phenobarbital has been researched along with nadp in 472 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 406 (86.02) | 18.7374 |
| 1990's | 54 (11.44) | 18.2507 |
| 2000's | 10 (2.12) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (0.42) | 2.80 |
| Authors | Studies |
|---|---|
| Hildebraunt, AG; Roots, I | 1 |
| Badawy, AA; Evans, M | 2 |
| Hunter, AL; Neal, RA | 1 |
| Sies, H | 2 |
| Uehleke, H; Werner, T | 1 |
| Bolt, HM; Kappus, H | 1 |
| Burke, MD; Upshall, DG | 1 |
| Iwasaki, K; Kato, R; Noguchi, N; Shiraga, T | 1 |
| Lichtenberger, F; Nastainczyk, W; Ullrich, V | 1 |
| Mungikar, AM; Pawar, SS | 1 |
| Cammer, PA; Hollingworth, RM | 1 |
| Bolt, HM; Bolt, W; Buchter, A; Kappus, H | 1 |
| Abilev, SK; Fonshteĭn, LM; Shapiro, AA; Zekhnov, AM | 1 |
| Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M | 1 |
| Tappel, AL; Taylor, SL | 1 |
| Dignam, JD; Knapp, JA; Strobel, HW | 1 |
| Kato, R; Sugiura, M | 1 |
| Barak, AJ; Hahn, HK; Sorrell, MF; Tuma, DJ | 1 |
| Hori, SH; Takahashi, T | 1 |
| Aronson, I; Ivanetich, KM; Katz, ID | 1 |
| Jonsson, J | 1 |
| Furukawa, T; Karashima, D; Shigematsu, A; Takahashi, S | 1 |
| Labuc, GE; Madsen, NP | 1 |
| Münch, JD; von Wartburg, JP; Wermuth, B | 1 |
| Chance, B; Oshino, N | 1 |
| Hinson, JA; Mitchell, JR; Nelson, SD | 1 |
| Deutschmann, G; Mansuy, D; Nastainczyk, W; Ullrich, V; Wolf, CR | 1 |
| Sies, H; Weigl, K | 1 |
| Bachur, NR; Gee, MV; Gordon, SL | 1 |
| Estabrook, RW; Werringloer, J | 1 |
| Kamataki, T; Kitagawa, H | 1 |
| Klinger, W; Muller, D | 1 |
| De Raat, WK | 1 |
| Evans, RK; Kauffman, FC; Thurman, RG | 1 |
| Björkhem, I; Holmberg, I | 1 |
| Bernelli-Zazzera, A; Ferrero, ME; Orsi, R | 1 |
| Kumaki, K; Nebert, DW; Shichi, H | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 2 |
| Kennan, KA; Lin, JK; Miller, EC; Miller, JA | 1 |
| Hill, DL; Johnston, TP; Shih, TW; Struck, RF | 1 |
| Högberg, J; Kristoferson, A; Moldéus, P; Orrenius, S; Reed, DJ; Thor, H | 1 |
| Aust, SD; Dannan, GA; Moore, RW | 1 |
| Valla, D | 1 |
| Castro, JA; Diaz Gomez, MI; Godoy, HM | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 1 |
| Abakumova, OIu; Kutsenko, NG; Lerman, MI | 1 |
| Dey, AC; Senciall, IR | 1 |
| Buhler, DR; Henderson, MC; Miller, A | 1 |
| Davidson, WS; Flynn, TG | 1 |
| Iamkovoĭ, VI; Liakhovich, VV; Pospelova, LN; Tsyrlov, IB; Vaĭner, LM | 1 |
| Boyd, MR; Sasame, HA; Stiko, AW | 1 |
| Allen, JR; Hargraves, WA | 1 |
| Artigou, JY; Benhamou, JP; Descatoire, V; Pessayre, D; Wandscheer, JC | 1 |
| Freeman, RW; Harbison, RD; Oates, JA; Woosley, RL | 1 |
| Correia, MA; Dinizo, SE; Kumbara, H; Mico, BA; Ortiz de Montellano, PR; Yost, GS | 1 |
| Ballou, DP; Blake, RC; Coon, MJ; Oprian, DD | 1 |
| Coon, MJ; Oprian, DD; Vatsis, KP | 1 |
| Mohr, P; Pommerening, K; Prümke, HJ; Renneberg, R; Scheller, F; Schwarze, W; Strnad, G | 1 |
| Allen, JR; Forgue, ST; Hargraves, WA; Preston, BD; Reich, IL | 1 |
| Arcos, JC; Argus, MF; Lai, DY | 1 |
| Berman, ML | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Archakov, AI; Devichensky, VM | 1 |
| Beckett, AH; Dajani, RM; Gorrod, JW | 1 |
| Bridges, JW; Burke, MD | 1 |
| Roach, MK | 1 |
| Catignani, GL; Neal, RA | 1 |
| Grudin, R; Moldèus, P; Orrenius, S; Vadi, H | 1 |
| Marazzo, DP; Thurman, RG | 1 |
| Schulman, MP; Vatsis, KP | 1 |
| Jansson, I; Schenkman, JB | 2 |
| Caygill, CP; Diplock, AT; Giasuddin, AS; Jeffery, EH | 1 |
| Berman, MC; Ivanetich, KM; Kench, JE | 1 |
| Ernster, L; Gustafsson, JA; Hrycay, EG; Ingelman-Sundberg, M | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Ariji, F; Konno, K; Takusagawa, K; Watanabe, M | 1 |
| Cho, AK; Hodshon, BJ; Jonsson, J; Lindeke, B | 1 |
| Piette, LH; Singh, SP | 1 |
| Defer, G; Hoellinger, H; Joulin, Y; Moretti, JL | 1 |
| Sipes, IG; Weber, GL | 1 |
| Apanovitch, D; Kitareewan, S; Walz, FG | 1 |
| Devichensky, VM; Dubrov, YN; Korneva, EN; Molchanova, LD; Shcherbakov, VM | 1 |
| Konishi, Y; Mori, Y | 1 |
| Jain, MP; Ramakanth, S; Reen, RK; Singh, J; Wiebel, FJ | 1 |
| Helia, O; Pauliková, I | 1 |
| Bray, TM; Chen, GM; Janzen, EG; McCay, PB | 1 |
| Cazzaro, S; Manno, M; Rezzadore, M | 1 |
| Iannone, A; Swartz, HM; Tomasi, A; Vannini, V | 1 |
| Kim, SG; Novak, RF | 1 |
| Huupponen, R; Karvonen, I; Sormunen, R; Sotaniemi, EA | 1 |
| Bui, QD; Weisz, J; Wrighton, SA | 1 |
| Kunz, W; Scholz, W; Schütze, K; Schwarz, M | 1 |
| Blair, IA; Jajoo, HK; Klunk, LJ; Mayol, RF | 1 |
| Marks, GS; Riddick, DS | 1 |
| Cavazos, R; Diaz, RG; Farooqui, MY | 1 |
| Minotti, G | 2 |
| Amar, C; Dansette, PM; Mansuy, D; Pons, C; Smith, C | 1 |
| Park, BK; Tingle, MD | 1 |
| Tampo, Y; Yonaha, M | 1 |
| Advani, SV; Bidlack, WR; Riebow, JF; Tortoriello, P | 1 |
| Decker, RW; Magat, WJ; Malejka-Giganti, D | 1 |
| Gelboin, HV; Marks, GS; Park, SS; Riddick, DS | 1 |
| Benes, L; Stefek, M; Zelník, V | 1 |
| Isobe, M; Ozawa, N; Sone, T; Takabatake, E; Watabe, T | 1 |
| Ciaccio, PJ; Halpert, JR | 1 |
| Kramer, RA | 1 |
| Leach, MF; Lin, KH; Lindahl, R; Winters, AL | 1 |
| Kraus, M; Rehulka, J | 1 |
| Saarni, HU; Sotaniemi, EA; Stengård, JH | 1 |
| Hanzlik, RP; Traiger, GJ; Vyas, KP | 1 |
| Kärki, NT; Keinänen, K; Saarni, HU; Sotaniemi, EA; Stenbäck, F; Stengård, JH | 1 |
| Archakov, AI; Bachmanova, GI; Gordeev, SA; Kanaeva, IP; Karyakin, AV; Korneva, EN; Kuznetsova, GP; Skotselyas, ED | 1 |
| Haim, N; Nemec, J; Roman, J; Sinha, BK | 1 |
| Colby, HD; Dalal, NS; LaCagnin, LB; O'Donnell, JP | 1 |
| Cronholm, T; Ekström, G; Ingelman-Sundberg, M | 1 |
| Ayala, A; F-Lobato, M; Machado, A | 1 |
| Golly, I; Hlavica, P; Wolf, J | 1 |
| Kammerer, RC; Lampe, MA | 1 |
| Imai, Y; Sato, R; Taniguchi, H | 1 |
| Button, J; Clawson, GA; Geller, DA; Hammock, BD; Loury, DN; Moody, DE; Smuckler, EA; Taylor, LA | 1 |
| Jönsson, KH; Lindeke, B; Paulsen-Sörman, U | 1 |
| Berman, LM; Harbison, RD; James, RC; Roberts, SM; Smith, AC | 1 |
| Mulder, GJ; Nagelkerke, JF; Paul, LC; Schwarz, EP; Tijdens, RB; Winters, MF | 1 |
| Conway, JG; Evans, RK; Jerkins, AA; Kauffman, FC; Reinke, LA; Thurman, RG | 1 |
| Benediktova, SA; Devichenskiĭ, VM; Izotov, MV; Lugovaia, LV; Shcherbakov, VM | 1 |
| Elder, GH; Urquhart, AJ | 1 |
| Hodgson, E; Levi, PE; Smyser, BP | 1 |
| Head, B; James, JL; Moody, DE; Smuckler, EA; Woo, CH | 1 |
| Smith, AG; Stewart, FP | 1 |
| Gram, TE; Okine, LK | 1 |
| Strobel, HW; Takazawa, RS | 1 |
| Amouyal, G; Descatoire, V; Geneve, J; Larrey, D; Letteron, P; Pessayre, D; Tinel, M | 1 |
| Amouyal, G; Degott, C; Descatoire, V; Geneve, J; Larrey, D; Letteron, P; Pessayre, D; Tinel, M | 1 |
| Chiu, PL; Yang, SK | 1 |
| Nakamura, K; Nishigaki, T; Tanaka, M | 1 |
| Graf, H; Jung, B; Ullrich, V | 1 |
| Kuwahara, S; Mannering, GJ | 1 |
| Inoue, T; Kishi, T; Niwaguchi, T; Suzuki, S; Yasuda, T | 1 |
| Müller, F; Temmink, JH; van Bladeren, PJ; van Ommen, B | 1 |
| Hildebrandt, AG; Kahl, R; Ritter, J | 1 |
| Leo, MA; Lieber, CS | 1 |
| Madyastha, KM; Madyastha, P; Moorthy, B; Vaidyanathan, CS | 1 |
| de Ruiter, C; de Vries, J; Gobas, F; Kootstra, PR; Pinedo, HM; van Maanen, JM | 1 |
| Ando, M; Tappel, AL | 1 |
| Kato, R; Oshima, T; Takahashi, A | 1 |
| Baron, J; Isaacson, EL; LoSpalluto, J; Masters, BS; Taylor, WE | 1 |
| Davis, DC; Gillette, JR; Sasame, HA | 1 |
| Christensen, F | 1 |
| Nesković, N; Plesnicar, M; Vitorović, S | 1 |
| Adelman, RC; Cohen, BS; Freeman, C | 1 |
| Lehrmann, C; Rummel, W; Ullrich, V | 1 |
| Berggren, M; Ericsson, JL; Rane, A; Yaffe, S | 1 |
| Rösen, P; Stier, A | 1 |
| Van Dyke, RA; Wood, CL | 1 |
| Tabarelli, S; Uehleke, H | 1 |
| Hrycay, EG; O'Brien, PJ | 2 |
| Bickel, MH; Willi, P | 1 |
| Ito, A; Minakami, S; Takeshige, K | 1 |
| Negishi, M; Omura, T | 1 |
| Spratt, JL | 1 |
| Jondorf, WR; MacIntyre, DE; Powis, G | 1 |
| Moffitt, AE; Murphy, SD | 1 |
| Björkhem, I; Gustafsson, J | 1 |
| Bolt, HM; Kappus, H; Remmer, H | 2 |
| Mazel, P; Shargel, L | 2 |
| Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ | 1 |
| Leibman, KC | 3 |
| Huskisson, NS; Peters, RA; Shorthouse, M; Thorne, CJ; Ward, PF | 1 |
| Neal, RA; Norman, BJ; Roth, JA | 1 |
| Fujita, T; Mannering, GJ | 1 |
| Pietruszko, R | 1 |
| Hildebrandt, AG; Roots, I; Speck, M | 1 |
| Richards, TC | 1 |
| Deitrich, RA; Erwin, VG | 1 |
| Gonasun, LM; Kocsis, JJ; Snyder, R; Witmer, C | 1 |
| Gibbons, GF; Mitropoulos, KA | 1 |
| Mezey, E; Robles, EA | 1 |
| Hansen, W; Scholz, R; Thurman, RG | 1 |
| Greene, FE; Stevens, JT | 1 |
| Patel, JM; Pawar, SS | 2 |
| De Matteis, F; Seawright, AA | 1 |
| Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; McCay, PB; Poyer, JL | 1 |
| Levin, W; Lu, AY; Ryan, D; West, S | 1 |
| Gaylor, JL; Miyake, Y; Morris, HP | 1 |
| Caygill, CP; Diplock, AT; Jeffery, EH | 1 |
| Bartosek, I; Garattini, S; Guaitani, A; Simonazzi, I | 1 |
| Kampffmeyer, HG | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Boose, R; May, HE; Reed, DJ | 1 |
| Kuwahara, S; Mannering, GJ; Omura, T | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| Dalvi, RR; Neal, RA; Poore, RE | 1 |
| Neal, RA; Norman, BJ; Poore, RE | 1 |
| Kahl, GF; Kahl, R; Niedermeier, F; Tüttenberg, KH | 1 |
| Bock, KW | 1 |
| Grundin, R; Moldéus, P; Orrenius, S; Vadi, H | 1 |
| Higgins, JA | 1 |
| Lichtenberger, F; Staudt, H; Ullrich, V | 1 |
| Björkhem, I; Danielsson, H | 2 |
| Scharf, R; Ullrich, V | 1 |
| Gupta, RP; Raj, HG; Santhanam, K; Venkitasubramanian, TA | 1 |
| Estabrook, RW; Hrycay, EG | 1 |
| Gayathri, AK; Padmanaban, G | 1 |
| Coon, MJ; Vermilion, JL | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Björkhem, I; Danielsson, H; Wikvall, K | 2 |
| Balny, C; Debey, P; Douzou, P | 1 |
| Albrecht, R; Manchon, P; Pélissier, MA; Rospars, JP | 1 |
| Alexandrov, K; Frayssinet, C | 1 |
| Betz, H; Gratzl, M; Remmer, H | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Aust, SD; Pederson, TC | 1 |
| Rous, S | 1 |
| Strickhart, FS; Yang, CS | 1 |
| Ullrich, V; Weber, P | 1 |
| Behrens, BC; Bryan, GT; Ichikawa, M; Wang, CY | 1 |
| Baron, J; Estabrook, RW; Lambeth, D; Mason, JI; Waterman, M | 1 |
| Jerina, DM; Levin, W; Lu, AY; Selander, H | 1 |
| Cashaw, JL; Davis, VE; Hamlin, TA; McLaughlin, BR | 1 |
| Duppel, W; Mansuy, D; Ruf, HH; Ullrich, V | 1 |
| Martin, YC | 1 |
| Conney, AH; Kuntzman, R; Welch, R | 1 |
| Crane, FL; Prezbindowski, KS; Sun, FF | 1 |
| Ericsson, JL; Ernster, L; Orrenius, S | 1 |
| Kerza-Kwiatecki, A; Mazel, P; Simanis, J | 1 |
| Imai, Y; Sato, R | 1 |
| Jick, H; Shuster, L | 1 |
| Neal, RA | 1 |
| Tepperman, HM; Tepperman, J | 1 |
| Ernster, L; Orrenius, S | 1 |
| Hagihara, B; Ichikawa, Y; Yamano, T | 1 |
| Gillette, JR; Hernandez, PH; Mazel, P | 1 |
| Kato, R | 1 |
| Burstein, S | 1 |
| Arcasoy, M; Benditt, EP; Smuckler, EA | 1 |
| Fouts, JR; Gram, TE; Wilson, JT | 1 |
| Mitropoulos, KA; Myant, NB; Suzuki, M | 1 |
| Estabrook, RW | 1 |
| Das, ML; Ernster, L; Orrenius, S | 1 |
| Leibman, KC; Ortiz, E | 1 |
| Lange, G | 2 |
| Nestel, K; Uehleke, H | 1 |
| Bergstrand, A; Dallner, G; Nilsson, R | 1 |
| Gaylor, JL; Mason, HS; Miyake, Y | 1 |
| Kato, R; Onoda, K; Takahashi, A; Takanaka, A | 1 |
| Kuss, E | 1 |
| Jones, TM; Kupfer, D; Partridge, R | 1 |
| Ullrich, V | 1 |
| Abiko, Y; Shimizu, M; Tomikawa, M | 1 |
| Strittmatter, CF; Umberger, FT | 1 |
| Agosin, M; Gil, L; Letelier, ME; Scaramelli, N | 1 |
| Degkwitz, E; Staudinger, H; Ullrich, V | 1 |
| Coon, MJ; Junk, KW; Lu, AY | 1 |
| Ichihara, K; Kusunose, E; Kusunose, M | 1 |
| Fouts, JR; Peters, MA | 3 |
| Campbell, PN; Lawford, GR; Ragnotti, G | 1 |
| Schnitger, F; Uehleke, H | 1 |
| Baron, J; Tephly, TR | 2 |
| Coon, MJ; Lu, AY; Strobel, HW | 1 |
| Kato, R; Oshima, T; Takanaka, A | 1 |
| Gillette, JR | 2 |
| Lisboa, BP; Orrenius, S; von Bahr, C | 1 |
| Castagna, M; Chauveau, J | 1 |
| Scholz, R; Thurman, RG | 2 |
| Hardonk, MJ; Koudstaal, J | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 1 |
| Donahue, JD; Johnson, RK; Jondorf, WR; Miller, HH | 1 |
| Scholz, R; Thurman, G | 1 |
| Erwin, VG; Tabakoff, B | 1 |
| Estabrook, RW; Hildebrandt, A; Ullrich, V | 1 |
| Frommer, U; Staudinger, H; Ullrich, V | 1 |
| Cohen, JL; Jao, JY | 1 |
| Brauser, B; Sies, H | 1 |
| Carlson, GP; DuBois, KP | 1 |
| Kupfer, D; Partridge, R | 1 |
| Cronholm, T; Johansson, G | 1 |
| Lange, G; Thun, KJ | 1 |
| Brodie, BB; Cho, AK; Gillette, JR; Krishna, G; Reid, WD; Sipes, G | 1 |
| Gaylor, JL; Moir, NJ; Yanni, JB | 1 |
| Chatfield, DH; Morton, DM | 1 |
| Hariratnajothi, N; McLean, AE; Saggers, VH | 1 |
| Kutt, H; Verebely, K | 1 |
| Adelman, RC | 1 |
| Kuriyama, Y; Omura, T | 1 |
| Diehl, H; Ullrich, V | 1 |
| Kahl, GF | 1 |
| Deitrich, RA | 1 |
| Estabrook, RW; Franklin, MR | 1 |
| Estabrook, RW; Hildebrandt, A | 1 |
| Jakobsson, S; Orrenius, S; Thor, H | 1 |
| Dallner, G; Glaumann, H | 1 |
| Johansson, G | 1 |
| Davis, DC; Gillette, JR; Gram, TE; Reagan, RL; Schroeder, DH | 1 |
| Brodie, BB; Cho, AK; Krishna, G; Reid, WD | 1 |
| Carter, EA; Isselbacher, KJ | 1 |
| Feller, DR; Gillette, JR; Morita, M | 1 |
| Alvares, AP; Kappas, A; Mitani, F; Sassa, S | 1 |
| Lombrozo, L; Mitoma, C | 1 |
| Davis, DC; Gram, TE; Guarino, AM; Reagan, RL; Schroeder, DH | 1 |
| Masters, BS; Ziegler, DM | 1 |
| Bronaugh, RL; Erwin, VG; Tabakoff, B | 1 |
| Garner, JV; Garner, RC; Hanson, RS; Miller, EC; Miller, JA | 1 |
| Glazer, RI; Sartorelli, AC | 1 |
| Baron, J; Estabrook, RW; Hildebrandt, A | 1 |
| Jansson, I; Orrenius, S; Ramstad, E; Wilson, BJ | 1 |
| Diaugustine, RP; Eling, TE; Fouts, JR | 1 |
| Glaumann, H | 1 |
| Dallman, PR; Goodman, J; Thaler, MM | 1 |
| Heni, N | 1 |
| Mattocks, AR; White, IN | 1 |
| Gnosspelius, Y; Orrenius, S; Thor, H | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Lu, AY; West, S | 1 |
| Solymoss, B; Toth, S; Varga, S; Werringloer, J; Zsigmond, G | 1 |
| Altman, FP | 1 |
| Butcher, RG | 1 |
| Brown, BR | 1 |
| Glazer, RI; Sartorelli, AC; Schenkman, JB | 1 |
| Flynn, EJ; Lynch, M; Zannoni, VG | 1 |
| Aust, SD; Pederson, TC; Roerig, DL | 1 |
| DeCarli, LM; Lieber, CS | 1 |
| Chopra, P; Nayak, NC; Ramalingaswami, V; Roy, S | 1 |
| Van Dyke, RA; Wineman, CG | 1 |
| Balny, C; Debey, P | 1 |
| Kupfer, D; Levin, E | 1 |
| Roy, AB | 1 |
| McIntosh, DA; Topham, JC | 1 |
| Ernster, L; Jansson, I; Orrenius, S; Schenkman, JB | 1 |
| Thaler, MM | 1 |
| Jacobson, MM; Kuntzman, R; Poland, A; Tsai, I | 1 |
| Williams, RT | 1 |
| Carlson, GP; Fausto, N; Fuller, GC; Suarez, KA | 1 |
| Garner, RC; Miller, EC; Miller, JA | 1 |
| Brunner, G; Grünewälder, H; Perings, E; Vido, I | 1 |
| Lu, AY; West, SB | 1 |
| Stohs, SJ; Talcott, RE | 1 |
| Cooper, DY; Czygan, P; Greim, H; Hutterer, F; Popper, H; Rosenthal, O; Schaffner, F; Trülzsch, D | 1 |
| Becking, GC | 1 |
| Alexandrova, TA; Archakov, AI; Bokhon'ko, AI; Karuzina, II; Panchenco, LF | 1 |
| Frommer, U; Orrenius, S; Staudinger, H; Ullrich, V | 1 |
| Belpaire, FM; Lee, NH | 1 |
| Nebert, DW; Poland, AP | 1 |
| Kamm, JJ; Szuna, A | 1 |
| Allen, LM; Creaven, PJ | 1 |
| Cederbaum, AI; Krikun, G | 1 |
| Bernacchi, AS; Castro, JA; de Castro, CR; Fernández, G; Villarruel, MC | 1 |
| Bradshaw, JJ; Ivanetich, KM; Ziman, MR | 2 |
| Hakim, J; Järvisalo, J; Torres, M | 1 |
| Capdevila, J; Chacos, N; Estabrook, RW; Prough, RA; Renneberg, R | 1 |
| Cederbaum, AI; Winston, GW | 1 |
| Archakov, AI; Zhukov, AA | 2 |
| Narimatsu, S; Watanabe, K; Yamamoto, I; Yoshimura, H | 1 |
