phenobarbital has been researched along with dactinomycin in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (86.67) | 18.7374 |
| 1990's | 6 (6.67) | 18.2507 |
| 2000's | 3 (3.33) | 29.6817 |
| 2010's | 3 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Badawy, AA; Evans, M | 1 |
| Berger, H; Jarosch, E; Madreiter, H; Richter, H | 1 |
| Raw, I; Rockwell, P | 1 |
| Bhat, KS; Padmanaban, G | 1 |
| Alvares, AP; Kappas, A | 1 |
| Bridges, JW; McPherson, FJ; Parke, DV | 1 |
| Breuer, H; Haueter, G; Rao, GS; Rao, ML | 1 |
| DeLuca, P; DeLuca, PP; Rusmin, S; Welton, S | 1 |
| Hazan, N; McCauley, R | 1 |
| Jorgensen, AJ; Majumdar, AP | 1 |
| Anderson, J; Nievel, JG | 1 |
| Anderson, J; Nievel, JG; Robinson, N | 1 |
| Anderson, J; Nievel, JG; Skrbic, TR | 1 |
| Degkwitz, E; Dubberstein, M; Walsch, S; Winter, J | 2 |
| Padmanaban, G; Rajamanickam, C; Rao, MR | 1 |
| Hirata, M; Tonda, K | 1 |
| Kuroiwa, Y; Numazawa, S; Oguro, T; Yoshida, T | 1 |
| del Carmen Vila, M; San Martin de Viale, LC | 1 |
| Bonkovsky, HL; Healey, JF; Lincoln, BC | 1 |
| Meneguz, A; Michalek, H | 1 |
| Gielen, JE; Nebert, DW | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G | 1 |
| Scharf, R; Ullrich, V | 2 |
| Kappas, A; Poland, A | 1 |
| Matsumura, S; Omura, T | 1 |
| Dalton, C; Hope, HR; Hope, WC; Sheppard, H | 1 |
| Higgins, JA | 1 |
| Gelboin, HV | 2 |
| Burgison, RM; Dietz, AJ | 1 |
| Ernzerhoff, C; Holtz, P; Palm, D | 1 |
| Alvares, AP; Bickers, DR; Kappas, A | 1 |
| Lange, G | 2 |
| Bousquet, WF; Driever, CW; Miya, TS | 1 |
| Deb, C; Hanker, JS; Morizono, Y; Seligman, AM; Zenker, N | 1 |
| Cooper, SD; Feuer, G | 1 |
| Ericsson, JL; Ernster, L; Orrenius, S | 1 |
| Brodeur, J; Gascon, AL | 1 |
| Burkhalter, A; Howland, RD | 1 |
| Belpaire, FM; Lee, NH | 1 |
| Hollatz, R; Tempel, K | 1 |
| Chiari, R; Tragl, KH | 1 |
| Quan, L; Riley, S; Rowe, J; Sadoff, L | 1 |
| Yokoyama, T | 1 |
| Roberts, RJ | 1 |
| Hunter, J; Maxwell, JD; Stewart, DA; Williams, R | 1 |
| Accatino, L; Contreras, A; Gumucio, JJ; Macho, AM | 1 |
| Malathi, K; Padmanaban, G; Rao, MR | 1 |
| Seifert, J | 1 |
| Acheampong-Mensah, D; Feuer, G | 1 |
| Nichol, AW | 1 |
| Altman, K; Gordon, GG; Southren, AL; Vittek, J; Wilker, S | 1 |
| Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Cloutier, G; Gascon, AL | 1 |
| Prabhu, VG | 1 |
| Dehn, F; LeValley, SE; Lombrozo, L; Mitoma, C | 1 |
| Arcos, JC; Argus, MF; Venkatesan, N | 1 |
| Conway, MW; Kaul, PN | 1 |
| Fouts, JR; Stock, BH | 1 |
| Weisburger, EK; Weisburger, JH; Yamamoto, RS | 1 |
| Mueller, RA; Shideman, FE | 1 |
| Golberg, L; Nievel, JG | 1 |
| Alvares, AP; Kuntzman, R; Levin, W; Schilling, G | 1 |
| Gelboin, HV; Nebert, DW | 1 |
| Plaa, GL; Roberts, RJ | 1 |
| Ericsson, JL; Orrenius, S | 1 |
| Fouts, JR; Wilson, JT | 1 |
| Blake, DA; Cascorbi, HF; Krantz, JC; Rozman, RS | 1 |
| Gielen, JE; Goujon, FM; Van Cantfort, J | 1 |
| Ishidate, K; Nakazawa, Y; Tsuruoka, M | 1 |
| Kleeberg, U; Klinger, W | 1 |
| Desiderio, MA; Perin, A; Sessa, A | 1 |
| Bisschop, A; Derks, HJ; van Rooijen, LA; van Wijk, R | 1 |
| Gancho, VIu; Ivanova, LI; Smirnov, AV | 1 |
| Kojo, A; Negishi, M; Pasanen, M; Pelkonen, O; Raunio, H; Salonpää, P | 1 |
| Monostory, K; Vereczkey, L | 1 |
| Kottari, S; Pelkonen, O; Raunio, H; Salonpää, P | 1 |
| Akiyoshi, T; Arakaki, M; Kase, A | 1 |
| Carrère, N; Daujat, M; Fabre, JM; Gerbal-Chaloin, S; Maurel, P; Pascussi, JM; Pichard-Garcia, L; Waechter, F | 1 |
| Edwards, RJ; Guengerich, FP; Hollenberg, PF; Kim, H; Novak, RF; Putt, DA; Wolf, CR; Zangar, RC | 1 |
| DUBOIS, KP; KINOSHITA, F | 2 |
| BOUSQUET, WF; DRIEVER, CW | 1 |
| Gupta, S; Rathaur, S | 1 |
