phenobarbital has been researched along with rifampin in 148 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (32.43) | 18.7374 |
| 1990's | 26 (17.57) | 18.2507 |
| 2000's | 42 (28.38) | 29.6817 |
| 2010's | 28 (18.92) | 24.3611 |
| 2020's | 4 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Baus, PR; Ermel, N; Kauffmann, HM; Klein, C; Schrenk, D; Vorderstemann, B | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Erdmann, F; Fischer, G; Harris, R; Hopkins, S; Huang, Z; Murray, MG; Ribeill, Y; Scorneaux, B; Smitley, C; Wring, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Amore, BM; Banfield, C; Boudreaux, MD; Davis, JA; Emery, MG; Foti, RS; Pearson, JT; Prokop, SP; Rock, DA; Wahlstrom, JL; Wienkers, LC; Wong, SL; Zalikowski, JA | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Diethelm-Varela, B; Li, L; Liang, D; Lynch, C; Wang, H; Xia, M; Xue, F | 1 |
| Kirchhof, B; Ohnhaus, EE; Peheim, E | 1 |
| Ohnhaus, EE; Park, BK | 1 |
| Heubel, F; Netter, KJ | 1 |
| Challiner, MR; Park, BK; Whittaker, AD | 1 |
| Actis, GC; Biarese, V; Giorcelli, W; Lovisetto, P | 1 |
| Remmer, H | 1 |
| Ohnhaus, EE | 1 |
| Solomonraj, G; Thomas, BH | 1 |
| Johnson, J | 1 |
| Zbinden, G | 1 |
| Natsuhori, M; Van 't Klooster, GA; Van Miert, AS; Witkamp, RF | 1 |
| Sekihara, H | 1 |
| Bammel, A; Kirch, W; Ohnhaus, EE; van der Mee, K | 1 |
| Erber, E; Parzefall, W; Schulte-Hermann, R; Sedivy, R | 1 |
| Domergue, J; Fabre, I; Joyeux, H; Maurel, P; Pichard, L | 1 |
| Beaune, PH; Flinois, JP; Guengerich, FP; Guillouzo, A; Morel, F; Ratanasavanh, D; Yang, CS | 1 |
| Liu, DY; Wang, YS | 1 |
| Bachs, L; Elena, M; Parés, A; Piera, C; Rodés, J | 1 |
| Desager, JP; Harvengt, C; Horsmans, Y; Leclercq, V; Van Nieuwenhuyze, Y | 1 |
| Gerstner, E; Heubel, F; Reuter, T | 1 |
| Breckenridge, AM; Ohnhaus, EE; Park, BK | 1 |
| Weissel, M | 1 |
| Debreczeni, LA; Herjavecz, I; Szeitz, A | 1 |
| Thomas, BH; Whitehouse, LW; Zeitz, W | 1 |
| Ryan, MP; Wosilait, WD | 1 |
| Bonfils, C; Dalet, C; Daujat, M; Guzelian, PS; Larroque, C; Li, D; Maurel, P; Pichard, L; Pompon, D | 1 |
| Eichelbaum, M; Mineshita, S; Ohnhaus, EE; Zekorn, C | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Goto, S; Hsu, KY; Noda, A; Noda, H; Ohno, K; Sendo, T | 1 |
| Gurnani, S; Rajagopalan, R | 1 |
| Bolt, HM | 2 |
| Acocella, G; Bonollo, L; Mainardi, M; Margaroli, P; Nicolis, FB | 1 |
| Curci, G; Iuliano, A; Meola, G; Ninni, A; Nitti, V | 1 |
| Mumford, JP | 1 |
| Beauchant, G; Breuil, K; Patte, F; Rautlin de la Roy Y, DE | 1 |
| Pelkonen, RO; Puukka, M; Sotaniemi, EA | 1 |
| Branch, RA; Herman, RJ | 1 |
| Elias, AN; Gwinup, G | 1 |
| Davis, M; Smith, HM; Tredger, JM; Williams, R | 1 |
| Risler, T; Seipel, L | 1 |
| Herman, RJ; Nakamura, K; Wilkinson, GR; Wood, AJ | 1 |
| Davis, M; Powell-Jackson, PR; Smith, HM; Tredger, JM; Williams, R | 1 |
| Burger, A; Bürgi, H; Ohnhaus, EE; Studer, H | 1 |
| Gerber-Taras, E; Ohnhaus, EE; Park, BK | 2 |
| Ohnhaus, EE; Studer, H | 1 |
| Back, DJ; Breckenridge, AM; Crawford, F; Cross, K; MacIver, M; Orme, ML; Rowe, PH; Smith, E | 1 |
| Bint, AJ; Burtt, I | 1 |
| Mackenroth, T; Siegers, CP; Younes, M | 1 |
| Korzhov, VI; Maliuk, VI; Molotkov, VN | 1 |
| Borisova, LN; Kovalev, IE | 1 |
| Bahri, AK; Chiang, CS; Timbrell, JA | 1 |
| Breimer, DD; Richter, E; Zilly, W | 1 |
| Goerz, G; Ruzicka, T; Vizethum, W | 1 |
| Demedts, M; Derveaux, L; Fevery, J; Gyselen, A | 1 |
| Grant, MH; Li, SJ; Rodgers, EH | 1 |
| Kostrubsky, VE; Sinclair, JF; Sinclair, PR; Strom, SC; Wood, SG; Wrighton, SA | 1 |
| Hirata, M; Nishibe, Y | 3 |
| Burke, MD; Doostdar, H; Grant, MH; Melvin, WT; Wolf, CR | 1 |
| Bachmann, KA; Jauregui, L | 1 |
| Franklin, MR | 1 |
| Huang, R; Inoue, K; Okuno, H; Shiozaki, Y; Takasu, M | 1 |
| Baba, T; Eguchi, K; Nishibe, Y; Ohno, K | 1 |
| Chang, TK; Maurel, P; Waxman, DJ; Yu, L | 1 |
| Fisher, MB; Guan, X; Koop, DR; Lang, DH; Rettie, AE; Zheng, YM | 1 |
| Kostrubsky, VE; Lewis, LD; Schuetz, EG; Schuetz, JD; Sinclair, JF; Sinclair, PR; Strom, SC; Wood, SG; Wrighton, SA | 1 |
| Azuma, J; Morisaki, T; Sumida, A; Yamamoto, I; Zhou, Q | 1 |
| Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM | 1 |
| Burke, MD; Dickins, M; Weaver, RJ | 1 |
| Fukuhara, M; Isozaki, E; Kurose, K; Tohkin, M | 1 |
| Hakkola, J; Hukkanen, J; Lassila, A; Päivärinta, K; Pelkonen, O; Raunio, H; Sarpo, S; Valanne, S | 1 |
| Endo, Y; Honma, R; Jarukamjorn, K; Kuroiwa, M; Nemoto, N; Ohara, A; Sakuma, T; Takai, M | 1 |
