phenobarbital has been researched along with dimethylnitrosamine in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (81.82) | 18.7374 |
| 1990's | 9 (13.64) | 18.2507 |
| 2000's | 1 (1.52) | 29.6817 |
| 2010's | 2 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castro, JA; Diaz Gomez, MI; Godoy, HM | 1 |
| Kroeger-Koepke, MB; Michejda, CJ | 1 |
| Hackney, C; Hutton, JJ; Meier, J | 2 |
| Arcos, JC; Argus, MF; Brown, CE; Davies, DL | 1 |
| Chopra, P; Das, PK; Dhar, A; Nayak, NC | 1 |
| Archer, MC; Chau, IY; Dagani, D | 1 |
| Appel, KE; Kunz, HW; Rickart, R; Schwarz, M | 1 |
| Drevon, C; Kuroki, T; Montesano, R | 1 |
| Guengerich, FP | 1 |
| Hirono, I; Uchida, E | 1 |
| Jenssen, D; Ramel, C | 1 |
| Andersen, ME; Jenkins, LJ | 1 |
| Banerjee, S; Conney, AH; Kuntzman, R; Levin, W; Somogyi, A | 1 |
| Frantz, CN; Malling, HV | 1 |
| Czygan, P; Garro, AJ; Greim, H; Hutterer, F; Popper, H; Schaffner, F | 1 |
| Gangolli, SD; Heading, CE; Lake, BG; Lloyd, AG; Phillips, JC | 1 |
| Arcos, JC; Argus, MF; Bryant, GM; Buu-Hoi, NP; Valle, RT | 1 |
| Arcos, JC; Argus, MF; Pastor, KM; Venkatesan, N; Wu, BC | 1 |
| Armato, U; Carcereri dePrati, A; Menapace, L; Menegazzi, M; Miwa, M; Ribecco, M; Suzuki, H; Testolin, L | 1 |
| Appel, KE; Hildebrandt, AG; Scheper, T; Schunack, W; Somogyi, A | 1 |
| Furuya, K; Mori, H; Stenbäck, F; Williams, GM | 1 |
| Enomoto, T; Perantoni, AO; Reed, CD; Rice, JM; Watatani, M; Wenk, ML | 1 |
| Klaunig, JE; Pereira, MA; Weghorst, CM | 1 |
| Cater, KC; Gandolfi, AJ; Sipes, IG | 1 |
| Diwan, BA; Ohshima, M; Rice, JM | 1 |
| Kärki, NT; Keinänen, K; Saarni, HU; Sotaniemi, EA; Stenbäck, F; Stengård, JH | 1 |
| Kaufman, DG; Kaufmann, WK; MacKenzie, SA; Rahija, RJ | 1 |
| Kaufman, DG; Kaufmann, WK; Ririe, DG | 1 |
| Mori, H; Tanaka, T; Williams, GM | 1 |
| Bartsch, H; Brun, G; Gelboin, HV; Malaveille, C; Park, SS | 1 |
| Holsapple, MP; Johnson, KW; Kim, DH; Munson, AE | 1 |
| Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A | 1 |
| Kaufmann, WK; Novicki, DL; Tsao, MS | 1 |
| Archer, MC; Silinskas, KC; Zucker, PF | 1 |
| Driver, HE; McLean, AE | 1 |
| Buchmann, A; Klormann, H; Kunz, W; Schrenk, D; Schwarz, M | 1 |
| Kaufman, DG; Kaufmann, WK; MacKenzie, SA | 1 |
| Osin'kovskaia, ND; Rubenchik, BL | 1 |
| Abraham, R; Charles, AK; Timchalk, C | 1 |
| Anders, MW; Aniya, Y | 1 |
| Dietz, D; Kornbrust, D | 1 |
| Bosmann, HB; Chin, AE | 1 |
| Stengård, JH | 1 |
| Shertzer, HG | 1 |
| Gibson, GG; Ioannides, C; Masson, HA | 1 |
| Arai, M; Hibino, T; Hirasawa, Y; Ouchi, N; Takino, H | 1 |
| Baker, MT; Evans, JS; Holmes, D; Wade, AE | 1 |
| Boĭm, TM; Rubenchik, BL; Tsapenko, VF | 1 |
| Kasuya, Y; Kawanishi, T; Nakadate, M; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A | 1 |
| López-Revilla, R; Mendoza-Figueroa, T; Villa-Treviño, S | 1 |
| Bunce, OR; Harley, W; Wade, AE | 1 |
| Mitchell, VD; Prival, MJ | 1 |
