phenobarbital has been researched along with ifosfamide in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Carde, P; Droz, JP; Flamant, F; Friedman, S; Ghosn, M; Hayat, M; Leclerq, B | 1 |
| Belisario, MA; Della Morte, R; Mugnoz, B; Remondelli, P; Staiano, N | 1 |
| Waxman, DJ; Weber, GF | 1 |
| Lokiec, F; Santoni, J; Tubiana-Hulin, M; Weill, S | 1 |
| Chang, TK; Maurel, P; Waxman, DJ; Yu, L | 1 |
| Chan, KK; Lu, H; Wang, JJ; Young, D | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Hecht, JE; Waxman, DJ; Yu, LJ | 1 |
| Faucette, S; Ferguson, S; LeCluyse, EL; Moore, R; Negishi, M; Sueyoshi, T; Wang, H | 1 |
| Savani, M; Skubitz, KM | 1 |
1 review(s) available for phenobarbital and ifosfamide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for phenobarbital and ifosfamide
| Article | Year |
|---|---|
Phenobarbital administration does not affect high-dose ifosfamide pharmacokinetics in humans.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Area Under Curve; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hypnotics and Sedatives; Ifosfamide; Male; Middle Aged; Osteosarcoma; Phenobarbital; Sarcoma; Soft Tissue Neoplasms; Spectrophotometry, Ultraviolet | 1996 |
15 other study(ies) available for phenobarbital and ifosfamide
| Article | Year |
|---|---|
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.
Topics: Adolescent; Brain Diseases; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Ifosfamide; Mercaptoethanol; Mesna; Phenobarbital | 1988 |
In vitro activation of isophosphamide and trophosphamide to metabolites mutagenic for bacteria.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cyclophosphamide; Drug Interactions; Ifosfamide; Liver; Male; Methylcholanthrene; Monoamine Oxidase Inhibitors; Mutagenicity Tests; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1986 |
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Topics: Animals; Antibodies; Biotransformation; Cisplatin; Clofibrate; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Ifosfamide; Kinetics; Male; Microsomes, Liver; Models, Chemical; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1993 |
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Biotransformation; Cells, Cultured; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Humans; Hydroxylation; Ifosfamide; Isoenzymes; Kinetics; Liver; Male; Middle Aged; Phenobarbital; Prodrugs; Rifampin | 1997 |
Effects of phenobarbital on stereoselective metabolism of ifosfamide in rats.
Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Ifosfamide; Male; Metabolic Clearance Rate; Phenobarbital; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1998 |
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1998 |
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Disease Models, Animal; Enzyme Induction; Female; Gliosarcoma; Half-Life; Hydroxylation; Ifosfamide; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1999 |
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
Topics: Amino Acid Motifs; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Constitutive Androstane Receptor; Cyclophosphamide; Cytochrome P-450 CYP2B6; Dimerization; Gene Expression Regulation; Genes, Reporter; Hepatocytes; Humans; Ifosfamide; Ligands; Liver; Luciferases; Mice; Microsomes, Liver; Mutagenesis, Site-Directed; Oxidoreductases, N-Demethylating; Phenobarbital; Plasmids; Pregnane X Receptor; Promoter Regions, Genetic; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Xenobiotics | 2003 |
Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cardiotoxicity; Dimethyl Sulfoxide; Doxorubicin; Female; Humans; Ifosfamide; Osteosarcoma; Phenobarbital; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2019 |