phenobarbital and heme

phenobarbital has been researched along with heme in 182 studies

Research

Studies (182)

Timeframe	Studies, this research(%)	All Research%
pre-1990	149 (81.87)	18.7374
1990's	22 (12.09)	18.2507
2000's	7 (3.85)	29.6817
2010's	3 (1.65)	24.3611
2020's	1 (0.55)	2.80

Authors

Authors	Studies
Bradshaw, JJ; Ivanetich, KM; Kaminsky, LS; Marsh, JA	1
Mungikar, AM; Pawar, SS	1
Benko, B; Jänig, GR; Maricic, A; Rein, H; Ristau, O; Ruckpaul, K; Vuk-Pavlovic, S	1
Coon, MJ; Haugen, DA	1
Ebel, RE; O'keeffe, DH; Peterson, JA	1
Benko, B; Butschak, G; Jänig, GR; Maricić, S; Rein, H; Ruckpaul, K; Scheunig, G	1
Azhary, RE; Jeffery, E; Kotake, A	1
Alvares, AP; Kappas, A	1
Farrell, GC; Kunze, KL; Ortiz de Montellano, PR; Schmid, R	1
Kirshenbaum, G; Lear, S; Way, LW	1
Burk, RF; Correia, MA	3
Bell, DY; Hodgson, E	1
Kreibich, G; Negishi, M	1
Mico, BA; Ortiz de Montellano, PR; Yost, GS	1
Hashimoto-Yutsudo, C; Imai, Y; Kitagawa, T; Kyogoku, Y; Ozaki, Y; Sato, R	1
de Matteis, F; Gibbs, AH; Järvisalo, J	1
de Matteis, F; Unseld, A	1
Correia, MA; Farrell, GC; Mico, BA; Ortiz de Montellano, PR; Schmid, R; Yost, GS	1
Galdhar, NR; Pawar, SS	1
Held, H	1
Bhat, KS; Padmanaban, G; Sardana, MK	1
Badawy, AA	1
Mackinnon, AM; Simon, FR	1
Correia, MA; Meyer, UA	1
Granick, S; Sinclair, PR	1
McDonagh, AF; Schmid, R	1
Padmanaban, G; Rajamanickam, C; Rao, MR	1
Deitrich, RA; Erwin, G; Troxell, PA	1
Cavallin-Stähl, E; Lundh, B; Mercke, C	1
Kimmett, SM; Mackie, JE; Marks, GS; McCluskey, SA; Riddick, DS; Whitney, RA	1
Padmanaban, G; Venkateswar, V	1
Ariyoshi, T; Arizono, K; Hasegawa, H; Matsumoto, H	1
Cánepa, ET; Grinstein, M; Llambías, EB	1
Bement, WJ; Guzelian, PS; Haugen, SA; Li, D; May, BK; Schuetz, EG; Sinclair, JF; Sinclair, PR	1
Marks, GS; Riddick, DS	1
Atsmon, A; Bomstein, Y; Mamet, R; Mevasser, R; Schoenfeld, N	1
Gelboin, HV; Marks, GS; Park, SS; Riddick, DS	2
Ignarro, LJ; Wood, KS	1
Correia, MA; Lunetta, JM	1
Bernhardt, R; Ruckpaul, K; Stiel, H	1
Hashimoto, Y; Kurata, N; Kuroiwa, Y; Masuko, T; Yoshida, T	1
Ades, IZ; Ryan, G	1
Bawden, MJ; Elliott, WH; Hansen, AJ; May, BK	1
Padmanaban, G; Rangarajan, PN	1
Fujino, S; Hoshi, K; Senda, N	1
Hansen, AJ; May, BK	1
Greinert, R; Hildebrandt, P; Stier, A; Stockburger, M; Taniguchi, H	1
Bawden, MJ; Hansen, AJ; May, BK; Srivastava, G	1
Cánepa, ET; Galvagno, MA; Grinstein, M; Llambías, EB; Passeron, S	1
Davies, HW; Pohl, LR; Thomas, PE	1
Bonkovsky, HL; Healey, JF; Lincoln, BC	1
Burke, MD; Kelly, K; Miles, JS; Rospendowski, BN; Seilman, S; Smith, WE; Wolf, CR	1
Bornheim, L; Caldera, P; Correia, MA; Decker, C; Rettie, AE; Sugiyama, K; Trager, WF; Wrighton, SA	1
Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G	1
Estabrook, RW; Weiss, RH	1
Rendić, S; Ruf, HH	1
Komives, EA; Ortiz de Montellano, PR	1
Engelmann, GL; Fierer, JA; Richardson, AG	1
Padmanaban, G; Ravishankar, H	2
Omura, T; Sadano, H	3
Padmanaban, G; Satyanarayana Rao, MR	1
Levin, W; Lu, AY; Ryan, D; West, S	1
Gayathri, AK; Padmanaban, G	1
Catz, C	1
Schenkman, JB	1
Gaylor, JL; Jefcoate, CR	1
Miyake, Y; Mori, K; Yamano, T	1
Baron, J; Tephly, TR	3
Bock, KW; Fröhling, W; Remmer, H	1
Padmanaban, G; Rao, MR	1
Kikuchi, G; Kim, HJ; Oashi, A; Tomita, Y; Watarai, K	1
Alvares, AP; Kappas, A; Mitani, F; Sassa, S	1
Bock, KW; Fröhling, W; Krauss, E	1
Coon, MJ; Dean, WL; Dus, K; Haugen, DA; Litchfield, WJ; Miguel, AG; van der Hoeven, TA	1
Berk, PD; Blaschke, TF; Collison, HA; Rodkey, FL; Scharschmidt, BF; Waggoner, JG	1
Padmanaban, G; Rajamanickam, C	1
Maisels, MJ	1
Druyan, R; Kelly, A	1
Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, S	1
De Matteis, F	2
Lacroix, S; Rothwell, JD; Sweeney, GD	1
Castro, JA; D'Acosta, N; de Castro, CR; de Fenos, OM; de Ferreyra, EC; Díaz Gòmez, MI	1
Malathi, K; Padmanaban, G; Rao, MR	2
Seifert, J	1
Siekevitz, P	1
Badawy, AA; Evans, M	1
Clark, C; Holtzman, JL; Montgomery, MR	1
Mason, JI; Schacter, BA	1
Anders, MW; Maines, MD; Muller-Eberhard, U	1
Nichol, AW	1
Wennberg, RP	1
Dehlinger, PJ; Schimke, RT	1
Imai, Y; Siekevitz, P	1
Alvares, A; Conney, AH; Kuntzman, R; Levin, W	1
Marver, HS; Meyer, UA	1
Alvares, AP; Kuntzman, R; Levin, W	1
White, P	1
Landaw, SA	1
Bond, EJ; De Matteis, F	1
Greim, H; Klotzbücher, M; Remmer, H; Schenkman, JB	1
Calabrese, RL; Gaylor, JL; Jefcoate, CR	1
Coburn, RF	1
Callahan, EW; Landaw, SA; Schmid, R	1
King, TE; Mason, HS; Oldham, S; Yong, FC	1
Hasegawa, E; Smith, C; Tephly, TR	1
Fouts, JR; Hewick, DS	1
Baron, J; Hasegawa, E; Tephly, TR	1
Gillette, JR; Greene, FE; Stripp, B	1
Israels, LG; Levitt, M; Schacter, BA; Zipursky, A	1
Del Favero, A; Gray, CH; Waterfield, MD	1
Crigler, JF; Lester, R; Robinson, SH; Tsong, M	1
Bradshaw, JJ; Ivanetich, KM; Ziman, MR	1
Padmanaban, G	1
Hakim, J; Järvisalo, J; Torres, M	1
Edwards, AM; Glistak, ML; Lucas, CM; Wilson, PA	1
Schmid, R	1
Sawabe, Y; Shimada, T	1
Maines, MD	1
Bonkovsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR; Smith, EL	1
Ahmed, AE; el-Azhary, RA	1
De Matteis, F; Marks, GS	1
Langry, KC; Ortiz de Montellano, PR; Stearns, RA	1
Bernhardt, R; Jänig, GR; Makower, A; Rabe, H; Ruckpaul, K	1
Atsmon, A; Epstein, O; Greenblat, Y; Lahav, M; Schoenfeld, N	1
Beilan, HS; Kunze, KL; Mangold, BL; Ortiz de Montellano, PR; Wheeler, C	1
Johnson, EF; Liem, HH; Muller-Eberhard, U	1
Beilan, HS; Kunze, KL; Ortiz de Montellano, PR	1
De Matteis, F; Gibbs, AH; Hollands, C	1
Percy, VA; Shanley, BC	1
Burk, RF; Jenkinson, SG; Lawrence, RA; Williams, DM	1
Kaliman, PA; Padalko, VI	1
Ibrahim, NG; Levere, RD; Nelson, JC	1
Althaus, FR; Giger, U; Hirsiger, H; Meier, PJ; Meyer, UA	1
Coon, MJ; White, RE	1
Fischer, VW; Hjelle, JJ; Poklis, A	1
Beilan, HS; Mathews, JM; Ortiz de Montellano, PR	1
Gasser, R; Hauri, HP; Meyer, UA	1
Beilan, HS; Kunze, KL; Mico, BA; Ortiz de Montellano, PR	1
Gidari, AS; Yeung, TC	1
Hatano, M; Iizuka, T; Ishimura, Y; Nozawa, T; Shimada, H; Shimizu, T	1
Kunze, KL; Ortiz de Montellano, PR	2
Giger, U; Meyer, UA	1
Burk, RF; Correia, MA; Lawrence, RA	1
Baird, MB	1
Correia, MA; Farrell, GC	1
Brooker, JD; Elliott, WH; Lim, LK; May, BK; Srivastava, G	1
Golly, I; Hlavica, P	1
Cvrk, T; Hodek, P; Strobel, HW	1
Kohli, KK; Ramana, KV	1
Ashwood-Smith, MJ; Baer-Dubowska, W; Cai, Y; Ceska, O; DiGiovanni, J; Tachibana, S	1
Kottari, S; Pelkonen, O; Raunio, H; Salonpää, P	1
Nirodi, CS; Padmanaban, G; Prabhu, L; Ram, N; Sultana, S	1
Buzaleh, AM; del Carmen Batlle, AM; Nuñez, G; Vazquez, ES	1
Albores, A; Eldirdiri, NI; Ferrara, R; King, LJ; Manno, M; Tolando, R	1
Canepa, ET; Grinstein, M; Llambias, EB; Varone, CL	1
Dwyer, B; Jacobs, J; Marek, D; Roberts, M; Roussel, R; Sinclair, J; Sinclair, P; Walton, H; Wood, S	1
Bogard, C; Daveau, M; Deybach, JC; Gauthier, F; Hiron, M; Lebreton, JP; Leplingard, A; Lyoumi, S; Nordmann, Y; Puy, H; Scotté, M; Tamion, F; Vranckx, R	1
Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T	1
Kawano, K; Kudo, S	1
Bonkovsky, HL; Elbirt, KK; Kolluri, S	1
Hoffmann, F; Jover, R; Lindberg, RL; Scheffler-Koch, V	1
Hoffmann, F; Lindberg, RL; Meyer, UA; Schuurmans, MM	1
Dennery, PA	1
Akagi, R; Fujii, H; Maeshima, K; Morita, K; Nakahira, K; Nakatsuka, H; Shimizu, H; Takahashi, T; Uehara, K; Yokoyama, M	1
Correia, MA; Han, XM; Hefner, C; Lee, G; Maher, JJ	1
Hollenberg, PF; Lin, HL; Zhang, H	1
Mehvar, R; Shaik, IH	1
Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I	1
Brown, FC; Conway, AJ; Curtis, DJ; Fullinfaw, RO; Jane, SM; Kile, BT	1
Bonkovsky, HL; Desnick, RJ; Gan, L; Pulgar, VM; Yasuda, M	1
Bishop, C; Bonkovsky, HL; Ma, CD; Van Horn, CG; Wan, M	1