| Driver, HE; McLean, AE; Smith, M | 1 |
| Hajek, KK; Novak, RF | 1 |
| Arcos, JC; Argus, MF; Lai, DY | 1 |
| Cantelli-Forti, G; Mesirca, R; Paolini, M; Pozzetti, L; Sapone, A | 1 |
| Armato, U; Carcereri De Prati, A; Menapace, L; Menegazzi, M; Ribecco, M; Suzuki, H; Testolin, L; Wu, J | 1 |
| Callander, RD; Clay, P; Elcombe, CR; Elliott, BM; Mackay, JM | 1 |
| Hollenberg, PF; Shu, L | 1 |
| Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
| Frei, E; Hansíková, H; Stiborová, M | 1 |
| Fujiwara, K; Ogata, I; Tomiya, T | 1 |
| Hodek, P; Kubícková, B; Máslová, V; Sulc, M | 1 |
| Castañeda-Partida, L; Delfín-Alcalá, I; Dueñas-García, IE; Durán-Díaz, A; Guzmán-Rincón, J; Heres-Pulido, ME; Hernández-Portilla, LB | 1 |
| Becker, K; Boger, RJ; Ehrenberg, KR; Hahn, M; Hövelmeyer, N; Jäger, D; Longerich, T; Schuchmann, M; Schulze-Bergkamen, H; Urbanik, T; Waisman, A; Wörns, MA | 1 |
66 other study(ies) available for phenobarbital and dimethylnitrosamine
| Article | Year |
|---|---|
Mechanism of dimethylnitrosamine metabolism and activation in rats.
Topics: Animals; Biotransformation; Carbon Dioxide; Cobalt; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrosamines; Nucleic Acids; Phenobarbital; Proadifen; Protein Binding; Rats; Subcellular Fractions | 1978 |
Evidence for several demethylase enzymes in the oxidation of dimethylnitrosamine and phenylmethylnitrosamine by rat liver fractions.
Topics: Animals; Deuterium; Dimethylnitrosamine; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Subcellular Fractions | 1979 |
Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.
Topics: Animals; Benzopyrenes; Biotransformation; Dimethylnitrosamine; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Mutagens; Nitrosamines; Phenobarbital; Polychlorinated Biphenyls; Tissue Distribution | 1979 |
Mutagenicity and metabolism of dimethylnitrosamine and benzo[alpha]pyrene in tissue homogenates from inbred Syrian hamsters treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.
Topics: Animals; Benzopyrenes; Biotransformation; Cricetinae; Dimethylnitrosamine; Female; Genetic Techniques; Inbreeding; Intestinal Mucosa; Liver; Lung; Mesocricetus; Methylcholanthrene; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonella typhimurium | 1979 |
Repressible and inducible enzymic forms of dimethylnitrosamine-demethylase.
Topics: Animals; Dimethylnitrosamine; Enzyme Induction; Enzyme Repression; Humans; Liver; Methylcholanthrene; Mice; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Structure-Activity Relationship | 1977 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Fetus; Glucose-6-Phosphatase; Hepatectomy; Liver; Liver Diseases; Necrosis; Nitrosamines; Phenobarbital; Rats; Triglycerides | 1975 |
Kinetic studies on the hepatic microsomal metabolism of dimethylnitrosamine, diethylnitrosamine, and methylethylnitrosamine in the rat.
