phenobarbital has been researched along with pregnenolone carbonitrile in 143 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 81 (56.64) | 18.7374 |
| 1990's | 32 (22.38) | 18.2507 |
| 2000's | 24 (16.78) | 29.6817 |
| 2010's | 5 (3.50) | 24.3611 |
| 2020's | 1 (0.70) | 2.80 |
| Authors | Studies |
|---|---|
| Anisfeld, AM; Edwards, PA; Goodwin, B; Jones, SA; Kast, HR; Kliewer, S; Stoltz, CM; Tarr, PT; Tontonoz, P; Willson, TM | 1 |
| Choudhuri, S; Guo, GL; Klaassen, CD | 1 |
| Habeebu, SS; Johnson, DR; Klaassen, CD | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 1 |
| Selye, H; Taché, J; Taché, Y | 1 |
| Boobis, AR; Nebert, DW; Pelkonen, O | 1 |
| Cameron, RG; Farber, E; Griffin, MJ; Joly, JG; Murray, RK; Sharma, RN | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Eaton, DL; Klaassen, CD | 1 |
| Da Silva, OM; Kourounakis, P; Lykissas, ED | 1 |
| Garg, BD; Kourounakis, P; Tuchweber, B | 1 |
| Bjondahl, K | 1 |
| Gielen, JE; Kremers, P; Pasleau, F | 1 |
| Baird, MB; Birnbaum, LS; Massie, HR | 1 |
| Garg, BD; Kourounakis, P; Kovacs, K; Szabo, S; Tuchweber, B | 1 |
| Dybing, E; Mitchell, JR; Nelson, SD; Sasame, HA | 1 |
| Garg, BD; Salas, M; Tuchweber, B | 1 |
| Salas, M; Tuchweber, B | 1 |
| Klaassen, CD | 5 |
| Bartsch, H; Malaveille, C; Montesano, R | 1 |
| Paumgartner, G; Schwarz, HP; von Bergmann, K | 2 |
| Alexandrov, K; Frayssinet, C | 1 |
| Drew, RT; Fouts, JR; Lo, RJ; Roth, RP | 1 |
| Arcos, JC; Argus, MF; Bryant, GM; Buu-Hoi, NP; Valle, RT | 1 |
| Gangolli, SD; Lake, BG; Lloyd, AG; Longland, RC | 1 |
| Buhler, DR; McCrary, JA; Novak, RF; Primiano, T; Springer, DL; Zangar, RC | 1 |
| Nakanishi, S; Nishiguchi, K; Serasinghe, P; Serasinghe, S; Yamazaki, H | 1 |
| Chen, S; Li, D; Moorthy, B; Randerath, K | 1 |
| Lutz, W | 1 |
| Watkins, JB | 1 |
| Baker, MT; Chiang, CK; Vasquez, MT | 1 |
| Bellward, GD; Chang, T; Levine, M | 1 |
| Kelley, M; Safe, S; Womack, J | 1 |
| Cresteil, T; Marie, S | 1 |
| De Vries, J; Groot, EJ; van Bree, L | 1 |
| Delaforge, M; Doignon, JL; Grognet, JM; Rivière, R; Sartori, E | 1 |
| Gerstner, E; Heubel, F; Reuter, T | 1 |
| Bloom, SE; Friedman, FK; Gelboin, HV; Lorr, NA; Miller, H; Park, SS | 1 |
| Gregus, Z; Klaassen, CD; Madhu, C | 1 |
| Koliada, AIu | 1 |
| Kammerer, RC; Lampe, MA | 1 |
| Bartsch, H; Béréziat, JC; Brun, G; Friedman, FK; Gelboin, HV; Hietanen, E; Malaveille, C; Park, SS | 1 |
| Gram, TE; Okine, LK | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Burke, MD; Elcombe, CR; Haaparanta, T; Halpert, J; Mayer, RT; Thompson, S | 1 |
| Klaassen, CD; Thompson, TN | 2 |
| Arlotto, MP; Gorski, JR; Klaassen, CD; Parkinson, A | 1 |
| Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ | 1 |
| Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET | 1 |
| Gregus, Z; Varga, F | 1 |
| Mécs, I; Selye, H; Szabo, S | 1 |
| Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Hildebrandt, AG; Roots, I; Speck, M | 1 |
| Kourounakis, P; Selye, H; Szabo, S | 1 |
| Solymoss, B; Zsigmond, G | 2 |
| Kourounakis, P; Tuchweber, B; Werringloer, J | 1 |
| Glaumann, H; Lindeborg, T | 1 |
| Gustafsson, JA; Ingelman-Sundberg, M | 1 |
| Beaulieu, T; Jago, MV; Kovacs, K; Tuchweber, B | 1 |
| Stohs, SJ; Talcott, RE | 1 |
| Mason, JI; Schacter, BA | 1 |
| Bagrel, D; Ratanasavanh, D; Siest, G | 1 |
| Edwards, AM | 1 |
| Nebert, DW; Negishi, M | 1 |
| Cudak, C; Garland, H; Hyatt, B; Leavitt, S; Montgomery, L; Nesnow, S; Vaughan, TO | 1 |
| Davis, M; Smith, HM; Tredger, JM; Williams, R | 1 |
| Parkinson, A; Robertson, LW; Safe, SH | 1 |
| Bradshaw, JJ; Ivanetich, KM | 1 |
| Bellward, GD; Gontovnick, LS; Sunahara, G | 1 |