2 review(s) available for phenobarbital and dactinomycin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Studies on the mechanism of microsomal hydroxylase induction and its role in carcinogen action.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Carbon Isotopes; Carcinogens; Cells, Cultured; Cricetinae; Cytidine; Dactinomycin; Electrophoresis; Enzyme Induction; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Neoplasms; Phenobarbital; Protein Biosynthesis; Rats; RNA; RNA Nucleotidyltransferases; Tritium; Uridine | 1972 |
88 other study(ies) available for phenobarbital and dactinomycin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.
Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Humans; Hydrocortisone; Liver; Male; Morphine; NADP; Nicotinyl Alcohol; Phenobarbital; Premedication; Pyridines; Rats; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1975 |
[Experiments on the biosynthesis of UDP-Glucuronyltransferase and UDP-Glucosyltransferase under the influence of eucalyptol (author's transl)].
Topics: Animals; Bilirubin; Cycloheximide; Dactinomycin; Enzyme Activation; Enzyme Induction; Eucalyptus; Glucosyltransferases; Hymecromone; Mice; Pentosyltransferases; Phenobarbital; Plant Extracts; Plants, Medicinal | 1977 |
Effect of a single dose of inducers and inhibitors on the rate of synthesis of cytochromes and reductases in liver organelles.
Topics: Aflatoxins; Animals; Chloramphenicol; Cycloheximide; Cytochrome Reductases; Cytochromes; Dactinomycin; Female; Liver; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Rabbits | 1979 |
Cytochrome P-450 synthesis in vivo and in a cell-free system from rat liver.
Topics: Animals; Cell-Free System; Cytochrome P-450 Enzyme System; Dactinomycin; Immunologic Techniques; Liver; Male; Phenobarbital; Rats; Triazoles | 1978 |
The inducing properties of polychlorinated biphenyls on hepatic monooxygenases.
Topics: Animals; Aroclors; Cytochromes; Dactinomycin; Enzyme Induction; Female; In Vitro Techniques; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Pregnancy; Rats | 1977 |
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes.
Topics: Acetone; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Benzopyrenes; Catechol Oxidase; Cricetinae; Cytochromes; Dactinomycin; Dioxoles; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nikethamide; Phenobarbital; Rats; Safrole | 1976 |
Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes.
Topics: Animals; Bilirubin; Castration; Cycloheximide; Dactinomycin; Detergents; Estradiol; Estrone; Female; Glucuronates; Hexosyltransferases; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Testosterone | 1977 |
Effect of inline filtration on the potency of drugs administered intravenously.
Topics: Cephalothin; Dactinomycin; Dexamethasone; Digoxin; Drug Stability; Filtration; Infusions, Parenteral; Isoproterenol; Phenobarbital; Phenytoin | 1977 |
Effect of phenobarbitone on the nucleocytoplasmic transport of ribonucleic acid in vitro.
Topics: Animals; Biological Transport; Cell Nucleus; Cycloheximide; Cytosol; Dactinomycin; Liver; Male; Nucleoproteins; Phenobarbital; Rats; RNA, Ribosomal | 1976 |
Influence of tryptophan on the level of hepatic microsomal cytochrome P-450 in well-fed normal, adrenalectomized, and phenobarbital-treated rats.
Topics: Adrenalectomy; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Dactinomycin; Hydrocortisone; Male; Microsomes, Liver; Phenobarbital; Proteins; Rats; Tryptophan | 1976 |
Competition between the induction of hepatic protein synthesis by drugs and inhibition by actinomycin D indicating a mechanism for decreased acute toxicity in vio apparently independent of stimulated drug metabolism.
