phentermine has been researched along with fenfluramine in 248 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (12.90) | 18.7374 |
| 1990's | 144 (58.06) | 18.2507 |
| 2000's | 64 (25.81) | 29.6817 |
| 2010's | 7 (2.82) | 24.3611 |
| 2020's | 1 (0.40) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Brady, JV; Griffiths, RR; Snell, JD | 2 |
| Munro, JF | 1 |
| Grünberger, J; Karobath, M; Linzmayer, L; Saletu, B | 1 |
| Bleehen, SS; Clark, RG; Edwards, IR | 1 |
| Weintraub, M | 2 |
| Balder, A; Cox, C; Lasagna, L; Madan, M; Schuster, B; Sundaresan, PR; Weintraub, M | 1 |
| Balder, A; Byrne, L; Ginsberg, G; Madan, M; Schuster, B; Stein, EC; Sundaresan, PR; Weintraub, M | 1 |
| Moscucci, M; Schuster, B; Stein, EC; Sundaresan, PR; Weintraub, M | 1 |
| Averbuch, M; Byrne, L; Cox, C; Schuster, B; Stein, EC; Sundaresan, PR; Weintraub, M | 1 |
| Averbuch, M; Byrne, L; Schuster, B; Stein, EC; Sundaresan, PR; Weintraub, M | 1 |
| Cox, C; Sundaresan, PR; Weintraub, M | 1 |
| Schuster, B; Sundaresan, PR; Weintraub, M | 1 |
| Young, R | 1 |
| Silverstone, T | 1 |
| Kutscher, CL | 1 |
| Opitz, K | 1 |
| Beckett, AH; Brookes, LG | 1 |
| Hoyer, I; Van Zwieten, PA | 1 |
| Dolfini, E; Jori, A | 1 |
| Court, JM | 1 |
| Anderson, J | 1 |
| Pawan, GS | 1 |
| Pardo, EG; Vidrio, H | 1 |
| Johnson, SA; Maickel, RP | 1 |
| Sachweh, H | 1 |
| Briggs, M; Steel, JM | 1 |
| Mace, PM; Malcolm, AD; Outar, KP; Pawan, GL | 2 |
| Offermeier, J; Potgieter, B | 1 |
| Cox, RH; Maickel, RP | 1 |
| Kemper, F | 1 |
| Opitz, K; Weischer, ML | 2 |
| Weischer, ML | 1 |
| Banerjee, SP; Hasday, JD; Hershey, LA; Kroening, BH; Sundaresan, PR; Weintraub, M | 1 |
| Hasday, JD; Lockwood, DH; Mushlin, AI; Weintraub, M | 1 |
| Farquhar, DL; Galloway, SM; Munro, JF | 1 |
| Kärkkäinen, S; Kuitunen, T; Ylitalo, P | 1 |
| Arch, JR | 1 |
| Khan, M; Lum, CT; Rao, V | 1 |
| Atkinson, RL; Hubbard, VS | 1 |
| Hitzig, P | 1 |
| Sellers, EM | 1 |
| Rothman, RB | 2 |
| Boisaubin, EV | 1 |
| Atkinson, RL; Blank, RC; Loper, JF; Lutes, RA; Schumacher, D | 1 |
| Baumann, MH; Rothman, RB; Schuster, CR | 1 |
| Clemenson, ND | 1 |
| McBurney, D; Schechter, MD | 1 |
| Brauer, LH; de Wit, H; Johanson, CE; Rothman, RB; Schuster, CR | 1 |
| Budenholzer, B | 1 |
| Boynton, KK; Schembre, DB | 1 |
| Cerda, JJ | 1 |
| Kushner, R | 1 |
| Lew, R; Seiden, LS; Vosmer, G; Weisenberg, B | 1 |
| Guy-Grand, B | 1 |
| Klein, HM; Raison, CL | 1 |
| Shuster, J | 1 |
| Glowa, JR; Matecka, D; Rice, KC; Rothman, RB | 1 |
| Berkowitz, RI; Foster, GD; Steen, SN; Stunkard, AJ; Vogt, RA; Wadden, TA | 1 |
| Baumann, MH; Goldberg, SR; Rothman, RB; Schindler, CW; Shoaib, M | 1 |
| Jeffers, LA | 2 |
| Newman, R | 1 |
| Nightingale, SL | 1 |
| Feske, SK; Stieg, PE; Teoh, SK; Wen, PY | 1 |
| Connolly, HM; Crary, JL; Edwards, BS; Edwards, WD; Hensrud, DD; McGoon, MD; Schaff, HV | 1 |
| Chang, HT; Evans, RJ; Kessler, SC; Mark, EJ; Patalas, ED | 1 |
| Curfman, GD | 1 |
| Healy, BP | 1 |
| Cupp, MJ; Garrett, SD | 1 |
| Graham, DJ; Green, L | 1 |
| DeMeo, MT; Kazi, N; Mikolaitis, S; Mobarhan, S | 1 |
| Boughner, DR | 1 |
| Hancock, EW | 1 |
| SoRelle, R | 1 |
| Torretta, LK | 1 |
| Blackburn, GL; Chan, S; Miller, D | 1 |
| Angell, M; Kassirer, JP | 1 |
| Josefson, D | 1 |
| Thompson, PD | 1 |
| Kurz, X; Van Ermen, A | 1 |
| Corya, BC; Glassman, RD; Rasmussen, S | 1 |
| Bantle, JP; Raatz, S; Redmon, B | 1 |
| Wolff, FW | 1 |
| Spitzer, WO | 1 |
| Carruba, MO; Nisoli, E | 1 |
| Anchors, M; Griffen, L | 2 |
| Hirsch, J | 1 |
| Scheen, AJ | 1 |
| Atkinson, RL; Blank, RC; Dhurandhar, NV; Ritch, DL; Schumacher, D | 1 |
| Cheng, TO | 3 |
| Aronne, LJ | 1 |
| Giese, SY | 1 |
| Njo, L; Rich, JM; Roberts, KW; Smith, KP | 1 |
| Aurigemma, GP; Gaasch, WH | 1 |
| Bagri, S; Reddy, G | 1 |
| Baumann, MH; Rothman, RB | 1 |
| Connolly, J; Kelso, E; Shiesha, S; Trilling, J; Verni, C | 1 |
| Brown-Beasley, MW | 1 |
| Capriotti, T | 1 |
| Sandrick, KM | 1 |
| Fisher, H; Halladay, AK; Wagner, GC | 2 |
| Cloward, TV; Fowles, RE; Yowell, RL | 1 |
| Davis, S; Hilsen, K; Iyer, P | 1 |
| Roth, JD; Rowland, NE | 2 |
| Friedlander, MP | 1 |
| Baumann, MH; Elmer, GI; Rea, W; Rothman, RB; Shippenberg, TS | 1 |
| Aber, JL; Berkowitz, RI; Foster, GD; Silvestry, F; St John Sutton, MG; Stunkard, AJ; Vogt, RA; Wadden, TA | 1 |
| Ciraulo, DA; Duan, SX; Granda, BW; Grassi, JM; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL | 1 |
| Rea, WP; Rothman, RB; Shippenberg, TS | 1 |
| Gregory, RJ; Zimmer, JE | 1 |
| Borrell, L; Foreyt, JP; Haddock, CK; Poston, WS | 1 |
| Shiffman, MA | 1 |
| Asinger, RW; Dick, CD; Hartley, GG; Herzog, CA; Khan, MA; Madlon-Kay, R; St Peter, JV; Vessey, JT | 1 |
| Derby, LE; Jick, H; Jick, SS; Meier, CR; Vasilakis, C; Weinrauch, LA | 1 |
| Devereux, RB | 1 |
| Cannistra, AJ; Cannistra, LB | 1 |
| McCann, UD; Ricaurte, GA; Yuan, J | 1 |
| Balcioglu, A; Wurtman, RJ | 1 |
| Cherin, P; Godeau, P; Tellier, P | 1 |
| Eligulashvili, V; McCann, UD; Ricaurte, GA | 1 |
| Biron, CR | 1 |
| Shapiro, S | 1 |
| Crisanti, CA | 1 |
| Maher, TJ; Ulus, IH; Wurtman, RJ | 1 |
| Baumann, MH; Goldberg, SR; Munzar, P; Shoaib, M | 1 |
| Cowley, G; Springen, K | 1 |
| Katz, DA; Maloney, MJ; McConville, BJ; Sutkamp, JC | 1 |
| Duran, CM; Garon, CF; Oury, JH | 1 |
| Borsari, BE; Landa, DW; Tovar, EA | 1 |
| Derby, LE; Jick, H; Myers, MW | 1 |
| Aber, JL; Berkowitz, RI; Foster, GD; Silvestry, FE; Sutton, MG; Wadden, TA | 1 |
| Silvestry, FE; St John Sutton, M | 1 |
| Bantle, JP; Kwong, CA; Raatz, SK; Redmon, JB; Swanson, JE; Thomas, W | 1 |
| Fedullo, P; Masliah, E; Strother, J; Yi, ES | 1 |
| Fisher, H; Halladay, AK; Hsu, T; Sekowski, A; Wagner, GC | 1 |
| Biswas, SS; Donovan, CL; Forbess, JM; Landolfo, KP; Royal, SH | 1 |
| Bray, GA; Glancy, DL; Greenway, F; Helmcke, F; Ryan, DH; Sander, G; Subramaniam, P; Volaufova, J | 1 |
| Pi-Sunyer, FX | 1 |
| Maher, TJ; Wellman, PJ | 1 |
