phenserine has been researched along with scopolamine hydrobromide in 7 studies
| Studies (phenserine) | Trials (phenserine) | Recent Studies (post-2010) (phenserine) | Studies (scopolamine hydrobromide) | Trials (scopolamine hydrobromide) | Recent Studies (post-2010) (scopolamine hydrobromide) |
|---|---|---|---|---|---|
| 88 | 6 | 39 | 7,548 | 563 | 1,401 |
| Protein | Taxonomy | phenserine (IC50) | scopolamine hydrobromide (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.003 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.006 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0006 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N | 1 |
| Brossi, A; Garofalo, P; Greig, NH; Heller, B; Iijima, S; Ingram, DK; Spangler, EL | 1 |
| Acevedo, LD; Davis, KL; Gluck, R; Greig, N; Haroutunian, V; Pei, XF; Utsuki, T; Wallace, WC | 1 |
| Cunningham, SC; Devan, BD; Duffy, KB; Greig, NH; Holloway, HW; Ingram, DK; Janas, AM; Markowska, AL; Spangler, EL; Yu, QS | 1 |
| Araujo, JA; Milgram, NW; Studzinski, CM | 1 |
| Greig, NH; Holloway, HW; Ingram, DK; Irie, T; Irikura, M; Mamczarz, J; Moriuchi, H; Spangler, EL; Uchimura, N; Utsuki, T; Yu, QS | 1 |
| Araujo, JA; de Rivera, C; Greig, NH; Ingram, DK; Milgram, NW; Sandin, J | 1 |
1 review(s) available for phenserine and scopolamine hydrobromide
| Article | Year |
|---|---|
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging.
Topics: Acetylcholine; Aging; Animals; Cognition Disorders; Dementia; Disease Models, Animal; Dogs; Humans; Physostigmine; Scopolamine | 2005 |
6 other study(ies) available for phenserine and scopolamine hydrobromide
| Article | Year |
|---|---|
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine | 2010 |
Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Cholinesterase Inhibitors; Electroshock; Male; Maze Learning; Physostigmine; Rats; Rats, Inbred F344; Scopolamine | 1993 |
Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Isoflurophate; Male; Muscarinic Antagonists; Physostigmine; Prosencephalon; Rats; Rats, Sprague-Dawley; Scopolamine | 1997 |
The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats.
Topics: Animals; Cholinesterase Inhibitors; Male; Maze Learning; Physostigmine; Rats; Rats, Inbred F344; Scopolamine | 2005 |
Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy.
Topics: Acetylcholinesterase; Administration, Cutaneous; Animals; Avoidance Learning; Butyrylcholinesterase; Cerebral Cortex; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Cognition; Diffusion Chambers, Culture; Electroshock; Excipients; Male; Muscarinic Antagonists; Ointments; Physostigmine; Rats; Rats, Inbred F344; Scopolamine; Skin Absorption | 2007 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine | 2011 |