phenobarbital has been researched along with spironolactone in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (80.82) | 18.7374 |
| 1990's | 2 (2.74) | 18.2507 |
| 2000's | 8 (10.96) | 29.6817 |
| 2010's | 4 (5.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Choudhuri, S; Guo, GL; Klaassen, CD | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Selye, H; Taché, J; Taché, Y | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Eaton, DL; Iga, T; Klaassen, CD | 1 |
| Da Silva, OM; Kourounakis, P; Lykissas, ED | 1 |
| Mottino, AD; Rassero, JA; Rodriguez Garay, EA | 1 |
| Hepner, GW; Piken, E | 1 |
| Garg, BD; Kourounakis, P; Tuchweber, B | 1 |
| Bjondahl, K | 1 |
| Challiner, MR; Park, BK; Whittaker, AD | 1 |
| Schmoldt, A | 1 |
| Kourounakis, P; Ship, S | 1 |
| Loginov, AS | 1 |
| Salas, M; Tuchweber, B | 1 |
| Klaassen, CD | 4 |
| Alakare, B; Kärki, NT; Nevasaari, K | 2 |
| Paumgartner, G; Schwarz, HP; von Bergmann, K | 2 |
| Guibert, EE; Mottino, AD; Rodríguez Garay, EA | 1 |
| Gouma, C; Kourounakis, P; Rekka, E | 1 |
| Conney, AH; Kovacs, K; Kuntzman, R; Solymoss, B; Somogyi, A | 1 |
| Davis, DC; Gillette, JR; Sasame, HA | 1 |
| Mécs, I; Selye, H; Szabo, S | 2 |
| Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 2 |
| Kourounakis, P; Selye, H; Szabo, S | 2 |
| Solymoss, B; Zsigmond, G | 3 |
| Basu, P; Feller, DR; Kramer, PF | 1 |
| Bitto, T; Chiesa, G; Del Ninno, E; Ideo, G; Mirabile, V; Portaleone, D; Tornaghi, GC | 1 |
| Selye, H; Szabo, S; Taché, Y | 1 |
| Gillette, JR; Stripp, B | 1 |
| Gillette, JR | 1 |
| Selye, H | 1 |
| Solymoss, B; Toth, S; Varga, S; Werringloer, J; Zsigmond, G | 1 |
| Rawlins, MD; Smith, SE; Taylor, SA | 1 |
| Colombo, M; Del Ninno, E; Tornaghi, G; Tripodi, A | 1 |
| Csongor, J; Szilágyi, T; Tóth, S | 1 |
| Fish, CA; Haddow, JE; Lester, R; Marshall, PC | 1 |
| Stohs, SJ; Talcott, RE | 1 |
| Beaulieu, T; Jago, MV; Kovacs, K; Tuchweber, B | 1 |
| Hänninen, O; Marselos, M | 1 |
| Bjondahl, K; Isomaa, B; Nieminen, L | 1 |
| Castle, MC; Lage, GL | 1 |
| Selye, H; Szabo, S | 1 |
| Blascheck, JA; Garg, BD; Kovacs, K | 1 |
| Kovacs, K; Tuchweber, B | 1 |
| Elias, AN; Gwinup, G | 1 |
| Dobbs, BR; Faed, EM; Lee, D | 1 |
| Bellward, GD; Gontovnick, LS; Sunahara, G | 1 |
| Nokubo, M; Tsuchiya, M | 1 |
| Ando, M; Ishii, K; Kamataki, T; Kato, R; Yamazoe, Y | 1 |
| Chan, JC; Cooper, SM | 1 |
| Kourounakis, PN; Tani, E | 1 |
| Gachályi, B; Renczes, G; Szabó, I | 1 |
| Inoue, Y; Kurata, Y; Makinodan, F; Tanaka, K; Wako, Y | 1 |
| Borowicz, KK; Czuczwar, SJ | 1 |
5 review(s) available for phenobarbital and spironolactone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Cytochrome P-450 and its role in drug metabolism.
Topics: Adrenalectomy; Animals; Carbon Tetrachloride; Cytochromes; Dealkylation; Deamination; Enzyme Induction; Female; Glucocorticoids; Hydroxylation; Male; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Polycyclic Compounds; Pseudomonas; Rats; Sex Factors; Spectrum Analysis; Spironolactone; Ultraviolet Rays | 1972 |
Effects of steroids upon the liver ultrastructure.
