phenobarbital has been researched along with disulfiram in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (78.57) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 3 (7.14) | 29.6817 |
| 2010's | 5 (11.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Kutt, H | 2 |
| Lang, M; Marselos, M; Törrönen, R | 2 |
| Marselos, M; Törrönen, R | 2 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Hart, FE; Hew, JT; Willson, RA | 1 |
| Campbell, RL; Hettrick, JM; Nigro, ND; Suppnick, JD | 1 |
| Black, HS; Brown, GE; Chan, JT | 1 |
| Autrup, H; Fugaro, S; Harris, CC; Selkirk, JK | 1 |
| Bartosek, I; Colombo, T; Donelli, MG; Guaitani, A; Martini, A; Modica, R; Pacciarini, MA | 1 |
| Chaudhuri, A; Keller, WJ | 1 |
| Masuda, Y; Nakamura, Y | 1 |
| Marselos, M; Vasiliou, V | 1 |
| Igwe, OJ; Que Hee, SS; Wagner, WD | 1 |
| Kim, HL | 1 |
| Kutt, H; Penry, JK | 1 |
| Halsey, MJ | 1 |
| Kashiwagi, M; Norton, TR; Shibata, S; Turlapaty, P | 1 |
| Kutt, H; Verebely, K | 1 |
| Hepner, GW; Vesell, ES | 1 |
| Koe, BK; Weissman, A | 1 |
| Scholler, KL | 2 |
| Müller, E; Scholler, KL; von Plehwe, U | 1 |
| Olesen, OV | 2 |
| Ho, AK; Ho, CC | 1 |
| Laaksonen, M; Törrönen, R | 1 |
| Nousiainen, U | 1 |
| Nousiainen, U; Ryhänen, R | 1 |
| Bertram, B; Frank, N; Frei, E; Schuhmacher, J; Wiessler, M | 1 |
| Andreasen, PB; Milandri, M; Poulsen, HE; Ranek, L | 1 |
| Frosini, M; Fusi, F; Pessina, F; Sgaragli, GP; Tipton, KF; Valoti, M | 1 |
| Kathmann, EC; Lipsky, JJ; Naylor, S | 1 |
3 review(s) available for phenobarbital and disulfiram
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Biochemical and genetic factors regulating dilantin metabolism in man.
Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzyme Induction; Female; Genetics, Medical; Humans; Intestinal Absorption; Isoniazid; Kinetics; Liver Diseases; Male; Metabolism; Microsomes, Liver; Nystagmus, Pathologic; Pedigree; Pharmacogenetics; Phenobarbital; Phenytoin; Rats; Thiazines | 1971 |
Usefulness of blood levels of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, Gas; Dextropropoxyphene; Diazepam; Dicumarol; Disulfiram; Drug Interactions; Epilepsy; Ethosuximide; Humans; Isoniazid; Methylphenidate; Phenethylamines; Phenobarbital; Phenylbutazone; Phenytoin; Primidone; Prochlorperazine; Sulfamethizole; Sulfaphenazole; Thiazines | 1974 |
39 other study(ies) available for phenobarbital and disulfiram
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Interactions of antiepileptic drugs.
Topics: Anti-Infective Agents; Anticonvulsants; Benzodiazepines; Biotransformation; Blood Proteins; Carbamazepine; Dextropropoxyphene; Dicumarol; Disulfiram; Drug Interactions; Ethosuximide; Humans; Intestinal Absorption; Isoniazid; Methylphenidate; Phenethylamines; Phenobarbital; Phenothiazines; Phenytoin; Primidone; Protein Binding; Thiazines | 1975 |
Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. I. Mixed-function oxygenase.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Disulfiram; Ditiocarb; Liver; Male; Membranes; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Phospholipids; Rats; Thiocarbamates | 1976 |
Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. II. D-Glucuronic acid pathway.
Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Dehydrogenases; Disulfiram; Ditiocarb; Female; Glucosephosphate Dehydrogenase; Glucuronates; Glucuronidase; Glucuronosyltransferase; Liver; Phenobarbital; Pyrophosphatases; Rats; Sugar Acids; Thiocarbamates; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid | 1976 |
Comparison of D-glucuronolactone and aldehyde dehydrogenase activities in the rat liver.
Topics: Aldehyde Oxidoreductases; Animals; Cytosol; Disulfiram; Ditiocarb; Glucuronates; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1977 |
Changes in the hepatic copper conent after treatment with foreign compounds.
Topics: Animals; Chelating Agents; Copper; Disulfiram; Liver; Male; Phenobarbital; Pyrazoles; Rats | 1978 |
Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats.
Topics: Animals; Aroclors; Chemical and Drug Induced Liver Injury; Disulfiram; Ethanol; Male; Maleates; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats; Vinyl Chloride; Vinyl Compounds | 1977 |
Breath analysis of 14CO2 production from aminopyrine in the normal rat.
Topics: Aminopyrine; Animals; Breath Tests; Carbon Dioxide; Disulfiram; Fasting; Male; Phenobarbital; Proadifen; Rats; Time Factors; Tissue Distribution | 1979 |
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Benzoflavones; Biotransformation; Chlorides; Cobalt; Diet; Disulfiram; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats | 1978 |
Effects of dietary constituents on ultraviolet light-mediated carcinogenesis.
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Diet; Disulfiram; Female; Glutathione; Keratosis; Mice; Mice, Nude; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Phenobarbital; Radiation Injuries, Experimental; Skin Neoplasms; Ultraviolet Rays | 1978 |
Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon.
Topics: Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Benzopyrenes; Bile Acids and Salts; Colon; Disulfiram; DNA; Flavonoids; Male; Organ Culture Techniques; Phenobarbital; Protein Binding; Rats | 1977 |
Importance of pharmacokinetic studies on cyclophosphamide (NSC-26271) in understanding its cytotoxic effect.
Topics: Animals; Carcinoma 256, Walker; Chloral Hydrate; Cyclophosphamide; Disulfiram; Drug Interactions; Glyceraldehyde; Half-Life; In Vitro Techniques; Liver; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Perfusion; Phenobarbital; Sarcoma, Experimental | 1976 |
New mammalian metabolites of sparteine.
Topics: Alkaloids; Animals; Disulfiram; Feces; Male; Phenobarbital; Rats; Rats, Inbred Strains; Sparteine | 1990 |
Oxidation of diethyldithiocarbamate to disulfiram by liver microsomal cytochrome P-450-containing monooxygenase system.
Topics: Animals; Carbon Tetrachloride Poisoning; Catalase; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Changes in the inducibility of a hepatic aldehyde dehydrogenase by various effectors.
Topics: Aldehyde Dehydrogenase; Animals; Cyanamide; Disulfiram; Enzyme Induction; Isoenzymes; Male; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1989 |
Inhalation pharmacokinetics of 1,2-dichloroethane after different dietary pretreatments of male Sprague-Dawley rats.
Topics: Administration, Inhalation; Animals; Butylated Hydroxyanisole; Disulfiram; Ethylene Dichlorides; Hydrocarbons, Chlorinated; Kinetics; Male; Phenobarbital; Pulmonary Gas Exchange; Rats; Rats, Inbred Strains; Solubility | 1986 |
Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate.
Topics: Animals; Disulfiram; Ethoxyquin; Glutathione; Inactivation, Metabolic; Lethal Dose 50; Lobeline; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Proadifen | 1985 |
The metabolic breakdown of inhalation anaesthetics and their clinical implications.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Disulfiram; Dogs; Ethers; Halothane; Humans; Kidney; Liver; Methoxyflurane; Phenobarbital; Time Factors | 1973 |
A possible mechanism of action of a central stimulant substance isolated from the sea anemone Stoichactis kenti.