| Blake, J; Koury, R; Stapczynski, JS; Stone, CK | 1 |
| Bowman, BA; Graham, DJ; Green, L; Li, R; Serdula, MK; Williamson, DF | 1 |
| Beare, J; Crary, JL; Jones, J; Keane, MG; Kimmel, SE; Kinman, JL; Sammel, M; Strom, BL; Sutton, MS | 1 |
| Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M | 1 |
| Asinas, LA; Blackburn, GL; Burger, AJ; Charlamb, MJ; Flickner, SR; Kim, J; Sherman, HB | 1 |
| Schiller, NB | 1 |
| Pallasch, TJ | 1 |
| Adams, C; Cohen, A | 1 |
| Bray, GA; Greenway, FL; Rood, JC; Ryan, DH; Smith, SR; Tucker, EW | 1 |
| McFadden, PM; Mehra, M; Park, M; Prasad, A; Scott, R; Uber, PA | 1 |
| Bailey, KR; Connolly, HM; Grogan, M; Hensrud, DD; Jensen, MD; Miller, FA | 1 |
| Asinger, RW | 1 |
| Tellier, P | 1 |
| Pollick, C | 1 |
| Connolly, HM; McGoon, MD | 1 |
| Bonow, RO; Kancherla, MK; Mehlman, DJ; Mulderink, TA; Parker, M; Salti, HI | 1 |
| Atkinson, RL; Blank, RC; Dhurandhar, NV; Schumacher, D | 1 |
| Sniderman, AD | 1 |
| Hoebel, BG; Rada, PV | 1 |
| Abenhaim, L; Rich, S; Rubin, L; Schneeweiss, S; Walker, AM | 1 |
| Curzon, G; Gibson, EL | 1 |
| Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D | 1 |
| Jick, H | 1 |
| Bantle, JP; Kwong, CA; Raatz, SK; Redmon, JB; Rothman, RB; Swanson, JE | 1 |
| Ayestas, MA; Baumann, MH; Brockington, A; Dersch, CM; Rice, KC; Rothman, RB | 1 |
| Brand, NJ; Roy, A; Yacoub, MH | 1 |
| Constantine, GD; Davis, KD; Jollis, JG; Kisslo, J; Landolfo, CK; Ryan, T | 1 |
| Connolly, HM; Grogan, M; Miller, FA; Teramae, CY | 1 |
| Gross, SB | 1 |
| Widgren, S | 1 |
| Allen, S; Henderson, J | 1 |
| Buchbinder, NA; Daley, WL; Gross, SB; Hickey, A; Lepor, NE; Luko, SP; Naqvi, TZ; Rizzo, MJ; Samuels, BA | 1 |
| Acosta, T; Ehrman, R; Gariti, P; Kampman, KM; Muller, E; O'Brien, CP; Pettinati, H; Rukstalis, M | 1 |
| Goldstein, SE; Levy, Y; Shoenfeld, Y | 1 |
| Farfel, Z; Mouallem, M; Wolf, I | 1 |
| Alexander, RE | 1 |
| Dasgupta, A; Kim, NH; Palmer, RB | 1 |
| Birkeland, KI; Tonstad, S | 1 |
| Beatty, JA; Capshaw, LC; Colbert, KM; Miller, SE; Rockas, CG; Yen, J | 1 |
| St John Sutton, M | 1 |
| Weissman, NJ | 1 |
| Carpenter, W; Rudin, R | 1 |
| Golden, F | 1 |
| Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S | 1 |
| Crosby, RD; Hartley, GG; Kolotkin, RL; Nicol, S; Williams, GR | 1 |
| Kaddoumi, A; Kubota, A; Nakashima, K; Nakashima, MN; Takahashi, M | 1 |
| Caccitolo, JA; Connolly, HM; Orszulak, TA; Rubenson, DS; Schaff, HV | 1 |
| Heal, DJ; Kilpatrick, IC; Traut, M | 1 |
| Howlin, D | 1 |
| Kaddoumi, A; Nakashima, K; Nakashima, MN | 1 |
| Hutchins, GM; Volmar, KE | 1 |
| Tomita, T; Zhao, Q | 1 |
| Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL; Kao, KK | 1 |
| Allen, MR; Dahl, CF | 1 |
| Jacobs, M; Liang, D; Popp, RL; Vagelos, R | 1 |
| Aspley, S; Auerbach, S; Brammer, R; Fray, A; Heal, D; Tao, R | 1 |
| Arnett, DK; Bella, JN; de Simone, G; Devereux, RB; Hopkins, PN; Kitzman, DW; Liu, JE; Morgan, D; Oberman, A; Palmieri, V; Roman, MJ | 1 |
| Vaughan, SF | 1 |
| Derry, S; Loke, YK; Pritchard-Copley, A | 1 |
| Rigolin, VH; Seghatol, FF | 1 |
| Decker, P; Gelgand, EA; Prasad, A; Roldan, CA; Shively, BK | 1 |
| Gross, SB; Lepor, NE | 1 |
| Jollis, JG; Miller, WC; Ryan, T; Sachdev, M | 1 |
| Brennan, TA; Mello, MM; Studdert, DM | 1 |
| Gross, SB; Naqvi, TZ | 1 |
| Jones, SL; Miller, DK; Wellman, PJ | 1 |
| Kaddoumi, A; Maki, T; Matsumura, Y; Nakamura, J; Nakashima, K; Nakashima, MN | 1 |
| Dunlop, PC; Johnson, GJ; Leis, LA; Weir, EK | 1 |
| Rice, B | 1 |
| Hess, MA | 1 |
| Bigler, E; Canick, J; Levin, RB; Lupien, SJ; Wolkowitz, OM | 1 |
| Horton, MR; Tuder, RM | 1 |
| Cheng, D; Chi, CL; Gan, J; Han, S; Largent, BL; O'Tanyi, EJ; Rohrbach, KW; Taub, R; Zhang, H | 1 |
| O'Connor, KA; Roth, BL | 1 |
| Roth, BL; Setola, V | 1 |
| Atkinson, RL; Dhurandhar, NV; Rahko, PS; Whigham, LD | 1 |
| Donnelly, KB | 1 |
| Baumann, MH; Blough, BE; Rothman, RB | 1 |
| Kaplan, LM | 1 |
| Chaliki, HP; Najib, MQ; Surapaneni, P; Vinales, KL | 1 |
| Behan, DP; Grottick, AJ; Morgan, M; Sage, C; Sanabria, EK; Whelan, K | 1 |
| Ceulemans, B; Gammaitoni, A; Keane, MG; Lagae, L; Marchau, F; Paelinck, BP; Pringsheim, M; Schoonjans, AS | 1 |
| Rajamannan, NM | 1 |
| Kohli, P; Koshkelashvili, N; Linefsky, J | 1 |
| Ambati, A; Assaly, R; Burmeister, C; Daboul, J; Iftikhar, S; Moukarbel, G; Patel, M | 1 |
38 review(s) available for phentermine and fenfluramine
| Article | Year |
|---|---|
Clinical aspects of the treatment of obesity by drugs: a review.
Topics: Amphetamines; Appetite Depressants; Clinical Trials as Topic; Diethylpropion; Drug Tolerance; Female; Fenfluramine; Humans; Mazindol; Middle Aged; Obesity; Phenmetrazine; Phentermine | 1979 |
Treatment of obesity. Appetite suppressant drugs and intestinal by-pass surgery.
Topics: Amphetamines; Appetite Depressants; Diethylpropion; Fenfluramine; Humans; Intestine, Small; Mazindol; Methylcellulose; Obesity; Phenmetrazine; Phentermine | 1976 |
Clinical use of appetite suppressants.
Topics: Amphetamines; Appetite Depressants; Body Weight; Diethylpropion; Double-Blind Method; Drug Tolerance; Eating; Fenfluramine; Humans; Hunger; Mazindol; Obesity; Phenmetrazine; Phentermine; Phenylpropanolamine | 1986 |
The management of obesity.
Topics: Adolescent; Adult; Amphetamine; Body Weight; Child; Chlorphentermine; Diet, Reducing; Diethylpropion; Fenfluramine; Humans; Monoamine Oxidase Inhibitors; Obesity; Phentermine; Starvation | 1972 |
Drugs and appetite.
Topics: Appetite; Appetite Depressants; Biguanides; Cyproheptadine; Diethylpropion; Fenfluramine; Humans; Methylcellulose; Phentermine; Stimulation, Chemical; Thyroxine; Triiodothyronine | 1974 |
[Anorexics. 25].
Topics: Amphetamine; Appetite Depressants; Chemical Phenomena; Chemistry; Chlorphentermine; Ephedrine; Fenfluramine; Humans; Morpholines; Phentermine | 1968 |
The current status of antiobesity drugs.