| Fleig, WE; Jäger, D; Köhler, C; Kostrubsky, VE; Lehmann, T; May, U; Michalopoulos, GK; Runge, D; Runge, DM; Stolz, DB; Strom, SC | 1 |
| Davies, DS; Edwards, RJ; Neubert, D; Schulz, TG; Thier, R; Wiebel, FA | 1 |
| Brunner, J; Kassahun, K; McIntosh, IS; Rodrigues, AD; Tang, C | 1 |
| Carrère, N; Daujat, M; Fabre, JM; Gerbal-Chaloin, S; Maurel, P; Pascussi, JM; Pichard-Garcia, L; Waechter, F | 1 |
| Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E | 1 |
| Gartung, C; Geier, A; Gerloff, T; Meier, PJ; Roots, I | 1 |
| Azuma, J; Fukuda, T; Fukuen, S; Kinoshita, K; Matsuda, H; Sumida, A; Takahashi, K; Yamamoto, I | 1 |
| Faucette, S; Ferguson, S; LeCluyse, EL; Moore, R; Negishi, M; Sueyoshi, T; Wang, H | 1 |
| Antonian, L; Burton, LA; Carroll, KM; Czerwinski, M; Downey, AD; Forster, J; Gan, LS; Graham, RA; Koch, P; Krueger, LA; LeCluyse, EL; Madan, A; Mudra, DR; Parkinson, A; Ribadeneira, MD; Robertson, P; Wagner, G; Yu, L; Zech, K | 1 |
| Blumenstein, I; Schirrmacher, S; Stein, J | 1 |
| Castell, JV; Donato, MT; Gómez-Lechón, MJ; Klocke, R; Paul, D; Stenzel, K | 1 |
| Azuma, J; Kinoshita, K; Matsuda, H; Matsuda, T; Matsunaga, N; Sumita, A; Takahashi, K | 1 |
| Chen, Y; Ferguson, SS; Goldstein, JA; Negishi, M | 1 |
| Buckley, AR; Buckley, DJ; Desai, PB; Glauser, TA; Hariparsad, N; Nallani, SC; Setchell, K | 1 |
| Harada, E; Ikeda, U; Ise, H; Katsuyama, Y; Maruyama, M; Matsunaga, T; Negishi, N; Ohmori, S; Sugihara, N | 1 |
| Buckley, AR; Buckley, DJ; Desai, PB; Hariparsad, N; Nallani, SC; Sane, RS | 1 |
| Chirulli, V; Fiorio, R; Gervasi, PG; Longo, V; Marini, S; Mazzaccaro, A | 1 |
| Chiba, K; Horikawa, M; Kato, M; Sugiyama, Y | 1 |
| Banks, T; Chen, L; Clark, P; Graham, RA; Krol, WL; LeCluyse, EL; Silver, IS; Tyler, LO; Webster, LO | 1 |
| de Morais, SM; Fahmi, OA; Liras, JL; Maurer, TS; Mills, JB; Ripp, SL; Trevena, KA | 1 |
| Boursier-Neyret, C; Fardel, O; Jigorel, E; Le Vee, M; Parmentier, Y | 1 |
| Cies, JJ; Giamalis, JN | 1 |
| Cai, HB; Collins, X; Edeki, TI; He, N; Strom, SC; Xie, HG | 1 |
| Hu, K; Li, D; Lin, M; Yang, XL; Yu, WJ; Zhang, SJ | 1 |
| Back, DJ; Martin, P; Owen, A; Riley, R | 1 |
| Gupta, R; Gupta, S | 1 |
| de Barros e Silva, MJ; de Paiva, TF; Fanelli, MF; Gimenes, DL; Rinck, JA | 1 |
| Honma, M; Kozawa, M; Suzuki, H | 1 |
| Castell, JV; Donato, MT; Gómez-Lechón, MJ; Lahoz, A; Picazo, L | 1 |
| Abadie-Viollon, C; Alexandre, E; Bachellier, P; Blanchard, N; Coassolo, P; Heyd, B; Mantion, G; Martin, H; Pekthong, D; Richert, L; Schuler, F | 1 |
| Boursier-Neyret, C; Cloarec, O; Croixmarie, V; Moreau, A; Pascussi, JM; Umbdenstock, T; Walther, B | 1 |
| Aso, Y; Kaneko, A; Kato, M; Mitsui, T; Sekiguchi, N; Takeda, K | 1 |
| Anthérieu, S; Camus, S; Chesné, C; Guguen-Guillouzo, C; Guillouzo, A; Lahoz, A; Li, R; Picazo, L; Tolonen, A; Turpeinen, M; Uusitalo, J | 1 |
| Bachleda, P; Dvorák, Z; Vrzal, R | 1 |
| Batteux, F; Chouzenoux, S; Dauchy, S; Declèves, X; Giraud, C; Manceau, S; Morini, JP; Perrot, JY; Scherrmann, JM; Tang, R; Tréluyer, JM; Weill, B | 1 |
| Ballent, M; Lanusse, C; Lifschitz, A; Mate, L; Virkel, G | 1 |
| Callendrello, AL; Crespi, CL; Ho, T; Stresser, DM; Zhang, JG | 1 |
| Boursier-Neyret, C; Cloarec, O; Croixmarie, V; Moreau, A; Parmentier, Y; Pascussi, JM; Umbdenstock, T; Walther, B | 1 |
| Kumar, V; Lee, CM; Morgan, ET; Riley, RI | 1 |
| Min, G | 1 |
| Hayashi, M; Shou, M; Skiles, GL; Xu, Y; Zhou, Y | 1 |
| Batheja, A; Chattopadhyay, S; Dallas, S; Sensenhauser, C; Silva, J; Singer, M | 1 |
| Hu, Y; Juréus, A; Juric, S; Lundquist, P; Sohlenius-Sternbeck, AK | 1 |
| Kuehni-Boghenbor, K; Mevissen, M; Möller, AM; Schmitz, A; Stefanski, A | 1 |
| Hori, Y; Ohara, Y; Takahashi, Y; Tanaka, H; Urashima, T; Yamamoto, T | 1 |
| Dixit, V; Hariparsad, N; Moore, A; Tsao, H | 1 |
| Almond, LM; Gardner, I; Hatley, O; Jamei, M; Kenny, JR; Mukadam, S; Okialda, K; Rostami-Hodjegan, A; Rowland-Yeo, K; Tay, S; Wong, S | 1 |
| Inoue, T; Sasaki, E; Suzuki, T; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H | 1 |
| Bao, Y; Chen, L; Piekos, SC; Zhang, L; Zhong, XB; Zhu, K | 1 |
| Abe, M; Inoue, A; Katsuda, T; Kawamata, M; Ochiya, T; Yamaguchi, T | 1 |
| Iwao, T; Koeda, A; Matsunaga, T; Mizuno, S; Nakamura, K; Nakanishi, A; Sakai, Y; Yamashita, M | 1 |
| Douxfils, J; Hainaut, P; Hardy, M; Larock, AS; Lessire, S; Mullier, F; Sennesael, AL; Spinewine, A | 1 |
| Alves, G; Falcão, A; Fortuna, A; Meirinho, S; Rodrigues, M | 1 |
6 review(s) available for phenobarbital and rifampin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Modification of peripheral thyroid hormone metabolism by drugs].