| Mannering, GJ; Robbins, MS | 1 |
| Dannan, GA; Guengerich, FP; Kaminsky, LS | 1 |
| Elshourbagy, NA; Guzelian, PS | 1 |
| Gustafsson, JA; Hansson, T; Rafter, J | 1 |
| Förlin, L | 1 |
| Baron, J; Greenspan, P; Kapke, GF; Redick, JA; Taira, Y | 1 |
| Davis, M; Powell-Jackson, PR; Smith, HM; Tredger, JM; Williams, R | 1 |
| Batt, AM; Martin, N; Siest, G | 1 |
| Steggles, AW; Vlasuk, GP; Walz, FG | 1 |
| Guzelian, PS; Newman, SL | 1 |
| Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
| Duvivier, J; Gielen, JE; Van Cantfort, J | 1 |
| Porter, WR; Trager, WF; Wheeler, C | 1 |
| Bridges, JW; Fennell, TR; Sweatman, BC | 1 |
| Goerz, G; Ruzicka, T; Vizethum, W | 1 |
| Baird, MB | 1 |
| Costa, AK; Ivanetich, KM | 1 |
| Kourounakis, PN; Tani, E | 1 |
| Ioannides, C; Irizar, A | 1 |
| Barter, RA; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Caldwell, J; Thatcher, NJ | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Paine, AJ; Wright, MC | 1 |
| Barter, RA; Klaassen, CD | 1 |
| Cresteil, T; Gonzalez, FJ; Kersual, J; Marie, S; Sonnier, M | 1 |
| Guengerich, FP; Horie, T; Kitada, M; Kiuchi, M; Ohmori, S | 1 |
| Kharasch, ED; Thummel, KE | 1 |
| Chabot, GG; Hanstein, WG; Mahnke, A; Roos, PH | 1 |
| Dehal, SS; Kupfer, D | 1 |
| Abbott, FS; Huang, HS; Jurima-Romet, M; Tang, W; Whitehouse, LW | 1 |
| Konishi, H; Morita, K; Yamaji, A | 1 |
| Moorthy, B; Randerath, E; Randerath, K; Sriram, P | 1 |
| Chen, ZY; Eaton, DL; He, CY; Liu, YF; White, CC | 1 |
| Amacher, DE; Schomaker, SJ | 1 |
| Klaassen, CD; Kolaja, KL | 1 |
| Carmichael, N; Debruyne, E; Lassere, D; Nicod, L; Richert, L; Viollon-Abadie, C | 1 |
| Fujita, S; Funae, Y; Imaoka, S; Kazusaka, A; Maeda, Y; Masuda, M; Morita, K | 1 |
| Hood, AM; Klaassen, CD; Kolaja, KL | 1 |
| Hood, A; Klaassen, CD; Liu, J | 1 |
| Hashmi, R; Hood, A; Klaassen, CD | 1 |
| Law, MY; Moody, DE; Slawson, MH | 1 |
| Engelken, DT; Klaassen, CD; Kolaja, KL | 1 |
| Endo, Y; Honma, R; Jarukamjorn, K; Kuroiwa, M; Nemoto, N; Ohara, A; Sakuma, T; Takai, M | 1 |
| Hood, A; Klaassen, CD | 1 |
| Edwards, AM; Lee, CH | 1 |
| Hartley, DP; Klaassen, CD; Meier, PJ; Rausch-Derra, LC | 1 |
| Johnson, DR; Klaassen, CD | 1 |
| Danz, M; Glöckner, R; Lupp, A; Müller, D; Steinmetzer, P | 1 |
| Bertholet, V; Chandelier, N; de Longueville, F; Evrard, S; Le Bourdellès, B; Meneses-Lorente, G; Pike, A; Rasson, JP; Remacle, J; Surry, D; Talbot, V; Worboys, P | 1 |
| Allen, ML; Hood, A; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Lake, BG; Meredith, C; Price, RJ; Renwick, AB; Scott, MP | 1 |
| Danz, M; Lupp, A; Müller, D | 1 |
| Baba, Y; Doi, K; Ejiri, N; Katayama, K; Kiyosawa, N | 2 |
| Kon, J; Mitaka, T; Miyamoto, S; Ninomiya, S; Ooe, H; Ozone, Y | 1 |
| Ferguson, SS; Goldstein, JA; Jackson, JP; Negishi, M | 1 |
| Bhaskaran, V; Foster, WR; Lehman-McKeeman, LD; Nelson, DM | 1 |
| Back, DJ; Martin, P; Owen, A; Riley, R | 1 |
| Etzrodt, J; Glöckner, R; Lupp, A; Müller, D | 1 |
| Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER | 1 |
| Argikar, UA; Larson, EE; Remmel, RP; Senekeo-Effenberger, K; Tukey, RH | 1 |
| Goldstein, JA; Kamino, H; Konno, Y; Lih, F; Moore, R; Negishi, M; Tomer, KB; Zeldin, DC | 1 |
| Benoki, S; Kodama, S; Miyata, M; Numakura, Y; Shizu, R; Yamazoe, Y; Yoshinari, K | 1 |
| Bainy, AC; Goldstone, JV; Kubota, A; Stegeman, JJ; Woodin, BR | 1 |
| Chatham, LR; Elcombe, CR; Foster, JR; Haines, C; Lake, BG; Vardy, A | 2 |
| Hosaka, T; Ishimura, M; Kakizaki, S; Nobusawa, S; Sasaki, T; Shizu, R; Yoshinari, K | 1 |
4 review(s) available for phenobarbital and pregnenolone carbonitrile
| Article | Year |
|---|---|
[Expression of cytochrome P-450 genes].
Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Liver; Methylcholanthrene; Mice; Oxidation-Reduction; Phenobarbital; Pituitary Hormones, Anterior; Pregnenolone Carbonitrile; Transcription, Genetic | 1992 |
Effects of steroids upon the liver ultrastructure.
Topics: Animals; Benzopyrenes; Desoxycorticosterone; Endocrine Glands; Enzyme Induction; Glucocorticoids; Glycogen; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Norpregnenes; Phenobarbital; Pregnenolone Carbonitrile; Protein Biosynthesis; RNA; Spironolactone; Steroids | 1973 |
Influence of three inducers on rabbit gamma-glutamyltransferase.
Topics: Animals; Cell Nucleus; Cytochrome P-450 Enzyme System; Enzyme Induction; gamma-Glutamyltransferase; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rabbits | 1980 |
Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution.
Topics: Animals; Biological Evolution; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Safrole; Species Specificity | 1982 |
139 other study(ies) available for phenobarbital and pregnenolone carbonitrile
| Article | Year |
|---|---|
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
Topics: Animals; Base Sequence; Bile Acids and Salts; Blotting, Northern; Cell Line; Cell Nucleus; Cells, Cultured; Constitutive Androstane Receptor; DNA-Binding Proteins; Drug Resistance, Multiple; Genes, Reporter; Hepatocytes; Humans; Isoxazoles; Ligands; Liver; Membrane Transport Proteins; Mice; Models, Biological; Molecular Sequence Data; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nucleic Acid Hybridization; Phenobarbital; Pregnane X Receptor; Promoter Regions, Genetic; Protein Binding; Protein Transport; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2002 |
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
Topics: Animals; Blotting, Northern; DNA Probes; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ligands; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membranes; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2002 |
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrenes; Bile; Biliary Tract; Carrier Proteins; Drug Interactions; Gene Expression Regulation; Glutathione; Hyperbilirubinemia; Immunohistochemistry; Liver; Male; Membrane Transport Proteins; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfhydryl Compounds | 2002 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
Inhibition of the effects of alfathesin and other steroid anesthetics by catatoxic steroids in rats.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Female; Ketosteroids; Phenobarbital; Phenytoin; Prednisolone; Pregnanediones; Pregnanes; Pregnenes; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Thyroxine; Time Factors | 1975 |
Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice.
Topics: Animals; Benzopyrenes; Cyclohexanes; DNA; Enzyme Induction; Enzyme Inhibitors; Ethanol; Flavonoids; In Vitro Techniques; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Species Specificity | 1979 |
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics.
Topics: 2-Acetylaminofluorene; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Biosynthesis; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Safrole | 1979 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Effects of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes.
Topics: Animals; Biological Transport, Active; Enzyme Induction; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Procainamide; Rats; Taurocholic Acid | 1979 |
Alterations in the hepatic subcellular composition of nucleic acids and proteins in rats treated with pregnenolone-16alpha-carbonitrile, spironolactone or phenobarbital.
Topics: Animals; Cell Nucleus; DNA; Female; Liver; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; RNA; Spironolactone | 1979 |
Fine structural changes in the liver of young and old rats as influenced by microsomal enzyme inducers.
Topics: Aging; Animals; Dexamethasone; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1979 |
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver Injury; Female; Nafenopin; Phenobarbital; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Time Factors; Triglycerides | 1978 |
Is steroid-16alpha-hydroxylase supported by more than one monooxygenase?
Topics: Animals; Female; Flavonoids; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Naphthalenes; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Sex Factors; Steroid Hydroxylases | 1978 |
Pregnenolone-16alpha-carbonitrile-inducible cytochrome P450 in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1976 |
Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.
Topics: Animals; Digitoxin; Drug Interactions; Ethionine; Female; Hexobarbital; In Vitro Techniques; Liver; Microscopy, Electron; Paralysis; Pharmaceutical Preparations; Phenobarbital; Pregnenolone Carbonitrile; Rats; Seizures; Sleep; Zoxazolamine | 1977 |
Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates.