Topics: Adult; Amphetamine; Appetite Depressants; Body Weight; Child; Diethylpropion; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Mazindol; Obesity; Phentermine | 1984 |
Combined drug treatment of obesity.
Topics: Adrenergic Agents; Appetite Depressants; Benzocaine; Drug Therapy, Combination; Ephedrine; Fenfluramine; Humans; Obesity; Phentermine; Phenylpropanolamine; Serotonin Agents | 1995 |
The treatment of obesity. A call for prudence and professionalism.
Topics: Advertising; Appetite Depressants; Drug Prescriptions; Fenfluramine; Humans; Obesity; Phentermine; United States | 1997 |
Pharmacological approaches to intervention.
Topics: Anti-Obesity Agents; Appetite Depressants; Fenfluramine; Humans; Obesity; Phentermine; Time Factors; Weight Loss | 1997 |
Anesthetic considerations for the new antiobesity medications.
Topics: Anesthesia, General; Appetite Depressants; Drug Interactions; Drug Therapy, Combination; Fenfluramine; Humans; Phentermine | 1996 |
The fenfluramine/phentermine combination for weight loss.
Topics: Appetite Depressants; Clinical Trials as Topic; Drug Therapy, Combination; Fenfluramine; Humans; Phentermine; Weight Loss | 1997 |
Dexfenfluramine, fenfluramine, and phentermine for the treatment of morbid obesity.
Topics: Appetite Depressants; Fenfluramine; Humans; Obesity, Morbid; Patient Selection; Phentermine | 1997 |
Pharmaceutical treatment of obesity.
Topics: Anti-Obesity Agents; Clinical Trials as Topic; Drug Combinations; Fenfluramine; Humans; Obesity; Phentermine | 1997 |
Obesity.
Topics: Appetite Depressants; Behavior; Body Mass Index; Diet, Reducing; Exercise; Female; Fenfluramine; Humans; Obesity; Phentermine; Risk Factors; Weight Loss | 1998 |
Selections from current literature: pharmacological treatment of obesity.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Humans; Hypertension, Pulmonary; Obesity; Phentermine; Selective Serotonin Reuptake Inhibitors | 1998 |
In search of a 'magic' pill to treat obesity: the rise and fall of 'Fen-Phen'.
Topics: Appetite Depressants; Fenfluramine; Humans; Obesity; Phentermine | 1998 |
Challenges in obesity management.
Topics: 1-Naphthylamine; Adrenergic beta-Agonists; Appetite Depressants; Behavior Therapy; Caffeine; Cyclobutanes; Diethylpropion; Ephedrine; Fenfluramine; Fluoxetine; Humans; Lactones; Leptin; Lipase; Obesity; Orlistat; Phentermine; Proteins; Sertraline | 1998 |
Product liability and prescription diet drug cocktail, Fen-Phen: a hard combination to swallow.
Topics: Appetite Depressants; Consumer Product Safety; Drug Combinations; Drug Industry; Fenfluramine; Humans; Liability, Legal; Malpractice; Phentermine; United States; United States Food and Drug Administration | 1998 |
Synergistic interactions between fenfluramine and phentermine.
Topics: Animals; Appetite; Appetite Depressants; Body Weight; Brain; Drug Synergism; Drug Therapy, Combination; Energy Intake; Fenfluramine; Humans; Monoamine Oxidase Inhibitors; Phentermine; Selective Serotonin Reuptake Inhibitors | 1999 |
Current status of fenfluramine/dexfenfluramine-induced cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Dexfenfluramine; Drug Combinations; Endocarditis, Bacterial; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Phentermine; Practice Guidelines as Topic; Prevalence | 1999 |
Obesity drugs and the heart.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine | 1999 |
The serotonergic appetite suppressant fenfluramine. Reappraisal and rejection.
Topics: Appetite; Brain; Cardiovascular Diseases; Fenfluramine; Humans; Phentermine; Selective Serotonin Reuptake Inhibitors; Serotonin | 1999 |
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Nurse Practitioners; Obesity; Phentermine; Practice Guidelines as Topic; Predictive Value of Tests; Prevalence; Risk Factors; Selective Serotonin Reuptake Inhibitors; United States | 1999 |
[Valvular heart disease and primary pulmonary hypertension associated with fenfluramine-phentermine].
Topics: Appetite Depressants; Cardiomyopathies; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine; Selective Serotonin Reuptake Inhibitors | 1998 |
[The obesity epidemics--do diet pills have a place in the treatment?].
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Fenfluramine; Humans; Lactones; Leptin; Obesity; Obesity, Morbid; Orlistat; Phentermine; Selective Serotonin Reuptake Inhibitors; Weight Loss | 2000 |
Appetite suppressants and valvular heart disease.
Topics: Age Factors; Appetite Depressants; Dexfenfluramine; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Multicenter Studies as Topic; Obesity; Phentermine; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration | 2001 |
Appetite suppressants and valvular heart disease - a systematic review.
Topics: Appetite Depressants; Clinical Trials as Topic; Cohort Studies; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 2002 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine; Ultrasonography | 2002 |
Anorexigen-related cardiopulmonary toxicity.
Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine | 2000 |
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Mitral Valve Insufficiency; Phentermine; Serotonin Agents | 2002 |
Anorexigen-induced cardiac valvulopathy and female gender.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Obesity; Phentermine; Serotonin Receptor Agonists | 2003 |
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
Topics: Anti-Bacterial Agents; Antipsychotic Agents; Drug Design; Drug Evaluation, Preclinical; Drug Therapy; Efficiency; Efficiency, Organizational; Fenfluramine; Humans; Neuroprotective Agents; Phentermine; Public Sector; Technology, Pharmaceutical | 2005 |
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
Topics: Animals; Appetite Depressants; Cardiovascular Diseases; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine; Receptor, Serotonin, 5-HT1B; Receptors, Drug | 2005 |
Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases.
Topics: Animals; Appetite Depressants; Disease Models, Animal; Dogs; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Phentermine; Rats; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2008 |
Dopamine/serotonin releasers as medications for stimulant addictions.
Topics: Animals; Behavior, Addictive; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Fenfluramine; Humans; Methamphetamine; Molecular Structure; Neurons; Phentermine; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Substance-Related Disorders | 2008 |
Pharmacologic therapies for obesity.
Topics: Anti-Obesity Agents; Appetite Depressants; Bariatric Surgery; Benzazepines; Bupropion; Cyclobutanes; Ephedrine; Fenfluramine; Humans; Lactones; Naltrexone; Obesity; Orlistat; Phentermine; Weight Gain; Weight Loss | 2010 |
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Incidence; Obesity; Phentermine | 2017 |
22 trial(s) available for phentermine and fenfluramine
| Article | Year |
|---|---|
Clinical aspects of the treatment of obesity by drugs: a review.
Topics: Amphetamines; Appetite Depressants; Clinical Trials as Topic; Diethylpropion; Drug Tolerance; Female; Fenfluramine; Humans; Mazindol; Middle Aged; Obesity; Phenmetrazine; Phentermine | 1979 |
Long-term weight control: the National Heart, Lung, and Blood Institute funded multimodal intervention study.
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fenfluramine; Follow-Up Studies; Humans; National Institutes of Health (U.S.); Obesity; Phentermine; Research Support as Topic; United States; Weight Loss | 1992 |
Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo.
Topics: Adult; Behavior Therapy; Blood Pressure; Body Weight; Diet, Reducing; Double-Blind Method; Exercise; Feeding Behavior; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Phentermine; Pulse; Time Factors; Weight Loss | 1992 |
Long-term weight control study. II (weeks 34 to 104). An open-label study of continuous fenfluramine plus phentermine versus targeted intermittent medication as adjuncts to behavior modification, caloric restriction, and exercise.
Topics: Adult; Behavior Therapy; Blood Pressure; Combined Modality Therapy; Diet, Reducing; Drug Therapy, Combination; Exercise; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Phentermine; Time Factors; Weight Loss | 1992 |
Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine.
Topics: Adult; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Patient Dropouts; Phentermine; Time Factors; Weight Loss | 1992 |
Long-term weight control study. IV (weeks 156 to 190). The second double-blind phase.
Topics: Adult; Behavior Therapy; Body Weight; Diet, Reducing; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Middle Aged; Obesity; Patient Dropouts; Phentermine; Time Factors; Weight Gain | 1992 |
Long-term weight control study. V (weeks 190 to 210). Follow-up of participants after cessation of medication.
Topics: Adult; Behavior Therapy; Body Weight; Diet, Reducing; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Middle Aged; Obesity; Phentermine; Weight Gain | 1992 |
Long-term weight control study. VI. Individual participant response patterns.
Topics: Adult; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Middle Aged; Obesity; Patient Dropouts; Phentermine; Time Factors; Weight Gain; Weight Loss | 1992 |
Long-term weight control study. VII (weeks 0 to 210). Serum lipid changes.
