Compounds > phenobarbital

phenobarbital and metyrapone

phenobarbital has been researched along with metyrapone in 141 studies

Research

Studies (141)

TimeframeStudies, this research(%)All Research%
pre-1990113 (80.14)18.7374
1990's20 (14.18)18.2507
2000's5 (3.55)29.6817
2010's3 (2.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Kahl, GF; Kahl, R; Kumaki, K; Nebert, DW1
Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M1
Beyer, KH; Hilderbrandt, AG; Sadée, W; Schwandt, HJ1
Klinger, W; Muller, D1
Iida, H; Johnson, JJ; Kimura, J; Marnett, LJ1
Hiraga, K; Kawano, S1
Boobis, AR; Nebert, DW; Pelkonen, O1
Oesch, F; Tunek, A1
Flemming, K; Gertz, J; Hinkelbein, W; Mull, R1
Ebel, RE; O'keeffe, DH; Peterson, JA1
Estabrook, RW; Kawano, S; Werringloer, J1
Grudin, R; Moldèus, P; Orrenius, S; Vadi, H1
Barth, A; Bergmann, R; Klinger, W; Zaumseil, J1
Wood, AW1
Bridges, JW; Chakraborty, J; Shirkey, RS1
Jonen, HG; Kahl, GF; Kahl, R; Müller, W; Netter, KJ1
Gielen, JE; Kremers, P; Pasleau, F2
Agosin, M; Capdevila, J; Naquira, C; Paulin, J1
Burk, RF; Masters, BS1
Bridges, JW; McPherson, FJ; Parke, DV1
Abernethy, DR; Azarnoff, DL1
Dybing, E; Thorgeirsson, SS1
Burgschat, H; Netter, KJ1
McDonagh, AF; Schmid, R1
Ullrich, V; Weber, P; Wollenberg, P1
Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM1
Nastainzcyk, W; Ruf, HH; Ullrich, V1
Abou-Donia, MB; Gupta, RP1
Mangoura, SA; Maser, E; Netter, KJ; Oppermann, UC1
Burnett, AK; Craft, JA; Lambard, SE; Wolf, CR1
Bray, TM; Chen, GM; Janzen, EG; McCay, PB1
Appenroth, D; Bräunlich, H; Friese, KH; Gambaryan, S1
Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP1
Blair, IA; Jajoo, HK; Klunk, LJ; Mayol, RF1
Paine, AJ; Shean, K1
Bar-Nun, S; Oron, L1
Hirota, K; Kato, R; Kawanishi, T; Murakoshi, Y; Ohno, Y; Sunouchi, M; Takanaka, A; Yamazoe, Y1
Dixon, PA; Enwelum, MC; Okereke, SE1
Beyer, PE; Carver, BD; Ebron, MT; Kavlock, RJ; Oglesby, LA1
Bender, PE; Eckardt, RD; Leonard, TB; Newton, JF; Romano, MC; Straub, KM1
Koda, A; Konishi, Y; Mori, Y; Nagai, H; Toyoshi, K; Yamazaki, H1
Kammerer, RC; Lampe, MA1
Burnett, AK; Craft, JA; McCord, A; Morrison, V; Wolf, CR1
Gessner, T; Olson, JR; Wroblewski, VJ1
Funae, Y; Imaoka, S; Inoue, K1
De Angelis, G; Funari, E; Testai, E; Verdina, A; Vittozzi, L1
Fujita, S; Mizutani, T; Nakanishi, K; Nomura, H1
Boobis, AR; Davies, DS; Whyte, C1
Ishizawa, M; Noda, A; Noda, H; Ohno, K; Sendo, T1
Smith, AG; Stewart, FP1
Bulgheroni, A; Mayer, JM; Meyer, UA; Repond, C; Testa, B1
Brandt, I; Klasson-Wehler, E; Lund, BO1
Inoue, T; Kishi, T; Niwaguchi, T; Suzuki, S; Yasuda, T1
Hildebrandt, AG; Kahl, R; Ritter, J1
Arlotto, MP; Gorski, JR; Klaassen, CD; Parkinson, A1
Ohno, Y; Ormstad, K1
Franklin, MR; Liu, Z1
Tabarelli, S; Uehleke, H1
Kahl, GF; Kahl, R; Niedermeier, F; Tüttenberg, KH1
Grundin, R; Moldéus, P; Orrenius, S; Vadi, H1
O'Brien, PJ; Rahimtula, AD1
Aust, SD; Pederson, TC1
Bohn, W; Staudinger, H; Ullrich, V1
Hildebrandt, AG; Roots, I2
Flemming, K; Gertz, J; Mull, RH1
Rösen, P; Stier, A1
Choi, Y; Sholiton, LJ; Thrasher, K; Werk, EE1
Jubiz, W; Meikle, AW; Tyler, FH; West, CD1
Estabrook, RW; Franklin, MR; Hildebrandt, AG1
Illing, HP; Netter, KJ1
Garattini, S; Szalay, KS; Szeberenyi, S1
Leibman, KC1
Brauser, B; Sies, H1
Kahl, GF1
Frommer, U; Orrenius, S; Staudinger, H; Ullrich, V1
Borg, KO; Grundin, R; Moldéus, P; Orrenius, S; Skånberg, I; von Bahr, C1
Ikeda, M; Imamura, T; Otsuji, H2
Hildebrandt, AG1
Castro, JA; D'Acosta, N; de Castro, CR; de Ferreyra, EC; Díaz Gómez, MI1
Frommer, U; Ullrich, V; Weber, P1
Hüthwohl, B; Jonen, HG; Kahl, GF; Kahl, R1
Jonen, HG; Kahl, GF; Kahl, R1
Frommer, U; Orrenius, S; Ullrich, V1
Levine, WG1
Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC1
Blaszkowski, TP; Bogdanski, DF; Brodie, BB1
Estabrook, RW; Hildebrandt, AG; Leibman, KC1
Garattini, S; Szeberenyi, S; Tacconi, MT1
Agosin, M1
Miyauchi, M1
Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A1
Elias, AN; Gwinup, G1
Bolt, HM; Filser, JG; Schmiedel, G1
Baillie, TA; Prickett, KS1
Gadeholt, G1
Collins, MA; Conning, DM; Evans, JG; Gangolli, SD; Lake, BG; Walker, R1
Fry, JR; Horner, SA; Paterson, P1
Bassi, AM; Chiarpotto, E; Dianzani, MU; Ferro, M; Marinari, UM; Nanni, G; Poli, G1
Walsh, C; Waxman, DJ2
Lake, BG; Paine, AJ1
Crisp, DN; Orton, TC; Sorman, AE; Sturdee, AP1
Farrell, GC; Murray, M1
Akhrem, AA; Bokut', SB; Lakhvich, FA; Lis, LG; Popova, EM1
Hales, BF; Jain, R1
Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT1
Muta, E; Tsuji, H; Ullrich, V1
DePierre, JW; Meijer, J1
Aasen, AJ; Hansen, CE; Pedersen, JI; Støren, O; Størmer, FC1
Brittain, T; Costa, AK; Ivanetich, KM1
Legrum, W; Netter, KJ; Stuehmeier, G1
Parkinson, A; Robertson, LW; Safe, S1
Mitani, F; Phillips, IR; Rabin, BR; Shephard, EA1
Leibman, KC; Ortiz, E; Patel, JM1
Garattini, E; Gazzotti, G; Salmona, M1
Hollenberg, PF; Koop, DR1
Cumps, J; Dumont, P; Luu-The, V1
Inozemtseva, IA; Kretovich, VL; Lysenko, LA; Melik-Sarkisian, SS1
Grant, MH; Li, SJ; Rodgers, EH1
Barrenscheen, M; Doehmer, J; Glatt, HR; Goeptar, AR; Groot, EJ; Seidel, A; te Koppele, JM; Vermeulen, NP; Wölfel, C1
Hänninen, O; Kaliste-Korhonen, E; Kärenlampi, S; Laaksonen, M1
Kupfer, D; Mani, C; Parkinson, A; Pearce, R1
Paine, AJ; Wright, MC1
Bend, JR; Knickle, LC1
Aniya, Y; Naito, A; Shimoji, M1
Golub-Ciosk, B; Hanstein, WG; Kallweit, P; Kauczinski, D; Roos, PH1
Blain, PG; Crosbie, SJ; Williams, FM1
Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ1
Attal-Khémis, S; Dalmeyda, V; Morfin, R1
Dhawan, A; Parmar, D; Seth, PK1
Fujiwara, H; Reed, M; Thompson, DC1
Dusatti, F; Ferro, M; Gelardi, A; Morini, F; Penco, S1
Archakov, AI; Karuzina, II; Lisitsa, AV; Petushkova, NA; Zgoda, VG1
Blättler, SM; Kaufmann, MR; Meyer, UA; Rencurel, F1