Topics: Amiodarone; Antipyrine; Dexamethasone; Heparin; Humans; Phenobarbital; Phenytoin; Propranolol; Protein Binding; Rifampin; Thiouracil; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine | 1988 |
Effects of some clinically encountered drugs on steroid synthesis and degradation.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Drug Interactions; Ethanol; Fetus; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hydroxycholecalciferols; Liver; Metyrapone; Mitotane; Phenobarbital; Phenytoin; Rifampin; Spironolactone; Steroids | 1980 |
Adverse antibiotic drug interactions.
Topics: Aminosalicylic Acid; Antacids; Anti-Bacterial Agents; Biological Availability; Contraceptives, Oral; Digitoxin; Drug Interactions; Gastrointestinal Motility; Humans; Hydrogen-Ion Concentration; Kidney; Metals; Phenobarbital; Phenytoin; Rifampin; Sulfonamides; Tetracyclines; Warfarin | 1980 |
Treatment of cholestatic pruritus in children.
Topics: Antipruritics; Child; Cholagogues and Choleretics; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Cholestyramine Resin; Histamine H1 Antagonists; Humans; Narcotic Antagonists; Phenobarbital; Pruritus; Rifampin; Ursodeoxycholic Acid | 2007 |
4 trial(s) available for phenobarbital and rifampin
| Article | Year |
|---|---|
A comparison of three different enzyme inducing agents and their influence on plasma lipids in man [proceedings].
Topics: Antipyrine; Enzyme Induction; Humans; Lipids; Phenobarbital; Rifampin | 1977 |
Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.
Topics: Adult; Cholestasis; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Liver Cirrhosis, Biliary; Microsomes, Liver; Middle Aged; Phenobarbital; Pruritus; Random Allocation; Rifampin; Severity of Illness Index | 1989 |
The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man.
Topics: Adult; Antipyrine; Enzyme Induction; Female; Humans; Male; Microsomes, Liver; Phenobarbital; Rifampin; Thyroid Hormones; Thyrotropin; Thyroxine | 1981 |
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo.
Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid | 1993 |
138 other study(ies) available for phenobarbital and rifampin
| Article | Year |
|---|---|
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Up-regulation of transporters of the MRP family by drugs and toxins.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Carrier Proteins; Gene Expression Regulation; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Toxins, Biological; Up-Regulation | 2001 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cyclophilin A; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Haplorhini; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukocytes, Mononuclear; Mice; Molecular Structure; Rats; RNA, Viral; Virus Replication | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors.
Topics: Adolescent; Adult; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Glucuronosyltransferase; Hepatocytes; Humans; Ketoconazole; Kinetics; Lung; Male; Microsomes, Liver; Middle Aged; Phenylacetates; Prostaglandins; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Young Adult | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor.
Topics: | 2019 |
Effect of enzyme induction on plasma lipids using antipyrine, phenobarbital, and rifampicin.
Topics: 17-Hydroxycorticosteroids; Adult; Antipyrine; Cholesterol; Enzyme Induction; Female; gamma-Glutamyltransferase; Glucaric Acid; Humans; Hydrocortisone; Hydroxylation; Lipids; Lipoproteins; Male; Microsomes, Liver; Phenobarbital; Phospholipids; Rifampin; Triglycerides | 1979 |
Measurement of urinary 6-beta-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicin.
Topics: 17-Hydroxycorticosteroids; Adult; Antipyrine; Enzyme Induction; Female; gamma-Glutamyltransferase; Glucaric Acid; Humans; Hydrocortisone; Hydroxylation; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rifampin | 1979 |
Atypical inductive properties of rifampicin.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rifampin; Sleep; Time Factors | 1979 |
The effect of enzyme induction on the irreversible binding of ethynyloestradiol to guinea pig liver microsomes.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Ethinyl Estradiol; Flavonoids; Guinea Pigs; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rifampin; Spironolactone | 1978 |
[Gilbert's jaundice. Current clinico-nosographic, physiopathological and therapeutic aspects. III. Therapeutic action of enzyme inductors with reference to unconjugated bilirubin icterus].