Reviews

6 review(s) available for phenobarbital and heme

Article	Year
The enzymatic formation of bilirubin. Annals of the New York Academy of Sciences, 1975, Apr-15, Volume: 244 Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen	1975
The yellow baby. New York state journal of medicine, 1974, Volume: 74, Issue:5 Topics: Adolescent; Amniocentesis; Animals; Barbiturates; Bile; Bilirubin; Blood Transfusion, Intrauterine; Breast Feeding; Child, Preschool; Enzyme Induction; Exchange Transfusion, Whole Blood; Female; Glucuronosyltransferase; Heme; Hemolysis; Humans; Hyperbilirubinemia, Hereditary; Infant, Newborn; Jaundice, Neonatal; Liver; Maternal-Fetal Exchange; Mice; Movement Disorders; Phenobarbital; Phototherapy; Porphyrins; Pregnancy; Pregnanediol	1974
Bilirubin; on understanding and influencing its metabolism in the newborn infant. Pediatric clinics of North America, 1972, Volume: 19, Issue:2 Topics: Bile Pigments; Bilirubin; Exchange Transfusion, Whole Blood; Female; Fetus; Heme; Humans; Hyperbilirubinemia; Infant, Newborn; Kernicterus; Liver Circulation; Phenobarbital; Pregnancy	1972
What to do when the infant is jaundiced. Medical times, 1971, Volume: 99, Issue:11 Topics: Animals; Bilirubin; Diagnosis, Differential; Erythroblastosis, Fetal; Erythropoiesis; Exchange Transfusion, Whole Blood; Female; Heme; Hemoglobins; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Chronic Idiopathic; Jaundice, Neonatal; Kernicterus; Liver; Maternal-Fetal Exchange; Phenobarbital; Phototherapy; Pregnancy; Serum Albumin	1971
Hepatic heme metabolism: new aspects and speculations. Seminars in liver disease, 1983, Volume: 3, Issue:1 Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Microsomes, Liver; Phenobarbital; Rats	1983
Pharmacological interventions for the treatment of neonatal jaundice. Seminars in neonatology : SN, 2002, Volume: 7, Issue:2 Topics: Agar; Bilirubin; Charcoal; Clofibrate; Drugs, Chinese Herbal; Heme; Humans; Infant, Newborn; Jaundice, Neonatal; Liver Circulation; Metalloporphyrins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Penicillamine; Phenobarbital; Treatment Outcome	2002

Trials

1 trial(s) available for phenobarbital and heme

Article	Year
Heme catabolism during short-term treatment with phenobarbital, diazepam and oxazepam. Acta medica Scandinavica, 1975, Volume: 198, Issue:3 Topics: Adult; Bilirubin; Carbon Monoxide; Depression, Chemical; Diazepam; Heme; Hemoglobins; Humans; Male; Oxazepam; Phenobarbital; Stimulation, Chemical; Time Factors	1975