Topics: Aerobiosis; Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Estradiol; Estrogens; Estrone; Ethinyl Estradiol; Hydroxysteroids; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Superoxide Dismutase | 1976 |
Microsomal enzyme inducers and hypervitaminosis A in rats.
Topics: Animals; Bone Diseases; Enzyme Induction; Female; Liver; Microsomes, Liver; Paralysis; Phenobarbital; Phenytoin; Pregnenolone Carbonitrile; Rats; Vitamin A; Zoxazolamine | 1976 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estradiol; Fatty Liver; Female; Golgi Apparatus; Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Triglycerides | 1976 |
Studies on the mechanism of spironolactone protection against indomethacin toxicity.
Topics: Animals; Bile; Depression, Chemical; Enzyme Induction; In Vitro Techniques; Indomethacin; Male; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors | 1976 |
Effect of microsomal enzyme inducers on the biliary excretion of an exogenous load of bilirubin in newborn rats.
Topics: Age Factors; Animals; Animals, Newborn; Bile; Bilirubin; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1976 |
Differential effect of phenobarbitone, pregnenolone-16-a-carbonitrile and adinoacetonitrile on dialkylnitrosamine metabolism and mutagenicity in vitro.
Topics: Acetonitriles; Alkylation; Aminoacetonitrile; Animals; Carbon Dioxide; Carbon Radioisotopes; Cricetinae; Female; Liver; Male; Mice; Nitrosamines; Nucleic Acids; Phenobarbital; Pregnenolone Carbonitrile; Rats; Salmonella typhimurium | 1975 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on bile formation in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Body Weight; Cholesterol; Liver; Male; Organ Size; Phenobarbital; Phospholipids; Pregnenolone Carbonitrile; Rats; Spironolactone; Taurocholic Acid | 1975 |
Aryl and aniline hydroxylases in rat nuclear membranes after pretreatment with pregnenolone 16alpha-carbonitrile, phenobarbital and methylcholanthrene.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cell Nucleus; Enzyme Induction; Liver; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1975 |
Biliary excretion of drugs: role of ligandin in newborn immaturity and in the action of microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Biotransformation; Carrier Proteins; Enzyme Induction; Glutathione Transferase; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Protein Binding; Rats; Sulfobromophthalein; Time Factors | 1975 |
Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.
Topics: Animals; Carbon Tetrachloride; Carboxyhemoglobin; Hemoglobins; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rabbits | 1975 |
Dimethylnitrosamine-demethylase: molecular size-dependence of repression by polynuclear hydrocarbons. Nonhydrocarbon repressors.
Topics: Animals; Dimethylnitrosamine; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Oxidoreductases, N-Demethylating; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Rats | 1976 |
The influence of some foreign compounds on hepatic xenobiotic metabolism and the urinary excretion of D-glucuronic acid metabolites in the rat.
Topics: Animals; Butylated Hydroxytoluene; DDT; Female; Glucuronates; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1976 |
Changes in adult metabolism of aflatoxin B1 in rats neonatally exposed to diethylstilbestrol. Alterations in alpha-class glutathione S-transferases.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Biotransformation; Blotting, Western; Diethylstilbestrol; DNA; Enzyme Induction; Female; Glutathione Transferase; Liver; Male; Phenobarbital; Pregnancy; Pregnenolone Carbonitrile; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1992 |
Intralobular localization of different cytochrome P-450 form dependent monooxygenase activities in the liver of normal and inducer-treated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1992 |
Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Replication; Enzyme Induction; Female; Kidney; Liver; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Thymidine | 1992 |
Effect of microsomal enzyme inducing agents on hepatic biotransformation in cotton rats (Sigmodon hispidus): comparison to that in Sprague-Dawley rats.
Topics: Animals; Arylsulfotransferase; Biotransformation; Cytochrome P-450 Enzyme System; Dinitrochlorobenzene; Enzyme Induction; Ethacrynic Acid; Female; Glucuronosyltransferase; Glutathione Transferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sulfobromophthalein; Sulfotransferases | 1991 |
Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Halothane; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Warfarin | 1991 |
Influence of sex and inducer treatment on the high- and low-affinity forms of hepatic microsomal erythromycin N-demethylase in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Erythromycin; Female; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1990 |
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone | 1990 |
Phenobarbital-inducible gene expression in developing rat liver: relationship to hepatocyte function.
Topics: Animals; Blotting, Northern; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Isoenzymes; Liver; Male; Phenobarbital; Polycyclic Compounds; Pregnancy; Pregnenolone Carbonitrile; Rats; RNA | 1989 |
Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4'-dichlorobiphenyl, phenobarbitone and pregnenolone-16-alpha-carbonitrile.
