phenobarbital has been researched along with warfarin in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 127 (68.28) | 18.7374 |
| 1990's | 27 (14.52) | 18.2507 |
| 2000's | 20 (10.75) | 29.6817 |
| 2010's | 11 (5.91) | 24.3611 |
| 2020's | 1 (0.54) | 2.80 |
| Authors | Studies |
|---|---|
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Erdmann, F; Fischer, G; Harris, R; Hopkins, S; Huang, Z; Murray, MG; Ribeill, Y; Scorneaux, B; Smitley, C; Wring, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Lichtenberger, F; Nastainczyk, W; Ullrich, V | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 2 |
| Blaschke, TF; Esquivel, M; Meffin, PJ; Snidow, GH | 1 |
| Levy, G; Slattery, JT; Yacobi, A | 3 |
| Feuer, G; Kellen, JA; Kovacs, K | 2 |
| Pelkonen, O; Raunio, H | 1 |
| Imai, Y | 1 |
| Oesch, F; Tunek, A | 1 |
| Hietanen, E; Pelkonen, K | 1 |
| Breckenridge, A | 1 |
| Glatt, HR; Oesch, F; Raphael, D; Schwind, H | 1 |
| Wood, AW | 1 |
| Bridges, JW; Fry, JR; Kao, J; Shirkey, RJ | 1 |
| Kajfez, F; Rendić, S; Ruf, HH; Sunjić, V; Toso, R | 1 |
| Greenlee, WF; Poland, A | 1 |
| Coon, MJ; Fasco, MJ; Kaminsky, LS; Vatsis, KP | 1 |
| Duppel, W; Ullrich, V | 1 |
| Yang, CS | 1 |
| Pohl, LR; Porter, WR; Trager, WF | 1 |
| Burns, JJ; Conney, AH; Kamm, JJ; Kuenzig, W; Tkaczevski, V | 1 |
| Levin, W; Lu, AY; Miwa, GT; Ryan, D; Thomas, PE; West, SB | 1 |
| Mathur, PP; Procaccini, RL; Reavey-Cantwell, NH; Smyth, RD | 1 |
| Assandri, A; Perazzi, A | 1 |
| Glogner, P; Heni, N; Lehnhardt, G | 1 |
| Phillips, WA; Ratchford, JM; Schultz, JR | 1 |
| Breckenridge, A; Orme, M | 2 |
| Anderson, J; Bray, PF; Nievel, JG | 1 |
| Nievel, JG | 2 |
| Anderson, J; Nievel, JG; Robinson, N | 1 |
| Anderson, J; Nievel, JG; Skrbic, TR | 1 |
| Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH | 1 |
| Udall, JA | 1 |
| Ullrich, V; Weber, P; Wollenberg, P | 1 |
| Herczeg, T; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD | 1 |
| Kato, S; Yamamoto, K | 2 |
| Aitio, ML; Arvela, P; Bartsch, H; Béréziat, JC; Hietanen, E | 1 |
| Apanovitch, D; Kitareewan, S; Walz, FG | 1 |
| Baker, MT; Ronnenberg, WC | 1 |
| Gann, KL; Jauregui, HO; Ng, SF; Waxman, DJ | 1 |
| Fentem, JH; Fry, JR; Hammond, AH | 1 |
| Groh, T; Müller, D; Splinter, FK | 1 |
| Hermans, JJ; Thijssen, HH | 1 |
| Fentem, JH; Fry, JR | 1 |
| Baker, MT; Chiang, CK; Vasquez, MT | 1 |
| Fujino, T; Gelboin, HV; Park, SS; West, D | 1 |
| Boothby, M; Davies, JA; Feely, MP; Haigh, JR; Joanes, DN; Kumar, S; Roberts, BE; Tate, G | 1 |
| Gibson, GG; MacNicoll, AD; Sutcliffe, FA | 1 |
| Heubel, F; Netter, KJ; Vesell, ES | 1 |
| Gerstner, E; Heubel, F; Reuter, T | 1 |
| Isobe, M; Ozawa, N; Sone, T; Takabatake, E; Watabe, T | 1 |
| Davies, JA; Feely, MP; Haigh, JR; Kumar, S; Roberts, BE | 1 |
| Legrum, W; Meyer, S | 1 |
| Davies, JA; Feely, MP; Haigh, JR; Kumar, S; Peaker, S; Rhodes, LE; Roberts, BE | 1 |
| Baciewicz, AM | 1 |
| Brüch, M; Kling, L; Legrum, W; Maser, E | 1 |
| Bradford, L; Calvert, R; Cooke, J; Feely, M; Mehta, A; Price, D; Singleton, S | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
| White, IN | 1 |
| Akhrem, AA; Chashchin, VL; Iuvonen, RO; Lang, MA; Shkumatov, VM | 1 |
| Karge, E; Klinger, W | 1 |
| Graf, H; Jung, B; Ullrich, V | 1 |
| Adams, DJ; Dawson, JR; Wolf, CR | 1 |
| Kling, L; Legrum, W; Netter, KJ | 1 |
| Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET | 1 |
| Greiling, H; Greiling, K; Klinger, W; Müller, D | 1 |
| Adams, DJ; Amelizad, Z; Oesch, F; Seilman, S; Wolf, CR | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G | 1 |
| La Du, BN | 1 |
| Jatlow, P | 1 |
| Scharf, R; Ullrich, V | 2 |
| Lehrmann, C; Rummel, W; Ullrich, V | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Ullrich, V; Weber, P | 2 |
| Kon, H; Nebert, DW; Robinson, JR | 1 |
| Kellaway, GS; McCrae, E | 1 |
| Aitio, A; Vainio, H | 1 |
| Hänninen, O; Vainio, H | 1 |
| Burchell, B | 1 |
| Feuer, G; Liscio, A | 2 |
| Feuer, G; Granda, V | 1 |
| Cooper, SD; Feuer, G | 2 |
| Feuer, G; Kellen, JA | 1 |
| Conney, AH; Wood, AW | 1 |
| Diaugustine, RP; Eling, TE; Fouts, JR | 1 |
| Conney, AH; Jacobson, M; Levin, W; Poppers, PJ; Wood, AW | 1 |
| Glogner, P; Heni, N; Lenhardt, G | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G; Miller, DR | 1 |
| Chan, KK; Lewis, RJ; Robinson, AJ; Trager, WF | 1 |
| Jacobs, HD | 1 |
| Breckenridge, A; Davies, DS; Davies, L; Orme, M | 1 |
| Basu, TK; Dickerson, JW; Parke, DV | 1 |
| Frommer, U; Ullrich, V; Weber, P | 1 |
| Blank, H | 1 |
| Kratz, F | 1 |
| Jähnchen, E; Levy, G | 1 |
| Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC | 1 |
| Winsnes, A | 1 |
| Abrams, WB; Reich, S; Solomon, HM; Spirt, N | 1 |
| Frei, J; Magnenat, P; Okolicsanyi, L | 1 |
| Black, M | 1 |
| Brody, BB | 1 |
| Kratz, F; Staudinger, H | 2 |
| Burns, JJ; Conney, AH; Ikeda, M | 1 |
| Golberg, L; Nievel, JG | 1 |
| MacDonald, MG; Robinson, DS | 1 |
| Duckert, F; Seiler, K | 1 |
| Bailey, KR; Gallo, DG; Sheffner, AL | 1 |
| Nahum, LH | 1 |
