phenobarbital has been researched along with desipramine in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (52.94) | 18.7374 |
| 1990's | 6 (11.76) | 18.2507 |
| 2000's | 11 (21.57) | 29.6817 |
| 2010's | 7 (13.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jonsson, J | 1 |
| Keim, KL; Sigg, EB | 1 |
| Evans, DB; Liu, SJ; Wang, RI | 2 |
| Davis, CM; Fenimore, DC; Meyer, CJ | 1 |
| Breyer-Pfaff, U; Jahns, I; Spribille, T | 1 |
| Liu, SJ; Wang, RI | 1 |
| Cinicola, DP; Esposito, FM; Winek, CL | 1 |
| Brossier, P; Mariet, F | 1 |
| Kitteringham, NR; Park, BK; Riley, RJ; Roberts, P | 1 |
| Hanano, M; Iga, T; Lin, TH; Sawada, Y; Sugiyama, Y | 1 |
| Dailey, JW; Jobe, PC | 1 |
| Passananti, GT; Vessell, ES | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Kaniike, K; Kurogochi, Y | 1 |
| Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS | 1 |
| Orrenius, S; Schenkman, JB; von Bahr, C | 1 |
| Bellward, GD; Black, NB; Dayton, PG; O'Brien, L; Perel, JM | 1 |
| Hitomi, M; Kumada, S; Kumadaki, N | 1 |
| Alexanderson, B; Azarnoff, DL; Orrenius, S; Sjoqvist, F; von Bahr, C | 1 |
| Cosmides, GJ | 1 |
| Nakazawa, K | 1 |
| Bickel, MH; Minder, R | 1 |
| Staudinger, H; Zubrzycki, Z | 1 |
| Anton-Tay, F; Axelrod, J; Wurtman, RJ | 1 |
| Milner, G | 1 |
| Bhargava, KP; Dhawan, KN; Saxena, RC | 1 |
| Breyer-Pfaff, U; Brinkschulte, M | 1 |
| Oliver, SR; Shrewsbury, RP; White, LG | 1 |
| Avenoso, A; Campo, GM; Caputi, AP; Perucca, E; Spina, E | 1 |
| Commissaris, RL; Fontana, DJ; McMiller, LV | 1 |
| Murray, M; Trieu, L | 1 |
| Cantú, MD; Carrilho, E; Lacerda, CA; Lanças, FM; Queiroz, ME; Toso, DR | 1 |
3 review(s) available for phenobarbital and desipramine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Utility of clinical chemical determinations of drug concentrations in biological fluids.
Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramine; Dicumarol; Drug Antagonism; Drug Synergism; Ethanol; Female; Fluorometry; Half-Life; Humans; Iatrogenic Disease; Male; Mental Disorders; Metabolism; Methods; Middle Aged; Morphine; Nortriptyline; Nystagmus, Pathologic; Pharmaceutical Preparations; Pharmacogenetics; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Pregnancy; Smoking; Spectrophotometry; Twins; Ultraviolet Rays | 1971 |
1 trial(s) available for phenobarbital and desipramine
| Article | Year |
|---|---|
Phenobarbital induces the 2-hydroxylation of desipramine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Desipramine; Enzyme Induction; Epilepsy; Half-Life; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Polymorphism, Genetic | 1996 |
47 other study(ies) available for phenobarbital and desipramine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
On the aromatic hydroxylation of amphetamine in rat liver microsomes and perfused liver preparations: effects of long-term administration.
Topics: Administration, Oral; Amphetamines; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Desipramine; Fenfluramine; Hydroxylation; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Perfusion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Plasma corticosterone and brain catecholamines in stress: effect of psychotropic drugs.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain Chemistry; Catecholamines; Chlorpromazine; Corticosterone; Desipramine; Diazepam; Dopamine; Haloperidol; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Pargyline; Phenobarbital; Prohibitins; Psychotropic Drugs; Rats; Stress, Physiological; Telencephalon | 1977 |
Correlation of urinary excretion of methadone metabolites with methadone metabolism and analgesia in the rat.