Topics: Animals; Dactinomycin; Female; Hepatomegaly; Liver; Phenobarbital; Protein Biosynthesis; Rats; Transcription, Genetic | 1976 |
Changes in nucleotide metabolism of the liver and fate of [14C]orotate among various pyrimidines at the outset and during induction of drug-metabolizing enzymes and hepatomegaly.
Topics: Animals; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; DNA Replication; Enzyme Induction; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Protein Biosynthesis; Rats; Ribonucleotides; Transcription, Genetic; Uracil | 1976 |
Studies on the relationship between induction of drug-metabolizing enzymes, liver enlargement and ascorbic acid excretion in rodents.
Topics: Animals; Ascorbic Acid; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucuronates; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Proadifen; Rats; Transcription, Genetic; Uracil; Uracil Nucleotides | 1976 |
Ascorbic acid and cytochromes.
Topics: Adrenal Glands; Aminolevulinic Acid; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Cycloheximide; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Guinea Pigs; Iron; Kidney Cortex; Liver; Phenobarbital; Spleen | 1975 |
On the sequence of reactions leading to cytochrome P-450 synthesis-effect of drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Apoproteins; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Endoplasmic Reticulum; Glycine; Heme; Iron; Liver; Male; Microsomes, Liver; Phenobarbital; Rats | 1975 |
Effect of L-methionine on 2-carboxybenzaldehyde reductase induction by phenobarbital in primary cultures of rat hepatocytes.
Topics: Alcohol Oxidoreductases; Animals; Cells, Cultured; Cycloheximide; Cystathionine; Dactinomycin; Enzyme Induction; Glutathione; In Vitro Techniques; Male; Methionine; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Induction of ornithine decarboxylase and S-adenosylmethionine decarboxylase by sulfobromophthalein in rats.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Kinetics; Liver; Male; Methylcholanthrene; Ornithine Decarboxylase; Phenobarbital; Polyamines; Rats; Rats, Inbred Strains; Sulfobromophthalein | 1989 |
delta-Aminolaevulinate synthase: mechanism of its response to malathion.
Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Cycloheximide; Dactinomycin; Enzyme Induction; Hemin; Liver; Malathion; Phenobarbital | 1988 |
Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals.
Topics: Animals; Cations, Divalent; Cells, Cultured; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Glutethimide; Heme; Heme Oxygenase (Decyclizing); Liver; Mephenytoin; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Porphyrins | 1988 |
Induction of hepatic microsomal mixed function oxidase system by ethylenethiourea in mice.
Topics: Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Dactinomycin; Enzyme Induction; Ethylenethiourea; Imidazoles; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1986 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. II. Effects of actinomycin D and cycloheximide on induction processes by phenobarbital or polycyclic hydrocarbons.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carbon Isotopes; Cell Nucleolus; Cells, Cultured; Cycloheximide; Dactinomycin; Drug Antagonism; Enzyme Induction; Fetus; Half-Life; Kinetics; Liver; Metabolism; Mixed Function Oxygenases; Phenobarbital; Polycyclic Compounds; Proteins; Rats; RNA, Ribosomal; Tritium; Uridine | 1971 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
In vitro induction of drug monooxygenase activity by phenobarbital in the isolated mouse jejunum.
Topics: Animals; Carbon Isotopes; Coumarins; Dactinomycin; Dealkylation; Enzyme Induction; In Vitro Techniques; Intestinal Mucosa; Jejunum; Leucine; Male; Mice; Oxygenases; Phenobarbital; Protein Binding; Protein Biosynthesis; Puromycin | 1973 |
Chlorcyclizine N-demethylase activity in chick embryo hepatic cell culture.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Acetylation; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Dactinomycin; Endoplasmic Reticulum; Enzyme Induction; Estradiol; Etiocholanolone; Gestational Age; Ketosteroids; Liver; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Piperazines; Proteins; Testosterone; Tritium | 1973 |
Stability of messenger RNA's for microsomal NADPH-cytochrome c reductase and cytochrome b 5 in the livers of normal and phenobarbital-treated rats.
Topics: Amino Acids; Animals; Cytochromes; Dactinomycin; Half-Life; Lysine; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; Oxidoreductases; Phenobarbital; Rats; RNA, Messenger; Tritium | 1973 |
Relationship of serum triglyceride lowering to changes in hepatic composition induced by different classes of drugs.