Topics: Adult; Behavior Therapy; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Fenfluramine; Humans; Lipids; Male; Middle Aged; Obesity; Phentermine; Sex Characteristics; Smoking; Time Factors; Triglycerides | 1992 |
Long-term weight control study: conclusions.
Topics: Adult; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, Reducing; Drug Therapy, Combination; Exercise; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Middle Aged; Obesity; Phentermine; Sex Characteristics; Smoking; Time Factors; Triglycerides | 1992 |
Withdrawal depression in obese patients after fenfluramine treatment.
Topics: Adult; Appetite; Appetite Depressants; Depression; Female; Fenfluramine; Humans; Middle Aged; Obesity; Phenethylamines; Phentermine; Placebos; Substance Withdrawal Syndrome; Time Factors | 1972 |
Platelet alpha-adrenergic receptors in obesity: alteration with weight loss.
Topics: Adult; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Phentermine; Platelet Aggregation; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1983 |
A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination.
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Diet; Double-Blind Method; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Patient Compliance; Patient Dropouts; Phentermine | 1984 |
Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers.
Topics: Adult; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Phentermine; Reference Values | 1996 |
Lifestyle modification in the pharmacologic treatment of obesity: a pilot investigation of a potential primary care approach.
Topics: Adult; Affect; Appetite Depressants; Behavior Therapy; Feeding Behavior; Female; Fenfluramine; Humans; Life Style; Lipids; Obesity; Patient Compliance; Phentermine; Physician's Role; Pilot Projects; Psychotherapy, Group; Time Factors; Treatment Outcome; Weight Loss | 1997 |
Pharmacologic induction of weight loss to treat type 2 diabetes.
Topics: Appetite Depressants; Behavior Therapy; Blood Glucose; Blood Pressure; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Fenfluramine; Glycated Hemoglobin; Humans; Lipids; Male; Middle Aged; Obesity; Phentermine; Placebos; Time Factors; Weight Loss | 1999 |
Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine.
Topics: Adrenergic Agents; Adult; Appetite Depressants; Body Mass Index; Double-Blind Method; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Middle Aged; Obesity; Phentermine; Prospective Studies; Randomized Controlled Trials as Topic; Time Factors; Weight Loss | 1999 |
Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramine.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dexfenfluramine; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Northwestern United States; Obesity; Phentermine; Prevalence; Pulmonary Wedge Pressure; Reproducibility of Results; Retrospective Studies; Surveys and Questionnaires | 1999 |
Initial weight loss as a predictor of response to obesity drugs.
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Phentermine; Predictive Value of Tests; Treatment Outcome; Weight Loss | 1999 |
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phentermine; Risk Factors; Selective Serotonin Reuptake Inhibitors; Serotonin; Sympathomimetics; Treatment Outcome | 2000 |
The combination of phentermine and fenfluramine reduced cocaine withdrawal symptoms in an open trial.
Topics: Adult; Central Nervous System Stimulants; Cocaine; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Narcotics; Phentermine; Pilot Projects; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Phentermine; Prevalence; Prospective Studies; Serotonin Receptor Agonists; Statistics, Nonparametric; Ultrasonography | 2001 |
189 other study(ies) available for phentermine and fenfluramine
| Article | Year |
|---|---|
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability.
Topics: Animals; Appetite; Appetite Depressants; Chlorphentermine; Cocaine; Dextroamphetamine; Diethylpropion; Dose-Response Relationship, Drug; Fenfluramine; Haplorhini; Humans; Papio; Phenethylamines; Phenmetrazine; Phentermine; Phenylpropanolamine; Reinforcement, Psychology; Substance-Related Disorders | 1978 |
[CNS- and psycho-activity of the anorectic drugs Phentermine and Fenfluramine: Blood level, quantitative EEG and psychometric analyses (author's transl)].
Topics: Adult; Central Nervous System; Electroencephalography; Female; Fenfluramine; Humans; Male; Middle Aged; Personality; Personality Inventory; Phentermine; Psychometrics | 1977 |
Progressive-ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine.
Topics: Animals; Chlorphentermine; Cocaine; Conditioning, Operant; Diethylpropion; Fenfluramine; Haplorhini; Male; Papio; Phentermine; Reinforcement Schedule; Self Administration | 1978 |
Chlorphentermine may produce dual stimulus effects: a preliminary investigation.
Topics: Animals; Chlorphentermine; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Fenfluramine; Generalization, Stimulus; Male; Phentermine; Rats; Rats, Inbred Strains | 1988 |
Action of fenfluramine, phenylpropanolamine, phentermine and diethylpropion on acoustic startle in rats.
Topics: Acoustic Stimulation; Animals; Appetite Depressants; Body Weight; Diethylpropion; Drug Tolerance; Fenfluramine; Male; Phentermine; Phenylpropanolamine; Rats; Reflex, Startle | 1987 |
[Anorexigenic phenylalkylamines and serotonin metabolism].
Topics: 5-Hydroxytryptophan; Animals; Appetite Depressants; Chlorphentermine; Diarrhea; Eating; Feeding and Eating Disorders; Fenfluramine; Fluorine; Humans; Hypothalamus; Male; Mice; Phenethylamines; Phentermine; Rats; Seizures; Serotonin | 1967 |
Administration of two or more related drugs to investigate the effect of molecular modification and formulation on drug absorption, metabolism and excretion.
Topics: Adult; Amphetamine; Chlorphentermine; Chromatography, Gas; Fenfluramine; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Middle Aged; Phentermine; Structure-Activity Relationship; Time Factors; Urine | 1971 |
The central hypotensive action of amphetamine, ephedrine, phentermine, chlorphentermine and fenfluramine.
Topics: Amphetamine; Animals; Appetite Depressants; Blood Pressure; Cats; Chlorphentermine; Depression, Chemical; Ephedrine; Female; Fenfluramine; Haloperidol; Hypertension; Injections, Intravenous; Male; Phenethylamines; Phentermine; Reserpine; Sympatholytics; Vertebral Artery; Yohimbine | 1972 |
On the effect of anorectic drugs on striatum homovanillic acid in rats.
Topics: Amphetamine; Amphetamines; Animals; Appetite Depressants; Corpus Striatum; Dextroamphetamine; Diethylpropion; Dopamine; Female; Fenfluramine; Homovanillic Acid; Methamphetamine; Phenmetrazine; Phentermine; Phenylacetates; Rats | 1974 |
[Research and experience with fenfluramine in obesity].
Topics: Animals; Cholesterol; Diethylpropion; Fatty Acids, Nonesterified; Feeding Behavior; Fenfluramine; Humans; Male; Mice; Obesity; Phenformin; Phentermine; Triglycerides | 1973 |
Antihypertensive effects of sympathomimetic amines.
Topics: Amines; Amphetamine; Animals; Blood Pressure; Depression, Chemical; Dogs; Ephedrine; Female; Fenfluramine; Heart Rate; Hypertension, Renal; Isoxsuprine; Male; Mecamylamine; Metaraminol; Methamphetamine; Methoxamine; Phenmetrazine; Phentermine; Phenylephrine; Sympathomimetics; Time Factors | 1973 |
Effects of various anorexigenic agents on open field behavior of rats.
Topics: Amphetamine; Animals; Appetite Depressants; Behavior, Animal; Benzphetamine; Fenfluramine; Male; Methamphetamine; Motor Activity; Phenmetrazine; Phentermine; Placebos; Rats; Time Factors | 1973 |
Experimental evaluation of anorexigenic agents in man: a pilot study.
Topics: Adult; Appetite; Appetite Depressants; Body Weight; Diethylpropion; Fenfluramine; Humans; Male; Phenformin; Phentermine | 1972 |
Comparative effects of four antiobesity agents on blood plasma lipids in man.
Topics: Adult; Appetite Depressants; Diethylpropion; Fenfluramine; Humans; Lipids; Male; Phenformin; Phentermine | 1972 |
The possible central stimulant mechanisms of some appetite suppressants.
Topics: Amphetamine; Animals; Appetite Depressants; Catecholamines; Central Nervous System; Chlorphentermine; Diethylpropion; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Fenfluramine; Locomotion; Male; Methamphetamine; Methyltyrosines; Mice; Neurons; Pargyline; Phenethylamines; Phentermine; Rats; Reserpine; Stimulation, Chemical | 1972 |
Comparison of anorexigenic and behavioral potency of phenylethylamines.
Topics: Amphetamine; Animals; Appetite Depressants; Avoidance Learning; Behavior, Animal; Benzphetamine; Chlorine; Chlorphentermine; Diethylpropion; Feeding Behavior; Fenfluramine; Male; Methamphetamine; Morpholines; Phenethylamines; Phenmetrazine; Phentermine; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1972 |
[Behavior of blood pressure during chronic effect of phenylalkylamines].
Topics: Amphetamine; Animals; Appetite Depressants; Blood Pressure; Chlorphentermine; Depression, Chemical; Female; Fenfluramine; Fluorine; Male; Phenethylamines; Phentermine; Rats; Stimulation, Chemical; Time Factors | 1969 |
[Determination of chlorphentermine, fenfluramine and related substances in urine].
