phenobarbital has been researched along with epidermal growth factor in 37 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 11 (29.73) | 18.7374 |
1990's | 16 (43.24) | 18.2507 |
2000's | 4 (10.81) | 29.6817 |
2010's | 6 (16.22) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Marx, JL | 1 |
Manjeshwar, S; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
Armato, U; Carcereri dePrati, A; Menapace, L; Menegazzi, M; Miwa, M; Ribecco, M; Suzuki, H; Testolin, L | 1 |
Erber, E; Parzefall, W; Schulte-Hermann, R; Sedivy, R | 1 |
Michalopoulos, GK; Tsai, WH | 1 |
Shi, YE; Yager, JD | 1 |
Brockenbrough, JS; Jirtle, RL; Li, CX; Meyer, SA | 1 |
Jirtle, RL; Meyer, SA | 3 |
Bock, KW; Kobusch, AB | 1 |
d'Arville, CN; Kloppel, TM; Le, M; Simon, FR | 1 |
Gibbs, TA; Jirtle, RL; Meyer, SA | 1 |
Betschart, JM; Gupta, C; Hattori, A; Shinozuka, H; Virji, MA | 1 |
Eckl, PM; Jirtle, RL; Meyer, SA; Whitcombe, WR | 1 |
Pitot, HC; Sawada, N; Staecker, JL | 1 |
Grisham, JW; Smith, JD; Tsao, MS | 1 |
Andreis, PG; Armato, U; Romano, F | 2 |
Kayano, T; Kitagawa, T; Mikami, K; Sugano, H; Watanabe, R | 1 |
Aubrecht, J; Becker-Rabbenstein, V; Hirsch-Ernst, KI; Höhne, MW; Kahl, GF; Taniguchi, H | 1 |
Lindroos, P; Michalopoulos, GK | 1 |
Oberhammer, FA; Qin, HM | 1 |
Aubrecht, J; Höhne, MW; Kahl, GF | 1 |
DeAngelo, AB; Tsai, WH | 1 |
Chipman, JK; Fletcher, K; Orton, TC; Strain, AJ | 1 |
Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T | 1 |
Chipman, JK; Fletcher, K; Lord, PG; Orton, TC; Strain, AJ | 1 |
Fleig, WE; Jäger, D; Köhler, C; Kostrubsky, VE; Lehmann, T; May, U; Michalopoulos, GK; Runge, D; Runge, DM; Stolz, DB; Strom, SC | 1 |
Chipman, JK; Hodges, NJ; Orton, TC; Strain, AJ | 1 |
Bauer, D; Hirsch-Ernst, KI; Kahl, GF; Wolfram, N | 1 |
Bachleda, P; Dvorák, Z; Vrzal, R | 1 |
Moore, R; Mutoh, S; Negishi, M; Pedersen, L; Perera, L; Sobhany, M; Sueyoshi, T | 1 |
Andersen, ME; Cowie, DE; Deisenroth, C; LeCluyse, E; Peffer, RC; Soldatow, V; Trask, OJ | 1 |
Briolotti, P; Daujat-Chavanieu, M; de Boussac, H; Duret, C; Fabre, JM; Gerbal-Chaloin, S; Gondeau, C; Herrero, A; Maurel, P; Ramos, J; Römer, M; Templin, M; Treindl, F | 1 |
Chatham, LR; Elcombe, BM; Elcombe, CR; Haines, C; Higgins, LG; Lake, BG; Vardy, A | 1 |
Akita, H; Azuma, I; Chiba, K; Furihata, T; Kobayashi, K; Yokobori, K | 1 |
37 other study(ies) available for phenobarbital and epidermal growth factor
Article | Year |
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Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Growth Factor; Humans; Neoplasms; Ornithine Decarboxylase; Phenobarbital; Plasminogen Activators; Receptors, Drug; Saccharin; Smoking; Tetradecanoylphorbol Acetate | 1978 |
Inhibition of DNA synthesis by phenobarbital in primary cultures of hepatocytes from normal rat liver and from hepatic nodules.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Diseases; Male; Orotic Acid; Phenobarbital; Rats; Rats, Inbred F344; Transforming Growth Factor alpha | 1992 |
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethylnitrosamine; DNA Replication; Epidermal Growth Factor; Female; Kinetics; Liver; Liver Neoplasms; Maternal-Fetal Exchange; Mutagenesis; Phenobarbital; Poly(ADP-ribose) Polymerases; Precancerous Conditions; Pregnancy; Rats; Rats, Inbred Strains; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic | 1992 |
Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters.