Topics: Adult; Enzyme Induction; Female; Gilbert Disease; Glucuronates; Humans; Hyperbilirubinemia, Hereditary; Mixed Function Oxygenases; Phenobarbital; Rifampin; Transferases | 1977 |
[Biotransformation and its modification by barbiturates].
Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Liver Diseases; Phenobarbital; Phenytoin; Rifampin | 1977 |
Drug interactions with isoniazid metabolism in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspirin; Drug Interactions; Ethambutol; Ethanol; Injections, Intravenous; Isoniazid; Male; Phenobarbital; Rats; Rifampin; Time Factors; Tissue Distribution | 1977 |
Letter: Epanutin and isoniazid interaction.
Topics: Adult; Carbamazepine; Drug Interactions; Electroencephalography; Epilepsy; Ethambutol; Ethosuximide; Female; Humans; Isoniazid; Phenobarbital; Phenytoin; Rifampin | 1975 |
[Dangers of drug combinations (author's transl)].
Topics: Anticoagulants; Barbiturates; Contraceptives, Oral, Hormonal; Drug Antagonism; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Imipramine; Intestinal Absorption; Monoamine Oxidase Inhibitors; Phenobarbital; Phenytoin; Psychoses, Substance-Induced; Rifampin | 1976 |
Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin.
Topics: Animals; Antipyrine; Biotransformation; Enzyme Induction; Female; Goats; Male; Oxidation-Reduction; Phenobarbital; Rifampin; Sulfamethazine; Troleandomycin | 1992 |
[Drug enhancement of cortisol and glucocorticoid metabolism].
Topics: Adrenal Insufficiency; Drug Interactions; Ephedrine; Half-Life; Humans; Hydrocortisone; Methylprednisolone; Phenobarbital; Phenytoin; Prednisolone; Rifampin | 1992 |
Divergent effects of different enzyme-inducing agents on endogenous and exogenous testosterone.
Topics: Adult; Antipyrine; Biotransformation; Enzyme Induction; Gonadotropins, Pituitary; Humans; Male; Microsomes, Liver; Phenobarbital; Rifampin; Testosterone | 1992 |
Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters.
Topics: Adult; Aged; Autoradiography; Carcinogens; Cyproterone; Cyproterone Acetate; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Gene Expression Regulation; Hexachlorocyclohexane; Humans; In Vitro Techniques; Liver; Male; Middle Aged; Nafenopin; Phenobarbital; Recombinant Proteins; Rifampin | 1991 |
Effect of FK 506 on human hepatic cytochromes P-450: interaction with CyA.
Topics: Cells, Cultured; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Isoenzymes; Liver; Microsomes, Liver; Phenobarbital; Rifampin; Tacrolimus | 1991 |
Expression of cytochrome P-450 enzymes in cultured human hepatocytes.
Topics: Adult; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Immunoenzyme Techniques; Infant, Newborn; Isoenzymes; Liver; Methylcholanthrene; Phenobarbital; Rifampin; RNA, Messenger | 1990 |
Inductive effects of rifapentine on mice hepatic mixed function oxidase system.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Leprostatic Agents; Liver; Male; Mice; Mixed Function Oxygenases; Organ Size; Phenobarbital; Rifampin | 1990 |
Influence of rifampicin, phenobarbital and cimetidine on mixed function monooxygenase in extensive and poor metabolizers of debrisoquine.
Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Debrisoquin; Half-Life; Humans; Hydroxylation; Isoquinolines; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Rifampin | 1989 |
Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone.
Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Rifampin; Warfarin | 1989 |
Urinary excretion of 6 beta-hydroxycortisol and the time course measurement of enzyme induction in man.
Topics: Adult; Antipyrine; Enzyme Induction; Female; Humans; Hydrocortisone; Kinetics; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rifampin; Time Factors | 1989 |
Effects of drugs on aminophylline elimination in rats.
Topics: Aminophylline; Animals; Behavior, Animal; Carbamazepine; Cimetidine; Drug Combinations; Drug Interactions; Erythromycin; Female; Half-Life; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
Effect of rifampin, phenobarbital pretreatment, and acetylator phenotype on acetylisoniazid metabolism in the rabbit.
Topics: Acetylation; Animals; Isoniazid; Kinetics; Liver; Male; Phenobarbital; Phenotype; Protein Binding; Rabbits; Rifampin; Tissue Distribution | 1987 |
Drug interactions affecting the elimination of doxorubicin in the rat.
Topics: Animals; Bile; Carbon Tetrachloride; Doxorubicin; Drug Interactions; Kinetics; Male; Phenobarbital; Rats; Rats, Inbred Strains; Rifampin; Sulfobromophthalein; Tissue Distribution | 1987 |
Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Male; Microsomes, Liver; Phenobarbital; Rabbits; Rifampin; RNA, Messenger | 1987 |
The influence of enzyme induction on polymorphic sparteine oxidation.
Topics: Adult; Antipyrine; Enzyme Induction; Female; Half-Life; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Middle Aged; Oxidation-Reduction; Phenobarbital; Rifampin; Sparteine | 1986 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats.
Topics: Acetylation; Animals; Drug Interactions; Hydrazines; Isoniazid; Liver; Male; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Rifampin | 1985 |
Effect of rifampicin on the biological activity of tubulin.
Topics: Animals; Brain Chemistry; Cattle; Chromatography, Gel; Colchicine; Dapsone; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Microtubules; Phenobarbital; Rifampin; Spectrophotometry; Tubulin | 1985 |
[Drug interactions in the use of steroid hormones, especially oral contraceptives].
Topics: Biotransformation; Contraceptives, Oral, Hormonal; Cytochrome P-450 CYP1A1; Drug Interactions; Female; Humans; Hydroxylation; Liver; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Rifampin; Steroid Hydroxylases | 1985 |
Kinetic studies on rifampicin. III. Effect of phenobarbital on the half-life of the antibiotic.
