phenyl acetate has been researched along with azd1981 in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (90.91) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Bonnert, R; Brough, S; Cook, AR; Dickinson, MR; Dougall, I; Logan, C; Luker, T; Mohammed, RT; Paine, S; Sanganee, HJ; Sargent, C; Schmidt, JA; Teague, S; Thom, S | 1 |
| Akam, E; Bell, FM; Bonnert, RV; Dainty, IA; Dougall, IG; Heinemann, A; Marshall, C; Sargent, CA; Schmidt, JA | 1 |
| Foster, M; Snell, N; Vestbo, J | 1 |
| Bauer, C; Bradley, ME; Charlton, SJ; Dubois, G; Miah, A; Reilly, J; Riddy, DM; Sandham, DA; Sykes, DA; Watson, SJ; Willard, E | 1 |
| Brännström, M; Brealey, C; Gillen, M; Grime, K; Jones, B; Kühn, W; Mant, T; Nordell, P; Pehrson, R; Svanberg, P | 1 |
| Bjermer, L; Kuna, P; Tornling, G | 1 |
| Aoki, Y; Hamrén, B; Hooker, AC; Röshammar, D | 1 |
| Bateman, ED; Ivanov, S; Luke, S; O'Brien, C; Rugman, P; Uddin, M | 1 |
| Aivazidis, A; Andersson, EM; Broberg, M; Ericsson, H; Hompesch, M; Kjaer, M; Löfgren, L; Morrow, L; Parkinson, J; Ryberg, E; Rydén-Bergsten, T; Schnecke, V; Skrtic, S; Sörhede Winzell, M; Tyrberg, B; Watkins, E; Wennberg Huldt, C | 1 |
| Chichester, K; Devine, K; Oliver, ET; Saini, SS; Sterba, PM; Vonakis, BM; Wegner, C | 1 |
| Conley, D; Cousens, L; Erickson, KA; Grammer, LC; Guo, A; Kato, A; Kern, RC; Peters, AT; Price, CPE; Schleimer, RP; Smith, SS; Stevens, WW; Suh, LA; Tan, BK; Vu, TT; Welch, KC | 1 |
7 trial(s) available for phenyl acetate and azd1981
| Article | Year |
|---|---|
Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Indoles; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Receptors, Immunologic; Receptors, Prostaglandin; Severity of Illness Index; Treatment Outcome; Vital Capacity | 2013 |
An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator.
Topics: Acetates; Adult; Area Under Curve; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Hepatocytes; Humans; Indoles; Male; Pilot Projects; Time Factors; Warfarin | 2017 |
Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma.
Topics: Acetates; Administration, Oral; Adolescent; Adult; Asthma; Double-Blind Method; Female; Humans; Indoles; Male; Middle Aged; Receptors, Immunologic; Receptors, Prostaglandin; Young Adult | 2016 |
Efficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting β
Topics: Acetates; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Anti-Asthmatic Agents; Asthma; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indoles; Male; Middle Aged; Receptors, Immunologic; Receptors, Prostaglandin | 2018 |
Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.
Topics: Acetates; Blood Glucose; C-Peptide; Cell Line; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Indoles; Insulin; Islets of Langerhans; Male; Middle Aged; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Transcription Factors | 2018 |
Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria.
Topics: Acetates; Administration, Oral; Adult; Aged; Chronic Disease; Eosinophils; Female; Humans; Indoles; Male; Middle Aged; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Urticaria | 2019 |
Efficacy of an oral CRTH2 antagonist (AZD1981) in the treatment of chronic rhinosinusitis with nasal polyps in adults: A randomized controlled clinical trial.
Topics: Acetates; Adrenal Cortex Hormones; Adult; Chronic Disease; Humans; Immunity, Innate; Indoles; Lymphocytes; Nasal Polyps; Quality of Life; Rhinitis; Sinusitis | 2022 |
4 other study(ies) available for phenyl acetate and azd1981
| Article | Year |
|---|---|
Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.
Topics: Acetates; Drug Discovery; Humans; Indoleacetic Acids; Indoles; Neutrophils; Receptors, Immunologic; Receptors, Prostaglandin | 2011 |
Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.
Topics: Acetates; Administration, Oral; Animals; Anti-Asthmatic Agents; Basophils; Bone Marrow Cells; CD11b Antigen; Cell Shape; Chemotaxis, Leukocyte; Dogs; Eosinophils; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Mice; Prostaglandin D2; Rabbits; Rats; Receptors, Prostaglandin; Species Specificity; Th2 Cells; Up-Regulation | 2013 |
Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.
Topics: Acetates; Animals; Anti-Allergic Agents; Binding, Competitive; Cell Shape; Cells, Cultured; CHO Cells; Cricetulus; Drugs, Investigational; Eosinophils; Humans; Indoleacetic Acids; Indoles; Kinetics; Ligands; Prostaglandin D2; Pyridines; Receptors, Immunologic; Receptors, Prostaglandin; Recombinant Proteins; Solubility; Th2 Cells; Tritium | 2016 |
Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection.
Topics: Acetates; Anti-Asthmatic Agents; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Humans; Indoles; Male; Nonlinear Dynamics | 2017 |