Topics: Appetite Depressants; Chlorphentermine; Chromatography, Thin Layer; Dinitrophenols; Fenfluramine; Fluorine; Humans; Phenethylamines; Phentermine; Spectrophotometry | 1967 |
[Influence of anorectics of the amphetamine series on the behavior of the Siamese warrior fish Betta splendens].
Topics: Aggression; Animals; Appetite Depressants; Behavior, Animal; Chlorphentermine; Dextroamphetamine; Fenfluramine; Fishes; Humans; Phentermine | 1966 |
[The excretion of anorectic phenylalkylamines in the urine].
Topics: Animals; Appetite Depressants; Carbamates; Chlorphentermine; Chromatography, Thin Layer; Fenfluramine; Fluorine; Iproniazid; Male; Phenethylamines; Phentermine; Rats | 1966 |
Comparison of the acute physical and mental effects of ephedrine, fenfluramine, phentermine and prolintane.
Topics: Adult; Attention; Blood Pressure; Double-Blind Method; Ephedrine; Fenfluramine; Heart Rate; Hemodynamics; Humans; Learning; Memory; Mental Processes; Phentermine; Psychomotor Performance; Pyrrolidines; Sympathomimetics | 1984 |
The contribution of increased thermogenesis to the effect of anorectic drugs on body composition in mice.
Topics: Animals; Appetite Depressants; Body Composition; Body Temperature Regulation; Diethylpropion; Eating; Energy Metabolism; Female; Fenfluramine; Lipid Metabolism; Mazindol; Mice; Mice, Inbred C57BL; Mice, Obese; Phentermine | 1981 |
Successful appetite suppression therapy with fenfluramine and phentermine in the obese diabetic transplant patient.
Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diabetic Nephropathies; Diet, Reducing; Drug Therapy, Combination; Energy Intake; Fenfluramine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Obesity; Phentermine; Weight Loss | 1995 |
Report on the NIH Workshop on Pharmacologic Treatment of Obesity.
Topics: Animals; Drug Therapy, Combination; Fenfluramine; Humans; Obesity; Phentermine | 1994 |
Fluoxetine (Prozac) and other drugs for treatment of obesity.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Fenfluramine; Fluoxetine; Humans; Obesity; Phentermine | 1994 |
Combined dopamine and serotonin agonists: a synergistic approach to alcoholism and other addictive behaviors.
Topics: Adult; Alcohol Deterrents; Alcoholism; Dopamine Agents; Drug Synergism; Female; Fenfluramine; Humans; Hyperphagia; Male; Middle Aged; Obesity; Phentermine; Serotonin Receptor Agonists | 1993 |
Medications to treat alcoholism?
Topics: Alcohol Deterrents; Alcoholism; Drug Synergism; Fenfluramine; Humans; Phentermine | 1993 |
Smoking cessation in a patient being treated with fenfluramine plus phentermine for simple obesity.
Topics: Adult; Alcohol Drinking; Comorbidity; Drug Therapy, Combination; Fenfluramine; Humans; Male; Obesity; Phentermine; Smoking; Smoking Cessation | 1996 |
Treatment for obesity.
Topics: Adrenergic Uptake Inhibitors; Appetite Depressants; Combined Modality Therapy; Fenfluramine; Humans; Obesity; Phentermine; Selective Serotonin Reuptake Inhibitors | 1996 |
Effects of phentermine and cocaine on fenfluramine-induced depletion of serotonin in mouse brain.
Topics: Animals; Appetite Depressants; Brain; Cocaine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Fenfluramine; Male; Mice; Narcotics; Nerve Degeneration; Norepinephrine; Phentermine; Prosencephalon; Serotonin | 1996 |
New agent for obesity management.
Topics: Appetite Depressants; Fenfluramine; Humans; Obesity; Phentermine | 1996 |
Phentermine+fenfluramine produce cocaine-like discriminative cues.
Topics: Animals; Cocaine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Male; Phentermine; Rats; Rats, Sprague-Dawley | 1996 |
Appetite suppressants for obesity.
Topics: Appetite Depressants; Fenfluramine; Health Status; Humans; Obesity; Phentermine | 1997 |
Appetite-suppressant drugs and primary pulmonary hypertension.
Topics: Adult; Appetite Depressants; Colitis, Ischemic; Drug Therapy, Combination; Female; Fenfluramine; Humans; Phentermine; Sympathomimetics | 1997 |
The pharmacologic management of obesity.
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Body Weight; Chronic Disease; Fenfluramine; Forecasting; Humans; Leptin; Obesity; Phentermine; Proteins; United States; United States Food and Drug Administration | 1997 |
Combined phentermine/fenfluramine administration enhances depletion of serotonin from central terminal fields.
Topics: Animals; Central Nervous System; Drug Combinations; Drug Synergism; Fenfluramine; Hypothalamus; Male; Phentermine; Rats; Rats, Sprague-Dawley; Serotonin | 1997 |
Psychotic mania associated with fenfluramine and phentermine use.
Topics: 1-Naphthylamine; Bipolar Disorder; Depressive Disorder; Female; Fenfluramine; Humans; Middle Aged; Obesity, Morbid; Phentermine; Sertraline | 1997 |
Fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Gastrointestinal Diseases; Humans; Obesity; Phentermine | 1997 |
Phentermine/fenfluramine decreases cocaine self-administration in rhesus monkeys.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fenfluramine; Macaca mulatta; Male; Narcotics; Phentermine; Piperazines; Reaction Time; Self Administration; Serotonin Agents | 1997 |
Behavioural and neurochemical characteristics of phentermine and fenfluramine administered separately and as a mixture in rats.
Topics: Amphetamine; Animals; Cocaine; Discrimination Learning; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Fenfluramine; Illicit Drugs; Male; Microdialysis; Nicotine; Nucleus Accumbens; Phentermine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 1997 |
Anesthetic considerations for the new antiobesity medications.
Topics: Anesthesia, General; Appetite Depressants; Drug Combinations; Fenfluramine; Humans; Hypotension; Phentermine | 1997 |
Mitral valve disease associated with use of anorexigenic medications.
Topics: Appetite Depressants; Fenfluramine; Humans; Mitral Valve Insufficiency; Phentermine | 1997 |
From the Food and Drug Administration.
Topics: Appetite Depressants; Diabetes Mellitus; Emergency Medical Services; Fenfluramine; Heart Valve Diseases; HIV Protease Inhibitors; Humans; Hyperglycemia; Informed Consent; Phentermine; Product Surveillance, Postmarketing; Thalidomide; United States; United States Food and Drug Administration | 1997 |
Report links appetite suppressants with heart disease. FDA encourages reporting of like events.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 1997 |
Cerebral hemorrhage in a patient taking fenfluramine and phentermine for obesity.
Topics: Appetite Depressants; Cerebral Hemorrhage; Drug Combinations; Female; Fenfluramine; Humans; Middle Aged; Obesity; Phentermine; Tomography, X-Ray Computed | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Phentermine; Tricuspid Valve Insufficiency; Ultrasonography | 1997 |
Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Fatal Outcome; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Phentermine; Pulmonary Artery | 1997 |
Diet pills redux.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; Phentermine | 1997 |
Obesity and the diet pill dilemma.
Topics: Appetite Depressants; Central Nervous System Stimulants; Fenfluramine; Humans; Obesity; Phentermine; Selective Serotonin Reuptake Inhibitors | 1997 |
Further cases of valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Middle Aged; Phentermine; Risk Factors | 1997 |
Three cases of comprehensive dietary therapy and pharmacotherapy of patients with complex obesity-related diseases.
Topics: Adult; Aged; Appetite Depressants; Diabetes Mellitus, Type 2; Diet, Reducing; Fatty Liver; Female; Fenfluramine; Hepatitis; Humans; Male; Obesity; Phentermine; Sleep Apnea Syndromes | 1997 |
A dangerous duo? A combination of common diet drugs (fen-phen) may lead to heart valve disease.
Topics: Appetite Depressants; Drug Combinations; Drug Synergism; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Phentermine | 1997 |
Obesity and an abnormal ECG.
Topics: Adult; Appetite Depressants; Drug Combinations; Electrocardiography; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Obesity; Phentermine | 1997 |
Fen-phen and risk of valvular disease.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Risk Factors | 1997 |
Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthesis; Humans; Middle Aged; Phentermine; United States; United States Food and Drug Administration | 1997 |
From the Centers for Disease Control and Prevention. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthesis; Humans; Phentermine; United States; United States Food and Drug Administration | 1997 |
Prepublication release of Journal articles.
Topics: Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Publishing | 1997 |
US journal finds lower risk from diet pills.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Ultrasonography | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Diethylpropion; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Aortic Valve Insufficiency; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Humans; Male; Mitral Valve Insufficiency; Phentermine | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Diabetes Mellitus, Type 2; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hydroxyindoleacetic Acid; Phentermine; Serotonin | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Animals; Appetite Depressants; Drug Evaluation, Preclinical; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; United States; United States Food and Drug Administration | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Bias; Drug and Narcotic Control; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine | 1997 |
In memory of dexfenfluramine: R.I.P.