Topics: Animals; Benzopyrenes; Desoxycorticosterone; Endocrine Glands; Enzyme Induction; Glucocorticoids; Glycogen; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Norpregnenes; Phenobarbital; Pregnenolone Carbonitrile; Protein Biosynthesis; RNA; Spironolactone; Steroids | 1973 |
Protection by catatoxic steroids against cyclophosphamide-induced organ lesions.
Topics: Adrenal Glands; Animals; Body Weight; Bone Marrow; Cyclophosphamide; Desoxycorticosterone; Enzyme Induction; Estradiol; Ethylestrenol; Female; Ketones; Microsomes, Liver; Mortality; Oxandrolone; Phenobarbital; Prednisolone; Pregnancy; Pregnanediones; Pregnanes; Pregnenolone; Progesterone; Rats; Spironolactone; Thyroxine; Triamcinolone | 1970 |
Effects of some clinically encountered drugs on steroid synthesis and degradation.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Drug Interactions; Ethanol; Fetus; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hydroxycholecalciferols; Liver; Metyrapone; Mitotane; Phenobarbital; Phenytoin; Rifampin; Spironolactone; Steroids | 1980 |
68 other study(ies) available for phenobarbital and spironolactone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
Topics: Animals; Blotting, Northern; DNA Probes; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ligands; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membranes; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2002 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Inhibition of the effects of alfathesin and other steroid anesthetics by catatoxic steroids in rats.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Female; Ketosteroids; Phenobarbital; Phenytoin; Prednisolone; Pregnanediones; Pregnanes; Pregnenes; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Thyroxine; Time Factors | 1975 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Uptake of unconjugated bilirubin by isolated rat hepatocytes.
Topics: Animals; Bilirubin; Biological Transport; Choline; Diethylstilbestrol; Kinetics; Lithium; Liver; Male; Ouabain; Phenobarbital; Rats; Spironolactone; Sulfobromophthalein; Taurocholic Acid | 1979 |
Alterations in the hepatic subcellular composition of nucleic acids and proteins in rats treated with pregnenolone-16alpha-carbonitrile, spironolactone or phenobarbital.
Topics: Animals; Cell Nucleus; DNA; Female; Liver; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; RNA; Spironolactone | 1979 |
Effect of spironolactone on bilirubin conjugation by the rat liver.
Topics: Animals; Bilirubin; Liver; Organ Size; Phenobarbital; Proteins; Rats; Spironolactone; Time Factors | 1979 |
Decreased hepatic microsomal reserve in patients with cirrhosis. Studies using aminopyrine as model drug.
Topics: Adult; Aminopyrine; Antipyrine; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Microsomes, Liver; Middle Aged; Phenobarbital; Spironolactone | 1979 |
Fine structural changes in the liver of young and old rats as influenced by microsomal enzyme inducers.
Topics: Aging; Animals; Dexamethasone; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1979 |
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver Injury; Female; Nafenopin; Phenobarbital; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Time Factors; Triglycerides | 1978 |
The effect of enzyme induction on the irreversible binding of ethynyloestradiol to guinea pig liver microsomes.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Ethinyl Estradiol; Flavonoids; Guinea Pigs; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rifampin; Spironolactone | 1978 |
Increased digitoxin cleavage by liver microsomes of spironolactone-pretreated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Digitoxin; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Spironolactone; Time Factors | 1978 |
Influence of combined treatment with pregnenolone-16alpha-carbonitrile and spironolactone or phenobarbital on drug metabolism in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Microsomes, Liver; Nitriles; Phenobarbital; Pregnenolone; Rats; Spironolactone; Zoxazolamine | 1977 |
[Treatment of chronic diseases of the liver].
Topics: Adrenal Cortex Hormones; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Phenobarbital; Spironolactone; Vitamin B 12 | 1977 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estradiol; Fatty Liver; Female; Golgi Apparatus; Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Triglycerides | 1976 |
Studies on the mechanism of spironolactone protection against indomethacin toxicity.
Topics: Animals; Bile; Depression, Chemical; Enzyme Induction; In Vitro Techniques; Indomethacin; Male; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors | 1976 |
Different effects of microsomal enzyme inducers on the biliary excretion of digoxin.
Topics: Animals; Benzopyrenes; Bile; Digoxin; Enzyme Induction; Liver; Male; Microsomes, Liver; Perfusion; Phenobarbital; Rats; Spironolactone | 1976 |
Biliary excretion of ouabain in isolated perfused rat liver after treatment with microsomal enzyme inducers.
