phenobarbital and fluorouracil

phenobarbital has been researched along with fluorouracil in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (30.77)	29.6817
2010's	5 (19.23)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Einhorn, R; Franki, N; Hays, RM; Levine, SD	1
Fujimoto, S; Ishigami, H; Itoh, K; Kimura, K; Minami, T; Miyazaki, M	1
Belitskiĭ, GA; Bukhman, VM; Konopleva, IA	1
Hirata, M; Kamata, S; Tonda, K	1
Ambre, JJ; Fischer, LJ	1
Spector, RG	1
Fujimoto, S; Hosaka, T; Karaki, S; Kawanomoto, S; Kitsukawa, Y; Miyazaki, M; Okui, K	1
Hirata, M; Tonda, K	1
Fujimoto, S; Gambe, K; Hikosaka, T; Hosaka, T; Itoh, K; Karaki, S; Kawanomoto, S; Tazawa, T	1
Hobara, N; Watanabe, A	1
Belitsky, GA; Bukhman, VM; Konopleva, IA	1
Bolanowska, W; Gessner, T	1
BRESNICK, E; YANG, HY	1
Amaddeo, P; Barbaglio, A; Faldi, F; Fontana, S; Ghilardi, R; Pericotti, S	1
Hori, S; Miki, A; Satoh, H; Sawada, Y; Togawa, T; Tsuda, A	1
Chow, LW; Glück, S; Im, SA; Lee, MH; Ng, TY; Toi, M; Tung, SY; Yip, AY	1

Reviews

1 review(s) available for phenobarbital and fluorouracil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for phenobarbital and fluorouracil

Article	Year
Clinical evaluation of prolonged chemotherapy combined with induction of hepatic drug-metabolizing enzymes as an adjuvant for treating patients with gastric cancer. The Japanese journal of surgery, 1983, Volume: 13, Issue:6 Topics: Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Enzyme Induction; Fluorouracil; Glutathione; Humans; Microsomes, Liver; Phenobarbital; Random Allocation; Stomach Neoplasms; Tegafur; Time Factors	1983
Concurrent celecoxib with 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel for stages II - III invasive breast cancer: the OOTR-N001 study. Expert opinion on investigational drugs, 2013, Volume: 22, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Celecoxib; Cyclophosphamide; Disease-Free Survival; Docetaxel; Epirubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Phenobarbital; Prospective Studies; Pyrazoles; Receptor, ErbB-2; Sulfonamides; Taxoids	2013

Article

Year

Clinical evaluation of prolonged chemotherapy combined with induction of hepatic drug-metabolizing enzymes as an adjuvant for treating patients with gastric cancer.

The Japanese journal of surgery, 1983, Volume: 13, Issue:6

Topics: Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Enzyme Induction; Fluorouracil; Glutathione; Humans; Microsomes, Liver; Phenobarbital; Random Allocation; Stomach Neoplasms; Tegafur; Time Factors

1983

Concurrent celecoxib with 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel for stages II - III invasive breast cancer: the OOTR-N001 study.

Expert opinion on investigational drugs, 2013, Volume: 22, Issue:3

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Celecoxib; Cyclophosphamide; Disease-Free Survival; Docetaxel; Epirubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Phenobarbital; Prospective Studies; Pyrazoles; Receptor, ErbB-2; Sulfonamides; Taxoids