Topics: Adult; Aged; Drug Interactions; Half-Life; Humans; Kinetics; Male; Middle Aged; Phenobarbital; Rifampin | 1974 |
Comparative investigations of the enzyme-inducing activity of rifampicin and barbiturates in man.
Topics: Adult; Bilirubin; Enzyme Induction; Half-Life; Humans; Kinetics; Male; Phenobarbital; Rifampin; Time Factors | 1973 |
Letter: Drugs affecting oral contraceptives.
Topics: Ampicillin; Contraceptives, Oral; Drug Interactions; Enzyme Induction; Estriol; Estrogens; Female; Humans; Phenobarbital; Pregnancy; Rifampin | 1974 |
[Reduction of the blood level of rifampicin by phenobarbital].
Topics: Humans; Phenobarbital; Rifampin; Tuberculosis | 1971 |
Measurement of hepatic drug-metabolizing enxyme activity in man. Comparison of three different assays.
Topics: Adult; Aged; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucaric Acid; Hepatitis; Histamine H1 Antagonists; Humans; Liver; Liver Cirrhosis; Male; Medroxyprogesterone; Middle Aged; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Prednisolone; Rifampin | 1980 |
Enzyme induction and beta-adrenergic receptor blocking drugs.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antipyrine; Drug Interactions; Enzyme Induction; Half-Life; Humans; Kinetics; Middle Aged; Phenobarbital; Propranolol; Rifampin; Smoking | 1984 |
Use of a direct high performance liquid chromatography method for multiple testosterone hydroxylations in studies of microsomal monooxygenase activities.
Topics: Acetanilides; Aldrin; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Ethylmorphine; Male; Mesocricetus; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; Testosterone | 1984 |
[Controlled digitalis therapy].
Topics: Cholestyramine Resin; Digitalis Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Heart Failure; Humans; Patient Compliance; Phenobarbital; Quinidine; Rifampin | 1983 |
Induction of propranolol metabolism by rifampicin.
Topics: Adult; Drug Interactions; Enzyme Induction; Humans; Male; Metabolic Clearance Rate; Phenobarbital; Propranolol; Rifampin | 1983 |
Effect of rifampicin on the mouse hepatic mixed-function oxidase system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rifampin; Sodium Fluoride | 1981 |
Enzyme-inducing drug combinations and their effects on liver microsomal enzyme activity in man.
Topics: Adult; Antipyrine; Drug Combinations; Enzyme Induction; Female; Humans; Hydrocortisone; Male; Microsomes, Liver; Phenobarbital; Rifampin | 1983 |
A link between liver microsomal enzyme activity and thyroid hormone metabolism in man.
Topics: Adult; Antipyrine; Enzyme Induction; Female; Humans; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rifampin; Thyroid Hormones | 1983 |
Influence of environmental chemicals on drug therapy in humans: studies with contraceptive steroids.
Topics: Animals; Antipyrine; Contraceptives, Oral; Environment; Ethinyl Estradiol; Female; Half-Life; Humans; Intestinal Mucosa; Jejunum; Kinetics; Norethindrone; Norgestrel; Phenobarbital; Rats; Rifampin | 1980 |
[Inhibition and acceleration of the metabolism of enflurane and methoxyflurane in rats (author's transl)].
Topics: Animals; DDT; Dimethyl Sulfoxide; Drug Interactions; Enflurane; Ethanol; Half-Life; Male; Maleates; Methoxyflurane; Phenobarbital; Rats; Rifampin | 1981 |
[Metabolic disorders in acute poisoning and their correction by sodium succinate].
Topics: Animals; Antitubercular Agents; Ethionamide; Guinea Pigs; Isoniazid; Phenobarbital; Poisoning; Rifampin; Succinates | 1981 |
[Effect of inducers of mixed-function microsomal oxidases on the immune response of mice induced by heterologous erythrocytes].
Topics: Animals; Anti-Anxiety Agents; Antibody Formation; Benzodiazepines; Benzodiazepinones; Cytochrome P-450 Enzyme System; DDT; Diazepam; Enzyme Induction; Erythrocytes; Male; Methylcholanthrene; Mice; Phenobarbital; Phenytoin; Rifampin; Sheep | 1981 |
The estimation of 6 beta-hydroxycortisol in urine -- a comparison of two methods: high performance liquid chromatography and radioimmunoassay.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Humans; Hydrocortisone; Phenobarbital; Radioimmunoassay; Rifampin | 1981 |
Acetylhydrazine hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Hydrazines; Isoniazid; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Rifampin | 1981 |
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents.
Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobarbital; Humans; Inactivation, Metabolic; Kinetics; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Phenytoin; Rifampin | 1980 |
Inducibility of drug-metabolizing enzymes in the rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rifampin; Skin | 1980 |
[Fulminating hepatitis caused by administration of isoniazid and rifampicin in a patient under chronic treatment with barbiturates].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Hepatic Encephalopathy; Humans; Isoniazid; Phenobarbital; Rifampin; Tuberculosis, Miliary | 1980 |
The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents.
Topics: Benz(a)Anthracenes; Breast Neoplasms; Cell Death; Cytochrome P-450 Enzyme System; Dexamethasone; Dicumarol; Enzyme Induction; Female; Glutathione; Glutathione Peroxidase; Humans; L-Lactate Dehydrogenase; Metyrapone; Mitoxantrone; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rifampin; Tumor Cells, Cultured; Xenobiotics | 1995 |
Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes.
Topics: Adolescent; Adult; Alcohol Drinking; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Humans; Liver; Male; Middle Aged; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Pentanols; Phenobarbital; Rifampin; RNA, Messenger | 1995 |
Interactions between clinically used drugs and oral contraceptives.
Topics: Animals; Contraceptives, Oral; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Estrogens; Female; Humans; Hydroxylation; Liver Circulation; Mice; Pharmaceutical Preparations; Phenobarbital; Rats; Rifampin | 1994 |
Induction of cytochrome P-450 isoenzymes in cultured monkey hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Liver; Male; Oxidoreductases, O-Demethylating; Phenobarbital; Rifampin; Saimiri; Steroid Hydroxylases | 1995 |
Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Omeprazole; Oxidoreductases; Phenobarbital; Rifampin; Steroid 16-alpha-Hydroxylase | 1993 |
The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells.
