phenobarbital has been researched along with phenylethylmalonamide in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (77.78) | 18.7374 |
| 1990's | 6 (13.33) | 18.2507 |
| 2000's | 3 (6.67) | 29.6817 |
| 2010's | 1 (2.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Bernhardt, W; Guthoff, A; Heipertz, R | 1 |
| Göbel, W; Löscher, W | 1 |
| Friel, PN; Leal, KW; Rapport, RL; Wilensky, AJ | 1 |
| Blaschke, E; Iffland, E; Lagenstein, I; Sternowsky, HJ | 1 |
| Eickhoff, K; Heipertz, R; Pilz, H; Seidel, D | 1 |
| Crawford, RD; Davis, HL; Johnson, DD | 1 |
| Kupferberg, HJ; Sutton, G | 1 |
| Morgan, JP; Myers, GJ; Syversen, GB; Weintraub, M | 1 |
| Eickhoff, K; Heipertz, R; Pilz, H | 1 |
| McElhatton, PR; Sullivan, FM; Toseland, PA | 2 |
| Alvin, J; Bush, MT; Goh, E | 1 |
| Alvin, JD; Bush, MT | 1 |
| Goto, T; Ito, K; Kobayashi, Y; Owada, E; Sakuta, N; Sato, J; Sekizawa, Y; Yoshida, A; Yoshihara, M | 1 |
| Calzetti, S; Gatti, G; Martines, C; Perucca, E; Sasso, E | 1 |
| Berry, DJ; Groggin, MJ; Jones, JA; Streete, JM | 1 |
| Berry, DJ; Newbery, JE; Pettit, LI; Streete, JM | 1 |
| Holl, G; Honé, A; Seyfert, S | 1 |
| Findley, LJ | 1 |
| Alderdice, MT; Talbot, PA | 2 |
| Bourgeois, BF; Dodson, WE; Ferrendelli, JA | 3 |
| de Jong, W; Seldenrijk, R; van Dijk, A; van Heijst, AN | 1 |
| Frey, HH; Löscher, W; Reiche, R; Schultz, D | 1 |
| Höller, M; Penin, H | 1 |
| O'Brien, MD; Toseland, PA; Upton, AR | 1 |
| Cunningham, JG; Haidukewych, D; Jensen, HA | 1 |
| Neels, HM; Scharpé, SL; Totté, JA; Verkerk, RM; Vlietinck, AJ | 1 |
| Meijer, JW; Rambeck, B; Riedmann, M | 1 |
| Kupferberg, HJ; Newmark, ME; Porro, MG; Porter, RJ; Theodore, WH | 1 |
| Johnson, RH; Lambie, DG | 1 |
| Yeary, RA | 1 |
| Jesdinsky, D; Nau, H; Wittfoht, W | 1 |
| Häuser, I; Helge, H; Jäger, E; Koch, S; Nau, H; Rating, D | 1 |
| Frey, HH; Löscher, W | 1 |
| Cloyd, JC; Leppik, IE; Miller, KW | 1 |
| Furuno, K; Gomita, Y; Moriyama, M; Oishi, R | 1 |
| El-Masri, HA; Portier, CJ | 1 |
| Chabenat, C; Ferranti, V; Lafont, O; Ménager, S | 1 |
| Chabenat, C; Ferranti, V; Hue, H; Lafont, O; Marchais, H; Ménager, S; Orecchioni, AM | 1 |
| Cantú, MD; Carrilho, E; Lacerda, CA; Lanças, FM; Queiroz, ME; Toso, DR | 1 |
| Dünnbier, U; Hass, U; Massmann, G | 1 |
45 other study(ies) available for phenobarbital and phenylethylmalonamide
| Article | Year |
|---|---|
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Primidone metabolism in renal insufficiency and acute intoxication.
Topics: Acute Disease; Adult; Aged; Biotransformation; Female; Humans; Kidney Failure, Chronic; Phenobarbital; Phenylethylmalonamide; Primidone; Suicide, Attempted | 1979 |
Consecutive gas chromatographic determination of phenytoin, phenobarbital, primidone, phenylethylmalondiamide, carbamazepine, trimethadione, dimethadione, ethosuximide, and valproate from the same serum specimen.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Dimethadione; Ethosuximide; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Trimethadione; Valproic Acid | 1978 |
Single-dose pharmacokinetics and anticonvulsant efficacy of primidone in mice.
Topics: Animals; Biotransformation; Brain Chemistry; Dose-Response Relationship, Drug; Female; Mice; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures; Time Factors | 1979 |
Intoxication with primidone: continuous monitoring of serum primidone and its metabolites during forced diuresis.