| Corn, M | 1 |
| Taylor, PJ | 1 |
| Kuhnz, W; Luck, W; Nau, H; Wegener, S | 1 |
| Imai, Y; Komori, M; Sato, R | 1 |
| Fry, JR; Horner, SA; Paterson, P | 1 |
| Betnér, I; Halpert, J; Näslund, B | 1 |
| Bachmann, KA; Sullivan, TJ | 1 |
| Crisp, DN; Orton, TC; Sorman, AE; Sturdee, AP | 1 |
| Dannan, GA; Guengerich, FP; Kaminsky, LS | 1 |
| Hines, RN; Nelson, RE; Prough, RA; Sieg, MS; Wiebkin, P | 1 |
| Goldberg, DM | 1 |
| Bint, AJ; Burtt, I | 1 |
| Bush, ED; Trager, WF | 1 |
| Porter, WR; Trager, WF; Wheeler, C | 1 |
| Fasco, MJ; Kaminsky, LS; McMartin, DN; O'Connor, JA | 1 |
| Cashin, MJ; Fasco, MJ | 1 |
| Bracken, W; Bullock, P; Draper, A; Parkinson, A; Pearce, R; Podval, J; Thomas, P; Veltman, J | 1 |
| Clement, B; Mladek, C | 1 |
| Bunch, AW; Fernandez-Salguero, P; Gutierrez-Merino, C | 1 |
| Hirata, M; Nishibe, Y | 1 |
| Bartsch, H; Kirby, GM; Lang, MA; Pelkonen, P; Wild, CP | 1 |
| Desager, JP; Harvengt, C; Horsmans, Y | 1 |
| Evans, JG; Lake, BG | 1 |
| Grimm, SW; Halpert, JR; Kedzie, KM; Philpot, RM; Ryan, R | 1 |
| Blaauboer, BJ; Luijckx, NB; Mennes, WC; Noordhoek, J; Wortelboer, HM | 1 |
| Jansson, I; Schenkman, JB | 1 |
| Ashwood-Smith, MJ; Baer-Dubowska, W; Cai, Y; Ceska, O; DiGiovanni, J; Tachibana, S | 1 |
| Fry, JR; Garle, MJ; Giurnazi, AM; Lal, K | 1 |
| Chikaoka, Y; Tamura, M | 1 |
| Carlile, DJ; Hakooz, N; Houston, JB | 1 |
| Ball, HW; Manson, MM; McLellan, LI; Shepherd, AG | 1 |
| Evans, DC; Lake, BG; Meneses-Lorente, G; Price, RJ; Renwick, AB; Surry, D | 1 |
| Ciccone, A; Citterio, A; Santilli, I; Sterzi, R | 1 |
| Finch, RA; Fort, DJ; Rogers, RL; Stover, EL | 1 |
| Evans, DC; Lake, BG; Lavignette, G; Lewis, DF; Price, RJ; Renwick, AB; Surry, D; Williams, B; Worboy, PD | 1 |
| Rosen, GM; Thohan, S | 1 |
| BURNS, JJ; CONNEY, AH | 1 |
| OSCHAROFF, A | 1 |
| Bass, AE; Bruce, G; Bylov, IE; Fry, JR; Hammond, AH; Jassi, KL; Kovalenko, SM; Laughton, C; Shaw, PN | 1 |
| Friis, C; Gillberg, M; Skaanild, MT | 1 |
| Commandeur, JN; Irth, H; Kool, J; van Elswijk, DA; van Liempd, SM; van Rossum, H; Vermeulen, NP | 1 |
| Etzrodt, J; Glöckner, R; Lupp, A; Müller, D | 1 |
| Gharaibeh, SF; Tahaineh, LM | 1 |
| Li, W; Yang, XW; Zhang, YB | 1 |
| Kuehni-Boghenbor, K; Mevissen, M; Möller, AM; Schmitz, A; Stefanski, A | 1 |
| Bezerra, A; de Bairros, AV; Dias, D; Klein, B; Kommers, G; Miguel Pego, A; Stefanon, E; Wagner, R | 1 |
| Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ | 1 |
9 review(s) available for phenobarbital and warfarin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Clinical implications of enzyme induction.
Topics: Animals; Barbiturates; Bile; Bilirubin; Digitoxin; Enzyme Induction; gamma-Glutamyltransferase; Glucuronosyltransferase; Humans; Hydrocortisone; Hyperbilirubinemia, Hereditary; Kinetics; Liver; Microsomes, Liver; Organ Specificity; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Sulfobromophthalein; Time Factors; Warfarin | 1975 |
Carbamazepine drug interactions.
Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin | 1986 |
Pharmacogenetics: defective enzymes in relation to reactions to drugs.
Topics: Acetylation; Cholinesterases; Coumarins; Dicumarol; Dose-Response Relationship, Drug; Female; Genetic Code; Genetic Diseases, Inborn; Glucosephosphate Dehydrogenase Deficiency; Humans; Isoniazid; Male; Metabolism, Inborn Errors; Pharmacogenetics; Phenacetin; Phenobarbital; Phenytoin; Succinylcholine | 1972 |
The actions and interactions of drugs: the therapeutic significance of enzyme induction.
Topics: Aging; Animals; Child; Chloral Hydrate; Dogs; Drug Antagonism; Drug Resistance, Microbial; Endoplasmic Reticulum; Enzyme Induction; Female; Genetics, Microbial; Griseofulvin; Humans; Hypnotics and Sedatives; Infant, Newborn; Insecticides; Lupus Erythematosus, Systemic; Male; Mice; Microscopy, Electron; Microsomes; Molecular Biology; Penicillinase; Phenobarbital; Porphyrias; Rabbits; Rats; Steroids; Warfarin | 1967 |
[On the problem of foreign substances detoxification through the liver].
Topics: Benzopyrenes; Body Weight; Carbon Monoxide Poisoning; Coumarins; Endoplasmic Reticulum; Freeze Drying; Humans; Insecticides; Liver; Microsomes; Mixed Function Oxygenases; Phenobarbital; Poisoning; Proteins | 1968 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin | 1980 |
Adverse antibiotic drug interactions.
Topics: Aminosalicylic Acid; Antacids; Anti-Bacterial Agents; Biological Availability; Contraceptives, Oral; Digitoxin; Drug Interactions; Gastrointestinal Motility; Humans; Hydrogen-Ion Concentration; Kidney; Metals; Phenobarbital; Phenytoin; Rifampin; Sulfonamides; Tetracyclines; Warfarin | 1980 |
THERAPEUTIC IMPLICATIONS OF DRUG METABOLISM.
Topics: Aminopyrine; Chloramphenicol; Coumarins; Dicumarol; Humans; Metabolism; Pharmaceutical Preparations; Pharmacology; Phenacetin; Phenobarbital; Phenylbutazone | 1964 |
2 trial(s) available for phenobarbital and warfarin
| Article | Year |
|---|---|
Clinical evaluation of side-effects of drugs.
