phenobarbital has been researched along with propylthiouracil in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (28.57) | 18.7374 |
| 1990's | 6 (17.14) | 18.2507 |
| 2000's | 12 (34.29) | 29.6817 |
| 2010's | 6 (17.14) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Aungst, BJ; Shapiro, JR; Vesell, ES | 1 |
| Crile, G; Gilliland, PF; Ibarra, JD; Peake, RL; Petty, FC; Roberts, JW | 1 |
| Boddaert, A; Chevrier, M; Cordier, A; De Sandro, V; Melcion, C; Richert, L | 1 |
| Kariya, K; Lee, E; Okuno, S | 1 |
| Hom, FS; Miskel, JJ | 1 |
| Myant, NB | 1 |
| Oppenheimer, JH | 1 |
| Japundzić, MM; Kulić-Japundzić, IP | 1 |
| Appenzeller, O; Heffron, WA | 1 |
| Bettman, JW; Daroff, RB; Hoyt, WF; Sanders, MD | 1 |
| Rivlin, RS; Wagner, HN | 1 |
| Blacker, KL; Boyer, TD; Lee, KH; Vessey, DA | 1 |
| Mitsumori, K; Onodera, H; Shimo, T; Takahashi, M; Takegawa, K; Yasuhara, K | 1 |
| Grüters, A; Hüfner, M; Lakomek, M; Roth, C; Siggelkow, H | 1 |
| Hood, A; Klaassen, CD; Liu, J | 1 |
| Cook, JC; Davis, LG; Frame, SR; O'Connor, JC | 1 |
| Kajimura, T; Nomura, M; Ohno, H; Satoh, H; Sugawara, T; Tsuchiya, Y | 1 |
| Carney, EW; Crissman, JW; Marty, MS | 1 |
| Frame, SR; Ladics, GS; O'Connor, JC | 1 |
| Kawamura, S; Kunimatsu, T; Mikami, N; Miyata, K; Okuno, Y; Seki, T; Sukata, T; Yabushita, S; Yamada, T | 1 |
| Moore, DD; Qatanani, M; Zhang, J | 1 |
| Connor, JO; Delker, DA; Everds, NE; Frame, SR; Glatt, CM; Green, JW; Ouyang, M; Poindexter, G; Snajdr, S; Welsh, W | 1 |
| Coelho-Palermo Cunha, G; van Ravenzwaay, B | 1 |
| Cunha, GC; Leibold, E; Looser, R; Mellert, W; Prokoudine, A; van Ravenzwaay, B; Walk, T; Wiemer, J | 1 |
| Fukuda, T; Ohara, A; Sumida, K; Suzuki, N; Yamada, F | 1 |
| Aoyama, H; Fukuda, T; Hojo, H; Iwashita, K; Kosaka, T; Minami, K; Ogata, K; Sato, A; Suto, H; Takahashi, N; Tomiyama, N; Yamada, T | 1 |
2 review(s) available for phenobarbital and propylthiouracil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Effects of drugs on the metabolism of bile acids.
Topics: Animals; Bile Acids and Salts; Biological Transport; Biological Transport, Active; Carbon Radioisotopes; Chenodeoxycholic Acid; Cholesterol; Cholestyramine Resin; Cholic Acids; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Humans; Hydroxycholesterols; Ileum; Intestinal Mucosa; Liver; Liver Circulation; Mixed Function Oxygenases; Phenobarbital; Propylthiouracil; Rats; Sulfathiazoles; Taurine; Thyroid Gland; Thyroxine; Triiodothyronine; Vitamins | 1972 |
33 other study(ies) available for phenobarbital and propylthiouracil
| Article | Year |
|---|---|
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Unusual characteristics of the dose-dependent uptake of propylthiouracil by thyroid gland in vivo. Effects of thyrotropin, iodide or phenobarbital pretreatment.
Topics: Animals; Dose-Response Relationship, Drug; Iodides; Kinetics; Male; Phenobarbital; Propylthiouracil; Rats; Thyroid Gland; Thyrotropin; Time Factors | 1979 |
Treatment of hyperthyroidism. Panel discussion.