Topics: Animals; Binding Sites; Binding, Competitive; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nitrosamines; Phenobarbital; Rats | 1978 |
Effect of DMN, phenobarbital and halothane on the sedimentation characteristics of rat liver DNA.
Topics: Animals; Centrifugation, Density Gradient; Dimethylnitrosamine; DNA; Halothane; Hepatectomy; Liver; Male; Nitrosamines; Phenobarbital; Rats | 1979 |
Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines.
Topics: Acetonitriles; Animals; Azaguanine; Cell Line; Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Drug Resistance; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Rats; Salmonella typhimurium | 1977 |
Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.
Topics: Aflatoxins; Animals; Benzopyrenes; Benzphetamine; Carbamates; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Furans; Lung; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; p-Aminoazobenzene; p-Dimethylaminoazobenzene; Parathion; Phenobarbital; Pyrrolizidine Alkaloids; Rabbits; Rats; Terpenes; Toxins, Biological | 1977 |
Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.
Topics: Adenoma; Animals; Animals, Newborn; Dimethylnitrosamine; Drug Synergism; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms, Experimental; Phenobarbital | 1979 |
Factors affecting the induction of micronuclei at low doses of X-rays, MMS and dimethylnitrosamine in mouse erythroblasts.
Topics: Animals; Caffeine; Cell Cycle; Cell Nucleus; Chromosome Aberrations; Dimethylnitrosamine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Erythroblasts; Erythrocytes; Male; Methyl Methanesulfonate; Mice; Mice, Inbred CBA; Mutagens; Phenobarbital; X-Rays | 1978 |
The toxicity of single doses of N-nitrodimethylamine in rodents.
Topics: Animals; Biotransformation; Dimethylamines; Dimethylnitrosamine; Female; Male; Mice; Microsomes, Liver; Nitro Compounds; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors | 1978 |
Inhibition of the acute toxicity and adrenocorticolytic effect of 7,12-dimethylbenz(a)anthracene by isopropylvaleramide and allylisopropylacetamide in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetamides; Adrenal Cortex; Adrenal Glands; Allylisopropylacetamide; Amides; Animals; Barbiturates; Benz(a)Anthracenes; Benzopyrenes; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Methylcholanthrene; Pentobarbital; Phenobarbital; Proadifen; Rats; Secobarbital; Time Factors; Valerates | 1975 |
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Histidine; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Proadifen; Salmonella typhimurium; Time Factors; Valerates | 1975 |
Cytochrome P-450 in the activation and inactivation of carcinogens.
Topics: Animals; Aroclors; Biotransformation; Carcinogens; Choline Deficiency; Cytochrome P-450 Enzyme System; Deficiency Diseases; Dimethylnitrosamine; Humans; In Vitro Techniques; Inactivation, Metabolic; Kinetics; Liver; Male; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Photochemistry | 1975 |
Studies on the metabolism of dimethylnitrosamine in the rat. II. The effects of phenobarbitone and 20-methylcholanthrene on the in vitro and in vivo metabolism and acute toxicity of dimethylnitrosamine in young and mature rats.
Topics: Age Factors; Aminopyrine; Aniline Hydroxylase; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sex Factors | 1975 |
Dimethylnitrosamine-demethylase: molecular size-dependence of repression by polynuclear hydrocarbons. Nonhydrocarbon repressors.
Topics: Animals; Dimethylnitrosamine; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Oxidoreductases, N-Demethylating; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Rats | 1976 |
Dimethylnitrosamine-demethylase: absence of increased enzyme catabolism and multiplicity of effector sites in repression. Hemoprotein involvement.