Reviews

4 review(s) available for phenobarbital and metyrapone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The enzymatic formation of bilirubin.
    Annals of the New York Academy of Sciences, 1975, Apr-15, Volume: 244

    Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen

1975
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.
    Biochemical Society symposium, 1972, Volume: 34

    Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Ethylamines; Hydrogen-Ion Concentration; In Vitro Techniques; Isocitrate Dehydrogenase; Methylation; Metyrapone; Microsomes, Liver; Morphinans; Oxidation-Reduction; Phenobarbital; Proadifen; Pseudomonas; Rats; Spectrum Analysis

1972
Effects of some clinically encountered drugs on steroid synthesis and degradation.
    Metabolism: clinical and experimental, 1980, Volume: 29, Issue:6

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Drug Interactions; Ethanol; Fetus; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hydroxycholecalciferols; Liver; Metyrapone; Mitotane; Phenobarbital; Phenytoin; Rifampin; Spironolactone; Steroids

1980

Other Studies

137 other study(ies) available for phenobarbital and metyrapone

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes.
    The Journal of biological chemistry, 1976, Sep-10, Volume: 251, Issue:17

    Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Genes, Dominant; Hydrogen-Ion Concentration; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mutation; Oxygenases; Phenobarbital; Protein Binding; Protein Conformation; Spectrophotometry

1976
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 1976, Volume: 6, Issue:10

    Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes

1976
Effects of enzyme induction and inhibition on microsomal oxidation of 1,4-benzodiazepines.
    Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 294, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Hydroxylation; Male; Medazepam; Methylation; Metyrapone; Microsomes, Liver; Phenobarbital; Rats

1976
Developmental aspects of xenobiotic transformation.
    Environmental health perspectives, 1976, Volume: 18

    Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethylmorphine; Female; Glucosephosphates; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes, Liver; NAD; NADP; Niacinamide; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pregnancy; Rats; Semicarbazides

1976
Microsomal drug hydroxylase activity of Tetrahymena pyriformis.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1979, Volume: 63C, Issue:2

    Topics: Animals; Butanones; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Metyrapone; Microsomes; Phenobarbital; Spectrophotometry; Tetrahymena pyriformis

1979
Polychlorinated dibenzofurans--potent inducers of rat hepatic drug-metabolizing enzymes.
    Japanese journal of pharmacology, 1978, Volume: 28, Issue:2

    Topics: Aniline Hydroxylase; Animals; Benzofurans; Cyanides; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Liver; Male; Metyrapone; Microsomes, Liver; Nitroanisole O-Demethylase; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrum Analysis; Substrate Specificity; Time Factors

1978
Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice.
    Biochemical pharmacology, 1979, Volume: 28, Issue:1

    Topics: Animals; Benzopyrenes; Cyclohexanes; DNA; Enzyme Induction; Enzyme Inhibitors; Ethanol; Flavonoids; In Vitro Techniques; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Species Specificity

