phenobarbital has been researched along with diethylnitrosamine in 338 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 131 (38.76) | 18.7374 |
| 1990's | 112 (33.14) | 18.2507 |
| 2000's | 50 (14.79) | 29.6817 |
| 2010's | 43 (12.72) | 24.3611 |
| 2020's | 2 (0.59) | 2.80 |
| Authors | Studies |
|---|---|
| Pitot, HC | 1 |
| Barsness, L; Goldsworthy, T; Kitagawa, T; Pitot, HC | 1 |
| Arcos, JC; Argus, MF; Lai, DY | 1 |
| Ito, N; Miyata, Y; Murasaki, G; Nakanishi, K; Shinohara, Y; Tatematsu, M | 1 |
| Nishizumi, M | 2 |
| Kitagawa, T; Sugano, H | 1 |
| Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH | 1 |
| Archer, MC; Chau, IY; Dagani, D | 1 |
| Drevon, C; Kuroki, T; Montesano, R | 1 |
| Farwell, DC; Herbst, EJ; Nolan, CE | 1 |
| Gans, JH | 1 |
| Frantz, CN; Malling, HV | 1 |
| Gangolli, SD; Lake, BG; Lloyd, AG; Minski, MJ; Phillips, JC | 1 |
| Aoki, T; Hakoi, K; Ito, N; Kato, T; Ozaki, K; Sato, K; Tsuda, H; Uwagawa, S; Yamaguchi, S | 1 |
| Columbano, A; Coni, P; Curto, M; Faa, G; Giacomini, L; Ledda-Columbano, GM; Sarma, DS | 1 |
| Hayashi, Y; Maekawa, A; Matsushima, Y; Mitsumori, K; Ogasawara, H; Onodera, H | 1 |
| Jeney, A; Kovalszky, I; Lapis, K; Szeberenyi, S; Vincze, I; Zalatnai, A | 1 |
| Carter, HW; Carter, JH; Daniel, FB; DeAngelo, AB; Potter, CL; Richmond, RE | 1 |
| Daniel, FB; Lin, EL; Olson, GR; Reddy, TV; Stober, JA | 1 |
| Horie, S; Ohbu, M; Okudaira, M | 1 |
| Hendrich, S; Leveston, AO; Pitot, HC | 1 |
| Hayashi, Y; Maekawa, A; Matsushima, Y; Mitsumori, K; Onodera, H; Shibutani, M; Uneyama, C | 1 |
| Cho, KJ; Chung, HT; Jan, JJ; Lee, YS; Seo, JS | 1 |
| Aitio, ML; Arvela, P; Bartsch, H; Béréziat, JC; Hietanen, E | 1 |
| Duran, ME; Gázquez, A; Gómez, L; Masot, AJ; Redondo, E; Roncero, V | 1 |
| Frei, E; Schroth, P; Wiench, K; Wiessler, M | 1 |
| Amanuma, T; Denda, A; Konishi, Y; Maruyama, H; Tsujiuchi, T; Tsutsumi, M | 1 |
| Carmichael, WW; Fujiki, H; Ishikawa, T; Kohyama, K; Nishiwaki, S; Nishiwaki-Matsushima, R; Ohta, T; Suganuma, M | 1 |
| Kovatch, RM; Lijinsky, W; Thomas, BJ | 1 |
| Dragan, YP; Pitot, HC; Xu, YD | 1 |
| Davis, RA; Glauert, HP; Khoury, MM; Pereira, MA | 1 |
| Denda, A; Kinugasa, T; Konishi, Y; Matsuzaki, M; Nakae, D; Tsujii, T; Yoshiji, H | 1 |
| Zhao, QZ | 1 |
| Hasegawa, R; Ito, N; Ogawa, K; Wada, S; Yamaguchi, S | 1 |
| Klaunig, JE; Siglin, JC; Weghorst, CM | 1 |
| Meisner, L; Pitot, HC; Roloff, B; Sargent, LM; Sattler, CA; Sattler, GL; Xu, YH | 1 |
| Barrass, NC; Evans, JG; Phillimore, HE; Rumsby, PC | 1 |
| Appel, KE; Buchmann, A; Menden, M; Schwarz, M | 1 |
| Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Shirai, T; Takahashi, S; Yamaguchi, S | 1 |
| Iatropoulos, MJ; Tokumo, K; Williams, GM | 1 |
| Chen, ZY; Eaton, DL | 1 |
| Gullberg, D; Högberg, J; Rubin, K; Stenius, U | 1 |
| Campbell, HA; Hendrich, S; Maronpot, R; Pitot, HC; Sato, K; Sattler, GL; Xu, YH | 1 |
| Maronpot, R; Pitot, HC; Xu, YH | 1 |
| Beer, DG; Neveu, MJ | 1 |
| Hully, JR; Neveu, MJ; Paul, DL; Pitot, HC | 1 |
| Bentley, P; Bieri, F; Cruz-Orive, LM; Jack, EM; Muakkassah-Kelly, SF; Stäubli, W; Suter, J; Waechter, F | 1 |
| Duitsman, P; Hendrich, S; Jackson, A; Krueger, SK; Myers, RK | 1 |
| Jirtle, RL; Meyer, SA | 1 |
| Lapis, K; Lapsis, K; Rot, A; Sárosi, I; Zalatnai, A | 1 |
| Dragan, YP; Pitot, HC; Xu, YD; Young, T | 1 |
| Ding, LA | 1 |
| Denda, A; Kondoh, S; Konishi, Y; Maruyama, H; Nakae, D; Tsujiuchi, T; Tsutsumi, M | 1 |
| Li, S | 1 |
| Diwan, BA; Rice, JM; Ward, JM | 3 |
| Fukushima, S; Hagiwara, A; Hasegawa, R; Ito, N; Yamada, M | 1 |
| Kunz, W; Scholz, W; Schütze, K; Schwarz, M | 1 |
| Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM | 1 |
| Appelkvist, EL; Dallner, G; Kalén, A | 1 |
| Hasegawa, R; Ito, N; Ogiso, T; Tamano, S; Tatematsu, M | 1 |
| Yang, YP | 1 |
| Creasia, DA; Fullerton, FR; Hoover, K; Mikol, YB; Poirier, LA | 1 |
| de Gerlache, J; Deleener, A; Kirsch-Volders, M; Lans, M | 2 |
| Blanke, RV; Fitzgerald, R; Guzelian, PS; Sirica, AE; Wilkerson, CS; Wu, LL | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Mutai, M; Tsuda, H; Yamaguchi, S | 1 |
| Decker, RW; Magat, WJ; Malejka-Giganti, D | 1 |
| Asamoto, M; Hashimoto, Y; Ito, N; Kato, T; Masuko, T; Nagase, S; Tsuda, H | 1 |
| Donovan, PJ; Perantoni, AO; Rehm, S; Rice, JM | 1 |
| Dunn, T; Goodspeed, D; Hendrich, S; Maronpot, RR; Moran, S; Pitot, HC | 1 |
| Cattley, RC; Popp, JA | 1 |
| Denda, A; Eimoto, H; Kinugasa, T; Kitazawa, S; Konishi, Y; Takashima, Y; Tsujiuchi, T; Tsutsumi, M; Ura, H | 1 |
| Becker, FF | 2 |
| Kitagawa, T; Lee, GH; Nomura, K | 1 |
| Bauer-Hofmann, R; Buchmann, A; Mahr, J; Schwarz, M | 1 |
| Klaunig, JE; Pereira, MA; Weghorst, CM | 2 |
| Diwan, BA; Henneman, JR; Klaunig, JE; Lubet, RA; Nims, RW; Rice, JM; Ward, JM; Weghorst, CM | 1 |
| Glauert, HP; Hendrich, S; Pitot, HC | 1 |
| Bridges, JW; Greaves, P; Irisarri, E; Mompon, P; Monro, AM | 1 |
| Domingo, J; Estadella, MD; Pujol, MJ | 2 |
| Fukushima, S; Imaida, K; Ito, N; King, CM; Lee, MS; Ohshima, M; Shirai, T | 1 |
| Herren-Freund, SL; Pereira, MA | 1 |
| Goldsworthy, TL; Pitot, HC | 2 |
| Hirose, K; Hirose, M; Hosoda, K; Ito, N; Shirai, T | 1 |
| Hoekstra, WG; Laishes, BA; LeBoeuf, RA | 1 |
| Glauert, HP; Hanigan, M; Pitot, HC | 1 |
| Daino, L; Feo, F; Frassetto, S; Garcea, R; Pascale, R; Pirisi, L; Ruggiu, ME | 1 |
| Hanigan, MH; Pitot, HC | 1 |
| Glauert, HP; Pitot, HC; Schwarz, M | 1 |
| Greaves, P; Irisarri, E; Monro, AM | 1 |
| Glauert, HP; Pitot, HC | 1 |
| Davidson, M; Gregg, RG; Wilce, PA | 1 |
| Leach, MF; Lin, KH; Lindahl, R; Winters, AL | 1 |
| Herren-Freund, SL; Khoury, MM; Long, RE; Pereira, MA | 1 |
| de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H | 1 |
| Adams, T; Leonard, TB; Popp, JA | 1 |
| Bykorez, AI; Kononenko, LI; Vinarchuk, MP | 2 |
| Daino, L; Donaera, A; Feo, F; Garcea, R; Pascale, R; Pirisi, L | 1 |
| Campbell, HA; Glauert, HP; Goldsworthy, TL; Kennan, W; Maronpot, RR; Moran, S; Pitot, HC | 1 |
| Högberg, J; Stenius, U | 2 |
| Diwan, BA; Hu, H; Lubet, RA; Nims, RW; Rice, JM; Ward, JM | 2 |
| Klaunig, JE; Weghorst, CM | 1 |
| Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Pascale, R; Ruggiu, ME | 1 |
| Buchmann, A; Kunz, W; Oesch, F; Robertson, LW; Wolf, CR | 1 |
| Denda, A; Konishi, Y; Nakae, D; Shiraiwa, K; Takahashi, S; Tsutsumi, M; Uchida, K | 1 |
| Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM | 1 |
| Barbason, H; Brumioul, D; Lemaître, M; Verly, WG | 1 |
| Bykorez, AI; Grabovaia, AR; Kononenko, LI | 1 |
| Herren-Freund, SL; Klaunig, JE; Pereira, MA; Ruch, RJ | 1 |
| Evans, JG; Gangolli, SD; Lake, BG | 1 |
| Buchmann, A; Kunz, W; Oesch, F; Schmitt, R; Schwarz, M; Wolf, CR | 1 |
| Farber, E; Hayes, MA; Lee, G; Tatematsu, M | 1 |
| Katayama, K; Sato, T; Taki, T; Tsukidate, K; Yamada, K | 1 |
| Bykorez, AI; Khranovskaia, LN; Osipova, LA; Vinarchuk, MP | 1 |
| Hoover, KL; Poirier, LA; Shivapurkar, N | 1 |
| Diwan, BA; Hu, H; Ohshima, M; Rice, JM; Schuller, HM; Ward, JM | 1 |
| Aquino, T; Dorado, RD; Dytioco, S; Markell, N; Ooka, S; Porta, EA | 1 |
| Herren-Freund, SL; Long, RE; Pereira, MA | 1 |
| Fel', VIa; Khodosova, IA; Zakharova, NV | 1 |
| Barbason, H; Bouzahzah, B; Massart, S; Mormont, C | 1 |
| Anderson, LM; Diwan, BA; Hagiwara, A; Rice, JM; Ward, JM | 1 |
| Sivak, A; Tu, AS | 1 |
| Kikuchi, H; Watanabe, M | 2 |
| Diwan, BA; Dove, LF; Ohshima, M; Rice, JM; Ward, JM | 1 |
| Peraino, C; Vesselinovitch, SD | 1 |
| Diwan, BA; Ohshima, M; Rice, JM; Ward, JM | 1 |
| Driver, HE; McLean, AE | 1 |
| Della Porta, G; Dragani, TA; Galliani, G; Manenti, G | 1 |
| Abraham, R; Charles, AK; Timchalk, C | 1 |
| Dietz, D; Kornbrust, D | 1 |
| Kitagawa, T; Sugano, H; Watanabe, R | 1 |
| Campbell, HA; Goldsworthy, T; Pitot, HC; Poland, A | 1 |
