the evidence for mechanisms of 1,1,2-trichloroethylene metabolism, including new identification of its dichloroacetic acid and trichloroacetic acid metabolites in mice.
Topics: Acetates; Animals; Biotransformation; Dichloroacetic Acid; Male; Mice; Trichloroacetic Acid; Trichloroethylene | 1980 |
Dichloroacetate: effects on exercise endurance in untrained rats.
Topics: 3-Hydroxybutyric Acid; Acetates; Adenosine Triphosphate; Animals; Dichloroacetic Acid; Glycogen; Hydroxybutyrates; Lactates; Lactic Acid; Male; Muscles; Phosphocreatine; Physical Exertion; Pyruvates; Pyruvic Acid; Rats; Time Factors | 1981 |
Long-term dichloroacetate administration to genetically hyperlipemic rats.
Topics: Acetates; Animals; Dichloroacetic Acid; Disease Models, Animal; Obesity; Rats | 1981 |
Effect of sodium dichloroacetate (DCA) on retinal lactate level in diabetic rat.
Topics: Acetates; Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Lactates; Male; Rats; Retina | 1981 |
Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver.
Topics: Acetates; Alanine; Animals; Dichloroacetic Acid; Dogs; Female; Gluconeogenesis; Kinetics; Lactates; Lactic Acid; Liver; Male | 1981 |
Cytochrome P-450-dependent metabolism of 1,1,2,2-tetrachloroethane to dichloroacetic acid in vitro.
Topics: Acetates; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Ethane; Hydrocarbons, Chlorinated; In Vitro Techniques; Microsomes, Liver; Rats | 1981 |
Studies on the regulation of leucine catabolism. III. Effects of dichloroacetate and 2-chloropropionate on leucine oxidation by the heart.
Topics: Acetates; Animals; Carbon Radioisotopes; Dichloroacetic Acid; Heart; Hydrocarbons, Chlorinated; Kinetics; Leucine; Male; Oxidation-Reduction; Perfusion; Propionates; Rats | 1980 |
Effect of dichloroacetate on plasma lactic acid in exercising dogs.
Topics: Acetates; Animals; Dichloroacetic Acid; Dogs; Dose-Response Relationship, Drug; Female; Lactates; Physical Exertion; Time Factors; Wakefulness | 1980 |
Biological disposition of sodium dichloroacetate in animals and humans after intravenous administration.
Topics: Acetates; Adult; Animals; Dichloroacetic Acid; Dogs; Humans; Injections, Intravenous; Kinetics; Liver Circulation; Male; Metabolic Clearance Rate; Middle Aged; Rats | 1980 |
Effect of dichloroacetate sodium on the lactacidemia of experimental endotoxin shock.
Topics: Acetates; Animals; Blood Gas Analysis; Blood Glucose; Corticosterone; Dichloroacetic Acid; Endotoxins; Hemodynamics; Hydrogen-Ion Concentration; Lactates; Male; Rabbits; Shock; Sodium Chloride; Time Factors | 1980 |
Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans.
Topics: Acetates; Adult; Alanine; Blood Glucose; Dichloroacetic Acid; Female; Humans; Kinetics; Lactates; Male; Metabolic Clearance Rate; Middle Aged | 1980 |
Renal and systemic acid-base effects of chronic dichloroacetate administration in dogs.
Topics: Acetates; Acid-Base Equilibrium; Animals; Calcium; Chlorides; Dichloroacetic Acid; Dogs; Electrolytes; Female; Kidney; Potassium; Sodium | 1980 |
Studies on the regulation of leucine catabolism. Mechanism responsible for oxidizable substrate inhibition and dichloroacetate stimulation of leucine oxidation by the heart.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acetates; Amino Acids, Branched-Chain; Animals; Dichloroacetic Acid; Enzyme Activation; In Vitro Techniques; Keto Acids; Ketone Oxidoreductases; Leucine; Male; Mitochondria, Heart; Multienzyme Complexes; Myocardium; Oxidation-Reduction; Rats | 1980 |
[Redox and phosphorylation equilibrium of the central metabolic pathway: rat liver profile in controls and after treatment with dichloroacetate and phenformin following dichloroacetate].
Topics: Acetates; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cytosol; Dichloroacetic Acid; Liver; Male; Mitochondria, Liver; NAD; NADP; Phenformin; Phosphates; Rats | 1980 |
In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation.
