Compounds > phenobarbital

phenobarbital and lovastatin

phenobarbital has been researched along with lovastatin in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (38.89)	18.2507
2000's	5 (27.78)	29.6817
2010's	6 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kliewer, SA; Lehmann, JM; McKee, DD; Moore, JT; Watson, MA; Willson, TM	1
Topliss, JG; Yoshida, F	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW	1
Kari, PH; Lu, AY; Vyas, KP; Wang, RW	1
Kari, PH; Pitzenberger, SM; Vyas, KP	1
Andersson, M; Appelkvist, EL; Chojnacki, T; Dallner, G; Ericsson, J; Schedin, S	1
Guzelian, PS; Kocarek, TA; Schuetz, EG	1
Serizawa, N; Watanabe, I	1
Cao, CX; Fan, LY; Li, M; Sun, J; Zhang, W	1

Reviews

1 review(s) available for phenobarbital and lovastatin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

17 other study(ies) available for phenobarbital and lovastatin

Article	Year
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. The Journal of clinical investigation, 1998, Sep-01, Volume: 102, Issue:5 Topics: Amino Acid Sequence; Base Sequence; Cell Line; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Enzyme Activation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Genes, Reporter; Histone Acetyltransferases; Humans; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Structure; Nuclear Receptor Coactivator 1; Pharmaceutical Preparations; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transcription Factors; Transfection	1998
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. Toxicologic pathology, 1991, Volume: 19, Issue:3 Topics: Adenoma; Animals; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Liver; Lovastatin; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Simvastatin; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Time Factors	1991
Biotransformation of lovastatin--III. Effect of cimetidine and famotidine on in vitro metabolism of lovastatin by rat and human liver microsomes. Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1 Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Female; Humans; Lovastatin; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1990
Regioselectivity and stereoselectivity in the metabolism of HMG-CoA reductase inhibitors. Biochemical and biophysical research communications, 1990, Feb-14, Volume: 166, Issue:3 Topics: Animals; Anticholesteremic Agents; Biotransformation; Chromatography, High Pressure Liquid; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Simvastatin; Spectrophotometry, Ultraviolet; Structure-Activity Relationship	1990
Modulations in hepatic branch-point enzymes involved in isoprenoid biosynthesis upon dietary and drug treatments of rats. Biochimica et biophysica acta, 1994, Aug-25, Volume: 1214, Issue:1 Topics: Animals; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cytosol; Diet; Dimethylallyltranstransferase; Dolichols; Farnesyl-Diphosphate Farnesyltransferase; Liver; Lovastatin; Male; Microbodies; Microsomes, Liver; Phenobarbital; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley	1994
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. Toxicology and applied pharmacology, 1993, Volume: 120, Issue:2 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Fibric Acids; Hydroxycholesterols; Hypolipidemic Agents; L-Lactate Dehydrogenase; Liver; Lovastatin; Male; Mevalonic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger	1993
Molecular approaches for production of pravastatin, a HMG-CoA reductase inhibitor: transcriptional regulation of the cytochrome p450sca gene from Streptomyces carbophilus by ML-236B sodium salt and phenobarbital. Gene, 1998, Mar-27, Volume: 210, Issue:1 Topics: Amino Acid Sequence; Anticholesteremic Agents; Antifungal Agents; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mixed Function Oxygenases; Molecular Sequence Data; Phenobarbital; Pravastatin; Repressor Proteins; RNA, Messenger; Sequence Analysis, DNA; Streptomyces; Up-Regulation	1998
Quantitative analysis of lovastatin in capsule of Chinese medicine monascus by capillary zone electrophoresis with UV-vis detector. Journal of pharmaceutical and biomedical analysis, 2007, Jan-04, Volume: 43, Issue:1 Topics: Buffers; Capsules; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indicators and Reagents; Lovastatin; Monascus; Phenobarbital; Reference Standards; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet	2007