Other Studies

175 other study(ies) available for phenobarbital and heme

Article	Year
Fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome P-450 in vitro. Biochemical pharmacology, 1975, Nov-01, Volume: 24, Issue:21 Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Ethyl Ethers; Heme; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Time Factors	1975
Dioxane-induced changes in mouse liver microsomal mixed function oxidase system. Bulletin of environmental contamination and toxicology, 1976, Volume: 15, Issue:6 Topics: Animals; Ascorbic Acid; Cytochrome P-450 Enzyme System; Cytochromes; Dioxanes; Dioxins; Female; Heme; Lipid Metabolism; Liver; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADP; Organ Size; Oxidoreductases; Peroxides; Phenobarbital	1976
Haem accessibility in cytochrome P-450 from rabbit liver. A proton magnetic relaxation study by stereochemical probes. Biochimica et biophysica acta, 1976, Sep-28, Volume: 446, Issue:1 Topics: Binding Sites; Chromatography, Affinity; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Heme; Iron; Liver; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Phenobarbital; Protein Binding; Protein Conformation; Temperature	1976
Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. The Journal of biological chemistry, 1976, Dec-25, Volume: 251, Issue:24 Topics: Amino Acid Sequence; Amino Acids; Animals; Carbohydrates; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Female; Flavonoids; Heme; Male; Microsomes, Liver; Molecular Weight; Naphthalenes; Phenobarbital; Protein Conformation; Rabbits; Spectrophotometry; Spectrophotometry, Ultraviolet	1976
Studies of the unique nature of the cytochrome P-450 active site. Electron spin resonance spectroscopy as a probe of the hemin iron of cytochrome P-450: the influence of buffer composition, alcohols, and nitrogenous ligands. Archives of biochemistry and biophysics, 1977, Volume: 183, Issue:1 Topics: Alkanesulfonates; Animals; Binding Sites; Buffers; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Hemin; Male; Membranes; Methanol; Methylcholanthrene; Metyrapone; Microsomes, Liver; Morpholines; Phenobarbital; Pseudomonas; Rats	1977
Comparison of microsomal and solubilized monooxygenases from rat and rabbit by proton magnetic relaxation. Acta biologica et medica Germanica, 1979, Volume: 38, Issue:2-3 Topics: Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Iron; Kinetics; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Nitric Oxide; Oxygenases; Phenobarbital; Rabbits; Rats; Solubility; Species Specificity; Temperature	1979
Effects of linoleic acid hydroperoxide on the hepatic monooxygenase systems of microsomes from untreated, phenobarbital-treated, and 3-methylcholanthrene-treated rats. Molecular pharmacology, 1977, Volume: 13, Issue:3 Topics: Animals; Cytochrome Reductases; Drug Interactions; Glutathione; Heme; Hemeproteins; In Vitro Techniques; Linoleic Acids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Temperature; Time Factors	1977
Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls. The Journal of biological chemistry, 1977, Sep-25, Volume: 252, Issue:18 Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry	1977
Exogenous heme restores in vivo functional capacity of hepatic cytochrome P-450 destroyed by allylisopropylacetamide. Biochemical and biophysical research communications, 1979, Jul-27, Volume: 89, Issue:2 Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats	1979
Effect of phenobarbital on turnover of hepatic heme in rats. Surgical forum, 1979, Volume: 30 Topics: Animals; Bilirubin; Heme; Jaundice; Liver; Male; Phenobarbital; Postoperative Complications; Rats	1979
Accelerated hepatic haem catabolism in the selenium-deficient rat. The Biochemical journal, 1977, Oct-15, Volume: 168, Issue:1 Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Porphyrins; Proteins; Rats; Selenium	1977
SDS-polyacylamide gel electrophoresis of hepatic cytochrome P-450 from normal, 3-methylcholanthrene and phenobarbital treated mice. General pharmacology, 1977, Volume: 8, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Male; Methods; Methylcholanthrene; Mice; Microsomes, Liver; Molecular Weight; Phenobarbital; Sodium Dodecyl Sulfate	1977
Coordinated polypeptide synthesis and insertion of protoheme in cytochrome P-450 during development of endoplasmic reticulum membranes. The Journal of biological chemistry, 1978, Jul-10, Volume: 253, Issue:13 Topics: Animals; Animals, Newborn; Apoproteins; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Female; Heme; Liver; Male; Membranes; Microsomes, Liver; Phenobarbital; Rats	1978
Rapid stimulation of hepatic microsomal heme oxygenase in selenium-deficient rats. An effect of phenobarbital. The Journal of biological chemistry, 1978, Sep-10, Volume: 253, Issue:17 Topics: 5-Aminolevulinate Synthetase; Animals; Enzyme Induction; Heme; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Selenium	1978
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct. Biochemical and biophysical research communications, 1978, Jul-14, Volume: 83, Issue:1 Topics: Acetamides; Allylisopropylacetamide; Animals; Binding Sites; Cytochrome P-450 Enzyme Inhibitors; Heme; Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry	1978
Resonance Raman studies of hepatic microsomal cytochromes P-450: evidence for strong pi basicity of the fifth ligand in the reduced and carbonyl complex forms. Biochemistry, 1978, Dec-26, Volume: 17, Issue:26 Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Hemeproteins; Ligands; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Conformation; Rabbits; Spectrum Analysis, Raman	1978
Accelerated conversion of heme to bile pigments caused in the liver by carbon disulfide and other sulfur-containing chemicals. Molecular pharmacology, 1978, Volume: 14, Issue:6 Topics: Animals; Bile Pigments; Carbon Disulfide; Cycloheximide; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Sulfur	1978
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone. The International journal of biochemistry, 1978, Volume: 9, Issue:12 Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine	1978
Incorporation of exogenous heme into hepatic cytochrome P-450 in vivo. The Journal of biological chemistry, 1979, Jan-10, Volume: 254, Issue:1 Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Subcellular Fractions	1979
Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1976, Volume: 46, Issue:1 Topics: Acetanilides; Aminopyrine; Aniline Compounds; Animals; Biotransformation; Body Weight; Cytochromes; Electron Transport; Female; Heme; Inactivation, Metabolic; Lipid Metabolism; Liver; Male; Microsomes, Liver; Morphine Derivatives; NADPH-Ferrihemoprotein Reductase; Organ Size; Oxidation-Reduction; Phenobarbital; Rats; Thiamine Deficiency	1976
Effect of alcohol on the heme and porphyrin synthesis interaction with phenobarbital and pyrazole. Digestion, 1977, Volume: 15, Issue:2 Topics: 5-Aminolevulinate Synthetase; Adenosine Triphosphate; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Ethanol; Heme; Liver; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Porphyrins; Pyrazoles; Rats; Rats, Inbred Strains; Starvation; Time Factors	1977
Role of haem in the synthesis and assembly of cytochrome P-450. The Biochemical journal, 1977, May-15, Volume: 164, Issue:2 Topics: Aminolevulinic Acid; Animals; Apoenzymes; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Hemin; Male; Microsomes, Liver; Phenobarbital; Rats; Triazoles	1977
The effects of acetate, metal cations, phenobarbitone, porphyrogens and substrates of glycine acyltransferase on the utilization of haem by rat liver apo-(tryptophan pyrrolase). The Biochemical journal, 1977, May-15, Volume: 164, Issue:2 Topics: 5-Aminolevulinate Synthetase; Acetates; Animals; Apoenzymes; Benzoates; Ferrochelatase; Heme; Liver; Male; Metals; Phenobarbital; Porphobilinogen Synthase; Porphyrinogens; Rats; Stimulation, Chemical; Tryptophan Oxygenase	1977
Impaired hepatic heme synthesis in the phenobarbital-stimulated selenium-deficient rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 152, Issue:4 Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Selenium; Stimulation, Chemical	1976
Hepatic heme metabolism in selenium-deficient rats: effect of phenobarbital. Archives of biochemistry and biophysics, 1976, Volume: 177, Issue:2 Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Selenium; Spleen	1976
Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro. Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:1 Topics: Animals; Apoproteins; Binding Sites; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Enzyme Inhibitors; Enzyme Precursors; Heme; Hemin; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats	1975
Heme control on the synthesis of delta-aminolevulinic acid synthetase in cultured chick embryo liver cells. Annals of the New York Academy of Sciences, 1975, Apr-15, Volume: 244 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Deferoxamine; Enzyme Induction; Heme; Hemin; Kinetics; Lead; Levulinic Acids; Liver; Phenobarbital; Protein Biosynthesis; Transcription, Genetic	1975
On the sequence of reactions leading to cytochrome P-450 synthesis-effect of drugs. The Journal of biological chemistry, 1975, Mar-25, Volume: 250, Issue:6 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Apoproteins; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Endoplasmic Reticulum; Glycine; Heme; Iron; Liver; Male; Microsomes, Liver; Phenobarbital; Rats	1975
Characteristics of the induction of aldehyde dehydrogenase in rat liver. Archives of biochemistry and biophysics, 1975, Volume: 166, Issue:2 Topics: Aldehyde Oxidoreductases; Allylisopropylacetamide; Animals; Cycloheximide; Cytosol; Enzyme Induction; Heme; Liver; Phenobarbital; Rats; Species Specificity; Time Factors	1975
Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:8 Topics: Animals; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Dicarbethoxydihydrocollidine; Ferrochelatase; Heme; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Zinc	1992
Involvement of heme in the transcriptional activation of CYPIIB1/B2 gene by phenobarbitone in rat liver--studies with succinylacetone. Archives of biochemistry and biophysics, 1991, Volume: 290, Issue:1 Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Heptanoates; In Vitro Techniques; Liver; Male; Phenobarbital; Porphobilinogen Synthase; Rats; RNA, Messenger; Transcription, Genetic	1991