Topics: Acetates; Animals; Cells, Cultured; Clofibric Acid; Dichloroacetic Acid; Dose-Response Relationship, Drug; Glycolates; L-Lactate Dehydrogenase; Liver; Male; Mice; Microbodies; Oxidoreductases; Rats; Rats, Sprague-Dawley; Trichloroacetic Acid | 1993 |
Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetates; Acyl-CoA Oxidase; Animals; Cell Division; Chromatography, High Pressure Liquid; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Deoxyguanosine; Dichloroacetic Acid; DNA Damage; Drinking; Fresh Water; Hydroxylation; Lauric Acids; Liver; Male; Mice; Microbodies; Mixed Function Oxygenases; Oxidative Stress; Oxidoreductases; Reference Standards; Water Pollutants, Chemical | 1996 |
Metabolism of bromodichloroacetate in B6C3F1 mice.
Topics: Acetates; Animals; Biotransformation; Dichloroacetic Acid; Feces; Male; Mice; Mice, Inbred Strains; Tissue Distribution; Trichloroacetic Acid | 1995 |
Acid binding and detritylation during oligonucleotide synthesis.
Topics: Acetates; Acetonitriles; Base Sequence; Dichloroacetic Acid; Kinetics; Methylene Chloride; Molecular Sequence Data; Oligodeoxyribonucleotides; Spectrum Analysis; Trichloroacetic Acid; Trityl Compounds | 1996 |
Electrospray analysis of biological samples for trace amounts of trichloroacetic acid, dichloroacetic acid, and monochloroacetic acid.
Topics: Acetates; Administration, Inhalation; Dichloroacetic Acid; Humans; Mass Spectrometry; Reference Standards; Sensitivity and Specificity; Trichloroacetic Acid | 1997 |
Effect of pretreatment with dichloroacetate or trichloroacetate on the metabolism of bromodichloroacetate.
Topics: Acetates; Animals; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Cytosol; Dichloroacetic Acid; Drug Interactions; Liver; Male; Mice; Microsomes, Liver; Trichloroacetic Acid; Water Supply | 1997 |
Comparative genotoxicity of halogenated acetic acids found in drinking water.
Topics: Acetates; Animals; Chloroacetates; Dichloroacetic Acid; DNA Damage; Escherichia coli; Hydrocarbons, Brominated; Micronucleus Tests; Mutagenicity Tests; Mutagens; Salamandridae; Salmonella typhimurium; SOS Response, Genetics; Trichloroacetic Acid; Water Supply | 1997 |
Capillary zone electrophoresis with indirect UV detection of haloacetic acids in water.
Topics: Acetates; Cetrimonium; Cetrimonium Compounds; Chlorine; Dichloroacetic Acid; Disinfection; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Quaternary Ammonium Compounds; Surface-Active Agents; Trichloroacetic Acid; Trimethyl Ammonium Compounds; Water | 1998 |
Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes.
Topics: Acetates; Animals; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Female; Glyoxylates; Humans; Kinetics; Male; Mice; Microsomes, Liver; NADP; Oxalates; Oxalic Acid; Rats; Rats, Inbred F344; Sex Factors; Solvents; Species Specificity; Trichloroethylene | 1998 |
Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids.
Topics: Acetates; Animals; Biotransformation; Deuterium; Dichloroacetic Acid; Glutathione Transferase; Glyoxylates; Half-Life; Humans; Isoenzymes; Rats | 1999 |
Solid-phase microextraction coupled with gas chromatography-ion trap mass spectrometry for the analysis of haloacetic acids in water.
Topics: Acetates; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Trichloroacetic Acid; Water | 1999 |
Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry.
Topics: Acetals; Acetates; Acidosis, Lactic; Administration, Oral; Child; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Glucuronates; Glucuronides; Humans; Hydroxamic Acids; Reproducibility of Results; Sensitivity and Specificity; Trichloroacetic Acid | 1999 |
Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.
Topics: Acetates; Adolescent; Adult; Aged; Animals; Base Sequence; Chromatography, Affinity; Databases, Factual; Dichloroacetic Acid; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Ethacrynic Acid; Exons; Expressed Sequence Tags; Female; Fluoroacetates; Gene Frequency; Glutathione Transferase; Haplotypes; Humans; Hydrocarbons, Chlorinated; Isoenzymes; Male; Middle Aged; Molecular Sequence Data; Phenylacetates; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Propionates; Rats; Recombinant Fusion Proteins; Sequence Alignment | 2000 |
The disinfection by-products dichloro-, dibromo-, and bromochloroacetic acid impact intestinal microflora and metabolism in Fischer 344 rats upon exposure in drinking water.