| Lombardi, B; Shinozuka, H | 1 |
| Ford, JO; Pereira, MA | 1 |
| Katayama, S; Ohmori, T; Williams, GM | 1 |
| Campbell, HA; Laishes, BA; Pitot, HC; Potter, VR | 1 |
| Becker, FF; Stout, DL | 1 |
| Aust, SD; Goodman, JI; Jensen, RK; Sleight, SD; Trosko, JE | 1 |
| Jirtle, RL; Michalopoulos, G; Novicki, DL | 1 |
| Bentley, P; Bieri, F; Fröhlich, E; Stäubli, W; Waechter, F | 1 |
| Campbell, HA; Goldsworthy, T; Pitot, HC | 1 |
| Britt, AL; Herren-Freund, SL; Khoury, MM; Pereira, MA | 2 |
| Ito, N; Mera, Y; Moore, MA; Ogiso, T; Tsuda, H | 1 |
| Couri, D; Milks, MM | 1 |
| Fan, MC; Li, S; Li, SS; Liu, Y; Wang, MS | 1 |
| Baker, MT; Evans, JS; Holmes, D; Wade, AE | 1 |
| Lynch, P; Ohshima, M; Riggs, C; Ward, JM | 1 |
| Furukawa, F; Hayashi, Y; Kokubo, T; Takahashi, M; Toyoda, K | 1 |
| Kamiya, T; Ninomiya, Y; Sakamoto, M; Yanagi, S | 1 |
| Schuller, HM; Ward, JM | 1 |
| Chojnacki, T; Dallner, G; Edlund, C | 1 |
| Chieli, E; Malvaldi, G; Saviozzi, M | 1 |
| Johansen, MG; McGowan, JP; Shirachi, DY; Tu, SH | 1 |
| Furuya, K; Williams, GM | 1 |
| Diwan, BA; Lynch, PH; Ohshima, M; Rice, JM; Ward, JM | 1 |
| Fukushima, S; Hirose, M; Ito, N; Ogiso, T; Shirai, T; Tsuda, H | 1 |
| Goldsworthy, T; Moran, S; Pitot, HC; Sirica, AE; Weeks, J | 1 |
| Gel'shteĭn, VI; Kobliakov, VA; Koliada, AIu | 1 |
| Barbason, H; Betz, EH; Rassenfosse, C | 1 |
| Creasia, D; Lynch, P; Rice, JM; Riggs, C; Ward, JM | 1 |
| Farmer, PB; Smith, AG; White, IN | 1 |
| Gans, JH; Mulcahy, LS | 1 |
| Kunz, W; Schaude, G; Schwarz, M; Tennekes, H | 1 |
| Cameron, RG; Imaida, K; Ito, N; Tsuda, H | 1 |
| Lindahl, R | 1 |
| Gurkalo, VK | 1 |
| Sasaki, K; Yamamoto, N; Yanagi, S | 1 |
| Furukawa, K; Gotoh, M; Mochizuki, Y; Sawada, N | 1 |
| Cameron, R; Imaida, K; Ito, N | 1 |
| Butler, WH; Evans, JG; Pedrick, MS; Phillimore, HE; Rumsby, PC; Wright, V | 1 |
| Deguchi, T; Pitot, HC | 1 |
| Bishayee, A; Chatterjee, M | 1 |
| Jang, JJ; Kim, SH; Kim, TH; Lee, MS; Lee, YS | 1 |
| Diwan, BA; Henneman, JR; Rice, JM | 1 |
| Balansky, RM; Blagoeva, PM; De Flora, S; Mircheva, ZI | 1 |
| Daino, L; De Miglio, MR; Feo, F; Gaspa, L; Nufris, A; Pascale, R; Seddaiu, MA; Simile, MM | 1 |
| Merlino, GT; Tamano, S; Ward, JM | 1 |
| Crow, R; Dragan, YP; Hully, J; Mass, M; Pitot, HC | 1 |
| Laconi, E; Manjeshwar, S; Rajalakshmi, S; Rao, PM; Sarma, DS; Sheikh, A | 1 |
| Andersen, ME; Birnbaum, LS; Conolly, RB; Fox, TR; Goldsworthy, TL; Mills, JJ | 1 |
| Lapis, K; Zalatnai, A | 2 |
| Boyer, IJ; Chari, RS; Jirtle, RL; Reisenbichler, H | 1 |
| Klaunig, JE | 1 |
| Fukushima, S; Iwata, H; Morii, H; Nishisawa, Y; Otoshi, T; Takada, N | 1 |
| Dragan, YP; Pitot, HC; Sargent, L; Xu, YD; Xu, YH | 1 |
| Dragan, YP; Pitot, HC; Xu, YH | 1 |
| Leibold, E; Schwarz, LR | 1 |
| Gebhardt, R; Sirma, H; Stenbäck, F; Williams, GM | 1 |
| Davies, MJ; Evans, JG; Rumsby, PC | 1 |
| Devor, DE; Henneman, JR; Ward, JM; Weghorst, CM | 1 |
| Babcock, KL; Hertzberg, EL; Hully, JR; Neveu, MJ; Nicholson, BJ; Paul, DL; Pitot, HC | 1 |
| Glatt, H; Schwarz, M; Werle-Schneider, G | 1 |
| Castelain, P; Ghahroudi, MA; Kirsch-Volders, M; Van Goethem, F | 1 |
| Henneman, JR; Jang, JJ; Kurata, Y; Uno, H; Ward, JM | 1 |
| Pereira, MA | 1 |
| Stenius, U | 1 |
| Amanuma, T; Denda, A; Konishi, Y; Maruyama, H; Murata, Y; Tang, Q; Tsujiuchi, T; Tsutsumi, M | 1 |
| Boyer, IJ; De Souza, AT; Hankins, GR; Jirtle, RL; Mansbach, JM; Mills, JJ | 1 |
| Kawamori, T; Makita, H; Mori, H; Ohnishi, M; Okamoto, K; Sugie, S; Tanaka, T; Watanabe, T | 2 |
| Hendrich, S; Lee, KW; Murphy, PA; Wang, HJ | 1 |
| Högberg, J; Lennartsson, P; Martens, U; Stenius, U | 1 |
| Klaunig, JE; Kolaja, KL; Stevenson, DE; Walborg, EF | 2 |
| Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
| Mori, H; Okumura, A; Tanaka, T | 1 |
| Dragan, YP; Pitot, HC; Singh, J | 1 |
| Hara, Y; Kohri, T; Matsumoto, N; Okushio, K | 1 |
| Fukushima, S; Funae, Y; Hagiwara, A; Imaoka, S; Kitano, M; Matsuda, T; Shirai, T; Takesada, Y; Tamano, S | 1 |
| Baral, RN; Das, BR; Giri, RK | 1 |
| Kawamori, T; Makita, H; Mori, H; Nakamura, Y; Nakamura, YK; Ohnishi, M; Okamoto, K; Sugie, S; Tanaka, T; Tomita, I; Watanabe, T | 1 |
| Davis, CD; Santoni-Rugiu, E; Snyderwine, EG; Thorgeirsson, SS | 1 |
| Kim, HC; Lee, YS; Nishikawa, A | 1 |
| Honda, A; Kawabata, M; Okada, N; Yajima, N | 1 |
| Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H | 1 |
| Chen, HW; Ko, JJ; Lii, CK; Ou, CC; Sheen, LY | 1 |
| Futakuchi, M; Hasegawa, R; Ito, N; Lijinsky, W; Mizoguchi, Y; Shirai, T; Yamaguchi, T | 1 |
| Lee, GH; Ooasa, T; Osanai, M | 1 |
| Mori, H; Okamoto, K; Sugie, S; Tanaka, T; Ueda, F; Watanabe, T | 1 |
| Garberg, P; Grasl-Kraupp, B; Högberg, J; Thullberg, M | 1 |
| Bhaumik, M; Guttenplan, J; Harris, T; Johnson, L; Rogler, C; Stanley, P; Sundaram, S | 1 |
| Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM | 1 |
| Fukushima, S; Funae, Y; Hagiwara, A; Ichihara, T; Imaoka, S; Kitano, M; Matsuda, T; Shirai, T; Tamano, S; Wanibuchi, H | 1 |
| Hong, JT; Kim, DJ; Lee, KK | 1 |
| Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP | 1 |
| Barbason, H; Claustrat, B; Deprés-Brummer, P; Lévi, F; Reynes, M; van den Heiligenberg, S | 1 |
| Ando, J; Kudoh, K; Maekawa, A; Miyajima, K; Nakae, D; Shiraki, K; Takahashi, M; Yoshida, M | 1 |
| Bhattacharya, S; Chatterjee, M | 1 |
| Duc, NM; Ichiishi, E; Kasai, R; Konoshima, T; Murakami, T; Nishino, H; Takasaki, M; Tokuda, H; Yamasaki, K | 1 |
| Finnberg, N; Högberg, J; Stenius, U | 1 |
| Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T | 1 |
| Barbisan, LF; Fávero Salvadori, DM; Kaneno, R; Marchesan Rodrigues, MA; Spinardi-Barbisan, AL; Trindade Moreira, EL; Viana de Camargo, JL | 1 |
| Bhattacharyya, R; Bhaumik, M; Gong, S; Rogler, CE; Stanley, P; Yang, X | 1 |
| Bishayee, A; Chatterjee, M; Sarkar, A | 1 |
| Buchmann, A; Moennikes, O; Ott, T; Romualdi, A; Schwarz, M; Werringloer, J; Willecke, K | 1 |
| Basak, R; Chatterjee, M | 1 |
| Basak, R; Bhattacharya, R; Chatterjee, M | 1 |
| Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T | 1 |
| Anzano, M; Factor, VM; Flanders, K; Hahm, KB; Haines, DC; Im, YH; Jang, JJ; Kim, HT; Kim, IY; Kim, SJ; Sizeland, A; Thorgeirsson, SS | 1 |
| Eto, Y; Futagawa, Y; Ohashi, T; Okamoto, T; Shiba, H | 1 |
| Goto, K; Kobayashi, K; Kusakabe, M; Morohashi, T; Mutai, M; Okada, M; Sakairi, T; Sano, F; Sugimoto, J; Tsuchiya, T | 1 |
| Aydinlik, H; Buchmann, A; Moennikes, O; Nguyen, TD; Schwarz, M | 1 |
| Hirose, M; Kobayashi, T; Masutomi, N; Nishikawa, A; Shibutani, M; Takahashi, N; Uneyama, C | 1 |
| Chabicovsky, M; Grasl-Kraupp, B; Peter, B; Rossmanith, W; Schausberger, E; Schulte-Hermann, R | 1 |
| Buchmann, A; Gaunitz, F; Gebhardt, R; Kurek, R; Loeppen, S; Schneider, D; Schwarz, M | 1 |
| Sakthisekaran, D; Thirunavukkarasu, C | 3 |
| Azuine, MA; Ichiishi, E; Kapadia, GJ; Konoshima, T; Mukainake, T; Nishino, H; Okuda, Y; Sridhar, R; Takasaki, M; Tokuda, H; Tsuruta, A | 1 |
| Fukushima, S; Funae, Y; Imaoka, S; Kinoshita, A; Morimura, K; Shen, J; Wanibuchi, H; Wei, M | 1 |
| Rogler, CE; Stanley, P; Tang, J; Yang, X | 1 |
| Banakar, MC; Chakraborty, P; Chatterjee, M; Chattopadhyay, MB; Datta, S; Kannan, K; Paramasivan, SK; Thygarajan, E | 1 |
| Banu, SM; Padmavathi, R; Sakthisekaran, D; Selvendiran, K; Singh, JP | 1 |
| de Boer, J; Fairchild, D; Glickman, B; Johnson, A; Kanazawa, N; Mirsalis, JC; Nguyen, T; Shimon, JA; Winegar, RA | 1 |
| Chodon, D; Murugesh, N; Rajkapoor, B; Sakthisekaran, D | 1 |
| Bukowska, K; Bursch, W; Chabicovsky, M; Grasl-Kraupp, B; Schulte-Hermann, R; Taper, H; Wastl, U | 1 |
| Cardani, R; Zavanella, T | 1 |
| Bali, G; Sreepriya, M | 2 |
| Shahjahan, M; Shyamaladevi, CS; Vani, G | 1 |
| Asamoto, M; Hokaiwado, N; Ogawa, K; Shirai, T | 1 |