Topics: Animals; Cholesterol; Clofibrate; Dactinomycin; DNA; Dose-Response Relationship, Drug; Glycolates; Hepatomegaly; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Nafenopin; Oxidoreductases, N-Demethylating; Phenobarbital; Phenyl Ethers; Phenytoin; Phospholipids; Piperazines; Piperidines; Propionates; Proteins; Rats; RNA; Spectrophotometry, Ultraviolet; Triglycerides | 1974 |
Studies on the biogenesis of smooth endoplasmic reticulum membranes in hepatocytes of phenobarbital-treated rats. II. The site of phospholipid synthesis in the initial phase of membrane proliferation.
Topics: Acyltransferases; Animals; Carbon Radioisotopes; Cell Division; Cytochrome Reductases; Dactinomycin; Dihydrolipoamide Dehydrogenase; Endoplasmic Reticulum; Glycerol; Liver; Male; Membranes; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Proteins; Puromycin; Rats; Time Factors | 1974 |
In vitro induction by phenobarbital of drug monooxygenase activity in mouse isolated small intestine.
Topics: Animals; Carbon Radioisotopes; Coumarins; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dactinomycin; Dealkylation; Enzyme Induction; Fluorometry; Hydrogen-Ion Concentration; Intestinal Mucosa; Jejunum; Leucine; Male; Mice; Microsomes; NADP; Oxygenases; Perfusion; Phenobarbital; Puromycin; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Carcinogenesis and gene action. Franz Bielschowsky Memorial Lecture.
Topics: Animals; Azo Compounds; Carcinogens; Dactinomycin; DNA; Enzyme Induction; Genes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Molecular Biology; Neoplasms; Neoplasms, Experimental; Phenobarbital; Phenotype; Puromycin; Rats; RNA; RNA Nucleotidyltransferases | 1968 |
The biotransformation of 8-ethylthio-6-thiotheophylline sodium in vivo.
Topics: Amines; Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Dactinomycin; Depression, Chemical; Hypnotics and Sedatives; Male; Methylcholanthrene; Oils; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical; Theophylline; Time Factors | 1968 |
[On the activation of dopa decarboxylase and other cytoplasmic liver enzymes by inducers of microsomal enzymes].
Topics: Animals; Carboxy-Lyases; Dactinomycin; Dopa Decarboxylase; Enzyme Induction; Ethionine; Hexachlorocyclohexane; L-Lactate Dehydrogenase; Liver; Microsomes; Monoamine Oxidase; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Tolbutamide | 1967 |
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Enzyme Induction; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry; Stimulation, Chemical | 1973 |
[Completion of the induction of microsomal enzymes in the rabbit liver].
Topics: Aniline Compounds; Animals; Chloromercuribenzoates; Cytochromes; Dactinomycin; Depression, Chemical; Enzyme Induction; Ethionine; Ethylmaleimide; Liver; Microsomes; Mixed Function Oxygenases; Phenanthrolines; Phenobarbital; Quinolines; Rabbits | 1967 |
Stress stimulation of drug metabolism in the rat.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Corticosterone; Dactinomycin; Hexobarbital; Hypophysectomy; In Vitro Techniques; Meprobamate; Pentobarbital; Phenobarbital; Pituitary Gland; Pituitary-Adrenal System; Rats; Stress, Physiological | 1966 |
Carcinogens 3,4-benzpyrene and 3-methylcholanthrene: induction of mitochondrial oxidative enzymes.
Topics: Animals; Benzopyrenes; Dactinomycin; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Enzyme Induction; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hydroxybutyrate Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Methylcholanthrene; Mitochondria, Liver; Phenobarbital; Rats; Stimulation, Chemical; Succinate Dehydrogenase; Tetrazolium Salts; Triiodothyronine | 1968 |
Relation between drug-metabolizing activity and phospholipids in hepatic microsomes. I. Effects of phenobarbital, carbon tetrachloride, and actinomycin D.
Topics: Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucose-6-Phosphatase; Lysophosphatidylcholines; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phosphatidylethanolamines; Phospholipids; Proteins; Rats; Stimulation, Chemical | 1972 |
Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study.
Topics: Aminopyrine; Animals; Carbon Monoxide; Codeine; Dactinomycin; Endoplasmic Reticulum; In Vitro Techniques; Liver; Microscopy, Electron; Microsomes; NADP; Nitrosamines; Oxidoreductases; Phenobarbital; Pigments, Biological; Puromycin; Rats; Thyroidectomy; Triiodothyronine | 1965 |
[Differential induction of microsomal N- and p-hydroxylation of aniline and N-ethylamiline in rabbits].