1979
Unique behaviour of benzene mono-oxygenase: activation by detergent and different properties of benzene- and phenobarbital-induced mono-oxygenase activities.
    Biochemical pharmacology, 1979, Dec-01, Volume: 28, Issue:23

    Topics: Animals; Benzene; Coumarins; Cytochrome P-450 Enzyme System; Detergents; Enzyme Activation; In Vitro Techniques; Male; Metyrapone; Oxygenases; Phenobarbital; Phenols; Rats

1979
A comparative study on the influence of cysteamine and metyrapone on mixed-function oxygenase activities in variously pretreated liver microsomes from rats and mice.
    Biochimica et biophysica acta, 1977, Apr-12, Volume: 481, Issue:2

    Topics: Acetanilides; Animals; Cysteamine; Disulfides; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Niacinamide; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Rats; Time Factors

1977
Studies of the unique nature of the cytochrome P-450 active site. Electron spin resonance spectroscopy as a probe of the hemin iron of cytochrome P-450: the influence of buffer composition, alcohols, and nitrogenous ligands.
    Archives of biochemistry and biophysics, 1977, Volume: 183, Issue:1

    Topics: Alkanesulfonates; Animals; Binding Sites; Buffers; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Hemin; Male; Membranes; Methanol; Methylcholanthrene; Metyrapone; Microsomes, Liver; Morpholines; Phenobarbital; Pseudomonas; Rats

1977
Spin state transitions of liver microsomal cytochrome P-450.
    Acta biologica et medica Germanica, 1979, Volume: 38, Issue:2-3

    Topics: Animals; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone; Protein Binding; Rats; Spectrophotometry

1979
Drug metabolism in isolated rat liver cells.
    Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00

    Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium

1975
Influence of drugs on bile acid excretion.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1978, Issue:1

    Topics: Animals; Bile; Bile Acids and Salts; Chlorpromazine; Hydroxylation; Metyrapone; Phenobarbital; Phenylbutazone; Progesterone; Rats; Time Factors

1978
Genetic regulation of coumarin hydroxylase activity in mice. Biochemical characterization of the enzyme from two inbred strains and their F1 hybrid.
    The Journal of biological chemistry, 1979, Jul-10, Volume: 254, Issue:13

    Topics: Aniline Compounds; Animals; Coumarins; Crosses, Genetic; Kinetics; Male; Metyrapone; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Species Specificity; Substrate Specificity

1979
Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver.
    Biochemical pharmacology, 1979, Sep-15, Volume: 28, Issue:18

    Topics: Animals; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Oxidoreductases; Phenobarbital; Proadifen; Rats

1979
Differential inhibition of biphenyl hydroxylation in perfused rat liver.
    Naunyn-Schmiedeberg's archives of pharmacology, 1978, Volume: 304, Issue:3

    Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Depression, Chemical; Flavonoids; Hydroxylation; Liver; Male; Metyrapone; Phenobarbital; Rats; Time Factors

1978
Is steroid-16alpha-hydroxylase supported by more than one monooxygenase?
    Biochemical and biophysical research communications, 1978, Oct-16, Volume: 84, Issue:3

    Topics: Animals; Female; Flavonoids; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Naphthalenes; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Sex Factors; Steroid Hydroxylases

1978
Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.
    Science (New York, N.Y.), 1976, Oct-08, Volume: 194, Issue:4261

    Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Cytochrome P-450 Enzyme System; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Phenobarbital; Proadifen; Ribosomes; Trypanosoma cruzi

1976
Some effects of selenium deficiency on the hepatic microsomal cytochrome P-450 system in the rat.
    Archives of biochemistry and biophysics, 1975, Volume: 170, Issue:1

    Topics: Animals; Binding Sites; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Ethylmorphine-N-Demethylase; Male; Metyrapone; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Pentobarbital; Phenobarbital; Protein Binding; Rats; Selenium; Sleep

1975
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes.
    The Biochemical journal, 1976, Mar-15, Volume: 154, Issue:3

    Topics: Acetone; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Benzopyrenes; Catechol Oxidase; Cricetinae; Cytochromes; Dactinomycin; Dioxoles; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nikethamide; Phenobarbital; Rats; Safrole

1976
Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis.
    Biochemical pharmacology, 1977, Mar-15, Volume: 26, Issue:6

    Topics: Animals; Cholesterol; Cobalt; Cytochrome P-450 Enzyme System; Desmosterol; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Metyrapone; Microsomes, Liver; Nitriles; Phenobarbital; Piperonyl Butoxide; Pregnenolone; Rats; Sterols

1977
Metabolic activation of 2,4-diamino-anisole, a hair-dye component--I. Role of cytochrome p-450 metabolism in mutagenicity in vitro.
    Biochemical pharmacology, 1977, Apr-15, Volume: 26, Issue:8

    Topics: Animals; Anisoles; Aroclors; Coloring Agents; Cytochrome P-450 Enzyme System; Female; Fetus; Flavonoids; Kidney; Liver; Lung; Male; Metyrapone; Mice; Microsomes, Liver; Mutagens; Naphthalenes; Phenobarbital; Phenylenediamines; Pregnancy; Rats; Subcellular Fractions

1977
Application of A. C.-polarography in a study of p-nitroanisole metabolism and its kinetic properties.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 201, Issue:2

    Topics: Animals; Anisoles; Catechols; Dealkylation; Hydroxylation; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Phenobarbital; Polarography; Proadifen; Proteins; Rats; Time Factors

1977
Tetrahydrofurane - an inhibitor for ethanol-induced liver microsomal cytochrome P450.
    Biochemical and biophysical research communications, 1975, Jan-02, Volume: 64, Issue:3

    Topics: Animals; Benzopyrenes; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Ethanol; Ethyl Ethers; Female; Flavonoids; Furans; Male; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Rats

1975
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
    Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00

    Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors

1975
Ligand binding of organic sulfides to microsomal cytochrome P-450.
    European journal of biochemistry, 1975, Dec-15, Volume: 60, Issue:2

    Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Kinetics; Ligands; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfides

1975
Ethanol-inducible microsomal aniline hydroxylase activity and cytochrome P-450 isozymes in adult hen liver.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1992, Volume: 101, Issue:3

    Topics: Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Catalysis; Chickens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Female; Isoenzymes; Kinetics; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital

1992
Heterogeneity of carbonyl reduction in subcellular fractions and different organs in rodents.
    Biochemical pharmacology, 1991, Dec-11, Volume: 42 Suppl

    Topics: Adrenal Glands; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Guinea Pigs; Kidney; Liver; Metyrapone; Phenobarbital; Quercetin; Rats; Rats, Inbred Strains; Subcellular Fractions

1991
The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro.
    Biochemical pharmacology, 1991, Sep-27, Volume: 42, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Benzoflavones; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Troleandomycin

1991
The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.
    Free radical research communications, 1991, Volume: 14, Issue:1

    Topics: Animals; Cyclic N-Oxides; Enzyme Induction; Kidney; Liver; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen Oxides; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Spin Labels

1991
Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats.
    Journal of applied toxicology : JAT, 1990, Volume: 10, Issue:3

    Topics: Aging; Animals; Chromates; Chromium; Cromolyn Sodium; Female; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Metyrapone; p-Aminohippuric Acid; Phenobarbital; Proteinuria; Rats; Rats, Inbred Strains

1990
Role of cytochrome P450 in the control of the production of erythropoietin.
    Life sciences, 1990, Volume: 47, Issue:2

    Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured

1990
In vitro metabolism of the antianxiety drug buspirone as a predictor of its metabolism in vivo.
    Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:8

    Topics: Animals; Buspirone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Hydroxylation; Liver; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains

1990
Immunochemical quantification of cytochrome P450IA and IIB subfamilies in the livers of metyrapone-treated rats. Relevance to the ability of metyrapone to prevent the loss of cytochrome P-450 in rat hepatocyte culture.
    The Biochemical journal, 1990, May-01, Volume: 267, Issue:3

    Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunoblotting; Isoenzymes; Liver; Male; Metyrapone; Phenobarbital; Rats; Rats, Inbred Strains

1990
Simultaneous measurements of rates of protein de novo synthesis and its steady-state levels by immunoblotting.
    Analytical biochemistry, 1989, Volume: 179, Issue:2

    Topics: Animals; Blotting, Western; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Densitometry; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Glucose; Kinetics; Metyrapone; Phenobarbital; Protein Biosynthesis; Proteins

1989
Induction of cytochrome P-450c and P-450d by metyrapone in the primary culture of rat hepatocytes.
    Japanese journal of pharmacology, 1989, Volume: 51, Issue:1

    Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoenzymes; Liver; Male; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains

1989
Influence of species, sex and drug pretreatment on the metabolism of metyrapone.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 81, Issue:1

    Topics: Animals; Anthracenes; Bufonidae; Cats; Columbidae; Ethanol; Female; Lizards; Male; Mammals; Metyrapone; Phenobarbital; Pregnenolone; Rabbits; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Turtles

1985
Co-culture of rat embryos and hepatocytes: in vitro detection of a proteratogen.
    Teratogenesis, carcinogenesis, and mutagenesis, 1986, Volume: 6, Issue:2

    Topics: Animals; Biotransformation; Cells, Cultured; Ectogenesis; Embryo, Mammalian; Female; Liver; Metyrapone; Phenobarbital; Pregnancy; Rats; Teratogens

1986
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
    The Journal of biological chemistry, 1987, Feb-05, Volume: 262, Issue:4

    Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature

1987
A comparative study of the mutagenic activation of N-nitrosopropylamines by various animal species and man: evidence for a cytochrome P-450 dependent reaction.
    Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:2

    Topics: Adult; Aniline Hydroxylase; Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; DNA; Dose-Response Relationship, Drug; Female; Humans; Liver; Macaca fascicularis; Macaca mulatta; Male; Mesocricetus; Methylation; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred Strains; Mutagens; Nitrosamines; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity

1986
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
    Carcinogenesis, 1987, Volume: 8, Issue:10

    Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole

1987
Role of specific cytochrome P-450 isoenzymes in the regio-selective metabolism of 7,12-dimethylbenz[a]anthracene in microsomes from rats treated with phenobarbital or Sudan III.
    Carcinogenesis, 1988, Volume: 9, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Cytochrome P-450 Enzyme System; Female; In Vitro Techniques; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Rats

1988
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster.
    Biochemical pharmacology, 1988, Apr-15, Volume: 37, Issue:8

    Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity

1988
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
    Archives of biochemistry and biophysics, 1988, Aug-15, Volume: 265, Issue:1

    Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dipyrone; Female; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains

1988
Xenobiotic-metabolizing enzyme systems in test fish--II. The ethylmorphine N-demethylase activity of guppy (Poecilia reticulata) liver.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1987, Volume: 88, Issue:2

    Topics: Animals; Benzoflavones; Cyprinodontiformes; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Kinetics; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Poecilia

1987
Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice.
    Research communications in chemical pathology and pharmacology, 1987, Volume: 58, Issue:1

    Topics: Animals; Biotransformation; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Cyclohexane Monoterpenes; Liver; Male; Menthol; Metyrapone; Mice; Mice, Inbred Strains; Monoterpenes; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pyridines

1987
Selective induction and inhibition of the components of 7-ethoxycoumarin O-deethylase activity in the rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:3

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains

1986
Relationship between oxidative metabolites of hydrazine and hydrazine-induced mutagenicity.
    Toxicology letters, 1986, Volume: 31, Issue:2

    Topics: Animals; Escherichia coli; Hydrazines; Male; Metyrapone; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains

1986
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
    Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13

    Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole

1986
Dual ligand binding of pyridylalkanamides to microsomal cytochrome P-450.
    Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13