Topics: Accident Prevention; Aged; Anti-Bacterial Agents; Anticoagulants; Carbamazepine; Dibenzazepines; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Evaluation Studies as Topic; Female; Humans; Length of Stay; Male; Middle Aged; Migraine Disorders; Pharmaceutical Preparations; Phenobarbital; Placebos; Warfarin | 1973 |
Effect of phenobarbital and glutethimide on biological half-life of warfarin.
Topics: Female; Glutethimide; Humans; Male; Middle Aged; Phenobarbital; Warfarin | 1966 |
175 other study(ies) available for phenobarbital and warfarin
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cyclophilin A; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Haplorhini; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukocytes, Mononuclear; Mice; Molecular Structure; Rats; RNA, Viral; Virus Replication | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Cytochrome P450 as an oxene transferase.
Topics: Anaerobiosis; Animals; Benzene Derivatives; Benzopyrenes; Coumarins; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethyl Ethers; Hot Temperature; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature; Transferases | 1976 |
Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Catalysis; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethyl Ethers; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats | 1978 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
Effect of phenobarbitone on the disposition of lignocaine and warfarin in the dog.
Topics: Animals; Biological Availability; Dogs; Drug Interactions; Lidocaine; Liver Circulation; Phenobarbital; Time Factors; Warfarin | 1978 |
Comparative pharmacokinetics of coumarin anticoagulants XXIV: Effect of treatment with phenobarbital on serum protein binding of warfarin and dicumarol in rats.
Topics: Animals; Blood Proteins; Dicumarol; Kinetics; Male; Phenobarbital; Protein Binding; Rats; Warfarin | 1977 |
Is there any association between the pharmacologic control of prolactin release and its action on mammary carcinogenesis in the rat?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbon Tetrachloride; Coumarins; Female; Mammary Neoplasms, Experimental; Phenobarbital; Prolactin; Rats | 1977 |
The inhibition of induction of microsomal monooxygenase activity by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Carboxy-Lyases; Coumarins; Cytochrome P-450 Enzyme System; Diamines; Enzyme Induction; Ethyl Ethers; Female; Flavonoids; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Naphthalenes; Ornithine Decarboxylase Inhibitors; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Propanolamines; Rats | 1979 |
Reconstituted O-dealkylase systems containing various forms of liver microsomal cytochrome P-450.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Rabbits; Rats; Spectrophotometry | 1979 |
Unique behaviour of benzene mono-oxygenase: activation by detergent and different properties of benzene- and phenobarbital-induced mono-oxygenase activities.
Topics: Animals; Benzene; Coumarins; Cytochrome P-450 Enzyme System; Detergents; Enzyme Activation; In Vitro Techniques; Male; Metyrapone; Oxygenases; Phenobarbital; Phenols; Rats | 1979 |
Hepatic and extrahepatic induction of drug-metabolizing enzymes in specific pathogen free and germ free rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethyl Ethers; Germ-Free Life; Glucuronosyltransferase; Intestinal Mucosa; Kidney; Liver; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Oxidoreductases, O-Demethylating; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms | 1979 |
Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.
Topics: Animals; Benzopyrenes; Biotransformation; Coumarins; Epoxide Hydrolases; Female; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Mutagens; Oxidoreductases; Phenobarbital; Rats; Salmonella typhimurium; Species Specificity | 1977 |
Genetic regulation of coumarin hydroxylase activity in mice. Biochemical characterization of the enzyme from two inbred strains and their F1 hybrid.
Topics: Aniline Compounds; Animals; Coumarins; Crosses, Genetic; Kinetics; Male; Metyrapone; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Species Specificity; Substrate Specificity | 1979 |
A comparison of xenobiotic metabolism in cells isolated from rat liver and small intestinal mucosa.
Topics: Aniline Compounds; Animals; Benzoates; Biotransformation; Coumarins; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Liver; Male; Methylcholanthrene; Phenobarbital; Phenols; Rats; Time Factors | 1979 |
Interaction of cimetidine with liver microsomes.
Topics: Animals; Binding, Competitive; Cimetidine; Coumarins; Cytochrome P-450 Enzyme System; Guanidines; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats | 1979 |
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Dioxins; Enzyme Induction; Ethyl Ethers; Kinetics; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oxygenases; Phenobarbital; Polychlorinated Dibenzodioxins; Spectrometry, Fluorescence | 1978 |
Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Flavonoids; Hydroxylation; Isomerism; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Phenobarbital; Rabbits; Structure-Activity Relationship; Warfarin | 1978 |
Is there any association between elevated serum prolactin level and mammary adenocarcinoma induced by 7,12-dimethylbenz(alpha)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Benz(a)Anthracenes; Coumarins; Female; Liver; Mammary Neoplasms, Experimental; Mixed Function Oxygenases; Phenobarbital; Prolactin; Rats; Stimulation, Chemical | 1975 |
Membrane effects on drug monooxygenation activity in hepatic microsomes.
Topics: Animals; Calorimetry; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Induction; Ethyl Ethers; Male; Membranes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Temperature; Thermodynamics | 1976 |
Interactions between solubilized cytochrome P-450 and hepatic microsomes.
Topics: Animals; Binding Sites; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Protein Binding; Rats; Solubility | 1977 |
Stereochemical biotransformation of warfarin as a probe of the homogeneity and mechanism of microsomal hydroxylases.
Topics: Animals; Biotransformation; Cytochromes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proteins; Rats; Stereoisomerism; Time Factors; Warfarin | 1977 |
The effect of ascorbic acid deficiency on extrahepatic microsomal metabolism of drugs and carcinogens in the guinea pig.
Topics: Animals; Ascorbic Acid Deficiency; Carcinogens; Coumarins; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Lung; Male; Microsomes; Microsomes, Liver; Pharmaceutical Preparations; Phenobarbital | 1977 |
Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.
Topics: Animals; Antibodies; Benzopyrenes; Benzphetamine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; In Vitro Techniques; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Phenobarbital; Rats; Testosterone | 1977 |
Binding of R and S warfarin to hepatic microsomal cytochrome P-450.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Warfarin | 1977 |
Comparative effect of phenobarbital and methaqualone on warfarin metabolism in the rat.
Topics: Animals; Enzyme Induction; Male; Methaqualone; Microsomes, Liver; Phenobarbital; Rats; Warfarin | 1976 |
Competition between diftalone and other drugs for the binding site(s) on human serum albumin.
Topics: Acetaminophen; Aspirin; Binding Sites; Dexamethasone; Drug Interactions; Humans; Indomethacin; Phenobarbital; Phenylbutazone; Phthalazines; Protein Binding; Pyridazines; Serum Albumin; Temperature; Tolbutamide; Warfarin | 1976 |
[Elimination kinetics of phenprocoumon (Marcumar) in liver cirrhosis and after premedication with phenobarbital].
Topics: Adult; Aged; Coumarins; Humans; Kinetics; Liver Cirrhosis; Male; Middle Aged; Phenobarbital; Phenprocoumon; Protein Binding | 1976 |
Effects of colestipol hydrochloride on drug absorption in the rat II.
