phenobarbital and methyldopa

phenobarbital has been researched along with methyldopa in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (59.46)	18.7374
1990's	1 (2.70)	18.2507
2000's	8 (21.62)	29.6817
2010's	6 (16.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Glen, RC; Lowe, R; Mitchell, JB	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Daniell, HB; Ducker, TB; Salcman, M	1
Sjoerdsma, A	1
Fekete, S; Földvári, A; Gachályi, B; Káldor, A; Kállay, K	2
Hirota, Y	1
Abdella, TN; Anderson, GD; Brooks, TF; Sibai, BM; Spinnato, JA; Taslimi, M	1
Fox, GR; Virgo, BB	1
McCoubrie, M; Snaith, RP	1
Dhasmana, KM; Fokker, WA; Spilker, BA	1
Hansen, T; Jorgensen, M; Kristensen, M	1
Gachályi, B; Káldor, A; Kökény, M	2
Gazengel, J; Lhermitte, F; Marteau, R; Peterfalvi, M; Serdaru, M	1
Benjamin, MV; Goodgold, A; Ransohoff, J	1
Demeczky, M; Juvancz, P; Káldor, A; Sebestyén, K	1
Koe, BK; Weissman, A	1
Demeczky, M; Juvancz, P; Káldor, A; Palotas, J; Sebestyen, K	1
Mackie, BS	1
Batson, HM; Birchall, R; Weber, GF	1
Erõs, I; Kása, P; Pintye-Hódi, K; Siaan, M; Szabó-Révész, P	1
Szakács, T; Vereczkey, L; Veres, Z	1
MARSH, DO; MARSHALL, J; SCHNIEDEN, H	1
HANS, SF; KOPELMAN, H	1
MILLIGAN, J; TURNER, RW	1
Barton, D; Loprinzi, CL; Stearns, V	1

Reviews

1 review(s) available for phenobarbital and methyldopa

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for phenobarbital and methyldopa

Article	Year
[The effect of alpha methyldopa and phenobarbital on angiotensin sensitivity and renin activity in man]. Orvosi hetilap, 1975, Jan-05, Volume: 116, Issue:1 Topics: Adolescent; Adult; Angiotensin II; Blood Pressure; Clinical Trials as Topic; Drug Interactions; Female; Humans; Male; Methyldopa; Middle Aged; Phenobarbital; Renin	1975
Enhancement of methyldopa metabolism with barbiturate. British medical journal, 1971, Aug-26, Volume: 3, Issue:5773 Topics: Catecholamines; Enzyme Induction; Epinephrine; Humans; Hypertension; Liver; Methyldopa; Microsomes, Liver; Norepinephrine; Phenobarbital	1971