| Bolt, HM; Filser, JG; Schmiedel, G | 1 |
| Bäckström, D; Ehrenberg, A; Ingelman-Sundberg, M | 1 |
| Belinsky, SA; Kauffman, FC; Thurman, RG | 1 |
| Gadeholt, G | 1 |
| Evces, S; Lindahl, R | 1 |
| Kagan, VE; Savov, VM; Serbinova, EA | 1 |
| Acebo, AL; Alworth, WL; Gan, LS | 1 |
| Belghiti, J; Danan, G; Fouin-Fortunet, H; Lettéron, P; Pessayre, D; Tinel, M | 1 |
| Mukhtar, H; Seth, PK; Srivastava, SP | 1 |
| Jönsson, KH; Lindeke, BG; Paulsen-Sörman, UB | 1 |
| Baillie, TA; Dahlin, DC; Nelson, SD; Streeter, AJ | 1 |
| Capdevila, J; Estabrook, RW; Prough, RA | 1 |
| Hales, BF; Jain, R | 1 |
| Gourlay, GK; Penglis, S; Stock, BH | 1 |
| Andersson, KK; Bonfils, C; Dalet, C; Maurel, P | 1 |
| Lowery, C; Orton, TC | 1 |
| Paine, AJ | 1 |
| Ebel, RE | 1 |
| Fujii, K; Miki, N; Miyake, Y; Morio, M; Sugiyama, T; Yamano, T | 1 |
| Bast, A; Brenninkmeijer, JW; Noordhoek, J; Savenije-Chapel, EM | 1 |
| Johnson, EF; Liem, HH; Muller-Eberhard, U | 1 |
| Aasen, AJ; Hansen, CE; Pedersen, JI; Støren, O; Størmer, FC | 1 |
| Mercurio, SD; Nemeth, AM | 1 |
| Golly, I; Hlavica, P; Mietaschk, J | 1 |
| Aune, T; Dybing, E; Nelson, SD | 1 |
| Baumann, M | 1 |
| Citti, L; Gervasi, P; Testai, E; Turchi, G | 1 |
| Erjomin, AN; Metelitza, DI; Tishchenko, IV; Usanov, SA | 1 |
| Chadha, A; Madyastha, KM | 1 |
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| Jean, PA; McNett, DA; Meeks, RG; Plotzke, KP | 1 |
12 review(s) available for phenobarbital and nadp
| Article | Year |
|---|---|
The oxygen sensing characteristics of microsomal enzymes.
Topics: Animals; Carbon Monoxide; Coenzyme A; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Ethylmorphine-N-Demethylase; Flavoproteins; Hydrogen Peroxide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen; Oxygen Consumption; Peroxidases; Phenobarbital; Superoxides | 1977 |
Mixed function oxidation and intermediary metabolism: metabolic interdependencies in the liver.
Topics: Aminopyrine; Animals; Biotransformation; Dihydroxyacetone; Gluconeogenesis; Glucose; Lactates; Lipids; Liver; NADP; Nitroanisole O-Demethylase; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Tritium; Water | 1975 |
Cytochrome P-450 and its role in drug metabolism.
Topics: Adrenalectomy; Animals; Carbon Tetrachloride; Cytochromes; Dealkylation; Deamination; Enzyme Induction; Female; Glucocorticoids; Hydroxylation; Male; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Polycyclic Compounds; Pseudomonas; Rats; Sex Factors; Spectrum Analysis; Spironolactone; Ultraviolet Rays | 1972 |
Enzyme adaptation as a biochemical probe of development and aging.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Animals, Newborn; Blood Glucose; Diet; Dihydrolipoamide Dehydrogenase; Female; Glucokinase; Glucose; Liver; Male; NADP; Oxidoreductases; Phenobarbital; Pituitary Hormones; Pregnancy; Rats; Time Factors; Tritium; Tyrosine Transaminase | 1972 |
Hydroxylations in biosynthesis and metabolism of bile acids.
Topics: Acetates; Animals; Bile Acids and Salts; Biliary Tract Diseases; Carbon Monoxide; Carbon Radioisotopes; Chenodeoxycholic Acid; Cholesterol; Cholic Acids; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Enzyme Activation; Hydroxylation; Hyperthyroidism; Liver; Magnesium; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Phospholipids; Rats; Taurocholic Acid; Thyroid Hormones; Tritium | 1974 |
Factors influencing steroid hydroxylases in liver microsomes.
Topics: Age Factors; Animals; Carbon Isotopes; Chlordan; DDT; Dogs; Estradiol; Guinea Pigs; Hexobarbital; In Vitro Techniques; Insecticides; Liver; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen Consumption; Phenobarbital; Phenylbutazone; Phosphates; Polycyclic Compounds; Proadifen; Progesterone; Rabbits; Rats; Sex Factors; Steroids; Testosterone | 1966 |
Current trends in hepatic response tests.
Topics: Aminopyrine; Animals; Ascorbic Acid; Circadian Rhythm; Cold Temperature; Cytochromes; DDT; Dietary Carbohydrates; Dietary Proteins; Dogs; Enzyme Induction; Guinea Pigs; Hepatomegaly; Hexobarbital; Humans; Hydrocarbons; Liver; Mice; Microsomes, Liver; NADP; Organ Size; Phenobarbital; Rabbits; Rats | 1969 |
Join the microsomal bandwagon.
Topics: Age Factors; Animals; Anthracenes; Carbon Disulfide; Dichlorodiphenyldichloroethane; Endoplasmic Reticulum; Enzyme Induction; Female; Hepatomegaly; Male; Microsomes, Liver; NADP; Phenobarbital; Phenytoin; Phospholipids; Protein Biosynthesis; Rats; Sex Factors; Steroids; Testosterone; Transferases | 1970 |
Age-dependent effects in enzyme induction--a biochemical expression of aging.
Topics: Adipose Tissue; Aging; Animals; Cell Division; Diet; Electron Transport Complex IV; Enzyme Induction; Enzymes; Fasting; Genes; Glucokinase; Glucosephosphate Dehydrogenase; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Microsomes, Liver; NADP; Parabiosis; Phenobarbital; Phosphofructokinase-1; Pyruvate Kinase; Rats; Tryptophan Oxygenase; Tyrosine Transaminase | 1971 |
Hepatic metabolism of drugs.
Topics: Animals; Benzene; Biotransformation; Codeine; Cytochromes; Endoplasmic Reticulum; Humans; Kidney; Liver; Mitochondria, Liver; NADP; Pharmaceutical Preparations; Phenacetin; Phenobarbital; Phenols; Serotonin; Thalidomide; Thiopental | 1972 |
Hepatic cytochrome P-450.
Topics: Adrenodoxin; Age Factors; Animals; Binding Sites; Biotransformation; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Diet; Drug Synergism; Electron Transport; Enzyme Induction; Half-Life; Hydroxylation; Iron; Microsomes, Liver; Models, Chemical; Molecular Weight; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Polycyclic Compounds; Sex Factors; Species Specificity; Substrate Specificity | 1981 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; 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Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea | 2022 |
1 trial(s) available for phenobarbital and nadp
460 other study(ies) available for phenobarbital and nadp
| Article | Year |
|---|---|
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes.
Topics: Animals; Azides; Ethanol; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone; Rats; Scopoletin | 1975 |
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.
Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Humans; Hydrocortisone; Liver; Male; Morphine; NADP; Nicotinyl Alcohol; Phenobarbital; Premedication; Pyridines; Rats; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1975 |
Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Thiones; Time Factors | 1975 |
Proceedings: Monooxygenase activity and nicotinamide nucleotide systems in perfused rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Liver; NADP; Nicotinamide Mononucleotide; Oxidation-Reduction; Phenobarbital; Rats | 1975 |
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1975 |
Irreversible protein binding of norethisterone (norethindrone) epoxide.
Topics: Animals; Cattle; Cytosol; Epoxy Compounds; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Norethindrone; Phenobarbital; Protein Binding; Rats; Serum Albumin, Bovine; Xanthine Oxidase | 1976 |
Species and phenobarbitone-induced differences in the kinetic constants of liver microsomal harmine O-demethylation.
Topics: Animals; Cats; Cattle; Guinea Pigs; Harmine; Kinetics; Mice; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rabbits; Rats; Sleep; Species Specificity | 1976 |
Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Female; Kinetics; Liver; Male; Microsomes, Liver; NADP; Oxides; Phenobarbital; Rats; Sex Factors | 1976 |
Cytochrome P450 as an oxene transferase.
Topics: Anaerobiosis; Animals; Benzene Derivatives; Benzopyrenes; Coumarins; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethyl Ethers; Hot Temperature; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature; Transferases | 1976 |
Dioxane-induced changes in mouse liver microsomal mixed function oxidase system.
Topics: Animals; Ascorbic Acid; Cytochrome P-450 Enzyme System; Cytochromes; Dioxanes; Dioxins; Female; Heme; Lipid Metabolism; Liver; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADP; Organ Size; Oxidoreductases; Peroxides; Phenobarbital | 1976 |
Unusual substrate specificity in the oxidative dearylation of paraoxon analogs by mouse hepatic microsomal enzymes.
Topics: Animals; Chemical Phenomena; Chemistry; Hydrolysis; Kinetics; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Paraoxon; Phenobarbital; Rana pipiens | 1976 |
Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro.
Topics: Alkylation; Animals; Biotransformation; Epoxide Hydrolases; Glutathione; In Vitro Techniques; Male; Membranes; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Proteins; Rats; Time Factors; Vinyl Chloride; Vinyl Compounds | 1976 |
[Effect of mutagenic metabolic activation of N-nitrosomorpholine on microorganisms].
Topics: Animals; Liver; Morpholines; Mutagens; NADP; Nitroso Compounds; Phenobarbital; Rats; Salmonella typhimurium | 1976 |
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes | 1976 |
Effect of dietary antioxidants and phenobarbital pretreatment on microsomal lipid peroxidation and activation by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diet; Fatty Acids; Kinetics; Lipid Metabolism; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Peroxidases; Phenobarbital; Rats; Selenium; Vitamin E | 1976 |
NADPH-cytochrome P-450 reductase. Circular dichroism and physical studies.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Hydrocortisone; Male; Microsomes, Liver; Molecular Weight; NADP; Phenobarbital; Protein Conformation; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet | 1977 |
Reduction of tertiary amine N-oxides by rat liver mitochondria.
Topics: Adenosine Triphosphate; Amines; Aniline Compounds; Animals; Antimycin A; Benzothiazoles; Carbon Monoxide; Citric Acid Cycle; Cyanides; Dicarboxylic Acids; Digitonin; Imipramine; In Vitro Techniques; Male; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Oxygen; Phenobarbital; Piperazines; Rats; Rotenone; Thiazoles; Tricarboxylic Acids | 1977 |
Phenobarbital-induced enzymatic and non-enzymatic lipid peroxidation in rat liver microsomes.
Topics: Adenosine Diphosphate; Animals; Ascorbic Acid; Ferrous Compounds; Lipid Metabolism; Male; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Rats; Stimulation, Chemical | 1977 |
Latency of microsomal hexose-6-phosphate dehydrogenase activity.
Topics: Alcohol Oxidoreductases; Alkalies; Animals; Carboxylic Ester Hydrolases; Cell-Free System; Detergents; Dietary Carbohydrates; Enzyme Activation; Glucosephosphate Dehydrogenase; Hexosephosphates; Hydrogen-Ion Concentration; Kinetics; Lipids; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Solubility; Sonication | 1977 |
The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Vinyl Chloride; Vinyl Compounds | 1977 |
On the aromatic hydroxylation of amphetamine in rat liver microsomes and perfused liver preparations: effects of long-term administration.
Topics: Administration, Oral; Amphetamines; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Desipramine; Fenfluramine; Hydroxylation; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Perfusion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Formaldehyde formation as a metabolite of methoxyflurane.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Formaldehyde; Haplorhini; Male; Methoxyflurane; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Rabbits; Rats | 1977 |
Inhibition by 3'-methyl-4-dimethylamino-azobenzene of in vitro cell-free protein synthesis: possible involvement of an electrophilic metabolite.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cell-Free System; Cysteine; Depression, Chemical; Glutathione; In Vitro Techniques; Leucine; Liver; Male; Methyldimethylaminoazobenzene; NADP; Oxidoreductases; p-Dimethylaminoazobenzene; Phenobarbital; Polyethylene Glycols; Protein Biosynthesis; Rats | 1977 |
Purification and properties of NADPH-dependent aldehyde reductase from human liver.
Topics: Alcohol Oxidoreductases; Aldehydes; Amino Acids; Circular Dichroism; Female; Humans; Hydantoins; Hydrogen-Ion Concentration; Isoelectric Point; Kinetics; Liver; Male; Molecular Weight; NADP; Phenobarbital; Pyrazoles; Spectrophotometry | 1977 |
Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase.
Topics: Aminopyrine; Animals; Benzylamines; Catalase; Cell Separation; Glutathione; Glutathione Peroxidase; Glycolates; Liver; Male; Mitochondria, Liver; NADP; Nucleotides; Oxidation-Reduction; Perfusion; Peroxides; Phenobarbital; Rats; Triazoles; Uric Acid | 1977 |
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital | 1977 |
The reduction of polyhalogenated methanes by liver microsomal cytochrome P450.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrocarbons, Halogenated; In Vitro Techniques; Light; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Infrared; Time Factors | 1977 |
Drug oxidations dependent on cytochrome P-450 in isolated hepatocytes. The role of the tricarboxylates and the aminotransferases in NADPH supply.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aminooxyacetic Acid; Aminopyrine N-Demethylase; Animals; Cycloserine; Cytochrome P-450 Enzyme System; Cytosol; In Vitro Techniques; Liver; Male; Mitochondria, Liver; Mixed Function Oxygenases; Models, Biological; NADP; Phenobarbital; Rats; Transaminases; Tricarboxylic Acids | 1977 |
Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.
Topics: Animals; Anthracenes; Antibiotics, Antineoplastic; Biotransformation; Daunorubicin; Doxorubicin; Electron Transport; Enzyme Induction; Free Radicals; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Microsomes, Liver; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; NADP; Oxygen Consumption; Phenobarbital; Rats; Stimulation, Chemical | 1977 |
The involvement of cytochrome P-450 in the NADH-dependent O-demethylation of p-nitroanisole in phenobarbital-treated rabbit liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Male; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Rabbits | 1977 |
Developmental aspects of xenobiotic transformation.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethylmorphine; Female; Glucosephosphates; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes, Liver; NAD; NADP; Niacinamide; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pregnancy; Rats; Semicarbazides | 1976 |
The induction of sister chromatid exchanges by cyclophosphamide in the presence of differently induced microsomal fractions of rat liver.
Topics: Animals; Aroclors; Benzopyrene Hydroxylase; Cells, Cultured; Chromatids; Cyclophosphamide; Enzyme Induction; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats | 1977 |
Alterations in nicotinamide and adenine nucleotide systems during mixed-function oxidation of p-nitroanisole in perfused livers from normal and phenobarbital-treated rats.
Topics: Adenine Nucleotides; Animals; Anisoles; Dinitrophenols; Female; Glutamates; Hydroxy Acids; In Vitro Techniques; Liver; Mixed Function Oxygenases; NAD; NADP; Oxidoreductases; Phenobarbital; Pyruvates; Rats | 1977 |
Assay and properties of a mitochondrial 25-hydroxylase active on vitamine D3.
