phenobarbital has been researched along with morphinans in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (98.36) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baron, J; Isaacson, EL; LoSpalluto, J; Masters, BS; Taylor, WE | 1 |
| Adamson, RH; Call, JB; Gram, TE; Guarino, AM; Schroeder, DH | 1 |
| Greene, FE; Page, JG; Passananti, GT; Vesell, ES | 1 |
| Fujita, T; Mannering, GJ | 1 |
| Greene, FE; Stevens, JT | 1 |
| Kuwahara, S; Mannering, GJ; Omura, T | 1 |
| Patel, JM; Pawar, SS | 3 |
| Strickhart, FS; Yang, CS | 1 |
| Anthony, LE | 1 |
| Alvares, AP; Bickers, DR; Kappas, A | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Breyer, U | 1 |
| Hildebrandt, AG; Roots, I | 1 |
| Borowski, R; Schlede, E | 1 |
| Wilson, JT | 1 |
| Conney, AH; Kuntzman, R; Lu, AY; Somogyi, A; West, S | 1 |
| Franklin, MR | 1 |
| Campbell, TC; Hayes, JR; Mgbodile, MU | 1 |
| Kourounakis, P; Tuchweber, B; Werringloer, J | 1 |
| Coon, MJ; Lu, AY; Strobel, HW | 1 |
| Baron, J; Tephly, TR | 1 |
| Estabrook, RW; Franklin, MR | 1 |
| Estabrook, RW; Hildebrandt, A | 1 |
| Davis, DC; Gillette, JR; Gram, TE; Reagan, RL; Schroeder, DH | 1 |
| Davis, DC; Gram, TE; Guarino, AM; Reagan, RL; Schroeder, DH | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, SB | 1 |
| Allen, LM; Creaven, PJ | 1 |
| Gladtke, E; Hiller, HJ | 1 |
| Jacob, ST; Scharf, MB; Vessel, ES | 1 |
| Hildebrandt, AG | 1 |
| Alvares, AP; Mannering, GJ; Parli, CJ | 1 |
| Darby, FJ | 2 |
| Bick, M; Fishbein, L | 1 |
| Basu, TK; Harris, RG; Stewart, PS; Williams, DC | 1 |
| Darby, J | 1 |
| Feller, DR; Lubawy, WC | 1 |
| Breckenridge, A; Davies, DS; Davies, L; Orme, M | 1 |
| Miranda, CL; Webb, RE | 1 |
| Feller, DR; Lewis, NJ; Poochikian, GK; Witiak, DT | 1 |
| Erickson, RR; Holtzman, JL; Montgomery, MR | 1 |
| Chhabra, RS; Fouts, JR | 1 |
| Neal, RA; Roth, JA | 1 |
| Smith, PB; Wade, AE; Wu, B | 1 |
| Lavigne, JG; Marchand, C | 1 |
| Alvares, AP; Kappas, A | 1 |
| Baba, N; Greenberger, NJ; Salsburey, D; Thomas, FB | 1 |
| Breckenridge, A; Davies, DS; Ohnhaus, EE; Thorgeirsson, SS | 1 |
| Banks, GS; Lundeen, PB; Ruddon, RW | 1 |
| Breckenridge, A; Orme, M | 1 |
| Page, JG; Vesell, ES | 1 |
| Gray, WD; Osterberg, AC; Scuto, TJ | 1 |
| Alvares, AP; Mannering, GJ | 1 |
| Furner, RL; McCarthy, JS; Stitzel, RE; Van Dyke, K | 1 |
| Culp, HW; Gibson, WR; Marshall, FJ; McMahon, RE; Miller, WM; Mills, J | 1 |
| Mannering, GJ; Sladek, NE | 2 |
| Benetti, D; Citti, L; Del Monte, M; Gervasi, PG; Turchi, G | 1 |
| Chou, CY; Chou, YC; Tien, JH; Ueng, YF | 1 |
1 review(s) available for phenobarbital and morphinans
| Article | Year |
|---|---|
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.
Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Ethylamines; Hydrogen-Ion Concentration; In Vitro Techniques; Isocitrate Dehydrogenase; Methylation; Metyrapone; Microsomes, Liver; Morphinans; Oxidation-Reduction; Phenobarbital; Proadifen; Pseudomonas; Rats; Spectrum Analysis | 1972 |
60 other study(ies) available for phenobarbital and morphinans
| Article | Year |
|---|---|
Immunochemical studies on electron transport chains involving cytochrome P-450. I. Effects of antibodies to pig liver microsomal reduced triphosphopyridine nucleotide-cytochrome c reductase and the non-heme iron protein from bovine adrenocortical mitochon
Topics: Adrenal Glands; Animals; Antibodies; Antigen-Antibody Reactions; Cattle; Chromatography, DEAE-Cellulose; Cytochromes; Electron Transport; Female; Ferredoxins; gamma-Globulins; Immune Sera; Immunochemistry; Immunodiffusion; Immunoglobulins; Male; Microsomes; Microsomes, Liver; Mitochondria; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rabbits; Rats; Swine | 1971 |
Studies of hepatic microsomal enzymes, serum proteins, and serum cholesterol after treatment of rats with L-asparaginase alone or in combination with phenobarbital.
Topics: Aniline Compounds; Animals; Anticholesteremic Agents; Asparaginase; Benzoates; Blood Proteins; Enzyme Induction; Escherichia coli; gamma-Globulins; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Oxidoreductases; Phenobarbital; Rats; Serum Albumin | 1970 |
Genetic control of drug levels and of the induction of drug-metabolizing enzymes in man: individual variability in the extent of allopurinol and nortriptyline inhibition of drug metabolism.
Topics: Adult; Allopurinol; Aniline Compounds; Animals; Antipyrine; Coffee; Cytochromes; Dicumarol; Ethanol; Female; Half-Life; Humans; Kinetics; Male; Mathematics; Metabolism; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Morphinans; Nortriptyline; Oxidoreductases; Pharmacogenetics; Phenobarbital; Phenylbutazone; Pregnancy; Rats; Smoking; Statistics as Topic; Tea; Twins; White People | 1971 |
Electron transport components of hepatic microsomes. Solubilization, resolution, and recombination to reconstitute aniline hydroxylase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Chloromercuribenzoates; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats; Solubility; Structure-Activity Relationship; Vitamin K | 1973 |
Response of the mixed function oxidase system of rat hepatic microsomes to parathion and malathion and their oxygenated analogs.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Activation; Hydroxylation; In Vitro Techniques; Malathion; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Oxidoreductases, N-Demethylating; Paraoxon; Parathion; Phenobarbital; Protein Binding; Rats; Spectrophotometry, Ultraviolet | 1973 |
Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes.
Topics: Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electrophoresis, Polyacrylamide Gel; Immunoglobulins; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rabbits; Rats | 1974 |
Riboflavin and drug metabolism in adult male and female rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Body Weight; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Electron Transport; Female; In Vitro Techniques; Liver; Male; Microsomes, Liver; Morphinans; NADP; Organ Size; Phenobarbital; Proteins; Rats; Riboflavin Deficiency; Sex Factors; Time Factors | 1974 |
Inhibition of hepatic mixed function oxidase activity by propyl gallate.
Topics: Aging; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Benzphetamine; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Diet; Gallic Acid; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
Effects of protein-calorie malnutrition on drug metabolism in rat liver microsomes.
Topics: Animal Nutritional Physiological Phenomena; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dietary Proteins; Enzyme Induction; Lactalbumin; Male; Microsomes, Liver; Morphinans; Nutrition Disorders; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Protein Binding; Protein-Energy Malnutrition; Proteins; Rats; Spectrophotometry, Ultraviolet | 1973 |
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Enzyme Induction; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry; Stimulation, Chemical | 1973 |
Drug metabolism by hepatic microsomes from phenobarbital-treated or starved male and female rats in the presence of inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Female; Hexobarbital; Liver; Male; Methylation; Microsomes, Liver; Morphinans; Niacinamide; Organ Size; Phenobarbital; Proadifen; Rats; Starvation | 1971 |
Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism.