Topics: Adolescent; Diuresis; Female; Humans; Phenobarbital; Phenylethylmalonamide; Primidone | 1977 |
[Selected clinical aspects of routine monitoring of anticonvulsant concentrations in serum (author's transl)].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Chromatography, Gas; Drug Therapy, Combination; Ethosuximide; Humans; Middle Aged; Phenobarbital; Phenylethylmalonamide; Phenytoin | 1977 |
Epileptiform seizures in domestic fowl. VIII. Anticonvulsant activity of primidone and its metabolites, phenobarbital and phenylethylmalonamide.
Topics: Animals; Anticonvulsants; Chickens; Dimethyl Sulfoxide; Female; Male; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone; Proadifen; Time Factors | 1978 |
Isoniazid as an inhibitor of primidone metabolism.
Topics: Depression, Chemical; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Isoniazid; Middle Aged; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Pyridoxine; Tuberculosis, Miliary | 1975 |
Acetazolamide-induced interference with primidone absorption. Case reports and metabolic studies.
Topics: Acetazolamide; Adolescent; Adult; Female; Humans; Intestinal Absorption; Phenobarbital; Phenylethylmalonamide; Primidone; Time Factors | 1977 |
Evaluation of a rapid gas-chromatographic method for the simultaneous quantitative determination of ethosuximide, phenyletheylmalonediamide, carbamazepine, phenobarbital, primidone and diphenylhydantoin in human serum.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Ethosuximide; Evaluation Studies as Topic; Humans; Methods; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1977 |
The metabolism of primidone in non-pregnant and 14-day pregnant mice.
Topics: Animals; Female; Mice; Phenobarbital; Phenylethylmalonamide; Pregnancy; Pregnancy, Animal; Primidone; Teratogens | 1977 |
Plasma level studies of primidone and its metabolites in the mouse at various stages of pregnancy.
Topics: Animals; Female; Gestational Age; Malonates; Metabolic Clearance Rate; Mice; Phenobarbital; Phenylethylmalonamide; Pregnancy; Pregnancy, Animal; Primidone; Teratogens | 1977 |
Study of the hepatic metabolism of primidone by improved methodology.
Topics: Animals; Bile; Carbon Radioisotopes; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Liver; Male; Perfusion; Phenobarbital; Phenylethylmalonamide; Primidone; Radiometry; Rats; Spectrophotometry, Ultraviolet; Time Factors | 1975 |
Synthesis of millimole amounts of 14C- and 2D-labelled primidone, phenylethylmalonamide and phenobarbital for high-sensitivity detection in biological materials.
Topics: Biodegradation, Environmental; Body Fluids; Carbon Radioisotopes; Chromatography, Thin Layer; Countercurrent Distribution; Deuterium; Humans; Isotope Labeling; Malonates; Mass Spectrometry; Microchemistry; Phenobarbital; Phenylethylmalonamide; Primidone | 1975 |
Single-dose kinetics of primidone in human subjects: effect of phenytoin on formation and elimination of active metabolites of primidone, phenobarbital and phenylethylmalonamide.
Topics: Adult; Biotransformation; Half-Life; Humans; Male; Middle Aged; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1992 |
The disposition of primidone in elderly patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Chromatography, High Pressure Liquid; Epilepsy; Female; Half-Life; Humans; Male; Phenobarbital; Phenylethylmalonamide; Primidone; Tremor | 1990 |
Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure.
Topics: Humans; Kidney Failure, Chronic; Male; Malonates; Middle Aged; Phenobarbital; Phenylethylmalonamide; Primidone; Renal Dialysis; Time Factors | 1990 |
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Valproic Acid | 1986 |
Primidone and essential tremor.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Phenobarbital; Phenylethylmalonamide; Primidone; Tremor | 1988 |
Essential tremor.
Topics: Diagnosis, Differential; Humans; Parkinson Disease; Phenobarbital; Phenylethylmalonamide; Primidone; Propranolol; Tremor | 1986 |
Primidone but not phenylethylmalonamide, a major metabolite, increases nerve-evoked transmitter release at the frog neuromuscular junction.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Malonates; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Phenobarbital; Phenylethylmalonamide; Primidone; Rana pipiens; Synapses | 1982 |
Interactions between primidone, carbamazepine, and nicotinamide.
Topics: Animals; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Infant; Male; Mice; Mice, Inbred Strains; Niacinamide; Phenobarbital; Phenylethylmalonamide; Primidone | 1982 |
Effects of primidone, phenobarbital and phenylethylmalonamide in the stimulated frog neuromuscular junction.
Topics: Action Potentials; Animals; Calcium; Electric Stimulation; In Vitro Techniques; Magnesium; Malonates; Motor Endplate; Neuromuscular Junction; Phenobarbital; Phenylethylmalonamide; Potassium; Primidone; Rana pipiens; Synapses | 1984 |
Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion.