Topics: Animals; Benzopyrenes; Bile; Enzyme Induction; Liver; Male; Microsomes, Liver; Ouabain; Perfusion; Phenobarbital; Rats; Spironolactone | 1976 |
Effect of microsomal enzyme inducers on the biliary excretion of an exogenous load of bilirubin in newborn rats.
Topics: Age Factors; Animals; Animals, Newborn; Bile; Bilirubin; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1976 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on bile formation in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Body Weight; Cholesterol; Liver; Male; Organ Size; Phenobarbital; Phospholipids; Pregnenolone Carbonitrile; Rats; Spironolactone; Taurocholic Acid | 1975 |
Additive effect of combined spironolactone and phenobarbital treatment on hepatic bilirubin UDP-glucuronyltransferase.
Topics: Animals; Body Weight; Drug Synergism; Enzyme Induction; Glucuronosyltransferase; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Spironolactone | 1989 |
In vivo interaction of spironolactone and phenobarbital with cholesterol; effect on cholesterol organ concentration.
Topics: Animals; Brain Chemistry; Cholesterol; Female; Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spironolactone | 1987 |
Suppression of 7,12-dimethylbenz( )anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylase.
Topics: Adrenal Gland Diseases; Androstanes; Animals; Benz(a)Anthracenes; Benzopyrenes; Betamethasone; Dexamethasone; Enzyme Induction; Ethylestrenol; Female; Fluorescence; Fluorine; Hydroxylation; Ketosteroids; Liver; Mixed Function Oxygenases; Necrosis; Phenobarbital; Polycyclic Compounds; Pregnenolone; Rats; Spironolactone | 1971 |
Protection by catatoxic steroids against the paralysis caused by combined treatment with thyroxine and methylphenidate.
Topics: Androstenols; Animals; Drug Synergism; Estradiol; Ethylestrenol; Female; Humans; Hydroxysteroids; Hyperkinesis; Ketosteroids; Methylphenidate; Norpregnanes; Paralysis; Phenobarbital; Phenytoin; Prednisolone; Pregnenolone Carbonitrile; Progesterone; Propionates; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Thyroxine | 1972 |
Effect of pharmacologic conditioning on sulfadiazine toxicity and concentrations in plasma.
Topics: Adrenocorticotropic Hormone; Androstenols; Animals; Depression, Chemical; Desoxycorticosterone; Estradiol; Female; Ketosteroids; Kidney; Organ Size; Phenobarbital; Prednisolone; Pregnanediones; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Stimulation, Chemical; Sulfadiazine; Thyroxine; Triamcinolone | 1974 |
Effect of microsomal enzyme inducers on the liver changes produced by common bile-duct ligature.
Topics: Animals; Bilirubin; Common Bile Duct; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Female; Glucuronosyltransferase; Hepatomegaly; Ligation; Liver; Liver Cirrhosis, Biliary; Microsomes, Liver; NADH, NADPH Oxidoreductases; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1974 |
Correlation (+)-amphetamine lethality and hepatic metabolism.
Topics: Animals; Dextroamphetamine; Enzyme Induction; In Vitro Techniques; Lethal Dose 50; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Spironolactone | 1974 |
[Proceedings: Effect of repeated administration of spironolactone, ethanol and phenobarbital on liver bilirubin UDPG-transferase in Gilbert's jaundice].
Topics: Adolescent; Adult; Bilirubin; Ethanol; Female; Glucuronosyltransferase; Hexosyltransferases; Humans; Hyperbilirubinemia, Hereditary; Liver; Male; Middle Aged; Phenobarbital; Spironolactone | 1973 |
Interruption of pregnancy by various steroids.
Topics: Abortion, Induced; Anabolic Agents; Animals; Cholesterol; Dehydroepiandrosterone; Dexamethasone; Digitoxin; Estradiol; Ethylestrenol; Female; Indomethacin; Oxandrolone; Phenobarbital; Prednisolone; Pregnancy; Pregnenolone; Progesterone; Rats; Spironolactone; Steroids; Triamcinolone | 1971 |
Proceedings: Increased cholesterol saturation in rat bile induced by spironolactone and pregnenolone-16alpha-carbonitrile.