Topics: Benz(a)Anthracenes; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Glucuronosyltransferase; Humans; Mixed Function Oxygenases; Phenobarbital; Rifampin; Tumor Cells, Cultured | 1993 |
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases | 1995 |
Enhanced rates of cytochrome P450 metabolic-intermediate complex formation from nonmacrolide amines in rifampicin-treated rabbit liver microsomes.
Topics: Amines; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rabbits; Rifampin | 1995 |
Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Lipid Peroxidation; Liver Diseases; Male; Mice; Mice, Inbred Strains; Phenobarbital; Rifampin; Transaminases | 1995 |
Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Male; Microsomes, Liver; Phenobarbital; Rifampin; Steroid Hydroxylases | 1996 |
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biotransformation; Cells, Cultured; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Humans; Hydroxylation; Ifosfamide; Isoenzymes; Kinetics; Liver; Male; Middle Aged; Phenobarbital; Prodrugs; Rifampin | 1997 |
Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid.
Topics: Acetone; Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Carcinogens; Catalysis; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Isoenzymes; Lauric Acids; Microsomes, Liver; NADP; Phenobarbital; Rabbits; Rifampin; Stereoisomerism | 1998 |
Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Child, Preschool; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Immunoblotting; Liver; Male; Middle Aged; Oxidoreductases, N-Demethylating; Paclitaxel; Phenobarbital; Rifampin; RNA, Messenger | 1998 |
Evaluation of induction of CYP3A mRNA using the HepG2 cell line and reverse transcription-PCR.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Hepatoblastoma; Humans; Liver Neoplasms; Oxidoreductases, N-Demethylating; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Tumor Cells, Cultured | 1999 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics | 1999 |
A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man.
Topics: Adult; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Immunoblotting; Macaca fascicularis; Male; Microsomes, Liver; Middle Aged; Phenobarbital; Rifampin; Steroid Hydroxylases | 1999 |
Cloning and expression analysis of a new member of the cytochrome P450, CYP2A15 from the Chinese hamster, encoding testosterone 7alpha-hydroxylase.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cloning, Molecular; Cricetinae; Cytochrome P-450 Enzyme System; DNA, Complementary; Female; Gene Expression; Hydroxylation; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes; Molecular Sequence Data; Phenobarbital; Phylogeny; Recombinant Proteins; Rifampin; Steroid Hydroxylases; Testosterone; Tissue Distribution | 1999 |
Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line.
Topics: Adenocarcinoma; Anti-Inflammatory Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Epithelial Cells; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phenobarbital; Pulmonary Alveoli; Rifampin; RNA, Messenger; Tumor Cells, Cultured; Xenobiotics | 2000 |
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Castration; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Liver; Male; Membrane Proteins; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; RNA, Messenger; Sex Characteristics; Sexual Maturation; Testosterone | 2000 |
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; beta-Naphthoflavone; Blotting, Western; Cell Size; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Isoenzymes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenobarbital; Rifampin; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Vault Ribonucleoprotein Particles | 2000 |
Identification of theta-class glutathione S-transferase in liver cytosol of the marmoset monkey.
Topics: Animals; Callithrix; Chromatography, Affinity; Clofibric Acid; Cytosol; Dinitrochlorobenzene; Epoxy Compounds; Glutathione Transferase; Humans; Liver; Methyl Chloride; Methylene Chloride; Mice; Mice, Inbred BALB C; Nitrophenols; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Wistar; Rifampin; Species Specificity | 2000 |
Simultaneous determination of urinary free cortisol and 6beta-hydroxycortisol by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry and its application for estimating hepatic CYP3A induction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Atmospheric Pressure; Chromatography, High Pressure Liquid; Corticosterone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrocortisone; Liver; Macaca mulatta; Mass Spectrometry; Models, Animal; Oxidoreductases, N-Demethylating; Phenobarbital; Rifampin; Sensitivity and Specificity | 2000 |
Induction of CYP2C genes in human hepatocytes in primary culture.
Topics: Adult; Aged; Cell Line; Cells, Cultured; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cytochrome P-450 Enzyme System; Dactinomycin; Dexamethasone; Enzyme Induction; Female; Hepatocytes; Humans; Hydroxylation; Immunoblotting; Isoenzymes; Kinetics; Liver; Male; Middle Aged; Nuclease Protection Assays; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Receptors, Virus; Rifampin; RNA, Messenger; Tyrosine Transaminase | 2001 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
Functional analysis of the rat bile salt export pump gene promoter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Base Sequence; Bile Acids and Salts; Binding Sites; Dexamethasone; DNA-Binding Proteins; Feedback; Gene Expression Regulation; Genes; Genes, Reporter; Hepatoblastoma; Hepatocytes; Humans; Hydrocortisone; Liver Neoplasms; Molecular Sequence Data; Phenobarbital; Promoter Regions, Genetic; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rifampin; Tamoxifen; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Xenobiotics | 2002 |
Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line.
Topics: Aryl Hydrocarbon Hydroxylases; beta-Alanine; Cell Line; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Humans; Oxidoreductases, N-Demethylating; Phenobarbital; Rifampin; Taurine; Time Factors | 2002 |
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
Topics: Amino Acid Motifs; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Constitutive Androstane Receptor; Cyclophosphamide; Cytochrome P-450 CYP2B6; Dimerization; Gene Expression Regulation; Genes, Reporter; Hepatocytes; Humans; Ifosfamide; Ligands; Liver; Luciferases; Mice; Microsomes, Liver; Mutagenesis, Site-Directed; Oxidoreductases, N-Demethylating; Phenobarbital; Plasmids; Pregnane X Receptor; Promoter Regions, Genetic; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Xenobiotics | 2003 |
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hepatocytes; Humans; Isoniazid; Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Rifampin | 2003 |
[Pathogenesis and treatment of pruritus in patients with cholestasis].