Topics: Acetaminophen; Animals; Aspirin; Cytochrome P-450 Enzyme System; Enzyme Induction; Gastric Mucosa; Glutathione; In Vitro Techniques; Liver; Male; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Salicylates | 1989 |
Metabolism of dihydroergotamine by a cytochrome P-450 similar to that involved in the metabolism of macrolide antibiotics.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dihydroergotamine; Female; Isoenzymes; Kinetics; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Troleandomycin | 1989 |
Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone.
Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Rifampin; Warfarin | 1989 |
Evidence for a PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbital-inducible forms.
Topics: Animals; Antibodies; Chick Embryo; Chickens; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Phenobarbital; Pregnenolone Carbonitrile | 1989 |
Inducibility of glutathione S-transferases in hamsters.
Topics: Animals; Butylated Hydroxyanisole; Cats; Cricetinae; Dexamethasone; Dogs; Enzyme Induction; Ethanol; Glutathione Transferase; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Quail; Rabbits; Rats; Species Specificity; Stilbenes; Trout | 1989 |
[Cytochrome P-450 isoforms in the liver of rats treated with phenobarbital, 3-methylcholanthrene and Aroclor 1254 studied by monoclonal antibodies].
Topics: Animals; Antibodies, Monoclonal; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clone Cells; Cytochrome P-450 Enzyme System; Imidazoles; Immunization; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1986 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
Monoclonal antibody-directed analysis of cytochrome P-450-dependent monooxygenases and mutagen activation in the livers of DBA/2 and C57BL/6 mice.
Topics: Animals; Antibodies, Monoclonal; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Activation; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Mutagenicity Tests; Phenobarbital; Pregnenolone Carbonitrile; Salmonella typhimurium | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity | 1985 |
Hepatic presystemic elimination of diethylstilbestrol by rats and effect of pretreatment with inducers of UDP-glucuronosyltransferase.
Topics: Animals; Bile; Diethylstilbestrol; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1985 |
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN).
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin | 1985 |
Role of glutathione and hepatic glutathione S-transferase in the biliary excretion of methyl mercury, cadmium and zinc: a study with enzyme inducers and glutathione depletors.
Topics: Animals; Bile; Cadmium; Enzyme Induction; Glutathione; Glutathione Transferase; Liver; Male; Methylmercury Compounds; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Stilbenes; Zinc | 1985 |
Protection by catatoxic steroids against the paralysis caused by combined treatment with thyroxine and methylphenidate.
Topics: Androstenols; Animals; Drug Synergism; Estradiol; Ethylestrenol; Female; Humans; Hydroxysteroids; Hyperkinesis; Ketosteroids; Methylphenidate; Norpregnanes; Paralysis; Phenobarbital; Phenytoin; Prednisolone; Pregnenolone Carbonitrile; Progesterone; Propionates; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Thyroxine | 1972 |
Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction.
Topics: Aminopyrine; Animals; Azides; Catalase; Cytochrome P-450 Enzyme System; Hemeproteins; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1973 |
Effect of pharmacologic conditioning on sulfadiazine toxicity and concentrations in plasma.
Topics: Adrenocorticotropic Hormone; Androstenols; Animals; Depression, Chemical; Desoxycorticosterone; Estradiol; Female; Ketosteroids; Kidney; Organ Size; Phenobarbital; Prednisolone; Pregnanediones; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Stimulation, Chemical; Sulfadiazine; Thyroxine; Triamcinolone | 1974 |
Effect of microsomal enzyme inducers on the liver changes produced by common bile-duct ligature.
Topics: Animals; Bilirubin; Common Bile Duct; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Female; Glucuronosyltransferase; Hepatomegaly; Ligation; Liver; Liver Cirrhosis, Biliary; Microsomes, Liver; NADH, NADPH Oxidoreductases; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1974 |
Proceedings: Increased cholesterol saturation in rat bile induced by spironolactone and pregnenolone-16alpha-carbonitrile.
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Male; Phenobarbital; Phospholipids; Pregnenolone Carbonitrile; Rats; Spironolactone | 1974 |
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Induction; Female; Hexobarbital; Liver; Microscopy, Electron; Microsomes, Liver; Morphinans; NAD; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; Serum Albumin, Bovine; Time Factors | 1974 |
Effect of a catatoxic steroid pregnenolone-16alpha-carbonitrile, on rat liver microsomal subfractions.
Topics: Adenosine Triphosphatases; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Cycloheximide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dose-Response Relationship, Drug; Female; Glucose-6-Phosphatase; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nucleosides; Phenobarbital; Phospholipids; Phosphoric Monoester Hydrolases; Pregnenolone Carbonitrile; Proteins; Rats | 1974 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine | 1974 |
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Enzyme Induction; Liver; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium | 1974 |
Effect of various steroids on the hepatic glucuronidation and biliary excretion of bilirubin.
Topics: Animals; Bile; Bile Pigments; Bilirubin; Body Weight; Female; Glucuronates; Hexosyltransferases; Hydrocortisone; Kinetics; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1973 |
Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics.