Topics: Adolescent; Adult; Child; Female; Guanethidine; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Methimazole; Phenobarbital; Propranolol; Propylthiouracil; Reserpine; Thyroidectomy | 1975 |
Comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal T4 metabolism and thyroid gland function in rats.
Topics: Amiodarone; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochromes b5; Glucuronosyltransferase; Kidney; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Phenytoin; Propylthiouracil; Rats; Rats, Inbred Strains; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1991 |
Induction of anionic glutathione transferases in rat liver by propylthiouracil.
Topics: Animals; Chromatography, DEAE-Cellulose; Cytosol; Enzyme Induction; Glutathione Transferase; In Vitro Techniques; Liver; Male; Phenobarbital; Propylthiouracil; Rats; Rats, Inbred Strains | 1987 |
Oral dosage form design and its influence on dissolution rates for a series of drugs.
Topics: Administration, Oral; Capsules; Dicumarol; Diethylstilbestrol; Digitoxin; Dosage Forms; Drug Compounding; Ethinyl Estradiol; Gastric Juice; Hydrocortisone; Phenobarbital; Phenylbutazone; Propylthiouracil; Reserpine; Solubility; Spectrophotometry; Sulfadiazine; Surface-Active Agents; Tablets; Time Factors; Ultraviolet Rays | 1970 |
Thyroid hormones in liver.
Topics: Binding Sites; Humans; Liver; Phenobarbital; Propylthiouracil; Thyroid Hormones | 1972 |
The stimulation of compensatory adrenal growth in rats by phenobarbital and propylthiouracil.
Topics: Adrenal Glands; Adrenalectomy; Animals; Phenobarbital; Pituitary Gland; Propylthiouracil; Rats | 1970 |
Choreoathetosis in hyperthyroidism: a manifestation of a hyperadrenergic state.
Topics: Adult; Chorea; Female; Humans; Hyperthyroidism; Phenobarbital; Prednisone; Propranolol; Propylthiouracil; Sympathetic Nervous System | 1970 |
Edema of the optic disc in hyperthyroidism without exophathalmos. A fluorescein angiographic study of its resolution.
Topics: Adolescent; Cerebrospinal Fluid; Exophthalmos; Female; Fluoresceins; Fluoroscopy; Fundus Oculi; Humans; Hyperthyroidism; Ophthalmoscopy; Papilledema; Phenobarbital; Photography; Pressure; Propylthiouracil | 1968 |
Anemia in hyperthyroidism.
Topics: Adolescent; Adult; Aged; Anemia; Erythrocyte Aging; Female; Humans; Hyperthyroidism; Iron; Male; Middle Aged; Phenobarbital; Propylthiouracil; Reserpine | 1969 |
Effect of inducers on the activity of glutathione S-transferase and other enzymes of the glutathione pathway in cultured human keratinocytes.
Topics: Butylated Hydroxyanisole; Cells, Cultured; Enzyme Induction; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Humans; Keratinocytes; Phenobarbital; Propylthiouracil; Stilbenes | 1993 |
[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].
Topics: Animals; Antithyroid Agents; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nitrosamines; Phenobarbital; Propylthiouracil; Rats; Rats, Inbred F344; Sulfadimethoxine; Thiocyanates | 1996 |
[Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism].
Topics: Adrenergic beta-Antagonists; Adult; Antithyroid Agents; Autoantibodies; Developmental Disabilities; Diseases in Twins; Female; Fetal Blood; Graves Disease; Humans; Hypnotics and Sedatives; Infant, Newborn; Infectious Disease Transmission, Vertical; Iodide Peroxidase; Microcephaly; Phenobarbital; Pregnancy; Pregnancy Complications; Propranolol; Propylthiouracil; Receptors, Thyrotropin; Thyroxine; Triiodothyronine; Twins, Dizygotic | 1997 |
Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation.
Topics: Animals; Antithyroid Agents; Cell Division; Enzyme Induction; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Propylthiouracil; Random Allocation; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones; Thyrotropin; Time Factors | 1999 |
Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure.