Topics: Acetates; Animals; Bacteria; Body Weight; Dichloroacetic Acid; Intestines; Male; Organ Size; Rats; Rats, Inbred F344; Water Pollutants, Chemical; Water Supply | 2000 |
The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters.
Topics: Acetates; Biodegradation, Environmental; Dichloroacetic Acid; Fresh Water; Trichloroacetic Acid; Trifluoroacetic Acid; Water Pollutants | 2001 |
Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.
Topics: Acetates; Dichloroacetic Acid; Fluoroacetates; Glutathione Transferase; Halogens; Hydrocarbons, Chlorinated; Propionates; Structure-Activity Relationship; Substrate Specificity | 2001 |
Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.
Topics: Acetates; Acetone; Animals; Dichloroacetic Acid; Environmental Pollutants; Glutathione Transferase; Immunoblotting; Immunohistochemistry; Male; Maleates; Organ Specificity; Rats; Rats, Inbred F344; Subcellular Fractions | 2002 |
Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).
Topics: Acetates; Acetone; Biotransformation; cis-trans-Isomerases; Dichloroacetic Acid; Enzyme Inhibitors; Glutathione Transferase; Humans; Hydrogen-Ion Concentration; Kinetics; Maleates; Polymorphism, Single Nucleotide; Recombinant Proteins; Substrate Specificity | 2002 |
Nephrotoxicity of chlorofluoroacetic acid in rats.
Topics: Acetates; Animals; Dichloroacetic Acid; Dose-Response Relationship, Drug; Fluorides; Fluoroacetates; Glutathione Transferase; Injections, Intraperitoneal; Kidney; Liver; Male; Microscopy, Electron; Rats; Rats, Inbred F344; Time Factors; Urinalysis | 2002 |
Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin.
Topics: Acetates; Acetic Acid; Cation Exchange Resins; Chromatography, Ion Exchange; Dichloroacetic Acid; Electric Conductivity; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity; Solvents; Sulfuric Acids; Trichloroacetic Acid; Water | 2003 |
[Treatment of the neuropsychic manifestations of chronic alcoholism with the diisopropylamine salt of dichloroacetic acid].
Topics: Acetates; Alcoholism; Ammonium Compounds; Dichloroacetic Acid; Humans; Mental Disorders; Propylamines; Psychoses, Alcoholic; Quaternary Ammonium Compounds | 1962 |
[OBTAINING THE METHYL ESTER AND OTHER DERIVATIVES OF DICHLOROACETIC ACID FROM DICHLOROACETYL CHLORIDE].
Topics: Acetates; Amides; Anesthetics, Local; Chemistry, Pharmaceutical; Chlorides; Dichloroacetic Acid; Esters; Pharmacy | 1963 |
Pyruvate and acetate metabolism in termite mitochondria.
Topics: Acetates; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Isoptera; Mitochondria; Oxygen Consumption; Pyruvate Dehydrogenase Complex; Pyruvates; Sodium Fluoride | 2003 |
Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat.
Topics: Acetates; Animals; Area Under Curve; Dichloroacetic Acid; Disinfection; Drug Interactions; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Trichloroacetic Acid; Trihalomethanes; Water Purification | 2003 |
Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetates; Animals; Culture Techniques; Dichloroacetic Acid; Disinfectants; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Embryo, Mammalian; Female; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens; Water Pollutants, Chemical | 2004 |
Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.
Topics: Acetates; Adsorption; Dichloroacetic Acid; Ethyl Chloride; Half-Life; Hydrogen-Ion Concentration; Iron; Models, Theoretical; Oxidation-Reduction; Polymerase Chain Reaction; Soil Microbiology; Time Factors; Trichloroethanes; Water Pollutants, Chemical; Water Purification | 2004 |
DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney.
Topics: Acetates; Animals; Dichloroacetic Acid; Disinfectants; DNA Methylation; Female; Genes, myc; Kidney; Male; Methionine; Mice; Rats; Risk Assessment; Trichloroacetic Acid; Water Supply | 2005 |
Comparison of haloacetic acids in the environment of the Northern and Southern Hemispheres.