Effects of surfactants on the contents of metallothionein, heme and hemoproteins and on the activities of heme oxygenase and drug-metabolizing enzymes in rats pretreated with phenobarbital or beta-naphthoflavone. Bulletin of environmental contamination and toxicology, 1991, Volume: 46, Issue:1 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Liver; Male; Metallothionein; Mixed Function Oxygenases; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Surface-Active Agents; Zinc	1991
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of insulin. Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, Volume: 68, Issue:6 Topics: 5-Aminolevulinate Synthetase; Animals; Cyclic AMP; Cytochrome P-450 Enzyme System; Dexamethasone; Diabetes Mellitus, Experimental; Enzyme Induction; Ferrochelatase; Glucagon; Heme; In Vitro Techniques; Insulin; Liver; Male; Phenobarbital; Rats	1990
Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix. Archives of biochemistry and biophysics, 1990, Nov-01, Volume: 282, Issue:2 Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Enzyme Induction; Extracellular Matrix; Heme; Heptanoates; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344; RNA, Messenger	1990
Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. Biochemical pharmacology, 1990, Oct-15, Volume: 40, Issue:8 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Rats; Rats, Inbred Strains	1990
L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver. Biochimica et biophysica acta, 1990, May-16, Volume: 1034, Issue:2 Topics: Alanine; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Liver; Male; Phenobarbital; Porphyrins; Rats; Rats, Inbred Strains; Transaminases; Valerates	1990
Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats. Molecular pharmacology, 1990, Volume: 37, Issue:1 Topics: Animals; Apoproteins; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Immunologic Techniques; Male; Microsomes, Liver; Phenobarbital; Rats; Structure-Activity Relationship; Time Factors	1990
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase. The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine	1987
Acute hepatic heme depletion: impaired gluconeogenesis in rats. Seminars in hematology, 1989, Volume: 26, Issue:2 Topics: Animals; Brain; Dicarbethoxydihydrocollidine; Gluconeogenesis; Glutathione; Glycerol; Heme; Hydroxyindoleacetic Acid; Liver; Phenobarbital; Porphyrias; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase	1989
Distance between lysine 384 and heme of cytochrome P-450 LM2 (P-450 IIB4) studied by fluorescence energy transfer measurements. Biochemical and biophysical research communications, 1989, Sep-29, Volume: 163, Issue:3 Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Heme; Lysine; Male; Microsomes, Liver; Phenobarbital; Protein Conformation; Rabbits; Spectrometry, Fluorescence; Thiocyanates	1989
Long-term effects of phenobarbital on rat liver microsomal drug-metabolizing enzymes and heme-metabolizing enzyme. Research communications in chemical pathology and pharmacology, 1989, Volume: 65, Issue:2 Topics: 5-Aminolevulinate Synthetase; Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors	1989
Coordinate elevations of liver delta-aminolevulinate synthase and cytochrome P-450 RNA by phenobarbital in chicken embryos: the effects of heme. The International journal of biochemistry, 1989, Volume: 21, Issue:9 Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; DNA Probes; Enzyme Induction; Heme; Hemin; Liver; Nucleic Acid Hybridization; Phenobarbital; RNA, Messenger	1989
Regulation of genes associated with drug metabolism. Biochemical Society symposium, 1989, Volume: 55 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Amino Acid Sequence; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Activation; Gene Expression Regulation; Heme; Humans; Inactivation, Metabolic; Liver; Molecular Sequence Data; Phenobarbital; Rats; RNA, Messenger; Transcription, Genetic; Transcriptional Activation	1989
Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver. Molecular pharmacology, 1989, Volume: 35, Issue:5 Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Isoenzymes; Male; NADP; Phenobarbital; Rats; Rats, Inbred Strains	1989
Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:11 Topics: Animals; Base Sequence; Cell Nucleus; Cloning, Molecular; Cycloheximide; Cytochrome P-450 Enzyme System; Exons; Gene Expression Regulation; Genes; Heme; Liver; Molecular Sequence Data; Phenobarbital; Rats; Reference Values; Transcription Factors; Transcription, Genetic	1989
Acute effect of amitriptyline, phenobarbital or cobaltous chloride on delta-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver. Japanese journal of pharmacology, 1989, Volume: 50, Issue:3 Topics: 5-Aminolevulinate Synthetase; Amitriptyline; Animals; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains	1989
Effect of haem on cytochrome P-450 synthesis. Clinical and experimental pharmacology & physiology, 1989, Volume: 16, Issue:6 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation; Heme; Heptanoates; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Messenger; Steroid 11-beta-Hydroxylase	1989
Surface enhanced resonance Raman study of phenobarbital-induced rabbit liver cytochrome P-450 LM2. FEBS letters, 1988, Jan-18, Volume: 227, Issue:1 Topics: Adsorption; Animals; Colloids; Cytochrome P-450 Enzyme System; Cytochromes; Electrodes; Heme; Liposomes; Microsomes, Liver; Nonoxynol; Oxidation-Reduction; Phenobarbital; Polyethylene Glycols; Rabbits; Silver; Solubility; Spectrum Analysis, Raman	1988
Heme may not be a positive regulator of cytochrome-P450 gene expression. European journal of biochemistry, 1989, Jan-02, Volume: 178, Issue:3 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Gene Expression Regulation; Genes; Heme; Humans; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Transcription, Genetic	1989
Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats. Biochimica et biophysica acta, 1985, Nov-20, Volume: 847, Issue:2 Topics: 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cyclic AMP; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Ferrochelatase; Glucose; Heme; Homeostasis; In Vitro Techniques; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values	1985
Activation of cytochrome P-450 heme in vivo. Advances in experimental medicine and biology, 1986, Volume: 197 Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Activation; Heme; Immunodiffusion; Isoenzymes; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Tritium	1986
Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals. The Biochemical journal, 1988, Feb-15, Volume: 250, Issue:1 Topics: Animals; Cations, Divalent; Cells, Cultured; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Glutethimide; Heme; Heme Oxygenase (Decyclizing); Liver; Mephenytoin; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Porphyrins	1988
Evidence that the catalytic differences of two structurally homologous forms of cytochrome P-450 relate to their heme environment. Biochemistry, 1988, Mar-08, Volume: 27, Issue:5 Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Isoenzymes; Kinetics; Male; Microsomes, Liver; Peptide Mapping; Phenobarbital; Rats; Rats, Inbred Strains; Spectrum Analysis, Raman; Substrate Specificity	1988
Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts. Archives of biochemistry and biophysics, 1987, Nov-01, Volume: 258, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains	1987
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme. The Journal of biological chemistry, 1987, Dec-15, Volume: 262, Issue:35 Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger	1987
The mechanism of cumene hydroperoxide-dependent lipid peroxidation: the function of cytochrome P-450. Archives of biochemistry and biophysics, 1986, Nov-15, Volume: 251, Issue:1 Topics: Animals; Benzene Derivatives; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanol; Fibric Acids; Heme; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipid Peroxides; Male; Microsomes, Liver; Oxygen; Phenobarbital; Rats; Substrate Specificity	1986
Characterization of pirenzepine interaction with cytochrome P-450. Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:5 Topics: 7-Alkoxycoumarin O-Dealkylase; Adolescent; Animals; Benzodiazepinones; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Heme; Humans; Ligands; Microsomes, Liver; Oxygenases; Phenobarbital; Pirenzepine; Rats; Rats, Inbred Strains; Species Specificity; Substrate Specificity; Swine	1985
Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450. The Journal of biological chemistry, 1985, Mar-25, Volume: 260, Issue:6 Topics: Acetylene; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Heme; Kinetics; Microsomes, Liver; Oxygen; Phenobarbital; Phenylacetates; Rats	1985
Maintenance and induction of cytochrome P-450 in cultured rat hepatocytes. Archives of biochemistry and biophysics, 1985, May-01, Volume: 238, Issue:2 Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Heme; Liver; Microsomes, Liver; Phenobarbital; Rats; Selenium	1985
Turnover of messenger RNA, apoprotein and haem of cytochrome P-450b + e induced by phenobarbitone in rat liver. The Biochemical journal, 1985, Jul-01, Volume: 229, Issue:1 Topics: 5-Aminolevulinate Synthetase; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Heme; Liver; Male; Phenobarbital; Rats; RNA, Messenger	1985
Incorporation of heme to microsomal cytochrome P-450 in the absence of protein biosynthesis. Journal of biochemistry, 1985, Volume: 98, Issue:5 Topics: Aminolevulinic Acid; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytosol; Heme; In Vitro Techniques; Leucine; Male; Microsomes, Liver; Phenobarbital; Precipitin Tests; Rats; Rats, Inbred Strains	1985
delta-aminolaevulate synthetase induction and catalase repression by porphyrinogenic drugs. The Biochemical journal, 1971, Volume: 122, Issue:4 Topics: 5-Aminolevulinate Synthetase; Acetamides; Acyltransferases; Allyl Compounds; Amino Acids; Animals; Bilirubin; Catalase; Dicarboxylic Acids; Enzyme Induction; Enzyme Repression; Esters; Female; Heme; Hexachlorocyclohexane; Liver; Mice; Phenobarbital; Porphyrins; Pyridines; Rats	1971