Topics: Animals; Cholecalciferol; Gas Chromatography-Mass Spectrometry; Hydroxycholecalciferols; Male; Mitochondria, Liver; NADP; Phenobarbital; Rats; Steroid Hydroxylases | 1978 |
Effects of ischemia on drug-metabolizing microsomal enzymes in rat liver.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Endoplasmic Reticulum; Inactivation, Metabolic; Ischemia; Liver Circulation; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Premedication; Rats; Succinate Dehydrogenase; Time Factors | 1978 |
Circular dichroism studies on the binding of type I substrates and reverse type I compounds to rabbit liver microsomal cytochrome P-450.
Topics: Alcohols; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Circular Dichroism; Cyclohexanes; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rabbits | 1978 |
Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Catalysis; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethyl Ethers; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats | 1978 |
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.
Topics: Aflatoxins; Animals; Chemical Phenomena; Chemistry; Cricetinae; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats | 1978 |
Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane.
Topics: Animals; DNA; Ethylene Dibromide; Glutathione Transferase; Hydrocarbons, Brominated; In Vitro Techniques; Kidney; Kinetics; Liver; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Proteins; Rats; RNA | 1978 |
Metabolic activation and hepatotoxicity. Metabolism of bromobenzene in isolated hypatocytes.
Topics: Animals; Biological Transport; Biotransformation; Bromobenzenes; In Vitro Techniques; Liver; Male; Microsomes, Liver; NAD; NADP; Phenobarbital; Protein Binding; Rats | 1978 |
Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
Topics: Animals; Biotransformation; Biphenyl Compounds; DNA; Female; Lactation; Male; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Phenobarbital; Polybrominated Biphenyls; Pregnancy; Protein Binding; Rats | 1978 |
[Hepatic metabolism of foreign substances. Enzymatic hydroxylation system of hepatic microsomes and of cytochrome P-450].
Topics: Anticoagulants; Benzopyrenes; Biotransformation; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethanol; Humans; Hydroxylation; Iproniazid; Isoniazid; Liver; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital | 1978 |
Mechanism of dimethylnitrosamine metabolism and activation in rats.
Topics: Animals; Biotransformation; Carbon Dioxide; Cobalt; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrosamines; Nucleic Acids; Phenobarbital; Proadifen; Protein Binding; Rats; Subcellular Fractions | 1978 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
[Metabolic activation of N-methyl-N-nitrosourea in normal and tumor cells].
Topics: Alkylating Agents; Animals; Azides; Benzopyrenes; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylnitrosourea; Mice; Microsomes, Liver; NADP; Nitrosourea Compounds; Phenobarbital | 1978 |
Acidic steroid metabolites: biosynthesis of steroid carboxylic acids by rabbit liver microsomes and the involvement of a cytochrome P450-independent mixed function oxidase system.
Topics: Androstenes; Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Female; Hydrogen-Ion Concentration; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NAD; NADP; Nitrogen; Oxidoreductases; Phenobarbital; Progesterone; Rabbits | 1978 |
Covalent binding of carbaryl (1-naphthyl-N-methyl-carbamate) to rat liver microsomes in vitro.
Topics: Animals; Carbaryl; Electrophoresis, Disc; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pronase; Protein Binding; Rats | 1979 |
Kinetics and mechanism of action of aldehyde reductase from pig kidney.
Topics: Aldehyde Oxidoreductases; Animals; Glyceraldehyde; Kidney; Kinetics; Models, Chemical; NADP; Phenobarbital; Swine | 1979 |
[Cytochrome P-450 catalyzed oxidation of 1-piperidinoanthraquinone].
Topics: Animals; Anthraquinones; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme System; Deoxycholic Acid; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Piperidines; Rats; Spectrum Analysis | 1979 |
Metabolic activation of nitrofurantoin--possible implications for carcinogenesis.
Topics: Aerobiosis; Anaerobiosis; Animals; Biotransformation; Carcinogens; Flavin-Adenine Dinucleotide; Lung; Male; Microsomes; Microsomes, Liver; NADP; Nitrofurantoin; Phenobarbital; Rats; Rats, Inbred Strains; Tissue Distribution | 1979 |
The in vitro binding of 2,2', 5,5'-tetrachlorobiphenyl metabolites to rat liver microsomal proteins.
Topics: Animals; Dialysis; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Protein Binding; Rats; Ultracentrifugation | 1979 |
Formation and inactivation of a chemically reactive metabolite of vinyl chloride.
Topics: Animals; Cysteine; Cytochrome P-450 Enzyme System; DDT; Epoxide Hydrolases; Epoxy Compounds; Glutathione; Hydrocarbons, Chlorinated; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Protein Binding; Rats; Vinyl Chloride; Vinyl Compounds | 1979 |
Evidence for the biotransformation of procainamide to a reactive metabolite.
Topics: Acetylation; Animals; Biotransformation; Hydralazine; Male; Mice; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Procainamide; Salmonella typhimurium | 1979 |
Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: mass spectrometric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Epoxy Compounds; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Liver; Mass Spectrometry; Microsomes, Liver; NADP; Phenobarbital; Porphyrins; Rats | 1979 |
Mechanistic studies with purified components of the liver microsomal hydroxylation system: spectral intermediates in reaction of cytochrome P-450 with peroxy compounds.
Topics: Anaerobiosis; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Electron Transport; Hydroxylation; Kinetics; Microsomes, Liver; NADP; Oxidation-Reduction; Peroxides; Phenobarbital; Phosphatidylcholines; Spectrophotometry | 1979 |
Kinetics of reduction of purified liver microsomal cytochrome P-450 in the reconstituted enzyme system studied by stopped flow spectrophotometry.
Topics: Animals; Benzoflavones; Benzphetamine; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Phospholipids; Rabbits; Spectrophotometry; Time Factors | 1979 |
Electrochemical investigations on the oxygen activation by cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Polarography; Rabbits | 1979 |
Direct evidence that an arene oxide is a metabolic intermediate of 2,2',5,5'-tetrachlorobiphenyl.
Topics: Animals; Epoxy Compounds; Ethers, Cyclic; Male; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Rats; Tritium | 1979 |
Factors influencing the microsome- and mitochondria-catalyzed in vitro binding of diethylnitrosamine and N-nitrosopiperidine to deoxyribonucleic acid.
Topics: Animals; Cytosol; Diethylnitrosamine; DNA; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Nitrosamines; Phenobarbital; Piperidines; Rats | 1979 |
Significance of enzyme induction to clinical anesthesia.
Topics: Anesthetics; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dicumarol; Enzyme Induction; Humans; Kidney; Liver; Microsomes; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Phenobarbital | 1975 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
The electron transfer in the membranes of endoplasmic reticulum. A quantitative estimation of cytochrome b5 content in the NADPH- and NADH-oxidation chains.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport; Endoplasmic Reticulum; Liver; Membranes; NAD; NADP; Phenobarbital; Rats; Spectrophotometry | 1975 |
In vitro hepatic and extra-hepatic reduction of (minus)-nicotine-1'-N-oxide in rats.
Topics: Anaerobiosis; Animals; Carbon Monoxide; Chromatography, Gas; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Digestive System; Duodenum; Edetic Acid; Flavins; Gastric Mucosa; Ileum; In Vitro Techniques; Intestines; Kidney; Kinetics; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mitochondria, Liver; Myocardium; NADH, NADPH Oxidoreductases; NADP; Nicotine; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Proadifen; Proteins; Rats | 1975 |
Biphenyl hydroxylations and spectrally apparent interactions with liver microsomes from hamsters pre-treated with phenobarbitone and 3-methylcholanthrene.
Topics: Alcohols; Animals; Biphenyl Compounds; Carbon Radioisotopes; Cricetinae; Cytochrome P-450 Enzyme System; Cytochromes; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Phenobarbital | 1975 |
Microsomal ethanol oxidation: activity in vitro and in vivo.
Topics: Animals; Azides; Carbon Monoxide; Catalase; Cyanides; Ethanol; Hydrogen Peroxide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Pyrazoles; Rats | 1975 |
Evidence for the formation of a protein bound hydrodisulfide resulting from the microsomal mixed function oxidase catalyzed desulfuration of carbon disulfide.
Topics: Animals; Carbon Disulfide; Chromatography, Gel; Cyanides; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Thiocyanates | 1975 |
Drug metabolism in isolated rat liver cells.
Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium | 1975 |
Dissociation of microsomal ethanol oxidation from cytochrome P-450 catalyzed drug metabolism.
Topics: Age Factors; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Catalase; Cell Fractionation; Cytochrome P-450 Enzyme System; Ethanol; Female; Lipid Metabolism; Male; Mice; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Nitroanisole O-Demethylase; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital | 1975 |
Interaction between microsomal electron transfer pathways.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Cytochrome Reductases; Cytochromes; Electron Transport; Ethylmorphine-N-Demethylase; Fatty Acids; Hexobarbital; Lipid Metabolism; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Peroxidases; Phenobarbital; Rats; Spectrum Analysis; Stearoyl-CoA Desaturase | 1975 |
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Antioxidants; Castration; Dietary Proteins; Electron Transport; Haplorhini; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Selenium; Time Factors; Vitamin E; Vitamin E Deficiency | 1975 |
The effects of halothane on hepatic microsomal electron transfer.
Topics: Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Electron Transport Complex IV; Halothane; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Stearoyl-CoA Desaturase | 1975 |
Sodium periodate, sodium chloride, organic hydroperoxides, and H2O2 as hydroxylating agents in steroid hydroxylation reactions catalyzed by partially purified cytochrome P-450.
Topics: Androstenedione; Animals; Chlorine; Cytochrome P-450 Enzyme System; Hydrogen Peroxide; Kinetics; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Periodic Acid; Peroxides; Phenobarbital; Rats; Steroid Hydroxylases | 1975 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Aryl hydrocarbon hydroxylase in liver nuclei of C3H/He and DBA/2 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Cyclohexanes; Endoplasmic Reticulum; Epoxide Hydrolases; Female; Flavonoids; Glucose-6-Phosphatase; Liver; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Microsomes, Liver; NAD; NADP; Niacinamide; Nucleotidases; Phenobarbital; Propane | 1975 |
The p-hydroxylation of amphetamine and phentermine by rat liver microsomes.
Topics: Amphetamine; Aniline Hydroxylase; Animals; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Phentermine; Rats | 1975 |
Spin-labeling studies of rat liver NADPH-cytochrome p450 reductase: conformation and function relationship.
Topics: Acetylation; Animals; Binding Sites; Dithiothreitol; Electron Spin Resonance Spectroscopy; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Kinetics; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Potassium Chloride; Protein Binding; Protein Conformation; Rats; Rats, Inbred Strains | 1992 |
Fate of isopropyl-iodoamphetamine (IMP) in rat liver microsomes.
Topics: Amphetamines; Animals; Biotransformation; Cytochrome P-450 Enzyme System; In Vitro Techniques; Iofetamine; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Sprague-Dawley | 1992 |
In vitro metabolism and bioactivation of 1,2,3-trichloropropane.
Topics: Acetone; Animals; Biotransformation; Cytosol; Humans; Male; Microsomes, Liver; NADP; Phenobarbital; Propane; Rats; Rats, Inbred Strains | 1992 |
Exocyclic-keto reductase activities for progesterone and S-warfarin in hepatic microsomes from adult male rats.
Topics: 20-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Animals; Cytochrome P-450 Enzyme System; Female; Male; Microsomes, Liver; NAD; NADP; Phenobarbital; Progesterone; Rats; Rats, Inbred Strains; Sex Characteristics; Species Specificity; Warfarin | 1992 |
NADPH-dependent reduction of amaranch in liver microsomes characterized the quantity of low spin forms of cytochrome P-450.
Topics: Amaranth Dye; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fomepizole; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Safrole | 1991 |
Participation of phenobarbital-inducible cytochrome P450 in the mutagenic activation of N-nitrosopropylamines by liver and lung 9000 g fractions from five animal species and man.
Topics: Animals; Biotransformation; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Liver; Lung; Mice; Mutagens; NADP; Nitrosamines; Phenobarbital; Rats | 1991 |
Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital-inducible cytochrome P450s.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Cell Line; Cricetinae; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Male; Methods; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Umbelliferones | 1991 |
[The effect of cofactors on microsomal S-oxygenation of oxyprothepine].
Topics: Animals; Dibenzothiepins; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.
Topics: Animals; Cyclic N-Oxides; Enzyme Induction; Kidney; Liver; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen Oxides; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Spin Labels | 1991 |
The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Halothane; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Spectrum Analysis | 1991 |
Metabolism of nitroxide spin labels in subcellular fraction of rat liver. I. Reduction by microsomes.
Topics: Animals; Cyclic N-Oxides; Cytochromes b5; Hydroxylamines; Kinetics; Male; Microsomes, Liver; NAD; NADH Dehydrogenase; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains; Spin Labels | 1990 |
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
Topics: Animals; Biotransformation; Catalase; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits; Safrole; Smoke; Superoxide Dismutase; Superoxides | 1990 |
Reduced glucose-6-phosphorylase and NADPH generating enzyme activities associated with glibenclamide induced hypoglycemia and hypoinsulinemia in genetically obese mice.
Topics: Animals; Antiporters; Endoplasmic Reticulum; Female; Glucosephosphate Dehydrogenase; Glyburide; Hypoglycemia; Insulin; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Microsomes; Monosaccharide Transport Proteins; NADP; Phenobarbital; Phosphotransferases; Proteins | 1990 |
Hepatic catecholestrogen synthases: differential effect of sex, inducers of cytochromes P-450 and of antibody to the glucocorticoid inducible cytochrome P-450 on NADPH-dependent estrogen-2-hydroxylase and on organic hydroperoxide-dependent estrogen-2/4-hy
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Estradiol; Estrogens, Catechol; Female; Isoniazid; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1990 |
Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules.
Topics: Acridines; Animals; Cytochrome P-450 Enzyme System; Diagnostic Imaging; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Luminescent Measurements; Luminol; Microsomes, Liver; NADP; Oxygen; Oxygenases; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
In vitro metabolism of the antianxiety drug buspirone as a predictor of its metabolism in vivo.
Topics: Animals; Buspirone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Hydroxylation; Liver; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains | 1990 |
Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1990 |
Metabolism of methacrylonitrile to cyanide: in vitro studies.
Topics: Animals; Biotransformation; Cyanides; Cytochrome P-450 Enzyme System; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methacrylates; Microsomes, Liver; NADP; Nitriles; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
NADPH- and adriamycin-dependent microsomal release of iron and lipid peroxidation.
Topics: Animals; Catalase; Cytochrome P-450 Enzyme System; Doxorubicin; Iron; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Glycolates; Hydroxylation; Isomerism; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Thiophenes; Ticrynafen | 1990 |
Metabolism of ciamexon by human liver microsomes: an investigation into the formation of stable, chemically reactive and cytotoxic metabolites.
Topics: Animals; Aziridines; Biotransformation; Cell Survival; Chromatography, High Pressure Liquid; Humans; Hydroxylation; In Vitro Techniques; Male; Mice; Microsomes, Liver; Monocytes; NADP; Phenobarbital; Rats; Species Specificity | 1990 |
Vitamin E and glutathione are required for preservation of microsomal glutathione S-transferase from oxidative stress in microsomes.
Topics: Animals; Antioxidants; Bromotrichloromethane; Chloroform; Glutathione; Glutathione Transferase; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Sulfobromophthalein; Vitamin E | 1990 |
Microsomal metabolism of carbon tetrachloride: participation of pyridine nucleotide synergism.
Topics: Animals; Carbon Tetrachloride; In Vitro Techniques; Lipid Peroxidation; Male; Microsomes, Liver; NAD; NADP; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains | 1990 |
Modifications of hepatic microsomal 9-oxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Castration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; Glucuronidase; Glucuronosyltransferase; Hydroxylation; Male; Microsomes, Liver; NADH Dehydrogenase; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Isoenzymes; Male; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
N-oxygenation of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent: the role of flavin-containing monooxygenase.
Topics: Animals; Anti-Arrhythmia Agents; Flavins; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Male; Methimazole; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Oxygen; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains | 1989 |
7-ethenyloxycoumarin as a new substrate for fluorophotometric assay of hepatic microsomal epoxidizing activities.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spectrophotometry; Umbelliferones | 1989 |
Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Topics: Amino Acid Sequence; Animals; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Immunoblotting; Immunoglobulin G; Kinetics; Male; Microsomes, Liver; Molecular Sequence Data; Molecular Weight; NADP; Phenobarbital; Rats; Spectrophotometry; Steroid Hydroxylases; Troleandomycin | 1989 |
Cytochrome P-450-dependent formation of alkylating metabolites of the 2-chloroethylnitrosoureas MeCCNU and CCNU.
Topics: Acetylcysteine; Alkylating Agents; Alkylation; Animals; Biotransformation; Cytochrome P-450 Enzyme System; DNA; Glutathione; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred F344; Semustine | 1989 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Karyotyping; Liver Neoplasms, Experimental; Methylcholanthrene; NADP; Neoplasm Transplantation; Organoids; Phenobarbital; Phenotype; Rats; Tyrosine Transaminase | 1986 |
Adriamycin-dependent release of iron from microsomal membranes.
Topics: Animals; Doxorubicin; Free Radicals; Intracellular Membranes; Iron; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Regulation of corticosterone metabolism in liver cell fractions in young and adult rats: cofactor requirements, effects of stress and phenobarbital treatment.
Topics: Aging; Animals; Chemical Fractionation; Coenzymes; Corticosterone; Liver; Male; NAD; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Stress, Physiological; Tissue Distribution | 1987 |
Medroxyprogesterone acetate (MPA) enhances liver NADPH-generating enzyme activities in normal rats.
Topics: Animals; Glucosephosphate Dehydrogenase; Isocitrate Dehydrogenase; Liver; Malate Dehydrogenase; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; NADP; NADPH-Ferrihemoprotein Reductase; Organ Size; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Rats, Inbred Strains | 1988 |
Effect of inhibitors of alpha-naphthylisothiocyanate-induced hepatotoxicity on the in vitro metabolism of alpha-naphthylisothiocyanate.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Aminopyrine; Animals; Bilirubin; Biotransformation; Chromatography, Gas; Ditiocarb; Ethionamide; Hyperbilirubinemia; Imidazoles; Kinetics; Male; Methimazole; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Thiocyanates | 1985 |
Medroxyprogesterone acetate and phenobarbital induce NADPH producing enzyme activities in rats with a chemical liver injury.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Induction; Glucose-6-Phosphatase; Isocitrate Dehydrogenase; Malate Dehydrogenase; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; NADP; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Rats, Inbred Strains | 1985 |
Reconstitution of liver monooxygenase system in solution from cytochrome P-450 and NADPH-specific flavoprotein monomers.
Topics: Animals; Cytochrome P-450 Enzyme System; Flavoproteins; Isoenzymes; Kinetics; Male; Mathematics; Microsomes, Liver; NADP; Nonoxynol; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Polyethylene Glycols; Rabbits | 1986 |
In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Etoposide; Mice; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Proadifen; Proteins | 1987 |
Metabolic activation of hydralazine by rat liver microsomes.
Topics: Animals; Biotransformation; Electron Spin Resonance Spectroscopy; Hydralazine; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains | 1987 |
Hydroxyl-radical production and ethanol oxidation by liver microsomes isolated from ethanol-treated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Ethanol; Free Radicals; Hydroxides; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Malic enzyme levels are increased by the activation of NADPH-consuming pathways: detoxification processes.
