phenobarbital has been researched along with dimethyl sulfoxide in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (58.54) | 18.7374 |
| 1990's | 9 (21.95) | 18.2507 |
| 2000's | 4 (9.76) | 29.6817 |
| 2010's | 4 (9.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Matsushima, T; Nagao, M; Seino, Y; Sugimura, T; Yahagi, T | 1 |
| Crawford, RD; Davis, HL; Johnson, DD | 1 |
| Hart, FE; Willson, RA | 2 |
| Godoy, HM; Neal, GE | 1 |
| Hamada, K; Teranishi, K; Watanabe, H | 1 |
| Bresnick, E; Procaccini, RL | 1 |
| Briand, J; Julistiono, H | 1 |
| Koole-Lesuis, H; van den Berg, JW; Visser, O; Voortman, G; Wilson, JH | 1 |
| Decloitre, F; Frayssinet, C; Lafarge-Frayssinet, C; Martin, M | 1 |
| Klaunig, JE; Pereira, MA; Ruch, RJ | 1 |
| Guzelian, PS; Li, D; Schuetz, EG | 1 |
| Handa, Y; Miyazaki, M; Sato, J | 1 |
| Cronholm, T; Ekström, G; Ingelman-Sundberg, M | 1 |
| Maier, P | 1 |
| Bartsch, H; Brun, G; Gelboin, HV; Malaveille, C; Park, SS | 1 |
| Bentley, P; Bieri, F; Muakkassah-Kelly, SF; Stäubli, W; Waechter, F | 1 |
| Kyogoku, Y; Yu, BS | 1 |
| Carter, EA; Isselbacher, KJ | 1 |
| Bösenberg, H; Grass, S; Kruse, P; Norpoth, K; Witting, U | 1 |
| Bresnick, E; Cutroneo, KR | 1 |
| Diamond, L; Gelboin, HV; Leutz, JC; Wiebel, FJ | 1 |
| Fouts, JR; Stock, BH | 1 |
| Siegers, CP; Younes, M | 1 |
| Coon, MJ; Koop, DR; Morgan, ET | 1 |
| Mackenroth, T; Siegers, CP; Younes, M | 1 |
| Asano, T; Nakajima, A; Shimada, O; Yasuda, H | 1 |
| Martini, R; Murray, M | 1 |
| Maier, P; Schawalder, H | 1 |
| Guigoz, Y; Honegger, P; Juillerat, M; Schilter, B; Turesky, RJ | 1 |
| Kubova, H; Lanstiakova, M; Mares, P; Mockova, M; Vorlicek, J | 1 |
| Novak, RF; Zangar, RC | 1 |
| Demiryürek, AT; Yildiz, G | 1 |
| Kamiya, A; Kinoshita, T; Kojima, N; Miyaijma, A; Sakai, Y | 1 |
| Fiala-Beer, E; Murray, M; Sutton, D | 1 |
| Anzenbacherová, E; Dvorák, Z; Simánek, V; Sperlíková, L; Ulrichová, J; Zdarilová, A | 1 |
| Etzrodt, J; Glöckner, R; Lupp, A; Müller, D | 1 |
| Cai, H; Chen, S; Hotz, K; La Placa, DB; Nguyen, N; Peterkin, V; Stevens, JC; Tukey, RH; Yang, YS | 1 |
| Savani, M; Skubitz, KM | 1 |
| Forcelli, PA; Huizenga, MN | 1 |
41 other study(ies) available for phenobarbital and dimethyl sulfoxide
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mutagenicities of N-nitrosamines on Salmonella.
Topics: Animals; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Activation; Male; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Polychlorinated Biphenyls; Rats; Salmonella typhimurium; Structure-Activity Relationship | 1977 |
Epileptiform seizures in domestic fowl. VIII. Anticonvulsant activity of primidone and its metabolites, phenobarbital and phenylethylmalonamide.