Topics: Adult; Aged; Autoradiography; Carcinogens; Cyproterone; Cyproterone Acetate; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Gene Expression Regulation; Hexachlorocyclohexane; Humans; In Vitro Techniques; Liver; Male; Middle Aged; Nafenopin; Phenobarbital; Recombinant Proteins; Rifampin | 1991 |
Responsiveness of hepatocytes to epidermal growth factor, transforming growth factor-beta and norepinephrine during treatment with xenobiotic hepatic tumor promoters.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Replication; Epidermal Growth Factor; Hexachlorocyclohexane; Kinetics; Liver; Male; Norepinephrine; Phenobarbital; Rats; Rats, Inbred F344; Transforming Growth Factor beta | 1991 |
Stimulation of hepatocyte DNA synthesis by ethinyl estradiol.
Topics: Animals; Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Ethinyl Estradiol; Female; Growth Substances; Hepatocyte Growth Factor; Kinetics; Liver; Liver Regeneration; Phenobarbital; Rats; Rats, Inbred Strains; Thymidine | 1991 |
Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats.
Topics: Animals; Cell Compartmentation; Cell Membrane; Cytosol; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Liver; Male; Phenobarbital; Phorbol Esters; Protein Kinase C; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1991 |
Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
Topics: Animals; Binding, Competitive; Cell Transformation, Neoplastic; Diethylnitrosamine; Epidermal Growth Factor; Liver; Liver Neoplasms, Experimental; Phenobarbital; Protein Kinase C; Rats; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 1991 |
Zinc increases EGF-stimulated DNA synthesis in primary mouse hepatocytes. Studies in tumor promoter-treated cell cultures.
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; Chlorides; Culture Media; DNA; Drug Interactions; Epidermal Growth Factor; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Polychlorinated Biphenyls; Tetradecanoylphorbol Acetate; Zinc; Zinc Compounds | 1990 |
Alterations in the functional expression of receptors on cirrhotic rat hepatocytes.
Topics: Animals; Asialoglycoprotein Receptor; Carbon Tetrachloride Poisoning; Epidermal Growth Factor; ErbB Receptors; Insulin; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Receptor, Insulin; Receptors, Cell Surface; Receptors, Immunologic | 1989 |
Phenobarbital decreases hepatocyte EGF receptor expression independent of protein kinase C activation.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Liver; Phenobarbital; Protein Kinase C; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1989 |
Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.
Topics: Animals; Binding, Competitive; Carcinogens; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Kinetics; Liver; Phenobarbital; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1989 |
Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.
Topics: Animals; Choline Deficiency; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Temperature | 1988 |
Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation.
Topics: Animals; Calcium; Cell Division; Epidermal Growth Factor; ErbB Receptors; Female; Liver; Phenobarbital; Rats; Rats, Inbred F344 | 1988 |
Effects of tumor-promoting agents 12-O-tetradecanoylphorbol-13-acetate and phenobarbital on DNA synthesis of rat hepatocytes in primary culture.
Topics: Animals; Cell Count; Cell Cycle; Cells, Cultured; DNA; Epidermal Growth Factor; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thymine Nucleotides; Time Factors | 1987 |
The modulation of growth of normal rat liver epithelial cells in calcium-poor medium by epidermal growth factor, phenobarbital, phorbol ester, and retinoic acid.
Topics: Animals; Calcium; Cell Division; Cell Line; Cell Survival; Culture Media; Epidermal Growth Factor; Epithelial Cells; Epithelium; Liver; Phenobarbital; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
The stimulation by the tumour promoters 12-O-tetradecanoylphorbol-13-acetate and phenobarbital of the growth of primary neonatal rat hepatocytes.
Topics: Animals; Calmodulin; Carcinogens; Cell Division; Egtazic Acid; Epidermal Growth Factor; Female; Imidazoles; In Vitro Techniques; Lanthanum; Liver; Male; Phenobarbital; Phorbols; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate | 1985 |
Promotion of hepatocarcinogenesis in vivo and in vitro.
Topics: Animals; Epidermal Growth Factor; gamma-Glutamyltransferase; In Vitro Techniques; Liver; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Mice; Phenobarbital; Rats; Time Factors | 1983 |
Exogenous Cu,Zn-superoxide dismutase suppresses the stimulation of neonatal rat hepatocytes' growth by tumor promoters.
Topics: Animals; Animals, Newborn; Antioxidants; Carcinogens; Cells, Cultured; Copper; DNA; Epidermal Growth Factor; Female; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Zinc | 1984 |
Induction of cytochrome P-4502B1-related mouse cytochrome P-450 and regulation of its expression by epidermal growth factor/transforming growth factor alpha in primary hepatocyte culture.
Topics: Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Liver; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Steroid Hydroxylases; Time Factors; Transforming Growth Factor alpha | 1995 |
Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels.
Topics: Animals; Cell Division; Cells, Cultured; Clofibric Acid; Collagen; DNA; Drug Interactions; Epidermal Growth Factor; Fibric Acids; Fibroblast Growth Factor 1; Hepatocyte Growth Factor; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1993 |
Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-beta 1.
