phenobarbital has been researched along with isomethyleugenol in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (82.76) | 18.7374 |
| 1990's | 14 (16.09) | 18.2507 |
| 2000's | 1 (1.15) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Canonne, MA; Hue, G; Landriau, N; Maitrot, B; Rocher, A | 1 |
| Beyer, KH; Hilderbrandt, AG; Sadée, W; Schwandt, HJ | 1 |
| Matthiesen, U | 1 |
| Joly, JG; Mavier, P; Villeneuve, JP | 1 |
| Faure, J; Feuerstein, C; Gavend, M; Vincent, F | 1 |
| Kurata, K; Takeuchi, M; Yoshida, K | 1 |
| Kido, H; Kurata, K; Takeuchi, M; Yamaguchi, N | 1 |
| Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH | 1 |
| Johnson, GF; Least, CJ; Solomon, HM | 1 |
| Callery, PS; Leslie, J | 1 |
| Ayers, GJ; Burnett, D; Goudie, JH; Reed, K | 1 |
| Bius, DL; Boyles, LW; Dudley, KH; Kraus, BL | 1 |
| Kelly, RC; Sunshine, I; Valentour, JC | 1 |
| Duceman, BW; Leonard, TB; Liu, DK; Smith, SJ; Vesell, ES | 1 |
| Friel, P; Troupin, AS | 1 |
| Bailey, DG; Davis, HL; Falk, KJ | 1 |
| Gupta, RN; Keane, PM | 1 |
| Acheampont-Mensah, D; Feuer, G | 1 |
| Biemann, K; Costello, CE; Wong, LK | 1 |
| De Biasi, A; Keizer, J; Sbraccia, M; Testai, E; Vittozzi, L | 1 |
| Bruce, I; Hooper, WD; Reilly, PE | 1 |
| Goodman, JI; Vorce, RL | 1 |
| Zhao, QZ | 1 |
| Barrass, NC; Evans, JG; Phillimore, HE; Rumsby, PC | 1 |
| Koda, A; Konishi, Y; Mori, Y; Nagai, H; Toyoshi, K; Yamazaki, H | 1 |
| Gerstner, E; Grotjahn, H; Heubel, F | 1 |
| Berggren, M; Ericsson, JL; Rane, A; Yaffe, S | 1 |
| Bickel, MH; Willi, P | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Estabrook, RW; Franklin, MR; Hildebrandt, AG | 1 |
| Kyogoku, Y; Yu, BS | 1 |
| Hildebrandt, AG | 1 |
| Carroll, FI; Freudenthal, RI | 1 |
| Bolt, HM; Kappus, H; Remmer, H | 1 |
| Burnett, D; Goudie, JH | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G; Miller, DR | 1 |
| Rodgers, G; Roger, JC; Soo, A | 1 |
| Cremers, HM; Verheesen, PE | 1 |
| Acheampong-Mensah, D; Feuer, G | 1 |
| Wu, A | 1 |
| Flynn, EJ; Spector, S | 1 |
| Metaxas, JM; Solow, EB; Summers, TR | 1 |
| Duceman, B; Jacob, ST; Liu, DK; Smith, SJ; Vesell, ES | 1 |
| Kato, R; Shoji, H; Takanaka, A | 1 |
| Moslen, MT; Ree, HJ; Reynolds, ES | 1 |
| Boucher, EA; Horning, EC; Horning, MG; Stafford, M | 1 |
| Andersgaard, HA; Pederson, AO | 1 |
| Horie, T; Kitada, M; Kitagawa, H | 1 |
| Knabe, J; Strauss, D | 1 |
| Fuller, GC; Lal, H; Louis-Ferdinand, RT | 1 |
| Barnes, JR; Ranta, KE | 1 |
| von Bahr, C | 1 |
| Fiereck, EA; Tietz, NW | 1 |
| Horning, EC; Horning, MG | 1 |
| Boobis, AR; Gillespie, JS; Pollock, D | 1 |
| Banks, GS; Lundeen, PB; Ruddon, RW | 1 |
| Bhatnagar, SP | 1 |
| Donahue, JD; Johnson, RK; Jondorf, WR | 1 |
| Aebi, H; Baggiolini, M; Dewald, B | 1 |
| Dehn, F; LeValley, SE; Lombrozo, L; Mitoma, C | 1 |
| Kupferberg, HJ | 1 |
| Nakazawa, K | 1 |
| Fanelli, R; Garattini, S; Marcucci, F; Mussini, E | 1 |
| Henderson, PT; Kersten, KJ | 1 |
| Capelle, N; Fournier, E; Kaloyanova, F; Treich, I | 1 |
| Benakis, A; Glasson, B; Strolin-Benedetti, M | 1 |