Topics: Animals; Anticonvulsants; Chickens; Dimethyl Sulfoxide; Female; Male; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone; Proadifen; Time Factors | 1978 |
Effect of parenteral dimethyl sulfoxide (DMSO) on drug metabolizing enzyme activities in the phenobarbital pretreated rat.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Bilirubin; Cytochrome P-450 Enzyme System; Depression, Chemical; Dimethyl Sulfoxide; Drug Interactions; Glucuronates; Hexosyltransferases; Injections, Intraperitoneal; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Time Factors | 1977 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Glutathione; In Vitro Techniques; Liver Diseases; Male; Methionine; Microsomes, Liver; Phenobarbital; Rats; Solvents | 1977 |
The effect of pre-treatment with phenobarbitone on the activation of aflatoxin B1 by rat liver.
Topics: Aflatoxins; Animals; Dimethyl Sulfoxide; DNA-Directed RNA Polymerases; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; RNA; Subcellular Fractions; Time Factors; Transcription, Genetic | 1976 |
Quantitative relationship between carcinogenicity and mutagenicity of polyaromatic hydrocarbons in Salmonella typhimurium mutants.
Topics: Air Pollutants; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Survival; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Code; Hydrocarbons; Liver; Liver Extracts; Male; Methylcholanthrene; Mutagens; Mutation; Phenobarbital; Rats; Salmonella typhimurium; Transcription, Genetic | 1975 |
Histone modification in liver after administration of inducers of mixed function oxidase activity.
Topics: Acetates; Animals; Cell Nucleus; Dimethyl Sulfoxide; Histones; Liver; Male; Methylcholanthrene; Phenobarbital; Phosphoproteins; Rats | 1975 |
Microsomal ethanol-oxidizing system in Euglena gracilis. Similarities between Euglena and mammalian cell systems.
Topics: Alcohol Dehydrogenase; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochromes b5; Dimethyl Sulfoxide; Enzyme Induction; Ethanol; Euglena gracilis; Mammals; Microsomes; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxygen Consumption; Phenobarbital | 1992 |
Porphyrin synthesis by human hepatocytes and HepG2 cells--effects of enzyme inducers and delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Hexachlorobenzene; Humans; Hydroxymethylbilane Synthase; Liver; Liver Neoplasms; Methylcholanthrene; Phenobarbital; Porphyrins; Tumor Cells, Cultured; Uroporphyrinogen Decarboxylase | 1991 |
Modifications of microfilaments and microtubules induced by two hepatic tumor promoters, phenobarbital and biliverdin in non-transformed and transformed hepatic cell lines.
Topics: Actin Cytoskeleton; Actins; Animals; Bilirubin; Biliverdine; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoskeleton; Dimethyl Sulfoxide; Fluorescent Antibody Technique; gamma-Glutamyltransferase; Liver; Microtubules; Phenobarbital; Phenotype; Rats; Rhodamines; Tubulin | 1990 |
Inhibition of intercellular communication between mouse hepatocytes by tumor promoters.
Topics: Animals; Aroclors; Carcinogens; Cell Communication; Cells, Cultured; Chlorodiphenyl (54% Chlorine); DDT; Dimethyl Sulfoxide; Hexachlorocyclohexane; Liver; Male; Mice; Phenobarbital; RNA; Tetradecanoylphorbol Acetate; Uridine | 1987 |
Induction of cytochromes P-450b/e by phenobarbital in primary culture of adult rat hepatocytes: test of differentiated liver gene expression.
Topics: Animals; Blotting, Northern; Cells, Cultured; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Gene Expression; Isoenzymes; Liver; Microsomes, Liver; Phenobarbital; Rats | 1989 |
Effect of phenobarbital on adult rat liver cells treated with 3'-methyl-4-dimethylaminoazobenzene in primary culture.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Synergism; gamma-Glutamyltransferase; Liver; Male; Methyldimethylaminoazobenzene; Microscopy, Phase-Contrast; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Hydroxyl-radical production and ethanol oxidation by liver microsomes isolated from ethanol-treated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Ethanol; Free Radicals; Hydroxides; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Development of in vitro toxicity tests with cultures of freshly isolated rat hepatocytes.
Topics: Animals; Cells, Cultured; Dimethyl Sulfoxide; DNA; Drug-Related Side Effects and Adverse Reactions; Fetal Blood; Flow Cytometry; Liver; Oxygen; Phenobarbital; Ploidies; Proteins; Rats; Rats, Inbred Strains | 1988 |
A monoclonal antibody against cytochrome P-450 enhances mutagen activation of N-nitrosodimethylamine by mouse liver S9: studies on the mode of action.