Topics: Acetates; Canada; Chemical Precipitation; Chile; Dichloroacetic Acid; Environment; Industry; Malawi; Pinus; Plant Leaves; Soil; Soil Pollutants; Trichloroacetic Acid; United Kingdom | 2005 |
Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro.
Topics: Abnormalities, Drug-Induced; Acetates; Animals; Dichloroacetic Acid; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Mice; Time Factors; Water Pollutants, Chemical | 2006 |
Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.
Topics: Acetates; Acetic Anhydrides; Animals; Antibodies, Antinuclear; Antibodies, Blocking; Autoimmunity; CD28 Antigens; CD3 Complex; Cells, Cultured; Cytokines; Dichloroacetic Acid; Female; Homozygote; Immunoglobulins; Lymphocytes; Mice; Mice, Inbred MRL lpr; Pulmonary Alveoli; Spleen | 2006 |
[Determination of trace haloacetic acids in drinking water using ion chromatography coupled with solid phase extraction].
Topics: Acetates; Chromatography, Ion Exchange; Dichloroacetic Acid; Hydroxides; Sodium Hydroxide; Solid Phase Extraction; Water; Water Supply | 2006 |
Fate of THMs and HAAs in low TOC surface water.
Topics: Acetates; Adsorption; Carbon; Chlorine; Dichloroacetic Acid; Disinfection; Filtration; Halogens; Korea; Seasons; Trichloroacetic Acid; Trihalomethanes; Water Pollutants, Chemical; Water Purification | 2009 |
Determination of ten haloacetic acids in drinking water using high-performance and ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Acetates; Chromatography, High Pressure Liquid; Dichloroacetic Acid; Halogens; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Trichloroacetic Acid; Water | 2009 |
Effects of crystalline structures and surface functional groups on the adsorption of haloacetic acids by inorganic materials.
Topics: Acetates; Adsorption; Aluminum Oxide; Crystallization; Dichloroacetic Acid; Electrolytes; Halogens; Inorganic Chemicals; Onium Compounds; Porosity; Silicates; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification; Zeolites | 2009 |
Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes.
Topics: Acetates; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Dichloroacetic Acid; Glutathione; Glycolysis; Rats; Rats, Wistar; Trichloroacetic Acid | 2011 |
Developing new anti-cancer drugs.
Topics: Acetates; Antineoplastic Agents; Dichloroacetic Acid; Drug Design; Drug Discovery; Drugs, Investigational; Humans; Melanoma; Models, Biological; Neoplasms; Skin Neoplasms | 2011 |
Haloacetic acids in swimming pools: swimmer and worker exposure.
Topics: Acetates; Adult; Child; Dichloroacetic Acid; Female; Humans; Male; Occupational Exposure; Swimming; Swimming Pools; Trichloroacetic Acid; Water | 2011 |
Comparative electrochemical treatments of two chlorinated aliphatic hydrocarbons. Time course of the main reaction by-products.
Topics: Acetates; Chemistry Techniques, Analytical; Chlorine; Dichloroacetic Acid; Diffusion; Electrochemistry; Electrodes; Equipment Design; Ethane; Ethylene Dichlorides; Hydrocarbons, Chlorinated; Hydrogen Peroxide; Oxygen; Time Factors | 2011 |
[Chlorination byproducts formation potentials of typical nitrogenous organic compounds in water].
Topics: Acetates; Chlorine; Chloroform; Dichloroacetic Acid; Disinfectants; Disinfection; Halogenation; Nitrogen Compounds; Water Pollutants, Chemical; Water Purification | 2011 |
Characterisation of an L-haloacid dehalogenase from the marine psychrophile Psychromonas ingrahamii with potential industrial application.
Topics: Acetates; Amino Acid Sequence; Base Sequence; Biocatalysis; Cloning, Molecular; Computational Biology; Dichloroacetic Acid; DNA Primers; Escherichia coli; Gammaproteobacteria; Hydrolases; Industrial Microbiology; Models, Molecular; Molecular Sequence Data; Propionates; Protein Conformation; Sequence Analysis, DNA; Temperature | 2013 |
A convenient and sensitive method for haloacetic acid analysis in tap water by on-line field-amplified sample-stacking CE-ESI-MS.