    Topics: Animals; Cytochrome P-450 Enzyme System; Male; Mathematics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1986
o,p'-DDD in the mouse lung: selective uptake, covalent binding and effect on drug metabolism.
    Chemico-biological interactions, 1986, Volume: 60, Issue:2

    Topics: Adipose Tissue; Adrenal Glands; Aminopyrine; Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; DDT; Dose-Response Relationship, Drug; Isomerism; Liver; Lung; Maleates; Metyrapone; Mice; Mice, Inbred C57BL; Mitotane; Phenobarbital; Pulmonary Alveoli

1986
The metabolism of 1-phenyl-2-(N-methyl-N-furfurylamino)propane (furfenorex) in the rat in vivo and in vitro.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:2

    Topics: Animals; Appetite Depressants; Biotransformation; Carbon Monoxide; Chromatography, Gas; Chromatography, Thin Layer; Furans; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spectrophotometry

1986
Effect of the antioxidant (+)-cyanidanol-3 on H2O2 formation and lipid peroxidation in liver microsomes.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 47, Issue:1

    Topics: Animals; Benzopyrans; Catechin; Female; Guinea Pigs; Humans; Hydrogen Peroxide; In Vitro Techniques; Lipid Peroxides; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity

1985
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN).
    Carcinogenesis, 1985, Volume: 6, Issue:4

    Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors

1985
Formation, toxicity and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney.
    Archives of toxicology, 1985, Volume: 57, Issue:2

    Topics: Acrolein; Aldehydes; Animals; Biotransformation; Chromatography, High Pressure Liquid; Cyclophosphamide; Glutathione; In Vitro Techniques; Inactivation, Metabolic; Kidney; Kinetics; Liver; Male; Metyrapone; Phenobarbital; Rats; Rats, Inbred Strains; Sulfhydryl Compounds

1985
Cytochrome P-450 ligands: metyrapone revisited.
    Archives of biochemistry and biophysics, 1985, Volume: 241, Issue:2

    Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Ligands; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains

1985
N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans.
    Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 278, Issue:1

    Topics: Animals; Carbon Monoxide; Dapsone; Dogs; Erythrocytes; Female; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hydroxylation; Male; Methemoglobin; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Proteins; Rabbits; Time Factors

1973
Proceedings: Evidence for oxidative metabolism of metyrapone in rat liver microsomes.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl

    Topics: Animals; Chromatography, Thin Layer; In Vitro Techniques; Kinetics; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry, Ultraviolet

1974
A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.
    European journal of biochemistry, 1974, Jul-15, Volume: 46, Issue:2

    Topics: Adenosine Triphosphate; Alprenolol; Animals; Antimycin A; Cell Survival; Cyanides; Cytochrome P-450 Enzyme System; Cytoplasm; Gluconeogenesis; Histocytochemistry; In Vitro Techniques; Lactates; Liver; Malate Dehydrogenase; Male; Metyrapone; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Pentosephosphates; Phenobarbital; Rats; Rotenone; Spectrophotometry; Starvation; Uncoupling Agents

1974
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
    Biochemical and biophysical research communications, 1974, Sep-09, Volume: 60, Issue:1

    Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors

1974
Relationship between reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation and drug hydroxylation in rat liver microsomes.
    Biochemical pharmacology, 1974, Sep-01, Volume: 23, Issue:17

    Topics: Animals; Ascorbic Acid; Benzopyrenes; Hydroxylation; In Vitro Techniques; Lipid Metabolism; Lipids; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Peroxides; Pharmaceutical Preparations; Phenobarbital; Rats

1974
Species of cytochrome P-450 in rat liver microsomes with different stereoselectivity for the binding and monooxygenation of (+)- and (-)-methylphenobarbital.
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1971, Volume: 270, Issue:1

    Topics: Animals; Binding Sites; Cytochromes; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Receptors, Drug; Stereoisomerism

1971
Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.
    Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 277, Issue:1

    Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Catalysis; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Morphinans; Morphine; Oxidoreductases, N-Demethylating; Phenobarbital; Protein Binding; Rats

1973
Proceedings: The effect of cysteamine on the microsomal drug metabolism system.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl

    Topics: Acetanilides; Animals; Biotransformation; Cysteamine; Dealkylation; In Vitro Techniques; Kinetics; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Peroxidases; Pharmaceutical Preparations; Phenobarbital

1974
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl

    Topics: Animals; Binding Sites; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Halothane; Hexobarbital; In Vitro Techniques; Kinetics; Ligands; Metyrapone; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Photolysis; Rats; Spectrophotometry; Temperature; Tetrachloroethylene; Trichloroethylene

1974
Failure of metyrapone to inhibit 11-hydroxylation of 11-deoxycortisol during drug therapy.
    The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:9

    Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Chromatography, Paper; Chromatography, Thin Layer; Cushing Syndrome; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Metyrapone; Phenobarbital; Phenytoin; Pituitary Function Tests; Secretory Rate; Steroids

1967
Dilantin and metyrapone: a clinically significant example of enzyme induction.
    Transactions of the American Clinical and Climatological Association, 1970, Volume: 81

    Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic Reticulum; Enzyme Induction; Epilepsy; Estrogens; Glucuronates; Humans; Hyperplasia; Hypopituitarism; Liver; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Pituitary Function Tests; Pyrogens; Rats

1970
Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450-catalyzed mixed function oxidation reactions.
    Annals of the New York Academy of Sciences, 1970, Oct-05, Volume: 174, Issue:1

    Topics: Animals; Anisoles; Binding Sites; Carbon Monoxide; Cytochromes; Electron Transport; Electron Transport Complex IV; In Vitro Techniques; Methylation; Metyrapone; Microsomes, Liver; Morphine; Nitroso Compounds; Oxidation-Reduction; Phenobarbital; Rats

1970
Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.
    Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 277, Issue:1

    Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Electron Transport Complex IV; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Morphine; Oxidoreductases, N-Demethylating; Phenobarbital; Protein Binding; Rats