Topics: Adrenergic beta-Antagonists; Aggression; Amino Acids; Animals; Behavior, Animal; Chlorpromazine; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Cnidaria; Competitive Behavior; Dihydroxyphenylalanine; Disulfiram; Drug Interactions; Humans; Lethal Dose 50; Male; Methocarbamol; Methyltyrosines; Mice; Molecular Weight; Peptides; Phenobarbital; Reserpine; Sympathetic Nervous System; Tetrabenazine; Time Factors; Tissue Extracts | 1973 |
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.
Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature | 1970 |
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
Topics: Administration, Oral; Adult; Aged; Alcoholism; Aminopyrine; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Disulfiram; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Serum Albumin; Syndrome | 1974 |
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea | 1967 |
Modification of the effects of chloroform on the rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Disulfiram; Enzyme Induction; Microsomes, Liver; Necrosis; Phenobarbital; Preanesthetic Medication; Rats; Thiopental; Transaminases | 1970 |
[Stimulation and depression of toxicity of chloroform for the liver by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chloroform; Depression, Chemical; Disulfiram; Drug Synergism; Female; Liver; Liver Diseases; Necrosis; Phenobarbital; Rats; Stimulation, Chemical | 1970 |
[Potentiation and inhibition of chloroform liver toxicity by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chloroform; Disulfiram; Drug Antagonism; Drug Synergism; Liver; Necrosis; Phenobarbital; Preanesthetic Medication; Rats | 1971 |
Disulfiramum (antabuse) as inhibitor of phenytoin metabolism.
Topics: Adult; Disulfiram; Drug Antagonism; Humans; Male; Phenobarbital; Phenytoin; Primidone; Spectrophotometry | 1966 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatography, Thin Layer; Cyanates; Disulfiram; Drug Synergism; Epilepsy; Humans; Hydroflumethiazide; Imipramine; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone | 1967 |
Ethanol-sedative hypnotic interactions: in vitro studies on Na-K-activated adenosine triphosphatase.
Topics: Animals; Disulfiram; Drug Interactions; Ethanol; Hypnotics and Sedatives; In Vitro Techniques; Kinetics; Male; Methaqualone; Microsomes; Phenobarbital; Pyrazoles; Rats; Sodium-Potassium-Exchanging ATPase | 1980 |
Liver cytosolic aldehyde dehydrogenases in rats with different predisposition to induction by phenobarbital. Partial purification and characterization of the enzymes at basal state.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Cytosol; Disulfiram; Enzyme Induction; Female; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1984 |
The effects of phenobarbital, bis-p-nitrophenyl phosphate and disulfiram on the hydrolysis of propanidid in Wistar rats.
Topics: Animals; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cytosol; Disulfiram; Dogs; Hydrolysis; Liver; Male; Microsomes, Liver; Nitrophenols; Phenobarbital; Propanidid; Rats; Rats, Inbred Strains; Sleep; Time Factors | 1984 |
Serum lipids and hepatic microsomal enzymes with special reference to serum cholinesterase in Wistar rats.
Topics: Animals; Cholinesterases; Disulfiram; Enzyme Induction; Lipids; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Organophosphorus Compounds; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Effects of disulfiram on mixed function oxidase system and trace element concentration in the liver of rats.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Disulfiram; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Trace Elements | 1982 |
Effect of long-term disulfiram administration on rat liver.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Disulfiram; Female; Glutathione; Liver; Microsomes, Liver; Mixed Function Oxygenases; Nitroanisole O-Demethylase; Organ Size; Phenobarbital; Rats | 1980 |
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Ethanol; Fomepizole; In Vitro Techniques; Isoenzymes; Ketoconazole; Mice; Mice, Inbred C57BL; Microsomes, Liver; Monoamine Oxidase Inhibitors; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pyrazoles; Selegiline | 2000 |
Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Amino Acid Sequence; Animals; Cytosol; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Liver; Magnesium Chloride; Mass Spectrometry; Molecular Sequence Data; Phenobarbital; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Retinal Dehydrogenase; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity | 2000 |