Topics: Adipose Tissue; Animals; Carmustine; Enzyme Activation; Female; Glutathione Reductase; Immunochemistry; Inactivation, Metabolic; Malate Dehydrogenase; NADP; NADPH-Ferrihemoprotein Reductase; Peroxides; Phenobarbital; Rats; Rats, Inbred Strains; tert-Butylhydroperoxide | 1986 |
Influence of N,N-dimethylaniline on the association of phenobarbital-induced cytochrome P-450 and NADPH-cytochrome c(P-450) reductase in a reconstituted rabbit liver microsomal enzyme system.
Topics: Aniline Compounds; Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescence Polarization; Fluorescent Dyes; Kinetics; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Spectrometry, Fluorescence; Thiocyanates | 1987 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
Protein-protein and lipid-protein interactions in a reconstituted cytochrome P-450 dependent microsomal monooxygenase.
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rats; Thermodynamics | 1987 |
Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Cholic Acid; Cholic Acids; Cytochrome P-450 Enzyme System; Cytosol; Liver; Male; Methylcholanthrene; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital; Propane; Quinone Reductases; Rats; Rats, Inbred Strains | 1988 |
Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. IX. A comparative study with enantiomeric 2-nitroso-1-phenylpropane in microsomes and a reconstituted cytochrome P-450 system from rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Male; Microsomes, Liver; NADP; Nitroso Compounds; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1988 |
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Lipid Metabolism; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Pyridines; Rats; Rats, Inbred Strains; Triiodothyronine | 1988 |
The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450.
Topics: Animals; Cells, Cultured; Cyclosporins; Cytochrome P-450 Enzyme System; Kinetics; Macromolecular Substances; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1987 |
Maintenance of nicotinamide dinucleotide phosphate content and oxidation-reduction state during mixed-function oxidation of p-nitroanisole in isolated perfused livers of various species.
Topics: Animals; Anisoles; Cricetinae; Female; Kinetics; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
[The role of vitamin K3 in the hydroxylation of benz(a)pyrene in rat liver mitochondria after induction with 3-methylcholanthrene and phenobarbital].
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Vitamin K | 1987 |
Hexachlorobenzene-induced oxygen activation by mouse liver microsomes: comparison with phenobarbitone and 20-methylcholanthrene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxygen; Phenobarbital | 1987 |
Interactions of diethylphenylphosphine with purified, reconstituted mouse liver cytochrome P-450 monooxygenase systems.
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male; Mice; Mice, Inbred ICR; NADP; Organophosphorus Compounds; Oxidation-Reduction; Oxygenases; Phenobarbital | 1986 |
NADPH-dependent and -independent loss of cytochrome P-450 in control and phenobarbital-induced rat hepatic microsomes incubated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Cytochrome P-450 mediated reductive dehalogenation of the perhalogenated aromatic compound hexachlorobenzene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hexachlorobenzene; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Metabolic activation of the tricyclic antidepressant amineptine--I. Cytochrome P-450-mediated in vitro covalent binding.
Topics: Animals; Antidepressive Agents, Tricyclic; Biotransformation; Cricetinae; Cytochrome P-450 Enzyme System; Dibenzocycloheptenes; Kidney; Kinetics; Lung; Male; Mesocricetus; Microsomes; Microsomes, Liver; NADP; Phenobarbital | 1987 |
Metabolic activation of the tricyclic antidepressant amineptine--II. Protective role of glutathione against in vitro and in vivo covalent binding.
Topics: Animals; Antidepressive Agents, Tricyclic; Biotransformation; Buthionine Sulfoximine; Cricetinae; Dibenzocycloheptenes; Glutathione; Ketones; Kinetics; Male; Mesocricetus; Methionine Sulfoximine; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide | 1987 |
Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethers, Cyclic; Isoenzymes; Male; Mathematics; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
In vitro metabolism of ACNU, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitroso urea hydrochloride, a water-soluble antitumor nitrosourea.
Topics: Animals; Antineoplastic Agents; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Microsomes, Liver; NADP; Nimustine; Nitrosourea Compounds; Phenobarbital; Proadifen; Rats; Temperature; Time Factors | 1985 |
A new monooxygenase product from 7-ethoxycoumarin and its relation to the O-dealkylation reaction.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Coumarins; Cytochrome b Group; Cytochromes b5; Enzyme Induction; Hydroxylation; Isoenzymes; Mice; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Oxygenases; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Substrate Specificity; Swine; Time Factors | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
The metabolism of 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in the rat in vivo and in vitro.
Topics: Animals; Appetite Depressants; Biotransformation; Carbon Monoxide; Chromatography, Gas; Chromatography, Thin Layer; Furans; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene.
Topics: Animals; Aroclors; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Chlorophenols; Chromatography, High Pressure Liquid; Female; Hexachlorobenzene; Male; Methylcholanthrene; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
Effect of the antioxidant (+)-cyanidanol-3 on H2O2 formation and lipid peroxidation in liver microsomes.
Topics: Animals; Benzopyrans; Catechin; Female; Guinea Pigs; Humans; Hydrogen Peroxide; In Vitro Techniques; Lipid Peroxides; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
New pathway for retinol metabolism in liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Vitamin A | 1985 |
In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone.
Topics: Administration, Oral; Animals; Cyclohexane Monoterpenes; Cytochrome P-450 Enzyme System; Kinetics; Male; Menthol; Methylcholanthrene; Microsomes, Liver; Monoterpenes; NADP; Phenobarbital; Rats; Time Factors | 1985 |
The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins.
Topics: Animals; Ascorbic Acid; Biotransformation; Cytochrome P-450 Enzyme System; Etoposide; HeLa Cells; Humans; In Vitro Techniques; Microsomes; Microsomes, Liver; NADP; Neoplasm Proteins; Nitrogen Oxides; Phenobarbital; Podophyllotoxin; Proadifen; Protein Binding; Pyridines; Rats; Rats, Inbred Strains | 1985 |
Effect of dietary vitamin E on methyl ethyl ketone peroxide damage to microsomal cytochrome P-450 peroxidase.
Topics: Animals; Butanones; Cytochrome P-450 Enzyme System; Diet; Glutathione Peroxidase; Glutathione Transferase; Hemeproteins; Lipid Peroxides; Male; Microsomes, Liver; NADP; Peroxidases; Peroxides; Phenobarbital; Rats; Rats, Inbred Strains; Vitamin E | 1985 |
Characteristics of nitro reduction of the carcinogenic agent, 4-nitroINOLONE N-oxide.
Topics: Alcohol Oxidoreductases; Animals; Benzoates; Carcinogens; Dicumarol; Flavin Mononucleotide; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Oxides; Oxidoreductases; Oxygen; Phenobarbital; Quinolines; Rats; Time Factors | 1970 |
Immunochemical studies on electron transport chains involving cytochrome P-450. I. Effects of antibodies to pig liver microsomal reduced triphosphopyridine nucleotide-cytochrome c reductase and the non-heme iron protein from bovine adrenocortical mitochon
Topics: Adrenal Glands; Animals; Antibodies; Antigen-Antibody Reactions; Cattle; Chromatography, DEAE-Cellulose; Cytochromes; Electron Transport; Female; Ferredoxins; gamma-Globulins; Immune Sera; Immunochemistry; Immunodiffusion; Immunoglobulins; Male; Microsomes; Microsomes, Liver; Mitochondria; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rabbits; Rats; Swine | 1971 |
Metabolism of dicoumarol by liver microsomes from untreated and phenobarbital treated rats.
Topics: Animals; Atmosphere; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dicumarol; Male; Microsomes, Liver; Mitochondria, Liver; NAD; NADP; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Time Factors | 1972 |
The role of liver microsomal enzymes in the metabolism of parathion.
Topics: Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Female; In Vitro Techniques; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; NAD; NADP; Osmium; Oxidation-Reduction; Paraoxon; Parathion; Pesticide Residues; Phenobarbital; Proteins; Rats; Staining and Labeling | 1973 |
Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.
Topics: Animals; Carbon Monoxide; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Activation; Enzyme Induction; Female; Fluorescence; Indophenol; Jejunum; Light; Liver; Mice; Microsomes; Monoamine Oxidase; NADP; Oxidoreductases; Phenobarbital; Stimulation, Chemical | 1973 |
Oxidative drug metabolism in the perinatal rabbit liver and placenta. A biochemical and morphologic study.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzopyrenes; Cytochrome Reductases; Electron Transport; Endoplasmic Reticulum; Female; Gestational Age; Hydroxylation; Liver; Methylation; Microscopy, Electron; Microsomes; Microsomes, Liver; NAD; NADP; Phenobarbital; Placenta; Pregnancy; Rabbits; Species Specificity | 1973 |
Kinetics of CO and O 2 complexes of rabbit liver microsomal cytochrome P 450 .
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Kinetics; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Photolysis; Protein Binding; Rabbits; Time Factors | 1973 |
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats | 1973 |
N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans.
Topics: Animals; Carbon Monoxide; Dapsone; Dogs; Erythrocytes; Female; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hydroxylation; Male; Methemoglobin; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Proteins; Rabbits; Time Factors | 1973 |
Microsomal electron transport. I. Reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and cytochrome P-450 as electron carriers in microsomal NADPH-peroxidase activity.
Topics: Adrenal Glands; Animals; Cattle; Cyanides; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Hydrogen-Ion Concentration; Immune Sera; Kinetics; Male; Microsomes; Microsomes, Liver; NAD; NADP; Organ Specificity; Osmolar Concentration; Oxidoreductases; Peroxidases; Peroxides; Phenobarbital; Rabbits; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Steroids; Trypsin | 1973 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.
Topics: Acetates; Aniline Compounds; Animals; Calcium; Depression, Chemical; Edetic Acid; Formaldehyde; Glycols; Kinetics; Magnesium; Male; Methylation; Microsomes, Liver; NADP; Niacinamide; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Species Specificity; Stimulation, Chemical; Sulfhydryl Reagents; Swine | 1973 |
Effects of Triton X-100 on drug hydroxylation system of rat liver microsomes induced by phenobarbital or 3-methylcholanthrene.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Enzyme Activation; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Surface-Active Agents | 1972 |
The early stage of labeling of microsomal membrane proteins in rat liver by radioactive amino acids.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Membrane; Cycloheximide; Cytochrome c Group; Cytochrome Reductases; Guanidines; Leucine; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Puromycin; Rats | 1972 |
Digitoxigenin metabolism by rat liver microsomes and its induction by phenobarbital.
Topics: Animals; Cardanolides; Glucosephosphate Dehydrogenase; Glucosephosphates; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Phenylbutazone; Proteins; Rats; Tritium | 1973 |
Induction of liver microsomal drug metabolism in newly-hatched chicks.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Animals, Newborn; Chick Embryo; Chickens; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Phenobarbital; Time Factors | 1973 |
Effect of excess and deficient copper intake on rat liver microsomal enzyme activity.
Topics: Age Factors; Aniline Compounds; Animals; Benzopyrenes; Copper; Diet; Female; Glucose-6-Phosphatase; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Phosphates; Rats; Sleep | 1973 |
Omega-hydroxylation of steriod side-chain in biosynthesis of bile acids.
Topics: Animals; Bile Acids and Salts; Carbon Monoxide; Chenodeoxycholic Acid; Cholestanes; Cholestenes; Cholesterol; Hydroxylation; Male; Microsomes, Liver; Mitochondria, Liver; NAD; NADP; Phenobarbital; Rats; Starvation; Steroid Hydroxylases | 1973 |
Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Charcoal; Chromatography, Gel; Chromatography, Ion Exchange; Endoplasmic Reticulum; Estradiol; Ethinyl Estradiol; Female; Hydroxylation; Male; Microsomes, Liver; NADP; Peptide Fragments; Phenobarbital; Proadifen; Protein Binding; Proteins; Rats; Serum Albumin, Bovine; Time Factors; Tritium; Trypsin | 1973 |
Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.
Topics: Aminopyrine N-Demethylase; Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen; Oxidoreductases; Phenobarbital; Rats; Riboflavin Deficiency | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium | 1973 |
Reduction of ketones in liver cytosol.
Topics: Acetone; Acetophenones; Animals; Benzophenones; Chromatography, Gas; Chromatography, Thin Layer; Cytosol; Ketone Oxidoreductases; Ketones; Kidney; Liver; Lung; Male; Myocardium; NAD; NADP; Phenobarbital; Rabbits; Rats | 1971 |
Is phenobarbital a "gratuitous" inducer in male rats?
Topics: Aminopyrine N-Demethylase; Animals; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Phosphatidylcholines; Rats | 1973 |
Effect of temperature on the mixed function oxidase-catalyzed metabolism of O,O-diethyl p-nitrophenyl phosphorothionate (parathion).
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Organothiophosphorus Compounds; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Rats; Temperature | 1973 |
Electron transport components of hepatic microsomes. Solubilization, resolution, and recombination to reconstitute aniline hydroxylase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Chloromercuribenzoates; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats; Solubility; Structure-Activity Relationship; Vitamin K | 1973 |
Activity of horse liver alcohol dehydrogenase SS with NADP (H) as coenzyme and its sensitivity to barbiturates.
Topics: Alcohol Oxidoreductases; Ammonium Sulfate; Animals; Barbiturates; Chromatography, DEAE-Cellulose; Dihydrotestosterone; Horses; In Vitro Techniques; Kinetics; Liver; NADP; Oxidation-Reduction; Pentobarbital; Phenobarbital | 1973 |
Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction.
Topics: Aminopyrine; Animals; Azides; Catalase; Cytochrome P-450 Enzyme System; Hemeproteins; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1973 |
Histochemical changes in developing mouse liver after administration of phenobarbital.
Topics: Animals; Cell Differentiation; Cytoplasm; Dihydrolipoamide Dehydrogenase; Endoplasmic Reticulum; Female; Gestational Age; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Histocytochemistry; Injections, Intraperitoneal; Liver; Mice; NADP; Phenobarbital; Pregnancy | 1973 |
Evidence against participation of cytochrome b5 in the hepatic microsomal mixed-function oxidase reaction.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome c Group; Cytochrome Reductases; Cytochromes; Dealkylation; In Vitro Techniques; Male; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Protein Binding; Rats; Spectrophotometry, Ultraviolet; Surface-Active Agents; Time Factors | 1973 |
Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro.
Topics: Aldehyde Oxidoreductases; Amobarbital; Animals; Anticonvulsants; Barbiturates; Brain; Cattle; Ethosuximide; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerism; Kinetics; Mephobarbital; NADP; Pentobarbital; Phenobarbital; Phenytoin; Spectrometry, Fluorescence; Spectrophotometry; Succinimides; Trimethadione | 1973 |
Benzene metabolism in mouse liver microsomes.
Topics: Animals; Benzene; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Tritium | 1973 |
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.
Topics: Animals; Depression, Chemical; Ethanol; Humans; Hydrocortisone; Injections, Intraperitoneal; Kynurenine; Liver; NAD; NADP; Phenobarbital; Rats; Sodium Chloride; Sodium Salicylate; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
The rôle of cytochrome P-450 in cholesterol biosynthesis.
Topics: Adenosine Triphosphate; Animals; Carbon Monoxide; Carbon Radioisotopes; Cholesterol; Cytochrome P-450 Enzyme System; Lanosterol; Light; Male; Microsomes, Liver; NADP; Nitrogen; Oxygen; Phenobarbital; Rats | 1973 |
Effects of phenobarbital administration on rates of ethanol clearance and on ethanol-oxidizing enzymes in man.
Topics: Adipates; Adult; Alcohol Oxidoreductases; Biopsy; Ethanol; Humans; Liver; Male; NADP; Phenobarbital; Proteins; Sugar Acids | 1974 |
Interaction of mixed-function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver.
Topics: Acetone; Aminopyrine; Animals; Depression, Chemical; Flavins; Fluorometry; Gluconeogenesis; In Vitro Techniques; Kinetics; Lactates; Liver; Male; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Perfusion; Phenobarbital; Rats | 1973 |
Response of the mixed function oxidase system of rat hepatic microsomes to parathion and malathion and their oxygenated analogs.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Activation; Hydroxylation; In Vitro Techniques; Malathion; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Oxidoreductases, N-Demethylating; Paraoxon; Parathion; Phenobarbital; Protein Binding; Rats; Spectrophotometry, Ultraviolet | 1973 |
Effect of riboflavin deficiency on liver microsomal enzyme system and lipid peroxidation in male rats.
Topics: Animals; Ascorbic Acid; Cytochrome c Group; Cytochrome Reductases; Cytochromes; Lipid Metabolism; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Riboflavin Deficiency | 1973 |
Oxidative metabolism of carbon disulphide by the rat. Effect of treatments which modify the liver toxicity of carbon disulphide.
Topics: Animals; Carbon Dioxide; Carbon Disulfide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Edetic Acid; Fasting; Female; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Time Factors | 1973 |
Lipid peroxidation and the degradation of cytochrome P-450 heme.
Topics: Aminopyrine; Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Levulinic Acids; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Pentobarbital; Peroxidases; Phenobarbital; Protein Binding; Rats; Secobarbital; Spectrophotometry; Time Factors; Tritium | 1973 |
Preparation of partially purified, lipid-depleted cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rat liver microsomes.
Topics: Animals; Cholic Acids; Chromatography, DEAE-Cellulose; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Detergents; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Rats; Spectrophotometry; Ultrafiltration | 1974 |
Abnormal microsomal cytochromes and electron transport in Morris hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Fractionation; Cell Line; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Flavoproteins; Hemeproteins; Liver; Liver Neoplasms; Microscopy, Electron; Microsomes; NAD; NADH, NADPH Oxidoreductases; NADP; Neoplasms, Experimental; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Spectrophotometry | 1974 |
Studies on selenium incorporation into, and electron-transfer function of, liver microsomal fractions from normal and vitamin E-deficient rats given phenobarbitone.
Topics: Animals; Blood Proteins; Centrifugation, Zonal; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport; Endoplasmic Reticulum; Liver; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Proteins; Radioisotopes; Rats; Selenium; Vitamin E Deficiency | 1973 |
Studies on the metabolism of ethynylestradiol in vitro and in vivo: the significance of 2-hydroxylation and the formation of polar products.
Topics: Animals; Carbon Monoxide; Chromatography; Chromatography, Thin Layer; Estradiol; Estrone; Ethinyl Estradiol; Glutathione; Hydroxylation; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Silicon Dioxide; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Microsomal enzyme activity in perfused rat liver.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Nicotinic Acids; Perfusion; Phenobarbital; Proteins; Rats; Time Factors | 1974 |
Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A.
Topics: Acetaminophen; Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Dealkylation; Dialysis; Dogs; Half-Life; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Phenacetin; Phenazines; Phenobarbital; Proadifen; Proteins | 1974 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes.
Topics: Animals; Antineoplastic Agents; Carbon Monoxide; Chromatography, Ion Exchange; Cyclohexanes; Hydroxylation; Kinetics; Male; Mass Spectrometry; Microsomes, Liver; NADP; Nitrosourea Compounds; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes.
Topics: Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electrophoresis, Polyacrylamide Gel; Immunoglobulins; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rabbits; Rats | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
Studies of the metabolism of carbon disulfide by rat liver microsomes.
Topics: Animals; Binding Sites; Carbon Disulfide; Carbon Radioisotopes; Chromatography, Gas; Mass Spectrometry; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Sulfur Radioisotopes | 1974 |
Studies of the binding of sulfur released in the mixed-function oxidase-catalyzed metabolism of diethyl p-nitrophenyl phosphorothionate(parathion) to diethyl p-nitrophenyl phosphate (paraoxon).