| Jagadeeswaran, R; Premkumar, K; Sakthisekaran, D; Thirunavukkarasu, C | 1 |
| Ferencz, V; Folhoffer, A; Gaál, J; Hegedus, D; Horváth, A; Horváth, C; Kári, B; Mészáros, S; Szalay, F; Wolf, Z | 1 |
| Baginskaia, NV; Il'nitskaia, SI; Kaledin, VI; Kholodar', AV; Obut, TA | 1 |
| Ariki, Y; Fukushima, S; Hidaka, T; Hosoe, K; Kato, M; Kitano, M; Morimura, K; Wada, J; Wanibuchi, H | 1 |
| Chakraborty, T; Chatterjee, A; Chatterjee, M; Saralaya, MG | 1 |
| Goodman, JI; Maronpot, RR; Negishi, M; Phillips, JM; Yamamoto, Y | 1 |
| Chakraborty, T; Chatterjee, A; Chatterjee, M; Rana, B; Shyamsundar, A; Swamy, AH | 1 |
| Hayakawa, A; Nagasaka, T; Nakao, A; Sakakima, Y | 1 |
| Bu, XY; Lou, YQ; Wang, X; Zhang, GL; Zhang, JJ; Zhao, X | 1 |
| Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M | 1 |
| Chakraborty, T; Chatterjee, A; Chatterjee, M; Damodaran, S; Rana, A; Srivastawa, S | 1 |
| Bhatnagar, D; Yadav, AS | 1 |
| Premkumar, K; Sakthisekaran, D; Sheriff, AK; Thirunavukkarasu, C | 1 |
| Bishayee, A; Dhir, N | 1 |
| Birchmeier, C; Borowiak, M; Buchmann, A; Knorpp, T; Marx-Stoelting, P; Schwarz, M | 1 |
| Fukushima, S; Inoue, M; Kakehashi, A; Wanibuchi, H; Wei, M | 1 |
| Burgoon, LD; Goodman, JI; Phillips, JM | 1 |
| Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D | 1 |
| Hidaka, T; Hosoe, K; Kawabe, M; Kitano, M; Nabae, K; Nakagawa, K | 1 |
| Barnes, KF; Bhatia, D; Bishayee, A; Carroll, RT; Darvesh, AS | 1 |
| Galle, PR; Hansen, T; Kanzler, S; Longerich, T; Maass, T; Mann, A; Schirmacher, P; Strand, D; Teufel, A; Thieringer, FR | 1 |
| Fukushima, S | 1 |
| Fukushima, S; Ishii, N; Kakehashi, A; Okazaki, E; Shibata, T; Tachibana, T; Wanibuchi, H; Wei, M | 1 |
| Braeuning, A; Buchmann, A; Rignall, B; Schwarz, M | 1 |
| Bishayee, A; Darvesh, AS; Folkesson, HG; Háznagy-Radnai, E; Hohmann, J; Mbimba, T; Sipos, P; Thoppil, RJ | 1 |
| Calvisi, DF | 1 |
| Hayashi, SM; Imaoka, M; Ishii, Y; Kuwata, K; Mitsumori, K; Morita, R; Ogawa, B; Shibutani, M; Shimamoto, K; Suzuki, K | 1 |
| Awale, P; Bhatia, D; Bishayee, A; Carroll, RT; Darvesh, AS; Geldenhuys, WJ; Mbimba, T | 1 |
| Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Oliveira, I; Ribeiro Pinto, LF | 1 |
| Coleman, RA; Depetrillo, MA; Ellis, JM; Malarkey, DE; Paul, DS; Singh, BP | 1 |
| Pichler, BJ; Rignall, B; Schmid, A; Schwarz, M | 1 |
| Liu, G; Sun, H; Wei, H; Yu, L | 1 |
| Awuah, PK; Misse, A; Monga, SP; Rhieu, BH; Singh, S | 1 |
| Banerjee, A; Gartel, AL; Halasi, M; Kabirov, K; Landolfi, J; Lyubimov, AV; Wang, M | 1 |
| Braeuning, A | 1 |
| Braeuning, A; Pichler, BJ; Schmid, A; Schwarz, M; Singh, Y | 1 |
| Chen, HL; Hu, WT; Lee, SK; Li, HC; Lo, SY; Ma, HC; Yang, CH | 1 |
| Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A | 2 |
| El-Kersh, MA; El-Rashidy, FH; Habashy, NH; Shaban, NZ | 1 |
| Agrawal, SS; Alhaider, AA; Saraswati, S | 1 |
| Jhala, M; Joseph, JP; Kumar, P; Raval, SK; Sadariya, KA | 1 |
| Hara, S; Hayashi, H; Mitsumori, K; Morita, R; Ogawa, T; Segawa, R; Shibutani, M; Suzuki, K; Takimoto, N | 1 |
| DE Stefano, J; Duan, T; Hsu, S; Khor, SC; Shen, T; Xu, LH; Xu, YY; Yang, J; Zheng, YF; Zhou, F; Zhu, XQ | 1 |
| Bader-Eldin, MM; El-Kersh, MA; Hamoda, AF; Kato, SA; Shaban, NZ | 1 |
| Akyuz, F; Aydın, O; Benkli, K; Burukoglu, D; Degirmenci, I; Ozbayer, CS; Ozden, H; Tekin, N; Ustuner, MC | 1 |
| Fukushima, S; Inboot, W; Punvittayagul, C; Taya, S; Wongpoomchai, R | 1 |
| Abe, M; Furukawa, S; Hagio, S; Hayashi, S; Kuroda, Y; Ogawa, I | 1 |
| Freiler, C; Grasl-Kraupp, B; Kainzbauer, E; Koudelka, H; Lorenz, O; Nejabat, M; Parzefall, W; Riegler, T; Schulte-Hermann, R | 1 |
| Hayashi, H; Kanki, M; Minami, K; Mitsumori, K; Morikawa, Y; Omura, K; Ono, A; Uehara, T; Urushidani, T; Yamada, H | 2 |
| Bian, H; Chen, ZN; He, F; Li, C; Lu, M; Wang, XL; Wu, J | 1 |
| Alvarado, TF; Delgado, E; Monga, SP; Nejak-Bowen, KN; Oertel, M; Okabe, H; Preziosi, M; Russell, JO; Zhang, Y | 1 |
| Bishayee, A; Farrag, AG; Hussein, UK; Mahmoud, HM | 1 |
| Fukushima, K; Fukushima, N; Hirane, M; Honoki, K; Ishii, S; Takahashi, K; Tomimatsu, A; Tsujiuchi, T | 1 |
| Abdel-Gawad, E; Awwad, S; El-Agamy, B; Kandil, E; Mohammed, M | 1 |
| Ahmed, KA; El Miniawy, HM; Khattab, MM; Mansour, SA | 1 |
| Hassan, ME; Mahmoud, AM; Mostafa-Hedeab, G; Zaki, AR | 1 |
| Dozmorov, M; Fisher, PB; Ghosh, S; Jariwala, N; Lai, Z; Mendoza, RG; Mukhopadhyay, ND; Robertson, CL; Sarkar, D; Subler, MA; Windle, JJ | 1 |
| Anderson, A; Bray, C; Calderon, R; Corr, SJ; Curley, S; Ho, J; Jain, S; Law, J; Nagaraj, A; Rios, J; Toombs, B; Ware, M | 1 |
| Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA | 1 |
| Ali, AAH; Hassan, SA; Jänicke, RU; Korf, HW; Pfeffer, M; Sohn, D; von Gall, C; Yassine, M | 1 |
| Bu, N; Jiang, Y; Li, S; Li, Y; Pan, K; Su, Y; Sun, H | 1 |
6 review(s) available for phenobarbital and diethylnitrosamine
| Article | Year |
|---|---|
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; Female; Inactivation, Metabolic; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Phenobarbital; Species Specificity | 1990 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Environment; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Histocytochemistry; Liver Neoplasms, Experimental; Male; Models, Biological; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344 | 1985 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Phenobarbital; Rats | 1985 |
Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms; Methyldimethylaminoazobenzene; Neoplasms, Experimental; Phenobarbital; Phenotype; Rats | 1982 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Hypertrophy; Liver; Liver Neoplasms; Microsomes, Liver; Neoplasms, Experimental; Organ Size; Oxygenases; Phenobarbital; Precancerous Conditions; Rats | 1982 |
Receptor-mediated toxicity and implications for risk assessment.
Topics: Animals; Cell Division; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene Expression Regulation; Growth Substances; Humans; Liver Neoplasms, Experimental; Models, Biological; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Risk Assessment | 1994 |
332 other study(ies) available for phenobarbital and diethylnitrosamine
| Article | Year |
|---|---|
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Hyperplasia; Liver; Liver Neoplasms; Mice; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats | 1977 |
Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms; Nitrosamines; Phenobarbital; Phenotype; Rats | 1978 |
Factors influencing the microsome- and mitochondria-catalyzed in vitro binding of diethylnitrosamine and N-nitrosopiperidine to deoxyribonucleic acid.
Topics: Animals; Cytosol; Diethylnitrosamine; DNA; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Nitrosamines; Phenobarbital; Piperidines; Rats | 1979 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlorocyclohexane; Hyperplasia; Liver; Liver Diseases; Male; Phenobarbital; Rats | 1979 |
Effect of phenobarbital, dichlorodiphenyltrichloroethane, and polychlorinated biphenyls on diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; DDT; Diethylnitrosamine; Drug Synergism; Enzyme Induction; Liver Neoplasms, Experimental; Male; Nitrosamines; Phenobarbital; Polychlorinated Biphenyls; Rats | 1979 |
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Nitrosamines; p-Dimethylaminoazobenzene; Phenobarbital; Precancerous Conditions; Rats | 1978 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosuppression Therapy; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Time Factors | 1975 |
Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Polychlorinated Biphenyls; Rats; Time Factors | 1976 |
Kinetic studies on the hepatic microsomal metabolism of dimethylnitrosamine, diethylnitrosamine, and methylethylnitrosamine in the rat.