Preparation of partially purified, lipid-depleted cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rat liver microsomes. The Journal of biological chemistry, 1974, Mar-25, Volume: 249, Issue:6 Topics: Animals; Cholic Acids; Chromatography, DEAE-Cellulose; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Detergents; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Rats; Spectrophotometry; Ultrafiltration	1974
Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver. Biochemical pharmacology, 1974, Oct-01, Volume: 23, Issue:19 Topics: Allylisopropylacetamide; Aniline Compounds; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dicarboxylic Acids; Female; Heme; Iron Radioisotopes; Kinetics; Leucine; Lipid Metabolism; Liver; Mice; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Organ Size; Phenobarbital; Phospholipids; Protein Biosynthesis; Pyridines; Ribonucleases; RNA	1974
Studies on the nature of the type I and type II spectral changes in liver microsomes. Biochemistry, 1970, May-12, Volume: 9, Issue:10 Topics: Aniline Compounds; Animals; Benzopyrenes; Binding Sites; Cytochromes; Heme; Hexobarbital; Male; Microsomes, Liver; Niacinamide; Phenobarbital; Proteins; Rats; Spectrophotometry; Ultraviolet Rays	1970
Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra. Biochemistry, 1969, Volume: 8, Issue:8 Topics: Amines; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Heme; Imidazoles; Liver; Male; Methylcholanthrene; Microsomes; Myoglobin; Phenobarbital; Protein Biosynthesis; Rabbits; Spectrophotometry; Stimulation, Chemical	1969
A study on some spectral properties of P-450 in a submicrosomal particle. Archives of biochemistry and biophysics, 1969, Volume: 133, Issue:2 Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cyanides; Cytochromes; Electron Spin Resonance Spectroscopy; Heme; Liver; Microsomes; Nitric Oxide; Oxidation-Reduction; Phenobarbital; Proteins; Rabbits; Spectrophotometry	1969
Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations. Archives of biochemistry and biophysics, 1970, Volume: 139, Issue:2 Topics: Animals; Benzopyrenes; Carbon Isotopes; Cytochromes; Enzyme Activation; Heme; Levulinic Acids; Ligases; Liver; Male; Microsomes, Liver; NAD; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Proteins; Rats; Stimulation, Chemical	1970
Influence of fasting and hemin on microsomal cytochromes and enzymes. Biochemical pharmacology, 1973, Jul-01, Volume: 22, Issue:13 Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Enzyme Induction; Fasting; Glucose-6-Phosphatase; Glycogen; Half-Life; Heme; Hydrolases; In Vitro Techniques; Levulinic Acids; Male; Microsomes, Liver; NAD; Phenobarbital; Rats; Tritium	1973
Biochemical effects of the porphyrinogenic drug allylisopropylacetamide. A comparative study with phenobarbital. The Biochemical journal, 1973, Volume: 134, Issue:4 Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Heme; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Phospholipids; Proteins; Rats; Ribonucleases; RNA	1973
Comparative study on induction of hepatic delta-aminolevulinate synthetase by different drugs. Enzyme, 1973, Volume: 16, Issue:1 Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Bucladesine; Cells, Cultured; Chick Embryo; Cycloheximide; Cytosol; Dicarboxylic Acids; Enzyme Induction; Heme; Liver; Mitochondria, Liver; Phenobarbital; Pyridines; Rats; Species Specificity; Time Factors	1973
The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene. Biochemical and biophysical research communications, 1969, Aug-15, Volume: 36, Issue:4 Topics: Acyltransferases; Amino Acids; Animals; Azo Compounds; Benzopyrenes; Carbon Isotopes; Cytochromes; Depression, Chemical; Enzyme Induction; Glycine; Heme; Levulinic Acids; Liver; Male; Microsomes; NADP; Oxidoreductases; Phenobarbital; Rats; Stimulation, Chemical; Time Factors; Transferases; Triazoles	1969
Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital. Molecular pharmacology, 1969, Volume: 5, Issue:1 Topics: Animals; Azo Compounds; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Hydro-Lyases; Iron Isotopes; Levulinic Acids; Male; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Time Factors; Triazoles	1969
Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes. Molecular pharmacology, 1971, Volume: 7, Issue:3 Topics: Acetamides; Allyl Compounds; Animals; Bacillus subtilis; Carbon Monoxide; Cell Fractionation; Chick Embryo; Cytochromes; Depression, Chemical; Detergents; Etiocholanolone; Female; Flavins; Heme; Ketosteroids; Liver; Methods; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Nitrogen; Oxidoreductases; Peptide Hydrolases; Phenobarbital; Pregnanes; Rats; Solubility; Spectrophotometry; Stimulation, Chemical	1971
Regulation of -aminolevulinic acid synthetase by drugs and steroids in vivo and in isolated perfused rat liver. European journal of biochemistry, 1971, Nov-11, Volume: 23, Issue:2 Topics: 5-Aminolevulinate Synthetase; Acetamides; Acyltransferases; Allyl Compounds; Amino Acids; Animals; Cattle; Cytochromes; Dexamethasone; Enzyme Induction; Erythrocytes; Etiocholanolone; Heme; Hydrocortisone; In Vitro Techniques; Levulinic Acids; Liver; Male; Perfusion; Phenobarbital; Rats; Starvation; Stimulation, Chemical; Testosterone; Tyrosine Transaminase	1971
Structural resemblance of cytochrome P-450 isolated from Pseudomonas putida and from rabbit liver microsomes. Biochemical and biophysical research communications, 1974, Sep-09, Volume: 60, Issue:1 Topics: Amino Acids; Animals; Binding Sites; Binding Sites, Antibody; Cross Reactions; Cyanogen Bromide; Cytochrome P-450 Enzyme System; Heme; Isotope Labeling; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Peptides; Phenobarbital; Phospholipids; Protein Binding; Pseudomonas; Rabbits; Solubility; Species Specificity; Spectrophotometry, Ultraviolet	1974
Drugs and the liver. I. Effects of glutethimide and phenobarbital on hepatic bilirubin clearance, plasma bilirubin turnover and carbon monoxide production in man. Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20 Topics: Bilirubin; Carbon Monoxide; Carbon Radioisotopes; Chromium Radioisotopes; Female; Gilbert Disease; Glutethimide; Half-Life; Heme; Humans; Liver; Male; Phenobarbital; Time Factors; Tritium	1974
Biochemical effects of hexachlorobenzene. Indian journal of biochemistry & biophysics, 1974, Volume: 11, Issue:2 Topics: Animals; Chlorobenzenes; Female; Fungicides, Industrial; Heme; Liver; Phenobarbital; Rats	1974
The effect of exogenous -aminolaevulinate on rat liver haem and cytochromes. The Biochemical journal, 1972, Volume: 129, Issue:5 Topics: 5-Aminolevulinate Synthetase; Amides; Animals; Carbon Isotopes; Cytochromes; Heme; Levulinic Acids; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Spectrophotometry; Tryptophan Oxygenase	1972
Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes. Archives of biochemistry and biophysics, 1972, Volume: 153, Issue:2 Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Carbon Isotopes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electrophoresis, Polyacrylamide Gel; Heme; Hexobarbital; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Phospholipids; Protein Binding; Rats; Sodium Dodecyl Sulfate; Solubility; Spectrophotometry; Spectrophotometry, Ultraviolet; Tritium	1972
The effects of drugs on the activities of 5-aminolaevulinate synthetase and other enzymes in the pathway of haem biosynthesis. The Biochemical journal, 1972, Volume: 130, Issue:2 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarboxylic Acids; Esters; Griseofulvin; Heme; Liver; Mice; Phenobarbital; Phenylbutazone; Porphyrias; Pyridines; Rats	1972
Evidence against a regulatory role for heme oxygenase in hepatic heme synthesis. Biochimica et biophysica acta, 1973, May-28, Volume: 304, Issue:3 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Spleen; Starvation	1973
Role of cytochrome P-450 in carbon tetrachloride activation and CCl 4-induced necrosis. Effect of inhibitors of heme synthesis. I. 3-Amino-1,2,4 triazole. Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:1 Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Female; Heme; Lipid Metabolism; Liver; Male; Microsomes, Liver; Necrosis; Organ Size; Phenobarbital; Triazoles	1973
A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver. The Biochemical journal, 1973, Volume: 134, Issue:4 Topics: 5-Aminolevulinate Synthetase; Adrenalectomy; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Castration; Citrates; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Female; Heme; Hydrocortisone; Iron Radioisotopes; Liver; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Protein Binding; Rats	1973
Tryptophan pyrrolase in rat liver after phenobarbital administration. Toxicology, 1973, Volume: 1, Issue:3 Topics: Animals; Ascorbic Acid; Dactinomycin; Enzyme Activation; Enzyme Induction; Heme; Hydrocortisone; Liver; Male; Phenobarbital; Proteins; Rats; Time Factors; Tryptophan; Tryptophan Oxygenase	1973
The differentiation of rat liver endoplasmic reticulum membranes: apo--cytochrome P450 as a membrane protein. Journal of supramolecular structure, 1973, Volume: 1, Issue:6 Topics: Animals; Apoproteins; Cell Differentiation; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Female; Fetus; Heme; Liver; Male; Membranes; Microsomes, Liver; Molecular Weight; Phenobarbital; Pregnancy; Protein Binding; Rats; Sodium Dodecyl Sulfate; Solubility; Time Factors	1973
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase. The Biochemical journal, 1973, Volume: 136, Issue:4 Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxylic Acids; Griseofulvin; Heme; Humans; Hydrocortisone; Levulinic Acids; Liver; Male; Mental Disorders; Microsomes; Phenobarbital; Phenylbutazone; Porphyrias; Proadifen; Protein Precursors; Pyridines; Rats; Starvation; Time Factors; Tryptophan; Tryptophan Oxygenase	1973
Iron species of hepatic microsomes from control and phenobarbital-treated rats. Archives of biochemistry and biophysics, 1974, Volume: 160, Issue:1 Topics: Animals; Calcium; Chromatography, Affinity; Cytochrome P-450 Enzyme System; Cytochromes; Ferritins; Heme; Horses; Iron; Male; Metalloproteins; Microsomes, Liver; Phenobarbital; Potassium Chloride; Rats; Sulfur; Time Factors; Ultracentrifugation	1974