Topics: Age Factors; Androstanes; Animals; Carbon Monoxide; Carbon Radioisotopes; Castration; Estradiol; Female; Hydroxysteroids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Sex Factors; Steroid Hydroxylases; Sulfuric Acids; Testosterone | 1974 |
Effect of steroidal and nonsteroidal microsomal enzyme inducers on the hepatotoxicity of pyrrolizidine alkaloids in rats.
Topics: Animals; Enzyme Induction; Ethylestrenol; Female; Hepatectomy; Kidney; Liver; Lung; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Pregnenolone Carbonitrile; Prodigiosin; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Spironolactone | 1974 |
Enzyme induction with pregnenolone-16 alpha-carbonitrile--onset of action and effect of thioacetamide.
Topics: Acetamides; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Thioacetamide; Time Factors | 1974 |
The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Heme; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Spleen; Time Factors | 1974 |
Relationship between inductions of monooxygenase activity and gamma-glutamyltranspeptidase in rat hepatocyte primary cultures.
Topics: Animals; Bucladesine; Cells, Cultured; Cycloheximide; Dexamethasone; gamma-Glutamyltransferase; Kinetics; Liver; Male; Mixed Function Oxygenases; Niacinamide; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1984 |
Identification of cocarcinogens and their potential mechanisms of action using C3H10T 1/2 CL8 mouse embryo fibroblasts.
Topics: Animals; Aroclors; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; Enzyme Induction; Mice; Mice, Inbred C3H; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile | 1981 |
Use of a direct high performance liquid chromatography method for multiple testosterone hydroxylations in studies of microsomal monooxygenase activities.
Topics: Acetanilides; Aldrin; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Ethylmorphine; Male; Mesocricetus; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; Testosterone | 1984 |
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1983 |
Isoflurane: a comparison of its metabolism by human and rat hepatic cytochrome P-450.
Topics: Adult; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Female; Fluorine; Humans; In Vitro Techniques; Isoflurane; Male; Microsomes, Liver; Middle Aged; Phenobarbital; Pregnenolone Carbonitrile; Rats; Species Specificity | 1984 |
Nonadditive effects of combined in vivo hepatic microsomal enzyme inducers in the Wistar rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Stilbenes | 1983 |
Effects of the interferon inducing agents tilorone and polyriboinosinic acid . polyribocytidylic acid (poly IC) on the hepatic monooxygenase systems of pregnant and fetal rats.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fetus; Fluorenes; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Oxygenases; Phenobarbital; Poly I-C; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Tilorone | 1984 |
Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450).
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Catalysis; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunochemistry; Immunoelectrophoresis; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1984 |
Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Immunoassay; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Peptide Fragments; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Effects of some common inducers on the hepatic microsomal metabolism of androstenedione in rainbow trout with special reference to cytochrome P-450-dependent enzymes.
Topics: Androstenedione; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Salmonidae; Trout | 1980 |
Effects of clophen A50, 3-methylcholanthrene, pregnenolone-16 alpha-carbonitrile, and phenobarbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout, Salmo gairdneri, of different age and sex.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Salmonidae; Sex Factors; Trout | 1980 |
Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule.
Topics: Animals; Fluorescent Antibody Technique; Liver; Male; Methylcholanthrene; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Effect of rifampicin on the mouse hepatic mixed-function oxidase system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rifampin; Sodium Fluoride | 1981 |
Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Safrole; Substrate Specificity | 1981 |
Species differences in cytochromes P-450 and epoxide hydrolase: comparisons of xenobiotic-induced hepatic microsomal polypeptides in hamsters and rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Species Specificity; Stilbenes | 1983 |
Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation.
Topics: Aldrin; Animals; Cytochrome P-450 Enzyme System; Epoxy Compounds; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
The influence of five monoxygenase inducers on liver cytosol estradiol receptor levels in the ovariectomized adult rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Castration; Cytosol; Enzyme Induction; Female; Liver; Methylcholanthrene; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Receptors, Estradiol; Receptors, Estrogen | 1981 |
Changes in the metabolic profiles of R- and S-warfarin and R- and S-phenprocoumon as a probe to categorize the effect of inducing agents on microsomal hydroxylases.
Topics: 4-Hydroxycoumarins; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenprocoumon; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Stereoisomerism; Warfarin | 1981 |
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole | 1980 |
Inducibility of drug-metabolizing enzymes in the rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rifampin; Skin | 1980 |
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P-450 system.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Tetrachloroethylene | 1980 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on rat hepatic beta-glucuronidase.
Topics: Animals; Female; Glucuronidase; Liver; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Spironolactone | 1995 |
Expression and inducibility of cytochrome P450 proteins belonging to families 2,3 and 4 in the rabbit aorta.
Topics: Animals; Aorta; Arteriosclerosis; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Male; Microsomes; Phenobarbital; Pregnenolone Carbonitrile; Rabbits | 1995 |
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Enzyme Induction; Glucuronosyltransferase; Homeostasis; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1995 |
Origins of hepatomegaly produced by dexamethasone (DEX), pregnenolone 16 alpha-carbonitrile (PCN) and phenobarbitone (PB) in female Sprague-Dawley rats.