| Fuller, GC; Lal, H; Olshan, AM | 1 |
| Netter, KJ; Pomp, H; Schnoor, M | 1 |
| Spoerlein, MT; VanderWende, C | 1 |
| Farber, E; Ghoshal, AK | 1 |
| Buchet, JP; Geubel, A; Lauwerys, R; Mahieu, P; Pauwels, S | 1 |
| Mostafa, MH; Ruchirawat, M; Weisburger, EK | 1 |
| Kasuya, Y; Kawanishi, T; Nakadate, M; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A | 1 |
| Brazier, JL; Desage, M; Renaud, H; Ribon, B; Salle, B | 1 |
| Brügmann, G | 1 |
| Axelrod, J; Meeks, RG; Sastry, BV; Statham, CN | 1 |
| Goodman, JI; Harbison, ML; McClain, RM; Ray, JS | 1 |
| Hanzlik, RP; Riley, P | 1 |
| Ariyoshi, N; Oguri, K; Yoshimura, H | 1 |
| Constantino, L; Iley, J | 1 |
| Conney, AH; Gut, I | 1 |
| Baker, MT; Chadam, MV; Ronnenberg, WC | 1 |
| Counts, JL; Downing, JC; Goodman, JL; Harbison, ML; McClain, RM; Sarmiento, JI | 1 |
| Kishimoto, D; Kurihara, N; Masuda, M | 1 |
| Allen, PT; Poirier, LA | 1 |
| Boyle, SP; Craft, JA | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 1 |
2 review(s) available for phenobarbital and isomethyleugenol
| Article | Year |
|---|---|
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.
Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Ethylamines; Hydrogen-Ion Concentration; In Vitro Techniques; Isocitrate Dehydrogenase; Methylation; Metyrapone; Microsomes, Liver; Morphinans; Oxidation-Reduction; Phenobarbital; Proadifen; Pseudomonas; Rats; Spectrum Analysis | 1972 |
Metabolism of certain commonly used barbiturates.
Topics: Alcohols; Amobarbital; Animals; Barbiturates; Biotransformation; Chemical Phenomena; Chemistry; Dealkylation; Dogs; Ethers, Cyclic; Humans; Hydroxylation; Kinetics; Mephobarbital; Methylation; Microsomes, Liver; Oxidation-Reduction; Pentobarbital; Phenobarbital; Stereoisomerism | 1973 |
85 other study(ies) available for phenobarbital and isomethyleugenol
| Article | Year |
|---|---|
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylation; Phenobarbital; Phenytoin; Solvents; Temperature | 1976 |
Effects of enzyme induction and inhibition on microsomal oxidation of 1,4-benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Hydroxylation; Male; Medazepam; Methylation; Metyrapone; Microsomes, Liver; Phenobarbital; Rats | 1976 |
[Simple identification of barbiturates after methylation with DMF-DMA by capillary gas chromatography and mass spectrometry].
Topics: Acetals; Amobarbital; Barbiturates; Chromatography, Gas; Dimethylformamide; Mass Spectrometry; Methylation; Phenobarbital | 1979 |
Chronic ethanol administration induces a form of cytochrome P-450 with specific spectral and catalytic properties.
Topics: Aniline Compounds; Animals; Catalysis; Cytochrome P-450 Enzyme System; Ethanol; Female; Hydroxylation; Kinetics; Methylation; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1977 |
Routine identification and determination of 11 barbiturates in biological samples.
Topics: Barbiturates; Chromatography, Gas; Humans; Methylation; Pentobarbital; Phenobarbital; Secobarbital | 1979 |
Quantitative flash-methylation analysis of phenobarbital.