Topics: Brain; Cholestasis; Cholestyramine Resin; Dronabinol; Enzyme Induction; Humans; Liver; Narcotic Antagonists; Ondansetron; Opioid Peptides; Phenobarbital; Pruritus; Rifampin; Skin; Synaptic Transmission; Treatment Outcome | 2003 |
Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice.
Topics: Animals; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Gene Expression; Hepatocytes; Hydroxylation; Liver; Methylcholanthrene; Mice; Mice, Transgenic; Phenobarbital; Rifampin; RNA, Messenger; Testosterone; Transcription Factors | 2003 |
Modulation of taurine on CYP3A4 induction by rifampicin in a HepG2 cell line.
Topics: Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Taurine | 2003 |
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.
Topics: Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Binding Sites; Bridged Bicyclo Compounds; Cytochrome P-450 CYP2C9; Enzyme Induction; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Humans; Phenobarbital; Phloroglucinol; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Terpenes; Transcriptional Activation; Tumor Cells, Cultured | 2004 |
Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate.
Topics: Animals; Anticonvulsants; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Fibroblasts; Fructose; Hepatocytes; Humans; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; RNA, Messenger; Testosterone; Topiramate; Transcription, Genetic; Transfection | 2003 |
Expression and induction of CYP3As in human fetal hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Fetus; Hepatocytes; Humans; Insecta; Microsomes; Mifepristone; Phenobarbital; Receptors, Glucocorticoid; Rifampin; RNA, Messenger; Tretinoin | 2004 |
Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cells, Cultured; Cyclopropanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hepatocytes; Humans; Oxazines; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; RNA, Messenger | 2004 |
CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs.
Topics: Air Pollutants; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Calcium-Binding Proteins; Clotrimazole; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Eye Proteins; Isoenzymes; Lipoproteins; Lung; Male; Organ Specificity; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phenobarbital; Pregnane X Receptor; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recoverin; Rifampin; Species Specificity | 2005 |
The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes.
Topics: Area Under Curve; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Liver; Phenobarbital; Predictive Value of Tests; Rifampin | 2005 |
Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes.
Topics: Animals; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hepatocytes; Kinetics; Male; Phenobarbital; Rifampin; RNA, Messenger; Species Specificity | 2006 |
Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.
Topics: Algorithms; Carbamazepine; Cell Line; Cell Proliferation; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Nifedipine; Phenobarbital; Phenytoin; Pioglitazone; Reproducibility of Results; Rifampin; Rosiglitazone; Sulfinpyrazone; Thiazolidinediones | 2006 |
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; NF-E2-Related Factor 2; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Pyrazines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Symporters; Thiones; Thiophenes; Transcription Factors; Xenobiotics | 2006 |
Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B.
Topics: Adult; Aged; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Induction; Female; Ginkgolides; Hepatocytes; Herb-Drug Interactions; Humans; Hydroxylation; Lactones; Male; Middle Aged; Phenobarbital; Quercetin; Rifampin; Testosterone | 2007 |
Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp (Ctenopharyngodon idellus): Possible implications for the establishment of a fish CYP3A induction model.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Bass; Carps; Cell Culture Techniques; Cell Line; Cytochrome P-450 CYP3A; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Erythromycin; Fish Proteins; Hepatocytes; Kidney; Kinetics; Liver; Microsomes, Liver; Models, Animal; Phenobarbital; Rifampin; Steroid Hydroxylases; Substrate Specificity; Testosterone | 2008 |
Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Culture Techniques; Cells, Cultured; Chenodeoxycholic Acid; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Induction; Epithelial Cells; Hepatocytes; Humans; Intestinal Mucosa; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Research Design; Rifampin; RNA, Messenger; Transcription Factors; Up-Regulation | 2008 |
Exanthematous allergic drug reactions due to four chemically unrelated drugs.
Topics: Adult; Antibiotics, Antitubercular; Anticonvulsants; Antitubercular Agents; Erythema; Ethambutol; Exanthema; Female; Humans; Phenobarbital; Phenytoin; Pruritus; Rifampin | 2008 |
Tuberculosis in a patient on temozolomide: a case report.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Anticholesteremic Agents; Anticonvulsants; Antineoplastic Agents, Alkylating; Atorvastatin; Brain Neoplasms; Combined Modality Therapy; Cyclosporine; Dacarbazine; Dexamethasone; Female; Fluoxetine; Glioblastoma; Heptanoic Acids; Humans; Immunosuppressive Agents; Isoniazid; Middle Aged; Omeprazole; Phenobarbital; Prednisone; Pyrazinamide; Pyrroles; Radiotherapy; Red-Cell Aplasia, Pure; Rifampin; Temozolomide; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Pulmonary | 2009 |
Quantitative prediction of in vivo profiles of CYP3A4 induction in humans from in vitro results with a reporter gene assay.
Topics: Biotechnology; Cytochrome P-450 CYP3A; Enzyme Induction; Genes, Reporter; Hepatocytes; Humans; Mathematical Computing; Phenobarbital; Rifampin; Time Factors; Transfection | 2009 |
Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Reproducibility of Results; Rifampin; Tandem Mass Spectrometry | 2008 |
Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions.
Topics: Adult; Aged; Antibiotics, Antitubercular; beta-Naphthoflavone; Cell Culture Techniques; Cell Separation; Cryopreservation; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Follow-Up Studies; Hepatocytes; Humans; Indicators and Reagents; Isoenzymes; Male; Middle Aged; Omeprazole; Phenobarbital; Proton Pump Inhibitors; Reference Standards; Rifampin; RNA, Messenger; Young Adult | 2010 |
Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.
Topics: Biomarkers; Chromatography, Liquid; Constitutive Androstane Receptor; Excitatory Amino Acid Antagonists; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Nucleic Acid Synthesis Inhibitors; Oximes; Phenobarbital; Rifampin; Thiazoles | 2009 |
In vitro model for the prediction of clinical CYP3A4 induction using HepaRG cells.
Topics: Anticonvulsants; Biological Assay; Carbamazepine; Cell Line; Cytochrome P-450 CYP3A; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Humans; Phenobarbital; Rifampin | 2009 |
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.