Topics: Apoptosis; Carcinogens; Cell Differentiation; Cells, Cultured; Cyproterone Acetate; Epidermal Growth Factor; In Vitro Techniques; Liver; Nafenopin; Phenobarbital; Proliferating Cell Nuclear Antigen; Time Factors; Transforming Growth Factor beta | 1995 |
Regulation of fibronectin mRNA expression in primary hepatocytes in response to EGF and phenobarbital.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Epidermal Growth Factor; Extracellular Matrix; Fibronectins; Gene Expression; In Vitro Techniques; Integrins; Liver; Male; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Collagen; Receptors, Fibronectin; Receptors, Laminin; RNA, Messenger | 1993 |
Responsiveness of hepatocytes from dichloroacetic acid or phenobarbital treated mice to growth factors in primary culture.
Topics: Animals; Cells, Cultured; Dichloroacetic Acid; DNA; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Fibroblast Growth Factor 1; Growth Substances; Hepatocyte Growth Factor; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Phenobarbital; Thymidine; Transforming Growth Factor beta | 1996 |
The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors.
Topics: Animals; Cell Division; Cell Separation; Cells, Cultured; DNA Replication; Drug Synergism; Epidermal Growth Factor; Growth Substances; Hepatocyte Growth Factor; Hyperplasia; Liver; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Time Factors | 1997 |
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.
Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine | 1999 |
EGF-Induced receptor autophosphorylation in primary hepatocytes isolated from phenobarbitone-treated mice.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Liver; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Phosphorylation | 1999 |
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; beta-Naphthoflavone; Blotting, Western; Cell Size; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Isoenzymes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenobarbital; Rifampin; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Vault Ribonucleoprotein Particles | 2000 |
Potentiation of epidermal growth factor-induced DNA synthesis in rat hepatocytes by phenobarbitone: possible involvement of oxidative stress and kinase activation.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Excitatory Amino Acid Antagonists; Hepatocytes; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Oxidative Stress; Phenobarbital; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; S Phase | 2000 |
Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: repression by epidermal growth factor is mediated via a distal enhancer region.
Topics: Animals; Cytochrome P-450 CYP2B1; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Growth Hormone; Hepatocytes; Mice; Permethrin; Phenobarbital; Promoter Regions, Genetic; Protein Binding; Rats; Rats, Wistar; Transcription, Genetic; Transcriptional Activation | 2004 |
Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes.
Topics: Anisomycin; Aryl Hydrocarbon Hydroxylases; Dioxins; Enzyme Activation; Enzyme Activators; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Glucuronosyltransferase; Glutathione Transferase; Hepatocytes; Humans; Phenobarbital; Rifampin; RNA, Messenger; Sorbitol; Sulfotransferases | 2009 |
Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P450 Family 2; Epidermal Growth Factor; ErbB Receptors; GABA Modulators; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Mice; Models, Biological; Phenobarbital; Phosphorylation; Prohibitins; Protein Binding; Protein Phosphatase 2; Rats; Receptors for Activated C Kinase; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Signal Transduction; Steroid Hydroxylases | 2013 |
Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Constitutive Androstane Receptor; Epidermal Growth Factor; ErbB Receptors; GABA Modulators; Hepatocytes; Humans; Male; Mice; Mice, Inbred C3H; Models, Molecular; Phenobarbital; Phosphorylation; Protein Binding; Protein Phosphatase 2; Protein Structure, Tertiary; Receptors for Activated C Kinase; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; RNA Interference; Signal Transduction | 2013 |
Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Cell Proliferation; Cell Survival; Cells, Cultured; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; DNA; Epidermal Growth Factor; Hepatocytes; Humans; Male; Membrane Proteins; Mice; Microscopy, Fluorescence; Oximes; Phenobarbital; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Species Specificity; Steroid Hydroxylases; Thiazoles | 2016 |
Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.
Topics: Adult; Aged; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Hepatocytes; Humans; Male; Middle Aged; Oximes; Peroxisome-Targeting Signal 1 Receptor; Phenobarbital; Recoverin; Signal Transduction; Thiazoles; Transcription, Genetic | 2018 |
Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
Topics: Animals; Cells, Cultured; Constitutive Androstane Receptor; Cytochromes; DNA Replication; Epidermal Growth Factor; Female; Hepatocytes; Humans; Hypnotics and Sedatives; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; Phenobarbital; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid | 2018 |
Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells.
Topics: Active Transport, Cell Nucleus; Cell Nucleus; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytoplasm; Epidermal Growth Factor; Hep G2 Cells; Humans; Okadaic Acid; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription, Genetic; Transcriptional Activation | 2019 |