Topics: Analgesics; Animals; Biotransformation; Desipramine; Diazepam; Drug Interactions; Male; Methadone; Phenobarbital; Rats; Reaction Time; Time Factors; Tissue Distribution | 1978 |
Determination of drugs in plasma by high-performance thin-layer chromatography.
Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Desipramine; Humans; Imipramine; Nortriptyline; Phenobarbital; Phenytoin; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1978 |
Determination of urinary excretion of a methadone metabolite as an indirect measurement of methadone metabolism in the rat.
Topics: Animals; Desipramine; Liver; Male; Methadone; Phenobarbital; Rats; Time Factors | 1978 |
Influence of phenobarbital on the distribution and elimination of desmethylimipramine in the rat.
Topics: Animals; Blood Proteins; Desipramine; Drug Interactions; Kinetics; Male; Phenobarbital; Protein Binding; Rats; Tissue Distribution | 1978 |
Increased analgesia and alterations in distribution and metabolism of methadone by desipramine in the rat.
Topics: Analgesia; Animals; Brain; Desipramine; Drug Synergism; In Vitro Techniques; Kidney; Lethal Dose 50; Liver; Lung; Male; Methadone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Reaction Time; Time Factors | 1975 |
The stability of several compounds in formalin fixed tissues and formalin-blood solutions.
Topics: Carbon Monoxide; Carboxyhemoglobin; Cyanides; Desipramine; Diazepam; Drug Stability; Embalming; Fixatives; Formaldehyde; Humans; Liver; Phenobarbital; Phenytoin; Postmortem Changes | 1990 |
A new powerful association for immunoassay: organometallic label conjugated to solvent separation method.
Topics: Desipramine; Immunoassay; Molecular Structure; Organometallic Compounds; Phenobarbital; Radioimmunoassay; Solvents | 1990 |
Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Amitriptyline; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Desipramine; Dibenzoxazepines; Enzyme Induction; Humans; Imipramine; Injections, Intraperitoneal; Male; Mianserin; Mice; Mice, Inbred CBA; Microsomes, Liver; Phenobarbital; Phenytoin | 1990 |
Effect of phenobarbitone on the distribution and elimination of imipramine in rats.
Topics: Animals; Desipramine; Half-Life; Imipramine; Kinetics; Male; Phenobarbital; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease Models, Animal; Epilepsy; Ethosuximide; Imipramine; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Metabolic interconversions and binding of imipramine, imipramine-N-oxide, and desmethylimipramine in rat liver slices.
Topics: Animals; Cytosol; Dealkylation; Desipramine; Female; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Sex Factors; Temperature; Time Factors | 1971 |
[Effect of psychotropic drugs on the K + -dependent phosphatase activity in guinea pig brain microsomes].
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlordiazepoxide; Chlorpromazine; Desipramine; Diazepam; Guinea Pigs; Histamine; Hydroxyzine; Imipramine; Meprobamate; Microsomes; Morphine; Nialamide; Phenelzine; Phenobarbital; Phenoxybenzamine; Phosphoric Monoester Hydrolases; Pilocarpine; Potassium; Procaine; Reserpine; Tranquilizing Agents | 1972 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium | 1974 |
Effect of phenobarbital and 3,4-benzpyrene treatment of rats on the microsomal binding and hydroxylation of nortriptyline and desmethyl-imipramine: evidence for qualitative changes in cytochrome P-450-ligand interaction following phenobarbital pretreatmen
Topics: Animals; Benzopyrenes; Binding Sites; Chromatography, Gas; Cytochrome P-450 Enzyme System; Desipramine; Hexobarbital; Ligands; Male; Microsomes, Liver; Mixed Function Oxygenases; Nortriptyline; Phenobarbital; Protein Binding; Rats; Receptors, Drug; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1972 |
Imipramine and chlorpromazine in hepatic microsomal systems.
Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Microsomes, Liver; Phenobarbital; Proadifen; Proteins; Spectrophotometry, Ultraviolet | 1974 |
Effect of psychotherapeutic drugs on hyperemotionality of rats in which the olfactory bulb was removed.
Topics: Amitriptyline; Animals; Benperidol; Chlordiazepoxide; Chlorpromazine; Chlorprothixene; Desipramine; Emotions; Imipramine; Limbic System; Male; Meprobamate; Phenobarbital; Rats; Reserpine; Tranquilizing Agents | 1967 |
A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats.