Topics: Animals; Binding Sites; Binding, Competitive; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nitrosamines; Phenobarbital; Rats | 1978 |
Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines.
Topics: Acetonitriles; Animals; Azaguanine; Cell Line; Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Drug Resistance; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Rats; Salmonella typhimurium | 1977 |
Liver ornithine decarboxylase during phenobarbital promotion of nitrosamine carcinogenesis.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Ornithine Decarboxylase; Phenobarbital; Rats; Spermidine; Spermine | 1978 |
Diethylnitrosamine-induced changes in mouse liver morphology and function.
Topics: Animals; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Hexobarbital; Liver; Liver Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Time Factors | 1976 |
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Histidine; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Proadifen; Salmonella typhimurium; Time Factors; Valerates | 1975 |
Studies on the metabolism of diethylnitrosamine in the rat.
Topics: Age Factors; Animals; Carbon Dioxide; Carbon Radioisotopes; Diethylnitrosamine; Enzyme Inhibitors; Female; Male; Nitrosamines; Phenobarbital; Pyrazoles; Rats; Triazines | 1975 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Ethoxyquin; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glutathione Transferase; Isoenzymes; Liver Neoplasms, Experimental; Male; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Nitrates; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Administration Schedule; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
Quantitative image cytometry of hepatocytes expressing gamma-glutamyl transpeptidase and glutathione S-transferase in diethylnitrosamine-initiated rats treated with phenobarbital and/or phthalate esters.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transferase; Histocytochemistry; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Liver; Male; Phenobarbital; Phthalic Acids; Rats; Rats, Inbred F344 | 1992 |
Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.
Topics: Analysis of Variance; Animals; Body Weight; Chloroform; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Drinking; gamma-Glutamyltransferase; Glutathione Transferase; Humans; Liver; Male; Microsomes, Liver; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
Mouse and rat strain variations in sensitivity to N-nitroso-diethylamine, hereditary transmission of the trait and the effect of 3-tert-butyl-4-hydroxyanisole on sensitivity.
Topics: Animals; Anticarcinogenic Agents; Butylated Hydroxyanisole; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Genetic Predisposition to Disease; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Phenobarbital; Rats; Species Specificity; Survival Rate; Time Factors | 1992 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms; Organ Size; Ovariectomy; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1992 |
[Dose-response relationship of promotion by phenobarbital in rat two-stage hepatocarcinogenesis].
Topics: Administration, Oral; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1991 |
Lung adenoma development and NK activity in mice treated with multiple carcinogens.
Topics: Adenoma; Animals; Diethylnitrosamine; Female; Killer Cells, Natural; Lung Neoplasms; Methylnitrosourea; Mice; Phenobarbital; Random Allocation; Urethane | 1992 |
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital.
Topics: Animals; Antipyrine; Debrisoquin; Diethylnitrosamine; Liver; Male; Microsomes, Liver; Neoplasms, Experimental; Organ Size; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism; Warfarin | 1992 |
Experimental induction of biliary cystadenoma in rats: a morphological study.
Topics: Animals; Biliary Tract Neoplasms; Cystadenoma; Diethylnitrosamine; Female; Liver; Male; Microscopy, Electron; Phenobarbital; Rats; Rats, Wistar | 1992 |
1-C-glucuronidation of N-nitrosodiethylamine and N-nitrosomethyl-n-pentylamine in vivo and in primary hepatocytes from rats pretreated with inducers.
Topics: Animals; Aroclors; Chromatography, High Pressure Liquid; Diethylnitrosamine; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Organ Specificity; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Urinary Bladder | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Mercaptopurine; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1992 |
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers, Tumor; Cyanobacteria; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Male; Marine Toxins; Microcystins; Peptides, Cyclic; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy; Leukemia, Experimental; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Methapyrilene; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Evaluation, Preclinical; Female; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Glutathione Transferase; Liver Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344; Tamoxifen | 1991 |
Screen of five alkyl carbamates for initiating and promoting activity in rat liver.
Topics: Animals; Carbamates; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Lethal Dose 50; Liver; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Iron; Iron Deficiencies; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1991 |
[The expression of alpha 1-inhibitor 3 gene and some changes of its structure in rat hepatomas].
Topics: Acute-Phase Proteins; Animals; Diethylnitrosamine; DNA Transposable Elements; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Methylation; Phenobarbital; Polymorphism, Restriction Fragment Length; Protease Inhibitors; Rats; Rats, Inbred Strains | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Glutathione Transferase; Hepatectomy; Injections, Intraperitoneal; Liver; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1991 |
Role of hepatocyte proliferation in alpha-hexachlorocyclohexane and phenobarbital tumor promotion in B6C3F1 mice.
Topics: Animals; Carcinogens; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA Replication; Female; Hexachlorocyclohexane; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital | 1991 |
Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver.
Topics: Animals; Carcinogens; Cell Division; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorders; Diethylnitrosamine; Female; Karyotyping; Liver; Phenobarbital; Ploidies; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Translocation, Genetic | 1992 |
Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Blotting, Southern; Codon; Diethylnitrosamine; DNA; Gene Expression; Genes, ras; Immunoblotting; Liver Neoplasms, Experimental; Methylation; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Phenobarbital; RNA, Neoplasm | 1991 |
Effect of varying the concentration of phenobarbital and its duration of treatment on the evolution of carcinogen induced enzyme-altered foci in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression Regulation, Neoplastic; Hepatitis B Surface Antigens; Hepatitis B virus; Liver; Liver Neoplasms; Mice; Mice, Transgenic; Phenobarbital | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital | 1991 |
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alkylation; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hepatectomy; Hyperplasia; Liver; Male; Oxazines; Phenobarbital; Rats; Rats, Inbred F344; Stimulation, Chemical | 1991 |
gamma-Glutamyltranspeptidase-positive rat hepatocytes are protected from GSH depletion, oxidative stress and reversible alterations of collagen receptors.
Topics: Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Diethylnitrosamine; Diquat; Female; gamma-Glutamyltransferase; Glutathione; Hydrogen Peroxide; Hydroquinones; Ketones; Kinetics; Liver; Maleates; Phenobarbital; Rats; Receptors, Cell Surface; Receptors, Collagen; Selenium; Sodium Selenite; Vitamin K | 1990 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Sex Factors | 1990 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathione Transferase; Liver Neoplasms, Experimental; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1990 |
Proto-oncogene and gap-junction protein expression in rodent liver neoplasms.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Hepatectomy; Intercellular Junctions; Liver Neoplasms, Experimental; Neoplasm Proteins; Phenobarbital; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1990 |
Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Connexins; Diethylnitrosamine; Ethylnitrosourea; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Glutathione Transferase; Liver; Liver Neoplasms; Membrane Proteins; Phenobarbital; Polychlorinated Dibenzodioxins; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values | 1990 |
Ultrastructural changes in chemically induced preneoplastic focal lesions in the rat liver: a stereological study.
Topics: Animals; Animals, Newborn; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Microscopy, Electron; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1990 |
Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Analysis of Variance; Animals; Body Weight; Butylated Hydroxyanisole; Diethylnitrosamine; Eating; Liver Neoplasms, Experimental; Organ Size; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Vitamin E | 1991 |
Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
Topics: Animals; Binding, Competitive; Cell Transformation, Neoplastic; Diethylnitrosamine; Epidermal Growth Factor; Liver; Liver Neoplasms, Experimental; Phenobarbital; Protein Kinase C; Rats; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 1991 |
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1991 |
The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Experimental; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344 | 1991 |
[Inhibition effect of epicatechin on phenobarbitol-induced proliferation precancerous liver cells].
Topics: Animals; Catechin; Diethylnitrosamine; Flavonoids; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; Tea | 1990 |
Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis.
Topics: Animals; Benzamides; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Luminol; Male; Phenobarbital; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred F344 | 1990 |
[Expression of cellular oncogenes during hepatocarcinogenesis in rats].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Liver; Male; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Inbred F344 | 1990 |
Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules.
Topics: Acridines; Animals; Cytochrome P-450 Enzyme System; Diagnostic Imaging; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Luminescent Measurements; Luminol; Microsomes, Liver; NADP; Oxygen; Oxygenases; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Disease Models, Animal; DNA, Neoplasm; Female; Liver Neoplasms; Male; Phenobarbital; Ploidies; Prohibitins; Rats | 1990 |
The effects of inducers of the endoplasmic reticulum, peroxisomes and mitochondria on the amounts and synthesis of ubiquinone in rat liver subcellular membranes.
Topics: Animals; Cholesterol, Dietary; Cholestyramine Resin; Chromatography, High Pressure Liquid; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Dolichols; Endoplasmic Reticulum; Intracellular Membranes; Liver; Methylcholanthrene; Mevalonic Acid; Microbodies; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Ubiquinone | 1990 |
Correlation between medium-term liver bioassay system data and results of long-term testing in rats.
Topics: Animals; Butylated Hydroxyanisole; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Enzyme Induction; Ethionine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Methylnitronitrosoguanidine; Phenobarbital; Rats; Rats, Inbred F344; Thioacetamide; Time Factors | 1990 |
[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Female; Gene Expression; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Nucleic Acid Hybridization; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344 | 1990 |
The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital.
Topics: Animals; Choline; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Organ Size; Phenobarbital | 1990 |
Increased silver stainability of metaphase chromosomes from rat hepatocytes during in vivo hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Chromosomes; Diethylnitrosamine; Liver Neoplasms; Metaphase; Phenobarbital; Rats; Silver; Staining and Labeling | 1985 |
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
Topics: Animals; Chlordecone; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Insecticides; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; Reference Values; Sex Factors | 1989 |
Promotion of malignant 'embryonal' liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Crosses, Genetic; Diethylnitrosamine; Female; Hemangiosarcoma; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Phenobarbital; Reference Values; Teratoma | 1989 |
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344; Thioacetamide | 1989 |
Modifications of hepatic microsomal 9-oxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Castration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; Glucuronidase; Glucuronosyltransferase; Hydroxylation; Male; Microsomes, Liver; NADH Dehydrogenase; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Immunohistochemistry; Isoenzymes; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
Comparative transplacental carcinogenesis by directly acting and metabolism-dependent alkylating agents in rodents and nonhuman primates.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Carcinogens; Choriocarcinoma; Diethylnitrosamine; Erythrocebus patas; Ethylnitrosourea; Female; Male; Neoplasms, Experimental; Neoplasms, Germ Cell and Embryonal; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Uterine Neoplasms | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltransferase; Gene Expression Regulation; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Molecular Sequence Data; Naphthols; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; RNA, Messenger | 1989 |
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Phenobarbital; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344; Time Factors | 1989 |
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Ethoxyquin; Flavonoids; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Quercetin; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1989 |
Tumor phenotype and susceptibility to progression as an expression of subpopulations of initiated murine cells.
Topics: alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Susceptibility; Drug Interactions; Female; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital; Phenotype; Pregnancy; Time Factors | 1985 |
Comparative study of diethylnitrosamine-initiated two-stage hepatocarcinogenesis in C3H, C57BL and BALB mice promoted by various hepatopromoters.