Topics: Animals; Antibodies, Monoclonal; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Dimethylnitrosamine; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutagenicity Tests; Phenobarbital; Salmonella typhimurium | 1987 |
Long-term maintenance of hepatocytes in primary culture in the presence of DMSO: further characterization and effect of nafenopin, a peroxisome proliferator.
Topics: Animals; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; DNA; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Methylcholanthrene; Microbodies; Microscopy, Electron; Nafenopin; Oxidoreductases; Palmitoyl Coenzyme A; Phenobarbital; Propionates; Rats; Rats, Inbred Strains | 1987 |
Selective binding of barbital to the adenine moieties of FAD and NAD.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Barbiturates; Chemical Phenomena; Chemistry; Deuterium; Dimethyl Sulfoxide; Flavin-Adenine Dinucleotide; Fluorometry; Infrared Rays; Magnetic Resonance Spectroscopy; Methylation; Models, Chemical; NAD; Optical Rotatory Dispersion; Phenobarbital; Spectrophotometry; Ultraviolet Rays | 1970 |
The role of microsomes in the hepatic metabolism of ethanol.
Topics: Acetates; Adenine Nucleotides; Aerobiosis; Amino Alcohols; Anaerobiosis; Animals; Azides; Bile Acids and Salts; Carbon Monoxide; Catalase; Cell Fractionation; Chlorides; Chloromercuribenzoates; Copper; Cyanides; Diet; Dimethyl Sulfoxide; Edetic Acid; Ethanol; Female; Hot Temperature; Hydrogen Peroxide; Iron; Liver; Mercury; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Pyrazoles; Rats; Sulfides; Triazoles | 1971 |
[Spectrophotometric investigations of aflatoxin B1 binding to rat liver microsomes (author's transl)].
Topics: Aflatoxins; Animals; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Female; Germ-Free Life; Male; Microsomes, Liver; Phenobarbital; Proteins; Rats; Spectrophotometry, Ultraviolet | 1974 |
Induction of benzpyrene hydroxylase in fetal liver explants by flavones and phenobarbital.
Topics: Animals; Benzopyrenes; Carbon Isotopes; Dimethyl Sulfoxide; DNA; Enzyme Induction; Female; Fetus; Flavonoids; Leucine; Liver; Mixed Function Oxygenases; Organ Culture Techniques; Orotic Acid; Phenobarbital; Pregnancy; Protein Biosynthesis; Rats; RNA; Thymidine | 1973 |
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat tissues: differential inhibition and stimulation by benzoflavones and organic solvents.
Topics: 1-Propanol; Acetone; Alcohols; Animals; Benz(a)Anthracenes; Benzopyrenes; Cells, Cultured; Cricetinae; Dimethyl Sulfoxide; Embryo, Mammalian; Enzyme Induction; Ethanol; Flavonoids; In Vitro Techniques; Kidney; Lung; Male; Methanol; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Phenobarbital; Rats; Skin | 1971 |
The influence of in vivo administration of dimethyl sulfoxide on the in vitro metabolism of some monocyclic aromatic chemicals by hepatic microsomal preparations.
Topics: Acetanilides; Aniline Compounds; Animals; Anisoles; Biotransformation; Cycloheximide; Cytochromes; Dactinomycin; Dimethyl Sulfoxide; Female; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Phenobarbital; Rabbits; Rats; Stimulation, Chemical | 1971 |
Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein.
Topics: Acetaminophen; Animals; Catechin; Chemical and Drug Induced Liver Injury; Deanol; Dimethyl Sulfoxide; Ditiocarb; In Vitro Techniques; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Time Factors | 1980 |
Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.
Topics: Animals; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Ethanol; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rabbits; Substrate Specificity; Superoxide Dismutase | 1982 |
[Inhibition and acceleration of the metabolism of enflurane and methoxyflurane in rats (author's transl)].
Topics: Animals; DDT; Dimethyl Sulfoxide; Drug Interactions; Enflurane; Ethanol; Half-Life; Male; Maleates; Methoxyflurane; Phenobarbital; Rats; Rifampin | 1981 |
Cerebral protective effect and radical scavenging action.