Topics: Animals; Antipyrine; Desipramine; Enzyme Induction; In Vitro Techniques; Liver; Male; Nortriptyline; Perfusion; Phenobarbital; Phenylbutazone; Rats; Tremorine | 1970 |
Pharmacology-toxicology.
Topics: Antidepressive Agents; Blood Pressure; Brain; Contraceptives, Oral; Cytochromes; Desipramine; Diazepam; Endoplasmic Reticulum; Histamine; Lidocaine; Liver; Methylphenidate; Methyltyrosines; National Institutes of Health (U.S.); Norepinephrine; Norethindrone; Nortriptyline; Oxyphenbutazone; Pharmaceutical Preparations; Phenobarbital; Placenta; Progesterone; Smoking; United States | 1970 |
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chlorides; Chromatography, Paper; Dealkylation; Desipramine; Ethylamines; Imipramine; Liver; Magnesium; Male; Metabolism; Methylation; Oxidation-Reduction; Oxides; Phenobarbital; Proadifen; Rats; Valerates | 1970 |
Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. I. Experiments in vivo and with isolated perfused livers.
Topics: Alcohols; Animals; Benzyl Compounds; Bile; Bile Acids and Salts; Biliary Fistula; Chromatography, Thin Layer; Desipramine; Glucuronates; Imines; Imipramine; Injections, Intravenous; Intestine, Small; Kinetics; Laparotomy; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Time Factors | 1970 |
[Kinetics, intracellular localization and inducibility of monoamine oxidase].
Topics: Animals; Benzopyrenes; Desipramine; Enzyme Induction; Imipramine; Kinetics; Liver; Microsomes; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenobarbital; Polarography; Rabbits; Rats | 1967 |
Inhibition of the metabolism of H3-melatonin by phenothiazines.
Topics: Amphetamine; Animals; Antimetabolites; Body Temperature; Brain; Chlorpromazine; Depression, Chemical; Desipramine; Female; Imipramine; Liver; Melatonin; Phenobarbital; Phenothiazines; Promazine; Promethazine; Rats; Tritium | 1968 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine; Diazepam; Dibenzazepines; Drug Synergism; Ethanol; Humans; Imipramine; Methylphenidate; Mice; Nortriptyline; Phenelzine; Phenobarbital; Reflex; Substance-Related Disorders; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1968 |
Enhancement of noradrenaline pressor responses in testosterone-treated cats.
Topics: Animals; Blood Pressure; Cats; Desipramine; Drug Synergism; Ethers; Female; Male; Norepinephrine; Phenobarbital; Testosterone | 1967 |
Increased binding of desmethylimipramine in plasma of phenobarbital-treated rats.
Topics: Animals; Blood Proteins; Desipramine; Erythrocytes; Female; Male; Orosomucoid; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains | 1982 |
The effect of moderate hemodilution with Fluosol on cytochrome P4502D6 activity in the rat.
Topics: Animals; Blood Substitutes; Cytochrome P-450 Enzyme System; Desipramine; Enzyme Induction; Fluorocarbons; Hemodilution; Isoenzymes; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1994 |
Depletion of brain norepinephrine: differential influence on anxiolyic treatment effects.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzylamines; Biogenic Monoamines; Brain Chemistry; Conflict, Psychological; Desipramine; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Monoamine Oxidase Inhibitors; Norepinephrine; Phenelzine; Phenobarbital; Rats; Rats, Sprague-Dawley; Sympathomimetics | 1999 |
Metabolite-intermediate complexation and inhibition of microsomal CYP3A in rat liver by diltiazem.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Desipramine; Dexamethasone; Diltiazem; Enzyme Inhibitors; Immunoblotting; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Wistar; Spectrophotometry; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone | 2000 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liquid; Desipramine; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Imipramine; Lamotrigine; Nortriptyline; Phenobarbital; Phenylethylmalonamide; Polyurethanes; Primidone; Reproducibility of Results; Sensitivity and Specificity; Silanes; Time Factors; Triazines | 2006 |