phenobarbital has been researched along with formaldehyde in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (86.49) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Furukawa, T; Karashima, D; Shigematsu, A; Takahashi, S | 1 |
| Castro, JA; Diaz Gomez, MI; Godoy, HM | 1 |
| Andersson, B; Jones, DP; Orrenius, S; Thor, H | 1 |
| Campbell, RL; Hettrick, JM; Nigro, ND; Suppnick, JD | 1 |
| Acheampont-Mensah, D; Feuer, G | 1 |
| Iley, J; Ruecroft, G | 1 |
| Cederbaum, AI; Winters, DK | 1 |
| Cinicola, DP; Esposito, FM; Winek, CL | 1 |
| Baba, T; Oguri, K; Yamada, H; Yoshimura, H | 1 |
| Bloom, SE; Lorr, NA | 1 |
| Black, KA; Coffman, BL; Dannan, GA; Green, MD; Guengerich, FP; Tephly, TR | 1 |
| Antoni, F; Bánhegyi, G; Garzó, T; Mandl, J | 1 |
| Gangolli, S; Wright, M | 1 |
| Edds, GT; Himes, JA; Shetty, SN | 1 |
| Bickel, MH; Willi, P | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| Heni, N; Remmer, H | 1 |
| Fouts, JR; Gram, TE; Wilson, JT | 1 |
| Coon, MJ; Lu, AY; Strobel, HW | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 1 |
| Estabrook, RW; Franklin, MR | 1 |
| Estabrook, RW; Hildebrandt, A | 1 |
| Nebert, DW; Poland, AP | 1 |
| Van Dyke, RA; Wood, CL | 1 |
| Day, PA; McLean, AE | 1 |
| Bürki, K; Pfenninger, M; Schindler, R | 1 |
| Darby, FJ | 1 |
| Beal, DD; Bryan, GT; Ramirez, G; Skibba, JL | 1 |
| Remmer, H | 1 |
| Fuller, GC; Lal, H; Olshan, AM | 1 |
| Mannering, GJ; Sladek, NE | 1 |
| Creighton, JM; Marks, GS | 1 |
| Hermann, G; Ruf, HH; Sakurai, H; Ullrich, V | 1 |
| SCHENKER, S; WARREN, KS | 1 |
| SYAM, NK | 1 |
| Cha, DS; Jeon, H; Park, HJ | 1 |
37 other study(ies) available for phenobarbital and formaldehyde
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Formaldehyde formation as a metabolite of methoxyflurane.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Formaldehyde; Haplorhini; Male; Methoxyflurane; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Rabbits; Rats | 1977 |
Mechanism of dimethylnitrosamine metabolism and activation in rats.
Topics: Animals; Biotransformation; Carbon Dioxide; Cobalt; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrosamines; Nucleic Acids; Phenobarbital; Proadifen; Protein Binding; Rats; Subcellular Fractions | 1978 |
Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.
Topics: Aldehyde Oxidoreductases; Animals; Catalase; Cytochrome P-450 Enzyme System; Formaldehyde; Formates; Glutathione Peroxidase; Hydrogen Peroxide; In Vitro Techniques; Kinetics; Liver; Male; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Peroxidases; Phenobarbital; Rats | 1978 |
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Benzoflavones; Biotransformation; Chlorides; Cobalt; Diet; Disulfiram; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats | 1978 |
Effect of phenobarbital on methyl transfer between methylated drugs and hepatic microsomal phospholipids.
Topics: Animals; Formaldehyde; In Vitro Techniques; Male; Methionine; Methylation; Microsomes, Liver; Nicotine; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Rats | 1975 |
Mechanism of the microsomal demethylation of 1-aryl-3,3-dimethyltriazenes.
Topics: Animals; Dealkylation; Formaldehyde; Free Radicals; Kinetics; Male; Microsomes, Liver; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Stimulation, Chemical; Triazines | 1990 |
Oxidation of glycerol to formaldehyde by rat liver microsomes. Effects of cytochrome P-450 inducing agents.
Topics: Acetone; Aldehyde Oxidoreductases; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fomepizole; Formaldehyde; Glycerol; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1990 |
The stability of several compounds in formalin fixed tissues and formalin-blood solutions.