Topics: Chromatography, Gas; Mass Spectrometry; Methods; Methylation; Molecular Weight; Phenobarbital | 1979 |
Quantitative flash-methylation analysis of phenobarbital.
Topics: Chromatography, Gas; Methylation; Phenobarbital | 1979 |
Preliminary observations on the pharmacokinetics of methylphenobarbitone.
Topics: Adult; Drug Combinations; Female; Humans; Kinetics; Male; Mephobarbital; Metabolic Clearance Rate; Methylation; Middle Aged; Phenobarbital; Regression Analysis | 1978 |
Micro-scale anticonvulsant assay with use of nitrogen/phosphorus detector and on-column methylation compared with a macro-scale procedure involving flame-ionization detection.
Topics: Anticonvulsants; Chromatography, Gas; Flame Ionization; Humans; Methylation; Phenobarbital; Phenytoin; Primidone | 1977 |
Thermal decomposition of 1,3-dimethyl derivative of phenobarbital in trimethylanilinium hydroxide.
Topics: Aniline Compounds; Chromatography, Gas; Drug Stability; Hot Temperature; Mass Spectrometry; Methylation; Phenobarbital | 1977 |
Quality control in the simultaneous assay of anticonvulsants using an automated gas chromatographic system with a nitrogen detector.
Topics: Anticonvulsants; Chromatography, Gas; Humans; Methylation; Nitrogen; Phenobarbital; Phenytoin; Primidone; Quality Control | 1977 |
Gas chromatographic on-column methylation technique for the simulataneous determination of antiepileptic drugs in blood.
Topics: Anticonvulsants; Chromatography, Gas; Ethosuximide; Methylation; Phenobarbital; Phenytoin; Primidone | 1977 |
Solvent suppression of the decomposition of phenobarbital during on-column methylation with trimethylanilinium hydroxide.
Topics: Aniline Compounds; Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Indicators and Reagents; Methylation; Phenobarbital | 1977 |
Phenobarbital-induced increases in methylation of ribosomal precursor ribonucleic acid.
Topics: Animals; Cell Nucleolus; DNA; In Vitro Techniques; Liver; Male; Methylation; Methyltransferases; Microsomes, Liver; Orotic Acid; Phenobarbital; Rats; Ribosomes; RNA; Stimulation, Chemical | 1976 |
Flash-heater ethylation of some antiepileptic drugs.
Topics: Alkylation; Anticonvulsants; Evaluation Studies as Topic; Hot Temperature; Humans; Mephenytoin; Mephobarbital; Methylation; Phenobarbital; Phenytoin; Primidone; Saliva | 1975 |
Improved method for the simultaneous determination of phenobarbital, primidone and diphenylhydantoin in patient's serum by gas-liquid chromatography.
Topics: Anticonvulsants; Chromatography, Gas; Drug Stability; Humans; Methods; Methylation; Phenobarbital; Phenytoin; Primidone | 1975 |
Letter: Precolumn methylation of phenobarbital with trimethylanilinium hydroxide.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Indicators and Reagents; Methods; Methylation; Phenobarbital | 1975 |
Effect of phenobarbital on methyl transfer between methylated drugs and hepatic microsomal phospholipids.
Topics: Animals; Formaldehyde; In Vitro Techniques; Male; Methionine; Methylation; Microsomes, Liver; Nicotine; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Rats | 1975 |
Methylation artifacts in the gas chromatography of serum extracts. Competitive suppression with trimethyl-d9 anilinium hydroxide.
Topics: Aniline Compounds; Chromatography, Gas; Indicators and Reagents; Mass Spectrometry; Methylation; Phenobarbital; Phenytoin; Phosphatidylcholines; Quaternary Ammonium Compounds | 1976 |
The regioselective binding of CHCl3 reactive intermediates to microsomal phospholipids.