2013

Other Studies

23 other study(ies) available for phenobarbital and fluorouracil

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Vasopressin-stimulated movement of drugs and uric acid across the toad urinary bladder. Kidney international, 1976, Volume: 9, Issue:1 Topics: Adenine; Animals; Anti-Bacterial Agents; Anura; Butanols; Cell Membrane Permeability; Cyclic AMP; Cyclohexanones; Female; Fluorouracil; Glutethimide; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phloretin; Stimulation, Chemical; Uric Acid; Urinary Bladder; Vasopressins	1976
Metabolism of 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil in mice. Journal of the National Cancer Institute, 1979, Volume: 63, Issue:2 Topics: Animals; Fluorouracil; Half-Life; Kidney; Liver; Male; Mice; Phenobarbital; Tegafur	1979
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase]. Biulleten' eksperimental'noi biologii i meditsiny, 1979, Volume: 88, Issue:10 Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Methylcholanthrene; Mice; Microsomes; Oxidoreductases; Phenobarbital; Premedication; Proadifen; Rauscher Virus; Spleen; Tegafur	1979
Metabolism of 1-phthalidyl 5-fluorouracil in rat liver and enzyme induction by phenobarbital. Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:6 Topics: Aldehyde Oxidoreductases; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Enzyme Induction; Fluorouracil; Hydrolases; In Vitro Techniques; Liver; Male; Methylcholanthrene; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains; Sarcoma, Experimental	1987
The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats. The Journal of laboratory and clinical medicine, 1971, Volume: 78, Issue:3 Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, Ion Exchange; Drug Interactions; Fluorine; Fluorouracil; Male; Phenobarbital; Prednisolone; Propionates; Rats; Urea	1971
Influence of folic acid on noradrenaline stimulation of rat brain synaptosomes. British journal of pharmacology, 1971, Volume: 43, Issue:2 Topics: Animals; Brain; Epinephrine; Fluorouracil; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Nerve Endings; Norepinephrine; Oxygen Consumption; Phenobarbital; Rats; Synaptic Vesicles; Synaptosomes	1971
Drug interactions in biotransformation of 1-phthalidyl 5-fluorouracil to 5-fluorouracil in rat liver. Chemico-biological interactions, 1984, Volume: 52, Issue:2 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorouracil; Hydrolases; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1984
Intensified cancer themotherapy by induction of hepatic drug-metabolizing enzymes as a trial for the treatment for stomach cancer. The Japanese journal of surgery, 1980, Volume: 10, Issue:1 Topics: Drug Therapy, Combination; Enzyme Induction; Fluorouracil; Humans; Liver; Mitomycins; Phenobarbital; Stomach Neoplasms; Tegafur	1980
Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride. Pharmacology, 1980, Volume: 21, Issue:5 Topics: Animals; Carbon Tetrachloride; Diclofenac; Female; Fluorouracil; Indomethacin; Microsomes, Liver; Phenobarbital; Phenylacetates; Rats; Tegafur; Time Factors	1980
Changes in toxic and antitumor properties of ftorafur by induction or inhibition of the microsomal enzymes activity. Cancer chemotherapy and pharmacology, 1981, Volume: 6, Issue:2 Topics: Animals; Antineoplastic Agents; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Fluorouracil; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Tegafur	1981
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats. Biochemical pharmacology, 1980, Apr-15, Volume: 29, Issue:8 Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; Inactivation, Metabolic; Liver Neoplasms, Experimental; Male; Neoplasms, Experimental; Phenobarbital; Prednisolone; Prednisone; Rats; Rats, Inbred ACI	1980
THE INFLUENCE OF PHENOBARBITAL ADMINISTRATION UPON THE "SOLUBLE" NADP-REQUIRING ENZYMES IN LIVER. Biochemical pharmacology, 1964, Volume: 13 Topics: Aminopyrine; Benzopyrenes; Citrates; Diphenhydramine; Ethionine; Fluorouracil; Gluconates; Hexosephosphates; Isocitrate Dehydrogenase; Liver; Mercaptopurine; Methylcholanthrene; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylalanine; Rats; Research; Uracil	1964
Male breast cancer with mandibular metastasis. A case report. Minerva stomatologica, 2007, Volume: 56, Issue:4 Topics: Aged; Androstadienes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Cortisone; Cyclophosphamide; Diphosphonates; Docetaxel; Fatal Outcome; Fluorouracil; Furosemide; Humans; Imidazoles; Liver Neoplasms; Male; Mandibular Neoplasms; Mastectomy, Modified Radical; Methotrexate; Omeprazole; Osteolysis; Phenobarbital; Taxoids; Toremifene; Vinblastine; Vinorelbine; Zoledronic Acid	2007
Sequential interaction of phenytoin and phenobarbital with fluorouracil. International journal of clinical pharmacology and therapeutics, 2012, Volume: 50, Issue:12 Topics: Drug Interactions; Fluorouracil; Humans; Male; Middle Aged; Phenobarbital; Phenytoin	2012