Topics: Animals; Cellulose; Chlorpromazine; Cholestyramine Resin; Clofibrate; Colestipol; Digitoxin; Digoxin; Hydrochlorothiazide; Intestinal Absorption; Male; Nicotinic Acids; Pharmaceutical Preparations; Phenobarbital; Polyamines; Rats; Tetracycline; Warfarin | 1976 |
Enantiomers of warfarin and phenobarbital.
Topics: Drug Interactions; Humans; Isomerism; Phenobarbital; Warfarin | 1976 |
Biochemical changes in liver and blood underlying parenchymal damage of rat liver induced by a dose-dependent effect of drugs before and after development of liver enlargement and nodular hyperplasia.
Topics: Animals; Butylated Hydroxytoluene; Coumarins; Cresols; Female; Hyperplasia; Liver; Phenobarbital; Protein Biosynthesis; Rats | 1976 |
Studies on the relationship between effects on membranes and ribosomal aggregates in high-power electron micrography and on macromolecular synthesis induced by drugs and environmental chemicals.
Topics: Animals; Butylated Hydroxytoluene; Cell Membrane; Coumarins; Cresols; Endoplasmic Reticulum; Female; Liver; Microscopy, Electron; Phenobarbital; Polyribosomes; Protein Biosynthesis; Rats; Transcription, Genetic | 1976 |
Changes in nucleotide metabolism of the liver and fate of [14C]orotate among various pyrimidines at the outset and during induction of drug-metabolizing enzymes and hepatomegaly.
Topics: Animals; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; DNA Replication; Enzyme Induction; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Protein Biosynthesis; Rats; Ribonucleotides; Transcription, Genetic; Uracil | 1976 |
Studies on the relationship between induction of drug-metabolizing enzymes, liver enlargement and ascorbic acid excretion in rodents.
Topics: Animals; Ascorbic Acid; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucuronates; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Proadifen; Rats; Transcription, Genetic; Uracil; Uracil Nucleotides | 1976 |
Decreased capacity to metabolize diphenylhydantoin in a patient with hypersensitivity to warfarin.
Topics: Half-Life; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Phenobarbital; Phenytoin; Warfarin | 1975 |
Clinical implications of warfarin interactions with five sedatives.
Topics: Administration, Oral; Adult; Aged; Blood Coagulation; Chloral Hydrate; Drug Interactions; Glutethimide; Humans; Male; Methaqualone; Middle Aged; Phenobarbital; Prothrombin Time; Secobarbital; Warfarin | 1975 |
Tetrahydrofurane - an inhibitor for ethanol-induced liver microsomal cytochrome P450.
Topics: Animals; Benzopyrenes; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Ethanol; Ethyl Ethers; Female; Flavonoids; Furans; Male; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Rats | 1975 |
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Enzyme Induction; Hexobarbital; Hypoprothrombinemias; Liver; Male; Methaqualone; Phenobarbital; Proadifen; Prothrombin Time; Rats; Sleep; Time Factors; Warfarin | 1976 |
Comparative effects of chloroflavone congeners as inducers of hepatic microsomal monooxygenases in rats.
Topics: Aminopyrine N-Demethylase; Animals; Coumarins; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism | 1992 |
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital.
Topics: Animals; Antipyrine; Debrisoquin; Diethylnitrosamine; Liver; Male; Microsomes, Liver; Neoplasms, Experimental; Organ Size; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism; Warfarin | 1992 |
Exocyclic-keto reductase activities for progesterone and S-warfarin in hepatic microsomes from adult male rats.
Topics: 20-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Animals; Cytochrome P-450 Enzyme System; Female; Male; Microsomes, Liver; NAD; NADP; Phenobarbital; Progesterone; Rats; Rats, Inbred Strains; Sex Characteristics; Species Specificity; Warfarin | 1992 |
Acute stimulation of trifluoroethene defluorination and cytochrome P450 inactivation in the rat by exposure to isoflurane.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Fluorides; Hydrocarbons, Fluorinated; Isoflurane; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Warfarin | 1992 |
Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Xenobiotics | 1991 |
Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures.
Topics: Animals; Benzopyrans; Cell Death; Cells, Cultured; Coumarins; Cytochrome P-450 Enzyme System; Gerbillinae; Liver; Male; Mixed Function Oxygenases; Phenobarbital | 1991 |
Influence of inducers of cytochrome P-450 on dealkylation of 7-alkoxycoumarins.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Male; Phenobarbital; Rats | 1991 |
Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4'-nitrowarfarin (acenocoumarol).
Topics: Acenocoumarol; Animals; Chromatography, High Pressure Liquid; Cimetidine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism; Warfarin | 1991 |
Effect of cimetidine on the metabolism of coumarin by rat, gerbil and human liver microsomes.
Topics: Animals; Cimetidine; Coumarins; Drug Interactions; Gerbillinae; Humans; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Rats; Rats, Inbred Strains; Umbelliferones | 1991 |
Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Halothane; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Warfarin | 1991 |
Studies on the mechanism of monoclonal antibody inhibition of enzyme activity of phenobarbital-induced cytochrome P-450.
Topics: Animals; Antibodies, Monoclonal; Benzphetamine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Effect of warfarin on plasma concentrations of vitamin K dependent coagulation factors in patients with stable control and monitored compliance.
Topics: Aged; Blood Coagulation Factors; Factor IX; Factor VII; Factor X; Female; Humans; Male; Middle Aged; Patient Compliance; Phenobarbital; Prothrombin; Warfarin | 1990 |
Hepatic microsomal warfarin metabolism in warfarin-resistant and susceptible mouse strains: influence of pretreatment with cytochrome P-450 inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Female; Male; Mice; Microsomes, Liver; Phenobarbital; Sex Factors; Species Specificity; Stereoisomerism; Warfarin | 1990 |
Using the scoparone O-demethylase assay for categorizing types of hepatic microsomal monooxygenase inducers.
Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1989 |
Brief maternal deprivation of rats reduces hepatic mixed function oxidase activities.
Topics: Aminopyrine; Animals; Benzphetamine; Biotransformation; Body Weight; Coumarins; Enzyme Induction; Female; Handling, Psychological; Male; Maternal Deprivation; Microsomes, Liver; Mixed Function Oxygenases; Oxazines; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone.
Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Rifampin; Warfarin | 1989 |
7-ethenyloxycoumarin as a new substrate for fluorophotometric assay of hepatic microsomal epoxidizing activities.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spectrophotometry; Umbelliferones | 1989 |
Apparent warfarin resistance due to poor compliance.
Topics: Aged; Drug Resistance; Female; Humans; Male; Middle Aged; Patient Compliance; Phenobarbital; Warfarin | 1989 |
The combinations of inducers of the coumarin hydroxylase-locus help investigate their mode of action.
Topics: Amitrole; Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Induction; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Phenobarbital; Pyrazines; Pyrazoles | 1989 |
Poor compliance is a major factor in unstable outpatient control of anticoagulant therapy.
Topics: Ambulatory Care; Female; Humans; Male; Middle Aged; Patient Compliance; Phenobarbital; Warfarin | 1989 |
The 14CO2 breath test: facilities and limitations of a rapid and noninvasive method for in vivo evaluation of modified hepatic cytochrome P-450--a critique.