Topics: Animals; Biotransformation; Carbon Radioisotopes; Cell Hypoxia; Chloroform; Drug Synergism; Hydrolysis; Kinetics; Male; Methylation; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Sprague-Dawley | 1992 |
Comparative metabolism of clinically important precursors of N-desmethyldiazepam using phenobarbitone-pretreated rat liver microsomes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Hydroxylation; Male; Methylation; Microsomes, Liver; Nordazepam; Phenobarbital; Prazepam; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1992 |
Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Carcinoma, Hepatocellular; Chloroform; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylation; Mice; Phenobarbital; Restriction Mapping; Rodent Diseases | 1991 |
[The expression of alpha 1-inhibitor 3 gene and some changes of its structure in rat hepatomas].
Topics: Acute-Phase Proteins; Animals; Diethylnitrosamine; DNA Transposable Elements; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Methylation; Phenobarbital; Polymorphism, Restriction Fragment Length; Protease Inhibitors; Rats; Rats, Inbred Strains | 1991 |
Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Blotting, Southern; Codon; Diethylnitrosamine; DNA; Gene Expression; Genes, ras; Immunoblotting; Liver Neoplasms, Experimental; Methylation; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Phenobarbital; RNA, Neoplasm | 1991 |
A comparative study of the mutagenic activation of N-nitrosopropylamines by various animal species and man: evidence for a cytochrome P-450 dependent reaction.
Topics: Adult; Aniline Hydroxylase; Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; DNA; Dose-Response Relationship, Drug; Female; Humans; Liver; Macaca fascicularis; Macaca mulatta; Male; Mesocricetus; Methylation; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred Strains; Mutagens; Nitrosamines; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
Dichloro-p-nitroanisole (DPNA)-demethylation not specifically induced by phenobarbitone in mice.
Topics: Animals; Anisoles; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Male; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Oxidative drug metabolism in the perinatal rabbit liver and placenta. A biochemical and morphologic study.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzopyrenes; Cytochrome Reductases; Electron Transport; Endoplasmic Reticulum; Female; Gestational Age; Hydroxylation; Liver; Methylation; Microscopy, Electron; Microsomes; Microsomes, Liver; NAD; NADP; Phenobarbital; Placenta; Pregnancy; Rabbits; Species Specificity | 1973 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.
Topics: Acetates; Aniline Compounds; Animals; Calcium; Depression, Chemical; Edetic Acid; Formaldehyde; Glycols; Kinetics; Magnesium; Male; Methylation; Microsomes, Liver; NADP; Niacinamide; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Species Specificity; Stimulation, Chemical; Sulfhydryl Reagents; Swine | 1973 |
Drug metabolism by hepatic microsomes from phenobarbital-treated or starved male and female rats in the presence of inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Female; Hexobarbital; Liver; Male; Methylation; Microsomes, Liver; Morphinans; Niacinamide; Organ Size; Phenobarbital; Proadifen; Rats; Starvation | 1971 |
Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450-catalyzed mixed function oxidation reactions.
Topics: Animals; Anisoles; Binding Sites; Carbon Monoxide; Cytochromes; Electron Transport; Electron Transport Complex IV; In Vitro Techniques; Methylation; Metyrapone; Microsomes, Liver; Morphine; Nitroso Compounds; Oxidation-Reduction; Phenobarbital; Rats | 1970 |
Selective binding of barbital to the adenine moieties of FAD and NAD.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Barbiturates; Chemical Phenomena; Chemistry; Deuterium; Dimethyl Sulfoxide; Flavin-Adenine Dinucleotide; Fluorometry; Infrared Rays; Magnetic Resonance Spectroscopy; Methylation; Models, Chemical; NAD; Optical Rotatory Dispersion; Phenobarbital; Spectrophotometry; Ultraviolet Rays | 1970 |
Demethylation of mestranol to ethinyloestradiol in vitro and in vivo.
Topics: Animals; Body Water; Carbon Isotopes; Chromatography; DDT; Ethinyl Estradiol; Female; Hydrogenation; In Vitro Techniques; Male; Mestranol; Methods; Methylation; Microsomes, Liver; Phenobarbital; Rats; Spirometry; Time Factors; Tritium | 1972 |
A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector.
Topics: Chromatography, Gas; Electrodes; Humans; Indicators and Reagents; Methods; Methylation; Nitrogen; Phenobarbital; Phenytoin; Primidone | 1973 |
The influence of methyl groups on toxicity and drug metabolism.