Topics: Aged; Charcoal; Coma; Female; Half-Life; Hemoperfusion; Humans; Kinetics; Phenobarbital; Phenylethylmalonamide; Primidone | 1983 |
Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Electroshock; Female; Malonates; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures | 1983 |
Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice.
Topics: Animals; Brain; Brain Chemistry; Drug Synergism; Drug Therapy, Combination; Electroshock; Female; Malonates; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures | 1983 |
Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites.
Topics: Administration, Oral; Animals; Brain; Chromatography, Gas; Gerbillinae; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures | 1984 |
Studies on the intracerebral metabolism of anticonvulsant drugs--I. Perfusion of primidone through the isolated brain of the rat.
Topics: Animals; Brain; In Vitro Techniques; Male; Perfusion; Phenobarbital; Phenylethylmalonamide; Primidone; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Benign familial tremor treated with primidone.
Topics: Adolescent; Adult; Aged; Humans; Male; Middle Aged; Phenobarbital; Phenylethylmalonamide; Primidone; Propranolol; Prospective Studies; Tremor | 1981 |
Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone | 1983 |
Simultaneous high performance liquid-chromatographic determination of carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, phenobarbital, phenytoin, primidone and phenylethylmalonamide in plasma.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Ethosuximide; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1983 |
Quantitative simultaneous determination of eight common antiepileptic drugs and metabolites by liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Liquid; Ethosuximide; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Succinimides | 1981 |
Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1982 |
The effects of phenytoin on phenobarbitone and primidone metabolism.
Topics: Adult; Aged; Anticonvulsants; Drug Therapy, Combination; Humans; Middle Aged; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1981 |
Serum concentrations of primidone and its metabolites, phenylethylmalonamide and phenobarbital, in the dog.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Kinetics; Male; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone | 1980 |
Microassay for primidone and its metabolites phenylethylmalondiamide, phenobarbital and p-hydroxyphenobarbital in human serum, saliva, breast milk and tissues by gas chromatography--mass spectrometry using selected ion monitoring.
Topics: Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Kinetics; Malonates; Maternal-Fetal Exchange; Microchemistry; Milk, Human; Phenobarbital; Phenylethylmalonamide; Pregnancy; Primidone; Saliva | 1980 |
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
Topics: Adult; Aminopyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Half-Life; Humans; Hydroxylation; Infant; Infant, Newborn; Kinetics; Liver; Male; Malonates; Maternal-Fetal Exchange; Phenobarbital; Phenylethylmalonamide; Pregnancy; Pregnancy Complications; Primidone | 1980 |
[Is primidone more efficient than phenobarbital? An attempt at a pharmacological evaluation (author's transl)].
Topics: Animals; Dogs; Epilepsy; Humans; Phenobarbital; Phenylethylmalonamide; Primidone | 1980 |
Primidone kinetics: effects of concurrent drugs and duration of therapy.
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Phenylethylmalonamide; Primidone; Seizures; Time Factors | 1981 |
Simultaneous determination of primidone and its active metabolites in rat plasma by high-performance liquid chromatography using a solid-phase extraction technique.
Topics: Administration, Oral; Animals; Calibration; Chemical Phenomena; Chemistry Techniques, Analytical; Chemistry, Physical; Chromatography, High Pressure Liquid; Male; Phenobarbital; Phenylethylmalonamide; Primidone; Rats; Rats, Wistar | 1994 |
Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice.
Topics: Animals; Anticonvulsants; Humans; Mice; Models, Biological; Phenobarbital; Phenylethylmalonamide; Primidone; Rats; Species Specificity | 1998 |
Simultaneous determination of primidone and its three major metabolites in rat urine by high-performance liquid chromatography using solid-phase extraction.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Phenobarbital; Phenylethylmalonamide; Primidone; Rabbits; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 1998 |
Effects of encapsulation of primidone on its oxidative metabolism in rats.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Drug Compounding; Feces; Female; Nanotechnology; Oxidation-Reduction; Phenobarbital; Phenylethylmalonamide; Polyesters; Primidone; Rats; Rats, Sprague-Dawley | 2001 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liquid; Desipramine; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Imipramine; Lamotrigine; Nortriptyline; Phenobarbital; Phenylethylmalonamide; Polyurethanes; Primidone; Reproducibility of Results; Sensitivity and Specificity; Silanes; Time Factors; Triazines | 2006 |
Occurrence of psychoactive compounds and their metabolites in groundwater downgradient of a decommissioned sewage farm in Berlin (Germany).
Topics: Berlin; Gas Chromatography-Mass Spectrometry; Groundwater; Meprobamate; Phenobarbital; Phenylethylmalonamide; Primidone; Psychotropic Drugs; Pyridones; Sewage; Water Pollutants | 2012 |