Compounds > phenobarbital

phenobarbital and pregnanolone

phenobarbital has been researched along with pregnanolone in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19904 (40.00)18.7374
1990's1 (10.00)18.2507
2000's4 (40.00)29.6817
2010's0 (0.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Lombardo, F; Obach, RS; Waters, NJ1
Baird, MB; Birnbaum, LS1
Kirkness, EF; Turner, AJ1
Callachan, H; Cottrell, GA; Hather, NY; Lambert, JJ; Nooney, JM; Peters, JA1
Gielen, JE; Kremers, P; Pasleau, F1
Hodges, DR; Karavolas, HJ1
Reddy, DS; Rogawski, MA1
Lu, YQ; Yu, R1
Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T1

Reviews

1 review(s) available for phenobarbital and pregnanolone

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000

Other Studies

9 other study(ies) available for phenobarbital and pregnanolone

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Induction of hepatic mixed function oxidases in senescent rodents.
    Experimental gerontology, 1978, Volume: 13, Issue:5

    Topics: Aging; Animals; Benzopyrene Hydroxylase; Benzphetamine; Biotransformation; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ethylmorphine-N-Demethylase; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnanolone; Rats

1978
The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.
    European journal of pharmacology, 1988, Jun-10, Volume: 150, Issue:3

    Topics: Animals; Anthelmintics; Cerebral Cortex; In Vitro Techniques; Ivermectin; Muscimol; Phenobarbital; Picrotoxin; Pregnanes; Pregnanolone; Radioligand Assay; Receptors, GABA-A; Secobarbital; Sesterterpenes; Swine; Synaptic Membranes

1988
Modulation of the GABAA receptor by progesterone metabolites.
    Proceedings of the Royal Society of London. Series B, Biological sciences, 1987, Aug-21, Volume: 231, Issue:1264

    Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Phenobarbital; Pregnanediones; Pregnanes; Pregnanolone; Receptors, GABA-A

1987
Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases.
    Chemico-biological interactions, 1981, Mar-15, Volume: 34, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; Binding, Competitive; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnanolone; Progesterone; Rats; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Steroids; Substrate Specificity; Testosterone

1981
Barbiturates modulate the activity of the pituitary 3 alpha-hydroxysteroid oxidoreductases and inhibit their production of 3 alpha,5 alpha-tetrahydroprogesterone.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 45, Issue:4

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Animals; Barbital; Enzyme Induction; Female; Oxidation-Reduction; Phenobarbital; Pituitary Gland, Anterior; Pregnanolone; Rats; Rats, Sprague-Dawley; Sodium Chloride

1993
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid

2001
Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:4

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Drug Synergism; Electroshock; Flunitrazepam; GABA Modulators; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Pregnanolone; Seizures

2001
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
    Annals of neurology, 2022, Volume: 92, Issue:6

    Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; Humans; Infant, Newborn; Phenobarbital; Pregnanolone; Seizures; Sheep

2022