Topics: Administration, Oral; Amphetamine; Animals; Carbon Isotopes; Coumarins; Enzyme Induction; Female; Humans; Mephobarbital; Methylation; Microscopy, Electron; Microsomes, Liver; Nicotine; Phenobarbital; Phenols; Phospholipids; Pyrazoles; Rats; Structure-Activity Relationship; Tritium | 1973 |
Simultaneous determination of carbamazapine ("Tegretol") and other anticonvulsants in human plasma by gas-liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Computers; Dibenzazepines; Humans; Hydantoins; Mephobarbital; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Quaternary Ammonium Compounds | 1973 |
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Humans; Mephobarbital; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Succinimides; Temperature; Time Factors; Trimethadione | 1973 |
Relation between the hepatic action of drugs and the synthesis of subcellular structures.
Topics: Aminopyrine N-Demethylase; Analysis of Variance; Animals; Choline; Dactinomycin; Deficiency Diseases; Diet; Drug Interactions; In Vitro Techniques; Liver; Male; Methionine; Methylation; Methyltransferases; Microsomes, Liver; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Protein Biosynthesis; Rats; S-Adenosylmethionine; Subcellular Fractions | 1974 |
Letter: Concerning on-column methylation of phenobarbital.
Topics: Chromatography, Gas; Humans; Mass Spectrometry; Methylation; Phenobarbital | 1974 |
Radioimmunoassay for hepatic N-demethylation of metharbital in vitro.
Topics: Animals; Antibodies; Barbiturates; In Vitro Techniques; Liver; Male; Methods; Methylation; Mice; Phenobarbital; Rabbits; Radioimmunoassay; Time Factors; Tritium | 1974 |
Antiepileptic drugs: a current assessment of simultaneous determination of multiple drug therapy by gas liquid chromatography-on column methylation.
Topics: Adult; Anticonvulsants; Autoanalysis; Barbiturates; Buffers; Child; Chromatography, Gas; Humans; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Solvents; Temperature | 1974 |
Further studies on post-transcriptional stabilization of ribosomal precursor ribonucleic acid by phenobarbital.
Topics: Animals; Carbon Radioisotopes; Cell Nucleolus; Cell Nucleus; DNA; DNA-Directed RNA Polymerases; In Vitro Techniques; Isotope Labeling; Liver; Male; Methionine; Methylation; Phenobarbital; Proteins; Rats; Ribonucleases; RNA; RNA, Ribosomal; Time Factors; Transcription, Genetic; Tritium | 1974 |
Metabolism of carcinogenic compounds. I. Effect of phenobarbital and methylcholanthrene on the activities of N-demethylation of carcinogenic compounds by liver microsomes of male and female rats.
Topics: Amines; Animals; Carcinogens; Female; Liver; Male; Methylation; Methylcholanthrene; Microsomes; Nitrosamines; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1967 |
Liver parenchymal cell injury. IX. Phenobarbital potentiation of endoplasmic reticulum denaturation following carbon tetrachloride.
Topics: Animals; Autoradiography; Calcium; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochromes; Cytoplasmic Granules; Endoplasmic Reticulum; Glucosephosphate Dehydrogenase; Liver; Male; Methylation; Microscopy, Electron; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; RNA; Time Factors; Zinc | 1972 |
A rapid procedure for the isolation of drugs and drug metabolites from plasma.
Topics: 1-Propanol; Animals; Caffeine; Carbon Isotopes; Carbonates; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids; Humans; Mass Spectrometry; Methods; Methylation; Phenobarbital; Potassium; Rats; Silicon | 1972 |
Determination of non-N-methylated barbiturates in suppositories.
Topics: Barbiturates; Drug Stability; Hydrogen-Ion Concentration; Kinetics; Methods; Methylation; Phenobarbital; Solubility; Spectrophotometry; Suppositories | 1972 |
Studies on drug metabolism. 13. Possible role of liver microsomal cytochrome P-450 in the oxidative N-demethylation of p-substituted dimethylaniline, N-methyl-N-alkylaniline and N-methyl-N-acylaniline derivatives.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Male; Methylation; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1972 |
[Synthesis of optically active N-methylbarbiturates. 12. Barbituric acid derivatives].