Topics: Anesthetics, Local; Aniline Compounds; Animals; Chloramphenicol; Dactinomycin; Enzyme Induction; Ethionine; Female; Hydroxylamines; Liver; Male; Microsomes; Mixed Function Oxygenases; NADP; Phenobarbital; Phenols; Rabbits | 1967 |
Influence of microsomal enzyme inducers on the reactivity of the isolated guinea pig seminal vesicle to angiotensin and tyramine.
Topics: Angiotensin II; Animals; Aspirin; Dactinomycin; DDT; Drug Antagonism; Enzyme Induction; Glutethimide; Guinea Pigs; Male; Meprobamate; Methylcholanthrene; Microsomes; Phenobarbital; Piperazines; Proadifen; Protein Biosynthesis; Seminal Vesicles; Sulfanilamides; Tyramine | 1969 |
Some effects of 3-methylcholanthrene on uridine diphosphate glucuronyltransferase in the rat and guinea pig.
Topics: Animals; Dactinomycin; Enzyme Induction; Ethionine; Glucuronates; Glucuronosyltransferase; Guinea Pigs; Hexosyltransferases; Hydrocarbons; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Magnesium; Male; Methylcholanthrene; Microsomes, Liver; Nikethamide; Nucleoside Diphosphate Sugars; Phenobarbital; Phenols; Piperazines; Protein Biosynthesis; Rats; Time Factors; Uracil Nucleotides | 1971 |
Study of the increased glyceryl trinitrate metabolism after pretreatment with phenobarbital in rat liver.
Topics: Animals; Body Weight; Dactinomycin; Ethionine; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Reductase; In Vitro Techniques; Liver; Male; NADP; Nitrates; Nitroglycerin; Organ Size; Phenobarbital; Proteins; Rats; Spectrophotometry, Ultraviolet | 1972 |
[Induction effects in the mouse under the influence of polyanions].
Topics: Aniline Compounds; Animals; Carbon Radioisotopes; Dactinomycin; DNA; Enzyme Induction; Female; Folic Acid; In Vitro Techniques; Kidney; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Orotic Acid; Phenobarbital; Phenylalanine; Polysaccharides; Protein Biosynthesis; RNA; Sulfuric Acids | 1974 |
Phenobarbital and the protein synthesis of liver ribosomes.
Topics: Animals; Binding Sites; Dactinomycin; Endoplasmic Reticulum; Female; Liver; Phenobarbital; Poly U; Polyribosomes; Rats; Ribosomal Proteins; Ribosomes; RNA, Ribosomal | 1974 |
New endocrine observations in a male patient with choriocarcinoma.
Topics: Adult; Brain Neoplasms; Cerebrospinal Fluid Proteins; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dexamethasone; Diagnostic Errors; Estradiol; Humans; Hydrocortisone; Lung Neoplasms; Luteinizing Hormone; Male; Medroxyprogesterone; Methotrexate; Neoplasm Metastasis; Phenobarbital; Testosterone; Vincristine | 1974 |
Experimental and cytopathological studies on the nucleic acid synthesis of murine hepatocytes.
Topics: Acetamides; Aflatoxins; Animals; Cell Nucleolus; Cell Nucleus; Chromatin; Cytoplasm; Dactinomycin; DNA; Hepatectomy; Heterochromatin; Liver; Male; Mice; Mycotoxins; Naphthoquinones; p-Dimethylaminoazobenzene; Penicillium; Phenobarbital; Rats; RNA; Sulfur | 1972 |
Microsomal metabolism of the hepatotoxin -naphthylisothiocyanate (ANIT) following phenobarbital, chlorpromazine or actinomycin D treatment.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Cell Fractionation; Chlorpromazine; Dactinomycin; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rats; Thiocyanates | 1973 |
Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea-pigs: relationship during enzyme induction and following inhibition of protein synthesis.
Topics: Adipates; Animals; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Guinea Pigs; Liver; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Time Factors | 1973 |
Effect of phenobarbital on the ethynyl estradiol-induced cholestasis in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cycloheximide; Dactinomycin; Ethinyl Estradiol; Female; Injections, Intraperitoneal; Injections, Intravenous; Liver; Phenobarbital; Rats; Stimulation, Chemical; Time Factors | 1973 |
A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver.
Topics: 5-Aminolevulinate Synthetase; Adrenalectomy; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Castration; Citrates; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Female; Heme; Hydrocortisone; Iron Radioisotopes; Liver; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Protein Binding; Rats | 1973 |
Tryptophan pyrrolase in rat liver after phenobarbital administration.
Topics: Animals; Ascorbic Acid; Dactinomycin; Enzyme Activation; Enzyme Induction; Heme; Hydrocortisone; Liver; Male; Phenobarbital; Proteins; Rats; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
Influence of L-ascorbate on the contents of cytochromes P-450 and b5 in several organs of guinea pigs.