Topics: Animals; Breath Tests; Carbon Dioxide; Cytochrome P-450 Enzyme System; Female; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Warfarin | 1987 |
Low-dose phenobarbitone as an indicator of compliance with drug therapy.
Topics: Adult; Aged; Antihypertensive Agents; Female; Humans; Hypertension; Male; Middle Aged; Patient Compliance; Phenobarbital; Valproic Acid; Warfarin | 1987 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin.
Topics: Animals; Autoanalysis; Coumarins; Cytochrome P-450 Enzyme System; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitriles; Phenobarbital; Rats; Rats, Inbred F344 | 1988 |
[Isolation and characteristics of coumarin-specific cytochrome P-450 (P-450Cho) from liver microsomes of DBA/2N mice, induced with pyrazole].
Topics: Animals; Coumarins; Cytochromes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Hydroxylation; Mice; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Pyrazoles; Solubility; Spectrophotometry, Ultraviolet; Substrate Specificity | 1988 |
Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level.
Topics: Age Factors; Aging; Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine; Hepatectomy; Liver; Liver Regeneration; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
A new monooxygenase product from 7-ethoxycoumarin and its relation to the O-dealkylation reaction.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Coumarins; Cytochrome b Group; Cytochromes b5; Enzyme Induction; Hydroxylation; Isoenzymes; Mice; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Oxygenases; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Substrate Specificity; Swine; Time Factors | 1985 |
Induction of drug metabolizing enzymes in human liver cell line Hep G2.
Topics: Cell Line; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Humans; Isoenzymes; Liver; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Sulfurtransferases | 1985 |
Induction of liver cytochrome P-450 in mice by warfarin. Comparison of warfarin-, phenobarbitone-, and cobalt-induced hepatic microsomal protein patterns by PAGE after partial purification on octyl-sepharose CL-4B.
Topics: Animals; Chromatography, Agarose; Cobalt; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Proteins; Warfarin | 1985 |
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin | 1985 |
The influence of triiodothyronine (T3) and inducers on hepatic drug metabolism in rats of different ages.
Topics: Age Factors; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Ethylmorphine; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Triiodothyronine | 1985 |
Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Oxazines; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences.
Topics: Acetaminophen; Barbiturates; Chlorothiazide; Chlorpropamide; Dicumarol; Humans; Methods; Nicotinic Acids; Oxyphenbutazone; Phenacetin; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Salicylates; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Sulfinpyrazone; Sulfisoxazole; Theobromine; Theophylline; Warfarin | 1973 |
In vitro induction of drug monooxygenase activity by phenobarbital in the isolated mouse jejunum.
Topics: Animals; Carbon Isotopes; Coumarins; Dactinomycin; Dealkylation; Enzyme Induction; In Vitro Techniques; Intestinal Mucosa; Jejunum; Leucine; Male; Mice; Oxygenases; Phenobarbital; Protein Binding; Protein Biosynthesis; Puromycin | 1973 |
Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.
Topics: Animals; Carbon Monoxide; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Activation; Enzyme Induction; Female; Fluorescence; Indophenol; Jejunum; Light; Liver; Mice; Microsomes; Monoamine Oxidase; NADP; Oxidoreductases; Phenobarbital; Stimulation, Chemical | 1973 |
In vitro induction by phenobarbital of drug monooxygenase activity in mouse isolated small intestine.
Topics: Animals; Carbon Radioisotopes; Coumarins; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dactinomycin; Dealkylation; Enzyme Induction; Fluorometry; Hydrogen-Ion Concentration; Intestinal Mucosa; Jejunum; Leucine; Male; Mice; Microsomes; NADP; Oxygenases; Perfusion; Phenobarbital; Puromycin; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
A direct test for mono-oxygenase activity of intact small intestine using surface reflectance fluorimetry.
Topics: Animals; Coumarins; Dealkylation; Fluorometry; Glucose; Hypotonic Solutions; In Vitro Techniques; Intestine, Small; Kinetics; Male; Mice; Mice, Inbred C57BL; NADP; Oxygenases; Phenobarbital; Time Factors | 1974 |
Further studies on genetically mediated differences in monooxygenase activities and spin state of cytochrome P450 iron from rabbit, rat, and mouse liver.
Topics: Animals; Anisoles; Cholic Acids; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Flavonoids; Genetics; Hydrocarbons; Mice; Microsomes, Liver; Mixed Function Oxygenases; Naphthols; Oxidoreductases; Oxidoreductases, N-Demethylating; p-Dimethylaminoazobenzene; Phenobarbital; Rabbits; Rats; Sodium; Species Specificity | 1973 |
Intensive monitoring for adverse drug effects in patients discharged from acute medical wards.
Topics: Adolescent; Adult; Age Factors; Aged; Drug Interactions; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Edema; Ethnicity; Female; Glyburide; Glycyrrhiza; Hematologic Diseases; Hospitalization; Humans; Male; Middle Aged; New Zealand; Outpatient Clinics, Hospital; Phenobarbital; Plants, Medicinal; Purpura, Thrombocytopenic; Quinidine; Sex Factors; Succinates; Triterpenes; Warfarin | 1973 |
Enhancement of microsomal drug hydroxylation and glucuronidation in rat liver by phenobarbital and 3-methylcholanthrene in combination.
Topics: Animals; Anisoles; Benzopyrenes; Cetylpyridinium; Coumarins; Culture Media; Digitonin; Drug Synergism; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Oxygenases; Phenobarbital; Rats; Stimulation, Chemical; Trypsin | 1974 |
A comparative study on drug hydroxylation and glucuronidation in liver microsomes of phenobarbital and 3-methylcholanthrene treated rats.
Topics: Animals; Anisoles; Cetylpyridinium; Coumarins; Cytochrome P-450 Enzyme System; Digitonin; Drug Combinations; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Oxidoreductases; Phenobarbital; Phospholipases; Proteins; Stimulation, Chemical; Thiocyanates; Trypsin | 1974 |
Observations of uridine diphosphate glucuronyltransferase activity towards oestriol and xenobiotics in developing and cultured tissues from mouse and man.
Topics: Aniline Compounds; Animals; Bilirubin; Biological Assay; Chick Embryo; Coumarins; Culture Techniques; Estriol; Female; Fetus; Glucuronosyltransferase; Hexosyltransferases; Humans; Kidney; Liver; Male; Mice; Microsomes, Liver; Phenobarbital; Phenols; Pregnancy; Sonication; Time Factors | 1973 |
Effect of drugs on hepatic drug metabolism in the fetus and newborn.
Topics: Animals; Animals, Newborn; Coumarins; Female; Fetus; Glucose-6-Phosphatase; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sleep; Transferases | 1970 |
Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat.
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Coumarins; Drug Antagonism; Enzymes; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Phosphoric Monoester Hydrolases; Rats; Toluene | 1970 |
Relation between drug-metabolizing activity and phospholipids in hepatic microsomes. I. Effects of phenobarbital, carbon tetrachloride, and actinomycin D.