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Male; Phenobarbital; Phospholipids; Pregnenolone Carbonitrile; Rats; Spironolactone | 1974 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Effect of spironolactone and ethylestrenol on benzo(a)pyrene hydroxylase (EC 1.14.1.1) and other chemical constituents of hepatic microsomes.
Topics: Animals; Benzopyrenes; Cytochromes; Ethylestrenol; Female; Fluorometry; Indophenol; Liver; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Phenols; Phospholipids; Proteins; Rats; Rats, Inbred Strains; Spectrophotometry; Spironolactone; Subcellular Fractions | 1971 |
Spironolactone--a weak enzyme inducer in man.
Topics: Adult; Antipyrine; Biotransformation; Drug Interactions; Enzyme Induction; Female; Half-Life; Humans; Liver; Male; Phenobarbital; Spironolactone | 1972 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine | 1974 |
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Enzyme Induction; Liver; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium | 1974 |
[The d-glucaric acid test in the evaluation of the inductive properties of phenobarbital and spironalactone].
Topics: Adipates; Adolescent; Adult; Bilirubin; Enzyme Induction; Female; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditary; Liver; Male; Phenobarbital; Spironolactone; Sugar Acids | 1974 |
Effect of spironolactone, pregnenolone-16 -carbonitrile and cortisol on the metabolism and biliary excretion of sulfobromophthalein and phenol-3,6-dibromophthalein disulfonate in rats.
Topics: Animals; Biliary Tract; Bromine; Female; Glutathione; Hydrocortisone; Kinetics; Liver; Nitriles; Organ Size; Phenobarbital; Phenolphthaleins; Pregnenolone; Rats; Rats, Inbred Strains; Spectrophotometry; Spironolactone; Sulfobromophthalein | 1972 |
Effect of spironolactone and phenobarbital on the plasma fibrinogen in rats.
Topics: Amino Acids; Animals; Carbon Isotopes; Female; Fibrinogen; Liver; Organ Size; Phenobarbital; Rats; Spironolactone; Time Factors | 1972 |
Biliary excretion of mercury enhanced by spironolactone.
Topics: Animals; Bile; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Kidney; Liver; Male; Mercury; Mercury Isotopes; Mercury Poisoning; Phenobarbital; Rats; Spironolactone | 1972 |
Protection by catatoxic steroids, phenobarbital and diphenylhydantoin against methaqualone intoxication.
Topics: Androstenes; Animals; Enzyme Induction; Ethylestrenol; Female; Hydroxysteroids; Ketosteroids; Methaqualone; Movement Disorders; Nitriles; Norsteroids; Oxandrolone; Phenobarbital; Phenytoin; Pregnenolone; Propionates; Rats; Spironolactone; Steroids | 1972 |
Effect of phenobarbital and spironolactone pretreatment on digitoxin-induced mortality in male and female rats.
Topics: Animals; Digitoxin; Drug Interactions; Female; Male; Phenobarbital; Rats; Spironolactone; Tritium | 1973 |
Effect of various steroids on the hepatic glucuronidation and biliary excretion of bilirubin.
Topics: Animals; Bile; Bile Pigments; Bilirubin; Body Weight; Female; Glucuronates; Hexosyltransferases; Hydrocortisone; Kinetics; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1973 |
Effect of steroidal and nonsteroidal microsomal enzyme inducers on the hepatotoxicity of pyrrolizidine alkaloids in rats.
Topics: Animals; Enzyme Induction; Ethylestrenol; Female; Hepatectomy; Kidney; Liver; Lung; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Pregnenolone Carbonitrile; Prodigiosin; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Spironolactone | 1974 |
Enhancement of D-glucuronolactone and acetaldehyde dehydrogenase activities in the rat liver by inducers of drug metabolism.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; DDT; Enzyme Induction; Germ-Free Life; Hydrogen-Ion Concentration; Lactones; Liver; Male; Methylcholanthrene; Oils; Organ Size; Phenobarbital; Proteins; Pyrazoles; Rats; Spironolactone | 1974 |
Effect of treatment with phenobarbital and spironolactone on 144Ce levels in blood, liver, urine and faeces at various time periods.
Topics: Animals; Cerium; Cerium Isotopes; Chlorides; Feces; Female; Liver; Male; Mice; Mice, Inbred Strains; Organ Size; Phenobarbital; Radioisotopes; Sex Factors; Spironolactone; Time Factors | 1974 |
Effect of pretreatment with spironolactone, phenobarbital or -diethylaminoethyl diphenylpropylacetate (SKF 525-A) on tritium levels in blood, heart and liver of rats at various times after administration of ( 3 H)digitoxin.
