phenobarbital has been researched along with orotic acid in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (80.49) | 18.7374 |
| 1990's | 6 (14.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Clampitt, RB | 1 |
| Duceman, BW; Leonard, TB; Smith, SJ; Vesell, ES | 1 |
| Duceman, BW; Leonard, TB; Liu, DK; Smith, SJ; Vesell, ES | 1 |
| Anderson, J; Nievel, JG; Robinson, N | 1 |
| Anderson, J; Nievel, JG; Skrbic, TR | 1 |
| Gartner, LM; Vaisman, SL | 1 |
| Lynn James, GW; Parker, FL; Pickering, RW | 1 |
| Braun, W; Koslowski, H; Menzel, K | 1 |
| Columbano, A; Coni, P; Curto, M; Faa, G; Giacomini, L; Ledda-Columbano, GM; Sarma, DS | 1 |
| Manjeshwar, S; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Haines, DS; Tokmakjian, SD; Wu, M | 1 |
| Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Kintzel, HW | 1 |
| Geibel, U; Hennig, W; Kunz, W; Schneiders, B | 1 |
| Mandel, HG; Riis, M | 1 |
| Brunner, G; Grünewälder, H; Perings, E; Vido, I | 1 |
| Hollatz, R; Tempel, K | 1 |
| Hinkel, GK; Kintzel, HW; Schwarze, R | 2 |
| Gleeson, RA; Hill, RN; Smith, SJ; Vesell, ES | 1 |
| Bresnick, E; Cutroneo, KR | 1 |
| Seifert, J; Vácha, J | 1 |
| Händel, A; Hinkel, GK; Kintzel, HW; Schwarze, R | 1 |
| Fraley, EE; Paulson, DF | 1 |
| Bharucha, PE; Rao, S; Shenai, JP | 1 |
| Riede, UN; Rohr, HP; Torhorst, J | 1 |
| Cann, HM; Fukanaga, K; Goldstein, AS; Hoogenraad, NJ; Johnson, JD; Sunshine, P; Swierczewski, E | 1 |
| Hoagland, MB; Takagi, M | 1 |
| Windorfer, A | 1 |
| Chaudhuri, VP; Ghai, OP | 1 |
| Mycek, MJ | 1 |
| Remmer, H; Seifert, J | 1 |
| Cohen, AM; Ruddon, RW | 1 |
| Gumbmann, MR; Williams, SN | 1 |
| Couri, D; McCauley, R | 1 |
| Hardwick, JP; Richardson, A; Schwalm, F | 1 |
| Laconi, E; Manjeshwar, S; Rajalakshmi, S; Rao, PM; Sarma, DS; Sheikh, A | 1 |
| Laconi, E; Manjeshwar, S; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Goto, H; Makita, T; Yamashita, S | 1 |
| Goto, H; Ito, Y; Matsumoto, S; Sato, M; Senba, T; Takeuchi, K; Umehara, K; Yamada, H | 1 |
3 review(s) available for phenobarbital and orotic acid
| Article | Year |
|---|---|
Pharmacologic treatment of neonatal hyperbilirubinemia.
Topics: Adolescent; Animals; Aspartic Acid; Bilirubin; DDT; Diazepam; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Ethanol; Female; Heroin; Humans; Infant; Infant, Newborn; Intestinal Absorption; Jaundice, Neonatal; Liver; Male; Microsomes, Liver; Nikethamide; Orotic Acid; Phenobarbital; Phototherapy; Serum Albumin; Stimulation, Chemical | 1975 |
Liver tumour promotion by chemicals: models and mechanisms.
Topics: Cell Division; Choline Deficiency; Cocarcinogenesis; Humans; Liver Neoplasms; Orotic Acid; Phenobarbital; Phenotype | 1986 |
Neonatal hyperbilirubinemia--some new approaches--.
Topics: Animals; Bilirubin; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Orotic Acid; Phenobarbital; Sunlight | 1971 |
1 trial(s) available for phenobarbital and orotic acid
| Article | Year |
|---|---|
[The influence of combined therapy with orotic acid and phenobarbital on the level of serum bilirubin in premature infants].