Topics: Animals; Carbon Monoxide; Caseins; Cytochrome P-450 Enzyme System; Dietary Proteins; Dimethylnitrosamine; Enzyme Repression; Hemeproteins; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1976 |
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethylnitrosamine; DNA Replication; Epidermal Growth Factor; Female; Kinetics; Liver; Liver Neoplasms; Maternal-Fetal Exchange; Mutagenesis; Phenobarbital; Poly(ADP-ribose) Polymerases; Precancerous Conditions; Pregnancy; Rats; Rats, Inbred Strains; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic | 1992 |
Metabolic denitrosation of N-nitroso-N-methylaniline: detection of amine-metabolites.
Topics: Aniline Compounds; Animals; Dimethylnitrosamine; Female; In Vitro Techniques; Kinetics; Mice; Microsomes, Liver; Nitrosamines; Phenobarbital | 1991 |
Pathogenesis of dimethylnitrosamine-induced hepatocellular cancer in hamster liver and lack of enhancement by phenobarbital.
Topics: Animals; Bile Ducts; Cricetinae; Dimethylnitrosamine; gamma-Glutamyltransferase; Histocytochemistry; Iron; Liver; Liver Neoplasms, Experimental; Mesocricetus; Phenobarbital; Staining and Labeling; Time Factors | 1986 |
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Female; Genes, ras; Liver Neoplasms, Experimental; Male; Nucleic Acid Hybridization; Phenobarbital; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Transfection | 1989 |
Strain differences in hepatic tumor promotion by phenobarbital in diethylnitrosamine- and dimethylnitrosamine-initiated infant male mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital; Reference Values; Species Specificity | 1989 |
Characterization of dimethylnitrosamine-induced focal and nodular lesions in the livers of newborn mice.
Topics: Animals; Animals, Newborn; Body Weight; Dimethylnitrosamine; Female; gamma-Glutamyltransferase; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; Sex Factors | 1985 |
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cocarcinogenesis; Dimethylnitrosamine; Intestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms | 1989 |
Medroxyprogesterone acetate and phenobarbital induce NADPH producing enzyme activities in rats with a chemical liver injury.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Induction; Glucose-6-Phosphatase; Isocitrate Dehydrogenase; Malate Dehydrogenase; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; NADP; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Rats, Inbred Strains | 1985 |
Quantitative relationship between initiation of hepatocarcinogenesis and induction of altered cell islands.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Dimethylnitrosamine; DNA; Gamma Rays; Hepatectomy; Kinetics; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Neoplasms, Radiation-Induced; Phenobarbital; Rats; Rats, Inbred F344 | 1986 |
Phenobarbital-dependent proliferation of putative initiated rat hepatocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Division; Cells, Cultured; Dimethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1988 |
Enhancement of dimethylnitrosamine-initiated hepatocarcinogenesis in hamsters by subsequent administration of carbon tetrachloride but not phenobarbital or p,p'-dichlorodiphenyltrichloroethane.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Cricetinae; DDT; Dimethylnitrosamine; Liver Neoplasms, Experimental; Male; Mesocricetus; Phenobarbital; Species Specificity | 1987 |
A monoclonal antibody against cytochrome P-450 enhances mutagen activation of N-nitrosodimethylamine by mouse liver S9: studies on the mode of action.
Topics: Animals; Antibodies, Monoclonal; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Dimethylnitrosamine; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutagenicity Tests; Phenobarbital; Salmonella typhimurium | 1987 |
Dependence on intact cells for the in vitro activation of dimethylnitrosamine to an immunosuppressive form.
Topics: 1-Propanol; Animals; Antibody Formation; Biotransformation; Cell-Free System; Dimethylnitrosamine; Immunosuppressive Agents; Liver; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagenicity Tests; Oxidoreductases, N-Demethylating; Phenobarbital; Spleen | 1987 |
Different effects of chemicals on metabolism of N-nitrosamines in rat liver.
Topics: Animals; Dimethylnitrosamine; Ethanol; Liver; Methylcholanthrene; Nitrosamines; Phenobarbital; Pyrazoles; Rats | 1987 |
In vitro colonization ability appears soon after initiation of hepatocarcinogenesis in the rat.