Topics: Acetates; Barbiturates; Codeine; Cyanides; Hexobarbital; Methylation; Optical Rotation; Phenobarbital; Quinine | 1972 |
Amphetamine inhibition of hepatic drug metabolism: evidence for a competitive mechanism.
Topics: Amphetamine; Aniline Compounds; Animals; Binding, Competitive; Dextroamphetamine; Enzyme Induction; Female; Kinetics; Liver; Male; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1972 |
The metabolism of dimethylformamide and dimethylacetamide.
Topics: Acetamides; Animals; Antipyrine; Chromatography, Gas; Chromatography, Thin Layer; Dimethylformamide; Enzyme Induction; In Vitro Techniques; Liver; Male; Mass Spectrometry; Methylation; Phenobarbital; Rats; Spectrophotometry, Infrared | 1972 |
Binding and oxidation of amitriptyline and a series of its oxidized metabolites in liver microsomes from untreated and phenobarbital-treated rats.
Topics: Amitriptyline; Animals; Chromatography, Gas; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Male; Mass Spectrometry; Methylation; Microsomes, Liver; Nortriptyline; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Stimulation, Chemical; Structure-Activity Relationship; Time Factors | 1972 |
A gas-chromatographic method for separating and measuring barbiturates and glutethimide in blood.
Topics: Amobarbital; Barbiturates; Blood Chemical Analysis; Chloroform; Chromatography, Gas; Evaluation Studies as Topic; Glass; Glutethimide; Hexobarbital; Humans; Hydrogen-Ion Concentration; Mathematics; Mephobarbital; Methods; Methohexital; Methylation; Pentobarbital; Phenobarbital; Secobarbital; Solubility; Spectrophotometry; Time Factors; Ultraviolet Rays | 1971 |
Metabolic profiles: gas-phase methods for analysis of metabolites.
Topics: Acids; Animals; Benzyl Compounds; Carboxylic Acids; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Ion Exchange; Computers; Female; Glucuronates; Hippurates; Humans; Hydroxylamines; Infant, Newborn; Ketosteroids; Lactones; Male; Mass Spectrometry; Metabolism; Methylation; Pharmaceutical Preparations; Phenobarbital; Phenylacetates; Rats; Sex Factors; Steroids; Sterols | 1971 |
Influence of phenobarbitone on liver regeneration and microsomal N-demethylating activity in partially hepatectomized rats.
Topics: Animals; Hepatectomy; Liver; Liver Regeneration; Male; Methylation; Microsomes, Liver; Mitosis; Organ Size; Phenobarbital; Rats | 1971 |
Effects of the carcinogen methylazoxymethanol acetate on protein synthesis and drug metaboliism in rat livers.
Topics: Animals; Azo Compounds; Carcinogens; Dose-Response Relationship, Drug; Enzyme Induction; In Vitro Techniques; Leucine; Liver; Male; Methanol; Methylation; Methyltransferases; Microsomes, Liver; Morphinans; Nitrosamines; Pharmaceutical Preparations; Phenobarbital; Polyribosomes; Protein Biosynthesis; Rats; Time Factors; Tritium | 1971 |
The metabolism of chlorpromazine by developing rabbit liver.
Topics: Age Factors; Animals; Animals, Newborn; Biotransformation; Chlorpromazine; Chromatography, Thin Layer; Drug Interactions; Ethionine; Humans; Hydroxylation; In Vitro Techniques; Infant, Newborn; Liver; Methylation; Microsomes, Liver; Morphine; Perfusion; Phenobarbital; Rabbits; Stimulation, Chemical; Sulfides; Sulfoxides; Time Factors | 1971 |
Studies with N-methyl emetine.
Topics: Alkaloids; Animals; Carbon Isotopes; Depression, Chemical; Emetine; Female; Hexobarbital; In Vitro Techniques; Leucine; Methylation; Microsomes, Liver; Phenobarbital; Phenylalanine; Protein Biosynthesis; Rats; Stimulation, Chemical | 1969 |
N-demethylation of p-(N1-methylhydrazion methyl)-N-isopropyl benzamide (procarbazine), a cytostatically active methylhydrazine derivative, in the intact rat and in the isolated perfused rat liver.