Topics: Adrenal Glands; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Ferritins; Gluconates; Guinea Pigs; Iron; Kidney; Levulinic Acids; Liver; Microsomes; Microsomes, Liver; Mitochondria, Liver; Organ Specificity; Phenobarbital; Spleen; Time Factors | 1973 |
Relation between the hepatic action of drugs and the synthesis of subcellular structures.
Topics: Aminopyrine N-Demethylase; Analysis of Variance; Animals; Choline; Dactinomycin; Deficiency Diseases; Diet; Drug Interactions; In Vitro Techniques; Liver; Male; Methionine; Methylation; Methyltransferases; Microsomes, Liver; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Protein Biosynthesis; Rats; S-Adenosylmethionine; Subcellular Fractions | 1974 |
The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors.
Topics: Acetanilides; Animals; Ascorbic Acid; Azides; Bile Pigments; Carbon Monoxide; Chickens; Chloramphenicol; Culture Techniques; Cyanides; Cycloheximide; Dactinomycin; Erythrocytes; Ethylmaleimide; Female; Heme; Hydrogen Peroxide; Macrophages; Metabolism; Microscopy, Phase-Contrast; Mitomycins; Phagocytosis; Phenobarbital; Proadifen; Quinacrine; Spectrophotometry; Spectrum Analysis; Stimulation, Chemical; Triazoles | 1970 |
Induction of hepatic testosterone A-ring reductase by medroxyprogesterone acetate.
Topics: 17-Ketosteroids; Adrenal Glands; Androstanes; Animals; Carbon Isotopes; Castration; Chromatography, Paper; Chromatography, Thin Layer; Dactinomycin; Enzyme Induction; Fasting; Hydrocortisone; Liver; Male; Medroxyprogesterone; Microsomes, Liver; Oxidoreductases; Phenobarbital; Progesterone; Rats; Spectrophotometry; Testosterone; Time Factors | 1972 |
Effect of dactinomycin on phenobarbital-induced ultrastructural changes in rat hepatocytes.
Topics: Animals; Cell Division; Dactinomycin; Endoplasmic Reticulum; Enzyme Induction; Female; Golgi Apparatus; Liver; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1971 |
Modification of catecholamine content of male accessory sexual tissues of guinea pig after pretreatment with microsomal enzyme inducers.
Topics: Adrenal Glands; Animals; Brain; Castration; Catecholamines; Dactinomycin; DDT; Epinephrine; Guinea Pigs; Male; Methylcholanthrene; Norepinephrine; Pargyline; Phenobarbital; Proteins; Seminal Vesicles; Testis; Vas Deferens | 1971 |
Effect of chronic treatment with therapeutically useful antibiotics on the response of certain pharmacologic agents in the rat.
Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Chlordan; Chlortetracycline; Dactinomycin; Drug Antagonism; Drug Tolerance; Enzyme Induction; Enzymes; Hexobarbital; Male; Oxytetracycline; Penicillins; Phenobarbital; Rats; Sleep; Streptomycin | 1970 |
Nature of the effect of caffeine on the drug-metabolizing enzymes.
Topics: 17-Hydroxycorticosteroids; Acetanilides; Amino Acids; Aminopyrine; Aniline Compounds; Animals; Caffeine; Cytochromes; Dactinomycin; Drug Antagonism; Enzyme Induction; Female; Humans; Male; Methylation; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnanes; Pyridones; Rats; Stimulation, Chemical; Time Factors; Zoxazolamine | 1969 |
Mechanism of 3-methylcholanthrene-induced inhibition of dimethylnitrosamine demethylase in rat liver.
Topics: Animals; Dactinomycin; Female; Kinetics; Liver; Male; Methylcholanthrene; Methyltestosterone; Microsomes, Liver; Nitrosamines; Oxidoreductases; Phenobarbital; Puromycin; Rats; Sex Factors; Time Factors | 1970 |
Induction and inhibition of in vivo glucuronidation of apomorphine in mice.
Topics: Animals; Apomorphine; Dactinomycin; Enzyme Induction; Estradiol; Female; Glucuronates; Male; Mice; Pentobarbital; Phenobarbital; Proadifen; Sleep; Testosterone; Time Factors | 1971 |
The influence of in vivo administration of dimethyl sulfoxide on the in vitro metabolism of some monocyclic aromatic chemicals by hepatic microsomal preparations.
Topics: Acetanilides; Aniline Compounds; Animals; Anisoles; Biotransformation; Cycloheximide; Cytochromes; Dactinomycin; Dimethyl Sulfoxide; Female; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Phenobarbital; Rabbits; Rats; Stimulation, Chemical | 1971 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Phenothiazines; Proadifen; Puromycin; Urethane | 1971 |
The prolongation of reserpine-induced cardiac norepinephrine depletion by metabolic inhibitors.