Topics: Aniline Compounds; Animals; Antitussive Agents; Chlorpromazine; Cytochromes; Hydroxylation; Imipramine; Male; Microsomes, Liver; Morphinans; Nitrogen Oxides; Organ Size; Phenobarbital; Phenothiazines; Piperazines; Rats | 1972 |
Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Catalysis; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Morphinans; Morphine; Oxidoreductases, N-Demethylating; Phenobarbital; Protein Binding; Rats | 1973 |
Decreased effect of phenobarbital treatment on microsomal drug metabolizing enzyme activity during gestation.
Topics: Animals; Benzopyrenes; Body Weight; Cytochrome P-450 Enzyme System; Dealkylation; Depression, Chemical; Female; Fetus; Hexobarbital; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Organ Size; Phenobarbital; Pregnancy; Pregnancy, Animal; Proteins; Rats; Sleep; Time Factors; Uterus | 1974 |
Further observations on hepatic drug metabolism in rats treated with a mixture of somatotropin, corticotropin and prolactin.
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Growth Hormone; Hexobarbital; Liver; Male; Microsomes, Liver; Morphinans; Neoplasm Transplantation; Phenobarbital; Pituitary Neoplasms; Prolactin; Rats | 1969 |
Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochrome c Group; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Organ Size; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Spectrophotometry | 1972 |
The incomplete conversion of hepatic cytochrome P-450 to P-420 by mercurials.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Hexobarbital; Hydrogen-Ion Concentration; Hydrolysis; Liver; Mercury; Microsomes, Liver; Morphinans; Niacinamide; Organomercury Compounds; Organometallic Compounds; Phenobarbital; Proteins; Rats; Spectrophotometry; Spectrum Analysis; Trypsin | 1972 |
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizng enzyme system. II. Effect of enzyme kinetics and electron transport system.
Topics: Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dietary Proteins; Electron Transport; Enzyme Induction; Kinetics; Male; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Protein Deficiency; Rats | 1973 |
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Induction; Female; Hexobarbital; Liver; Microscopy, Electron; Microsomes, Liver; Morphinans; NAD; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; Serum Albumin, Bovine; Time Factors | 1974 |
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.
Topics: Aminopyrine; Animals; Appetite Depressants; Benzphetamine; Cytochromes; Depression, Chemical; Ethers; Fatty Acids; Formaldehyde; Hexobarbital; Lipid Metabolism; Liver; Microsomes; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenethylamines; Phenobarbital; Propylamines; Rabbits; Spectrophotometry | 1969 |
Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital.
Topics: Animals; Azo Compounds; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Hydro-Lyases; Iron Isotopes; Levulinic Acids; Male; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Time Factors; Triazoles | 1969 |
On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.
Topics: Animals; Carbon Monoxide; Chlorides; Cytochromes; Dealkylation; Electron Transport; Fasting; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Magnesium; Male; Mercury; Microsomes, Liver; Morphinans; NAD; NADP; Organomercury Compounds; Osmolar Concentration; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Phenobarbital; Phosphates; Polarography; Potassium Chloride; Rats; Spectrophotometry; Time Factors; Tromethamine; Ultracentrifugation | 1971 |
Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions.
Topics: Aldehydes; Anaerobiosis; Animals; Chlorides; Colorimetry; Cytochromes; Electron Transport; Formaldehyde; Isocitrate Dehydrogenase; Kinetics; Lipid Metabolism; Magnesium; Male; Malonates; Microsomes, Liver; Models, Biological; Morphinans; Myocardium; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Spectrophotometry; Tromethamine | 1971 |
A comparison of the effects of halothane and CCl 4 on the hepatic drug metabolizing system.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochromes; Dealkylation; Halothane; Liver; Male; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats | 1971 |
Further studies on the submicrosomal distribution of drug-metabolizing components in liver. Localization in fractions of smooth microsomes.