Topics: Animals; Dimethylnitrosamine; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1986 |
Mechanism of organ specificity in nitrosamine carcinogenesis.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Esophageal Neoplasms; Liver; Liver Neoplasms, Experimental; Neoplasms, Experimental; Phenobarbital; Rats | 1986 |
Dose-response relationship for phenobarbitone promotion of liver tumours initiated by single dose dimethylnitrosamine.
Topics: Animals; Cytochrome P-450 Enzyme System; Diet; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Oxazines; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Effect of phenobarbital and other liver monooxygenase modifiers on dimethylnitrosamine-induced alkylation of rat liver macromolecules.
Topics: Alkylation; Animals; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Ethanol; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1985 |
Quantitative relationship between hepatocytic neoplasms and islands of cellular alteration during hepatocarcinogenesis in the male F344 rat.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors | 1985 |
[Transplacental effect of sodium nitrite on rat lung cells with their subsequent culture in the medium with precursors of N-nitrosodimethylamine].
Topics: Aminopyrine; Animals; Ascorbic Acid; Cell Survival; Culture Media; Dimethylnitrosamine; Drug Synergism; Female; Fetus; In Vitro Techniques; Lung; Maternal-Fetal Exchange; Mitosis; Nitrites; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sodium Nitrite; Vitamin E | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; Insecticides; Liver; Liver Neoplasms; Male; Mirex; Neoplasm Proteins; Phenobarbital; Precancerous Conditions; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
Alteration of hepatic glutathione S-transferases and release into serum after treatment with bromobenzene, carbon tetrachloride, or N-nitrosodimethylamine.
Topics: Animals; Bromobenzenes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytosol; Dimethylnitrosamine; Ethanol; Glutathione Transferase; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; DDT; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Liver; Male; Methyl Methanesulfonate; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Hepatic microsomal metabolism of N-nitrosodimethylamine to its methylating agent.
Topics: Alkylating Agents; Animals; Dimethylnitrosamine; DNA; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Proteins; Rats; RNA | 1980 |
A comparison of the effects of phenobarbital and medroxyprogesterone acetate on drug and glucose metabolism in rats with chemical liver injury.
Topics: Animals; Dimethylnitrosamine; Glucose; Liver; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse liver macromolecules.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Dimethylnitrosamine; DNA; Indoles; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Rats | 1984 |
The role of highly purified forms of rat liver cytochrome P-450 in the dimethylation of dimethylnitrosamine and its activation to mutagens.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Isoenzymes; Male; Microsomes, Liver; Mutagens; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Comparative enhancing effects of polychlorinated biphenyls and phenobarbital on dimethylnitrosamine-induced hepatic and renal tumorigenesis in rats.
Topics: Animals; Dimethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Male; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred F344 | 1983 |
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.
Topics: Aniline Compounds; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Dimethylnitrosamine; Ethylmorphine; Female; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organ Size; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Thiamine; Thiamine Deficiency | 1983 |
[Possibility of N-dimethylnitrosamine formation after parenteral administration of amidopyrine and nitrite to rats].
Topics: Aminopyrine; Animals; Ascorbic Acid; Dimethylnitrosamine; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Necrosis; Nitrites; Phenobarbital; Rats | 1984 |
Effect of phenobarbital and 3-methylcholanthrene on the hepatic microsomal metabolism of N-nitrosodimethylamine, N-nitrosomethylbutylamine and N-nitrosomethylbenzylamine.
Topics: Animals; Chromatography, Gas; Dimethylnitrosamine; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
DNA breaks induced by micromolar concentrations of dimethylnitrosamine in liver primary cell cultures from untreated and phenobarbital treated rats.