Topics: Carbon Monoxide; Carboxyhemoglobin; Cyanides; Desipramine; Diazepam; Drug Stability; Embalming; Fixatives; Formaldehyde; Humans; Liver; Phenobarbital; Phenytoin; Postmortem Changes | 1990 |
Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Formaldehyde; Hydroxylation; Isoenzymes; Male; Methamphetamine; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Ontogeny of the chicken cytochrome P-450 enzyme system. Expression and development of responsiveness to phenobarbital induction.
Topics: Aminopyrine N-Demethylase; Animals; Chick Embryo; Chickens; Cytochrome P-450 Enzyme System; Enzyme Induction; Formaldehyde; Liver; Microsomes, Liver; Phenobarbital | 1987 |
Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins.
Topics: Aminopyrine; Animals; Apoproteins; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Formaldehyde; Formates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Testosterone | 1986 |
Interrelationship between aminopyrine oxidation and gluconeogenesis in hepatocytes prepared from fructose-pretreated mice.
Topics: Aminopyrine; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Formaldehyde; Fructose; Gluconeogenesis; Hexobarbital; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oxidation-Reduction; Phenobarbital | 1987 |
The histochemical demonstration of aniline hydroxylase activity in rat liver.
Topics: Acetone; Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Diazonium Compounds; Ethanol; Female; Formaldehyde; Histocytochemistry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrogen; Phenobarbital; Phenols; Rats; Staining and Labeling; Time Factors | 1971 |
Enzyme induction in sheep: effects of phenobarbital on in vivo and in vitro drug metabolism.
Topics: Anesthesia; Aniline Compounds; Animals; Antipyrine; Cytochromes; Dicumarol; Enzyme Induction; Female; Formaldehyde; Half-Life; Hexobarbital; Metabolic Clearance Rate; Microsomes, Liver; Pentobarbital; Phenobarbital; Phenols; Proteins; Sheep; Sleep; Sulfobromophthalein; Time Factors | 1972 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.
Topics: Acetates; Aniline Compounds; Animals; Calcium; Depression, Chemical; Edetic Acid; Formaldehyde; Glycols; Kinetics; Magnesium; Male; Methylation; Microsomes, Liver; NADP; Niacinamide; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Proadifen; Rats; Species Specificity; Stimulation, Chemical; Sulfhydryl Reagents; Swine | 1973 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
[Effect of carbon tetrachloride on endoplasmic enzymes in rat liver].
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cholinesterases; Cytochromes; Endoplasmic Reticulum; Formaldehyde; Glucose-6-Phosphatase; Hexobarbital; Male; Membranes; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrophotometry | 1971 |
Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit.
Topics: Aminopyrine; Animals; Antipyrine; Chromatography, Thin Layer; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microsomes; NADP; Oxygen; Phenobarbital; Rabbits; Rats | 1968 |
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.
Topics: Aminopyrine; Animals; Appetite Depressants; Benzphetamine; Cytochromes; Depression, Chemical; Ethers; Fatty Acids; Formaldehyde; Hexobarbital; Lipid Metabolism; Liver; Microsomes; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenethylamines; Phenobarbital; Propylamines; Rabbits; Spectrophotometry | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.
Topics: Animals; Carbon Monoxide; Chlorides; Cytochromes; Dealkylation; Electron Transport; Fasting; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Magnesium; Male; Mercury; Microsomes, Liver; Morphinans; NAD; NADP; Organomercury Compounds; Osmolar Concentration; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Phenobarbital; Phosphates; Polarography; Potassium Chloride; Rats; Spectrophotometry; Time Factors; Tromethamine; Ultracentrifugation | 1971 |
Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions.
Topics: Aldehydes; Anaerobiosis; Animals; Chlorides; Colorimetry; Cytochromes; Electron Transport; Formaldehyde; Isocitrate Dehydrogenase; Kinetics; Lipid Metabolism; Magnesium; Male; Malonates; Microsomes, Liver; Models, Biological; Morphinans; Myocardium; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Spectrophotometry; Tromethamine | 1971 |
A sensitive radiometric assay of aminopyrine N-demethylation.