Topics: Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucose-6-Phosphatase; Lysophosphatidylcholines; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phosphatidylethanolamines; Phospholipids; Proteins; Rats; Stimulation, Chemical | 1972 |
Effects of drugs or hepatotoxins on the relation between drug-metabolizing activity and phospholipids in hepatic microsomes during choline deficiency.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Diet; Female; Germ-Free Life; Glucose-6-Phosphatase; Guanine Nucleotides; Inosine; Lysophosphatidylcholines; Male; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphoric Monoester Hydrolases; Proteins; Rats; Time Factors | 1973 |
Inhibition and enhancement of mammary tumorigenesis by 7,12-dimethylbenz (a) anthracene in the female sprague-dawley rat.
Topics: Animals; Benz(a)Anthracenes; Coumarins; Enzyme Induction; Female; Glucose-6-Phosphatase; Liver; Mammary Neoplasms, Experimental; Phenobarbital; Rats | 1974 |
Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).
Topics: Animals; Coumarins; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Female; Genetic Variation; Hybridization, Genetic; Kidney; Liver; Lung; Male; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Mixed Function Oxygenases; Phenobarbital | 1974 |
The interaction of a fluorescent probe with rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Oxidoreductases; Phenobarbital; Rats; Sulfites; Sulfonic Acids; Warfarin | 1970 |
Comparison of the O-dealkylation of 7-ethoxycoumarin and the hydroxylation of benzo(a)pyrene in human placenta. Effect of cigarette smoking.
Topics: Animals; Benzopyrenes; Coumarins; Dealkylation; Enzyme Induction; Ethyl Ethers; Female; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Placenta; Pregnancy; Rats; Smoking; Time Factors | 1974 |
[Pharmacokinetics of phenprocoumon (Marcumar) in patients with liver cirrhosis and following induction treatment with phenobarbital].
Topics: Benzyl Compounds; Coumarins; Drug Synergism; Enzyme Induction; Humans; Liver Cirrhosis; Phenobarbital; Protein Binding | 1974 |
The influence of methyl groups on toxicity and drug metabolism.
Topics: Administration, Oral; Amphetamine; Animals; Carbon Isotopes; Coumarins; Enzyme Induction; Female; Humans; Mephobarbital; Methylation; Microscopy, Electron; Microsomes, Liver; Nicotine; Phenobarbital; Phenols; Phospholipids; Pyrazoles; Rats; Structure-Activity Relationship; Tritium | 1973 |
Warfarin metabolites: the anticoagulant activity and pharmacology of warfarin alcohols.
Topics: Alcohols; Anticoagulants; Blood Coagulation Factors; Chromatography, Thin Layer; Humans; Isomerism; Phenobarbital; Prothrombin Time; Spectrum Analysis; Structure-Activity Relationship; Vitamin K; Warfarin | 1973 |
Dose-dependent enzyme induction.
Topics: Amobarbital; Animals; Antipyrine; Dose-Response Relationship, Drug; Enzyme Induction; Half-Life; Humans; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Secobarbital; Sleep; Warfarin | 1973 |
Effect of underfeeding suckling rats on the activity of hepatic drug metabolizing enzymes.
Topics: Animals; Animals, Newborn; Benzoates; Biphenyl Compounds; Body Weight; Coumarins; Cytochrome P-450 Enzyme System; DNA; Female; Glucuronates; Hexosyltransferases; Liver; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nutrition Disorders; Organ Size; Oxidoreductases; Phenobarbital; Pregnancy; Rats | 1973 |
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Determination of phenylbutazone in plasma.
Topics: Animals; Injections, Intravenous; Male; Methods; Oxidation-Reduction; Phenobarbital; Phenylbutazone; Phenytoin; Potassium Permanganate; Rats; Salicylates; Spectrophotometry; Spectrum Analysis; Sulfadiazine; Time Factors; Ultraviolet Rays; Warfarin | 1972 |
The O-dealkylation of 7-ethoxycoumarin by liver microsomes. A direct fluorometric test.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Fluorometry; Kinetics; Mice; Microsomes, Liver; Oxygenases; Phenobarbital | 1972 |
Non-equivalent preparations of the same drug.
Topics: Chloramphenicol; Dosage Forms; Humans; Nitrofurantoin; Oxytetracycline; Pharmaceutical Preparations; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Tetracycline; Therapeutic Equivalency; Tolbutamide; Warfarin | 1971 |
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1971 |
Variable effect of phenobarbital treatment of mice on hepatic UDP-glucuronyltransferase activity when judged by slightly different enzyme-assay techniques.
Topics: Animals; Coumarins; Female; Glucuronates; In Vitro Techniques; Liver; Male; Mice; Nitrophenols; Phenobarbital; Phenolphthaleins; Phenols; Stimulation, Chemical; Surface-Active Agents; Transferases; Uracil Nucleotides | 1971 |
Interactions between digitoxin and other drugs in vitro and in vivo.
Topics: Binding Sites; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Clofibrate; Digitoxin; Digoxin; Drug Antagonism; Enzyme Induction; Erythrocytes; Humans; Microsomes, Liver; Phenobarbital; Phenylbutazone; Phenytoin; Protein Binding; Radioisotopes; Rubidium; Serum Albumin; Sulfadimethoxine; Tolbutamide; Tritium; Warfarin | 1971 |
Clinical implications of enzyme induction.
Topics: Alcohols; Amobarbital; Animals; Antipyrine; Benzazepines; Blood Coagulation; Chloral Hydrate; Chlordiazepoxide; Enzyme Induction; Ethanol; Fluorometry; Half-Life; Humans; Hydrocortisone; Hypnotics and Sedatives; Ketones; Kinetics; Male; Metabolism; Microsomes, Liver; Morphinans; Nitro Compounds; Paralysis; Phenobarbital; Rats; Rheumatic Heart Disease; Secobarbital; Sleep; Time Factors; Warfarin | 1971 |
Multiplicity and specificity of UDP-glucuronyl transferase. II. Influence of phenobarbital and cholestasis on the activity of glucuronyl transferase and beta-glucuronidase in rat liver.
Topics: Animals; Bilirubin; Cholestasis; Coumarins; Female; Glucuronates; Glucuronidase; Liver; Male; Nitrophenols; Nucleoside Diphosphate Sugars; Phenobarbital; Rats; Spectrophotometry; Stimulation, Chemical; Transferases; Uracil Nucleotides | 1970 |
Effect of coumarin, BHT and phenobarbitone on protein synthesis in the rat liver.
Topics: Amino Acids; Animals; Antioxidants; Centrifugation, Density Gradient; Coumarins; Cresols; Endoplasmic Reticulum; Female; Liver; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; RNA | 1969 |
Drugs and the liver.
Topics: Bilirubin; Cushing Syndrome; DDT; Enzyme Induction; Ethanol; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice, Neonatal; Liver; Male; Phenobarbital; Phenytoin; Porphyrins; Pregnancy; Transferases; Warfarin | 1970 |
The effect of drugs on clinical laboratory determinations.
Topics: 17-Ketosteroids; Chemistry, Clinical; Drug Antagonism; Drug Synergism; Drug Therapy; Hemorrhage; Humans; Nalidixic Acid; Pharmaceutical Preparations; Phenobarbital; Phenylbutazone; Steroids; Tolbutamide; Urine; Warfarin | 1971 |
[On the question of inducibility of microsomal enzymes for the example of coumarin hydroxylation in the rabbit liver].