Topics: Animals; Benzoates; Carbon Dioxide; Carbon Isotopes; Hydrazines; Liver; Male; Methylation; Methylcholanthrene; Oxidation-Reduction; Perfusion; Phenobarbital; Proadifen; Rats | 1969 |
Nature of the effect of caffeine on the drug-metabolizing enzymes.
Topics: 17-Hydroxycorticosteroids; Acetanilides; Amino Acids; Aminopyrine; Aniline Compounds; Animals; Caffeine; Cytochromes; Dactinomycin; Drug Antagonism; Enzyme Induction; Female; Humans; Male; Methylation; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnanes; Pyridones; Rats; Stimulation, Chemical; Time Factors; Zoxazolamine | 1969 |
Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.
Topics: Aniline Compounds; Chromatography, Gas; Hot Temperature; Humans; Methods; Methylation; Phenobarbital; Phenytoin; Primidone | 1970 |
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chlorides; Chromatography, Paper; Dealkylation; Desipramine; Ethylamines; Imipramine; Liver; Magnesium; Male; Metabolism; Methylation; Oxidation-Reduction; Oxides; Phenobarbital; Proadifen; Rats; Valerates | 1970 |
Effect of phenobarbital on the in vitro metabolism of diazepam in several animal species.
Topics: Animals; Chromatography, Gas; Dealkylation; Diazepam; Fasting; Guinea Pigs; Male; Metabolism; Methylation; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxazepam; Phenobarbital; Rats; Species Specificity | 1970 |
Metabolism of drugs during rat liver regeneration.
Topics: Aminopyrine; Aniline Compounds; Animals; Dealkylation; DNA; Glucuronates; Hepatectomy; Hexosyltransferases; Hydroxylation; Laparotomy; Liver; Liver Regeneration; Male; Methylation; Microsomes, Liver; Mitosis; Mixed Function Oxygenases; Nitrophenols; Nucleoside Diphosphate Sugars; Organ Size; Oxidoreductases; Phenobarbital; Rats; Stimulation, Chemical; Time Factors; Uracil Nucleotides | 1970 |
[Application of gas chromatography to the identification and determination of barbiturate derivatives in the blood during acute poisoning].
Topics: Amobarbital; Barbiturates; Chemistry, Clinical; Chromatography, Gas; Coma; Humans; Methods; Methylation; Pentobarbital; Phenobarbital; Secobarbital | 1970 |
[Various problems on drug catabolism using labelled molecules].
Topics: Animals; Carbon Dioxide; Chromatography, Gas; Humans; Kidney Diseases; Methylation; Pharmaceutical Preparations; Phenobarbital; Radioisotopes; Respiratory System | 1968 |
The stimulatory effect of phenobarbital on the N-demethylation of P-chloro-N-methylaniline.
Topics: Aminopyrine; Aniline Compounds; Animals; Enzyme Induction; Female; Formaldehyde; Liver; Male; Methods; Methylation; Microsomes; Phenobarbital; Rats | 1969 |
[Studies on drug demethylation in fetal liver].
Topics: Aniline Compounds; Female; Fetus; Humans; Liver; Maternal-Fetal Exchange; Methylation; Microsomes; Organ Size; Phenobarbital; Pregnancy | 1969 |
Nature of the tremors induced by p-methoxydopamine.
Topics: Animals; Chlorpromazine; Dopamine; Male; Methylation; Mice; Movement; Parasympatholytics; Phenobarbital; Propranolol; Tremor | 1967 |
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens.
Topics: Animals; Choline Deficiency; DNA; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Phenobarbital; Rats; Rats, Inbred F344 | 1984 |
The influence of liver disease on the methylation of arsenite in humans.
Topics: Adult; Aminopyrine; Arsenic; Arsenicals; Arsenites; Female; Humans; Liver Diseases; Liver Function Tests; Male; Methylation; Middle Aged; Phenobarbital | 1984 |
Effects of various microsomal enzyme inducers on M-demethylation of chlorpromazine.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Chlorpromazine; Male; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pharmacology; Phenobarbital; Rats | 1983 |
Effect of phenobarbital and 3-methylcholanthrene on the hepatic microsomal metabolism of N-nitrosodimethylamine, N-nitrosomethylbutylamine and N-nitrosomethylbenzylamine.