Topics: Animals; Benzphetamine; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dealkylation; Esterases; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Solvents; Sulfur; Sulfur Radioisotopes | 1974 |
Proceedings: Evidence for oxidative metabolism of metyrapone in rat liver microsomes.
Topics: Animals; Chromatography, Thin Layer; In Vitro Techniques; Kinetics; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
Oxidation of barbiturates and the glucuronidation of 1-napthol in perfused rat liver and in microsomes.
Topics: Animals; Barbiturates; Biotransformation; Carbon Radioisotopes; Glucuronates; Half-Life; Hexobarbital; Hexosyltransferases; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; NADP; Naphthols; Oxidation-Reduction; Perfusion; Phenobarbital; Rats | 1974 |
Riboflavin and drug metabolism in adult male and female rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Body Weight; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Electron Transport; Female; In Vitro Techniques; Liver; Male; Microsomes, Liver; Morphinans; NADP; Organ Size; Phenobarbital; Proteins; Rats; Riboflavin Deficiency; Sex Factors; Time Factors | 1974 |
A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.
Topics: Adenosine Triphosphate; Alprenolol; Animals; Antimycin A; Cell Survival; Cyanides; Cytochrome P-450 Enzyme System; Cytoplasm; Gluconeogenesis; Histocytochemistry; In Vitro Techniques; Lactates; Liver; Malate Dehydrogenase; Male; Metyrapone; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Pentosephosphates; Phenobarbital; Rats; Rotenone; Spectrophotometry; Starvation; Uncoupling Agents | 1974 |
Studies on the biogenesis of smooth endoplasmic reticulum membranes in hepatocytes of phenobarbital-treated rats. II. The site of phospholipid synthesis in the initial phase of membrane proliferation.
Topics: Acyltransferases; Animals; Carbon Radioisotopes; Cell Division; Cytochrome Reductases; Dactinomycin; Dihydrolipoamide Dehydrogenase; Endoplasmic Reticulum; Glycerol; Liver; Male; Membranes; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Proteins; Puromycin; Rats; Time Factors | 1974 |
The role of NADH in uncoupled microsomal monoxygenations.
Topics: Alkanes; Animals; Cyclohexanes; Cyclohexanols; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ethanol; Hexanols; Hydrocarbons, Fluorinated; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Oxygenases; Phenobarbital; Rabbits; Spectrometry, Fluorescence; Uncoupling Agents | 1974 |
In vitro induction by phenobarbital of drug monooxygenase activity in mouse isolated small intestine.
Topics: Animals; Carbon Radioisotopes; Coumarins; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dactinomycin; Dealkylation; Enzyme Induction; Fluorometry; Hydrogen-Ion Concentration; Intestinal Mucosa; Jejunum; Leucine; Male; Mice; Microsomes; NADP; Oxygenases; Perfusion; Phenobarbital; Puromycin; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Oxidative metabolism of aflatoxin B1 by rat liver microsomes in vitro and its effect on lipid peroxidation.
Topics: Adenosine Diphosphate; Aflatoxins; Animals; Ascorbic Acid; Aspergillus flavus; Chromatography, Thin Layer; Edetic Acid; In Vitro Techniques; Lipid Metabolism; Lipids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Peroxides; Phenobarbital; Proadifen; Rats; Spectrophotometry, Ultraviolet | 1974 |
The effect of extra bound cytochrome b-5 on cytochrome P-450-dependent enzyme activities in liver microsomes.
Topics: Anaerobiosis; Animals; Benzphetamine; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Kinetics; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Peroxidases; Phenobarbital; Rabbits; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Ultracentrifugation | 1974 |
Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver.
Topics: Allylisopropylacetamide; Aniline Compounds; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dicarboxylic Acids; Female; Heme; Iron Radioisotopes; Kinetics; Leucine; Lipid Metabolism; Liver; Mice; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Organ Size; Phenobarbital; Phospholipids; Protein Biosynthesis; Pyridines; Ribonucleases; RNA | 1974 |
Highly purified detergent-solubilized NADPH-cytochrome P-450 reductase from phenobarbital-induced rat liver microsomes.
Topics: Animals; Binding Sites; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Deoxycholic Acid; Detergents; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydroxyapatites; Microsomes, Liver; Molecular Weight; NADP; Oxidation-Reduction; Phenobarbital; Protein Binding; Rabbits; Rats; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet | 1974 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
Hydroxylations of bile acids by reconstituted systems from rat liver microsomes.
Topics: Animals; Bile Acids and Salts; Carbon Radioisotopes; Cattle; Chenodeoxycholic Acid; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Deoxycholic Acid; Drug Stability; Erythrocytes; Female; Freezing; Lithocholic Acid; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Phenobarbital; Phosphatidylcholines; Rats; Sex Factors; Superoxide Dismutase; Taurine; Time Factors; Tritium; Ultracentrifugation | 1974 |
Low temperature studies of microsomal cytochrome P450. Release of oxidizing species.
Topics: Animals; Cold Temperature; Cytochrome P-450 Enzyme System; Drug Stability; Male; Microsomes, Liver; NADP; Nitrogen; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Spectrophotometry; Time Factors | 1974 |
[Obtaining microsomes by coprecipitation with Ca2+ and demonstration of enzyme induction using phenobarbital].
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Butylated Hydroxytoluene; Cytological Techniques; Enzyme Induction; Glucosephosphates; Liver; Male; Microsomes; NADP; Oxidoreductases; Phenobarbital; Rats | 1973 |
Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA.
Topics: Aflatoxins; Animals; Benzopyrans; Benzopyrenes; Binding Sites; Carbon Radioisotopes; DNA; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Spectrum Analysis; Tritium | 1974 |
[Inactivation of microsomal proteins by lysosomes (author's transl)].
Topics: Animals; Cell Fractionation; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Cytochromes; Endoplasmic Reticulum; Enzyme Induction; Female; Hydrogen-Ion Concentration; Kinetics; Liver; Lysosomes; Membranes; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Ultracentrifugation | 1973 |
Metabolic interconversions and binding of imipramine, imipramine-N-oxide, and desmethylimipramine in rat liver slices.
Topics: Animals; Cytosol; Dealkylation; Desipramine; Female; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Sex Factors; Temperature; Time Factors | 1971 |
Relationship between reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation and drug hydroxylation in rat liver microsomes.
Topics: Animals; Ascorbic Acid; Benzopyrenes; Hydroxylation; In Vitro Techniques; Lipid Metabolism; Lipids; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Peroxides; Pharmaceutical Preparations; Phenobarbital; Rats | 1974 |
Effect of phenobarbital on the incorporation of 3H or 14C labeled precursors into fatty acids.
Topics: Acetates; Animals; Carbon Radioisotopes; Cytochrome Reductases; Endoplasmic Reticulum; Fatty Acids; Female; Glucose; Glucosephosphate Dehydrogenase; Hydrogenation; L-Lactate Dehydrogenase; Liver; Malonates; NADP; Oxidation-Reduction; Phenobarbital; Rats; Succinates; Tritium; Water | 1974 |
Inhibition of hepatic mixed function oxidase activity by propyl gallate.
Topics: Aging; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Benzphetamine; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Diet; Gallic Acid; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
A direct test for mono-oxygenase activity of intact small intestine using surface reflectance fluorimetry.
Topics: Animals; Coumarins; Dealkylation; Fluorometry; Glucose; Hypotonic Solutions; In Vitro Techniques; Intestine, Small; Kinetics; Male; Mice; Mice, Inbred C57BL; NADP; Oxygenases; Phenobarbital; Time Factors | 1974 |
Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Cytochrome c Group; Cytochrome Reductases; Cytosol; Dialysis; Electron Transport; Female; Hydrazines; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Nitrofurans; Nitrofurantoin; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Thiazoles; Xanthine Oxidase | 1974 |
Drugs, alcohol and sex hormones: a molecular perspective of the receptivity of cytochrome P-450.
Topics: Adrenal Glands; Animals; Barbiturates; Binding, Competitive; Cattle; Cytochrome P-450 Enzyme System; Electron Transport; Estradiol; Ethanol; Gonadal Steroid Hormones; Hexobarbital; Microsomes; Microsomes, Liver; Mitochondria; Morphine Derivatives; NAD; NADP; Oxidation-Reduction; Phenobarbital; Testosterone | 1973 |
7 Alpha-hydroxylation of cholesterol by reconstituted systems from rat liver microsomes.
Topics: Animals; Cholesterol; Cholestyramine Resin; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Hydroxylation; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Phosphatidylcholines; Rats | 1974 |
Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Hydroxylation; Kinetics; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Structure-Activity Relationship | 1974 |
Alteration of norepinephrine metabolism by barbiturates.
Topics: Animals; Barbiturates; Brain Stem; Liver; NAD; NADP; Norepinephrine; Pentobarbital; Phenobarbital; Rats; Semicarbazides | 1974 |
Phosphines as ligands to microsomal cytochrome P-450.
Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Dithionite; Electron Spin Resonance Spectroscopy; Kinetics; Ligands; Microsomes, Liver; Microwaves; NADP; Oxidation-Reduction; Phenobarbital; Phosphines; Protein Binding; Protein Conformation; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet | 1974 |
The effect of ethchlorvynol on the drug-metabolizing enzymes of rats and dogs.
Topics: Aminopyrine; Animals; Dicumarol; Dogs; Ethchlorvynol; Glutethimide; Hypnotics and Sedatives; Liver; Microsomes; NADP; Phenobarbital; Rats | 1967 |
Characterization of microsomal membranes by negative staining technique.
Topics: Acid Phosphatase; Animals; Cattle; Cytochromes; Endoplasmic Reticulum; Golgi Apparatus; Histological Techniques; Hydrogen-Ion Concentration; Liver; Lysosomes; Male; Membranes; Microscopy, Electron; Microsomes; Microsomes, Liver; Mitochondria; Mitochondria, Liver; NADP; Phenobarbital; Phosphotungstic Acid; Proteins; Rats; Ribosomes; RNA; Staining and Labeling | 1968 |
Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study.
Topics: Aminopyrine; Animals; Carbon Monoxide; Codeine; Dactinomycin; Endoplasmic Reticulum; In Vitro Techniques; Liver; Microscopy, Electron; Microsomes; NADP; Nitrosamines; Oxidoreductases; Phenobarbital; Pigments, Biological; Puromycin; Rats; Thyroidectomy; Triiodothyronine | 1965 |
Metabolism of trichloroethylene in liver microsomes. I. Characteristics of the reaction.
Topics: Animals; Chloral Hydrate; Chloromercuribenzoates; Cyanides; Dogs; Enzymes; Ethylmaleimide; Flavin Mononucleotide; Freeze Drying; In Vitro Techniques; Iodoacetates; Ions; Liver; Methylene Blue; Microsomes; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Trichloroethylene; Vitamin K | 1965 |
Studies on the demethylation of puromycin and related compounds by liver microsomal enzymes.
Topics: Animals; In Vitro Techniques; Liver; Microsomes; NADP; Nucleosides; Phenobarbital; Proadifen; Purines; Puromycin; Rats | 1966 |
Substrate interaction with hydroxylase system in liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Cyanides; Cytochromes; Guinea Pigs; In Vitro Techniques; Liver; Microsomes; Mixed Function Oxygenases; NADP; Phenacetin; Phenobarbital; Rabbits; Rats; Spectrophotometry | 1966 |
The turnover of microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase in the livers of mice treated with phenobarbital.
Topics: Animals; Cytochromes; Electrophoresis; In Vitro Techniques; Leucine; Liver; Mice; Microsomes; NADP; Oxidoreductases; Phenobarbital | 1966 |
Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chromatography, Thin Layer; Enzymes; Female; Guinea Pigs; In Vitro Techniques; Liver; Male; Mice; Microsomes; NADP; Nitrogen; Nitrophenols; Oxygen; Parathion; Phenobarbital; Phosphates; Phosphorus Isotopes; Rats | 1967 |
Comparison of drug-metabolizing and olefin-forming systems in rat liver.
Topics: Animals; Body Weight; Dietary Fats; Fatty Acids; In Vitro Techniques; Liver; Male; Microsomes; NADP; Organ Size; Phenobarbital; Rats | 1967 |
Interaction between liver microsomes and compounds capable of undergoing enzymic hydroxylation.
Topics: Aniline Compounds; Animals; Carbon Isotopes; Cytochromes; In Vitro Techniques; Liver; Microsomes; NADP; Phenobarbital; Rats | 1967 |
Magnetic and spectrophotometric properties of the microsomal carbon monoxide binding pigment.
Topics: Animals; Carbon Monoxide; Chlordan; Coloring Agents; Cytochromes; DDT; Diphenhydramine; Electron Spin Resonance Spectroscopy; Fasting; Ferrocyanides; Hydrogen-Ion Concentration; Liver; Microsomes; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Pigments, Biological; Rabbits; Rats; Spectrophotometry | 1967 |
Studies on the mechanism of action of mammalian hepatic azoreductase. II. The effects of phenobarbital and 3-methylcholanthrene on carbon monoxide sensitive and insensitive azoreductase activities.
Topics: Animals; Azo Compounds; Carbon Monoxide; Cytochromes; Female; Lipase; Liver; Methylcholanthrene; Microsomes; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats; Tetrazolium Salts | 1967 |
Effect of phenobarbital treatment on the activities of NADPH-dependent enzymes of liver microsomes in fasting or sucrose-fed rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzoates; Carbon Isotopes; Female; Liver; Male; Microsomes; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Phenylalanine; Rats; Starvation; Sucrose | 1967 |
Determination of initial rates of cortisol 2-alpha- and 6-beta-hydroxylation by hepatic microsomal preparations in guinea pigs: effect of phenobarbital in two genetic types.
Topics: Animals; Carbon Isotopes; Guinea Pigs; Hydrocortisone; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microsomes; Mixed Function Oxygenases; Molecular Biology; NADP; Phenobarbital; Stimulation, Chemical | 1968 |
Acute effects of 3'-methyl-4-dimethylaminoazobenzene intoxication on rat liver. Structural and functional changes in the endoplasmic reticulum and NADPH-related electron transport.
Topics: Aniline Compounds; Animals; Cytochromes; Electron Transport; Endoplasmic Reticulum; Injections, Intraperitoneal; Lipid Metabolism; Liver; Male; Microscopy, Electron; NADP; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1968 |
Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit.
Topics: Aminopyrine; Animals; Antipyrine; Chromatography, Thin Layer; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microsomes; NADP; Oxygen; Phenobarbital; Rabbits; Rats | 1968 |
The electron transport mechanism associated with 12 alpha-hydroxylation of C27 steroids.
Topics: Animals; Cholestanes; Chromatography, Thin Layer; Electron Transport; Liver; Microsomes; NADP; Oxidation-Reduction; Phenobarbital; Pigments, Biological; Rats | 1968 |
Hepatic microsomes and drug oxidation.
Topics: Animals; Cytochromes; Endoplasmic Reticulum; Insecticides; Liver; Maryland; Methylcholanthrene; Molecular Biology; NADP; National Library of Medicine (U.S.); Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; RNA, Messenger; Smoking; Steroids; Testosterone; United States | 1968 |
On the fatty acid and hydrocarbon hydroxylation in rat liver microsomes.
Topics: Alkanes; Aminopyrine; Animals; Carbon Monoxide; Cytochromes; Depression, Chemical; Fatty Acids; Fluorometry; Liver; Male; Microsomes; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Pigments, Biological; Rats; Stimulation, Chemical; Testosterone | 1968 |
Oxidation of indene in liver microsomes.
Topics: Animals; Chromatography, Gas; Chromatography, Thin Layer; Ethers, Cyclic; Glycols; In Vitro Techniques; Indenes; Liver; Male; Microsomes; NADP; Oxidative Phosphorylation; Phenobarbital; Rabbits; Rats | 1968 |
[Hydroxylase activity and hemoprotein content of microsomes from rabbit liver].
Topics: Aniline Compounds; Animals; Cyanides; Cytochromes; Female; Liver; Male; Microsomes; Mixed Function Oxygenases; NAD; NADP; Phenobarbital; Rabbits | 1968 |
[Hydroxylamino- and nitrosobiphenyl: biological oxidation products of 4-aminobiphenyl and intermediates of 4-nitrobiphenyl reduction].
Topics: Animals; Biphenyl Compounds; Cats; Chromatography, Thin Layer; Colorimetry; Flavin Mononucleotide; Fluorenes; Hemoglobins; Hydroxylamines; Methemoglobin; NADP; Nitroso Compounds; Oxygen; Phenobarbital; Proteins; Rats; Spectrum Analysis; Ultraviolet Rays | 1967 |
[Differential induction of microsomal N- and p-hydroxylation of aniline and N-ethylamiline in rabbits].
Topics: Anesthetics, Local; Aniline Compounds; Animals; Chloramphenicol; Dactinomycin; Enzyme Induction; Ethionine; Female; Hydroxylamines; Liver; Male; Microsomes; Mixed Function Oxygenases; NADP; Phenobarbital; Phenols; Rabbits | 1967 |
Heterogeneity of rough-surfaced liver microsomal membranes of adult, phenobarbital-treated, and newborn rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Centrifugation, Density Gradient; Electron Transport Complex IV; Fasting; Glucose-6-Phosphatase; Glycerol; Leucine; Liver; Membranes; Microscopy, Electron; Microsomes; NAD; NADP; Osmosis; Phenobarbital; Proteins; Rats; Tritium | 1968 |
Properties of a submicrosomal particle containing P-450 and flavoprotein.
Topics: Adrenal Glands; Animals; Carbon Monoxide; Cattle; Cyanides; Cytochromes; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Liver; Methods; Microsomes; NADP; Nitric Oxide; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Pigments, Biological; Proteins; Rabbits; Riboflavin; Spectrophotometry | 1968 |
Drug metabolism in tumor-bearing rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of tumor-bearing rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Barbiturates; Body Weight; Carcinoma 256, Walker; Carisoprodol; Cyclophosphamide; Electron Transport; Electron Transport Complex IV; Female; Liver; Male; Microsomes; Mixed Function Oxygenases; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats | 1968 |
[Water-soluble metabolites of estradiol-17-beta. 3. Separation and identification of 1- and 4-glutathione thioethers of 2,3-dihydroxy-estratrienes].
Topics: Animals; Biotransformation; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Electrophoresis; Estradiol; Estranes; Female; Glutathione; Liver; NADP; Phenobarbital; Rats; Solubility; Stereoisomerism; Stimulation, Chemical; Sulfides | 1969 |
Alteration in the magnitude of induction of tyrosine transaminase by glucocorticoids. II. Effects of phenobarbital, o,p' DDD and diethylaminoethyl diphenylpropylacetate (SKF 525A) on metabolism of triamcinolone acetonide.
Topics: Adrenal Glands; Adrenalectomy; Animals; Chromatography, Thin Layer; Depression, Chemical; Dichlorodiphenyldichloroethane; Drug Synergism; Enzyme Induction; Kinetics; Liver; Male; NADP; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Time Factors; Triamcinolone Acetonide; Tritium; Tyrosine Transaminase | 1969 |
On the hydroxylation of cyclohexane in rat liver microsomes.
Topics: Alcohols; Animals; Benzopyrenes; Chromatography, Gas; Cyclohexanes; Depression, Chemical; Kinetics; Liver; Microsomes; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
Investigations on pantothenic acid and its related compounds. XX. Biochemical studies. 11. Enzymatic conversion of 2'-ketopantothenate to D-pantothenate in rat.