Topics: Acetamides; Aminopyrine N-Demethylase; Animals; Carbon Isotopes; Chick Embryo; Colorimetry; Cytochrome P-450 Enzyme System; Dealkylation; Fetus; Formaldehyde; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kidney; Kinetics; Liver; Lung; Male; Methods; Methylcholanthrene; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Proteins; Rats | 1973 |
Metabolism of methoxyflurane: release of inorganic fluoride in human and rat hepatic microsomes.
Topics: Animals; Biotransformation; Chlorine; Enzyme Induction; Fluorides; Formaldehyde; Humans; Hydrogen-Ion Concentration; Male; Methoxyflurane; Methylcholanthrene; Microsomes, Liver; Nitrous Oxide; Phenobarbital; Rats; Tetracycline | 1973 |
The use of new methods to measure: the effect of diet and inducers of microsomal enzyme synthesis on cytochrome P-450 in liver homogenates, and on metabolism of dimethyl nitrosamine.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dealkylation; Diet; Dietary Fats; Dietary Proteins; Dimethylamines; Enzyme Induction; Formaldehyde; In Vitro Techniques; Kinetics; Liver; Methods; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Phenobarbital; Rats; Stimulation, Chemical | 1974 |
Studies on liver regeneration. II. Effects of phenobarbital on the onset and pattern of rat liver regeneration following partial hepatectomy.
Topics: Animals; Deoxyuridine; DNA; Formaldehyde; Hepatectomy; Histological Techniques; Iodine Isotopes; Liver; Liver Regeneration; Male; Mitosis; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1971 |
Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.
Topics: Aniline Compounds; Animals; Animals, Newborn; Carbon Isotopes; Chlorpromazine; Cytochromes; Female; Formaldehyde; Hydroxylation; Lactation; Liver; Milk; Morphinans; Oxidoreductases; Pentobarbital; Phenobarbital; Pregnancy; Rats | 1971 |
N-demethylation the antineoplastic agent4(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide by rats and man.
Topics: Animals; Antineoplastic Agents; Carbon Dioxide; Carbon Isotopes; Formaldehyde; Humans; Imidazoles; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Prochlorperazine; Protein Biosynthesis; Rats | 1970 |
Induction of microsomal hydroxylase: involvement of a second factor besides cytochrome P-450.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochromes; DDT; Enzyme Induction; Female; Formaldehyde; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1968 |
The stimulatory effect of phenobarbital on the N-demethylation of P-chloro-N-methylaniline.
Topics: Aminopyrine; Aniline Compounds; Animals; Enzyme Induction; Female; Formaldehyde; Liver; Male; Methods; Methylation; Microsomes; Phenobarbital; Rats | 1969 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
Drug-induced porphytin biosynthesis. I. The effect of porphyria-inducing drugs on N-demethylase activity of chick embryo liver.
Topics: Amides; Aminopyrine; Animals; Chemical Phenomena; Chemistry; Chick Embryo; Formaldehyde; In Vitro Techniques; Liver; Microsomes; Oxidoreductases; Phenobarbital; Porphyrias; Porphyrins; Pyridines | 1969 |
The interaction of aliphatic nitro compounds with the liver microsomal monooxygenase system.
Topics: Animals; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrites; Nitro Compounds; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1980 |
DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.
Topics: Acetazolamide; Ammonia; Ammonium Chloride; Arginine; Chlorothiazide; Cortisone; Formaldehyde; Glutamates; Hepatic Encephalopathy; Hydrogen-Ion Concentration; Iproniazid; Mice; Morphine; Paraldehyde; Pentobarbital; Phenobarbital; Research; Toxicology; Tryptophan | 1963 |
A CASE OF HYDATID CYST OF THE LIVER SUCCESSFULLY REMEDIED.
Topics: Child; Chlorpromazine; Dogs; Echinococcosis; Formaldehyde; Humans; India; Liver Diseases; Liver Diseases, Parasitic; Penicillins; Phenobarbital; Streptomycin; Surgical Procedures, Operative | 1964 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Hypnotics and Sedatives; Indomethacin; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Phenobarbital; Plant Extracts; Plants, Medicinal; Reaction Time; Sleep; Time Factors; Tramadol | 2011 |