Topics: Animals; Clofibrate; Diethylnitrosamine; Ethinyl Estradiol; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital; Species Specificity | 1989 |
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Genes, ras; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Phenobarbital; Polymerase Chain Reaction; Precancerous Conditions; RNA, Messenger | 1989 |
Strain differences in hepatic tumor promotion by phenobarbital in diethylnitrosamine- and dimethylnitrosamine-initiated infant male mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital; Reference Values; Species Specificity | 1989 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diazepam; Diethylnitrosamine; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Oxidoreductases; Phenobarbital | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; Liver Neoplasms, Experimental; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
A cytochemical study of the livers of rats treated with diethylnitrosamine/phenobarbital, with benzidine/phenobarbital, with phenobarbital, or with clofibrate.
Topics: Administration, Oral; Animals; Benzidines; Clofibrate; Diethylnitrosamine; Drug Interactions; Glucose-6-Phosphatase; Injections, Intraperitoneal; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Cell phenotype instability in preneoplastic foci of rat liver.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Liver; Liver Neoplasms, Experimental; Male; Nucleotidases; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred Strains | 1988 |
Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1985 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Nitrosamines; Phenobarbital; Phenotype; Rats | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Organ Size; p-Dimethylaminoazobenzene; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Selenium | 1985 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Polyamines; Putrescine; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Spermidine; Spermine | 1985 |
Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1985 |
The phenotypic stability of altered hepatic foci: effect of the short-term withdrawal of phenobarbital and of the long-term feeding of purified diets after the withdrawal of phenobarbital.
Topics: Animals; Diet; Dietary Fats; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Phenobarbital; Phenotype; Rats; Substance Withdrawal Syndrome | 1986 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Histocytochemistry; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatty Liver; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Organ Size; Phenobarbital; Rats | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxymethylglutaryl CoA Reductases; Liver; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Karyotyping; Liver Neoplasms, Experimental; Methylcholanthrene; NADP; Neoplasm Transplantation; Organoids; Phenobarbital; Phenotype; Rats; Tyrosine Transaminase | 1986 |
The effect of single versus split doses of diethylnitrosamine on the induction of gamma-glutamyltranspeptidase-foci in the livers of adult and juvenile rats.
Topics: Aging; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; gamma-Glutamyltransferase; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; Propionates; Rats; Rats, Inbred Strains | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Nitrobenzenes; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344 | 1986 |
[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1987 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1987 |
A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Dioxins; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Liver; Liver Neoplasms; Methods; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1987 |
gamma-Glutamyltranspeptidase-conferred resistance to hydroquinone induced GSH depletion and toxicity in isolated hepatocytes.
Topics: Animals; Cell Survival; Cells, Cultured; Diethylnitrosamine; Drug Resistance; gamma-Glutamyltransferase; Glutathione; Hydroquinones; In Vitro Techniques; Liver; Methionine; Phenobarbital; Rats | 1988 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Kidney Neoplasms; Liver Neoplasms; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urea | 1989 |
Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender.
Topics: Animals; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; Precancerous Conditions; Sex Factors | 1989 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1987 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Liver; Liver Neoplasms, Experimental; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Rats | 1986 |
Possible model of liver carcinogenesis using inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Male; NAD; Phenobarbital; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred F344 | 1986 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Phenobarbital | 1988 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hydantoins; Liver; Liver Neoplasms, Experimental; Male; Mephenytoin; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms | 1988 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; Triiodothyronine | 1988 |
Action of phenobarbital given to rats together with diethylnitrosamine on the O6-ethylguanine content of liver DNA.
Topics: Animals; Diethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
[The use of a primary culture of liver cells from rat embryos subjected to transplacental exposure to N-nitrosodiethylamine for the study of hepatocarcinogenesis promoters].
Topics: Animals; Carcinogens; Cells, Cultured; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Phenobarbital; Rats; Tetradecanoylphorbol Acetate | 1987 |
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Phenobarbital; Species Specificity | 1986 |
The histopathology and biochemistry of phenobarbitone-induced liver nodules in C3H mice.
Topics: Animals; Diethylnitrosamine; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1987 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Phenobarbital; Precancerous Conditions; Rats | 1987 |
Influences of diethylnitrosamine on longevity of surrounding hepatocytes and progression of transplanted persistent nodules during phenobarbital promotion of hepatocarcinogenesis.
Topics: Animals; Aroclors; Cell Survival; Chlorodiphenyl (54% Chlorine); Diethylnitrosamine; Female; Liver; Liver Neoplasms; Male; Neoplasm Transplantation; Phenobarbital; Rats; Rats, Inbred F344 | 1987 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital; Sexual Maturation | 1987 |
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mannosyltransferases; Methyldimethylaminoazobenzene; Microsomes, Liver; Phenobarbital; Polyisoprenyl Phosphates; Rats; Rats, Inbred F344 | 1987 |
[Characteristics of hepatocarcinogenesis after single exposure of synchronized cells of the regenerating liver to N-nitrosodiethylamine and subsequent administration of phenobarbital].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mitosis; Phenobarbital; Rats | 1987 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung Neoplasms; Male; Methionine; Phenobarbital; Prohibitins; Rats; Rats, Inbred F344; Weaning | 1986 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diazepam; Diethylnitrosamine; Enzyme Induction; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Organ Size; Oxazepam; Phenobarbital; Time Factors | 1986 |
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylhexyl Phthalate; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; Phthalic Acids; Plasticizers; Rats; Skin Neoplasms | 1986 |
Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
Topics: Animals; Diethylnitrosamine; Female; Glucans; Glucose; Hepatectomy; Kidney Neoplasms; Liver Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
[Detection of cells resistant to the cytotoxic action of CCl4 in rat hepatocyte populations following a single exposure to diethylnitrosamine and subsequent injections of phenobarbital].
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Drug Resistance; Histocytochemistry; Liver; Male; Mitochondria, Liver; Phenobarbital; Rats; Succinate Dehydrogenase; Time Factors | 1986 |
Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.
Topics: Animals; Diethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mitotic Index; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters.
Topics: Aminopyrine N-Demethylase; Animals; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mesocricetus; Methylazoxymethanol Acetate; Mice; Phenobarbital; Rats; Rats, Inbred F344 | 1986 |
Use of rodent hepatocytes for metabolic activation in transformation assays.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Liver; Methylcholanthrene; Mice; Phenobarbital; Rats; Species Specificity | 1985 |
Effect of phenobarbital on the content of RNA polymerase B regulatory factors during diethylnitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; Phenobarbital; Rats; Transcription Factors, General; Transcriptional Elongation Factors | 1985 |
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Neoplasms, Experimental; Organ Size; Phenobarbital; Rats; Rats, Inbred F344 | 1985 |
An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Butylated Hydroxyanisole; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatectomy; Liver Neoplasms, Experimental; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1985 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Organ Size; Phenobarbital; Species Specificity; Structure-Activity Relationship | 1986 |
Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pyridines | 1985 |
Effect of phenobarbital on the activity of RNA polymerase II during diethylnitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains; RNA Polymerase II | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Histocytochemistry; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; Insecticides; Liver; Liver Neoplasms; Male; Mirex; Neoplasm Proteins; Phenobarbital; Precancerous Conditions; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; DDT; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Liver; Male; Methyl Methanesulfonate; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Induction of gamma-glutamyl transpeptidase activity by dietary phenobarbital in "spontaneous" hepatic tumors of C3H mice.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Phenobarbital | 1980 |
Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Dioxins; Drug Synergism; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Liver Neoplasms; Nitrosamines; Phenobarbital; Phenotype; Polychlorinated Dibenzodioxins; Rats | 1980 |
Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.
Topics: Animals; Body Weight; Choline; Cocarcinogenesis; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Histocytochemistry; Liver; Male; Nitrosamines; Organ Size; Phenobarbital; Prohibitins; Rats | 1980 |
Short-term in vivo initiation/promotion bioassay for hepatocarcinogens.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Interactions; gamma-Glutamyltransferase; Hepatectomy; Liver Neoplasms; Male; Phenobarbital; Rats | 1980 |
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344 | 1981 |
Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver.
Topics: Animals; Computers; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Hepatectomy; Liver; Mathematics; Models, Biological; Phenobarbital; Rats | 1982 |
Occurrence of progressive DNA damage coincident with the appearance of foci of altered hepatocytes.
Topics: Animals; Diethylnitrosamine; DNA; Female; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.
Topics: Acyltransferases; Animals; Biphenyl Compounds; Carcinogens; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Neoplasms, Experimental; Phenobarbital; Polybrominated Biphenyls; Rats; Rats, Inbred Strains; Transglutaminases | 1982 |
Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol.
Topics: Animals; Cell Line; Cell Separation; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Neoplasm Transplantation; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344; Tyrosine Transaminase | 1983 |
Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver; Nafenopin; Nitrosamines; Organ Size; Phenobarbital; Propionates; Rats | 1984 |
The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats | 1984 |
Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats.
Topics: Animals; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1984 |
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Phenobarbital; Phenotype; Rats; Rats, Inbred F344; Stimulation, Chemical; Time Factors | 1984 |
[Histochemical appearance of gamma-glutamyltranspeptidase in the rat liver after transplacental exposure to diethylnitrosamine and postnatal administration of phenobarbital].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Histocytochemistry; Hyperplasia; Liver; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1984 |
The direct and indirect effects of promoters may depend upon the nature of the initiated cell.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Mice; Phenobarbital | 1983 |
Trichloroethylene effects on the formation of enzyme-altered foci in rat liver.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Trichloroethylene | 1984 |
Effects of strain, sex, route of administration and partial hepatectomy on the induction by chemical carcinogens of gamma-glutamyltranspeptidase foci in rat liver.
Topics: Animals; Carcinogens; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Injections, Intraperitoneal; Liver; Male; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains; Staining and Labeling; Time Factors | 1983 |
[Studies on the mechanism of carcinogenesis. V. Differential changes in activities of enzymes involved in ornithine metabolism in early phase of hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.
Topics: Aniline Compounds; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Dimethylnitrosamine; Ethylmorphine; Female; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organ Size; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Thiamine; Thiamine Deficiency | 1983 |
Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
Topics: Animals; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; Male; Mice; Mice, Inbred Strains; Phenobarbital; Phthalic Acids | 1984 |
[Establishment of test methods for examining promoters of hepatocarcinogenesis--promoting effects of phenobarbital, butylated hydroxytoluene and barbital].
Topics: Animals; Barbital; Barbiturates; Butylated Hydroxytoluene; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344 | 1984 |
Decrease in L-type pyruvate kinase activity in rat liver by some promoters of hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride Poisoning; Carcinogens; Diethylnitrosamine; Isoenzymes; Isomerism; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Phenobarbital; Phenytoin; Pyruvate Kinase; Rats; Rats, Inbred Strains; Saccharin | 1984 |
Quantitative electron microscopic analysis of changes in peroxisomes and endoplasmic reticulum induced in mice during hepatocarcinogenesis by diethylnitrosamine promoted by di(2-ethylhexyl)phthalate or phenobarbital.
Topics: Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Endoplasmic Reticulum; Liver Neoplasms, Experimental; Male; Mice; Microbodies; Microscopy, Electron; Mitochondria, Liver; Phenobarbital; Phthalic Acids | 1984 |
Separation of dolichol and dolichyl-P in microsomal and lysosomal compartments of hepatocytes.
Topics: Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Kinetics; Liver; Lysosomes; Male; Microsomes, Liver; Phenobarbital; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains | 1983 |
Promotive effects of thiobenzamide on liver carcinogenesis.