Other Studies

34 other study(ies) available for phenobarbital and methyldopa

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Experimental spinal cord trauma, III: Therapeutic effect of immobilization and pharmacologic agents. Surgical neurology, 1978, Volume: 10, Issue:1 Topics: Animals; Dextrans; Haplorhini; Immobilization; Methyldopa; Phenobarbital; Phenoxybenzamine; Spinal Cord Injuries; Vasoconstrictor Agents	1978
Central action as a key to past and future therapy of hypertension. Progress in brain research, 1977, Volume: 47 Topics: Atropine; Brain; Humans; Hypertension; Methyldopa; Pargyline; Phenobarbital; Propranolol; Receptors, Adrenergic; Research Design	1977
Effect of alphamethyldopa and of phenobarbitone on angiotensin responsiveness and renin activity in man. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 11, Issue:1 Topics: Adolescent; Adult; Angiotensin II; Blood Pressure; Drug Interactions; Female; Humans; Male; Methyldopa; Middle Aged; Phenobarbital; Renin	1975
[Hemopoietic disorder caused by drugs--special significance placed on anemia]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Megaloblastic; Anemia, Sideroblastic; Chloramphenicol; Ethanol; Humans; Methotrexate; Methyldopa; Middle Aged; Neomycin; Penicillins; Phenacetin; Phenobarbital	1991
Maternal and perinatal outcome of conservative management of severe preeclampsia in midtrimester. American journal of obstetrics and gynecology, 1985, May-01, Volume: 152, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bed Rest; Birth Weight; Delivery, Obstetric; Diuretics; Female; Fetal Death; Gestational Age; Humans; Hydralazine; Infant, Newborn; Magnesium Sulfate; Methyldopa; Outcome and Process Assessment, Health Care; Phenobarbital; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Pregnancy, Prolonged; Retrospective Studies	1985
The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicology and applied pharmacology, 1985, Volume: 78, Issue:3 Topics: Administration, Oral; Animals; Atropine; Blood Glucose; Central Nervous System; Dieldrin; Drug Interactions; Gluconeogenesis; Hypoglycemia; Lethal Dose 50; Liver; Male; Methyldopa; Phenobarbital; Phosphoenolpyruvate Carboxykinase (GTP); Propranolol; Rats; Rats, Inbred Strains	1985
Psychiatric side effects of nonpsychiatric drugs. Seminars in psychiatry, 1971, Volume: 3, Issue:4 Topics: Aminophylline; Analgesics; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; Antihypertensive Agents; Central Nervous System Stimulants; Chlordiazepoxide; Diazepam; Diuretics; Drug-Related Side Effects and Adverse Reactions; Furosemide; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Insulin; Isoniazid; Mental Disorders; Methyldopa; Phenobarbital; Prednisone	1971
Antihypertensive drugs and depression. Psychological medicine, 1974, Volume: 4, Issue:4 Topics: Adult; Aged; Antihypertensive Agents; Bethanidine; Chlorthalidone; Depression; Diuretics; Drug Therapy, Combination; Fatigue; Furosemide; Guanethidine; Humans; Hydrochlorothiazide; Methyldopa; Middle Aged; Phenobarbital; Potassium; Pyrazines; Reserpine; Self-Assessment; Sodium Chloride Symporter Inhibitors; Theobromine	1974
Peripheral cardiovascular effects, in the pithed rat, of compounds used in the treatment of hypertension. British journal of pharmacology, 1972, Volume: 46, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cordotomy; Diazoxide; Electric Stimulation; Ergotamine; Guanethidine; Hydrochlorothiazide; Iproniazid; Male; Mecamylamine; Methyldopa; Pargyline; Phenobarbital; Rats; Reserpine; Sympathetic Nervous System; Thiocyanates; Trimethaphan	1972
Barbiturates and methyldopa metabolism. British medical journal, 1973, Jan-06, Volume: 1, Issue:5844 Topics: Drug Interactions; Humans; Methyldopa; Phenobarbital	1973
[The effect of alpha methyldopa and barbiturate on the bile secretion]. Orvosi hetilap, 1973, Apr-01, Volume: 114, Issue:13 Topics: Animals; Bile; Drug Synergism; Methyldopa; Phenobarbital; Rats; Secretory Rate	1973