Topics: Aniline Compounds; Animals; Centrifugation, Density Gradient; Cytochromes; Guinea Pigs; Histocytochemistry; Male; Membranes; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Phospholipids; Proteins | 1971 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
Topics: Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Flavonoids; Hemeproteins; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital; Piperazines; Proadifen; Rats; Structure-Activity Relationship; Testosterone | 1973 |
In vitro activation of isophosphamide (NSC-109724), a new oxazaphosphorine, by rat liver microsomes.
Topics: Alkylating Agents; Alkylation; Aminopyrine; Aniline Compounds; Animals; Cyclic P-Oxides; Cyclophosphamide; Dealkylation; DNA; Enzyme Activation; Ethylamines; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; NADP; Oxazines; Oxidoreductases; Phenobarbital; Phosphoranes; Proadifen; Proteins; Rats; RNA | 1972 |
[Withdrawal syndrome in a six-week-old infant treated with dihydrocodeine (author's transl)].
Topics: Codeine; Dyspepsia; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Morphinans; Phenobarbital; Substance Withdrawal Syndrome | 1974 |
Role of RNA in induction of hepatic microsomal mixed function oxidases.
Topics: Animals; Basidiomycota; Biotransformation; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; DNA-Directed RNA Polymerases; Enzyme Induction; Male; Microsomes, Liver; Morphinans; Mycotoxins; Oligopeptides; Oxidoreductases, N-Demethylating; Peptides, Cyclic; Phenobarbital; Rats; RNA, Messenger; Stimulation, Chemical; Time Factors; Uracil Nucleotides | 1974 |
Induction of drug metabolism. VI. Effects of phenobarbital and 3-methylcholanthrene administration on N-demethylating enzyme systems of rough and smooth hepatic microsomes.
Topics: Animals; Blood Proteins; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Morphinans; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Time Factors | 1973 |
Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of (ureyl- 14 C)tolbutamide by hepatic microsomal preparations from male and female rats treated with phenobarbitone.
Topics: Animals; Carbon Isotopes; Depression, Chemical; Female; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Morphinans; Pentobarbital; Phenobarbital; Rats; Sex Factors; Tolbutamide | 1972 |
Effect of certain drugs and environmental agents on microsomal enzyme systems.
Topics: Aminopyrine N-Demethylase; Animals; Anisoles; Aspirin; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Intestine, Small; Kidney; Lung; Male; Microsomes; Microsomes, Liver; Morphinans; Nitro Compounds; Oxidoreductases, N-Demethylating; Phenacetin; Phenanthrenes; Phenobarbital; Phenytoin; Rats; Transferases; Trifluoperazine | 1972 |
Effect of suramin (Bayer 205) on hepatic microsomal cytochromes P-450, b 5 , and demethylation activity in rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Dealkylation; Drug Interactions; Hexobarbital; Liver; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Rats; Suramin; Time Factors | 1973 |
Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of (ureyl- 14 C)tolbutamide by hepatic microsomal preparations from sexually-immature male and female rats treated with phenobarbitone.
Topics: Animals; Carbon Isotopes; Female; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Morphinans; Pentobarbital; Phenobarbital; Rats; Sex Factors; Tolbutamide | 1973 |
Interactions of the hexobarbital enantiomers with rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Hemeproteins; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methyltransferases; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1973 |
Dose-dependent enzyme induction.
Topics: Amobarbital; Animals; Antipyrine; Dose-Response Relationship, Drug; Enzyme Induction; Half-Life; Humans; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Secobarbital; Sleep; Warfarin | 1973 |
Effects of dietary protein quality on drug metabolism in the rat.
Topics: Anesthesia; Aniline Compounds; Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Dealkylation; Dietary Proteins; Drug Synergism; Glutens; Hexobarbital; Hydroxylation; Liver; Male; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Proadifen; Proteins; Rats; Time Factors | 1973 |
The effect of diet and phenobarbital injection on liver growth and liver microsomal enzymes in male rats.
