phenprocoumon and tiaprofenic-acid

The study deals with the clinical and pharmacokinetic interaction of tiaprofenic acid (Surgam) and phenprocoumon. 6 healthy volunteers received phenprocoumon p.o. with a view to decreasing Quick's value. After the first administration a pharmacokinetic profile of phenprocoumon was taken. As Quick's value dropped to 37% at the 4th day of the study, the subjects received tiaprofenic acid additionally. Afterwards the pharmacokinetic profiles of phenprocoumon and tiaprofenic acid were taken again. The study led to the following results: 1. The clotting parameters are not changed on synchronous administration of tiaprofenic acid and phenprocoumon. 2. The pharmacokinetic profile of tiaprofenic acid is not changed by pretreatment with phenprocoumon. 3. The parmacokinetic profile of phenprocoumon is not changed by tiaprofenic acid.

Topics: 4-Hydroxycoumarins; Adult; Blood Coagulation; Drug Interactions; Humans; Phenprocoumon; Propionates; Thiophenes