Topics: Appetite Depressants; Contraindications; Drug Therapy, Combination; Europe; Fenfluramine; Humans; Obesity; Phentermine; United States | 1997 |
Asymptomatic mitral and aortic valve disease is seen in half of the patients taking 'phen-fen'.
Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler, Color; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine | 1998 |
The treatment of obesity with drugs.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; Phentermine | 1998 |
[Drug-clinics. The hue and cry over central appetite suppressants!].
Topics: Adrenergic Agents; Adult; Amphetamines; Appetite; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; Phentermine; Serotonin Agents | 1997 |
Long-term drug treatment of obesity in a private practice setting.
Topics: Adolescent; Adult; Appetite Depressants; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Drug Therapy, Combination; Female; Fenfluramine; Humans; Lipids; Male; Middle Aged; Obesity; Patient Dropouts; Phentermine; Private Practice | 1997 |
Mitral valve disease associated with use of anorexigenic medications.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Mitral Valve; Phentermine | 1998 |
Dentists should exercise caution with fen-phen users.
Topics: Anti-Bacterial Agents; Appetite Depressants; Chemoprevention; Dental Care; Endocarditis, Bacterial; Fenfluramine; Humans; Phentermine; Referral and Consultation | 1997 |
The Phen-Fen no-no with general anesthesia.
Topics: Anesthetics, General; Appetite Depressants; Drug Combinations; Drug Interactions; Fenfluramine; Humans; Phentermine | 1998 |
Unusual hypotension and bradycardia in a patient receiving fenfluramine, phentermine, and fluoxetine.
Topics: Anesthesia, Conduction; Anesthetics, Intravenous; Appetite Depressants; Bradycardia; Drug Interactions; Fenfluramine; Fentanyl; Fluoxetine; Humans; Hypotension; Intraoperative Complications; Male; Middle Aged; Phentermine; Selective Serotonin Reuptake Inhibitors; Sympathomimetics | 1998 |
Valve disease and diet pills--where do we stand?
Topics: Adult; Aged; Aged, 80 and over; Appetite Depressants; Dopamine Agents; Drug Therapy, Combination; Echocardiography; Endocarditis, Bacterial; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Obesity; Phentermine; Serotonin Agents | 1998 |
Delirium with manic symptoms induced by diet pills.
Topics: Adolescent; Bipolar Disorder; Delirium; Drug Therapy, Combination; Female; Fenfluramine; Humans; Middle Aged; Obesity; Phentermine | 1998 |
Combined phentermine/fenfluramine administration and central serotonin neurons.
Topics: Animals; Brain; Drug Combinations; Fenfluramine; Mice; Neurons; Phentermine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin | 1998 |
After fen-phen/Redux: cardiac and pulmonary sequelae implications for patient assessment.
Topics: Adult; Appetite Depressants; Drug Combinations; Emergency Nursing; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Nursing Assessment; Phentermine | 1998 |
Guidelines for users of diet pills.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1998 |
Phen-fen fallout. Financial side effects.
Topics: Appetite Depressants; Echocardiography; Fenfluramine; Health Maintenance Organizations; Heart Valve Diseases; Humans; Liability, Legal; Phentermine; Physicians, Family; Referral and Consultation; United States | 1998 |
Interaction of phentermine plus fenfluramine: neurochemical and neurotoxic effects.
Topics: Adrenergic Agents; Animals; Body Weight; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Agents; Drug Synergism; Fenfluramine; Hippocampus; Hypothalamus; Neostriatum; Phentermine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 1998 |
Endocardial fibrosis associated with fenfluramine-phentermine.
Topics: Adult; Appetite Depressants; Drug Therapy, Combination; Endomyocardial Fibrosis; Female; Fenfluramine; Heart Failure; Humans; Phentermine | 1998 |
Fen-phen's message to dentists.
Topics: Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine | 1998 |
Anorectic drugs and valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Serotonin | 1998 |
The "phen-pro" diet drug combination is not associated with valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine | 1998 |
Efficacy of administration of dexfenfluramine and phentermine, alone and in combination, on ingestive behavior and body weight in rats.
Topics: Animals; Appetite Depressants; Body Weight; Drug Synergism; Feeding Behavior; Fenfluramine; Male; Phentermine; Rats; Rats, Sprague-Dawley | 1998 |
The role of epidemiology in the court.
Topics: Causality; Consumer Product Safety; Expert Testimony; Fenfluramine; Humans; Influenza A virus; Influenza Vaccines; Phentermine; Polyradiculoneuropathy | 1998 |
Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Dopamine Agents; Drug Combinations; Drug Evaluation, Preclinical; Fenfluramine; Limbic System; Male; Mice; Microdialysis; Motor Activity; Phentermine; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin; Serotonin Agents | 1998 |
The fen-phen finale: a study of weight loss and valvular heart disease.
Topics: Adult; Affect; Appetite; Behavior Therapy; Drug Therapy, Combination; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Diseases; Humans; Lipids; Middle Aged; Obesity; Phentermine; Prevalence; Weight Loss | 1998 |
Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine.
Topics: Appetite Depressants; Culture Techniques; Cytochrome P-450 CYP2D6 Inhibitors; Fenfluramine; Humans; Microsomes, Liver; Phentermine | 1998 |
Evaluation of the conditioned reinforcing effects of phentermine and fenfluramine in the rat: concordance with clinical studies.
Topics: Animals; Choice Behavior; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Fenfluramine; Male; Phentermine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 1998 |
Bipolar depression associated with fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Bipolar Disorder; Drug Therapy, Combination; Female; Fenfluramine; Humans; Obesity; Phentermine | 1998 |
Anesthesia risks in patients who have had antiobesity medication.
Topics: Anesthesia, General; Appetite Depressants; Contraindications; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine; Risk; Surgery, Plastic | 1998 |
The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Cross-Sectional Studies; Drug Combinations; Echocardiography, Doppler; Female; Fenfluramine; Humans; Logistic Models; Male; Middle Aged; Mitral Valve Insufficiency; Obesity; Observer Variation; Phentermine; Prevalence | 1998 |
A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinations; Female; Fenfluramine; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Mitral Valve Insufficiency; Obesity; Phentermine; Risk; Survival Analysis | 1998 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 1998 |
Regression of multivalvular regurgitation after the cessation of fenfluramine and phentermine treatment.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine; Remission Induction | 1998 |
Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Appetite Depressants; Biogenic Monoamines; Body Weight; Brain; Dopamine; Drinking Behavior; Drug Interactions; Energy Intake; Feeding Behavior; Fenfluramine; Hydroxyindoleacetic Acid; Male; Mice; Neurons; Neurotoxins; Phentermine; Serotonin | 1998 |
Effects of fenfluramine and phentermine (fen-phen) on dopamine and serotonin release in rat striatum: in vivo microdialysis study in conscious animals.
Topics: Analysis of Variance; Animals; Appetite Depressants; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Combinations; Fenfluramine; Male; Microdialysis; Phentermine; Rats; Rats, Sprague-Dawley; Serotonin | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Middle Aged; Mitral Valve Insufficiency; Phentermine; Risk Factors | 1998 |
Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine.
Topics: Adolescent; Adult; Affect; Aged; Anxiety; Appetite Depressants; Cognition Disorders; Dexfenfluramine; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Memory Disorders; Mental Disorders; Middle Aged; Phentermine; Serotonin Receptor Agonists | 1998 |
Former Fen-Phen users may need prophylactic antibiotic before treatment.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; Endocarditis, Bacterial; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine | 1998 |
Studies confirm link between fen-phen and heart-valve disease.
Topics: Appetite Depressants; Cyclobutanes; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 1998 |
Appetite-suppressant drugs and valvular heart disease.
Topics: Appetite Depressants; Bias; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Odds Ratio; Phentermine; Prevalence | 1999 |
Phentermine and other monoamine-oxidase inhibitors may increase plasma serotonin when given with fenfluramines.
Topics: Analysis of Variance; Animals; Appetite Depressants; Dopamine; Drug Synergism; Fenfluramine; Humans; Male; Monoamine Oxidase Inhibitors; Phentermine; Rats; Serotonin | 1999 |
Effects of dopamine and serotonin-releasing agents on methamphetamine discrimination and self-administration in rats.
Topics: Animals; Discrimination, Psychological; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fenfluramine; Male; Methamphetamine; Phentermine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin Receptor Agonists | 1999 |
After fen-phen.
Topics: Antidepressive Agents, Second-Generation; Appetite Depressants; Consumer Product Safety; Fenfluramine; Fluoxetine; Heart Valve Diseases; Humans; Obesity; Phentermine; Risk Factors; United States; Weight Loss | 1997 |
Severe heart valve disease on appetite suppressants.
Topics: Adult; Appetite Depressants; Case-Control Studies; Diethylpropion; Drug Approval; Drug Combinations; Europe; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Methamphetamine; Obesity; Phenmetrazine; Phentermine; Treatment Outcome; Ultrasonography; United States; United States Food and Drug Administration | 1998 |
Lower dosages of phentermine-fenfluramine given in the afternoon: five cases with significant weight loss.