Topics: Amides; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains; Thioamides | 1983 |
Tumorigenic effect of sodium arsenite in rat kidney.
Topics: Animals; Arsenic; Arsenites; Body Weight; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains; Sodium Compounds | 1983 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1984 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Nitrosamines; Organ Size; Phenobarbital; Time Factors | 1984 |
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experimental; Nephrectomy; Nitrosamines; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred F344; Saccharin | 1981 |
[Localization of cytochrome P-450PB in the rat liver and primary liver tumors of different histological structure after administration of inductor aroclor 1254].
Topics: Adenocarcinoma; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Immunoenzyme Techniques; Liver; Liver Neoplasms; Neoplasms, Experimental; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1982 |
Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver Neoplasms, Experimental; Male; Mitosis; Mitotic Index; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplasia; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Phthalic Acids | 1983 |
Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Mice, Inbred C57BL; Nitrosamines; Phenobarbital; Porphyrins; Protoporphyrins | 1983 |
The fidelity of mouse liver mitochondrial DNA polymerase following long-term administration of carbon tetrachloride, diethylnitrosamine, or phenobarbital.
Topics: Animals; Carbon Tetrachloride; Chromatography, DEAE-Cellulose; Diethylnitrosamine; DNA-Directed DNA Polymerase; Male; Mice; Mitochondria, Liver; Nitrosamines; Phenobarbital | 1983 |
Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Bile Acids and Salts; Carcinogens; Cortisone; Dexamethasone; Diethylnitrosamine; Ethinyl Estradiol; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Testosterone | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine; Enzyme Induction; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Phenotype; Precancerous Conditions; Rats | 1982 |
The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine.
Topics: 2-Acetylaminofluorene; Animals; Behavior, Animal; Brain; Dextroamphetamine; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Rats; Sympathetic Nervous System; Synapses | 1980 |
Induction by phenobarbital of ornithine decarboxylase activity in rat liver after initiation with diethylnitrosamine.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Enzyme Induction; Liver; Male; Nitrosamines; Ornithine Decarboxylase; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Dose-dependent enhancing effect of phenobarbital on hepatocarcinogenesis initiated by diethylnitrosamine in the rat.
Topics: Animals; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats | 1981 |
Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Hyperplasia; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats | 1981 |
Growth characteristics and Ha-ras mutations of cell cultures isolated from chemically induced mouse liver tumours.
Topics: Animals; Cell Division; Codon; Diethylnitrosamine; Eosine Yellowish-(YS); Genes, ras; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Nude; Mutation; Neoplasm Transplantation; Phenobarbital; Staining and Labeling; Tumor Cells, Cultured | 1994 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Gene Expression; Genes, myc; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; Food, Fortified; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Rats; Rats, Sprague-Dawley; Vanadium | 1995 |
Development of altered hepatocyte foci by separate and combined treatments with radiation and diethylnitrosamine in neonatal rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Female; Gamma Rays; Glutathione Transferase; Liver; Liver Neoplasms; Neoplasms, Radiation-Induced; Neutrons; Organ Size; Phenobarbital; Placenta; Pregnancy; Radiation Dosage; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Further evidence for promoter-dependent development of hepatoblastoma in the mouse.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatoblastoma; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital | 1995 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Female; Liver Neoplasms, Experimental; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains; Survival; Theophylline; Tretinoin | 1994 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, ras; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar; Regression Analysis; RNA, Messenger; S-Adenosylmethionine; Time Factors; Transcription, Genetic | 1994 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Mice; Mice, Transgenic; Phenobarbital; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Transforming Growth Factor alpha | 1994 |
Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Models, Biological; Phenobarbital; Rats; Rats, Inbred F344 | 1994 |
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Topics: Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Mitosis; Models, Biological; Orotic Acid; Phenobarbital; Rats; Rats, Inbred F344 | 1994 |
Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model.
Topics: Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Hepatectomy; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors | 1994 |
Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Down-Regulation; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; Phenobarbital; Rats; Rats, Inbred F344; Receptors, Transforming Growth Factor beta; RNA, Messenger; RNA, Neoplasm | 1994 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; Precancerous Conditions; Time Factors | 1993 |
22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver medium-term bioassay.
Topics: Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors | 1994 |
The initiation-promotion-progression model of rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Benzene; Biomarkers, Tumor; Cells, Cultured; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Glutathione Transferase; Karyotyping; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Ploidies; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Glutathione Transferase; Isoenzymes; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Pregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar | 1993 |
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Administration Schedule; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors | 1993 |
Screening for p53 mutations in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Diethylnitrosamine; DNA, Neoplasm; DNA, Single-Stranded; Exons; Genes, p53; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Phenobarbital; Polymerase Chain Reaction; Polymorphism, Genetic | 1994 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Female; Incidence; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Phenobarbital | 1994 |
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; Diethylnitrosamine; Gap Junction beta-1 Protein; Gene Expression; In Situ Hybridization; Liver; Liver Neoplasms, Experimental; Phenobarbital; Polychlorinated Dibenzodioxins; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1994 |
Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Phenobarbital; Pyrenes; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfotransferases | 1993 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitotic Index; Phenobarbital; Rats; Rats, Wistar | 1993 |
Alterations in populations of GST-p-immunoreactive single hepatocytes and hepatocellular foci after a single injection of N-nitrosodiethylamine with or without phenobarbital promotion in male F344/NCr rats.
Topics: Animals; Body Weight; Cells, Cultured; Diethylnitrosamine; Glutathione Transferase; Liver; Male; Organ Size; Phenobarbital; Placenta; Rats; Rats, Inbred F344; Time Factors | 1993 |
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Phenobarbital; Sensitivity and Specificity; Species Specificity | 1993 |
Different inhibition of DNA synthesis by transforming growth factor beta and phenobarbital on GST-P-positive and GST-P-negative hepatocytes.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Diethylnitrosamine; DNA; Female; Glutathione Transferase; Liver; Phenobarbital; Rats; Transforming Growth Factor beta | 1993 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Lipoxygenase Inhibitors; Liver Neoplasms, Experimental; Male; Phenobarbital; Phospholipases A; Phospholipases A2; Precancerous Conditions; Quercetin; Rats; Rats, Inbred F344 | 1993 |
Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Receptors, Transforming Growth Factor beta; RNA, Messenger | 1996 |
Chemopreventive effects of taurine on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Placenta; Rats; Rats, Inbred F344; Taurine | 1996 |
Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathione Peroxidase; Glycine max; Histocytochemistry; Isoflavones; Liver; Liver Neoplasms, Experimental; Organ Size; Phenobarbital; Plant Extracts; Rats; Rats, Inbred F344 | 1995 |
Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnitrosamine; Female; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Phenobarbital; Rats; Rats, Sprague-Dawley | 1996 |
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1996 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eosinophils; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Organ Size; Phenobarbital; Precancerous Conditions | 1996 |
Simultaneous measurement of unscheduled and replicating DNA synthesis by means of a new cell culture insert DNA retention method: rapid induction of replicating DNA synthesis in response to genotoxic carcinogens.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Autoradiography; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA; DNA Replication; Hydroxyurea; Liver; Male; Mutagens; Nafenopin; Phenobarbital; Rats; Scintillation Counting | 1996 |
Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.
Topics: Animals; Caprylates; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Mestranol; Mitotic Index; Phenobarbital; Placenta; Pregnancy; Rats; Triglycerides | 1996 |
Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diethylnitrosamine; Drug Screening Assays, Antitumor; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Plant Extracts; Precancerous Conditions; Rats; Rats, Inbred F344 | 1996 |
Inhibitory effect of chlorophyllin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Chlorophyllides; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1996 |
Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay.
Topics: Animals; Biological Assay; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1996 |
Induction of lung carcinogenesis in AKR-mice by N-nitrosodiethylamine/phenobarbitone, associated with high expression of c-myc and c-jun oncoproteins.
Topics: Animals; Carcinogens; Diethylnitrosamine; Lung Neoplasms; Male; Mice; Mice, Inbred AKR; Neoplasm Proteins; Neoplasms, Experimental; Phenobarbital; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc | 1997 |
Suppressive effects of S-methyl methanethiosulfonate on promotion stage of diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Diethylnitrosamine; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Methyl Methanesulfonate; Ornithine Decarboxylase; Phenobarbital; Rabbits; Rats; Rats, Inbred F344 | 1997 |
Hepatic tumor induction in c-myc mono-transgenic and TGF-alpha/c-myc double-transgenic mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; Phenobarbital; Proto-Oncogene Proteins c-myc; Quinolines; Transforming Growth Factor alpha | 1997 |
Enhancing effects of phenobarbital and 3-methylcholanthrene on GST-P-positive liver cell foci development in a new medium-term rat liver bioassay using D-galactosamine.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Body Weight; Carcinogens; Diet; Diethylnitrosamine; Galactosamine; Glutathione Transferase; Injections, Intraperitoneal; Liver; Liver Neoplasms; Liver Regeneration; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Rats, Inbred F344 | 1997 |
Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; DNA; Drug Synergism; Lac Operon; Liver; Male; Mice; Mice, Transgenic; Mutagens; Mutation; Organ Size; Phenobarbital | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Female; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Phenobarbital; Plants, Medicinal; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Corn oil enhances gamma-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Carcinogens; Corn Oil; Dietary Fats, Unsaturated; Diethylnitrosamine; Dinoprost; Fatty Acids; Female; Fish Oils; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Phenobarbital; Phospholipids; Rats; Rats, Sprague-Dawley; Vitamin E | 1997 |
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Topics: Animals; Carcinogens; Carcinoma, Transitional Cell; Diethylnitrosamine; Ethylnitrosourea; Male; Methylnitrosourea; Mutagens; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344; Survival Rate; Urinary Bladder Neoplasms | 1998 |
Mechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.
Topics: Adenoma; Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Division; Diethylnitrosamine; Immunohistochemistry; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2 | 1998 |
Suppressive effect of irsogladine maleate on diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in male F344 rats.
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Glutathione Transferase; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors; Triazines | 1998 |
Changes in liver fatty acid-binding protein in rat enzyme-altered foci.
Topics: Animals; Antibody Specificity; Carcinogens; Carrier Proteins; Diethylnitrosamine; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Hepatectomy; Immune Sera; Liver; Myelin P2 Protein; Nafenopin; Neoplasm Proteins; Nerve Tissue Proteins; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Sprague-Dawley | 1998 |
Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression.