Topics: Animals; Cell Nucleus; Glucose-6-Phosphatase; In Vitro Techniques; Liver; Male; Microsomes; Mitochondria, Liver; NAD; NADP; Oxidoreductases; Oxygen; Pantothenic Acid; Phenobarbital; Rats; Stereoisomerism; Succinate Dehydrogenase | 1969 |
Oxidative enzyme components of avian liver microsomes. Changes during embryonic development and the effects of phenobarbital administration.
Topics: Animals; Chick Embryo; Chickens; Cyanides; Cytochromes; Electron Transport; Liver; Microsomes; NAD; NADP; Niacinamide; Oxidoreductases; Phenobarbital; Spectrophotometry; Spectrum Analysis | 1969 |
Some properties of the microsomal system metabolizing DDT in Triatoma infestans.
Topics: Animals; Chloromercuribenzoates; DDT; Depression, Chemical; Enzyme Induction; Hydrogen-Ion Concentration; Insecta; Kinetics; Magnesium; Microsomes; NAD; NADP; Niacinamide; Phenobarbital; Stimulation, Chemical; Sulfhydryl Compounds; Temperature; Time Factors; Triatominae | 1969 |
Metabolism and cytochrome P-450 binding spectra of (+)- and (-)-hexobarbital in rat liver microsomes.
Topics: Animals; Cytochromes; Hexobarbital; Kinetics; Liver; Male; Microsomes; NADP; Phenobarbital; Rats; Spectrophotometry; Stereoisomerism | 1969 |
Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Cytochromes; Depression, Chemical; Drug Stability; Electron Spin Resonance Spectroscopy; Fatty Acids; Guinea Pigs; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Lipid Metabolism; Liver; Male; Microsomes; NAD; NADP; Oxidoreductases; Phenobarbital; Rabbits; Rats; Solubility; Spectrophotometry; Stimulation, Chemical | 1969 |
Microsomal hydroxylation of decane.
Topics: Alcohols; Alkanes; Aniline Compounds; Animals; Carbon Isotopes; Carbon Monoxide; Cattle; Chick Embryo; Columbidae; Cyanides; Fatty Acids; Glycols; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Lung; Male; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Phenobarbital; Proadifen; Rabbits; Rats | 1969 |
The inhibitory effect of aureomycin (chlortetracycline) pretreatment on some rat liver microsomal enzyme activities.
Topics: Albumins; Aminopyrine; Animals; Body Weight; Chlortetracycline; Cytochromes; Depression, Chemical; Hexobarbital; Injections, Intraperitoneal; Liver; Magnesium; Male; Microsomes; NADP; Organ Size; Phenobarbital; Proteins; Rats; Sleep | 1969 |
Biosynthesis of microsomal nicotinamide-adenine dinucleotide phosphate-cytochrome c reductase by membrane-bound and free polysomes from rat liver.
Topics: Amino Acids; Amylases; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Cytochromes; Depression, Chemical; Detergents; Endoplasmic Reticulum; Liver; Male; Membranes; Methods; Microsomes; NADP; Oxidoreductases; Phenobarbital; Proteins; Puromycin; Rats; Ribosomes; Stimulation, Chemical; Trypsin | 1969 |
[Influence of diethylnitrosamine, carbon tetrachloride, butter yellow and cyclophosphamide on amino acid incorporation into fractions of liver homogenates after metabolic activation in vitro. Possibilities for the detection of hepatotoxic effects].
Topics: Amino Acids; Aniline Compounds; Animals; Carbon Isotopes; Carbon Tetrachloride; Cyclophosphamide; Leucine; Liver; Male; Microsomes; Models, Biological; NADP; Nitrosamines; p-Dimethylaminoazobenzene; Phenobarbital; Protein Biosynthesis; Rats | 1969 |
The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene.
Topics: Acyltransferases; Amino Acids; Animals; Azo Compounds; Benzopyrenes; Carbon Isotopes; Cytochromes; Depression, Chemical; Enzyme Induction; Glycine; Heme; Levulinic Acids; Liver; Male; Microsomes; NADP; Oxidoreductases; Phenobarbital; Rats; Stimulation, Chemical; Time Factors; Transferases; Triazoles | 1969 |
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.
Topics: Aminopyrine; Animals; Appetite Depressants; Benzphetamine; Cytochromes; Depression, Chemical; Ethers; Fatty Acids; Formaldehyde; Hexobarbital; Lipid Metabolism; Liver; Microsomes; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenethylamines; Phenobarbital; Propylamines; Rabbits; Spectrophotometry | 1969 |
Studies on the mechanism of nitro reduction by rat liver.
Topics: Aminobenzoates; Animals; Female; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Oxidoreductases; Oxygen; Phenobarbital; Rats | 1969 |
Significance of mixed oxygenases and nitroreductase in drug metabolism.
Topics: Animals; Anthelmintics; Carbon Monoxide; Carbon Tetrachloride; Chemical Phenomena; Chemistry; Cytochromes; Haplorhini; Imidazoles; Microsomes, Liver; NADP; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygenases; Pharmaceutical Preparations; Phenobarbital | 1969 |
Influence of phenobarbital pretreatment on the in vitro ring A reduction of delta4-3-oxo-steroids in rat liver microsomes.
Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Isotopes; Carbon Monoxide; Chloromercuribenzoates; Chromatography, Thin Layer; Cyanides; Cytochromes; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
[Separation of metabolically distinct cell fractions from isolated rat hepatocytes].
Topics: Acetates; Animals; Autoradiography; Carbon Isotopes; Centrifugation, Density Gradient; Cholesterol; Cytochromes; Glucose-6-Phosphatase; In Vitro Techniques; Liver; Methods; Microscopy, Electron; NADP; Oxidoreductases; Phenobarbital; Rats; RNA | 1969 |
Mixed function oxidation in perfused rat liver. The effect of aminopyrine on oxygen uptake.
Topics: Aminopyrine; Animals; Antimycin A; Cyanides; Depression, Chemical; Drug Synergism; Fasting; Fluorometry; Hemoglobins; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Models, Biological; NADP; Oxidoreductases; Oxygen Consumption; Perfusion; Phenobarbital; Rats; Stimulation, Chemical; Time Factors | 1969 |
[Control of mixed function oxygenation in the perfused liver].
Topics: Animals; Antimycin A; In Vitro Techniques; Ligases; Liver; Malate Dehydrogenase; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Rats | 1969 |
Histochemical demonstration of enzymes related to NADPH-dependent hydroxylating systems in rat liver after phenobarbital treatment.
Topics: Aniline Compounds; Animals; Cytochromes; Electron Transport; Esterases; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Histocytochemistry; Isocitrate Dehydrogenase; Liver; Male; Microsomes, Liver; NADP; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital.
Topics: Animals; Azo Compounds; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Hydro-Lyases; Iron Isotopes; Levulinic Acids; Male; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Time Factors; Triazoles | 1969 |
Effects of metyrapone on liver microsomal drug oxidations.
Topics: Acetanilides; Aminopyrine; Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Morphine; NADP; Phenobarbital; Rats; Sleep; Stimulation, Chemical; Trichloroethylene; Tyramine | 1969 |
Hepatic drug-metabolizing enzyme activity in rats pretreated with (-)-emetine or (plus or minus)-2,3-dehydroemetine.
Topics: Aminopyrine; Animals; Depression, Chemical; Drug Synergism; Emetine; Female; Glucosephosphate Dehydrogenase; Hexobarbital; Liver; Microsomes, Liver; NADP; Phenobarbital; Rats; Sulfonamides | 1970 |
Interaction of gluconeogenesis and mixed function oxidation.
Topics: Acetone; Aminopyrine; Animals; Gluconeogenesis; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; In Vitro Techniques; Lactates; Liver; Microsomes, Liver; NADP; Perfusion; Phenobarbital; Rats; Trioses | 1970 |
Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Aldehydes; Animals; Brain; Carbon Isotopes; Cattle; Chlorpromazine; Hydrogen-Ion Concentration; Hypothalamus; Kinetics; NADP; Phenobarbital; Pons; Pyrazoles | 1970 |
A study of some possible mechanisms by which magnesium activates hepatic microsomal drug metabolism in vitro.
Topics: Aniline Compounds; Animals; Benzphetamine; Chlortetracycline; Cytochromes; Electron Transport; In Vitro Techniques; Magnesium; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats | 1970 |
Oxygen interaction with reduced cytochrome P-450.
Topics: Adrenal Glands; Animals; Catalase; Citrates; Cytochromes; Hydrogen Peroxide; Isocitrate Dehydrogenase; Microsomes, Liver; Mitochondria; NADP; Niacinamide; Oxygen; Phenobarbital; Rabbits; Spectrum Analysis; Succinates | 1968 |
Hydroxylation of aliphatic compounds by liver microsomes. I. The distribution pattern of isomeric alcohols.
Topics: Alcohols; Alkanes; Animals; Chromatography, Gas; Cyclohexanes; Guinea Pigs; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rabbits; Rats | 1970 |
Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.
Topics: Animals; Benzoates; Cyclophosphamide; Cytochromes; Female; Glucose-6-Phosphatase; Hexobarbital; Hydrocortisone; Male; Microsomes, Liver; NADP; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Sex Factors; Testosterone | 1970 |
Interaction of mixed function oxidase with its substrates and associated redox transitions of cytochrome P-450 and pyridine nucleotides in perfused rat liver.
Topics: Animals; Cytochromes; Endoplasmic Reticulum; Fluorescence; Hexobarbital; Lactates; Liver; Male; Metyrapone; Microsomes, Liver; NAD; NADP; Oxidoreductases; Oxygen Consumption; Perfusion; Phenobarbital; Pyruvates; Rats; Spectrophotometry | 1970 |
Studies on the induction of nitroreductase activity by DDT and phenobarbital.
Topics: Aminobenzoates; Animals; Benzoates; Cyanides; DDT; Enzyme Induction; Liver; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats; Sodium; Venoms | 1970 |
6 Beta-hydroxylation of triamcinolone acetonide by a hepatic enzyme system. The effect of phenobarbital and 1-benzyl-2-thio-5,6-dihydrouracil.
Topics: Animals; Chromatography, Thin Layer; Enzyme Induction; Liver; Male; Microsomes, Liver; NADP; Oxygenases; Phenobarbital; Pregnanes; Rats; Thiouracil; Triamcinolone Acetonide | 1970 |
Oxidation of 5 beta-cholestane-3alpha, 7alpha, 12alpha-triol by rat liver microsomes.
Topics: Alcohols; Animals; Bile; Biliary Fistula; Carbon Isotopes; Carbon Monoxide; Cholestanes; Chromatography, Gas; Chromatography, Thin Layer; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Tritium | 1970 |
[Hydroxylation of progesterone by rabbit liver microsomes. Changes in metabolite pattern after phenobarbital treatment of the animals].
Topics: Animals; Biotransformation; Carbon Monoxide; Chromatography, Gel; Chromatography, Paper; Cytochromes; Enzyme Induction; Female; Freezing; Hydrogen-Ion Concentration; Hydroxyprogesterones; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Progesterone; Rabbits | 1970 |
Omega- and (omega - 1)-oxidation of fatty acids by rat liver microsomes.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, Gas; Depression, Chemical; Dicarboxylic Acids; Fatty Acids; Male; Microsomes, Liver; NAD; NADP; Oxidoreductases; Palmitic Acids; Phenobarbital; Rats; Spectrum Analysis; Stearic Acids; Stimulation, Chemical; Tritium | 1970 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Topics: Animals; Autoradiography; Benzene Derivatives; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Drug Synergism; Glutathione; Hydrocarbons, Halogenated; Liver; Liver Diseases; Male; Microsomes, Liver; NADP; Naphthalenes; Necrosis; Phenobarbital; Rats | 1971 |
Effect of cholestyramine on the terminal reactions of sterol biosynthesis.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholestyramine Resin; Cytochromes; Electron Transport; Kinetics; Male; Mevalonic Acid; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Rats; Sterols | 1970 |
The effects of adjuvant-induced arthritis on the liver metabolism of drugs in rats.
Topics: Acetaminophen; Adjuvants, Immunologic; Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis; Biological Transport, Active; Blood Proteins; Cholesterol; Cytochromes; Electrons; Glucose-6-Phosphatase; Glucuronates; Histocytochemistry; In Vitro Techniques; Liver Glycogen; Lymph Nodes; Male; Microsomes, Liver; Mycobacterium tuberculosis; NADP; Oxidoreductases; Phenobarbital; Rats; RNA; Serum Albumin; Succinate Dehydrogenase | 1970 |
The effect of diet and phenobarbitone on quinine metabolism in the rat and in man.
Topics: Animals; Diet; Humans; In Vitro Techniques; Male; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Proteins; Quinine; Rabbits; Rats; Species Specificity; Time Factors | 1970 |
The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Calcium; Chlorides; Cobalt; Copper; Cytochromes; Edetic Acid; Hexobarbital; In Vitro Techniques; Iron; Magnesium; Male; Manganese; Microsomes, Liver; NADP; Nitrophenols; Phenobarbital; Potassium; Rats; Strontium; Sulfates; Zinc; Zoxazolamine | 1970 |
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.
Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature | 1970 |
Different turnover behavior of phenobarbital-induced and normal NADPH-cytochrome c reductases in rat liver microsomes.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cytochromes; Guanidines; Leucine; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Phospholipids; Proteins; Rats; RNA | 1971 |
Uncoupling of monooxygenation and electron transport by fluorocarbons in liver microsomes.
Topics: Animals; Electron Transport; Fluorine; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Paraffin; Phenobarbital; Rats | 1971 |
[Reductive degradation of metyrapone in rat liver].
Topics: Animals; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats | 1970 |
Genetic aspects of increase in rat liver aldehyde dehydrogenase induced by phenobarbital.
Topics: Animals; Enzyme Induction; Female; Liver; Male; Microsomes, Liver; Mitochondria; Molecular Biology; NADP; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1971 |
On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.
Topics: Animals; Carbon Monoxide; Chlorides; Cytochromes; Dealkylation; Electron Transport; Fasting; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Magnesium; Male; Mercury; Microsomes, Liver; Morphinans; NAD; NADP; Organomercury Compounds; Osmolar Concentration; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Phenobarbital; Phosphates; Polarography; Potassium Chloride; Rats; Spectrophotometry; Time Factors; Tromethamine; Ultracentrifugation | 1971 |
Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions.
Topics: Aldehydes; Anaerobiosis; Animals; Chlorides; Colorimetry; Cytochromes; Electron Transport; Formaldehyde; Isocitrate Dehydrogenase; Kinetics; Lipid Metabolism; Magnesium; Male; Malonates; Microsomes, Liver; Models, Biological; Morphinans; Myocardium; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Spectrophotometry; Tromethamine | 1971 |
Fatty acid inducible cy tochrome P-454 of rat kidney cortex microsomes.
Topics: Aminopyrine; Animals; Carbon Monoxide; Cytochromes; Dietary Fats; Electron Transport; Fatty Acids, Nonesterified; Kidney; Male; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry; Sulfites; Testosterone | 1970 |
Subfractionation of smooth microsomes from rat liver.
Topics: Adenosine Triphosphatases; Animals; Cell Fractionation; Cell Membrane; Centrifugation, Density Gradient; Centrifugation, Zonal; Cholesterol; Electron Transport; Electron Transport Complex IV; Filtration; Glucose-6-Phosphatase; Glycerol; Liver; Male; Microsomes, Liver; Monoamine Oxidase; NAD; NADP; Phenobarbital; Phospholipids; Phosphoric Monoester Hydrolases; Proteins; Rats; RNA; Time Factors; Tritium | 1970 |
Oxidation of cholesterol, 3 -hydroxy-5-pregnen-20-one and 3 -hydroxy-5-androsten-17-one by rat liver microsomes.
Topics: Animals; Biliary Fistula; Carbon Monoxide; Cholesterol; Chromatography, Gas; Dehydroepiandrosterone; In Vitro Techniques; Linoleic Acids; Lipid Metabolism; Male; Mass Spectrometry; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnanes; Rats | 1971 |
A comparison of the effects of halothane and CCl 4 on the hepatic drug metabolizing system.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochromes; Dealkylation; Halothane; Liver; Male; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats | 1971 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Paper; Ethers, Cyclic; Glutathione; Hydrocarbons, Halogenated; Iodine; Liver; Male; Mice; Microsomes, Liver; Models, Biological; NADP; Necrosis; Phenobarbital; Rats; Sheep; Sulfur Isotopes | 1971 |
The role of microsomes in the hepatic metabolism of ethanol.
Topics: Acetates; Adenine Nucleotides; Aerobiosis; Amino Alcohols; Anaerobiosis; Animals; Azides; Bile Acids and Salts; Carbon Monoxide; Catalase; Cell Fractionation; Chlorides; Chloromercuribenzoates; Copper; Cyanides; Diet; Dimethyl Sulfoxide; Edetic Acid; Ethanol; Female; Hot Temperature; Hydrogen Peroxide; Iron; Liver; Mercury; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Pyrazoles; Rats; Sulfides; Triazoles | 1971 |
Enzymatic reduction of niridazole by rat liver microsomes.
Topics: Aerobiosis; Animals; Anthelmintics; Carbon Monoxide; Chemical Precipitation; Chromatography, Gas; Cytochromes; Guinea Pigs; Hydroxylamines; Imidazoles; Ketones; Lipase; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Nitro Compounds; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygen; Pancreatic Juice; Phenobarbital; Quaternary Ammonium Compounds; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfates; Tetrazolium Salts; Thiazoles | 1971 |
Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes.
Topics: Acetamides; Allyl Compounds; Animals; Bacillus subtilis; Carbon Monoxide; Cell Fractionation; Chick Embryo; Cytochromes; Depression, Chemical; Detergents; Etiocholanolone; Female; Flavins; Heme; Ketosteroids; Liver; Methods; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Nitrogen; Oxidoreductases; Peptide Hydrolases; Phenobarbital; Pregnanes; Rats; Solubility; Spectrophotometry; Stimulation, Chemical | 1971 |
Effect of caffeine on hepatic microsomal cytochrome P-450.
Topics: Acetanilides; Adrenalectomy; Animals; Anisoles; Caffeine; Cytochromes; Enzyme Induction; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitriles; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry; Sulfites; Time Factors | 1970 |
Further studies on the submicrosomal distribution of drug-metabolizing components in liver. Localization in fractions of smooth microsomes.
Topics: Aniline Compounds; Animals; Centrifugation, Density Gradient; Cytochromes; Guinea Pigs; Histocytochemistry; Male; Membranes; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Phospholipids; Proteins | 1971 |
The distinct nature and function of NADPH-cytochrome c reductase and the NADPH-dependent mixed-function amine oxidase of porcine liver microsomes.
Topics: Aminopyrine; Ammonium Sulfate; Aniline Compounds; Animals; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cross Reactions; Cytochromes; Electrophoresis; Electrophoresis, Disc; Female; Flavin-Adenine Dinucleotide; Flavoproteins; Immune Sera; Immunodiffusion; Lipase; Lipoprotein Lipase; Methylamines; Microsomes, Liver; Mixed Function Oxygenases; Models, Biological; Molecular Weight; Monoamine Oxidase; NADP; Oxidoreductases; Pancreas; Phenobarbital; Swine; Ultracentrifugation | 1971 |
Inhibition of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from bovine brain by barbiturates.