Topics: Adult; Circadian Rhythm; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Female; Fenfluramine; Humans; Middle Aged; Obesity; Phentermine; Time Factors; Weight Loss | 1999 |
Virus-like particles in the mitral and tricuspid valves explanted from a patient treated with Fenfluramine-Phentermine.
Topics: Adult; Female; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Mitral Valve; Mitral Valve Insufficiency; Phentermine; Tricuspid Valve; Tricuspid Valve Insufficiency | 1999 |
Dose effect of fenfluramine-phentermine in the production of valvular heart disease.
Topics: Appetite Depressants; Diseases in Twins; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Phentermine | 1999 |
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke.
Topics: Aged; Appetite Depressants; Body Mass Index; Case-Control Studies; Cerebrovascular Disorders; Cohort Studies; Dexfenfluramine; Diabetes Complications; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fenfluramine; Humans; Hypercholesterolemia; Hypertension; Male; Obesity; Phentermine; Risk Factors; Smoking | 1999 |
Valvular heart disease in fenfluramine- phentermine-treated patients: a comparison with control patients.
Topics: Appetite Depressants; Body Mass Index; Diet, Reducing; Drug Combinations; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Obesity; Phentermine; Random Allocation; Weight Loss | 1999 |
Anorectic therapy and valvular heart disease: a reappraisal.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Obesity; Phentermine; Serotonin | 1999 |
Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.
Topics: Adult; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Phentermine; Pulmonary Artery; Thrombosis; Vascular Diseases | 1999 |
Differential effects of monoaminergic agonists on alcohol intake in rats fed a tryptophan-enhanced diet.
Topics: Alcohol Drinking; Amphetamine; Animals; Appetite Depressants; Cerebral Cortex; Corpus Striatum; Dopamine; Fenfluramine; Food, Formulated; Hypothalamus; Phentermine; Rats; Rats, Long-Evans; Serotonin; Substance Withdrawal Syndrome; Tryptophan | 1999 |
Valve replacement for appetite suppressant-induced valvular heart disease.
Topics: Adult; Appetite Depressants; Drug Therapy, Combination; Echocardiography, Transesophageal; Female; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Mitral Valve Insufficiency; Phentermine; Time Factors | 1999 |
Anorectic efficacy of the fenfluramine/phentermine combination in rats: additivity or synergy?
Topics: Animals; Anorexia; Appetite Depressants; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Fenfluramine; Food Deprivation; Milk; Phentermine; Rats; Rats, Sprague-Dawley; Regression Analysis; Treatment Outcome | 1999 |
Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Counseling; Dexfenfluramine; Drug Therapy, Combination; Echocardiography; Female; Fenfluramine; Humans; Incidence; Male; Mazindol; Middle Aged; Mitral Valve Insufficiency; Obesity; Observer Variation; Phentermine; Prevalence; Weight Loss | 1999 |
Heart valve lesions in patients treated with appetite suppressants.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Humans; Mitral Valve Insufficiency; Obesity; Phentermine | 1999 |
Sympathetic overactivity from fenfluramine-phentermine overdose.
Topics: Adrenergic Antagonists; Adult; Appetite Depressants; Burns; Drug Combinations; Drug Overdose; Fenfluramine; Humans; Hypnotics and Sedatives; Male; Neuromuscular Blocking Agents; Phentermine; Respiration, Artificial; Respiratory Distress Syndrome; Suicide, Attempted; Sympathetic Nervous System | 1999 |
Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy.
Topics: Adult; Aortic Valve; Appetite Depressants; Dose-Response Relationship, Drug; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Logistic Models; Male; Mitral Valve; Phentermine; Severity of Illness Index | 1999 |
Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota.
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Middle Aged; North Dakota; Phentermine; Risk Factors; Ultrasonography | 1999 |
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Middle Aged; Obesity; Phentermine; Ultrasonography; Weight Loss | 1999 |
Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 months.
Topics: Adult; Appetite Depressants; Echocardiography, Transesophageal; Female; Fenfluramine; Follow-Up Studies; Heart Valve Diseases; Humans; Male; Middle Aged; Phentermine; Risk | 1999 |
Fen/phen and valvular heart disease: if it sounds too bad to be true, perhaps it isn't.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography, Transesophageal; Female; Fenfluramine; Heart Valve Diseases; Humans; Male; Middle Aged; Phentermine; Risk | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Middle Aged; Mitral Valve Insufficiency; Phentermine; Pulmonary Valve Insufficiency; Serotonin Agents; Serotonin Receptor Agonists | 1999 |
Pharmaceutical cost savings of treating obesity with weight loss medications.
Topics: Adolescent; Adult; Appetite Depressants; Caffeine; Cardiovascular Diseases; Diabetes Mellitus; Drug Costs; Ephedrine; Female; Fenfluramine; Humans; Hyperlipidemias; Hypertension; Male; Mazindol; Middle Aged; Obesity; Phentermine; Risk Factors; Weight Loss | 1999 |
Cardiac allograft valvulopathy: a case of donor-anorexigen-induced valvular disease.
Topics: Adult; Appetite Depressants; Disease Progression; Echocardiography; Echocardiography, Doppler; Female; Fenfluramine; Follow-Up Studies; Heart Transplantation; Hemodynamics; Humans; Mitral Valve Insufficiency; Phentermine; Postoperative Complications; Tissue Donors | 1999 |
The fen-phen controversy: is regression another piece of the puzzle?
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1999 |
The need for greater involvement of regulatory agencies in assessing adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Drug Industry; Fenfluramine; Government Agencies; Heart Valve Diseases; Humans; Phentermine; Serotonin Agents | 2000 |
Effects of phentermine and fenfluramine on alcohol consumption and alcohol withdrawal seizures in rats.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Appetite Depressants; Drug Interactions; Drug Therapy, Combination; Eating; Fenfluramine; Male; Phentermine; Rats; Rats, Long-Evans; Selective Serotonin Reuptake Inhibitors; Weight Gain | 2000 |
Supraadditive effect of d-fenfluramine plus phentermine on extracellular acetylcholine in the nucleus accumbens: possible mechanism for inhibition of excessive feeding and drug abuse.
Topics: Acetylcholine; Animals; Appetite Depressants; Dopamine; Drug Synergism; Feeding Behavior; Fenfluramine; Male; Nucleus Accumbens; Phentermine; Rats; Substance-Related Disorders | 2000 |
Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
Topics: Adult; Aged; Amphetamines; Appetite Depressants; Canada; Causality; Cross-Sectional Studies; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Incidence; Male; Middle Aged; Phentermine; Population Surveillance; Prospective Studies; Risk Factors; United States | 2000 |
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Logistic Models; Male; Matched-Pair Analysis; Middle Aged; Mitral Valve Insufficiency; Obesity; Phentermine; Prevalence; Risk; Serotonin Agents; Statistics, Nonparametric | 2000 |
Heart valve disorders and appetite-suppressant drugs.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Serotonin Agents | 2000 |
Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications.
Topics: Amphetamine; Animals; Chlorphentermine; Cocaine; Dopamine; Extracellular Space; Fenfluramine; In Vitro Techniques; Iodine Radioisotopes; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Phentermine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sympathomimetics | 2000 |
Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves.
Topics: Appetite Depressants; Culture Techniques; Extracellular Matrix; Fenfluramine; Gene Expression; Heart Valves; Humans; Phentermine; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Anorectic-induced valvulopathy.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine; Time Factors | 2000 |
Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinations; Female; Fenfluramine; Humans; Logistic Models; Male; Middle Aged; Mitral Valve Insufficiency; Phentermine; Prevalence; Prospective Studies; Ultrasonography | 2000 |
Was the danger of diet pills overstated?
Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 2000 |
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Minnesota; Phentermine; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Ultrasonography | 2000 |
Complex vascular lesions at autopsy in a patient with phentermine-fenfluramin.
Topics: Appetite Depressants; Autopsy; Fatal Outcome; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Middle Aged; Muscle, Smooth, Vascular; Phentermine; Pulmonary Artery | 2000 |
Fen-phen manufacturers, not physicians, are liable.
Topics: Appetite Depressants; Drug Combinations; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Liability, Legal; Malpractice; Obesity; Phentermine; Physicians; Selective Serotonin Reuptake Inhibitors; Texas | 2000 |
Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dose-Response Relationship, Drug; Echocardiography, Doppler, Color; Electrocardiography; Female; Fenfluramine; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Myocardial Contraction; Observation; Observer Variation; Phentermine; Retrospective Studies; Risk Factors; Selective Serotonin Reuptake Inhibitors; Ventricular Function, Right | 2000 |
[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].
Topics: Aged; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; Phentermine; Selective Serotonin Reuptake Inhibitors | 1998 |
Cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Practice Guidelines as Topic; Risk Factors | 2000 |
Simultaneous determination of fenfluramine and phentermine in urine using gas chromatography mass spectrometry with pentafluoropropionic anhydride derivatization.
Topics: Appetite Depressants; Fenfluramine; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Humans; Phentermine | 2000 |
Recent developments in insurance coverage litigation.
