phenserine has been researched along with donepezil in 6 studies
| Studies (phenserine) | Trials (phenserine) | Recent Studies (post-2010) (phenserine) | Studies (donepezil) | Trials (donepezil) | Recent Studies (post-2010) (donepezil) |
|---|---|---|---|---|---|
| 88 | 6 | 39 | 3,193 | 557 | 1,594 |
| Protein | Taxonomy | phenserine (IC50) | donepezil (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.4231 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.0265 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.022 | |
| Cholinesterase | Homo sapiens (human) | 4.5742 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 7.42 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 5 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 7.4 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 1.5489 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.3257 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.1644 | |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | 0.0053 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.0182 | |
| Beta-secretase 1 | Homo sapiens (human) | 0.8666 | |
| Cholinesterase | Equus caballus (horse) | 3.7325 | |
| Cholinesterase | Mus musculus (house mouse) | 1.992 | |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | 0.0324 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.7844 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 4.715 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 4.5551 | |
| Histamine H3 receptor | Homo sapiens (human) | 0.35 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X | 1 |
| Alley, GM; Brossi, A; Deschamps, JR; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, D; Yu, QS; Zhan, M | 1 |
| Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N | 1 |
| Li, J; Liu, D; Liu, W; Shi, T; Wang, D; Wang, Y; Wang, Z; Yin, G; Zhang, H | 1 |
| Araujo, JA; de Rivera, C; Greig, NH; Ingram, DK; Milgram, NW; Sandin, J | 1 |
| Darreh-Shori, T; Hosseini, SM; Nordberg, A | 1 |
1 trial(s) available for phenserine and donepezil
| Article | Year |
|---|---|
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors | 2014 |
5 other study(ies) available for phenserine and donepezil
| Article | Year |
|---|---|
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship | 2002 |
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.
Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Benzofurans; Butyrylcholinesterase; Carbamates; Cell Line; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neurons; Oxepins; Structure-Activity Relationship | 2005 |
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine | 2010 |
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Drug Design; Humans; Male; Maze Learning; Molecular Docking Simulation; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tryptamines | 2022 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine | 2011 |