[Pharmacological analysis of a case of postanoxic intention and action myoclonus]. Revue neurologique, 1971, Volume: 124, Issue:1 Topics: 5-Hydroxytryptophan; Alcohols; Anticonvulsants; Benzoates; Carbamazepine; Chlorpromazine; Diazepam; Dibenzazepines; Dopamine; Ergotamine; Female; Haloperidol; Humans; Hypoxia, Brain; Methotrimeprazine; Methyldopa; Methysergide; Middle Aged; Myoclonus; Norepinephrine; Phenobarbital; Pyrrolidines; Stereotaxic Techniques; Sulfonamides; Tranquilizing Agents; Trihexyphenidyl	1971
Preoperative management of patients with ruptured intracranial aneurysms. Journal of neurosurgery, 1972, Volume: 36, Issue:5 Topics: Adult; Aged; Aminocaproates; Antifibrinolytic Agents; Antihypertensive Agents; Blood Pressure; Carotid Artery Diseases; Cerebral Angiography; Cerebral Arterial Diseases; Cerebral Hemorrhage; Chlorothiazide; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Methyldopa; Middle Aged; Phenobarbital; Preoperative Care; Spinal Puncture; Subarachnoid Hemorrhage	1972
Methyldopa metabolism and barbiturates. British medical journal, 1972, May-20, Volume: 2, Issue:5811 Topics: Animals; Barbiturates; Bile; Drug Interactions; Female; Injections, Intraperitoneal; Methyldopa; Phenobarbital; Rats	1972
[Enhancing alphamethyldopa metabolism with barbiturates in man]. Orvosi hetilap, 1971, Nov-21, Volume: 112, Issue:47 Topics: Drug Synergism; Epinephrine; Humans; Methyldopa; Norepinephrine; Phenobarbital	1971
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea	1967
Drug-induced ulcer of the lip. The British journal of dermatology, 1967, Volume: 79, Issue:2 Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Carcinoma, Squamous Cell; Chlorpromazine; Diagnosis, Differential; Female; Humans; Hydrocortisone; Lip; Male; Methyldopa; Middle Aged; Mouth Diseases; Phenobarbital; Phenylbutazone; Ulcer	1967
Arteriosclerotic hypertension often misdiagnosed, overtreated. Geriatrics, 1967, Volume: 22, Issue:11 Topics: Arteriosclerosis; Humans; Hypertension; Methyldopa; Phenobarbital; Prognosis; Reserpine	1967
Influence of Avicel PH-301 on the compressibility of alpha-methyldopa and phenobarbitone in direct compression. Drug development and industrial pharmacy, 2000, Volume: 26, Issue:9 Topics: Anticonvulsants; Antihypertensive Agents; Cellulose; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Compressive Strength; Elasticity; Excipients; Friction; Hypnotics and Sedatives; Lubrication; Methyldopa; Phenobarbital; Stearic Acids; Tablets; Technology, Pharmaceutical	2000
Effect of alpha-methyldopa on pentoxyresorufin O-dealkylation in liver microsomes from rats treated with phenobarbital. Archives of biochemistry and biophysics, 2001, Aug-01, Volume: 392, Issue:1 Topics: Animals; Ascorbic Acid; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1 Inhibitors; Dopamine; Enzyme Inhibitors; Glutathione; Levodopa; Lipid Peroxidation; Male; Methyldopa; Microsomes, Liver; NADP; Oxazines; Phenobarbital; Rats; Rats, Wistar	2001
A CONTROLLED CLINICAL TRIAL OF ALPHA METHYL DOPA IN PARKINSONIAN TREMOR. Journal of neurology, neurosurgery, and psychiatry, 1963, Volume: 26 Topics: Depression; Depressive Disorder; Hypnotics and Sedatives; Methyldopa; Parasympatholytics; Parkinsonian Disorders; Phenobarbital; Placebos; Toxicology; Tremor	1963
METHYLDOPA IN TREATMENT OF SEVERE TOXAEMIA OF PREGNANCY. British medical journal, 1964, Mar-21, Volume: 1, Issue:5385 Topics: Albuminuria; Antihypertensive Agents; Chlorothiazide; Female; Fetal Death; Humans; Methyldopa; Phenobarbital; Pre-Eclampsia; Pregnancy; Prognosis; Selective Serotonin Reuptake Inhibitors; Serotonin	1964
HYPERTENSION AND ITS COMPLICATIONS. 2. Nursing times, 1964, Jun-26, Volume: 60 Topics: Amobarbital; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cold Temperature; Diuretics; Guanethidine; Humans; Hypertension; Kidney Function Tests; Mecamylamine; Methyldopa; Nursing; Obesity; Ophthalmoscopy; Pempidine; Phenobarbital; Physical Exertion; Reserpine; Therapeutics; Toxicology	1964
Centrally active nonhormonal hot flash therapies. The American journal of medicine, 2005, Dec-19, Volume: 118 Suppl 12B Topics: Amines; Antidepressive Agents; Antihypertensive Agents; Belladonna Alkaloids; Clonidine; Cyclohexanecarboxylic Acids; Drug Combinations; Ergotamines; Female; Gabapentin; gamma-Aminobutyric Acid; Hot Flashes; Humans; Menopause; Methyldopa; Methysergide; Phenobarbital	2005