Topics: Acetates; Dichloroacetic Acid; Electrophoresis, Capillary; Spectrometry, Mass, Electrospray Ionization; Trichloroacetic Acid; Water Supply | 2013 |
DBP formation in hot and cold water across a simulated distribution system: effect of incubation time, heating time, pH, chlorine dose, and incubation temperature.
Topics: Acetates; Acetonitriles; Chlorine; Dichloroacetic Acid; Disinfection; Drinking Water; Halogenation; Hydrogen-Ion Concentration; Propane; Temperature; Time Factors; Trichloroacetic Acid; Water; Water Supply | 2013 |
Effect of dissolved oxygen concentration on iron efficiency: Removal of three chloroacetic acids.
Topics: Acetates; Dichloroacetic Acid; Iron; Oxygen; Trichloroacetic Acid; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification | 2015 |
Simultaneous determination of three chloroacetic acids, three herbicides, and 12 anions in water by ion chromatography.
Topics: Acetates; Anions; Benzothiadiazines; Chlorine; Chloroacetates; Chromatography, Ion Exchange; Dichloroacetic Acid; Glycine; Glyphosate; Herbicides; Ions; Limit of Detection; Picloram; Reproducibility of Results; Trichloroacetic Acid; Water | 2015 |
In vitro bioacessibility and transport across Caco-2 monolayers of haloacetic acids in drinking water.
Topics: Acetates; Caco-2 Cells; Cell Membrane Permeability; Dichloroacetic Acid; Disinfection; Drinking Water; Humans; Tandem Mass Spectrometry; Trichloroacetic Acid; Water Pollutants, Chemical; Water Purification; Water Supply | 2016 |
Associations Between Disinfection By-Product Exposures and Craniofacial Birth Defects.
Topics: Abnormalities, Multiple; Acetates; Adult; Case-Control Studies; Chloroform; Cleft Lip; Cleft Palate; Craniofacial Abnormalities; Dichloroacetic Acid; Dietary Exposure; Disinfectants; Drinking Water; Ear; Eye Abnormalities; Female; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Trichloroacetic Acid; Trihalomethanes; Water Purification; Young Adult | 2018 |
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.
Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroacetic Acid; Evidence-Based Medicine; Glioblastoma; Heart; Humans; Ketones; Lactic Acid; Models, Theoretical; Neoplasms; Oxygen; Perfusion; Rats | 2019 |
Degradation of haloacetic acids with the Fenton-like and analysis by GC-MS: use of bioassays for monitoring of genotoxic, mutagenic and cytotoxic effects.
Topics: Acetates; Acetic Acid; Biological Assay; Chloroacetates; Dichloroacetic Acid; DNA Damage; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Brominated; Mutagens; Toxicity Tests; Trichloroacetic Acid; Water; Water Supply | 2019 |
Formation of haloacetic acids from different organic precursors in swimming pool water during chlorination.
Topics: Acetates; Benzophenones; Dichloroacetic Acid; Disinfectants; Disinfection; Halogenation; Humic Substances; Swimming Pools; Water Pollutants, Chemical; Water Purification | 2020 |
Rapid removal of trace haloacetic acids from drinking water by a continuous adsorption process using graphene oxide.
Topics: Acetates; Adsorption; Dichloroacetic Acid; Drinking Water; Graphite; Water Pollutants, Chemical | 2022 |
Concentration-dependent effects of dichloroacetate in type 2 diabetic hearts assessed by hyperpolarized [1-
Topics: Acetates; Animals; Bicarbonates; Diabetes Mellitus, Type 2; Dichloroacetic Acid; Heart; Magnetic Resonance Imaging; Pyruvic Acid; Rats | 2022 |
The Comparative Experimental Study of Sodium and Magnesium Dichloroacetate Effects on Pediatric PBT24 and SF8628 Cell Glioblastoma Tumors Using a Chicken Embryo Chorioallantoic Membrane Model and on Cells In Vitro.
Topics: Acetates; Animals; Chick Embryo; Chickens; Chorioallantoic Membrane; Dichloroacetic Acid; Glioblastoma; Humans; Magnesium; Monocarboxylic Acid Transporters; Proliferating Cell Nuclear Antigen; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sodium; Solute Carrier Family 12, Member 2; Survivin; Tumor Suppressor Protein p53 | 2022 |