Topics: Bilirubin; Birth Weight; Drug Combinations; Drug Synergism; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Orotic Acid; Phenobarbital | 1972 |
37 other study(ies) available for phenobarbital and orotic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Evaluation Studies as Topic; Liver Function Tests; Male; Orotic Acid; Phenobarbital; Rats | 1978 |
Differential effects of phenobarbital and 3-methylcholanthrene on rat hepatic ribosomal precursor RNA.
Topics: Animals; Cell Nucleolus; Cell Nucleus; Centrifugation, Density Gradient; Cytoplasm; DNA-Directed RNA Polymerases; Liver; Male; Methylcholanthrene; Microsomes, Liver; Orotic Acid; Phenobarbital; Rats; RNA, Ribosomal; Time Factors | 1977 |
Phenobarbital-induced increases in methylation of ribosomal precursor ribonucleic acid.
Topics: Animals; Cell Nucleolus; DNA; In Vitro Techniques; Liver; Male; Methylation; Methyltransferases; Microsomes, Liver; Orotic Acid; Phenobarbital; Rats; Ribosomes; RNA; Stimulation, Chemical | 1976 |
Changes in nucleotide metabolism of the liver and fate of [14C]orotate among various pyrimidines at the outset and during induction of drug-metabolizing enzymes and hepatomegaly.
Topics: Animals; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; DNA Replication; Enzyme Induction; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Protein Biosynthesis; Rats; Ribonucleotides; Transcription, Genetic; Uracil | 1976 |
Studies on the relationship between induction of drug-metabolizing enzymes, liver enlargement and ascorbic acid excretion in rodents.
Topics: Animals; Ascorbic Acid; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucuronates; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Proadifen; Rats; Transcription, Genetic; Uracil; Uracil Nucleotides | 1976 |
Inhibition, by drugs, of galactosamine induced hepatitis in the rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Galactosamine; Liver; Male; Orotic Acid; Phenobarbital; Prednisolone; Rats | 1975 |
[In-vitro studies on the effect of drugs on albumin-bilirubin binding].
Topics: Ampicillin; Bilirubin; Humans; In Vitro Techniques; Orotic Acid; Phenobarbital; Phenylbutazone; Protein Binding; Serum Albumin; Sulfamethoxypyridazine; Sulfathiazoles; Tolbutamide | 1975 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Nitrates; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Inhibition of DNA synthesis by phenobarbital in primary cultures of hepatocytes from normal rat liver and from hepatic nodules.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Diseases; Male; Orotic Acid; Phenobarbital; Rats; Rats, Inbred F344; Transforming Growth Factor alpha | 1992 |
Dietary orotic acid accentuates the hepatic response to phenobarbital in rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Diet; Lipid Metabolism; Male; Methyltransferases; Microsomes, Liver; Orotic Acid; Phenobarbital; Phosphatidylethanolamine N-Methyltransferase; Proteins; Rats; Rats, Inbred Strains; RNA | 1990 |
[Prevention of morbus haemolyticus neonatorum and of transitory hyperbilirubinemias of newborn infants through an enzyme inductor combination].
Topics: Bilirubin; Drug Synergism; Enzyme Induction; Erythroblastosis, Fetal; Exchange Transfusion, Whole Blood; Female; Follow-Up Studies; Glucuronosyltransferase; Humans; Infant, Newborn; Infant, Premature; Jaundice, Neonatal; Nikethamide; Orotic Acid; Phenobarbital; Pregnancy | 1973 |
[Stimulation by phenobarbital of the biosynthesis of liver ribonucleic acids].
Topics: Animals; Carbon Isotopes; Enzyme Induction; Liver; Male; Mice; Orotic Acid; Phenobarbital; Ribosomes; RNA; RNA, Messenger; Stimulation, Chemical | 1968 |
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea | 1970 |
[Studies on the effects of azathioprine, choline orotate and phenobarbital on enzymes of the endoplasmatic reticulum and mitochondria of rat liver].
Topics: Acyltransferases; Animals; Aspartate Aminotransferases; Azathioprine; Choline; Cytochrome c Group; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Glucuronates; Liver; Male; Microsomes, Liver; Mitochondria, Liver; NADP; Orotic Acid; Oxidoreductases; Phenobarbital; Rats; Succinate Dehydrogenase | 1972 |
[Induction effects in the mouse under the influence of polyanions].
