Compounds > phenobarbital

phenobarbital and n-acetyl-4-benzoquinoneimine

phenobarbital has been researched along with n-acetyl-4-benzoquinoneimine in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kalhorn, TF; Lee, CA; Nelson, SD; Slattery, JT1
Baillie, TA; Dahlin, DC; Nelson, SD; Streeter, AJ1
Jaw, S; Jeffery, EH1
Marx, J1
Chua, SS; Huang, W; Moore, DD; Wei, P; Zhang, J1
Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T1

Other Studies

6 other study(ies) available for phenobarbital and n-acetyl-4-benzoquinoneimine

ArticleYear
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline

1990
The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro.
    Chemico-biological interactions, 1984, Volume: 48, Issue:3

    Topics: Acetaminophen; Amino Acids; Animals; Benzoquinones; Caseins; Cysteine; Glutathione; Imines; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NADP; Phenobarbital; Proteins; Serum Albumin, Bovine

1984
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Activation; Female; Imines; Isoenzymes; Kinetics; Liver Diseases; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital

1993
Toxicology. Protecting liver from painkiller's lethal dose.
    Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Androstanols; Animals; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Drug Overdose; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Liver Failure, Acute; Mice; Mice, Transgenic; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2002
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
    Science (New York, N.Y.), 2002, Oct-11, Volume: 298, Issue:5592

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors

2002
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
    Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glutathione; Imines; Liver; Liver Diseases; Magnetic Resonance Imaging; Male; Metabolomics; Oxidation-Reduction; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344

2011