Topics: Acetylglucosamine; Animals; Carcinogens; Diethylnitrosamine; Disease Progression; Female; Genetic Vectors; Liver Neoplasms, Experimental; Male; Mice; N-Acetylglucosaminyltransferases; Neoplasm Proteins; Phenobarbital; Polysaccharides | 1998 |
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diethylnitrosamine; Disease Progression; Disease Susceptibility; Enzyme Induction; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mixed Function Oxygenases; Phenobarbital; Precancerous Conditions; RNA, Messenger | 1998 |
Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Glutathione Transferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Transforming Growth Factor alpha; Transforming Growth Factor beta | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; Glutathione Transferase; Injections, Intraperitoneal; Liver Neoplasms; Male; Mutagens; Organ Size; Phenobarbital; Precancerous Conditions; Quinolines; Rats; Rats, Inbred F344 | 1998 |
Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Chick Embryo; Colonic Neoplasms; Dicarboxylic Acids; Diethylnitrosamine; Drug Combinations; Enzyme Inhibitors; Liver Neoplasms; Mice; Mice, Inbred BALB C; Phenobarbital; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rats; Rats, Wistar; Tumor Cells, Cultured | 1999 |
Phenobarbital-induced cytoplasmic accumulation of beta1-integrin in rat liver enzyme altered foci; an immunohistological study.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Carcinogens; Cytoplasm; Diethylnitrosamine; Female; Glutathione Transferase; Immunohistochemistry; Integrin beta1; Liver; Liver Neoplasms, Experimental; Phenobarbital; Pregnancy; Rats; Rats, Sprague-Dawley | 1998 |
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Temperature; Body Weight; Carcinogens; Circadian Rhythm; Diethylnitrosamine; Laparotomy; Light; Liver; Liver Neoplasms, Experimental; Male; Melatonin; Motor Activity; Phenobarbital; Random Allocation; Rats; Rats, Wistar; Survival Rate | 1999 |
Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Anti-Infective Agents; Carcinogenicity Tests; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Deoxyguanosine; Diethylnitrosamine; Fluoroquinolones; Immunohistochemistry; Liver; Liver Neoplasms; Male; Mice; Phenobarbital; Proliferating Cell Nuclear Antigen; Quinolizines; Steroid Hydroxylases | 1999 |
Inhibitory effect of Trianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diethylnitrosamine; Drinking Behavior; Eating; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 1999 |
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Female; Focal Nodular Hyperplasia; Ginsenosides; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Mice, Inbred SENCAR; Nitrates; Nitro Compounds; Panax; Papilloma; Phenobarbital; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vietnam | 1999 |
Xenobiotics modulate the p53 response to DNA damage in preneoplastic enzyme-altered foci in rat liver; effects of diethylnitrosamine and phenobarbital.
Topics: Animals; Blotting, Western; Body Weight; Carcinogens; Cell Count; Diethylnitrosamine; DNA Damage; Female; Glutathione Peroxidase; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Phenobarbital; Precancerous Conditions; Precipitin Tests; Pregnancy; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53; Xenobiotics | 2000 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver Neoplasms; Male; Mice; Microscopy, Electron; Phenobarbital; Polymerase Chain Reaction | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; Concanavalin A; Diethylnitrosamine; Flow Cytometry; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Spleen; T-Lymphocyte Subsets; Tissue Distribution | 2000 |
New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice.
Topics: Alleles; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Diethylnitrosamine; Disease Progression; Excitatory Amino Acid Antagonists; Exons; Gene Deletion; Genotype; Liver; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; N-Acetylglucosaminyltransferases; Organ Size; Phenobarbital; Phenotype; Promoter Regions, Genetic; Proteins; Transcription, Genetic | 2000 |
Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; beta Carotene; Carcinogens; Diethylnitrosamine; Excitatory Amino Acid Antagonists; Incidence; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tretinoin | 2000 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synergism; Female; Gap Junction beta-1 Protein; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Size; Phenobarbital; Precancerous Conditions | 2000 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Interactions; Glutathione Transferase; Hepatectomy; Hepatocytes; Liver Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Vanadium; Water Supply | 2000 |
1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis.
Topics: Animals; Calcitriol; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Liver; Liver Neoplasms; Male; Microscopy, Electron; Phenobarbital; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Nucleus; Diethylnitrosamine; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Liver Neoplasms; Male; Models, Chemical; Neoplasms; Nucleolus Organizer Region; Organ Size; Phenobarbital; Plant Extracts; Rats; Rats, Inbred F344; Time Factors | 2001 |
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Gene Dosage; Genes, cdc; Genetic Predisposition to Disease; Heterozygote; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Pregnancy; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Topics: Adenoviridae; Alkylating Agents; Animals; Anticonvulsants; beta-Galactosidase; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Injections, Intra-Arterial; Iodized Oil; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Wistar | 2001 |
Immunohistochemical characterization of hepatoblastomas in B6C3F1 mice treated with diethylnitrosamine and sodium phenobarbital.
Topics: Albumins; Alkylating Agents; alpha-Fetoproteins; Animals; Diethylnitrosamine; Immunohistochemistry; Keratins; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; Random Allocation; S100 Proteins; Vimentin | 2001 |
Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors.
Topics: Animals; Base Sequence; beta Catenin; Carcinogens; Cell Division; Clone Cells; Cytoskeletal Proteins; Diethylnitrosamine; DNA Mutational Analysis; DNA, Neoplasm; Genes, ras; Immunohistochemistry; Liver Neoplasms, Experimental; Mice; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Phenobarbital; Polymerase Chain Reaction; Selection, Genetic; Trans-Activators | 2001 |
Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay.
Topics: Animals; Base Sequence; Biological Assay; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation; Hepatectomy; Liver; Male; Molecular Sequence Data; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Inbred F344 | 2002 |
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Follistatin; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Nafenopin; Phenobarbital; Rats; Reference Values; RNA, Messenger; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2002 |
Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.
Topics: Animals; beta Catenin; Cytoskeletal Proteins; Diethylnitrosamine; Glutamate-Ammonia Ligase; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenobarbital; Trans-Activators; Transcriptional Activation; Up-Regulation | 2002 |
Sodium selenite, dietary micronutrient, prevents the lymphocyte DNA damage induced by N-nitrosodiethylamine and phenobarbital promoted experimental hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Dietary Supplements; Diethylnitrosamine; DNA Damage; Free Radicals; Humans; Lipid Peroxidation; Liver Neoplasms, Experimental; Lymphocytes; Male; Micronutrients; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Sodium Selenite | 2003 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Hydroxylamines; Indoles; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Phenobarbital; Plant Extracts; Plant Roots; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2003 |
Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors.
Topics: Animals; Biomarkers; Blood Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoproteins; Hexosamines; Hexoses; Liver; Liver Neoplasms, Experimental; Male; N-Acetylneuraminic Acid; Phenobarbital; Rats; Rats, Wistar; Serum Albumin; Serum Globulins; Sodium Selenite; Survival Analysis | 2003 |
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Apoptosis; Cell Division; Cytochrome P-450 Enzyme System; Deoxyguanosine; Diethylnitrosamine; DNA Damage; DNA-Formamidopyrimidine Glycosylase; DNA, Neoplasm; Electron Spin Resonance Spectroscopy; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Neoplastic; Glutamate Decarboxylase; Glutathione Transferase; Liver Neoplasms, Experimental; Male; N-Glycosyl Hydrolases; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2003 |
Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III.
Topics: Acetylglucosamine; Animals; Apoptosis; Carbohydrate Sequence; Carcinogens; Cell Division; Diethylnitrosamine; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Hepatectomy; Hepatocytes; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Phenobarbital; Vascular Endothelial Growth Factor A | 2003 |
Effect of dietary selenite on N-nitrosodiethylamine-induced and phenobarbital promoted multistage hepatocarcinogenesis in rat: reflection in some minerals.
Topics: Animals; Antineoplastic Agents; Carcinogens; Diet; Diethylnitrosamine; Iron; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Wistar; Sodium Selenite | 2003 |
1alpha, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Carcinogens; Comet Assay; Diet; Diethylnitrosamine; DNA Damage; Glutathione Transferase; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Phenobarbital; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vitamin D | 2004 |
Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Diethylnitrosamine; Flavonoids; Kidney; Lipid Peroxidation; Liver; Liver Neoplasms; Male; Phenobarbital; Phytotherapy; Plants, Medicinal; Rats; Rats, Wistar | 2004 |
Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.
Topics: Animals; Carcinogens; Clone Cells; Diethylnitrosamine; Female; Gene Frequency; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Mice; Mice, Transgenic; Mutation; Oxazepam; Phenobarbital | 2005 |
Chemoprevention of N-nitrosodiethylamine induced phenobarbitol promoted liver tumors in rat by extract of Indigofera aspalathoides.
Topics: Animals; Chemoprevention; Diethylnitrosamine; Drug Synergism; Indigofera; Liver Neoplasms, Experimental; Male; Phenobarbital; Plant Extracts; Plant Stems; Rats; Rats, Wistar | 2005 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Phenobarbital; Precancerous Conditions; Species Specificity | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta-1; Time Factors | 2005 |
Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzoquinones; Curcuma; Curcumin; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Disease Models, Animal; Enzymes; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Plant Extracts; Precancerous Conditions; Rats; Solanum; Thiobarbituric Acid Reactive Substances | 2005 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Connexins; Diethylnitrosamine; Disease Susceptibility; Enzyme Induction; Gap Junction beta-1 Protein; Gap Junctions; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mutation; Phenobarbital; Precancerous Conditions; Rats; Time Factors | 2005 |
The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels.
Topics: alpha-Fetoproteins; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Polyamines; Rats; Rats, Wistar; Sodium Selenite | 2005 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Liver Diseases; Male; Phenobarbital; Rats; Rats, Inbred F344 | 2005 |
Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Benzoquinones; Blood Cell Count; Carcinogens; Curcumin; Diethylnitrosamine; Drug Synergism; Glutathione; Hematopoiesis; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar | 2006 |
[Effect of phenobarbital and thyroxine on hepatocarcinogenesis initiated in mice by nitrosoethylurea and diethylnitrosamine].
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Ethylnitrosourea; Female; Hypnotics and Sedatives; Leukemia; Lung Neoplasms; Male; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Phenobarbital; Thyroxine | 2005 |
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Glutathione S-Transferase pi; Hepatectomy; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Transforming Growth Factor alpha | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosine; Diethylnitrosamine; Disease Models, Animal; DNA Damage; Elements; Liver; Liver Neoplasms, Experimental; Male; Metallothionein; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrometry, X-Ray Emission; Vanadium | 2006 |
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; Diethylnitrosamine; DNA Methylation; DNA, Neoplasm; Electrophoresis, Capillary; GC Rich Sequence; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Phenobarbital; Polymerase Chain Reaction; Precancerous Conditions; Receptors, Cytoplasmic and Nuclear; Time Factors; Transcription Factors | 2007 |
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Diethylnitrosamine; DNA Damage; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Random Allocation; Rats; Rats, Sprague-Dawley; Vanadium | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Diet; Diethylnitrosamine; Drug Synergism; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Vitamin K 2 | 2007 |
Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats.
Topics: Animals; Anticarcinogenic Agents; Berberine; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Diethylnitrosamine; Hepatocytes; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Nitric Oxide Synthase Type II; Phenobarbital; Rats; Rats, Sprague-Dawley | 2008 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms; Male; Models, Biological; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Sex Characteristics; Substrate Specificity | 2007 |
Cell proliferation and hepatocarcinogenesis in rat initiated by diethylnitrosamine and promoted by phenobarbital: potential roles of early DNA damage and liver metallothionein expression.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Carcinogens; Cell Proliferation; Copper; Diethylnitrosamine; DNA Damage; DNA Helicases; Ki-67 Antigen; Liver; Liver Neoplasms; Male; Metallothionein; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrophotometry, Atomic; Zinc | 2007 |
Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Erythrocytes; Glutathione; Glutathione Transferase; Illicium; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Plant Extracts; Rats; Rats, Wistar | 2007 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosamine; DNA Breaks, Double-Stranded; Drinking; Feeding Behavior; Glutathione Peroxidase; Liver; Liver Function Tests; Liver Neoplasms; Male; Organ Size; Phenobarbital; Rats; Rats, Wistar; Selenium; Serum Albumin; Sodium Selenite | 2008 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drug Screening Assays, Antitumor; Eating; Female; Immunohistochemistry; Liver Neoplasms, Experimental; Organ Size; Phenobarbital; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2009 |
Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.