Topics: Aniline Compounds; Animals; Carbon Radioisotopes; Dactinomycin; DNA; Enzyme Induction; Female; Folic Acid; In Vitro Techniques; Kidney; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Orotic Acid; Phenobarbital; Phenylalanine; Polysaccharides; Protein Biosynthesis; RNA; Sulfuric Acids | 1974 |
[Prevention of transitory hyperbilirubinemia of the premature and mature newborn infants and of the hemolytic disease of the newborn by an enzyme induction combination: phenobarbital-nikethamide].
Topics: Bilirubin; Enzyme Induction; Erythroblastosis, Fetal; Exchange Transfusion, Whole Blood; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Nikethamide; Orotic Acid; Phenobarbital; Pregnancy; Rh-Hr Blood-Group System | 1972 |
Evidence for post-transcriptional stabilization of ribosomal precursor ribonucleic acid by phenobarbital.
Topics: Adenine; Animals; Carbon Isotopes; Cell Nucleolus; Cell Nucleus; Centrifugation, Density Gradient; Chromatography; DNA; Drug Stability; Guanine; Liver; Male; Microsomes, Liver; Orotic Acid; Phenobarbital; Rats; RNA, Ribosomal; Sucrose; Transcription, Genetic; Tritium; Uracil Nucleotides | 1972 |
Induction of benzpyrene hydroxylase in fetal liver explants by flavones and phenobarbital.
Topics: Animals; Benzopyrenes; Carbon Isotopes; Dimethyl Sulfoxide; DNA; Enzyme Induction; Female; Fetus; Flavonoids; Leucine; Liver; Mixed Function Oxygenases; Organ Culture Techniques; Orotic Acid; Phenobarbital; Pregnancy; Protein Biosynthesis; Rats; RNA; Thymidine | 1973 |
Inhibition of (6- 14 C) orotic acid incorporation into the cytosine moiety of the ribonucleic acid of rat liver cytoplasmic ribosomes after phenobarbital administration.
Topics: Animals; Carbon Isotopes; Cytoplasm; Cytosine; Cytosine Nucleotides; In Vitro Techniques; Liver; Male; Orotic Acid; Phenobarbital; Rats; Ribosomes; RNA, Ribosomal; RNA, Transfer; Time Factors | 1973 |
[Effect of various drugs on serum bilirubin level in newborn infants].
Topics: Bilirubin; Diazepam; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Meprobamate; Orotic Acid; Phenobarbital; Phenylbutazone | 1973 |
Compensatory renal growth after unilateral ureteral obstruction.
Topics: Anesthesia, Intravenous; Animals; Carbon Isotopes; DNA; Hyperplasia; Hypertrophy; Kidney; Kidney Diseases; Ligation; Mice; Organ Size; Orotic Acid; Phenobarbital; Polyribosomes; Proteins; RNA; Ureter; Ureteral Obstruction | 1973 |
Hyperbilirubinemia in the newborn: management.
Topics: Agar; Humans; Infant, Newborn; Jaundice, Neonatal; Orotic Acid; Phenobarbital; Phototherapy | 1973 |
Focal proliferation of the smooth endoplasmic reticulum in the cells of the straight part of the proximal kidney tubule.
Topics: Animals; Aspirin; Cell Aggregation; Cytoplasmic Granules; Endoplasmic Reticulum; Hydrocarbons, Brominated; Hyperplasia; Kidney Tubules, Proximal; Malonates; Microsomes; Organomercury Compounds; Orotic Acid; Phenacetin; Phenobarbital; Polyamines; Polymers; Rats; Salicylamides; Starvation | 1973 |
Metabolic and genetic studies of a family with ornithine transcarbamylase deficiency.
