phenobarbital has been researched along with methotrexate in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 11 (32.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bankala, R; Doss, HM; Kapavarapu, RK; Kulkarni, P; Kumar, JS; Mathew, JE; Medishetti, R; Mudgal, J; Pal, M; Parsa, KVL; Ramarao, EVVS; Rasool, M; Shenoy, GG; Sunke, R; Thirupataiah, B | 1 |
| Venho, VM | 1 |
| Basu, TK; Williams, DC | 1 |
| Alfon, J; Hoffman, A | 1 |
| Hirota, Y | 1 |
| Furue, H | 1 |
| Basu, TK; Raven, RW; Williams, DC | 1 |
| Quan, L; Riley, S; Rowe, J; Sadoff, L | 1 |
| Rubaltelli, FF | 1 |
| Gastol-Lewińska, L | 1 |
| Heischkeil, R | 1 |
| Albani, F; Baruzzi, A; Bollini, C; Bollini, P; Cacciari, L; Ida, N; Riva, R | 1 |
| Moran, RG; Siegel, SE | 1 |
| Evans, MA | 1 |
| Cermanová, J; Chládek, J; Chládková, J; Martínková, J; Sispera, L | 1 |
| Amaddeo, P; Barbaglio, A; Faldi, F; Fontana, S; Ghilardi, R; Pericotti, S | 1 |
| Halwachs, S; Honscha, W; Schäfer, I; Seibel, P | 1 |
| Halwachs, S; Honscha, W; Lakoma, C; Schäfer, I; Seibel, P | 1 |
| Halwachs, S; Honscha, W; Schaefer, I; Seibel, P | 1 |
3 review(s) available for phenobarbital and methotrexate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Drug interactions with anticancer agents].
Topics: Allopurinol; Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Interactions; Drug Therapy, Combination; Humans; Liver; Methotrexate; Neoplasms; Phenobarbital | 1985 |
Problems in the chemotherapy of cancer in the neonate.
Topics: Age Factors; Antineoplastic Agents, Phytogenic; Blood Proteins; Glomerular Filtration Rate; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Tubules; Methotrexate; Neoplasms; Phenobarbital | 1981 |
31 other study(ies) available for phenobarbital and methotrexate
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
InCl
Topics: Animals; Arthritis; Cyclic Nucleotide Phosphodiesterases, Type 4; Encephalomyelitis, Autoimmune, Experimental; Freund's Adjuvant; Indium; Indoles; Molecular Structure; Multiple Sclerosis; Oligodendrocyte-Myelin Glycoprotein; Phosphodiesterase 4 Inhibitors; Quinoxalines; Rats; Structure-Activity Relationship; Zebrafish; Zebrafish Proteins | 2019 |
Effect of methotrexate on drug absorption from the rat small intestine in situ and in vitro.
Topics: Animals; Female; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Isoniazid; Mecamylamine; Methotrexate; Phenobarbital; Quinidine; Rats; Sulfisoxazole; Time Factors | 1976 |
Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Body Weight; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Ethylmorphine-N-Demethylase; Liver; Male; Methotrexate; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Proteins; Rats | 1975 |
High-dose methotrexate does not affect the pharmacodynamics of phenobarbital hypnotic action but decreases the central nervous system (CNS) sensitivity to pentylenetetrazol-induced maximal seizures in rats.
Topics: Animals; Brain Chemistry; Central Nervous System; Chromatography, High Pressure Liquid; Glucose; Hypnotics and Sedatives; Infusions, Intravenous; Male; Methotrexate; Pentylenetetrazole; Phenobarbital; Postural Balance; Rats; Reflex; Seizures | 1992 |
[Hemopoietic disorder caused by drugs--special significance placed on anemia].
Topics: Adult; Aged; Aged, 80 and over; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Megaloblastic; Anemia, Sideroblastic; Chloramphenicol; Ethanol; Humans; Methotrexate; Methyldopa; Middle Aged; Neomycin; Penicillins; Phenacetin; Phenobarbital | 1991 |
Methotrexate and alopecia.