Topics: Appetite Depressants; Breast Implants; Environmental Exposure; Fenfluramine; Forecasting; Humans; Insurance Coverage; Latex Hypersensitivity; Lead; Liability, Legal; Pharmaceutical Preparations; Phentermine; United States | 2000 |
The age-adjusted mortality rate from primary pulmonary hypertension, in age range 20 to 54 years, did not increase during the years of peak "phen/fen" use.
Topics: Adult; Age Factors; Appetite Depressants; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phentermine; Population Surveillance; Selective Serotonin Reuptake Inhibitors; United States | 2000 |
Silver lining to the cloud over anorexogen-related cardiac valvulopathy?
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Fenfluramine; Humans; Mitral Valve Insufficiency; Phentermine; Serotonin Agents | 2001 |
Diet drugs and cardiac valvulopathy: a survey of dental patients.
Topics: Adult; Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Endocarditis, Bacterial; Fenfluramine; Follow-Up Studies; Heart Valve Diseases; Humans; Phentermine; Prevalence; Serotonin Agents; Serotonin Receptor Agonists; Surveys and Questionnaires | 2000 |
Bitter pills, bad medicine.
Topics: Anti-Obesity Agents; Drug Therapy, Combination; Fenfluramine; Humans; Liability, Legal; Obesity; Phentermine; United States | 2001 |
Valve disease due to appetite suppressants (cont'd).
Topics: Aortic Valve; Appetite Depressants; Clinical Trials as Topic; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1999 |
The relationship between health-related quality of life and weight loss.
Topics: Adult; Aged; Anti-Obesity Agents; Appetite Depressants; Combined Modality Therapy; Drug Therapy, Combination; Female; Fenfluramine; Health Status; Humans; Male; Middle Aged; Obesity; Phentermine; Physical Fitness; Psychometrics; Quality of Life; Self Concept; Serotonin Agents; Weight Loss | 2001 |
High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride as a label.
Topics: Amines; Animals; Benzoates; Chromatography, High Pressure Liquid; Ephedrine; Fenfluramine; Humans; Imidazoles; Indicators and Reagents; Male; Phenethylamines; Phentermine; Phenylpropanolamine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Sympathomimetics | 2001 |
Operation for anorexigen-associated valvular heart disease.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Phentermine; Serotonin Agents; Serotonin Receptor Agonists; Ultrasonography | 2001 |
Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release.
Topics: Animals; Brain; Cardiovascular Diseases; Fenfluramine; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phentermine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2001 |
Fenfluramine and phentermine.
Topics: Appetite Depressants; Drug Interactions; Drug Therapy, Combination; Fenfluramine; Obesity; Phentermine | 2001 |
Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Fenfluramine; Humans; Male; Norfenfluramine; Phentermine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Stereoisomerism | 2001 |
Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Phentermine; Time Factors | 2001 |
Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Lung; Myocardium; Phentermine | 2002 |
Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Appetite Depressants; Cohort Studies; Drug Therapy, Combination; Female; Fenfluramine; Humans; Infant, Newborn; Phentermine; Pregnancy; Pregnancy Trimester, First; Prospective Studies | 2002 |
Regression and progression of valvulopathy associated with fenfluramine and phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Drug Therapy, Combination; Echocardiography; Fenfluramine; Humans; Middle Aged; Mitral Valve Insufficiency; Phentermine; Remission, Spontaneous; Time Factors | 2002 |
Reversal of Phen-Fen associated valvular regurgitation documented by serial echocardiography.
Topics: Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Phentermine; Recovery of Function | 2002 |
Effects on serotonin in rat hypothalamus of D-fenfluramine, aminorex, phentermine and fluoxetine.
Topics: Aminorex; Animals; Drug Combinations; Fenfluramine; Fluoxetine; Hypothalamus; Male; Phentermine; Rats; Rats, Sprague-Dawley; Serotonin | 2002 |
Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Drug Combinations; Female; Fenfluramine; Humans; Hypertension; Male; Middle Aged; Phentermine | 2002 |
Fen-Phen-noumenon: A mass tort litigation and settlement about to come and go.
Topics: Appetite Depressants; Central Nervous System Stimulants; Fenfluramine; Heart Valve Diseases; Humans; Liability, Legal; Obesity; Phentermine; Serotonin Agents; United States; United States Food and Drug Administration | 2002 |
Morphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography.
Topics: Adult; Aortic Valve; Appetite Depressants; Body Mass Index; Dexfenfluramine; Drug Combinations; Echocardiography, Transesophageal; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle Aged; Mitral Valve; Obesity; Phentermine | 2002 |
Medical monitoring for pharmaceutical injuries: tort law for the public's health?
Topics: Appetite Depressants; Chromans; Dexfenfluramine; Drug Industry; Drug Monitoring; Fenfluramine; Health Policy; Humans; Hypoglycemic Agents; Liability, Legal; Phentermine; Product Surveillance, Postmarketing; Public Health; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2003 |
Effects of preexposure to dexfenfluramine, phentermine, dexfenfluramine-phentermine, or fluoxetine on sibutramine-induced hypophagia in the adult rat.
Topics: Animals; Antidepressive Agents, Second-Generation; Appetite Depressants; Body Weight; Cyclobutanes; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Eating; Fenfluramine; Fluoxetine; Male; Norepinephrine; Phentermine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2003 |
Malpractice. Conviction upheld for doctor who treated AIDS with fen/phen.
Topics: Acquired Immunodeficiency Syndrome; Fenfluramine; Humans; Malpractice; Phentermine | 2003 |
Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats.
Topics: Animals; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Fenfluramine; Injections, Intraperitoneal; Male; Microdialysis; Phentermine; Rats; Rats, Wistar; Reproducibility of Results | 2003 |
The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux.
Topics: Appetite Depressants; Blood Platelets; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Humans; Hydrogen-Ion Concentration; Norfenfluramine; Phentermine; Reserpine; Secretory Vesicles; Selective Serotonin Reuptake Inhibitors; Serotonin | 2003 |
Do these doctors give medicine a black eye?
Topics: Appetite Depressants; Compensation and Redress; Drug Industry; Electrocardiography; Expert Testimony; Fenfluramine; Fraud; Heart Valve Diseases; Humans; Phentermine; United States | 2003 |
Taking things to heart.
Topics: Appetite Depressants; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 2004 |
The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment.
Topics: Adult; Alopecia Areata; Anti-Inflammatory Agents; Appetite Depressants; Brain; Child; Dementia; Female; Fenfluramine; Glucocorticoids; Humans; Hydrocortisone; Magnetic Resonance Imaging; Medical Errors; Neuropsychological Tests; Neurotoxicity Syndromes; Phentermine; Prednisone; Psychoses, Substance-Induced | 2004 |
Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT.
Topics: Adult; Appetite Depressants; Asthma; Drug Combinations; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Hypertrophy; Lung; Obesity; Phentermine; Pulmonary Artery; Radiographic Image Enhancement; Tomography, X-Ray Computed | 2004 |
Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents.
Topics: 4-Butyrolactone; Animals; Appetite Depressants; Behavior, Animal; Blotting, Northern; Cyclobutanes; Dose-Response Relationship, Drug; Fatty Acid Synthases; Fenfluramine; Food Deprivation; Hypothalamus; Immunoblotting; Injections, Intraperitoneal; Injections, Intraventricular; Kinetics; Male; Phentermine; Random Allocation; Rats; Rats, Inbred F344; RNA; Time Factors | 2005 |
Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status.
Topics: Adult; Appetite Depressants; Body Mass Index; Drug Therapy, Combination; Fenfluramine; Fluoxetine; Heart Valve Diseases; Humans; Medical Records; Obesity; Phentermine; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Ultrasonography; Weight Loss | 2007 |
Contingent fees in mass tort litigation.
Topics: Appetite Depressants; Cardiovascular Diseases; Compensation and Redress; Fees and Charges; Fenfluramine; Humans; Liability, Legal; Phentermine; Silicosis; United States | 2006 |
Valvular heart disease with the use of fenfluramine-phentermine.
Topics: Anti-Obesity Agents; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Gastric Bypass; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary; Middle Aged; Obesity; Phentermine | 2011 |
Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat.
Topics: Animals; Appetite Depressants; Dexfenfluramine; Drug Synergism; Eating; Fenfluramine; Male; Phentermine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists | 2015 |
Fenfluramine-Phentermine is Associated with an Increase in Cellular Proliferation Ex Vivo and In Vitro.
Topics: Animals; Anti-Obesity Agents; Aortic Valve; Cardiotoxicity; Case-Control Studies; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Fenfluramine; Heart Valve Diseases; Humans; Myofibroblasts; Phentermine; Proliferating Cell Nuclear Antigen; Serotonin; Signal Transduction | 2017 |
Fifty-seven-year-old man with progressive dyspnoea.
Topics: Appetite Depressants; Diagnosis, Differential; Dyspnea; Echocardiography, Transesophageal; Fenfluramine; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Overweight; Phentermine; Stroke Volume | 2019 |
Weight Loss Supplement-Induced Pulmonary Hypertension: A Decades Delayed Presentation of Fenfluramine-Phentermine.
Topics: Fenfluramine; Humans; Hypertension, Pulmonary; Obesity; Phentermine; Weight Loss | 2023 |