Topics: Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Glutamate-Ammonia Ligase; Liver; Liver Neoplasms; Male; Mice; Mice, Knockout; Organ Size; Phenobarbital; Phenotype; Proto-Oncogene Proteins c-met; Signal Transduction; Time Factors | 2009 |
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Histones; Immunohistochemistry; Keratin-18; Keratin-8; Liver Neoplasms, Experimental; Male; Phenobarbital; Phosphorylation; Polymerase Chain Reaction; Rats; Rats, Inbred F344; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Up-Regulation | 2009 |
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; Diethylnitrosamine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Liver Neoplasms; Mice; Mice, Inbred C3H; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Phenobarbital; Precancerous Conditions; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2009 |
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Erythrocyte Membrane; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Lipid Peroxides; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Triterpenes; Ursolic Acid | 2009 |
Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Functional Food; Glutathione Transferase; Glycyrrhiza; Liver; Liver Neoplasms; Male; Phenobarbital; Phenols; Phytotherapy; Plant Preparations; Rats; Rats, Inbred F344; Triglycerides | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Hyperplasia; Inflammation; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oxidative Stress; Phenobarbital; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Messenger; Stilbenes; Tyrosine | 2010 |
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Blotting, Western; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibroblast Growth Factors; Humans; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; Phenobarbital; Platelet Endothelial Cell Adhesion Molecule-1; Proto-Oncogene Proteins c-sis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A | 2011 |
Carcinogenic risk assessment: are there dose thresholds for carcinogens?
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Damage; Glutathione Transferase; Intestinal Neoplasms; Liver Neoplasms, Experimental; Male; Mutagenicity Tests; Phenobarbital; Rats; Rats, Inbred F344; Risk Assessment | 2010 |
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; Mitochondria; Phenobarbital; Precancerous Conditions; Prohibitins; Rats; Rats, Inbred F344; Repressor Proteins; Septins; Signal Transduction | 2011 |
Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; DNA Mutational Analysis; Immunohistochemistry; Liver Neoplasms; Mice; Mice, Knockout; Phenobarbital; Polymorphism, Restriction Fragment Length | 2011 |
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Chemoprevention; Diethylnitrosamine; Down-Regulation; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Plant Extracts; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Ribes; Up-Regulation | 2011 |
Of mice and men: the nonrandom genomic instability in hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Genes, myc; Genomic Instability; Humans; Liver Neoplasms; Mice; Phenobarbital | 2011 |
Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; Constitutive Androstane Receptor; Diethylnitrosamine; Drinking Water; Glutathione Transferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Quercetin; Rats; Rats, Inbred F344; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Steroid Hydroxylases | 2011 |
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Cytokines; Diethylnitrosamine; Female; Gene Expression Regulation; Liver; Liver Neoplasms, Experimental; Phenobarbital; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Messenger; Stilbenes | 2012 |
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Death; Cells, Cultured; Chromosome Aberrations; Cocarcinogenesis; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Female; Hepatocytes; Micronuclei, Chromosome-Defective; Mitotic Index; Mutagens; Phenobarbital; Rats; RNA, Messenger; Steroid Hydroxylases; Up-Regulation | 2011 |
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Genetic Predisposition to Disease; Glycerol-3-Phosphate O-Acyltransferase; Hepatocytes; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; Organ Size; Phenobarbital; PPAR alpha; RNA, Messenger; Statistics, Nonparametric | 2012 |
Quantitative analysis of the growth kinetics of chemically induced mouse liver tumors by magnetic resonance imaging.
Topics: Animal Use Alternatives; Animals; Cocarcinogenesis; Diethylnitrosamine; Early Detection of Cancer; Imaging, Three-Dimensional; Liver; Liver Neoplasms, Experimental; Magnetic Resonance Imaging, Cine; Male; Mice; Mice, Inbred C3H; Phenobarbital; Reproducibility of Results; Tumor Burden | 2012 |
A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Biphenyl Compounds; Body Weight; Cell Line; Diethylnitrosamine; Histocytochemistry; Liver Function Tests; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Phenobarbital; Proliferating Cell Nuclear Antigen | 2012 |
β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; Hepatocytes; Immunohistochemistry; Ligands; Liver Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenobarbital; Receptor, Platelet-Derived Growth Factor alpha | 2012 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Neoplasms; Mice; Phenobarbital; Pyrazines; Thiostrepton | 2012 |
The connection of β-catenin and phenobarbital in murine hepatocarcinogenesis: a critical discussion of Awuah et al., PLoS ONE 7(6):e39771, 2012.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver Neoplasms, Experimental; Phenobarbital | 2013 |
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Topics: Acetaminophen; Animals; beta Catenin; Carcinogens; Cell Proliferation; Cytochrome P-450 CYP2E1; Diethylnitrosamine; Dose-Response Relationship, Drug; Hepatocytes; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mutation; Phenobarbital | 2013 |
Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Body Weight; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; GABA Modulators; Gene Expression Profiling; Hepacivirus; Humans; Liver; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Organ Size; Phenobarbital; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-myc; Viral Core Proteins | 2013 |
Enhanced liver tumor promotion activity in rats subjected to combined administration of phenobarbital and orphenadrine.
Topics: Animals; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Drug Combinations; Drug Synergism; Enzyme Induction; Liver Neoplasms; Male; Microsomes, Liver; Orphenadrine; Oxidative Stress; Phenobarbital; Rats; Rats, Inbred F344; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2013 |
Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats.
Topics: Animals; Caspase 3; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; DNA Fragmentation; Glutathione; Glutathione Peroxidase; Humans; Lipid Peroxidation; Liver; Lythraceae; Male; Oxidative Stress; Phenobarbital; Plant Oils; Protective Agents; Rats; Rats, Sprague-Dawley; Seeds; Superoxide Dismutase | 2013 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemical; Diethylnitrosamine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Induction; Glutathione S-Transferase pi; Hepatocytes; Liver Neoplasms; Male; Microsomes, Liver; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2013 |
Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cyclin D1; Diethylnitrosamine; Female; Gene Expression Regulation; Immunohistochemistry; Lipid Peroxidation; Liver Neoplasms, Experimental; Phenobarbital; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Strychnine; Vascular Endothelial Growth Factor A | 2013 |
Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Medicine, Ayurvedic; Milk; Nuts; Phenobarbital; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Semecarpus | 2013 |
Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Indoles; Liver Neoplasms; Male; NAD(P)H Dehydrogenase (Quinone); Phenobarbital; Rats; Rats, Inbred F344 | 2014 |
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver; Liver Cirrhosis; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Polyphenols; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Solubility; Tea | 2014 |
Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats.
Topics: Animals; Beverages; Caspase 3; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; Liver; Lythraceae; Male; Oxidative Stress; Phenobarbital; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2014 |
Apoptotic effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Fragmentation; Gold; Liver; Male; Phenazines; Phenobarbital; Rats; Rats, Sprague-Dawley; Toxicity Tests, Acute | 2014 |
Cleistocalyx nervosum extract ameliorates chemical-induced oxidative stress in early stages of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Diethylnitrosamine; Immunoenzyme Techniques; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Plant Extracts; Precancerous Conditions; Rats; Rats, Wistar; Syzygium | 2014 |
Repeated dose liver micronucleus assay using adult mice with multiple genotoxicity assays concurrently performed as a combination test.
Topics: Animals; Cisplatin; Comet Assay; Diethylnitrosamine; Liver; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Mutagenicity Tests; Phenobarbital; Risk Assessment; Time Factors | 2014 |
Superoxide deficiency attenuates promotion of hepatocarcinogenesis by cytotoxicity in NADPH oxidase knockout mice.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; Female; Liver; Liver Neoplasms, Experimental; Macrophages; Male; Mice, Knockout; Monocytes; NADPH Oxidases; Organ Size; Phenobarbital; Superoxides; Survival Analysis | 2015 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms; Male; Methapyrilene; Mutagenicity Tests; Oxidative Stress; Phenobarbital; Rats, Sprague-Dawley; Thioacetamide | 2014 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Gene Expression; Glutathione Transferase; Liver; Liver Neoplasms; Male; Phenobarbital; Rats, Sprague-Dawley | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression; Hepatic Stellate Cells; Immunohistochemistry; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; Neovascularization, Pathologic; Phenobarbital; Platelet Endothelial Cell Adhesion Molecule-1 | 2015 |
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Mutational Analysis; DNA, Neoplasm; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Immunohistochemistry; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mutation; Oligonucleotides; Phenobarbital; Tumor Cells, Cultured | 2015 |
Chemoprevention of Diethylnitrosamine-Initiated and Phenobarbital-Promoted Hepatocarcinogenesis in Rats by Sulfated Polysaccharides and Aqueous Extract of Ulva lactuca.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Plant Extracts; Polysaccharides; Rats; Rats, Sprague-Dawley; Time Factors; Ulva | 2015 |
Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells.
Topics: Animals; Carcinogens; Cell Line; Cell Movement; Clofibrate; Diethylnitrosamine; Epithelial Cells; Gene Expression Regulation; Liver Neoplasms, Experimental; Okadaic Acid; Phenobarbital; Rats; Rats, Inbred F344; Receptors, Lysophosphatidic Acid | 2016 |
Therapeutic role of a synthesized calcium phosphate nanocomposite material on hepatocarcinogenesis in rats.
Topics: Animals; Calcium Phosphates; Diethylnitrosamine; DNA Fragmentation; Enzymes; Interferon-gamma; Interleukin-2; Liver; Liver Neoplasms, Experimental; Male; Malondialdehyde; Microscopy, Electron, Scanning; Nanocomposites; Phenobarbital; Rats, Wistar; Tumor Necrosis Factor-alpha; X-Ray Diffraction | 2016 |
In vivo antitumour potential of camel's milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Camelus; Carcinoma, Hepatocellular; Cisplatin; Diethylnitrosamine; Glutathione S-Transferase pi; Kidney; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Milk; Nephritis, Interstitial; Phenobarbital; Rats, Wistar; Serum Albumin; Superoxide Dismutase; Time Factors | 2017 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammation; Liver; Liver Neoplasms, Experimental; Male; Neovascularization, Pathologic; NF-E2-Related Factor 2; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Signal Transduction; Terpenes; Vesicular Transport Proteins | 2017 |
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotaxis; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Hepatocytes; Inflammation; Liver Neoplasms; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; Phenobarbital; Risk Factors; RNA-Binding Proteins; RNA, Small Interfering; Tumor Microenvironment | 2018 |
Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Synergism; Female; Injections, Intraperitoneal; Liver Neoplasms, Experimental; Phenobarbital; Swine; Swine, Miniature | 2018 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Humans; Hydroxides; Hydroxybenzoates; Liver Neoplasms, Experimental; Mice; Nanoparticles; Phenobarbital | 2019 |
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Topics: Activity Cycles; Animals; Behavior, Animal; Biomarkers; Carcinoma, Hepatocellular; Chronotherapy; Circadian Rhythm; Corticosterone; Diethylnitrosamine; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Liver Neoplasms, Experimental; Locomotion; Male; Mice, Inbred C57BL; Mice, Transgenic; Period Circadian Proteins; Phenobarbital; Phosphorylation; Suprachiasmatic Nucleus; Time Factors | 2021 |
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Fruit; Gene Expression Regulation, Neoplastic; Inflammation; Liver; Liver Neoplasms; Male; Morus; Phenobarbital; Polysaccharides; Rats, Sprague-Dawley; RNA, Messenger | 2021 |