The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450. Archives of biochemistry and biophysics, 1974, Volume: 160, Issue:1 Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Heme; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Spleen; Time Factors	1974
Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins. Molecular pharmacology, 1974, Volume: 10, Issue:2 Topics: Animals; Apoproteins; Biological Transport; Blood Proteins; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Hemeproteins; Hemopexin; In Vitro Techniques; Levulinic Acids; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Serum Albumin; Spectrophotometry, Ultraviolet; Tritium	1974
The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors. Biochimica et biophysica acta, 1970, Oct-27, Volume: 222, Issue:1 Topics: Acetanilides; Animals; Ascorbic Acid; Azides; Bile Pigments; Carbon Monoxide; Chickens; Chloramphenicol; Culture Techniques; Cyanides; Cycloheximide; Dactinomycin; Erythrocytes; Ethylmaleimide; Female; Heme; Hydrogen Peroxide; Macrophages; Metabolism; Microscopy, Phase-Contrast; Mitomycins; Phagocytosis; Phenobarbital; Proadifen; Quinacrine; Spectrophotometry; Spectrum Analysis; Stimulation, Chemical; Triazoles	1970
Effects of phenobarbital, 3-methylcholanthrene, and hematin on the synthesis of protein components of rat liver microsomal membranes. The Journal of biological chemistry, 1972, Feb-25, Volume: 247, Issue:4 Topics: Animals; Carbon Isotopes; Cytochromes; Electrophoresis; Endoplasmic Reticulum; Heme; Leucine; Male; Membranes; Metabolism; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Sodium Dodecyl Sulfate; Solubility; Tritium	1972
The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver. The Biochemical journal, 1972, Volume: 127, Issue:3 Topics: 5-Aminolevulinate Synthetase; Amides; Animals; Bilirubin; Catalase; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucose; Half-Life; Heme; Liver; Microsomes, Liver; Phenobarbital; Porphyrins; Proadifen; Rats	1972
A comparison of some properties of microsomal cytochrome P-450 from normal, methylcholanthrene-, and phenobarbital-treated rats. Archives of biochemistry and biophysics, 1971, Volume: 144, Issue:1 Topics: 1-Propanol; Amines; Animals; Chemical Phenomena; Chemistry; Chlorides; Cycloheximide; Cytochromes; Fasting; Fatty Alcohols; Heme; Hydrogen-Ion Concentration; Kinetics; Male; Mathematics; Mercury; Methylcholanthrene; Microsomes, Liver; Nitriles; Oxidation-Reduction; Phenobarbital; Potassium; Protein Biosynthesis; Rats; Spectrophotometry; Sulfites; Thiocyanates; Triazoles	1971
Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide. The Biochemical journal, 1971, Volume: 124, Issue:4 Topics: Acetamides; Allyl Compounds; Amides; Amino Acids; Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Iron Isotopes; Levulinic Acids; Ligases; Liver; Male; Microsomes, Liver; Phenobarbital; Pigments, Biological; Porphyrias; Proadifen; Rats; Tritium	1971
Chromatography of radioactive microsomal hemoproteins on diethylaminoethyl cellulose. Molecular pharmacology, 1971, Volume: 7, Issue:5 Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochromes; Heme; Kinetics; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Solubility; Time Factors; Tritium	1971
Porphyrin biosynthesis. Enhancement of the fractional catabolic rate of microsomal haem in chemically induced porphyria. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Sep-25 Topics: 5-Aminolevulinate Synthetase; Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Iron Isotopes; Liver; Male; Microsomes, Liver; Phenobarbital; Porphyrias; Porphyrins; Rats; Tritium	1971
Effects of inducers of liver microsomal enzymes on the composition of microsomal hemoprotein. Advances in cytopharmacology, 1971, Volume: 1 Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlordan; Cytochromes; Enzyme Induction; Heme; Hemeproteins; Hydroxylation; In Vitro Techniques; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Time Factors; Tritium	1971
Carbon monoxide production and heme catabolism. Annals of the New York Academy of Sciences, 1970, Oct-05, Volume: 174, Issue:1 Topics: Acetamides; Allyl Compounds; Anemia, Sideroblastic; Animals; Bile Pigments; Bone Marrow; Carbon Isotopes; Carbon Monoxide; Dogs; Erythrocytes; Erythropoiesis; Glycine; Heme; Hemoglobins; Humans; Levulinic Acids; Liver; Mononuclear Phagocyte System; Phenobarbital; Porphyrias; Reticulocytes; Time Factors	1970
Kinetic aspects of endogenous carbon monoxide production in experimental animals. Annals of the New York Academy of Sciences, 1970, Oct-05, Volume: 174, Issue:1 Topics: Acetamides; Allyl Compounds; Anemia, Hypochromic; Animals; Birds; Blood Transfusion; Carbon Isotopes; Carbon Monoxide; Cell Survival; Erythrocyte Aging; Erythropoiesis; Female; Glycine; Hematocrit; Heme; Hemoglobins; Hemolysis; Iron Isotopes; Kinetics; Male; Methods; Mice; Phenobarbital; Phenylhydrazines; Rats; Reticulocytes; Time Factors; Veins	1970
Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes. Biochemical pharmacology, 1969, Volume: 18, Issue:10 Topics: Adjuvants, Anesthesia; Aniline Compounds; Animals; Anisoles; Blood Proteins; Body Weight; Carbon Disulfide; Carbon Isotopes; Cycloheximide; Cytochromes; DNA; Fasting; Heme; Injections, Intraperitoneal; Leucine; Lipids; Liver; Liver Glycogen; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Organ Size; Phenobarbital; Proadifen; Protein Biosynthesis; Proteins; Rats; RNA; Spectrophotometry; Sucrose; Time Factors	1969
The influence of phenobarbital on the turnover of hepatic microsomal cytochrome b5 and cytochrome P-450 hemes in the rat. Biochimica et biophysica acta, 1970, Jan-27, Volume: 201, Issue:1 Topics: Animals; Carbon Isotopes; Cytochromes; Heme; Levulinic Acids; Male; Microsomes, Liver; Phenobarbital; Rats; Time Factors	1970
Ligand interaction with hemoprotein P-450. 3. The use of n-octylamine and ethyl isocyanide difference spectroscopy in the quantitative determination of high- and low-spin P-450. Molecular pharmacology, 1970, Volume: 6, Issue:4 Topics: Adrenal Glands; Amines; Animal Feed; Animals; Cattle; Cyanides; Heme; Male; Methods; Microsomes, Liver; Oxytetracycline; Phenobarbital; Protein Binding; Proteins; Rabbits; Spectrum Analysis	1970
Enhancement by phenobarbital and diphenylhydantoin of carbon monoxide production in normal man. The New England journal of medicine, 1970, Sep-03, Volume: 283, Issue:10 Topics: Adult; Bilirubin; Carbon Monoxide; Heme; Humans; Liver; Male; Phenobarbital; Phenytoin	1970
Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide. The Journal of clinical investigation, 1970, Volume: 49, Issue:5 Topics: Animals; Bile; Bilirubin; Carbon Isotopes; Carbon Monoxide; Feces; Glycine; Heme; Injections, Intravenous; Liver; Phenobarbital; Rats; Respiration; Urea	1970
Redox-dependent conformational changes of rabbit liver cytochrome P-450. Archives of biochemistry and biophysics, 1970, Volume: 138, Issue:1 Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cytochromes; Endoplasmic Reticulum; Heme; Liver; Microsomes, Liver; Optical Rotatory Dispersion; Oxidation-Reduction; Phenobarbital; Pigments, Biological; Rabbits; Spectrophotometry; Ultraviolet Rays	1970
Induction of hepatic mitochondrial ferrochelatase by phenobarbital. Biochemical and biophysical research communications, 1970, Aug-11, Volume: 40, Issue:3 Topics: Acyltransferases; Animals; Cobalt; Cycloheximide; Enzyme Induction; Heme; Kinetics; Levulinic Acids; Liver; Lyases; Male; Metabolism; Mitochondria, Liver; Nickel; Oxygen; Phenobarbital; Porphyrins; Rats; Succinates	1970
Effects of storage on hepatic microsomal cytochromes and substrate-induced difference spectra. Biochemical pharmacology, 1970, Volume: 19, Issue:2 Topics: Aniline Compounds; Animals; Benzphetamine; Cyanides; Cytochromes; Drug Storage; Enzyme Induction; Heme; Hemoglobins; Hexobarbital; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methemoglobin; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrum Analysis; Time Factors	1970
Effect of drugs on heme synthesis in the liver. Metabolism: clinical and experimental, 1971, Volume: 20, Issue:2 Topics: Acyltransferases; Animals; Benzopyrenes; Cytochromes; Depression, Chemical; Glycine; Heme; Lead; Levulinic Acids; Liver; Lyases; Microsomes, Liver; Mitochondria; Oxidoreductases; Phenobarbital; Pyridines; Rats; Stimulation, Chemical; Succinates; Triazoles	1971
Effect of methylcholanthrene or phenobarbital pretreatment of rabbits and rats on the extinction coefficient for cytochrome P-450. Pharmacology, 1971, Volume: 5, Issue:1 Topics: Animals; Cytochromes; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Rats	1971
The nonerythropoietic component of early bilirubin. The Journal of clinical investigation, 1968, Volume: 47, Issue:6 Topics: Amides; Amino Acids; Animals; Bile Ducts; Biliary Fistula; Bilirubin; Carbon Isotopes; Catalase; Cycloheximide; Cytochromes; Erythropoiesis; Glycine; Heme; Infusions, Parenteral; Kidney; Lead Poisoning; Levulinic Acids; Male; Nephrectomy; Phenobarbital; Porphyrins; Protein Biosynthesis; Rats; Triazoles	1968
Effect of 1,4-dihydro-3,5-dicarbethoxycollidine on hepatic microsomal haem, cytochrome b5 and cytochrome P450 in rabbits and mice. Biochimica et biophysica acta, 1969, Jul-30, Volume: 184, Issue:2 Topics: Amides; Animals; Cytochromes; Depression, Chemical; Electron Transport; Heme; Liver; Mice; Microsomes; Phenobarbital; Picolines; Rabbits; Spectrophotometry; Stimulation, Chemical; Time Factors	1969
Early-labeled peak of bile pigment in man. Studies with glycine-14C and delta-aminolevulinic acid-3H. The New England journal of medicine, 1967, Dec-21, Volume: 277, Issue:25 Topics: Adolescent; Bile; Bilirubin; Carbon Isotopes; Glycine; Heme; Hemoglobinometry; Hemoglobins; Humans; Hyperbilirubinemia, Hereditary; Levulinic Acids; Male; Phenobarbital; Reticulocytes; Tritium	1967
1,1,1-Trichloropropene-2,3-oxide: an alternate mechanism for its inhibition of cytochrome P-450. Research communications in chemical pathology and pharmacology, 1982, Volume: 35, Issue:1 Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Ethers; Heme; Hydrocarbons, Chlorinated; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Trichloroepoxypropane	1982
