phenobarbital has been researched along with hexachlorobenzene in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (85.71) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Koole-Lesuis, H; van den Berg, JW; Visser, O; Voortman, G; Wilson, JH | 1 |
| Birse, LM; Bunce, NJ; Landers, JP; Nakai, JS; Winhall, MJ | 1 |
| Gutkina, NI; Liakhovich, VV; Mishin, VM | 1 |
| Robertson, LW; Rodman, LE; Shedlofsky, SI; Swim, AT | 1 |
| Bement, WJ; Goldstein, JA; Jacobs, JM; Lambrecht, RW; Sinclair, JF; Sinclair, PR | 1 |
| Billi, SC; San Martín de Viale, LC | 1 |
| Gutkina, NI; Mishin, VM | 1 |
| Bement, WJ; Elder, GH; Gorman, N; Lambrecht, RW; Roberts, AG; Sinclair, JA; Sinclair, PR; Urquhart, AJ | 1 |
| Hantelle, P; Kelley, M; Levin, W; Safe, S; Thomas, PE | 1 |
| Müller, F; Snoek, MC; van Berkel, WJ; van Bladeren, PJ; Vos, RM | 1 |
| Smith, AG; Stewart, FP | 2 |
| Elder, GH; Urquhart, AJ | 1 |
| Strobel, HW; Takazawa, RS | 1 |
| Adang, A; Müller, F; van Bladeren, PJ; van Ommen, B | 1 |
| Müller, F; Temmink, JH; van Bladeren, PJ; van Ommen, B | 1 |
| Buhler, DR; Carpenter, HM; Williams, DE | 1 |
| Henley, JP; Sadana, A | 1 |
| Goldstein, JA; Huckins, JN; Linko, P; Stalling, DL | 1 |
| Bender, RC; Buhler, DR; Carpenter, HM; Henderson, MC; Williams, DE | 1 |
| Campbell, MA; Gyorkos, J; Homonko, K; Leece, B; Safe, S | 1 |
| Ríos de Molina, MC; San Martin de Viale, LC; Taira de Yamasato, MC; Tomio, JM; Wainstok de Calmanovici, R | 1 |
| Damen, FJ; Mier, PD | 1 |
| Adzharov, D; Chernev, K; Ivanov, E | 1 |
| Burkhardt, F; Goerz, G; Vizethum, W | 1 |
| Grishanova, AIu; Guliaeva, LF; Liakhovich, VV | 1 |
28 other study(ies) available for phenobarbital and hexachlorobenzene
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Porphyrin synthesis by human hepatocytes and HepG2 cells--effects of enzyme inducers and delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Hexachlorobenzene; Humans; Hydroxymethylbilane Synthase; Liver; Liver Neoplasms; Methylcholanthrene; Phenobarbital; Porphyrins; Tumor Cells, Cultured; Uroporphyrinogen Decarboxylase | 1991 |
Chemically induced hepatic cytosol from the Sprague-Dawley rat: evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to components kinetically distinct from the Ah receptor.
Topics: Animals; Azo Compounds; Chlorobenzenes; Cytosol; Dioxins; Hexachlorobenzene; Liver; Male; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1990 |
[Induction of the phenobarbital form of cytochrome P-450 by chemically unrelated compounds].
Topics: Animals; Aroclors; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Hexachlorobenzene; Hexachlorocyclohexane; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture.
Topics: Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hexachlorobenzene; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Structure-Activity Relationship | 1989 |
Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d.
Topics: Animals; Antibodies; Chick Embryo; Cytochrome P-450 Enzyme System; Female; Hexachlorobenzene; Immunoblotting; Kidney; Methylcholanthrene; Microsomes, Liver; o-Aminoazotoluene; Oxazines; Oxidation-Reduction; Phenobarbital; Porphyrinogens; Rats; Uroporphyrinogens | 1989 |
Ability of several hexachlorobenzene metabolites to induce porphyrin accumulation in chick embryo liver "in ovo".
Topics: Animals; Chick Embryo; Chlorobenzenes; Hexachlorobenzene; Liver; Phenobarbital; Phenols; Porphyrias; Porphyrins; Sulfur | 1985 |
Immunochemical evidences that hexachlorobenzene induces two forms of cytochrome P-450 in the rat liver microsomes.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Hexachlorobenzene; Immunodiffusion; Immunoelectrophoresis; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachlorobenzene; Levulinic Acids; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Porphyrias; Porphyrins; Uroporphyrinogen Decarboxylase; Uroporphyrinogens | 1988 |
Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene.