Topics: Alopecia; Animals; Drug Synergism; Liver; Male; Methotrexate; Phenobarbital; Rats | 1973 |
New endocrine observations in a male patient with choriocarcinoma.
Topics: Adult; Brain Neoplasms; Cerebrospinal Fluid Proteins; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dexamethasone; Diagnostic Errors; Estradiol; Humans; Hydrocortisone; Lung Neoplasms; Luteinizing Hormone; Male; Medroxyprogesterone; Methotrexate; Neoplasm Metastasis; Phenobarbital; Testosterone; Vincristine | 1974 |
The role of the hepatic organic anion binding proteins. An experimental investigation of the mechanism of action of phenobarbital and amethopterin.
Topics: Animals; Bilirubin; Carrier Proteins; Liver; Methotrexate; Phenobarbital; Rats | 1972 |
Evaluation of the toxicity and teratogenecity of drugs.
Topics: Abnormalities, Drug-Induced; Animals; Barbiturates; Chick Embryo; Gestational Age; Insulin; Methotrexate; Phenobarbital; Tolbutamide; Toxicology | 1973 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene | 1973 |
Decreased phenytoin level during antineoplastic therapy: a case report.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Drug Interactions; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Phenobarbital; Phenytoin; Seizures; Vinblastine | 1983 |
Effects of anticonvulsants and methotrexate on calcium disposition.
Topics: Animals; Anticonvulsants; Calcium; Calcium Radioisotopes; Folic Acid; Intestinal Absorption; Male; Methotrexate; Mice; Phenobarbital; Phenytoin | 1980 |
No effect of phenobarbital pretreatment of rats on methotrexate pharmacokinetics in the isolated liver perfused in a single-pass way.
Topics: Animals; Bile; Excitatory Amino Acid Antagonists; Folic Acid Antagonists; Liver; Male; Methotrexate; Oxygen Consumption; Phenobarbital; Rats; Rats, Wistar; Vascular Resistance | 2001 |
Male breast cancer with mandibular metastasis. A case report.
Topics: Aged; Androstadienes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Cortisone; Cyclophosphamide; Diphosphonates; Docetaxel; Fatal Outcome; Fluorouracil; Furosemide; Humans; Imidazoles; Liver Neoplasms; Male; Mandibular Neoplasms; Mastectomy, Modified Radical; Methotrexate; Omeprazole; Osteolysis; Phenobarbital; Taxoids; Toremifene; Vinblastine; Vinorelbine; Zoledronic Acid | 2007 |
Antiepileptic drugs reduce efficacy of methotrexate chemotherapy by downregulation of Reduced folate carrier transport activity.
Topics: Animals; Anticonvulsants; Biological Transport; Cell Line, Tumor; Constitutive Androstane Receptor; Down-Regulation; Drug Antagonism; Folic Acid Antagonists; Membrane Transport Proteins; Methotrexate; Phenobarbital; Protein Kinase C; Rats; Receptors, Cytoplasmic and Nuclear; Reduced Folate Carrier Protein; Transcription Factors | 2009 |
The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier.
Topics: Animals; Anticonvulsants; Biological Transport; Carbamazepine; Cell Line, Transformed; Choroid Plexus; Down-Regulation; Male; Methotrexate; Phenobarbital; Rats; Rats, Sprague-Dawley; Reduced Folate Carrier Protein | 2011 |
Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway.
Topics: Animals; Anticonvulsants; Antimetabolites, Antineoplastic; Biosynthetic Pathways; Cell Line; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Drug Interactions; Half-Life; Methotrexate; Phenobarbital; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C; Pyridines; Rats; Receptors, Cytoplasmic and Nuclear; Reduced Folate Carrier Protein; Replication Protein C; Repressor Proteins; Ubiquitin | 2011 |