Topics: Animals; Depression, Chemical; Digitoxin; Kinetics; Liver; Male; Myocardium; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spironolactone; Stimulation, Chemical; Tritium | 1972 |
Protection against haloperidol by catatoxic steroids.
Topics: Animals; Central Nervous System; Drug Antagonism; Drug Synergism; Ethylestrenol; Female; Haloperidol; Ketones; Nitriles; Oxandrolone; Phenobarbital; Prednisolone; Pregnanes; Pregnenolone; Progesterone; Rats; Spironolactone; Thyroxine; Triamcinolone | 1972 |
Protection by catatoxic steroids and related compounds against proscillaridin intoxication.
Topics: Anabolic Agents; Androstanes; Animals; Bufanolides; Digitoxin; Ethylestrenol; Female; Glucocorticoids; Hydroxysteroids; Ketosteroids; Phenobarbital; Pregnanes; Pregnenolone; Propionates; Rats; Rats, Inbred Strains; Seizures; Spironolactone; Thyroxine | 1972 |
Effect of phenobarbital and steroids on phalloidin toxicity in rats.
Topics: Animals; Estradiol; Ethylestrenol; Female; Glucocorticoids; Liver; Microsomes, Liver; Mycotoxins; Nitriles; Phenobarbital; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Toxins, Biological | 1972 |
A comparative ultrastructural study on drug-induced proliferation of smooth-surfaced endoplasmic reticulum in hepatocytes.
Topics: Animals; Endoplasmic Reticulum; Female; Liver; Methylcholanthrene; Microscopy, Electron; Organoids; Phenobarbital; Pregnenolone; Rats; Spironolactone | 1971 |
Influence of phenobarbital and various steroids on CCl4 hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Desoxycorticosterone; Drug Synergism; Estradiol; Ethylestrenol; Female; Liver; Microsomes, Liver; Oxandrolone; Phenobarbital; Pregnanes; Progesterone; Rats; Spironolactone; Triamcinolone | 1971 |
Glucuronidation and elimination of diflunisal in the isolated perfused rat liver: effect of pretreatment with phenobarbitone, clofibric acid and spironolactone.
Topics: Animals; Bile; Biotransformation; Clofibric Acid; Diflunisal; Glucuronates; In Vitro Techniques; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Salicylates; Spironolactone | 1984 |
Nonadditive effects of combined in vivo hepatic microsomal enzyme inducers in the Wistar rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Stilbenes | 1983 |
The effects of phenobarbital, spironolactone and diazepam on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in male and female rats.
Topics: Animals; Circadian Rhythm; Diazepam; Female; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Spironolactone | 1983 |
Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats.
Topics: Animals; Dealkylation; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Sex Factors; Spironolactone; Umbelliferones | 1980 |
Bartter's syndrome.
Topics: Aldosterone; Bartter Syndrome; Brain Diseases, Metabolic; Child, Preschool; Electrolytes; Humans; Hyperaldosteronism; Infant; Male; Phenobarbital; Potassium; Renin; Spironolactone | 1981 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on rat hepatic beta-glucuronidase.
Topics: Animals; Female; Glucuronidase; Liver; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Spironolactone | 1995 |
The effect of combined pre-treatment on the metabolism of antipyrine in the rat.
Topics: Animals; Antipyrine; Enzyme Activation; Half-Life; Kinetics; Male; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Wistar; Spironolactone | 1995 |
Thyroid hyperactivity induced by methimazole, spironolactone and phenobarbital in marmosets (Callithrix jacchus): histopathology, plasma thyroid hormone levels and hepatic T4 metabolism.
Topics: Animals; Anticonvulsants; Antithyroid Agents; Biopsy; Callithrix; Cytochrome P-450 Enzyme System; Immunohistochemistry; Liver; Male; Methimazole; Microscopy, Electron; Mineralocorticoid Receptor Antagonists; Phenobarbital; Radioimmunoassay; Spironolactone; Thyroid Diseases; Thyroid Gland; Thyroxine; Triiodothyronine | 2000 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsy; Female; Kindling, Neurologic; Male; Mineralocorticoid Receptor Antagonists; Phenobarbital; Rats; Rats, Wistar; Seizures; Spironolactone; Valproic Acid | 2005 |