Topics: Adrenal Medulla; Amides; Animals; Dactinomycin; Depression, Chemical; Drug Synergism; Heart; In Vitro Techniques; Liver; Male; Myocardium; Norepinephrine; Perfusion; Phenobarbital; Proadifen; Rats; Reserpine; Sulfhydryl Compounds; Tritium | 1968 |
Effect of coumarin and other compounds on ribosomal protein synthesis in the rat liver.
Topics: Amino Acids; Animals; Coumarins; Cresols; Dactinomycin; Depression, Chemical; Female; Liver; Male; Oils; Phenobarbital; Polynucleotides; Protein Biosynthesis; Rats; Ribosomes; RNA, Messenger; Stimulation, Chemical; Uracil Nucleotides; Zea mays | 1968 |
Alteration of the microsomal hemoprotein by 3-methylcholanthrene: effects of ethionine and actinomycin D.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochromes; Dactinomycin; Enzyme Induction; Ethionine; Liver; Male; Methionine; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rats; Solubility; Spectrophotometry | 1968 |
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction.
Topics: Aging; Animals; Benz(a)Anthracenes; Brain; Carbon Monoxide; Chick Embryo; Cricetinae; Culture Techniques; Cycloheximide; Cytochromes; Dactinomycin; Enzyme Induction; Fetus; Guinea Pigs; Intestine, Small; Kinetics; Liver; Lung; Mice; Microsomes; Mixed Function Oxygenases; Phenobarbital; Puromycin; Rats; RNA, Messenger; Spectrum Analysis; Time Factors | 1968 |
Potentiation and inhibition of alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis.
Topics: Animals; Chlorpromazine; Cholestasis; Dactinomycin; Ethionine; Hyperbilirubinemia; In Vitro Techniques; Mice; Microsomes; Phenobarbital; Proadifen; Thiocyanates | 1965 |
Enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranes.
Topics: Animals; Cell Membrane; Dactinomycin; Endoplasmic Reticulum; In Vitro Techniques; Liver; Microscopy, Electron; Microsomes; Oxidoreductases; Phenobarbital; Phospholipids; Phosphorus Isotopes; Puromycin; Rats | 1966 |
The effect of actinomycin D on post-phenobarbital activity of hepatic microsomal drug-metabolizing enzymes in the rat.
Topics: Aminopyrine; Animals; Dactinomycin; Hexobarbital; In Vitro Techniques; Liver; Microsomes; Phenobarbital; Rats | 1966 |
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Dactinomycin; Dogs; Ethers; Ethyl Ethers; Ethylamines; Female; Male; Methylcholanthrene; Mice; Nitrous Oxide; Phenobarbital; Proadifen | 1967 |
Comparison of aryl hydrocarbon hydroxylase and epoxide hydratase. Induction in primary fetal rat liver cell culture.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cells, Cultured; Cycloheximide; Dactinomycin; DNA; Enzyme Induction; Epoxide Hydrolases; Kinetics; Liver; Nicotiana; Phenobarbital; Plants, Toxic; Polychlorinated Dibenzodioxins; Protein Biosynthesis; Rats; RNA; Smoke; Stilbenes | 1980 |
Induction of choline kinase by polycyclic aromatic hydrocarbon carcinogens in rat liver.
Topics: Animals; Carcinogens; Choline Kinase; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phosphotransferases; Polycyclic Compounds; Rats | 1980 |
Glucose-6-phosphatase activities in the developing rat liver and kidney and after phenobarbital, 3-methylcholanthrene, and actinomycin D pretreatment.
Topics: Aging; Animals; Animals, Laboratory; Animals, Newborn; Dactinomycin; Glucose-6-Phosphatase; Kidney; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Induction of diamine oxidase activity in rat kidney during compensatory hypertrophy.
Topics: Acetaldehyde; Amine Oxidase (Copper-Containing); Animals; Cycloheximide; Dactinomycin; Enzyme Induction; Hypertrophy; Kidney; Male; Nephrectomy; Phenobarbital; Polyamines; Putrescine; Pyrroles; Rats; Rats, Inbred Strains | 1982 |
Induction of rat hepatic ornithine decarboxylase by the tumor promotors 12-O-tetradecanoylphorbol-13-acetate and phenobarbital in vivo; effect of retinyl-acetate.