Topics: Animals; Animals, Newborn; Benzopyrenes; Coumarins; Cytochromes; Enzyme Induction; Liver; Microsomes; Mixed Function Oxygenases; Organ Size; Phenobarbital; Rabbits; Stimulation, Chemical | 1968 |
[Spectral changes of rabbit liver microsomes caused by coumarin].
Topics: Animals; Coumarins; Cytochromes; Kinetics; Liver; Male; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rabbits; Spectrophotometry | 1968 |
Stimulatory effect of phenobarbital and insecticides on warfarin metabolism in the rat.
Topics: Animals; Carbon Isotopes; Chlordan; Chromatography, Thin Layer; DDT; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Stimulation, Chemical; Warfarin | 1968 |
Effect of coumarin and other compounds on ribosomal protein synthesis in the rat liver.
Topics: Amino Acids; Animals; Coumarins; Cresols; Dactinomycin; Depression, Chemical; Female; Liver; Male; Oils; Phenobarbital; Polynucleotides; Protein Biosynthesis; Rats; Ribosomes; RNA, Messenger; Stimulation, Chemical; Uracil Nucleotides; Zea mays | 1968 |
Clinical observations of possible barbiturate interference with anticoagulation.
Topics: Adolescent; Adult; Aged; Anticoagulants; Barbiturates; Coumarins; Enzyme Induction; Female; Hemorrhage; Humans; Hypoprothrombinemias; Male; Middle Aged; Myocardial Infarction; Phenobarbital; Prothrombin Time; Warfarin | 1968 |
Properties of 3-(1-phenyl-propyl)-4-oxycoumarin (marcoumar) in the plasma when tested in normal cases and under the influence of drugs.
Topics: Blood Proteins; Coumarins; Drug Synergism; Ethyl Biscoumacetate; Fluorometry; Phenobarbital; Phenylbutazone; Protein Binding; Spectrophotometry; Sulfadimethoxine; Sulfinpyrazone; Tolbutamide | 1968 |
Origin of delayed development of drug metabolism in the newborn rat.
Topics: Animals; Animals, Newborn; Coumarins; Female; Methylcholanthrene; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sleep; Time Factors | 1969 |
The interaction between cholestyramine and drugs.
Topics: Adsorption; Animals; Aspirin; Bile Acids and Salts; Blood; Chlorothiazide; Cholestyramine Resin; Dogs; Intestinal Absorption; Nicotinic Acids; Phenobarbital; Phenylbutazone; Quinidine; Rats; Spectrophotometry; Tetracycline; Urine; Warfarin | 1965 |
Enzyme induction: phenobarbital and the coumarins.
Topics: Blood Coagulation Disorders; Coumarins; Drug Incompatibility; Humans; Phenobarbital | 1966 |
Hemorrhage while on anticoagulant therapy precipitated by drug interaction.
Topics: Aged; Coumarins; Diazepam; Drug Synergism; Female; Glutethimide; Hemorrhage; Humans; Male; Middle Aged; Oxyphenbutazone; Phenobarbital; Vitamin K 1 | 1967 |
Serum protein binding of diazepam, desmethyldiazepam, furosemide, indomethacin, warfarin, and phenobarbital in human fetus, mother, and newborn infant.
Topics: Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Fetal Blood; Furosemide; Humans; Indomethacin; Infant, Newborn; Maternal-Fetal Exchange; Nordazepam; Phenobarbital; Pregnancy; Protein Binding; Warfarin | 1983 |
Purification and characterization of cytochrome P-450 with high affinity for 7-alkoxycoumarins.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Coumarins; Cytochrome P-450 Enzyme System; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Protein Binding; Rats; Substrate Specificity | 1984 |
Influence of cytochrome P-450 type on the pattern of conjugation of 7-hydroxycoumarin generated from 7-alkoxycoumarins.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Ethanol; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Umbelliferones | 1984 |
Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzene Derivatives; Chloramphenicol; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Iodobenzoates; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH Oxidases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats.
Topics: 4-Hydroxycoumarins; Animals; Dose-Response Relationship, Drug; Half-Life; Intestine, Small; Liver; Male; Phenobarbital; Proadifen; Prothrombin; Rats; Rats, Inbred Strains; Tissue Distribution; Warfarin | 1983 |
Dynamics of xenobiotic metabolism by isolated rat hepatocytes using a multichannel perifusion system.
Topics: Aldrin; Animals; Biochemistry; Biotransformation; Coumarins; Equipment Design; In Vitro Techniques; Liver; Male; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450).
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Catalysis; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunochemistry; Immunoelectrophoresis; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1984 |
Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line P815) cells.
Topics: Animals; Biotransformation; Cell Survival; Cells, Cultured; Coumarins; Cyclophosphamide; Hydrazines; Liver; Male; Mast-Cell Sarcoma; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sarcoma, Experimental | 1982 |
Evidence against an abstraction or direct insertion mechanism for cytochrome P-450 catalysed meta hydroxylations.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Deuterium; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Warfarin | 1982 |
Comparative pharmacokinetics of coumarin anticoagulants. XLVI: Effect of treatment of phenobarbital on pharmacokinetics of (S)-(-)-warfarin in rats.
Topics: Animals; Blood Coagulation; Blood Proteins; Enzyme Induction; Male; Metabolic Clearance Rate; Phenobarbital; Protein Binding; Rats; Warfarin | 1980 |
Changes in the metabolic profiles of R- and S-warfarin and R- and S-phenprocoumon as a probe to categorize the effect of inducing agents on microsomal hydroxylases.
Topics: 4-Hydroxycoumarins; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenprocoumon; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Stereoisomerism; Warfarin | 1981 |
Procoagulant effect of phenobarbital in rats.
Topics: Animals; Blood Coagulation; Blood Coagulation Factors; Male; Phenobarbital; Prothrombin; Prothrombin Time; Rats; Time Factors; Warfarin | 1980 |
Influence of aging and induction of rat liver and kidney microsomal mixed function oxidase systems.
Topics: Aging; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; In Vitro Techniques; Kidney; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Warfarin | 1980 |
Effects of induction on R- and S-warfarin and metabolite concentrations in rat plasma.
Topics: Animals; Blood Coagulation; Enzyme Induction; Half-Life; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Stereoisomerism; Warfarin | 1980 |
Induction of liver microsomal cytochrome P450 in cynomolgus monkeys.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Caffeine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochromes b5; Dexamethasone; Enzyme Induction; Female; Hydroxylation; Isoenzymes; Macaca fascicularis; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxazines; Oxidation-Reduction; Phenobarbital; Sex Factors; Species Specificity; Testosterone | 1995 |
[Biotransformation processes in fertile hen's eggs. 1. Metabolic transformation of 7-ethoxycoumarin].
Topics: Animals; Biotransformation; Chick Embryo; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronates; Methylcholanthrene; Ovalbumin; Phenobarbital; Sulfates | 1995 |
Effect of immobilization on the activity of rat hepatic microsomal cytochrome P450 enzymes.
