phenobarbital has been researched along with pyridine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 11 (61.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dunn, WJ; Grigoras, S; Koehler, MG | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Caron, G; Ermondi, G | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Kim, SG; Novak, RF | 1 |
| Baden, I; Hlavica, P; Mietaschk, J | 1 |
| Brown, PI; Lo, HH; Rankin, GO; Valentovic, MA | 1 |
| Carlson, GP | 2 |
| Hollenberg, PF; Shu, L | 1 |
| Carlson, GP; DeNicola, DB; Gadberry, MG | 1 |
| Ferrara, R; King, LJ; Manno, M; Tolando, R | 1 |
| Albores, A; Eldirdiri, NI; Ferrara, R; King, LJ; Manno, M; Tolando, R | 1 |
| Carlson, GP; DeNicola, DB; Felten, RK | 1 |
| Jeong, HG | 1 |
| Novak, RF; Woodcroft, KJ | 1 |
| Edwards, RJ; Guengerich, FP; Hollenberg, PF; Kim, H; Novak, RF; Putt, DA; Wolf, CR; Zangar, RC | 1 |
| Bortolato, S; Ferrara, R; Manno, M; Tolando, R; White, IN; Zanovello, A | 1 |
18 other study(ies) available for phenobarbital and pyridine
| Article | Year |
|---|---|
The role of solvent-accessible surface area in determining partition coefficients.
Topics: Diffusion; Solubility; Solvents; Structure-Activity Relationship | 1987 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
Topics: Animals; Biotransformation; Catalase; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Safrole; Smoke; Superoxide Dismutase; Superoxides | 1990 |
Interaction of ligands with cytochrome P-450. On the 442 nm spectral species generated during the oxidative metabolism of pyridine.
Topics: Animals; Cytochrome P-450 Enzyme System; Dithiothreitol; Female; In Vitro Techniques; Kinetics; Ligands; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Spectrophotometry | 1982 |
3,5-Dichloroaniline toxicity in Fischer 344 rats pretreated with inhibitors and inducers of cytochrome P450.
Topics: Alanine Transaminase; Analysis of Variance; Aniline Compounds; Animals; Benzoflavones; beta-Naphthoflavone; Blood Urea Nitrogen; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Kidney Cortex; Liver; Male; Organ Size; Oxazoles; p-Aminohippuric Acid; Phenobarbital; Piperonyl Butoxide; Pyridines; Rats; Rats, Inbred F344 | 1995 |
The effect of inducers and inhibitors of urethane metabolism on its in vitro and in vivo metabolism in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Dioxide; Ditiocarb; Ethanol; In Vitro Techniques; Male; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; Urethane | 1994 |
Role of cytochrome P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cells, Cultured; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; DNA Damage; DNA Repair; Enzyme Induction; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Inbred F344; Steroid Hydroxylases | 1996 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Epoxy Compounds; gamma-Glutamyltransferase; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Lung Diseases; Male; Methionine Sulfoximine; Mice; Phenobarbital; Pyridines; Styrene; Styrenes; Trichloroepoxypropane | 1996 |
Cytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital- and pyridine-induced rat liver microsomes.
Topics: Animals; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cytochrome b Group; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Free Radicals; Gas Chromatography-Mass Spectrometry; Glutathione; Isoenzymes; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyridines; Rats; Rats, Wistar; Time Factors | 1997 |
Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450.
Topics: Alkenes; Anaerobiosis; Animals; Biotransformation; Carbon Monoxide; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cyclic N-Oxides; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione; Heme; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Pyridines; Rats; Rats, Wistar | 1996 |
Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice.
Topics: Animals; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Induction; Enzyme Inhibitors; Epoxy Compounds; Injections, Intraperitoneal; Lung; Male; Mice; Microsomes; Microsomes, Liver; Phenobarbital; Pyridines; Species Specificity; Styrene; Styrenes | 1997 |
Minimal effects of acrylonitrile on pulmonary and hepatic cell injury enzymes in rats with induced cytochrome P450.
Topics: Acetone; Acrylonitrile; Animals; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; gamma-Glutamyltransferase; Isoenzymes; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Lung; Male; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley | 1998 |
Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice.
Topics: Aniline Hydroxylase; Animals; Blotting, Northern; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid; Oxidoreductases; Phenobarbital; Protein Isoforms; Pyridines; Saponins; Time Factors | 1998 |
Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Cells, Cultured; Clofibric Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Insulin; Liver; Male; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Xenobiotics | 1999 |
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Clofibrate; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dactinomycin; Deoxyadenosines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Alignment; Transcription, Genetic | 2001 |
Bioactivation and toxicity in vitro of HCFC-123 and HCFC-141b: role of cytochrome P450.
Topics: Animals; Biotransformation; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cytochrome P-450 Enzyme System; Excitatory Amino Acid Antagonists; Free Radicals; Glutathione; Hepatocytes; L-Lactate Dehydrogenase; Male; Microsomes, Liver; Phenobarbital; Pyridines; Rats; Rats, Wistar | 2001 |