Topics: Aniline Compounds; Animals; Diet; Dietary Fats; Dietary Proteins; Liver; Male; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Phenobarbital; Rats; Stimulation, Chemical | 1973 |
Effect of sex and age on hepatic N-demethylation and hydroxylation reactions in phenobarbital induced rats.
Topics: Acetanilides; Age Factors; Aminopyrine; Aniline Compounds; Animals; Enzyme Induction; Female; Liver; Male; Methyltransferases; Mixed Function Oxygenases; Morphinans; Morphine; Phenobarbital; Rats; Sex Factors | 1973 |
Differential effects of benzodioxane, chroman, and dihydrobenzofuran analogs of clofibrate on various parameters of hepatic drug metabolism.
Topics: Aniline Compounds; Animals; Benzofurans; Benzopyrans; Body Weight; Clofibrate; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Organ Size; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phenobarbital; Proteins; Rats; Structure-Activity Relationship | 1974 |
In vivo enrichment of hepatic microsomes with isotopic iron.
Topics: Anemia, Hypochromic; Animals; Body Weight; Cytochromes; Deficiency Diseases; Dose-Response Relationship, Drug; Enzyme Induction; Female; Iron; Iron Isotopes; Iron Radioisotopes; Liver; Microsomes, Liver; Morphinans; Organ Size; Oxygenases; Phenobarbital; Pregnancy; Rats | 1974 |
Stimulation of hepatic drug-metabolizing enzymes by DDT, polycyclic hydrocarbons or phenobarbital in adrenalectomized or castrated mice.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Castration; DDT; Dealkylation; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Methyltransferases; Mice; Mixed Function Oxygenases; Morphinans; Phenobarbital; Polycyclic Compounds; Proteins; Stimulation, Chemical; Testis | 1974 |
Spectral studies of the binding of O,O-diethyl p-nitrophenylphosphorothionate (parathion) to cytochrome P-450.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Binding Sites; Cytochromes; Hexobarbital; Male; Microsomes, Liver; Morphinans; Parathion; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry | 1972 |
Effects of ascorbic acid deficiency on kinetics of drug hydroxylation in male guinea pigs.
Topics: Aniline Compounds; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Cytochromes; Guinea Pigs; Hexobarbital; Hydroxylation; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; Organ Size; Pharmaceutical Preparations; Phenobarbital; Proteins; Time Factors | 1972 |
Effects of phenobarbital pretreatment on rat pancreas.
Topics: Amylases; Animals; Atropine; Carbon Isotopes; Enzyme Induction; Female; Hexobarbital; In Vitro Techniques; Leucine; Lipase; Microsomes; Mixed Function Oxygenases; Morphinans; Organ Size; Oxidoreductases; Pancreas; Phenobarbital; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Ribonucleases; Zoxazolamine | 1972 |
Influence of phenobarbital on the metabolism and analgesic effect of methadone in rats.
Topics: Analgesia; Animals; Biotransformation; Estradiol; Hexobarbital; Hydrocarbons; Kinetics; Male; Methadone; Microsomes, Liver; Morphinans; Phenobarbital; Rats; Testosterone | 1972 |
Effect of phenobarbital on small intestinal structure and function in the rat.
Topics: Animals; Carbon Isotopes; Cortisone; Duodenum; Ethers; Female; Glucose; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Iron; Iron Isotopes; Jejunum; Leucine; Microscopy, Electron; Microsomes; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Palmitic Acids; Phenobarbital; Rats; Sucrase | 1972 |
Changes in liver blood flow during enzyme induction.
Topics: Animals; Antipyrine; Benzopyrenes; Cytochromes; Dealkylation; Enzyme Induction; In Vitro Techniques; Liver Circulation; Male; Microsomes, Liver; Morphinans; Oxidoreductases; Pentobarbital; Phenobarbital; Rats; Sleep; Stimulation, Chemical | 1971 |
Effects of the carcinogen methylazoxymethanol acetate on protein synthesis and drug metaboliism in rat livers.