Topics: Animals; Antibodies, Monoclonal; Azo Compounds; Chlorobenzenes; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation; Hexachlorobenzene; Immunosorbent Techniques; Isoenzymes; Microsomes, Liver; Oxidoreductases; p-Aminoazobenzene; Phenobarbital; Rats | 1987 |
Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Body Weight; Chlorobenzenes; Enzyme Induction; Glutathione Transferase; Hexachlorobenzene; Isoenzymes; Isothiocyanates; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Thiocyanates | 1988 |
Metabolism and covalent binding of hexachlorobenzene by isolated male and female rat hepatocytes.
Topics: Animals; Chlorobenzenes; Female; Hexachlorobenzene; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344; Sex Characteristics | 1987 |
Hexachlorobenzene-induced oxygen activation by mouse liver microsomes: comparison with phenobarbitone and 20-methylcholanthrene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxygen; Phenobarbital | 1987 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
Cytochrome P-450 mediated reductive dehalogenation of the perhalogenated aromatic compound hexachlorobenzene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hexachlorobenzene; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.
Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole | 1986 |
Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene.
Topics: Animals; Aroclors; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Chlorophenols; Chromatography, High Pressure Liquid; Female; Hexachlorobenzene; Male; Methylcholanthrene; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Coturnix; Electrophoresis, Polyacrylamide Gel; Female; Flavonoids; Hexachlorobenzene; Injections, Intraperitoneal; Liver Diseases; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxygenases; Phenobarbital; Porphyrias | 1985 |
A mathematical analysis of aging influences on enzyme deactivation/activation kinetics. Examples of the influence of regional brain development and drugs in rats.
Topics: 5-Aminolevulinate Synthetase; Aging; Animals; Brain; Carboxy-Lyases; Enzyme Activation; Female; Hexachlorobenzene; Models, Biological; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Structure-activity relationships of chlorinated benzenes as inducers of different forms of cytochrome P-450 in rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Chlorobenzenes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Female; Hexachlorobenzene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1982 |
Hexachlorobenzene-induced porphyria in Japanese quail. Effect of pretreatment with phenobarbital or beta-naphthoflavone.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Chlorobenzenes; Coturnix; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Flavonoids; Glutathione Transferase; Hexachlorobenzene; Liver; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Phenobarbital; Porphyrias | 1984 |
The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes.
Topics: Animals; Cyclohexanes; DDT; Enzyme Induction; Hexachlorobenzene; Insecticides; Liver; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Rats; Toxaphene | 1983 |
Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment.
Topics: 5-Aminolevulinate Synthetase; Animals; Carboxy-Lyases; Chlorobenzenes; Cytochrome P-450 Enzyme System; Female; Ferrochelatase; Hexachlorobenzene; Hydroxymethylbilane Synthase; Liver; Organ Size; Phenobarbital; Porphobilinogen Synthase; Porphyrias; Porphyrins; Rats; Rats, Inbred Strains | 1984 |
Cytochrome P-450-dependent O-dealkylase activity in mammalian skin.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adolescent; Adult; Animals; Cattle; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hexachlorobenzene; Humans; In Vitro Techniques; Kinetics; Liver; Macaca mulatta; Male; Methylcholanthrene; Mice; Mice, Hairless; Mice, Inbred A; Mice, Inbred BALB C; Oxygenases; Phenobarbital; Rabbits; Rats; Skin; Species Specificity | 1982 |
[Changes in liver microsomal enzymes and the synthesis of delta-aminolevulinic acid in short-term exposure of rabbits to allylisopropylacetamide, hexachlorobenzene and phenobarbital].
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Levulinic Acids; Microsomes, Liver; Phenobarbital; Rabbits; Time Factors | 1982 |
Enzymic and electrophoretic characterization of the hexachlorobenzene-induced cytochrome P-450 in the liver of rat.
Topics: Animals; Benzopyrenes; Chlorobenzenes; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Hexachlorobenzene; Hydrolysis; Liver; Microsomes, Liver; Phenobarbital; Rats | 1980 |
[Induction of cytochromes P-4501A and 2B in various rat organs, subjected to hexachlorobenzene and aroclor 1254].
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Isoenzymes; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Rats, Wistar | 1994 |