Topics: Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Hepatomegaly; Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley | 1994 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Dexamethasone; Enzyme Induction; Humans; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Troleandomycin | 1994 |
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats.
Topics: Administration, Oral; Animals; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1994 |
Evidence for the transient expression of P-450 during the neonatal period in rat.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Kidney; Liver; Lung; Male; Microsomes, Liver; Molecular Sequence Data; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley | 1994 |
Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys.
Topics: Amino Acid Sequence; Animals; Cytochrome P-450 Enzyme System; Humans; Macaca fascicularis; Male; Microsomes, Liver; Molecular Sequence Data; Phenobarbital; Pregnenolone Carbonitrile; Saimiri; Substrate Specificity | 1993 |
Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?
Topics: Alfentanil; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Pyrazoles; Rats; Rats, Sprague-Dawley | 1993 |
In vivo induction of cytochrome P450 CYP3A expression in rat leukocytes using various inducers.
Topics: Animals; Blotting, Western; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Leukocytes; Liver; Male; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Sprague-Dawley | 1996 |
Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.
Topics: Animals; Antineoplastic Agents, Hormonal; Biotransformation; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cytochrome P-450 Enzyme System; Female; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tamoxifen | 1996 |
Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
Topics: Analysis of Variance; Animals; Anticonvulsants; Ascorbic Acid; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Glutathione; Homeostasis; L-Lactate Dehydrogenase; Liver; Male; Mass Spectrometry; Methionine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Valproic Acid; Vitamin E | 1996 |
Involvement of CYP2E in 8-hydroxylation of theophylline in mouse hepatic microsomes-difference from its N-demethylations.
Topics: Acetone; Aminoacetonitrile; Aminopyrine; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fomepizole; Hydroxylation; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Nitrophenols; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Pyrazoles; Theophylline | 1996 |
The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats.
Topics: Animals; Bile; Biliary Tract; Enzyme Induction; Femoral Vein; Injections, Intravenous; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Ouabain; Phenobarbital; Portal Vein; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley | 1995 |
Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo.
Topics: Animals; Cytochrome P-450 Enzyme System; DNA Adducts; Enzyme Induction; Estrogen Antagonists; Female; Mice; Mice, Inbred ICR; Phenobarbital; Pregnenolone Carbonitrile; Tamoxifen | 1997 |
Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens.
Topics: Animals; Blotting, Northern; Bromodeoxyuridine; Carcinogens; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; DNA; Fibric Acids; Gene Expression Regulation, Enzymologic; Liver; Male; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; RNA, Messenger | 1995 |
Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biomarkers; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Ethylmorphine-N-Demethylase; Female; Isoniazid; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sex Factors | 1998 |
Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis.
Topics: Animals; Apoptosis; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Enzyme Induction; Glucuronosyltransferase; Immunohistochemistry; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Transforming Growth Factor beta | 1998 |
Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice.
Topics: Animals; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Liver; Male; Mice; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1999 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid | 1998 |
The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16alpha-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-beta1 expression.
Topics: Animals; Apoptosis; Enzyme Induction; Glucuronosyltransferase; Hyperplasia; Male; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Transforming Growth Factor beta | 1999 |
Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation.
Topics: Animals; Antithyroid Agents; Cell Division; Enzyme Induction; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Propylthiouracil; Random Allocation; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones; Thyrotropin; Time Factors | 1999 |
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Topics: Animals; Cell Count; Cell Division; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Hyperplasia; Hypertrophy; Male; Methylcholanthrene; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1999 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |
Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens.
Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Division; Chlorodiphenyl (54% Chlorine); Dextrans; Fluorescent Dyes; Gap Junctions; Image Processing, Computer-Assisted; Immunohistochemistry; Isoquinolines; Liver; Male; Methylcholanthrene; Microscopy, Fluorescence; Phenobarbital; Pregnenolone Carbonitrile; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Rhodamines; Signal Transduction; Specific Pathogen-Free Organisms | 2000 |
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Castration; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Liver; Male; Membrane Proteins; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; RNA, Messenger; Sex Characteristics; Sexual Maturation; Testosterone | 2000 |
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
Topics: Animals; Chlorodiphenyl (54% Chlorine); Detergents; Enzyme Induction; Glucuronides; Glucuronosyltransferase; In Vitro Techniques; Iodine Radioisotopes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroxine; Triiodothyronine | 2000 |
Stimulation of DNA synthesis by tumor promoters in primary rat hepatocytes is not mediated by arachidonic acid metabolites.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Division; Cells, Cultured; DDT; Dinoprostone; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Hexachlorocyclohexane; Hypnotics and Sedatives; Male; Phenobarbital; Pregnenolone Carbonitrile; Prostaglandins; Rats; Rats, Wistar; Tritium | 2001 |
Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.