Regulation of the synthesis of cytochrome P-450 in liver. Biochemical Society transactions, 1981, Volume: 9, Issue:6 Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Methylcholanthrene; Phenobarbital; Poly A; Protein Biosynthesis; Rats; RNA; RNA, Messenger	1981
Effect of carbon disulfide on superoxide anion production by rat liver microsomes. Experimental and molecular pathology, 1981, Volume: 34, Issue:3 Topics: Aniline Compounds; Animals; Carbon Disulfide; Cytochrome c Group; Heme; Male; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Potassium Cyanide; Rats; Superoxides	1981
7-Ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: regulation in cultured rat hepatocytes. Biochemical pharmacology, 1984, May-01, Volume: 33, Issue:9 Topics: 7-Alkoxycoumarin O-Dealkylase; Aminolevulinic Acid; Animals; Bucladesine; Cells, Cultured; Dexamethasone; Enzyme Induction; Glucagon; Heme; Insulin; Liver; Methylcholanthrene; Niacinamide; Oxygenases; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains	1984
Turnover of two drug-inducible forms of microsomal cytochrome P-450 in rat liver. Journal of biochemistry, 1983, Volume: 93, Issue:5 Topics: Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Half-Life; Heme; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains	1983
Activation of 3,4,3',4'-tetrachlorobiphenyl to protein-bound metabolites by rat liver microsomal cytochrome P-448-containing monooxygenase system. Toxicology and applied pharmacology, 1983, Sep-30, Volume: 70, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity	1983
Characterization of heme oxygenase activity in Leydig and Sertoli cells of the rat testes. Differential distribution of activity and response to cadmium. Biochemical pharmacology, 1984, May-01, Volume: 33, Issue:9 Topics: Age Factors; Animals; Bromobenzenes; Cadmium; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); Leydig Cells; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phenobarbital; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Sertoli Cells	1984
Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide. The Biochemical journal, 1984, Sep-01, Volume: 222, Issue:2 Topics: Acetamides; Allylisopropylacetamide; Animals; Apoenzymes; Cytochrome P-450 Enzyme System; Heme; Immunoelectrophoresis; In Vitro Techniques; Liver; Male; Phenobarbital; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrophotometry	1984
Heme metabolism in liver and spleen of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-treated rats. Biochemical pharmacology, 1984, Oct-15, Volume: 33, Issue:20 Topics: 5-Aminolevulinate Synthetase; Animals; Heme; Heme Oxygenase (Decyclizing); Liver; Lomustine; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Spleen	1984
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver. Archives of biochemistry and biophysics, 1983, Volume: 225, Issue:1 Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Triazoles	1983
Reversible transfer of heme between different molecular species of microsome-bound cytochrome P-450 in rat liver. Biochemical and biophysical research communications, 1983, Nov-15, Volume: 116, Issue:3 Topics: Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Heme; Isoenzymes; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats	1983
The effect of N-methylprotoporphyrin and succinyl-acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture. FEBS letters, 1983, Aug-08, Volume: 159, Issue:1-2 Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Ferrochelatase; Heme; Heptanoates; Heptanoic Acids; Liver; Phenobarbital; Porphyrins; Protoporphyrins	1983
The allylisopropylacetamide and novonal prosthetic heme adducts. Molecular pharmacology, 1984, Volume: 25, Issue:2 Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Magnetic Resonance Spectroscopy; Phenobarbital; Rats; Structure-Activity Relationship	1984
Chemical modification of cytochrome P-450 LM2. Characterization of tyrosine as axial heme iron ligand trans to thiolate. Biochimica et biophysica acta, 1984, May-31, Volume: 787, Issue:1 Topics: Acetylation; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Imidazoles; Kinetics; Ligands; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Tyrosine	1984
Effect of prolonged fasting on heme metabolism in the rat. Israel journal of medical sciences, 1984, Volume: 20, Issue:3 Topics: 5-Aminolevulinate Synthetase; Animals; Chromatography, Thin Layer; Fasting; Heme; Male; Phenobarbital; Porphobilinogen; Porphyrias; Rats; Rats, Inbred Strains	1984
The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes. The Journal of biological chemistry, 1983, Apr-10, Volume: 258, Issue:7 Topics: Acetylene; Alkenes; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Structure-Activity Relationship	1983
The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits. Biochemical and biophysical research communications, 1983, Mar-29, Volume: 111, Issue:3 Topics: Acetamides; Allylisopropylacetamide; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Microsomes, Liver; NADP; Phenobarbital; Rabbits	1983
Chiral orientation of prosthetic heme in the cytochrome P-450 active site. The Journal of biological chemistry, 1983, Jan-10, Volume: 258, Issue:1 Topics: Animals; Binding Sites; Circular Dichroism; Cytochrome P-450 Enzyme System; Heme; Isomerism; Phenobarbital; Porphyrins; Protein Binding; Protein Conformation; Protoporphyrins; Rats	1983
N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes. The Biochemical journal, 1983, May-01, Volume: 211, Issue:2 Topics: Alkylation; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; In Vitro Techniques; Isoenzymes; Liver; Male; Phenobarbital; Protoporphyrins; Pyridines; Rats; Rats, Inbred Strains	1983
Factors affecting haem degradation in rat brain. Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11 Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biotransformation; Brain; Female; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Lead; Liver; Phenobarbital; Rats	1980
Hepatic cytochrome P-450 and microsomal heme oxygenase in copper-deficient rats. The Journal of nutrition, 1981, Volume: 111, Issue:6 Topics: Animals; Cell Fractionation; Copper; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Iron; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Spleen	1981
[Activity of key enzymes of heme synthesis and degradation and contents of cytochromes b5 and P-450 in rat liver]. Biokhimiia (Moscow, Russia), 1981, Volume: 46, Issue:8 Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Kinetics; Liver; Mixed Function Oxygenases; Phenobarbital; Rats	1981
Control of delta-aminolaevulinate synthase and haem oxygenase in chronic-iron-overloaded rats. The Biochemical journal, 1981, Oct-15, Volume: 200, Issue:1 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1981
Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects. Ciba Foundation symposium, 1980, Volume: 76 Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Heme; Hemeproteins; Liver; Male; Microsomes, Liver; Mitochondria; Mixed Function Oxygenases; Phenobarbital; Rats	1980
Heme ligand replacement reactions of cytochrome P-450. Characterization of the bonding atom of the axial ligand trans to thiolate as oxygen. The Journal of biological chemistry, 1982, Mar-25, Volume: 257, Issue:6 Topics: Animals; Anions; Cytochrome P-450 Enzyme System; Heme; Microsomes, Liver; Phenobarbital; Potassium Cyanide; Protein Binding; Rabbits; Spectrophotometry	1982
The effect of inorganic lead on heptic biochemical and ultrastructural changes produced by phenobarbital. Toxicology letters, 1982, Volume: 10, Issue:1 Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Heme; Lead; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1982
Alkylation of the prosthetic heme in cytochrome P-450 during oxidative metabolism of the sedative-hypnotic ethchlorvynol. Journal of medicinal chemistry, 1982, Volume: 25, Issue:10 Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Ethchlorvynol; Heme; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains	1982
The turnover of cytochrome P450b. FEBS letters, 1982, Oct-18, Volume: 147, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Immunoelectrophoresis; Male; Mathematics; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1982
Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct. The Journal of biological chemistry, 1981, May-10, Volume: 256, Issue:9 Topics: Animals; Cytochrome P-450 Enzyme System; Ethylenes; Heme; Isomerism; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phenobarbital; Porphyrins; Protoporphyrins; Rats	1981
Effects of porphyrinogenic (porphyria-producing) agents on avian embryonic hepatic glutathione S-transferase activity. Biochemical and biophysical research communications, 1981, May-15, Volume: 100, Issue:1 Topics: Acetamides; Allylisopropylacetamide; Animals; Chick Embryo; Cyproterone; Cytochrome P-450 Enzyme System; Cytosol; Glutathione Transferase; Heme; Liver; Phenobarbital; Porphyrias	1981
Magnetic circular dichroism studies of cytochrome P-450cam. Characterization of axial ligands of ferric and ferrous low-spin complexes. Biochimica et biophysica acta, 1981, Oct-28, Volume: 670, Issue:3 Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Heme; Ligands; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Protein Conformation; Pseudomonas; Rabbits	1981
Cytochrome P-450 inactivation: structure of the prosthetic heme adduct with propyne. Biochemistry, 1981, Dec-08, Volume: 20, Issue:25 Topics: Alkynes; Animals; Cytochrome P-450 Enzyme Inhibitors; Heme; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Porphyrins; Rats; Rats, Inbred Strains; Spectrophotometry; Zinc	1981
Role of haem in the induction of cytochrome P-450 by phenobarbitone. Studies in chick embryos in ovo and in cultured chick embryo hepatocytes. The Biochemical journal, 1981, Aug-15, Volume: 198, Issue:2 Topics: 5-Aminolevulinate Synthetase; Acetates; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Liver; Phenobarbital	1981
Sex differences in biochemical manifestations of selenium deficiency in rat liver with special reference to heme metabolism. Biochemical pharmacology, 1980, Jan-01, Volume: 29, Issue:1 Topics: 5-Aminolevulinate Synthetase; Animals; Castration; Female; Heme; In Vitro Techniques; Liver; Male; Phenobarbital; Rats; Selenium; Sex Factors; Testosterone	1980