Topics: Cell Culture Techniques; Cell Differentiation; Cell Line, Transformed; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Enzyme Induction; Gene Expression Regulation; Glucuronosyltransferase; Glutathione Transferase; Hepatocytes; Humans; Isoenzymes; Membrane Transport Proteins; Omeprazole; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; Rifampin; RNA, Messenger; Time Factors; Xenobiotics | 2010 |
Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes.
Topics: Anisomycin; Aryl Hydrocarbon Hydroxylases; Dioxins; Enzyme Activation; Enzyme Activators; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Glucuronosyltransferase; Glutathione Transferase; Hepatocytes; Humans; Phenobarbital; Rifampin; RNA, Messenger; Sorbitol; Sulfotransferases | 2009 |
Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Constitutive Androstane Receptor; Drug Interactions; Flow Cytometry; HL-60 Cells; Humans; Lymphocytes; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; RNA, Messenger; Time Factors; Transfection; Up-Regulation | 2010 |
Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition.
Topics: Animals; Antiparasitic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Gastrointestinal Tract; Intestines; Ivermectin; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Rifampin | 2010 |
A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin.
Topics: Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biological Assay; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Endpoint Determination; Enzyme Induction; Hepatocytes; Humans; Oxidoreductases, N-Demethylating; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Substrate Specificity; Time Factors | 2010 |
Metabonomic studies on human hepatocyte in primary culture.
Topics: Cells, Cultured; Constitutive Androstane Receptor; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Models, Biological; Oximes; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Thiazoles | 2010 |
Metabolism and action of proteasome inhibitors in primary human hepatocytes.
Topics: Adolescent; Adult; Cells, Cultured; Cytochrome P-450 CYP3A Inhibitors; Female; Hepatocytes; Humans; Infant; Ketoconazole; Leupeptins; Male; Middle Aged; Nitric Oxide; Phenobarbital; Protease Inhibitors; Proteasome Inhibitors; Rifampin | 2010 |
Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells.
Topics: Constitutive Androstane Receptor; Corticosterone; Estrogens; Ethinyl Estradiol; Hep G2 Cells; Humans; Liver; Liver X Receptors; Orphan Nuclear Receptors; Phenobarbital; Pregnane X Receptor; Pyridines; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Rifampin; Transcriptional Activation | 2010 |
Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs.
Topics: Area Under Curve; Carbamazepine; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Midazolam; Nifedipine; Phenobarbital; Rifampin; Simvastatin; Substrate Specificity | 2011 |
Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes.
Topics: beta-Naphthoflavone; C-Reactive Protein; Cells, Cultured; Cytochrome P-450 Enzyme System; Gene Expression; Hepatocytes; Humans; Interleukin-12; Interleukin-23; Interleukin-6; Liver; Phenobarbital; Receptors, Interleukin; Receptors, Interleukin-12; Rifampin; Tumor Necrosis Factor-alpha | 2013 |
The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport.
Topics: Cell Culture Techniques; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP3A; Estrone; Fluorobenzenes; Hepatocytes; Humans; Ipratropium; Liver; Organic Anion Transporters; Phenobarbital; Pyrimidines; Rifampin; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Taurocholic Acid | 2013 |
Induction of cytochrome P450 enzymes in primary equine hepatocyte culture.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antitubercular; Cell Survival; Cells, Cultured; Coumarins; Culture Media, Serum-Free; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Enzyme Induction; Hepatocytes; Horses; Hypnotics and Sedatives; Immunohistochemistry; Indicators and Reagents; Kinetics; Phenobarbital; Rifampin; Veterinary Drugs | 2013 |
3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells.
Topics: Albumins; Apolipoproteins B; Cell Culture Techniques; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Glucose; Hep G2 Cells; High-Throughput Screening Assays; Humans; Lipid Metabolism; Lipoproteins, LDL; Liver; Omeprazole; Phenobarbital; Rifampin; Spheroids, Cellular; Transcriptome | 2015 |
Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes.
Topics: Biological Transport; Cells, Cultured; Coculture Techniques; Cytochrome P-450 Enzyme System; Half-Life; Hepatocytes; Humans; Phenobarbital; Phenytoin; Rifampin; RNA, Messenger; Xenobiotics | 2016 |
Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.
Topics: Administration, Oral; Carbamazepine; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Gastrointestinal Tract; Hepatocytes; Humans; Liver; Models, Biological; Phenobarbital; Phenytoin; Rifampin; RNA, Messenger | 2016 |
Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents.
Topics: Animals; Callithrix; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Drug Evaluation, Preclinical; Drug Interactions; Feasibility Studies; Hepatocytes; Humans; Macaca fascicularis; Male; Models, Animal; Omeprazole; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; Rifampin | 2017 |
A Transcriptional Regulatory Network Containing Nuclear Receptors and Long Noncoding RNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells.
Topics: Cell Line; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Gene Regulatory Networks; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Liver; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Rifampin; RNA, Long Noncoding; Transcriptional Activation | 2018 |
Long-term maintenance of functional primary human hepatocytes using small molecules.
Topics: Amides; Cell Proliferation; Cells, Cultured; Cytochrome P-450 Enzyme System; Glycogen; Hepatocytes; Humans; Phenobarbital; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Rifampin; Urea | 2020 |
Comparison of the inducibility of CYP mRNA exposed to typical inducers in fresh and cryopreserved cynomolgus monkey hepatocytes.
Topics: Animals; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Hepatocytes; Liver; Macaca fascicularis; Male; Omeprazole; Phenobarbital; Rifampin; RNA, Messenger | 2020 |
The Impact of Strong Inducers on Direct Oral Anticoagulant Levels.
Topics: Administration, Oral; Aged; Anticoagulants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Drug Interactions; Drug Monitoring; Female; Humans; Male; Phenobarbital; Phenytoin; Retrospective Studies; Rifampin | 2021 |
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Dioxolanes; Drug Interactions; Humans; Nitriles; Phenobarbital; Pyridones; Rifampin; Triazoles | 2022 |