1973
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.
    Xenobiotica; the fate of foreign compounds in biological systems, 1974, Volume: 4, Issue:9

    Topics: Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chloromercuribenzoates; Drug Synergism; Hexobarbital; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NAD; Nitro Compounds; Oxidation-Reduction; Oxygen Consumption; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Phenols; Proadifen; Pyridines; Rats; Spectrophotometry

1974
Removal of plasma metyrapone in rats submitted to previous pharmacological treatment.
    The Journal of pharmacy and pharmacology, 1969, Volume: 21, Issue:3

    Topics: Animals; Diazepam; Female; Hydrocortisone; Liver; Meprobamate; Metyrapone; Nikethamide; Pentaerythritol Tetranitrate; Phenobarbital; Phenylbutazone; Phenytoin; Rats

1969
Effects of metyrapone on liver microsomal drug oxidations.
    Molecular pharmacology, 1969, Volume: 5, Issue:1

    Topics: Acetanilides; Aminopyrine; Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Morphine; NADP; Phenobarbital; Rats; Sleep; Stimulation, Chemical; Trichloroethylene; Tyramine

1969
Interaction of mixed function oxidase with its substrates and associated redox transitions of cytochrome P-450 and pyridine nucleotides in perfused rat liver.
    European journal of biochemistry, 1970, Volume: 15, Issue:3

    Topics: Animals; Cytochromes; Endoplasmic Reticulum; Fluorescence; Hexobarbital; Lactates; Liver; Male; Metyrapone; Microsomes, Liver; NAD; NADP; Oxidoreductases; Oxygen Consumption; Perfusion; Phenobarbital; Pyruvates; Rats; Spectrophotometry

1970
[Reductive degradation of metyrapone in rat liver].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4

    Topics: Animals; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats

1970
The monooxygenation of N-heptane by rat liver microsomes.
    Biochimica et biophysica acta, 1972, Dec-08, Volume: 280, Issue:4

    Topics: Aerobiosis; Alcohols; Alkanes; Animals; Carbon Monoxide; Chromatography, Gas; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Isomerism; Kinetics; Mass Spectrometry; Metyrapone; Microsomes, Liver; Myocardium; NADP; Oxidation-Reduction; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Swine; Vibration

1972
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.
    Acta pharmacologica et toxicologica, 1974, Volume: 35, Issue:3

    Topics: Administration, Oral; Alprenolol; Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Imipramine; Injections, Intravenous; Liver; Male; Methods; Metyrapone; Microsomes, Liver; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry; Time Factors; Tritium

1974
Comparative studies on aniline hydroxylation and p-nitrotoluene hydroxylation by the liver.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:4

    Topics: Acetamides; Acetone; Aniline Compounds; Animals; Biotransformation; Cricetinae; Depression, Chemical; Guinea Pigs; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mice; Phenobarbital; Pyridines; Rabbits; Rats; Sex Factors; Stimulation, Chemical; Toluene

1972
Comparative studies on hepatic N- and O-demethylation.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:4

    Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide

1972
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity.
    Toxicology and applied pharmacology, 1973, Volume: 25, Issue:4

    Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Proadifen; Protein Binding; Pyrazoles; Rats; Sex Factors; Statistics as Topic

1973
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1973, Volume: 354, Issue:5

    Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors

1973
Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity.
    Biochemical pharmacology, 1974, Apr-15, Volume: 23, Issue:8

    Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chemical Phenomena; Chemistry; Coenzymes; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Ligands; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pyridines; Rats; Spectrophotometry, Ultraviolet

1974
Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome P-450.
    Biochemical pharmacology, 1974, Aug-15, Volume: 23, Issue:16

    Topics: Alkanes; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrogen-Ion Concentration; In Vitro Techniques; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Solvents; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors

1974
Influence of inducers and inhibitors on the hydroxylation pattern of N-hexane in rat liver microsomes.
    FEBS letters, 1974, Apr-15, Volume: 41, Issue:1

    Topics: Alkanes; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Flavonoids; Hydroxylation; Isomerases; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats

1974
Biliary excretion of 3-methylcholanthrene as controlled by its metabolism.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 183, Issue:2

    Topics: Animals; Benzopyrenes; Bile; Depression, Chemical; Enzyme Induction; Female; Half-Life; Injections, Intravenous; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Stimulation, Chemical; Time Factors; Tritium

1972
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
    Toxicology and applied pharmacology, 1971, Volume: 19, Issue:4

    Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors

1971
Effects of enzyme induction of synthesis and catabolism of corticosterone in rats. Analysis by means of steady-state kinetics.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 179, Issue:2

    Topics: Animals; Corticosterone; Drug Interactions; Enzyme Induction; Half-Life; Injections, Intravenous; Kinetics; Male; Metyrapone; Phenobarbital; Rats; Rats, Inbred Strains; Stress, Physiological; Time Factors; Tritium

1971
Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital.
    Biochemical and biophysical research communications, 1969, Oct-22, Volume: 37, Issue:3

    Topics: Animals; Carbon Monoxide; Cytochromes; Depression, Chemical; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Models, Biological; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Stimulation, Chemical

1969
Increased metabolism of metyrapone in rats pretreated with diphenylhydantoin or phenobarbital.
    Endocrinology, 1969, Volume: 85, Issue:3

    Topics: Adrenal Glands; Animals; Biotransformation; Chromatography, Thin Layer; Enzyme Induction; Epilepsy; Liver; Metyrapone; Microsomes; Phenobarbital; Phenytoin; Pituitary Function Tests; Rats; Stimulation, Chemical

1969
The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1983, Volume: 75, Issue:2

    Topics: Aerobiosis; Animals; Metronidazole; Metyrapone; Phenobarbital; Proadifen; Species Specificity; Time Factors; Trypanosoma cruzi