Topics: Animals; Cell Survival; Cells, Cultured; Centrifugation, Density Gradient; Dimethylnitrosamine; DNA; Drug Interactions; Liver; Male; Methylnitronitrosoguanidine; Molecular Weight; Mutagenicity Tests; Phenobarbital; Rats; Rats, Inbred Strains; Thymidine; Time Factors | 1983 |
The effects of dietary corn oil on the metabolism and mutagenic activation on N-nitrosodimethylamine (DMN) by hepatic microsomes from male and female rats.
Topics: Animals; Biotransformation; Corn Oil; Dimethylnitrosamine; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oils; Phenobarbital; Rats; Salmonella typhimurium; Sex Factors; Stimulation, Chemical | 1982 |
Influence of microsomal and cytosolic fractions from rat, mouse, and hamster liver on the mutagenicity of dimethylnitrosamine in the Salmonella plate incorporation assay.
Topics: Animals; Aroclors; Biotransformation; Cell Fractionation; Cricetinae; Cytosol; Dimethylnitrosamine; Methods; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats; Salmonella typhimurium | 1981 |
Liver tumours after single dose dimethylnitrosamine, low and high protein diet, and phenobarbitone.
Topics: Animals; Dietary Proteins; Dimethylnitrosamine; Liver Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Spectral and metabolic properties of liver microsomes from imidazole-pretreated rabbits.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rabbits; Spectrophotometry | 1982 |
Interaction of the tobacco-specific nitrosamines, methylethylnitrosamine and N-nitrosonornicotine, with DNA and guanosine.
Topics: Animals; Benzylamines; Dimethylnitrosamine; DNA; Guanosine; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Nicotiana; Nicotine; Nitrosamines; Phenobarbital; Plants, Toxic; Rats | 1980 |
Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Barbital; Carcinogens; Cricetinae; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Dimethylnitrosamine; Enzyme Induction; Female; Ketones; Kidney; Liver; Lung; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred Strains; Phenobarbital; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity; Steroid Hydroxylases; Substrate Specificity | 1995 |
The in utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression of c-jun and c-myc oncogenes in primary neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Biotechnology; Cells, Cultured; Dimethylnitrosamine; Female; Genes, jun; Genes, myc; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Maternal-Fetal Exchange; Phenobarbital; Pregnancy; Rats | 1993 |
Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays.
Topics: Administration, Oral; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcinogens; Chlorodiphenyl (54% Chlorine); Chromosome Aberrations; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Female; Humans; Liver Extracts; Lymphocytes; Male; Mutagenicity Tests; Phenobarbital; Rats; Salmonella typhimurium | 1995 |
Role of cytochrome P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cells, Cultured; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; DNA Damage; DNA Repair; Enzyme Induction; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Inbred F344; Steroid Hydroxylases | 1996 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
Cytochromes P450 2B1 and P450 2B2 demethylate N-nitrosodimethylamine and N-nitrosomethylaniline in vitro.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Kinetics; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrosamines; Phenobarbital; Phosphatidylcholines; Rats; Spectrophotometry; Steroid Hydroxylases; Substrate Specificity | 1996 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal; Hepatocyte Growth Factor; Liver; Liver Regeneration; Male; Mitotic Index; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha | 1998 |
Rabbit liver microsomal system: study of interaction with two model N-nitrosamines and their metabolism.
Topics: Animals; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ethanol; Liver; Male; Microsomes, Liver; Nitrosamines; Phenobarbital; Rabbits | 2004 |
Lead acetate does not inhibit dimethylnitrosamine activation and interacts with phenobarbital which is genotoxic in the ST cross of the Drosophila wing spot test.
Topics: Animals; Dimethylnitrosamine; Drosophila; Mutagens; Organometallic Compounds; Phenobarbital; Wings, Animal | 2011 |
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.
Topics: Animals; Biliary Tract Diseases; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Dimethylnitrosamine; Disease Models, Animal; Exons; Fibrosis; Gene Deletion; Genetic Predisposition to Disease; Homeostasis; In Vitro Techniques; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenobarbital; Phenotype; Risk Factors | 2012 |