Topics: Alcohol Oxidoreductases; Aldehydes; Amobarbital; Animals; Barbiturates; Brain; Cattle; Dialysis; Horses; Hydrogen-Ion Concentration; In Vitro Techniques; Ions; Kinetics; Liver; NADP; Pentobarbital; Phenobarbital; Pyrazoles; Sodium; Sulfites | 1971 |
Formation of a factor lethal for S. typhimurium TA1530 and TA1531 on incubation of aflatoxin B 1 with rat liver microsomes.
Topics: Aflatoxins; Aniline Compounds; Animals; Carbon Monoxide; Caseins; Chromatography, Thin Layer; Depression, Chemical; Diet; Male; Microsomes, Liver; NADP; Nitrogen; Oxygen Consumption; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1971 |
Induction by phenobarbital of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) cytochrome c reductase in regenerating rat liver.
Topics: Animals; Arginine; Carbon Isotopes; Cytochromes; Enzyme Induction; Hepatectomy; Leucine; Liver; Liver Regeneration; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Protein Biosynthesis; Rats; Stress, Physiological; Tritium | 1971 |
A new spectral species associated with cytochrome P-450 in liver microsomes.
Topics: Animals; Cytochromes; In Vitro Techniques; Microsomes, Liver; NADP; Phenobarbital; Rats; Spectrophotometry | 1971 |
The state of NADPH-NADP + during mixed-function oxidation of hexobarbital in hemoglobin-free perfused rat liver.
Topics: Animals; Fluorometry; Hemoglobins; Hexobarbital; Liver; Mitochondria, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Perfusion; Phenobarbital; Rats | 1971 |
Conversion of agroclavine by mammalian cytochrome P-450.
Topics: Adrenal Glands; Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chromatography, Thin Layer; Cytochromes; Ergot Alkaloids; Guinea Pigs; Isotope Labeling; Male; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity; Spectrophotometry; Tryptophan | 1971 |
The interaction of a fluorescent probe with rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Oxidoreductases; Phenobarbital; Rats; Sulfites; Sulfonic Acids; Warfarin | 1970 |
Chemical and enzymatic composition of microsomal subfractions from rat liver after treatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cholesterol; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Proteins; Rats; RNA; Spectrum Analysis; Tritium | 1970 |
Phenobarbital-induced changes in NADPH-cytochrome c reductase and smooth endoplasmic reticulum in human liver.
Topics: Biopsy; Biotransformation; Child, Preschool; Cholestasis; Electron Transport Complex IV; Endoplasmic Reticulum; Humans; Infant; Infant, Newborn; Liver; Microscopy, Electron; NADP; Phenobarbital; Stimulation, Chemical | 1972 |
[Extraction of cytochrome P450 after incubation with CCl 4 in an NADPH-regenerating system and partial transformation into cytochrome P420].
Topics: Animals; Carbon Tetrachloride; Cytochromes; Drug Interactions; Male; Microsomes; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1971 |
The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.
Topics: Alkaloids; Animals; Calcium; Carbon Monoxide; DDT; Diet; Kinetics; Lung; Magnesium; Manganese; Microsomes; Microsomes, Liver; Models, Biological; NADP; Niacinamide; Oxides; Oxygen; Phenobarbital; Proadifen; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1971 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
A comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes.
Topics: Aminopyrine; Animals; Benzopyrenes; Carbon Monoxide; Cytochromes; Enzyme Activation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry | 1969 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.
Topics: Animals; Benzopyrenes; Carbon Isotopes; Catalysis; Cytochromes; Dealkylation; Enzyme Induction; Hydroxylation; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Piperazines; Rats; Testosterone | 1972 |
Effect of spironolactone and ethylestrenol on benzo(a)pyrene hydroxylase (EC 1.14.1.1) and other chemical constituents of hepatic microsomes.
Topics: Animals; Benzopyrenes; Cytochromes; Ethylestrenol; Female; Fluorometry; Indophenol; Liver; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Phenols; Phospholipids; Proteins; Rats; Rats, Inbred Strains; Spectrophotometry; Spironolactone; Subcellular Fractions | 1971 |
Selective increases in type I hydrogen from reduced nicotinamide-adenine dinucleotide phosphate in liver from phenobarbitone-treated rats.
Topics: Animals; Glucosephosphate Dehydrogenase; Hydrogen; Liver; Male; NAD; NADP; Oxidation-Reduction; Phenobarbital; Phosphogluconate Dehydrogenase; Rats | 1971 |
The effect of phenobarbitone on the production of type I hydrogen from reduced nicotinamide-adenine phosphate in different regions of the liver lobule.
Topics: Animals; Benzene Derivatives; Densitometry; Hydrogen; Liver; NADP; Naphthalenes; Necrosis; Phenobarbital; Phosphogluconate Dehydrogenase; Rats | 1971 |
Hepatic microsomal lipoperoxidation and inhalation anesthetics: a biochemical and morphologic study in the rat.
Topics: Animals; Chloroform; Ethers; Ethyl Ethers; Female; Halothane; In Vitro Techniques; Lipid Metabolism; Liver; Male; Microsomes, Liver; NADP; Phenobarbital; Rats | 1972 |
Cytochrome P-450 as a microsomal peroxidase in steroid hydroxylations.
Topics: Animals; Cholesterol; Cytochromes; Estrone; Hydrocortisone; Linoleic Acids; Microsomes; Microsomes, Liver; NAD; NADP; Peroxidases; Phenobarbital; Pregnanes; Progesterone; Rats; Steroids; Testosterone | 1971 |
Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase in drug oxidation.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Dealkylation; Immune Sera; Immunodiffusion; Immunoglobulins; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Phenobarbital; Rabbits; Rats | 1971 |
Ascorbic acid and drug metabolism.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Ascorbic Acid; Ascorbic Acid Deficiency; Cytochromes; Fasting; Guinea Pigs; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitro Compounds; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Spectrophotometry; Subcellular Fractions | 1972 |
Evidence for superoxide generation by NADPH-cytochrome c reductase of rat liver microsomes.
Topics: Adrenochrome; Anaerobiosis; Animals; Epinephrine; Free Radicals; Hydrogen-Ion Concentration; In Vitro Techniques; Microsomes, Liver; NADP; Oxidoreductases; Oxygen; Peroxides; Phenobarbital; Rats | 1972 |
The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo.
Topics: Alcohol Oxidoreductases; Animals; Cytochromes; Diet; Ethanol; Kinetics; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Time Factors | 1972 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport; Endoplasmic Reticulum; Ethionine; Fatty Liver; Glucose-6-Phosphatase; Histocytochemistry; Liver; Macaca; Male; Microsomes, Liver; NADP; Necrosis; Oxidoreductases; Phenazines; Phenobarbital; Proadifen; Protein Deficiency; Rats; Rats, Inbred Strains | 1972 |
Enzymatic dechlorination. Dechlorination of chloroethanes and propanes in vitro.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlorine; Enzyme Induction; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Radioisotopes; Rats; Ultracentrifugation | 1971 |
[Enzymatic luminescence of the microsomes of hepatocytes].
Topics: Animals; Carbon Monoxide; Cytochromes; Electron Transport; Flavoproteins; Heterocyclic Compounds; Luminescent Measurements; Microsomes, Liver; NAD; NADP; Phenobarbital; Rats; Time Factors | 1972 |
Monooxygenase drug metabolizing activity in CaCl 2 -aggregated hepatic microsomes from rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Calcium Chloride; Carbon Monoxide; Chlorine; Dronabinol; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1972 |
The steroid 5 -reductase activity of rat liver and prostate.
Topics: Animals; Cell Nucleus; Dihydrotestosterone; Enzyme Induction; Female; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microsomes; Microsomes, Liver; Mitochondria; Mitochondria, Liver; NADP; Oxidoreductases; Phenobarbital; Prostate; Rats; Testosterone; Tritium | 1971 |
A comparison of mouse and rat liver enzymes and their response to treatment with various compounds.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Chlorpromazine; Clofibrate; Cytochromes; DDT; Germ-Free Life; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Griseofulvin; L-Lactate Dehydrogenase; Liver; Mice; NAD; NADP; Organ Size; Oxidoreductases; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Species Specificity | 1972 |
A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase.
Topics: Amobarbital; Animals; Barbiturates; Cytochromes; Hexobarbital; Hydrogen-Ion Concentration; Lipids; Male; Microsomes, Liver; NAD; NADP; Oxygenases; Pentobarbital; Phenobarbital; Rats; Secobarbital; Solubility; Spectrophotometry | 1972 |
Effect of phenobarbital on hepatic transport and excretion of 131 I-rose bengal in children with cholestasis.
Topics: Autoradiography; Bile; Biliary Tract Diseases; Bilirubin; Cholestasis; Feces; Female; Humans; Infant; Iodine Radioisotopes; Liver; Male; NADP; Oxidoreductases; Phenobarbital; Rose Bengal | 1972 |
A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro.
Topics: Animals; Female; Glucosephosphate Dehydrogenase; Glucosephosphates; Histamine H1 Antagonists; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Piperazines; Proteins; Rats; Rats, Inbred Strains; Time Factors; Tritium | 1972 |
Differential acute effects of phenobarbital and 3-methylcholanthrene pretreatment on CCl 4 -induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cytochrome c Group; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proteins; Rats; Time Factors | 1972 |
Liver microsomal metabolism of aflatoxin B 1 to a reactive derivative toxic to Salmonella typhimurium TA 1530.
Topics: Aflatoxins; Aniline Compounds; Animals; Carcinogens; Chromatography; Cricetinae; DNA; Female; Guinea Pigs; Humans; Hypophysectomy; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mycotoxins; NADP; Phenobarbital; Pituitary Gland; Rats; RNA; Salmonella typhimurium; Sex Factors; Species Specificity; Xanthenes | 1972 |
[Studies on the effects of azathioprine, choline orotate and phenobarbital on enzymes of the endoplasmatic reticulum and mitochondria of rat liver].
Topics: Acyltransferases; Animals; Aspartate Aminotransferases; Azathioprine; Choline; Cytochrome c Group; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Glucuronates; Liver; Male; Microsomes, Liver; Mitochondria, Liver; NADP; Orotic Acid; Oxidoreductases; Phenobarbital; Rats; Succinate Dehydrogenase | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.
Topics: Ammonium Sulfate; Animals; Benzopyrenes; Bile Acids and Salts; Catalysis; Chemical Precipitation; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Oxidoreductases; Phenobarbital; Phosphatidylcholines; Rats; Surface-Active Agents | 1972 |
Interactions of digitoxigenin and digoxigenin with cytochrome P-450.
Topics: Animals; Cardanolides; Cytochrome c Group; Drug Interactions; Hexobarbital; In Vitro Techniques; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Testosterone | 1972 |
Cytochrome P-450 in 7 -hydroxylation of taurodeoxycholic acid.
Topics: Animals; Bile Acids and Salts; Carbon Monoxide; Chromatography, Gas; Cytochrome P-450 Enzyme System; Deoxycholic Acid; Hydroxylation; Kinetics; Light; Male; Mathematics; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Taurocholic Acid | 1973 |
Influence of dietary iron levels on hepatic drug metabolism in vivo and in vitro in the rat.
Topics: Aminopyrine; Anemia, Hypochromic; Aniline Compounds; Animals; Body Weight; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Half-Life; Hematocrit; Hemoglobins; In Vitro Techniques; Iron; Liver; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proteins; Rats | 1972 |
Studies on the localization of reaction sites within the reduced nicotinamide-adenine dinucleotide phosphate-oxygenase system of rat liver microsomes for the N- and C-oxidation of dimethylaniline and for the peroxidation of unsaturated fatty acids.
Topics: Amobarbital; Aniline Compounds; Animals; Binding Sites; Catalase; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Detergents; Electron Transport; Enzyme Induction; Fatty Acids, Unsaturated; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygenases; Peroxides; Phenobarbital; Proteins; Rats; Spectrophotometry; Vitamin K | 1972 |
The monooxygenation of N-heptane by rat liver microsomes.
Topics: Aerobiosis; Alcohols; Alkanes; Animals; Carbon Monoxide; Chromatography, Gas; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Isomerism; Kinetics; Mass Spectrometry; Metyrapone; Microsomes, Liver; Myocardium; NADP; Oxidation-Reduction; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Swine; Vibration | 1972 |
Study of the increased glyceryl trinitrate metabolism after pretreatment with phenobarbital in rat liver.
Topics: Animals; Body Weight; Dactinomycin; Ethionine; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Reductase; In Vitro Techniques; Liver; Male; NADP; Nitrates; Nitroglycerin; Organ Size; Phenobarbital; Proteins; Rats; Spectrophotometry, Ultraviolet | 1972 |
A sensitive radiometric assay of aminopyrine N-demethylation.
Topics: Acetamides; Aminopyrine N-Demethylase; Animals; Carbon Isotopes; Chick Embryo; Colorimetry; Cytochrome P-450 Enzyme System; Dealkylation; Fetus; Formaldehyde; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kidney; Kinetics; Liver; Lung; Male; Methods; Methylcholanthrene; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Proteins; Rats | 1973 |
Studies on an unusual N-dealkylation reaction. II. Characteristics of the enzyme system and a proposed pathway for the reaction.
Topics: Anaerobiosis; Animals; Butanes; Carbon Tetrachloride; Cytoplasm; Decarboxylation; Histamine H1 Antagonists; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Oxides; Oxygen; Phenobarbital; Piperazines; Rats; Subcellular Fractions | 1973 |
In vitro activation of isophosphamide (NSC-109724), a new oxazaphosphorine, by rat liver microsomes.
Topics: Alkylating Agents; Alkylation; Aminopyrine; Aniline Compounds; Animals; Cyclic P-Oxides; Cyclophosphamide; Dealkylation; DNA; Enzyme Activation; Ethylamines; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; NADP; Oxazines; Oxidoreductases; Phenobarbital; Phosphoranes; Proadifen; Proteins; Rats; RNA | 1972 |
Stereochemical studies on the cytochrome P-450 and hydroxyl radical dependent pathways of 2-butanol oxidation by microsomes from chow-fed, phenobarbital-treated, and ethanol-treated rats.
Topics: Animals; Butanols; Cytochrome P-450 Enzyme System; Deferoxamine; Ethanol; Free Radicals; Hydroxides; Hydroxyl Radical; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1984 |
Carbon tetrachloride activation by highly purified liver mitochondrial preparations.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Cyanides; Glucose-6-Phosphatase; In Vitro Techniques; Male; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Reaction schemes for the degradation of cytochromes P-450 by allyl-isopropylacetamide and fluroxene.
Topics: Acetamides; Allylisopropylacetamide; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Ethers; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
1,1,1-Trichloropropene-2,3-oxide: an alternate mechanism for its inhibition of cytochrome P-450.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Ethers; Heme; Hydrocarbons, Chlorinated; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Trichloroepoxypropane | 1982 |
Effect of carbon disulfide on superoxide anion production by rat liver microsomes.
Topics: Aniline Compounds; Animals; Carbon Disulfide; Cytochrome c Group; Heme; Male; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Potassium Cyanide; Rats; Superoxides | 1981 |
Hydrogen peroxide-supported oxidation of benzo [a]pyrene by rat liver microsomal fractions.
Topics: Animals; Benzene Derivatives; Benzo(a)pyrene; Benzopyrenes; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Kinetics; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Rats | 1981 |
NADPH-dependent production of oxy radicals by purified components of the rat liver mixed function oxidase system. II. Role in microsomal oxidation of ethanol.
Topics: Animals; Cytochrome P-450 Enzyme System; Edetic Acid; Ethanol; Free Radicals; Hydroxides; Hydroxyl Radical; Iron; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Complete stoichiometry of free NADPH oxidation in liver microsomes.
Topics: Animals; Hydrogen Peroxide; Kinetics; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rabbits; Superoxides | 1982 |
8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes.
Topics: Animals; Cobalt; Dronabinol; Isomerism; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; NADP; Phenobarbital | 1982 |
Rat liver microsomal transformation of ethene to oxirane in vitro.
Topics: Alkylation; Animals; Biotransformation; Cobalt; Ditiocarb; Ethylene Oxide; Ethylenes; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Oxidation-reduction potential of soluble and membrane-bound rabbit liver microsomal cytochrome P-450 LM2.
Topics: Animals; Cold Temperature; Cytochrome P-450 Enzyme System; Dithionite; Electron Spin Resonance Spectroscopy; Intracellular Membranes; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits; Solubility | 1983 |
Reducing equivalents for mixed function oxidation in periportal and pericentral regions of the liver lobule in perfused livers from normal and phenobarbital-treated rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme System; Fasting; Female; Kinetics; Liver; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Oxygenases; Perfusion; Phenobarbital; Potassium Cyanide; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Ethanol-inducible cytochrome P-450 is more susceptible to in vitro carbon tetrachloride-mediated destruction than phenobarbital-inducible and beta-naphthoflavone-inducible cytochromes P-450.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Free Radicals; Male; Microsomes, Liver; NADP; Nitroanisole O-Demethylase; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Rat liver aldehyde dehydrogenase. II. Isolation and characterization of four inducible isozymes.
Topics: Aldehyde Dehydrogenase; Animals; Enzyme Induction; Female; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Liver; Male; Molecular Weight; NADP; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1984 |
Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: II. The interrelation between lipid peroxidation and proteolytic degradation of cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Hydrolysis; Kinetics; Lipid Peroxides; Liver; Male; Membranes; Methylcholanthrene; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Trypsin | 1984 |
1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Pyrenes; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1984 |
Mechanism for isaxonine hepatitis. I. Metabolic activation by mouse and human cytochrome P-450.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Kidney; Kinetics; Male; Mice; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Piperonyl Butoxide; Pyrimidines | 1984 |
7-Ethoxycoumarin O-de-ethylase activity in rat brain microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Brain; Enzyme Induction; Male; Methylcholanthrene; Microsomes; NAD; NADP; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. 8. Stereoselectivity in metabolic intermediary complex formation with a series of chiral 2-substituted 1-phenyl-2-aminoethanes.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Cytochromes; Kinetics; Male; Microsomes, Liver; NADP; Phenethylamines; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1984 |
The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro.
Topics: Acetaminophen; Amino Acids; Animals; Benzoquinones; Caseins; Cysteine; Glutathione; Imines; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NADP; Phenobarbital; Proteins; Serum Albumin, Bovine | 1984 |
Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450.
Topics: Animals; Benzene Derivatives; Benzoflavones; Benzopyrenes; Cytochrome P-450 Enzyme System; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Phenols; Rats; Spectrophotometry | 1980 |
Characteristics of the activation of cyclophosphamide to a mutagen by rat liver.
Topics: Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Flavonoids; In Vitro Techniques; Liver; Male; Metyrapone; Mutagens; NADP; Phenobarbital; Proadifen; Rats; Salmonella typhimurium | 1980 |
Pyridine nucleotide involvement in rat hepatic drug metabolism. The influence of NADH on the NADPH kinetics of phenobarbital pre-treated rat microsomes.
Topics: Animals; Cytochrome b Group; Cytochromes; Dealkylation; Electron Transport; Enzyme Induction; Kinetics; Liver; Male; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital; Rats | 1980 |
Effect of polyamine on microsomal cytochrome P-450 stimulation of rate and improved coupling of NADPH oxidation to hydroxylation.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rabbits; Spermine | 1981 |
Practolol metabolism. III. Irreversible binding of [14C]practolol metabolite(s) to mammalian liver microsomes.
Topics: Animals; Biotransformation; Blood Proteins; Callitrichinae; Cricetinae; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Microsomes, Liver; NADP; Phenobarbital; Practolol; Protein Binding; Rats; Rats, Inbred Strains | 1981 |
Selective inactivation of NADPH-cytochrome P-450 (c) reductase by diazotized 3-aminopyridine adenine dinucleotide phosphate.