Topics: Animals; Antithyroid Agents; Body Fluids; Body Weight; Cell Division; Epithelial Cells; Estrus; Female; Glucuronosyltransferase; Gonadotropins, Pituitary; Iodide Peroxidase; Liver; Male; Microsomes, Liver; Ovariectomy; Phenobarbital; Propylthiouracil; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Thyroid Gland; Thyroid Hormones; Toxicity Tests; Uterus | 1999 |
Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats.
Topics: Animals; Calcium Channel Blockers; Female; Glucuronosyltransferase; Hyperplasia; Hypertrophy; Liver; Microsomes, Liver; Nicardipine; Phenobarbital; Propylthiouracil; Rats; Rats, Wistar; Thiazoles; Thyroid Diseases; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 2000 |
Evaluation of the male pubertal assay's ability to detect thyroid inhibitors and dopaminergic agents.
Topics: Animals; Antithyroid Agents; Body Weight; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Genitalia, Male; Haloperidol; Liver; Male; Organ Size; Phenobarbital; Propylthiouracil; Rats; Rats, Sprague-Dawley; Sexual Maturation; Thyroid Gland; Thyrotropin; Thyroxine | 2001 |
Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators.
Topics: Androgens; Animals; Antibody Formation; Antithyroid Agents; Aromatase Inhibitors; Body Weight; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Hormones; Injections, Intraperitoneal; Ketoconazole; Male; Organ Size; Phenobarbital; Propylthiouracil; Rats; Rats, Sprague-Dawley; Spleen; Steroids; Thyroid Gland | 2002 |
Enhanced rat Hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators.
Topics: Administration, Oral; Androgen Antagonists; Animals; Antithyroid Agents; Body Weight; Castration; Dichlorodiphenyl Dichloroethylene; Drug Evaluation, Preclinical; Eating; Injections, Subcutaneous; Male; Organ Size; Phenobarbital; Propylthiouracil; Rats; Rats, Inbred Strains; Reproducibility of Results; Testosterone Propionate; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 2004 |
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.
Topics: Animals; Anticonvulsants; Blotting, Northern; Cell Proliferation; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Male; Mice; Models, Biological; Mutation; Phenobarbital; Proliferating Cell Nuclear Antigen; Propylthiouracil; Pyridines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Transcription Factors; Triiodothyronine; Xenobiotics | 2005 |
Molecular characterization of thyroid toxicity: anchoring gene expression profiles to biochemical and pathologic end points.
Topics: Animals; Antithyroid Agents; Gene Expression Profiling; Glucuronosyltransferase; Iodide Peroxidase; Iodides; Liver; Male; Organ Size; Phenobarbital; Propylthiouracil; Rats; Thyroid Gland; Thyroid Hormones | 2005 |
Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats.
Topics: Animals; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Hyperplasia; Hypertrophy; Iodine Radioisotopes; Male; Perchlorates; Phenobarbital; Potassium Compounds; Potassium Iodide; Propylthiouracil; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Toxicity Tests; Triiodothyronine | 2007 |
The use of metabolomics for the discovery of new biomarkers of effect.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Androgen Antagonists; Animals; Antithyroid Agents; Biomarkers; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Female; Flutamide; Gas Chromatography-Mass Spectrometry; Herbicides; Liver; Male; Metabolic Networks and Pathways; Phenobarbital; Propylthiouracil; Rats; Rats, Wistar; Reproducibility of Results; Sex Factors; Systems Biology; Tandem Mass Spectrometry; Time Factors; Toxicology; Tyrosine | 2007 |
Specific alteration of gene expression profile in rats by treatment with thyroid toxicants that inhibit thyroid hormone synthesis.
Topics: Animals; Antithyroid Agents; Enzyme Induction; Gene Expression Profiling; Iodide Peroxidase; Liver; Male; Methimazole; Microarray Analysis; Phenobarbital; Propylthiouracil; Rats, Wistar; Thyroid Gland; Thyroid Hormones; Transcriptome | 2018 |
Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high dose.
Topics: Animals; Brain; Feasibility Studies; Female; Phenobarbital; Propylthiouracil; Rats; Sodium; Thyroid Gland; Thyroid Hormones | 2023 |