Topics: Animals; Chromatography, Gas; Dimethylnitrosamine; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
In vivo N7 methylation of theophylline to caffeine in premature infants. Studies with use of stable isotopes.
Topics: Caffeine; Carbon Isotopes; Humans; Infant, Newborn; Infant, Premature; Methylation; Nitrogen Isotopes; Phenobarbital; Theophylline; Time Factors | 1981 |
[Gas chromatographic determination of phenytoin, phenobarbital and primidone: flash-methylation after direct addition of trimethyl-phenyl-ammonium hydroxide to the ethyl acetate extract (author's transl)].
Topics: Aniline Compounds; Chromatography, Gas; Humans; Methylation; Phenobarbital; Phenytoin; Primidone; Quaternary Ammonium Compounds | 1981 |
Changes in phospholipid methyltransferases and membrane microviscosity during induction of rat liver microsomal cytochrome P-450 by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cell Membrane; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylation; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; S-Adenosylmethionine; Temperature; Tritium; Viscosity | 1981 |
Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Cell Division; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms; Male; Methylation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Oncogenes; Phenobarbital; Polymorphism, Restriction Fragment Length; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; RNA, Messenger | 1994 |
Electron transfer in P450 mechanisms. Microsomal metabolism of cyclopropylbenzene and p-cyclopropylanisole.
Topics: Animals; Anisoles; Benzene Derivatives; Benzoates; Benzoic Acid; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Hydroxylation; Isoenzymes; Kinetics; Methylation; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1994 |
Identification of in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl from phenobarbital-treated dog liver microsomes.
Topics: Animals; Chromatography, Gas; Dogs; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Methylation; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls | 1993 |
The microsomal dealkylation of N,N-dialkylbenzamides.
Topics: Alkylation; Amidohydrolases; Animals; Benzamides; Benzoates; Benzoic Acid; Cytochrome P-450 Enzyme System; Kinetics; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Substrate Specificity | 1994 |
Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Ethanol; Male; Methylamines; Methylation; Methylcholanthrene; Microsomes, Liver; Oxygen; Oxygenases; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Inhibitory effects of propofol on cytochrome P450 activities in rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enflurane; Hydroxylation; Isoniazid; Male; Methylation; Microsomes, Liver; Phenobarbital; Propofol; Rats; Rats, Sprague-Dawley; Toluene | 1993 |
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital | 1996 |
Rate parameter changes by added albumin in the microsomal oxidative demethylation of deuteriated and non-deuteriated 4-methoxyanisole.
Topics: Animals; Anisoles; Cytochrome P-450 Enzyme System; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Male; Methylation; Microsomes, Liver; Models, Chemical; Oxidation-Reduction; Phenobarbital; Rats; Rats, Wistar; Serum Albumin, Bovine; Substrate Specificity | 1996 |
Suppression by phenobarbital of ethionine-induced hepatocellular carcinoma formation and hepatic S-adenosylethionine levels.
Topics: Adenosine; Animals; Body Weight; Ethionine; Liver; Liver Neoplasms; Male; Methylation; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; S-Adenosylmethionine | 1997 |
The effect of gender, sexual maturation and xenobiotic treatment on the formation of hydroxymethyl metabolites from 7, 12-dimethylbenz[a]anthracene in rat liver microsomes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Female; Hypophysectomy; Isoenzymes; Male; Methylation; Microsomes, Liver; Phenobarbital; Rats; Rats, Long-Evans; Sex Factors; Sexual Maturation; Xenobiotics | 2000 |
The effect of temperature on monoxygenase reactions in the microsomal membrane.
Topics: Aminopyrine; Animals; Anisoles; Benzphetamine; Catalysis; Cell Membrane; Ethylmorphine; Ethylmorphine-N-Demethylase; Glycerol; Kinetics; Male; Methylation; Microsomes; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Long-Evans; Substrate Specificity; Temperature; Time Factors | 1977 |