Topics: Animals; Binding, Competitive; Kinetics; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Nucleotides; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Structure-Activity Relationship | 1981 |
Anaerobic dehalogenation of halothane by reconstituted liver microsomal cytochrome P-450 enzyme system.
Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Halothane; Kinetics; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits | 1981 |
Cytochrome P450 oxidase activity and its role in NADPH dependent lipid peroxidation.
Topics: Animals; Kinetics; Lipid Peroxides; Male; Malondialdehyde; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits.
Topics: Acetamides; Allylisopropylacetamide; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Microsomes, Liver; NADP; Phenobarbital; Rabbits | 1983 |
Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Metyrapone; Microsomes, Liver; NADP; Ochratoxins; Phenobarbital; Rabbits | 1983 |
Regulation of monooxygenation during development of chick embryo liver: role of cytochrome P-450 isozymes and NADPH.
Topics: Animals; Benzphetamine; Chick Embryo; Codeine; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Ethylmorphine; Hydrogen Peroxide; Isoenzymes; Liver; NADP; Phenobarbital; Testosterone | 1983 |
[Complete stoichiometry of free NADP-H oxidation in liver microsomes].
Topics: Animals; Free Radicals; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mathematics; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits | 1983 |
Comparative studies on the cumene hydroperoxide- and NADPH-supported N-oxidation of 4-chloroaniline by cytochrome P-450.
Topics: Aniline Compounds; Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Female; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits; Spectrophotometry | 1983 |
Mutagenic activation of 2,4-diaminoanisole and 2-amino-fluorene by isolated rat liver nuclei and microsomes.
Topics: Animals; Anisoles; Benzoflavones; beta-Naphthoflavone; Cell Nucleus; Cobalt; Flavonoids; Fluorenes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mutagens; NADP; Phenobarbital; Phenylenediamines; Rats; Salmonella typhimurium | 1980 |
Effect of cadmium and phenobarbital on cerebral aldehyde reductase.
Topics: Alcohol Oxidoreductases; Animals; Brain; Cadmium; Cytosol; Kinetics; NADP; Phenobarbital; Rats | 1982 |
Suicidal inactivation of hepatic cytochrome P-450 in vitro by some aliphatic olefins.
Topics: Alkenes; Animals; Cytochrome P-450 Enzyme Inhibitors; Kinetics; Male; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Time Factors | 1982 |
Comparative study on oxidation of aromatic compounds by rat liver and rabbit lung microsomes.
Topics: Animals; Energy Metabolism; Hydroxylation; Kinetics; Lung; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Phenobarbital; Rabbits; Rats | 1982 |
Omega-hydroxylation of acyclic monoterpene alcohols by rat lung microsomes.
Topics: Alcohols; Animals; Flavonoids; Hydroxylation; Lung; Male; Microsomes; NADP; Oxygen; Phenobarbital; Rats | 1982 |
Cholesterol HDL in phenobarbital-treated male and female Wistar rats.
Topics: Animals; Cholesterol; Cholesterol, HDL; Female; Lipoproteins, HDL; Liver; Male; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Sex Factors | 1981 |
Metabolism of alpha-naphthoflavone by rat liver microsomes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Flavonoids; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Spectrum Analysis; Time Factors | 1981 |
Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes.
Topics: Animals; Carmustine; In Vitro Techniques; Kinetics; Lomustine; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred F344 | 1981 |
Specific labelling of microsomal proteins by reactive intermediates generated from 2-acetylaminofluorene in vitro.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytosol; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains | 1981 |
Cholesterol HDL in G-6-PD deficient newborn infants following phenobarbital administration.
Topics: Cholesterol; Cholesterol, HDL; Cytochrome P-450 Enzyme System; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant, Newborn; Lipoproteins, HDL; NADP; Phenobarbital | 1981 |
Oxidation-reduction states of pyridine nucleotide and cytochrome P-450 during mixed-function oxidation in perfused rat liver.
Topics: Aminopyrine; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Liver; Male; Mixed Function Oxygenases; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
The effects of dietary lipid and phenobarbitone on the production and utilization of NADPH in the liver. A combined biochemical and quantitative cytochemical study.
Topics: Animals; Cytochrome P-450 Enzyme System; Dietary Fats; Fatty Acid Synthases; Glucosephosphate Dehydrogenase; Liver; Male; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Tissue Distribution | 1981 |
The mechanism of the reductive dehalogenation of polyhalogenated compounds by microsomal cytochrome P450.
Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Hydrocarbons, Halogenated; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Reaction of microsomal and cytosolic enzymes with N-arylacetohydroxamic acids in the presence of oxygen.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Biotransformation; Cytosol; Hydroxamic Acids; Kinetics; Liver; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Rabbits; Rats | 1981 |
Nuclear metabolism. I. Determination of styrene monooxygenase activity in rat liver nuclei.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; In Vitro Techniques; Liver; Male; Metyrapone; Microsomes, Liver; NAD; NADP; Nuclear Envelope; Phenobarbital; Rats; Styrenes | 1980 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Enhancement by cyanide of aniline p-hydroxylation activity in rat liver microsomes.
Topics: 2,2'-Dipyridyl; Acetone; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cyanides; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Potassium Cyanide; Rats | 1980 |
Inactivation of purified rat liver cytochrome P-450 by chloramphenicol.
Topics: Amino Acids; Animals; Carbon Monoxide; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; NADP; Phenobarbital; Rats | 1980 |
Comparison of ratios of covalent binding to total metabolism of the pulmonary toxin, 4-ipomeanol, in vitro in pulmonary and hepatic microsomes, and the effects of pretreatments with phenobarbital or 3-methylcholanthrene.
Topics: Alkylating Agents; Animals; Biotransformation; Furans; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Rats; Terpenes | 1980 |
Inactivation of hepatic cytochrome P-450 by allenic substrates.
Topics: Alkadienes; Animals; Cytochrome P-450 Enzyme Inhibitors; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats | 1980 |
Microsomal peroxidase activities--effect of cumene hydroperoxide on the pyridine nucleotide reduced cytochrome b5 steady state.
Topics: Animals; Benzene Derivatives; Cytochromes; Cytochromes b5; In Vitro Techniques; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Peroxidases; Peroxides; Phenobarbital; Rats | 1980 |
Enzymic formation of dehydrogenated and hydroxylated metabolites from lysergic acid diethylamide by rat liver microsomes.
Topics: Anaerobiosis; Animals; Biotransformation; Hydroxylation; In Vitro Techniques; Lysergic Acid Diethylamide; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Inhibition of mixed-function oxidation of p-nitroanisole in perfused rat liver by 2,4-dinitrophenol.
Topics: 2,4-Dinitrophenol; 6-Aminonicotinamide; Animals; Dinitrophenols; Fasting; Female; Liver; NAD; NADP; Nitroanisole O-Demethylase; Oxidation-Reduction; Oxidoreductases; Perfusion; Phenobarbital; Rats | 1980 |
Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes.
Topics: 2-Acetylaminofluorene; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rabbits; Rats; Species Specificity | 1980 |
Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P-450 system.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Tetrachloroethylene | 1980 |
Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Kinetics; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes.
Topics: Animals; Antigen-Antibody Reactions; Cytochrome P-450 Enzyme System; Electron Transport; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats | 1980 |
Interaction of organophosphorus analogues of amino acids with P450.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Models, Molecular; NADP; Organophosphonates; Organophosphorus Compounds; Phenobarbital; Phosphorus Acids; Rabbits; Spectrum Analysis, Raman; Substrate Specificity | 1995 |
beta-Naphthoflavone- and self-induced metabolism of 3,3',4,4'-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Gas Chromatography-Mass Spectrometry; Hydroxylation; Liver; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Pregnancy; Rats; Rats, Wistar | 1995 |
Isoflurane and cytochrome b5 stimulation of 2-chloro-1,1-difluoroethene metabolism by reconstituted rat CYP2B1 and CYP2C6.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Chlorofluorocarbons; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Cytochromes b5; Fluorides; Isoflurane; Male; Microsomes, Liver; NADP; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Steroid 21-Hydroxylase; Steroid Hydroxylases | 1995 |
Activation of alkylhydrazines to free radical intermediates by ethanol-inducible cytochrome P-4502E1 (CYP2E1).
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Ethanol; Free Radicals; Humans; Hydrazines; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; Spin Labels | 1995 |
P450 enzyme CYP2B catalyzes the detoxification of diisopropyl fluorophosphate.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Clotrimazole; Cricetinae; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Isoflurophate; Isoquinolines; Male; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases | 1995 |
Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen.
Topics: Animals; Benzene Derivatives; Biotransformation; DNA; DNA Adducts; Female; Horseradish Peroxidase; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Sprague-Dawley; Tamoxifen | 1995 |
Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Division; Cells, Cultured; Cocaine; Cytochrome P-450 Enzyme System; DNA; DNA Damage; Flow Cytometry; Glutathione; Isocitrate Dehydrogenase; Liver; Liver Regeneration; Male; Malondialdehyde; Mice; NADP; Necrosis; Phenobarbital; Ploidies; Polyploidy; Time Factors | 1994 |
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 1994 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
Cytochrome P450 destruction and radical scavenging by benzene and its metabolites. Evidence for the key role of quinones.
Topics: Animals; Benzene; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Free Radical Scavengers; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Quinones; Rats; Rats, Wistar; Time Factors | 1994 |
Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species.
Topics: Animals; Catalase; Cytochrome P-450 Enzyme System; Ethanol; Glutathione Peroxidase; Male; Microsomes, Liver; NADP; Pentetic Acid; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Toluene | 1994 |
DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems.
Topics: Animals; Benzene Derivatives; DNA; Female; Humans; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Tamoxifen | 1994 |
Metabolism of allylnitrile to cyanide: in vitro studies.
Topics: Animals; Biotransformation; Cyanides; Hydrogen-Ion Concentration; Magnesium Chloride; Male; Microsomes, Liver; NADP; Nitriles; Phenobarbital; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds | 1993 |
An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes.
Topics: Adult; Animals; Ascorbic Acid; Base Sequence; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Glutathione; Humans; Male; Mice; Microsomes, Liver; Mitotic Index; Molecular Sequence Data; Monocytes; NADP; Naphthalenes; Phenobarbital; Polymerase Chain Reaction; Sister Chromatid Exchange; Trichloroepoxypropane | 1993 |
Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro.
Topics: Aerobiosis; Anaerobiosis; Animals; Biotransformation; Cell Membrane; Halothane; Leukotriene B4; Lipid Peroxidation; Lipoxygenase Inhibitors; Liver; Male; Models, Biological; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Rats, Sprague-Dawley | 1994 |
Interaction of fluoroethane chlorofluorocarbon (CFC) substitutes with microsomal cytochrome P450. Stimulation of P450 activity and chlorodifluoroethene metabolism.
Topics: Animals; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cytochrome P-450 Enzyme System; Halothane; Hydrocarbons, Fluorinated; Male; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Rabbits; Solubility | 1993 |
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Chromatography, High Pressure Liquid; Cytochrome c Group; Enzyme Induction; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Kinetics; Male; Mathematics; Mitochondria, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Onium Compounds; Phenobarbital; Rats; Rats, Wistar; Spectrometry, Mass, Fast Atom Bombardment | 1993 |
Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers.
Topics: Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Dexamethasone; Erythromycin; Humans; In Vitro Techniques; Macrolides; Male; Microsomes, Liver; NADP; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Troleandomycin | 1993 |
Inactivation of phenobarbital-inducible rabbit-liver microsomal cytochrome P-450 by allylisopropylacetamide: impact on electron transfer.
Topics: Allylisopropylacetamide; Amino Acids; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Electron Transport; Enzyme Induction; Heme; Microsomes, Liver; NAD; NADP; Phenobarbital; Proteins; Rabbits | 1993 |
Metabolism of 2-acetylaminofluorene. I. Metabolism in vitro of 2-acetylaminofluorene and 2-acetylaminofluoren-9-one by hepatic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cytosol; Female; Hydroxylation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1993 |
Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.
Topics: Acetaldehyde; Adenosine; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethylene Dibromide; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Isoenzymes; Kinetics; Male; Microsomes, Liver; Molecular Structure; NADP; Phenobarbital; Pyrazoles; Rats; Rats, Wistar; Temperature | 1996 |
Effect of cimetidine on hepatic cytochrome P450: evidence for formation of a metabolite-intermediate complex.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme System; Histamine H2 Antagonists; Liver; Male; NADP; Phenobarbital; Rats; Rats, Wistar; Spectrometry, Fluorescence | 1995 |
Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver.
Topics: Animals; Arachidonic Acid; Benzene Derivatives; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Induction; Ferric Compounds; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital | 1996 |
Cisplatin metabolites and their toxicity on isolated cochlear outer hair cells in vitro.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Cochlea; Electrophoresis, Capillary; Guinea Pigs; Hair Cells, Auditory, Outer; Hot Temperature; Hypnotics and Sedatives; Liver; NADP; Oxygenases; Phenobarbital | 1996 |
Cytochrome P-450 and free radical generation in rat liver microsomes under the influence of prostaglandin E1.
Topics: Acetone; Alprostadil; Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Down-Regulation; Ethanol; Free Radicals; Hydrogen Peroxide; Luminescent Measurements; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Phenobarbital; Rats; Rats, Inbred Strains; Starvation; Superoxide Dismutase | 1996 |
Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda).
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Haemonchus; Kinetics; Larva; Microsomes; Mixed Function Oxygenases; NADP; Phenobarbital; Piperonyl Butoxide; Sheep; Substrate Specificity | 1997 |
In vitro metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in the Fischer 344 rat and New Zealand white rabbit.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fungicides, Industrial; In Vitro Techniques; Kidney; Liver; Male; Molecular Structure; NADP; Phenobarbital; Rabbits; Rats; Rats, Inbred F344; Succinates; Succinimides; Xenobiotics | 1996 |
Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450.
Topics: Alkenes; Anaerobiosis; Animals; Biotransformation; Carbon Monoxide; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cyclic N-Oxides; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione; Heme; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Pyridines; Rats; Rats, Wistar | 1996 |
Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid.
Topics: Acetone; Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Carcinogens; Catalysis; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Isoenzymes; Lauric Acids; Microsomes, Liver; NADP; Phenobarbital; Rabbits; Rifampin; Stereoisomerism | 1998 |
Genistein metabolism in liver microsomes of Wistar and mutant TR(-)-rats.
Topics: Animals; Anion Transport Proteins; Antineoplastic Agents; Blotting, Western; Carrier Proteins; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dexamethasone; Genistein; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Mutation; NADP; Phenobarbital; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet | 1998 |
Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Topics: Acrylonitrile; Animals; Benzimidazoles; Cyanides; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Hydrogen-Ion Concentration; Kidney; Male; Methylcholanthrene; Microsomes; NADP; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfhydryl Compounds; Temperature | 1999 |
Analysis of nitrite/nitrate in biological fluids: denitrification of 2-nitropropane in F344 rats.
Topics: Animals; Blood Chemical Analysis; Carcinogens; Inactivation, Metabolic; Male; Microsomes, Liver; NADP; Nitrates; Nitrites; Nitroparaffins; Phenobarbital; Propane; Rats; Rats, Inbred F344 | 2000 |
Metabolite-intermediate complexation and inhibition of microsomal CYP3A in rat liver by diltiazem.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Desipramine; Dexamethasone; Diltiazem; Enzyme Inhibitors; Immunoblotting; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Wistar; Spectrophotometry; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone | 2000 |
Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver.
Topics: Animals; Benzene Derivatives; Benzoquinones; Biotransformation; Carbon Isotopes; Chloranil; Cytosol; Environmental Pollutants; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Horseradish Peroxidase; Hydrogen Peroxide; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Quinones; Rats; Species Specificity | 2001 |
Effect of alpha-methyldopa on pentoxyresorufin O-dealkylation in liver microsomes from rats treated with phenobarbital.
Topics: Animals; Ascorbic Acid; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1 Inhibitors; Dopamine; Enzyme Inhibitors; Glutathione; Levodopa; Lipid Peroxidation; Male; Methyldopa; Microsomes, Liver; NADP; Oxazines; Phenobarbital; Rats; Rats, Wistar | 2001 |
Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts.
Topics: Acetylcholinesterase; Animals; Aryl Hydrocarbon Hydroxylases; Brain; Cholinesterase Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Enzyme Induction; Excitatory Amino Acids; Isoenzymes; Male; Methyl Parathion; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Wistar | 2001 |
Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
Topics: Animals; Benzopyrenes; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; NADP; Phenobarbital; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 2002 |
Bilirubin and uroporphyrinogen oxidation by induced cytochrome P4501A and cytochrome P4502B. Role of polyhalogenated biphenyls of different configuration.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Bilirubin; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Molecular Conformation; NADP; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Oxygen; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Wistar; Uroporphyrinogens | 2002 |
Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Bicyclic Monoterpenes; Cell Line; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2B6; Cytochrome P450 Family 2; Enzyme Activation; Enzyme Induction; Female; Gene Expression; Humans; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Terpenes | 2003 |
[EFFECT OF BARBITURATES ON THE NON-ENZYMATIC OXIDATION OF NADH CATALYZED BY IRRADIATED FLAVIN].
Topics: Barbiturates; Dinitrocresols; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; NAD; NADP; Oxidation-Reduction; Pharmacology; Phenobarbital; Ultraviolet Rays | 1963 |
THE INFLUENCE OF PHENOBARBITAL ADMINISTRATION UPON THE "SOLUBLE" NADP-REQUIRING ENZYMES IN LIVER.
Topics: Aminopyrine; Benzopyrenes; Citrates; Diphenhydramine; Ethionine; Fluorouracil; Gluconates; Hexosephosphates; Isocitrate Dehydrogenase; Liver; Mercaptopurine; Methylcholanthrene; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylalanine; Rats; Research; Uracil | 1964 |
KINETICS OF DRUG METABOLISM BY HEPATIC MICROSOMES.
Topics: Acetanilides; Chlorpromazine; Hexobarbital; Kinetics; Liver; Metabolism; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Morphine; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylbutazone; Rats; Research; Zoxazolamine | 1964 |
The effect of temperature on monoxygenase reactions in the microsomal membrane.
Topics: Aminopyrine; Animals; Anisoles; Benzphetamine; Catalysis; Cell Membrane; Ethylmorphine; Ethylmorphine-N-Demethylase; Glycerol; Kinetics; Male; Methylation; Microsomes; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Long-Evans; Substrate Specificity; Temperature; Time Factors | 1977 |
Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).
Topics: Animals; Binding, Competitive; Cell Division; Cytochrome P-450 Enzyme System; Endocrine Disruptors; Enzyme Inhibitors; Estradiol; Flame Retardants; Halogenated Diphenyl Ethers; Hydroxylation; Male; Microsomes, Liver; NADP; Phenobarbital; Polybrominated Biphenyls; Prealbumin; Rats; Rats, Wistar; Sulfotransferases; Thyroxine | 2008 |
Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.
Topics: Animals; Apoproteins; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Crystallization; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Glutathione; Heme; Hormone Antagonists; Humans; In Vitro Techniques; Isoenzymes; Microsomes, Liver; Mifepristone; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry | 2009 |
A 28-day whole-body inhalation study to evaluate octamethylcyclotetrasiloxane (D4) absorption/distribution in two rat strains.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochromes c; Epoxide Hydrolases; Female; Male; NADP; Phenobarbital; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Siloxanes | 2022 |