phenobarbital-sodium and pyrrolidin-3-yl-methanesulfonic-acid

phenobarbital-sodium has been researched along with pyrrolidin-3-yl-methanesulfonic-acid* in 1 studies

Other Studies

1 other study(ies) available for phenobarbital-sodium and pyrrolidin-3-yl-methanesulfonic-acid

Article	Year
Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition. Brain research, 1999, Oct-02, Volume: 843, Issue:1-2 Folates have been shown to be neurotoxic and convulsive. Endogenously, folates exist in the brain in a polyglutamated form with 1-7 terminal glutamates (approx. 1 microM). The brain enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase) has been shown to remove sequentially the gamma-linked glutamates from folic acid polyglutamates. We report that, at high concentrations (300 microM-30 mM), a folic acid hexaglutamate analog is dose-dependently toxic to dissociated rat cortical cultures and that this toxicity is reversed by 2-PMPA, a potent and selective NAALADase inhibitor. These data suggest a new mechanism for folic acid toxicity. Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Carboxypeptidases; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fetus; Glutamate Carboxypeptidase II; Glycine; Methotrexate; N-Methylaspartate; Neurons; Neurotoxins; Organophosphorus Compounds; Potassium Cyanide; Pyrrolidines; Rats	1999

Article

Year

Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.

Brain research, 1999, Oct-02, Volume: 843, Issue:1-2

Folates have been shown to be neurotoxic and convulsive. Endogenously, folates exist in the brain in a polyglutamated form with 1-7 terminal glutamates (approx. 1 microM). The brain enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase) has been shown to remove sequentially the gamma-linked glutamates from folic acid polyglutamates. We report that, at high concentrations (300 microM-30 mM), a folic acid hexaglutamate analog is dose-dependently toxic to dissociated rat cortical cultures and that this toxicity is reversed by 2-PMPA, a potent and selective NAALADase inhibitor. These data suggest a new mechanism for folic acid toxicity.

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Carboxypeptidases; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fetus; Glutamate Carboxypeptidase II; Glycine; Methotrexate; N-Methylaspartate; Neurons; Neurotoxins; Organophosphorus Compounds; Potassium Cyanide; Pyrrolidines; Rats

1999