Topics: Animals; Carboxy-Lyases; Cycloheximide; Dactinomycin; Diterpenes; Enzyme Induction; Female; Kinetics; Liver; Ornithine Decarboxylase; Phenobarbital; Phorbols; Rats; Retinyl Esters; Tetradecanoylphorbol Acetate; Vitamin A | 1981 |
[An analysis of the mechanism of the resistance to barbiturate action by using exogenous RNA].
Topics: Animals; Barbiturates; Dactinomycin; Drug Resistance; Drug Tolerance; Hexobarbital; Methods; Microsomes, Liver; Organ Specificity; Phenobarbital; Protein Biosynthesis; Proteins; Rats; RNA; Sleep; Time Factors | 1993 |
Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aryl Hydrocarbon Hydroxylases; Bucladesine; Cells, Cultured; Colforsin; Cycloheximide; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dactinomycin; Enzyme Induction; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Phenobarbital; RNA, Messenger | 1994 |
The effect of phenobarbital and dexamethasone coadministration on the activity of rat liver P450 system.
Topics: Aminopyrine N-Demethylase; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Dexamethasone; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethylmorphine-N-Demethylase; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Time Factors | 1994 |
Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytes.
Topics: Animals; Arginine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Griseofulvin; Heme; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Nitrobenzoates; Phenobarbital; RNA, Messenger | 1997 |
[Studies on the biological effects of disulufiram--effect of an active metabolite of disulfiram on the activity of delta-aminolevulinic acid synthetase].
Topics: 5-Aminolevulinate Synthetase; Animals; Dactinomycin; Ditiocarb; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Enzyme Inhibitors; Glycyrrhiza; Ketones; Liver; Male; Nucleic Acid Synthesis Inhibitors; Paeonia; Phenobarbital; Rats; Rats, Wistar | 1998 |
Induction of CYP2C genes in human hepatocytes in primary culture.
Topics: Adult; Aged; Cell Line; Cells, Cultured; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cytochrome P-450 Enzyme System; Dactinomycin; Dexamethasone; Enzyme Induction; Female; Hepatocytes; Humans; Hydroxylation; Immunoblotting; Isoenzymes; Kinetics; Liver; Male; Middle Aged; Nuclease Protection Assays; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Receptors, Virus; Rifampin; RNA, Messenger; Tyrosine Transaminase | 2001 |
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Clofibrate; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dactinomycin; Deoxyadenosines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Alignment; Transcription, Genetic | 2001 |
THE EFFECTS OF IONIZING RADIATIONS ON THE BIOCHEMISTRY OF MAMMALIAN TISSUES. II. INFLUENCE OF VARIOUS FACTORS ON RADIATION-INDUCED INHIBITION OF THE DEVELOPMENT OF DETOXIFICATION ENZYMES. QUART PROGR REP 50.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Brain; Cholinesterases; Clinical Enzyme Tests; Dactinomycin; Diethylstilbestrol; Liver; Metabolism; Methyltestosterone; Nikethamide; Organophosphate Poisoning; Pharmacology; Phenobarbital; Phosphorus; Poisons; Progesterone; Puromycin; Radiation Injuries; Radiation Injuries, Experimental; Radiation, Ionizing; Rats; Research; Testosterone; Toxicology | 1964 |
THE EFFECTS OF IONIZING RADIATIONS ON THE BIOCHEMISTRY OF MAMMALIAN TISSUES. I. THE INFLUENCE OF X-IRRADIATION AND CHEMICAL AGENTS ON DETOXIFICATION MECHANISMS. QUART PROGR REP 49.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Benzopyrenes; Dactinomycin; Liver; Methylcholanthrene; Nikethamide; Organophosphate Poisoning; Pharmacology; Phenobarbital; Phosphorus; Poisons; Puromycin; Radiation Injuries; Radiation Injuries, Experimental; Radiation, Ionizing; Rats; Research; Toxicology | 1963 |
STRESS-DRUG INTERACTIONS: EVIDENCE FOR RAPID ENZYME INDUCTION.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Blood; Corticosterone; Dactinomycin; Drug Interactions; Enzyme Induction; Hexobarbital; Hypophysectomy; Liver; Meprobamate; Metabolism; Morphine; Pentobarbital; Pharmacology; Phenobarbital; Physiology; Rats; Research; Stress, Physiological | 1965 |
Filarial glutathione S-transferase: its induction by xenobiotics and potential as drug target.
Topics: Animals; Butylated Hydroxyanisole; Dactinomycin; Diethylcarbamazine; Dinitrochlorobenzene; Electrophoresis, Polyacrylamide Gel; Ellagic Acid; Enzyme Activation; Ethacrynic Acid; Female; Glutathione Transferase; Phenobarbital; Setaria Nematode; Substrate Specificity | 2005 |