Topics: Animals; Ascorbic Acid; Biphenyl Compounds; Brain; Dimethyl Sulfoxide; Hydrazines; Imidazoles; Indicators and Reagents; Lipid Peroxides; Male; Mitochondria; Mitochondria, Liver; Pentobarbital; Phenobarbital; Picrates; Rats; Rats, Inbred Strains | 1981 |
Retinal dehydrogenation and retinoic acid 4-hydroxylation in rat hepatic microsomes: developmental studies and effect of foreign compounds on the activities.
Topics: Aging; Aldehyde Oxidoreductases; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Female; Hydrogenation; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Retinal Dehydrogenase; Retinaldehyde; Tretinoin | 1994 |
Physiological oxygen tension modulates the chemically induced mitogenic response of cultured rat hepatocytes.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cyproterone Acetate; Dimethyl Sulfoxide; DNA; Flow Cytometry; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Mitosis; Oxygen; Phenobarbital; Ploidies; Proteins; Rats; Rats, Sprague-Dawley; S Phase | 1993 |
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Cells, Cultured; Dimethyl Sulfoxide; Drug Synergism; Enzyme Induction; Glutathione Transferase; Liver; Methylcholanthrene; Phenobarbital; Quinoxalines; Rats; Xenobiotics | 1993 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Male; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Severity of Illness Index; Valproic Acid | 1996 |
Posttranslational elevation of cytochrome P450 3A levels and activity by dimethyl sulfoxide.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Kinetics; Liver; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Polyribosomes; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid Hydroxylases; Substrate Specificity; Testosterone; Time Factors; Transcription, Genetic | 1998 |
Ferrous iron-induced luminol chemiluminescence: a method for hydroxyl radical study.
Topics: Catalase; Dimethyl Sulfoxide; Ferrous Compounds; Hydroxyl Radical; Luminescent Measurements; Phenobarbital; Superoxide Dismutase | 1998 |
Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase.
Topics: Animals; Antibodies; Cell Differentiation; Cells, Cultured; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Activation; Excitatory Amino Acid Antagonists; Extracellular Matrix; Fetus; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Growth Inhibitors; Hepatocytes; In Vitro Techniques; Integrin beta1; Mice; Mice, Inbred C57BL; Oncostatin M; Peptides; Phenobarbital; Sarcoma, Experimental; Signal Transduction; Tryptophan Oxygenase | 2002 |
Upregulation of cytochromes P450 2B in rat liver by orphenadrine.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Gene Expression Regulation; Injections, Intraperitoneal; Male; Microsomes, Liver; Orphenadrine; Phenobarbital; Protein Biosynthesis; Rats; Rats, Wistar; Up-Regulation | 2003 |
Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital.
Topics: Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hepatocytes; Isoquinolines; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Time Factors | 2006 |
Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.
Topics: Aging; Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Enzyme Inhibitors; Hydroxylation; Liver; Male; Mixed Function Oxygenases; Organ Culture Techniques; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Testosterone; Time Factors | 2008 |
A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.
Topics: Alleles; Animals; Anticholesteremic Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Azetidines; Biocatalysis; Camptothecin; Dimethyl Sulfoxide; Enzyme Induction; Ezetimibe; Gene Expression; Glucuronic Acid; Glucuronosyltransferase; Humans; Irinotecan; Kinetics; Liver; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microsomes, Liver; Models, Animal; Naloxone; Pharmaceutical Preparations; Phenobarbital; UDP-Glucuronosyltransferase 1A9 | 2010 |
Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cardiotoxicity; Dimethyl Sulfoxide; Doxorubicin; Female; Humans; Ifosfamide; Osteosarcoma; Phenobarbital; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2019 |
Neuroprotective Action of the CB1/2 Receptor Agonist, WIN 55,212-2, against DMSO but Not Phenobarbital-Induced Neurotoxicity in Immature Rats.
Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cell Death; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Male; Morpholines; Naphthalenes; Neuroprotective Agents; Neurotoxicity Syndromes; Phenobarbital; Random Allocation; Rats, Sprague-Dawley | 2019 |