Topics: Ammonia; Ammonium Chloride; Brain; Citrates; Dietary Proteins; Estradiol; Glucose; Heterozygote; Humans; Infant, Newborn; Intestines; Liver; Male; Metabolism, Inborn Errors; Ornithine Carbamoyltransferase; Orotic Acid; Pedigree; Peritoneal Dialysis; Phenobarbital; Proline; Seizures; Sex Factors | 1974 |
Polysome-binding capacity of membranes in the cytoplasmic extract prepared from phenobarbital treated and regenerating rat liver.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Cell Membrane; Centrifugation, Density Gradient; Chromatography, Gel; Cytoplasm; Estradiol; Ethanol; Female; Liver; Liver Regeneration; Orotic Acid; Phenobarbital; Polyribosomes; Testosterone | 1974 |
[How harmless are modern methods of treating the physiologic jaundice of neonates? (author's transl)].
Topics: Diarrhea, Infantile; Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice, Neonatal; Light; Orotic Acid; Phenobarbital; Phototherapy; Skin Diseases | 1974 |
Microsomal nucleic acid breakdown in livers of phenobarbital-treated rats.
Topics: Animals; Carbon Isotopes; Drug Tolerance; Enzyme Induction; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nucleic Acids; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains; Ribonucleases; Ribosomes; RNA; Sleep; Spectrophotometry; Time Factors | 1971 |
Suppression of synthesis of RNA present in microsomal membranes after administration of phenobarbital.
Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; Endoplasmic Reticulum; Liver; Male; Membranes; Microsomes, Liver; Organ Size; Orotic Acid; Phenobarbital; Rats; RNA; RNA, Ribosomal; RNA, Transfer; Spectrum Analysis; Ultracentrifugation; Ultraviolet Rays | 1971 |
The metabolism of ribonucleic acid in rat liver after phenobarbital administration.
Topics: Animals; Cell Nucleus; Centrifugation, Density Gradient; Cytoplasm; Male; Microsomes, Liver; Orotic Acid; Oxidoreductases; Phenobarbital; Ribosomes; RNA; Tritium | 1970 |
Effect of phenobarbital pretreatment on the ability of aflatoxin B 1 to inhibit ribonucleic acid synthesis in rat liver.
Topics: Aflatoxins; Animals; Carbon Isotopes; Cell Nucleus; DNA; Fasting; Injections, Intraperitoneal; Liver; Male; Organ Size; Orotic Acid; Phenobarbital; Rats; RNA; Statistics as Topic; Time Factors | 1970 |
Early effects of phenobarbital on cytoplasmic RNA in rat liver.
Topics: Animals; Bile Acids and Salts; Carbon Isotopes; Centrifugation, Density Gradient; Cycloheximide; Cytoplasm; Endoplasmic Reticulum; Kinetics; Leucine; Liver; Male; Membranes; Microsomes, Liver; Orotic Acid; Peptide Biosynthesis; Phenobarbital; Rats; Ribosomes; RNA; RNA, Ribosomal; Time Factors; Ultracentrifugation | 1971 |
The effect of phenobarbital on the transcriptional activity of liver.
Topics: Animals; Cytidine Monophosphate; In Vitro Techniques; Liver; Male; Orotic Acid; Phenobarbital; Poly A; Rats; RNA; RNA, Messenger; Transcription, Genetic; Uridine Triphosphate | 1983 |
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Topics: Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Mitosis; Models, Biological; Orotic Acid; Phenobarbital; Rats; Rats, Inbred F344 | 1994 |
Influence of orotic acid on multistage hepatocarcinogenesis in the rat: resistance of hepatocytes from nodules to the mitoinhibitory effects of orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Cells, Cultured; Dimethylhydrazines; DNA; DNA Replication; Liver; Liver Neoplasms, Experimental; Male; Mitosis; Orotic Acid; Phenobarbital; Rats; Rats, Inbred F344; Transforming Growth Factor alpha | 1993 |
Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital.
Topics: Analysis of Variance; Animals; Cells, Cultured; Dehydroepiandrosterone; Dietary Sucrose; Energy Intake; Fatty Liver; Liver; Male; Organ Size; Orotic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; Weight Gain | 1998 |
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Topics: Animals; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Fatty Acids; Fatty Liver; Liver; Male; Methylcholanthrene; Orotic Acid; Oxidation-Reduction; Peroxisomes; Phenobarbital; Rats, Sprague-Dawley; Sirtuin 1 | 2015 |