phenobarbital has been researched along with orphenadrine in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Sen, S; Sinha, N | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Lader, MH | 1 |
| Curry, S; Lader, M; Loga, S | 1 |
| Murray, M; Reidy, GF | 1 |
| Conney, AH; Levin, W; Welch, RM | 1 |
| Funcke, AB; Timmerman, H | 1 |
| Collins, AJ; Horlington, M | 1 |
| Bast, A; Noordhoek, J; Savenije-Chapel, EM | 1 |
| Bast, A; Noordhoek, J; Savenije-Chapel, EM; van Kemenade, FA | 1 |
| Bast, A; Noordhoek, J | 1 |
| Mahnke, A; Roos, PH | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ | 1 |
| Fiala-Beer, E; Murray, M; Sutton, D | 1 |
| MERKER, HJ; REMMER, H | 1 |
| CONNEY, AH; GILMAN, AG | 1 |
| CURRAN, DA; LANCE, JW | 1 |
| BURNS, JJ; CONNEY, AH | 1 |
| DEMEL, RA | 1 |
| GOLDSTEIN, L; MURPHREE, HB; PFEIFFER, CC; SUGERMAN, AA | 1 |
| Chou, CY; Chou, YC; Tien, JH; Ueng, YF | 1 |
| Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A | 1 |
1 review(s) available for phenobarbital and orphenadrine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for phenobarbital and orphenadrine
| Article | Year |
|---|---|
Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.
Topics: Adult; Antipyrine; Chlorpromazine; Clinical Trials as Topic; Drug Interactions; Female; Half-Life; Humans; Male; Orphenadrine; Phenobarbital; Psychotic Disorders | 1975 |
23 other study(ies) available for phenobarbital and orphenadrine
| Article | Year |
|---|---|
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
[Rational utilization of the major tranquilizers].
Topics: Adult; Antipsychotic Agents; Antipyrine; Chlorpromazine; Drug Interactions; Drug Therapy, Combination; Drug Utilization; Electroencephalography; Half-Life; Humans; Liver; Male; Orphenadrine; Phenobarbital; Psychotic Disorders; Theta Rhythm; Time Factors | 1975 |
Evidence for complexation of P-450 IIC6 by an orphenadrine metabolite.
Topics: Androstenedione; Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ferricyanides; Kinetics; Microsomes, Liver; Orphenadrine; Oxidoreductases; Phenobarbital; Progesterone; Rats; Steroid Hydroxylases | 1990 |
Effect of phenobarbital and other drugs on the metabolism and uterotropic action of estradiol-17-beta and estrone.
Topics: Animals; Chlordan; Chromatography, Paper; Depression, Chemical; Estradiol; Estrone; Female; Insecticides; Liver; Microsomes; Orphenadrine; Phenobarbital; Phenylbutazone; Piperazines; Rats; Stimulation, Chemical; Time Factors; Tritium; Uterus | 1968 |
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.
Topics: Aging; Animals; Benzene Derivatives; Body Weight; Drug Tolerance; Enzyme Induction; Ethers; Ethylamines; Hexobarbital; Liver; Male; Motor Activity; Orphenadrine; Phenobarbital; Rats; Sleep; Time Factors | 1973 |
A sequential screning test based on the running component of audiogenic seizures in mice, including reference compound PD50 values.
Topics: Acetazolamide; Animals; Anticonvulsants; Atropine; Chloral Hydrate; Chlordiazepoxide; Ethosuximide; Haloperidol; Hydroxybutyrates; Hypnotics and Sedatives; Meprobamate; Methods; Mice; Motor Activity; Orphenadrine; Phenobarbital; Phenytoin; Primidone; Sound | 1969 |
Relationship between molecular structure and cytochrome P450-metabolic intermediate complex formation, studied with orphenadrine analogues.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Microsomes, Liver; Orphenadrine; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1984 |
Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Orphenadrine; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry | 1982 |
Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Kinetics; Male; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrum Analysis; Steroid 16-alpha-Hydroxylase | 1996 |
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1998 |
Upregulation of cytochromes P450 2B in rat liver by orphenadrine.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Gene Expression Regulation; Injections, Intraperitoneal; Male; Microsomes, Liver; Orphenadrine; Phenobarbital; Protein Biosynthesis; Rats; Rats, Wistar; Up-Regulation | 2003 |
DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES.
Topics: Adenosine Triphosphatases; Animals; Cytochromes; Endoplasmic Reticulum; Liver; Meprobamate; Microscopy, Electron; N-Glycosyl Hydrolases; Nikethamide; Nitrogen; Orphenadrine; Pharmacology; Phenobarbital; Phenylbutazone; Phosphoric Monoester Hydrolases; Phosphorus; Tolbutamide | 1963 |
PUROMYCIN INHIBITION OF ENZYME INDUCTION BY 3-METHYLCHOLANTHRENE AND PHENOBARBITAL.
Topics: Anti-Bacterial Agents; Antimetabolites; Azo Compounds; Enzyme Induction; Enzyme Inhibitors; Hydrolases; Liver; Methylcholanthrene; Orphenadrine; Pharmacology; Phenobarbital; Phenylbutazone; Piperazines; Puromycin; Rats; Research | 1963 |
TREATMENT OF CHRONIC TENSION HEADACHE.
Topics: Amitriptyline; Amobarbital; Anxiety; Anxiety Disorders; Biomedical Research; Chlordiazepoxide; Diazepam; Ergot Alkaloids; Ergotamine; Headache; Headache Disorders; Imipramine; Methysergide; Orphenadrine; Phenobarbital; Placebos; Psychosomatic Medicine; Selective Serotonin Reuptake Inhibitors; Serotonin; Tension-Type Headache; Tranquilizing Agents; Tranylcypromine; Trifluoperazine; Vasodilator Agents | 1964 |
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS.
Topics: Aminopyrine; Androgens; Benzopyrenes; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Ethionine; Liver; Liver Neoplasms; Methionine; Methylcholanthrene; Microsomes; Microsomes, Liver; Orphenadrine; Pharmacology; Phenobarbital; Phenylbutazone; Polycyclic Compounds; Rats; Research; Zoxazolamine | 1963 |
PENETRATION OF LIPID MONOLAYERS BY PSYCHOACTIVE DRUGS.
Topics: Brain Chemistry; Cell Membrane Permeability; Cerebrosides; Chlorpromazine; Gangliosides; Lecithins; Lipids; Meclizine; Meprobamate; Orphenadrine; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Psychotropic Drugs; Research; Reserpine; Sphingomyelins | 1965 |
TIME-SERIES, FREQUENCY ANALYSIS, AND ELECTROGENESIS OF THE EEGS OF NORMALS AND PSYCHOTICS BEFORE AND AFTER DRUGS.
Topics: Amphetamine; Antidepressive Agents; Barbiturates; Biomedical Research; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Deanol; Drug Therapy; Electroencephalography; Lysergic Acid Diethylamide; Meprobamate; Orphenadrine; Pentobarbital; Perphenazine; Pharmacology; Phenobarbital; Placebos; Schizophrenia; Statistics as Topic; Tranquilizing Agents | 1965 |
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Ketoconazole; Kinetics; Linear Models; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Morphinans; Orphenadrine; Oxidoreductases, N-Demethylating; Phenobarbital | 2005 |
Enhanced liver tumor promotion activity in rats subjected to combined administration of phenobarbital and orphenadrine.
Topics: Animals; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Drug Combinations; Drug Synergism; Enzyme Induction; Liver Neoplasms; Male; Microsomes, Liver; Orphenadrine; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2013 |