Inactivation of hepatic cytochrome P-450 by allenic substrates. Biochemical and biophysical research communications, 1980, May-30, Volume: 94, Issue:2 Topics: Alkadienes; Animals; Cytochrome P-450 Enzyme Inhibitors; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats	1980
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450. Biochemical and biophysical research communications, 1980, Aug-29, Volume: 95, Issue:4 Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats	1980
Structural and functional reconstitution of hepatic cytochrome P-450 in vivo. Reversal of allylisopropylacetamide-mediated destruction of the hemoprotein by exogenous heme. The Journal of biological chemistry, 1980, Nov-10, Volume: 255, Issue:21 Topics: Acetamides; Allylisopropylacetamide; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ethylmorphine-N-Demethylase; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats	1980
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs. The Biochemical journal, 1980, Sep-15, Volume: 190, Issue:3 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Microsomes, Liver; Phenobarbital; Porphyrias; Proadifen	1980
Inactivation of phenobarbital-inducible rabbit-liver microsomal cytochrome P-450 by allylisopropylacetamide: impact on electron transfer. Biochimica et biophysica acta, 1993, Apr-05, Volume: 1142, Issue:1-2 Topics: Allylisopropylacetamide; Amino Acids; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Electron Transport; Enzyme Induction; Heme; Microsomes, Liver; NAD; NADP; Phenobarbital; Proteins; Rabbits	1993
Identification and characterization of cytochrome P4501A1 amino acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue. Archives of biochemistry and biophysics, 1996, Jun-01, Volume: 330, Issue:1 Topics: 7-Alkoxycoumarin O-Dealkylase; Affinity Labels; Amino Acid Sequence; Animals; Azides; Benzoflavones; beta-Naphthoflavone; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Heme; Microsomes, Liver; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Photolysis; Rats; Tritium; Trypsin	1996
Induction of hepatic cytochrome P450 by phenobarbitone in rhesus monkey (Macaca mulatta). Drug and chemical toxicology, 1996, Volume: 19, Issue:1-2 Topics: Aminopyrine N-Demethylase; Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Cytochromes b5; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Heme; Hypnotics and Sedatives; Injections, Intraperitoneal; Macaca mulatta; Male; Microsomes, Liver; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Phenobarbital	1996
Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins. Chemical research in toxicology, 1996, Volume: 9, Issue:4 Topics: Animals; Anticoagulants; Anticonvulsants; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A1; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Furocoumarins; Heme; Humans; Hypnotics and Sedatives; Methylcholanthrene; Mice; Mice, Inbred SENCAR; Microsomes, Liver; Phenobarbital; Plant Extracts; Radioligand Assay	1996
Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytes. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:1 Topics: Animals; Arginine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Griseofulvin; Heme; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Nitrobenzoates; Phenobarbital; RNA, Messenger	1997
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver. The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorides; Cobalt; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferric Compounds; Gene Expression Regulation, Enzymologic; Heme; Hemin; Liver; Molecular Weight; Nuclear Proteins; Phenobarbital; Protoporphyrins; Rats; RNA, Messenger; Steroid Hydroxylases; Transcription, Genetic	1997
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation. General pharmacology, 1997, Volume: 28, Issue:4 Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Hypnotics and Sedatives; Isoflurane; Liver; Male; Mice; Phenobarbital; Porphobilinogen; Porphyrins	1997
Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:4 Topics: Alkenes; Anaerobiosis; Animals; Biotransformation; Carbon Monoxide; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cyclic N-Oxides; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione; Heme; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Pyridines; Rats; Rats, Wistar	1996
Glucose inhibits phenobarbital-induced delta-aminolevulinate synthase expression in normal but not in diabetic rat hepatocytes. Biochemistry and cell biology = Biochimie et biologie cellulaire, 1996, Volume: 74, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 5-Aminolevulinate Synthetase; Adenylyl Cyclases; Animals; Blood Glucose; Bucladesine; Cyclic AMP; Diabetes Mellitus, Experimental; Enzyme Induction; Enzyme Inhibitors; Glucose; Heme; Immunity, Innate; Liver; Male; Phenobarbital; Porphyrias; Rats; Second Messenger Systems; Streptozocin	1996
Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes. Toxicology and applied pharmacology, 1998, Volume: 150, Issue:2 Topics: Animals; Arsenites; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; RNA, Messenger; Sodium Compounds	1998
Heme and acute inflammation role in vivo of heme in the hepatic expression of positive acute-phase reactants in rats. European journal of biochemistry, 1999, Volume: 261, Issue:1 Topics: Acute-Phase Proteins; alpha-Macroglobulins; Animals; Base Sequence; Cytochrome P-450 Enzyme System; DNA Primers; Female; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Inflammation; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger	1999
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension. Molecular pharmacology, 1999, Volume: 56, Issue:1 Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine	1999
Role of interleukin-1beta in the modulations of cytochrome P450 and heme metabolism in rat liver. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 1999, Volume: 19, Issue:6 Topics: 5-Aminolevulinate Synthetase; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); Humans; Interleukin-1; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley	1999
Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC). Biochimica et biophysica acta, 1999, Nov-16, Volume: 1472, Issue:3 Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Chick Embryo; Chickens; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutethimide; Heme; Heptanoates; Liver; Liver Neoplasms; Phenobarbital; RNA, Messenger; Tumor Cells, Cultured	1999
Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital. European journal of biochemistry, 2000, Volume: 267, Issue:24 Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Hydroxymethylbilane Synthase; Liver; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Transcriptional Activation	2000
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria. Hepatology (Baltimore, Md.), 2001, Volume: 33, Issue:5 Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug Combinations; Female; Heme; Heme Oxygenase (Decyclizing); Injections, Intraperitoneal; Liver; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Phenobarbital; Porphyria, Acute Intermittent; Porphyrias, Hepatic; Reference Values; RNA, Messenger	2001
Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochemical pharmacology, 2003, Sep-15, Volume: 66, Issue:6 Topics: 5-Aminolevulinate Synthetase; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hepatocytes; Male; Phenobarbital; Protective Agents; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; RNA, Messenger	2003
Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase? The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1 Topics: Aminolevulinic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2B1; eIF-2 Kinase; Enzyme Induction; Heat-Shock Proteins; Heme; Hepatocytes; Molecular Chaperones; Peptide Elongation Factor 2; Phenobarbital; Phosphorylation; Proteins; Protoporphyrins; Pyrimethamine; Rats; Steroid Hydroxylases; Transcriptional Activation	2005
Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1 Topics: Animals; Apoproteins; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Crystallization; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Glutathione; Heme; Hormone Antagonists; Humans; In Vitro Techniques; Isoenzymes; Microsomes, Liver; Mifepristone; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry	2009
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers. Free radical research, 2010, Volume: 44, Issue:4 Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Catalase; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Disease Models, Animal; Enzyme Induction; Glutathione; Heme; Lipid Peroxidation; Liver; Liver Diseases; Male; Membrane Proteins; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidative Stress; Phenobarbital; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Warm Ischemia	2010
[Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment]. La Tunisie medicale, 2009, Volume: 87, Issue:9 Topics: Acute Disease; Adolescent; Arginine; Electromyography; Famotidine; Female; Heme; Heme Oxygenase (Decyclizing); Humans; Nifedipine; Peripheral Nervous System Diseases; Phenobarbital; Porphyrias; Porphyrinogens; Time Factors	2009
A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. Disease models & mechanisms, 2017, 08-01, Volume: 10, Issue:8 Topics: Anemia, Hypochromic; Animals; Base Sequence; Biosynthetic Pathways; Coproporphyria, Hereditary; Coproporphyrinogen Oxidase; Disease Models, Animal; Ethylnitrosourea; Fasting; Feces; Female; Heme; Male; Mice, Mutant Strains; Mutagenesis; Mutation; Phenobarbital; Phenotype; Pregnancy	2017
Sex differences in vascular reactivity in mesenteric arteries from a mouse model of acute intermittent porphyria. Molecular genetics and metabolism, 2019, Volume: 128, Issue:3 Topics: Acetylcholine; Animals; Disease Models, Animal; Female; Heme; Hydroxymethylbilane Synthase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Phenobarbital; Phenylephrine; Porphyria, Acute Intermittent; Sex Factors; Vasodilation	2019
Assessment of porphyrogenicity of drugs and chemicals in selected hepatic cell culture models through a fluorescence-based screening assay. Pharmacology research & perspectives, 2022, Volume: 10, Issue:3 Topics: Cell Culture Techniques; Heme; Hepatocytes; Humans; Liver; Norgestrel; Phenobarbital; Phenytoin; Porphobilinogen Synthase; Porphyrias, Hepatic; Valproic Acid	2022