Topics: Animals; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzymes, Immobilized; Male; Membranes, Artificial; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Rats, Wistar; Umbelliferones | 1993 |
Induction of cytochrome P-450 isoenzymes in cultured monkey hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Liver; Male; Oxidoreductases, O-Demethylating; Phenobarbital; Rifampin; Saimiri; Steroid Hydroxylases | 1995 |
Metabolism of nitrosamines and aflatoxin B1 by hamster liver CYP2A enzymes.
Topics: Aflatoxin B1; Animals; Blotting, Western; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Kinetics; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Pyrazoles; Steroid Hydroxylases | 1994 |
Scoparone O-demethylase assay is not useful to differentiate the effects of model inducers of cytochrome P-450 in rabbit and guinea pig liver.
Topics: Animals; Biomarkers; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Humans; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, O-Demethylating; Phenobarbital; Rabbits; Rats; Rats, Wistar; Species Specificity | 1993 |
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Cloning, sequencing, and functional studies of phenobarbital-inducible forms of cytochrome P450 2B and 4B expressed in rabbit kidney.
Topics: Amino Acid Sequence; Androstenedione; Animals; Base Sequence; Cloning, Molecular; Coumarins; Cytochrome P-450 Enzyme System; DNA Probes; Enzyme Induction; Kidney; Molecular Sequence Data; Phenobarbital; Rabbits; Recombinant Proteins; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Species Specificity; Steroid Hydroxylases; Tissue Distribution | 1993 |
Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver.
Topics: Animals; Antihypertensive Agents; Benzoflavones; beta-Naphthoflavone; Biotransformation; Clofibrate; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Species Specificity | 1993 |
Substrate influence on interaction between cytochrome P450 and cytochrome b5 in microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Coumarins; Cross-Linking Reagents; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes b5; Ethyldimethylaminopropyl Carbodiimide; In Vitro Techniques; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rabbits; Steroid Hydroxylases; Substrate Specificity | 1996 |
Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins.
Topics: Animals; Anticoagulants; Anticonvulsants; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A1; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Furocoumarins; Heme; Humans; Hypnotics and Sedatives; Methylcholanthrene; Mice; Mice, Inbred SENCAR; Microsomes, Liver; Phenobarbital; Plant Extracts; Radioligand Assay | 1996 |
7-Ethoxy-3,4-dimethylcoumarin: a substrate for a cytochrome P450-mediated mono-oxygenase activity that is highly induced by phenobarbitone and beta-naphthoflavone.
Topics: Animals; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Perfusion; Phenobarbital; Rats; Rats, Wistar | 1996 |
7-ethoxycoumarin deethylation activity in perfused isolated rat brain.
Topics: Animals; beta-Naphthoflavone; Brain; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Perfusion; Phenobarbital; Rats; Rats, Wistar | 1999 |
Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.
Topics: Animals; beta-Naphthoflavone; Cell Separation; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.
Topics: 4-Butyrolactone; Aflatoxin B1; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalytic Domain; Coumarins; Diet; Ellagic Acid; Enzyme Induction; Ethoxyquin; Glutamate-Cysteine Ligase; Glutathione; Inactivation, Metabolic; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Wistar | 2000 |
CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes.
Topics: Animals; beta-Naphthoflavone; Clofenapate; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Glucocorticoids; Glucuronic Acid; Isoenzymes; Isoniazid; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substrate Specificity; Sulfates | 2000 |
Subarachnoid haemorrhage treated with anticoagulants.
Topics: Adult; Anticoagulants; Female; Humans; Magnetic Resonance Imaging; Phenobarbital; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Warfarin | 2000 |
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Coumarins; Cyclophosphamide; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Microsomes, Liver; Phenobarbital; Rats; Toxicity Tests; Trichloroethylene; Xenopus laevis | 2001 |
Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Fluorescent Dyes; Isoenzymes; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Quinolines; Rats; Rats, Sprague-Dawley; Substrate Specificity | 2001 |
Liver slice technology as an in vitro model for metabolic and toxicity studies.
Topics: Animals; Cell Survival; Cells, Cultured; Coumarins; Dissection; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Models, Biological; Perfusion; Phenobarbital; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase | 2002 |
PENTAERYTHRITOL TETRANITRATE, AS ADJUNCT THERAPY IN THE IMMEDIATE POSTINFARCTION PERIOD.
Topics: Biomedical Research; Blood Pressure; Blood Pressure Determination; Drug Therapy; Heart Rate; Heparin; Humans; Meperidine; Myocardial Infarction; Pentaerythritol Tetranitrate; Pharmacology; Phenobarbital; Placebos; Pulse; Warfarin | 1964 |
Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adolescent; Adult; Aged; Animals; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Middle Aged; Molecular Probes; Molecular Structure; Phenobarbital; Rats; Rats, Wistar; Selegiline; Substrate Specificity | 2004 |
Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Constitutive Androstane Receptor; Coumarins; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Liver; Male; Orchiectomy; Oximes; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sex Factors; Steroid Hydroxylases; Swine; Swine, Miniature; Thiazoles; Transcription Factors | 2006 |
Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography.
Topics: Animals; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Flow Injection Analysis; Liver; Microsomes, Liver; Oxazines; Phenobarbital; Rats; Reproducibility of Results; Substrate Specificity; Time Factors | 2007 |
Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.
Topics: Aging; Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Enzyme Inhibitors; Hydroxylation; Liver; Male; Mixed Function Oxygenases; Organ Culture Techniques; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Testosterone; Time Factors | 2008 |
Tablet splitting and weight uniformity of half-tablets of 4 medications in pharmacy practice.
Topics: Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Anticoagulants; Cost Savings; Digoxin; Dose-Response Relationship, Drug; Drug Compounding; Humans; Hypnotics and Sedatives; Jordan; Pharmaceutical Preparations; Phenobarbital; Prednisolone; Quality Control; Reproducibility of Results; Tablets; Warfarin | 2012 |
Biotransformation of columbianadin by rat hepatic microsomes and inhibition of biotransformation products on NO production in RAW 264.7 cells in vitro.
Topics: Angelica; Animals; Anti-Inflammatory Agents; Biotransformation; Cell Line; Coumarins; Furocoumarins; Lipopolysaccharides; Macrophages; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes, Liver; Nitric Oxide; Phenobarbital; Plant Roots; Rats; Rats, Sprague-Dawley | 2012 |
Induction of cytochrome P450 enzymes in primary equine hepatocyte culture.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antitubercular; Cell Survival; Cells, Cultured; Coumarins; Culture Media, Serum-Free; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Enzyme Induction; Hepatocytes; Horses; Hypnotics and Sedatives; Immunohistochemistry; Indicators and Reagents; Kinetics; Phenobarbital; Rifampin; Veterinary Drugs | 2013 |
An analytical strategy for the identification of carbamates, toxic alkaloids, phenobarbital and warfarin in stomach contents from suspected poisoned animals by thin-layer chromatography/ultraviolet detection.
Topics: Alkaloids; Animals; Carbamates; Cat Diseases; Cats; Chromatography, Thin Layer; Dog Diseases; Dogs; Gastrointestinal Contents; Phenobarbital; Poisoning; Warfarin | 2019 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Mice; Phenobarbital; Seizures; Valproic Acid | 2023 |