1983
Conversion of procarcinogens to mutagens by the S-9 fraction from the liver of rainbow trout (Salmo gairdneri): inducibility with PCB, 3-methylcholanthrene and phenobarbital and inhibition by metyrapone and alpha-naphthoflavone.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Anthracenes; Benzo(a)pyrene; Benzoflavones; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mutagenicity Tests; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonidae; Subcellular Fractions; Temperature; Trout

1984
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.
    Archives of toxicology, 1984, Volume: 56, Issue:1

    Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine

1984
Rat liver microsomal transformation of ethene to oxirane in vitro.
    Toxicology letters, 1983, Volume: 19, Issue:3

    Topics: Alkylation; Animals; Biotransformation; Cobalt; Ditiocarb; Ethylene Oxide; Ethylenes; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains

1983
Metabolism of valproic acid by hepatic microsomal cytochrome P-450.
    Biochemical and biophysical research communications, 1984, Aug-16, Volume: 122, Issue:3

    Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Oxygen Isotopes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Valproic Acid

1984
Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases.
    Chemico-biological interactions, 1981, Mar-15, Volume: 34, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; Binding, Competitive; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnanolone; Progesterone; Rats; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Steroids; Substrate Specificity; Testosterone

1981
Ethanol and isoniazid induce a hepatic microsomal cytochrome P-450-dependent activity with similar properties towards substrate and inhibitors and different properties from those induced by classical inducers.
    Biochemical pharmacology, 1984, Oct-01, Volume: 33, Issue:19

    Topics: Animals; Cytochrome P-450 Enzyme System; Dioxolanes; Enzyme Induction; Ethanol; Imidazoles; Isoniazid; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, O-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry

1984
Sustained induction of hepatic xenobiotic metabolising enzyme activities by phenobarbitone in C3H/He mice: relevance to nodule formation.
    Toxicology, 1984, Volume: 33, Issue:2

    Topics: Animals; Carbon Radioisotopes; Enzyme Induction; Liver; Male; Metyrapone; Mice; Mice, Inbred C3H; Mixed Function Oxygenases; Phenobarbital

1984
Influence of cytochrome P-450 type on the pattern of conjugation of 7-hydroxycoumarin generated from 7-alkoxycoumarins.
    Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:11

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Ethanol; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Umbelliferones

1984
Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells.
    Cell biochemistry and function, 1984, Volume: 2, Issue:4

    Topics: Animals; Biotransformation; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Liver Neoplasms, Experimental; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Rats; Spectrum Analysis

1984
Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5.
    Biochemistry, 1983, Sep-27, Volume: 22, Issue:20

    Topics: Amino Acid Sequence; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Isoenzymes; Kinetics; Metyrapone; Microsomes, Liver; Peptide Fragments; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Substrate Specificity

1983
Induction of hepatic cytochrome P-450 and drug metabolism by metyrapone in the rat: relevance to its effects in rat-liver cell culture.
    Xenobiotica; the fate of foreign compounds in biological systems, 1983, Volume: 13, Issue:12

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Inactivation, Metabolic; Male; Metyrapone; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains

1983
Dynamics of xenobiotic metabolism by isolated rat hepatocytes using a multichannel perifusion system.
    Xenobiotica; the fate of foreign compounds in biological systems, 1983, Volume: 13, Issue:12

    Topics: Aldrin; Animals; Biochemistry; Biotransformation; Coumarins; Equipment Design; In Vitro Techniques; Liver; Male; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains

1983
Different effects of carbon tetrachloride toxicity and cirrhosis on substrate binding to rat hepatic microsomal cytochrome P-450.
    Biochemical pharmacology, 1984, Feb-15, Volume: 33, Issue:4

    Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Ethylmorphine; Liver Cirrhosis; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains

1984
[Interaction of 8-aza-16-oxasteroids with rat liver microsomal cytochrome P-450].
    Biokhimiia (Moscow, Russia), 1984, Volume: 49, Issue:4

    Topics: Animals; Azasteroids; Binding Sites; Cholesterol; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Propranolol; Rats; Rats, Inbred Strains; Spectrophotometry; Steroids, Heterocyclic; Structure-Activity Relationship

1984
Characteristics of the activation of cyclophosphamide to a mutagen by rat liver.
    Biochemical pharmacology, 1980, Volume: 29, Issue:2

    Topics: Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Flavonoids; In Vitro Techniques; Liver; Male; Metyrapone; Mutagens; NADP; Phenobarbital; Proadifen; Rats; Salmonella typhimurium

1980
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.
    Biochemical and biophysical research communications, 1980, Apr-14, Volume: 93, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship

1980
Separation and purification of liver microsomal monooxygenases from induced and untreated pigs.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1980, Volume: 361, Issue:5

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Immunodiffusion; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Spectrum Analysis; Swine

1980
Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms.
    The Journal of biological chemistry, 1982, Sep-10, Volume: 257, Issue:17

    Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Substrate Specificity

1982
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.
    Journal of steroid biochemistry, 1983, Volume: 18, Issue:4

    Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone

1983
Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes.
    Applied and environmental microbiology, 1983, Volume: 45, Issue:4

    Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Metyrapone; Microsomes, Liver; NADP; Ochratoxins; Phenobarbital; Rabbits

1983
Limitations on the metyrapone assay for the major phenobarbital inducible form of cytochrome P-450.
    Biochemical and biophysical research communications, 1982, Apr-29, Volume: 105, Issue:4

    Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Substrate Specificity

1982
Does cobalt pretreatment of mice induce a phenobarbitone-type cytochrome P-450?
    Xenobiotica; the fate of foreign compounds in biological systems, 1982, Volume: 12, Issue:5

    Topics: Animals; Biphenyl Compounds; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; Kinetics; Metyrapone; Mice; Phenobarbital

1982
Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics.
    Biochemical pharmacology, 1982, Nov-01, Volume: 31, Issue:21

    Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains

1982
Complexes of cytochrome P450 with metyrapone. A convenient method for the quantitative analysis of phenobarbital-inducible cytochrome P450 in rat liver microsomes.
    FEBS letters, 1982, Nov-08, Volume: 148, Issue:2

    Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry

1982
Specific inactivation of aniline hydroxylase by a reactive intermediate formed during acrylamide biotransformation by rat liver microsomes.
    Advances in experimental medicine and biology, 1981, Volume: 136 Pt B

    Topics: Acrylamides; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Kinetics; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats

1981
Nuclear metabolism. I. Determination of styrene monooxygenase activity in rat liver nuclei.
    Chemico-biological interactions, 1980, Volume: 29, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; In Vitro Techniques; Liver; Male; Metyrapone; Microsomes, Liver; NAD; NADP; Nuclear Envelope; Phenobarbital; Rats; Styrenes

1980
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
    Molecular pharmacology, 1980, Volume: 17, Issue:1

    Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity

1980
Metyrapone - reduced cytochrome P-450 complex: a specific method for the determination of the phenobarbital inducible form of rat hepatic microsomal cytochrome P-450.
    Biochemical and biophysical research communications, 1980, Apr-14, Volume: 93, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Spectrophotometry

1980
[Spectral studies of the cytochrome P-450 of Rhizobium lupini bacteroids].
    Doklady Akademii nauk SSSR, 1981, Volume: 256, Issue:1

    Topics: Amines; Cytochrome P-450 Enzyme System; Metyrapone; Phenobarbital; Protein Binding; Rhizobium; Spectrophotometry

1981
The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents.
    Chemico-biological interactions, 1995, Jul-14, Volume: 97, Issue:2

    Topics: Benz(a)Anthracenes; Breast Neoplasms; Cell Death; Cytochrome P-450 Enzyme System; Dexamethasone; Dicumarol; Enzyme Induction; Female; Glutathione; Glutathione Peroxidase; Humans; L-Lactate Dehydrogenase; Metyrapone; Mitoxantrone; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rifampin; Tumor Cells, Cultured; Xenobiotics

1995
The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.
    Chemico-biological interactions, 1995, Jul-14, Volume: 97, Issue:2

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cell Death; Cells, Cultured; Cricetinae; Cricetulus; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Doxorubicin; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; L-Lactate Dehydrogenase; Liver; Male; Maleates; Metyrapone; Mitomycin; Phenobarbital; Rats; Rats, Wistar; Transfection

1995
P450 enzyme CYP2B catalyzes the detoxification of diisopropyl fluorophosphate.
    Chemico-biological interactions, 1995, Mar-18, Volume: 94, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Clotrimazole; Cricetinae; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Isoflurophate; Isoquinolines; Male; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases

1995
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin

1994
Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein.
    Biochemical and biophysical research communications, 1994, Jun-15, Volume: 201, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Dexamethasone; Enzyme Induction; Humans; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Troleandomycin

1994
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
    Molecular pharmacology, 1994, Volume: 45, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles

1994
Increase in liver microsomal glutathione S-transferase activity by phenobarbital treatment of rats. Possible involvement of oxidative activation via cytochrome P450.
    Biochemical pharmacology, 1993, Nov-17, Volume: 46, Issue:10

    Topics: Amitrole; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Ethylmaleimide; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Isoniazid; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley

1993
Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes.
    Biochemical pharmacology, 1993, Jun-09, Volume: 45, Issue:11

    Topics: Animals; Antibodies; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrophotometry; Troleandomycin

1993
Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers.
    Human & experimental toxicology, 1997, Volume: 16, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Brain; Cell Line; Corn Oil; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hexanes; Hexanols; Humans; Liver; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; Muscle, Skeletal; Oxidoreductases, N-Demethylating; Phenobarbital; Random Allocation; Rats; Rats, Wistar

1997
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
    British journal of cancer, 1998, Volume: 77, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin

1998
Change of 7alpha-hydroxy-dehydroepiandrosterone levels in serum of mice treated by cytochrome P450-modifying agents.
    Life sciences, 1998, Volume: 63, Issue:17

    Topics: Animals; Brain; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dexamethasone; Dihydrotestosterone; Gas Chromatography-Mass Spectrometry; Male; Melatonin; Metyrapone; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital

1998
Evidence for O-dealkylation of 7-pentoxyresorufin by cytochrome P450 2B1/2B2 isoenzymes in brain.
    Molecular and cellular biochemistry, 1998, Volume: 189, Issue:1-2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Brain; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dealkylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Oxazines; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases

1998
Comparative metabolism, covalent binding and toxicity of BHT congeners in rat liver slices.
    Chemico-biological interactions, 2001, Nov-28, Volume: 138, Issue:2

    Topics: Alkylation; Animals; Binding Sites; Blotting, Western; Butylated Hydroxytoluene; Cattle; Cell Survival; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Glutathione; In Vitro Techniques; Insulin; Liver; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Potassium; Rats; Rats, Sprague-Dawley

2001
Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.
    Toxicology in vitro : an international journal published in association with BIBRA, 2001, Volume: 15, Issue:6

    Topics: Benzoflavones; beta-Naphthoflavone; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Inactivation, Metabolic; Keratinocytes; Methylcholanthrene; Metyrapone; Oxidoreductases; Phenobarbital; Xenobiotics

2001
Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation.
    Toxicology in vitro : an international journal published in association with BIBRA, 2002, Volume: 16, Issue:1

    Topics: alpha-Tocopherol; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); In Vitro Techniques; Iron; Lipid Peroxidation; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Protoporphyrins; Rabbits; Steroid Hydroxylases

2002
In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Jan-16, Volume: 104, Issue:3

    Topics: Animals; Cell Line; Chickens; Cytochrome P-450 Enzyme System; Cytoprotection; Down-Regulation; Enzyme Activation; Gene Expression; Membrane Potentials; Metyrapone; Mitochondrial Membranes; Phenobarbital; Phosphorylation; Phosphoserine; Protein Binding; Protein Kinases; Protein Subunits; Pyrazoles; Pyrimidines; Reactive Oxygen Species; RNA, Small Interfering

2007