Topics: Animals; Azo Compounds; Carcinogens; Dose-Response Relationship, Drug; Enzyme Induction; In Vitro Techniques; Leucine; Liver; Male; Methanol; Methylation; Methyltransferases; Microsomes, Liver; Morphinans; Nitrosamines; Pharmaceutical Preparations; Phenobarbital; Polyribosomes; Protein Biosynthesis; Rats; Time Factors; Tritium | 1971 |
Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.
Topics: Aniline Compounds; Animals; Animals, Newborn; Carbon Isotopes; Chlorpromazine; Cytochromes; Female; Formaldehyde; Hydroxylation; Lactation; Liver; Milk; Morphinans; Oxidoreductases; Pentobarbital; Phenobarbital; Pregnancy; Rats | 1971 |
Clinical implications of enzyme induction.
Topics: Alcohols; Amobarbital; Animals; Antipyrine; Benzazepines; Blood Coagulation; Chloral Hydrate; Chlordiazepoxide; Enzyme Induction; Ethanol; Fluorometry; Half-Life; Humans; Hydrocortisone; Hypnotics and Sedatives; Ketones; Kinetics; Male; Metabolism; Microsomes, Liver; Morphinans; Nitro Compounds; Paralysis; Phenobarbital; Rats; Rheumatic Heart Disease; Secobarbital; Sleep; Time Factors; Warfarin | 1971 |
Sex and strain differences in basal and induced aniline hydroxylase and ethylmorphine N-demethylase activities from domestic and wild rats.
Topics: Aniline Compounds; Animals; Cytochromes; Enzyme Induction; Female; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Oxidoreductases; Phenobarbital; Rats; Sex Factors; Species Specificity | 1969 |
Measurement of the analgesic efficacy and potency of pentazocine by the D'Amour and Smith method.
Topics: Analgesics; Animals; Chlorpromazine; Chlorzoxazone; Cyclazocine; Hot Temperature; Male; Meperidine; Methods; Methotrimeprazine; Morphinans; Morphine; Nalorphine; Narcotic Antagonists; Pentazocine; Phenobarbital; Rats; Reaction Time | 1970 |
Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes.
Topics: Alkylation; Aniline Compounds; Animals; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Stereoisomerism | 1970 |
Effects of malarial infection on host microsomal drug-metabolizing enzymes.
Topics: Aniline Compounds; Animals; Anisoles; Blood Cell Count; Cytochromes; Endoplasmic Reticulum; Enzyme Induction; Hexobarbital; Malaria; Male; Microsomes, Liver; Morphinans; Nitrophenols; Phenobarbital; Phenylhydrazines; Plasmodium; Proteins; Rats; Reticulocytes; Sleep; Time Factors | 1970 |
Demethylation studies. VI. The inhibition of hepatic microsomal oxygenation by 2,4-dichloro(6-phenylphenoxy)ethylamine and related compounds.
Topics: Aminopyrine; Amitriptyline; Animals; Butylamines; Carbamates; Carbon Isotopes; Dextropropoxyphene; Dogs; Ethylamines; Hexobarbital; Imipramine; In Vitro Techniques; Liver; Male; Mice; Microsomes; Morphinans; Naphthalenes; Nitriles; Phenethylamines; Phenobarbital; Propylamines; Rats | 1969 |
Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.
Topics: Acetates; Animals; Benzene Derivatives; Benzopyrenes; Body Weight; Cytochromes; Glycogen; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; Organ Size; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
Dinemorphan N-demethylation by mouse liver microsomes.
Topics: Animals; Antitussive Agents; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Phenobarbital | 1984 |
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Ketoconazole; Kinetics; Linear Models; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Morphinans; Orphenadrine; Oxidoreductases, N-Demethylating; Phenobarbital | 2005 |