Topics: Animals; Anion Transport Proteins; Carrier Proteins; Enzyme Induction; Liver; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; Organic Anion Transporters, Sodium-Independent; Phenobarbital; Pregnenolone Carbonitrile; Rats; RNA, Messenger; Time Factors | 2001 |
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Topics: Animals; Bile; Disease Models, Animal; Drug Resistance, Multiple; Enzyme Induction; Hyperbilirubinemia; Male; Membrane Transport Proteins; Microsomes, Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Sulfobromophthalein | 2002 |
In vitro induction of cytochrome P450 2B1- and 3A1-mRNA and enzyme immunostaining in cryopreserved precision-cut rat liver slices.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cryopreservation; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunohistochemistry; In Vitro Techniques; Liver; Male; Microtomy; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; RNA, Messenger | 2002 |
Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray.
Topics: Animals; Biotinylation; Female; Gene Expression; Gene Expression Profiling; Liver; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 2002 |
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers.
Topics: Administration, Oral; Animals; Cell Division; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Thyroid Gland; Thyrotropin | 2003 |
Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices.
Topics: Animals; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Culture Techniques; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Enzyme Induction; Isoenzymes; Liver; Male; Oligonucleotide Probes; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Histomorphological changes and cytochrome P450 isoforms expression and activities in precision-cut liver slices from neonatal rats.
Topics: Animals; Animals, Newborn; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Female; Hepatocytes; Histocytochemistry; Isoenzymes; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats | 2005 |
Microarray analysis on CYPs expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile and phenobarbital.
Topics: Animals; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; DNA Primers; Enzyme Induction; Female; Fetus; Injections, Intraperitoneal; Isoenzymes; Liver; Phenobarbital; Placenta; Pregnancy; Pregnenolone Carbonitrile; Protein Array Analysis; Rats; Rats, Inbred F344; RNA, Messenger | 2005 |
Microarray analysis on Phase II drug metabolizing enzymes expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile or phenobarbital.
Topics: Animals; Enzyme Induction; Female; Glucuronosyltransferase; Glutathione Transferase; Injections, Intraperitoneal; Isoenzymes; Liver; Metabolic Detoxication, Phase II; Oligonucleotide Array Sequence Analysis; Phenobarbital; Placenta; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344 | 2005 |
Cytochrome p450 expression of cultured rat small hepatocytes after long-term cryopreservation.
Topics: Animals; Carbon Radioisotopes; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Chromatography, High Pressure Liquid; Collagen; Cryopreservation; Cytochrome P-450 Enzyme System; Drug Combinations; Ethanol; Hepatocytes; Immunoblotting; Isoenzymes; L-Serine Dehydratase; Laminin; Liver; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Proteoglycans; Rats; Rats, Inbred F344; Testosterone; Time Factors | 2006 |
Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.
Topics: Animals; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Liver; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Phenobarbital; Phenytoin; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Transcription Factors | 2006 |
p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.
Topics: Administration, Oral; Animals; Enzyme Induction; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Liver; Male; Mice; Oligonucleotide Array Sequence Analysis; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Mas; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Suppressor Protein p53 | 2006 |
Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Culture Techniques; Cells, Cultured; Chenodeoxycholic Acid; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Induction; Epithelial Cells; Hepatocytes; Humans; Intestinal Mucosa; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Research Design; Rifampin; RNA, Messenger; Transcription Factors; Up-Regulation | 2008 |
Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.
Topics: Aging; Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Enzyme Inhibitors; Hydroxylation; Liver; Male; Mixed Function Oxygenases; Organ Culture Techniques; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Testosterone; Time Factors | 2008 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors | 2009 |
Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Enzyme Induction; Female; GABA Modulators; Gas Chromatography-Mass Spectrometry; Glucuronosyltransferase; Hepatocytes; Humans; Kinetics; Lamotrigine; Male; Metabolic Clearance Rate; Mice; Mice, Transgenic; Microsomes, Liver; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Phenobarbital; Pregnenolone Carbonitrile; Pyrimidines; Triazines | 2009 |
The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.
Topics: Animals; Base Sequence; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Kidney; Mice; Mice, Inbred Strains; Mice, Knockout; Microsomes, Liver; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Random Allocation; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Sequence Analysis, DNA; Transcription Factors; Transcriptional Activation | 2010 |
Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenobarbital; PPAR alpha; Pregnane X Receptor; Pregnenolone Carbonitrile; Primary Cell Culture; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Xenobiotics | 2013 |
The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers.
Topics: Animals; Biological Evolution; Cloning, Molecular; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Male; Models, Molecular; Organ Specificity; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Xenobiotics; Zebrafish; Zebrafish Proteins | 2013 |
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.
Topics: Animals; Constitutive Androstane Receptor; DNA Replication; Gene Knockout Techniques; Liver; Male; Mice, Inbred C57BL; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thyroid Gland | 2019 |
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
Topics: Animals; Constitutive Androstane Receptor; Hepatocytes; Liver; Male; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptors, Cytoplasmic and Nuclear; Thyroid Gland | 2018 |
The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.
Topics: Animals; Carcinogenesis; Cell Proliferation; Constitutive Androstane Receptor; Hepatocytes; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Sequence Analysis, RNA; Time Factors | 2021 |