phenobarbital has been researched along with cycloheximide in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 67 (79.76) | 18.7374 |
| 1990's | 15 (17.86) | 18.2507 |
| 2000's | 2 (2.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Akamatsu, N; Miura, Y; Nakajima, H; Ono, M | 1 |
| Badawy, AA; Evans, M | 1 |
| Berger, H; Jarosch, E; Madreiter, H; Richter, H | 1 |
| Raw, I; Rockwell, P | 1 |
| Castro, JA; Diaz Gomez, MI | 1 |
| Accatino, L; Simon, FR; Sutherland, E | 1 |
| Abakumova, OIu; Kutsenko, NG; Lerman, MI; Podobed, OV | 1 |
| Botham, KM; Boyd, GS | 1 |
| Jennett, RB; Sorrell, MF; Tuma, DJ | 1 |
| de Matteis, F; Gibbs, AH; Järvisalo, J | 1 |
| Fawade, MM; Pawar, SS | 1 |
| Breuer, H; Haueter, G; Rao, GS; Rao, ML | 1 |
| Morton, AG; Tavill, AS | 1 |
| Hazan, N; McCauley, R | 1 |
| Degkwitz, E; Dubberstein, M; Walsch, S; Winter, J | 1 |
| Kamath, SA; Rubin, E | 1 |
| Padmanaban, G; Rajamanickam, C; Rao, MR | 1 |
| Deitrich, RA; Erwin, G; Troxell, PA | 1 |
| Cooksley, WG; Tavill, AS | 1 |
| Alcedo, JA; Bement, WJ; Hamilton, JW; Sinclair, JF; Sinclair, PR; Wetterhahn, KE | 1 |
| Sakamoto, S; Shichi, H | 1 |
| Hirata, M; Tonda, K | 1 |
| Ades, IZ; Ryan, G | 1 |
| Dickmann, Z; Terranova, PF | 1 |
| Burger, HJ; Guzelian, PS; Schuetz, EG; Schuetz, JD | 1 |
| Padmanaban, G; Rangarajan, PN | 1 |
| Kuroiwa, Y; Numazawa, S; Oguro, T; Yoshida, T | 1 |
| Cánepa, ET; Grinstein, M; Llambías, EB | 1 |
| Antoine, B; Boutin, JA; Fournel, S; Siest, G | 1 |
| del Carmen Vila, M; San Martin de Viale, LC | 1 |
| Bonkovsky, HL; Healey, JF; Lincoln, BC | 1 |
| Higaki, J; Hirata, M; Tonda, K | 1 |
| Chan, P; Goldberg, DM; Parkes, JG | 1 |
| Gielen, JE; Nebert, DW | 1 |
| Negishi, M; Omura, T | 1 |
| Jondorf, WR; Miller, HH | 1 |
| Kyogoku, Y; Yu, NT | 1 |
| Boyd, GS; Brown, MJ | 1 |
| Bock, KW; Fröhling, W; Remmer, H; Rexer, B | 1 |
| Japundzić, I; Japundzić, M; Mimic-Oka, J | 1 |
| Kikuchi, G; Kim, HJ; Oashi, A; Tomita, Y; Watarai, K | 1 |
| Glaumann, H; Lindeborg, T | 1 |
| Accatino, L; Contreras, A; Gumucio, JJ; Macho, AM | 1 |
| Heischkeil, R | 1 |
| Jonen, HG; Kahl, GF; Kahl, R | 1 |
| Nichol, AW | 1 |
| Kühn, HA; Richter, E | 1 |
| Malathi, K; Padmanaban, G; Rao, MR | 1 |
| Burchell, B; Dutton, GJ; Nemeth, AM | 1 |
| Imai, Y; Siekevitz, P | 1 |
| Russell, DH | 1 |
| Long, RF | 1 |
| Bond, EJ; De Matteis, F | 1 |
| Glaumann, H | 1 |
| Hasegawa, E; Smith, C; Tephly, TR | 1 |
| Henderson, PT | 1 |
| Couri, D; McCauley, R | 1 |
| Fouts, JR; Stock, BH | 1 |
| Weisburger, EK; Weisburger, JH; Yamamoto, RS | 1 |
| Israels, LG; Levitt, M; Schacter, BA; Zipursky, A | 1 |
| Gelboin, HV; Nebert, DW | 1 |
| Edwards, AM | 1 |
| Gielen, JE; Goujon, FM; Van Cantfort, J | 1 |
| Accatino, L; Davis, RA; Gonzalez, M; Simon, FR; Sutherland, E | 1 |
| Ishidate, K; Nakazawa, Y; Tsuruoka, M | 1 |
| Omura, T; Sadano, H | 1 |
| Desiderio, MA; Perin, A; Sessa, A | 1 |
| Fischer, E; Gregus, Z; Varga, F | 1 |
| Bridges, JW; Fry, JR; Wiebkin, P | 1 |
| Muschick, H; Rifkind, AB; Troeger, M | 1 |
| Bisschop, A; Derks, HJ; van Rooijen, LA; van Wijk, R | 1 |
| Correia, MA; Farrell, GC | 1 |
| Chipman, JK; Coleman, R; Guppy, MJ; Sharma, R; Wilton, JC | 1 |
| Kojo, A; Negishi, M; Pasanen, M; Pelkonen, O; Raunio, H; Salonpää, P | 1 |
| Dogra, SC; Hahn, CN; May, BK | 1 |
| Monostory, K; Vereczkey, L | 1 |
| Bergelson, S; Daniel, V; Pinkus, R | 1 |
| Li, Y; Plaa, GL; Yousef, IM | 1 |
| Nirodi, CS; Padmanaban, G; Prabhu, L; Ram, N; Sultana, S | 1 |
| Horie, Y; Karbowski, M; Kurono, C; Nishizawa, Y; Soji, T; Wakabayashi, T | 1 |
| Novak, RF; Zangar, RC | 1 |
| Edwards, RJ; Guengerich, FP; Hollenberg, PF; Kim, H; Novak, RF; Putt, DA; Wolf, CR; Zangar, RC | 1 |
| Gupta, C; Yaffe, SJ | 1 |
1 review(s) available for phenobarbital and cycloheximide
| Article | Year |
|---|---|
[Pathophysiology and clinical aspects of intrahepatic cholestasis].
Topics: Alkaline Phosphatase; Animals; Arsphenamine; Bile Acids and Salts; Bilirubin; Chlorpromazine; Cholangitis; Cholestasis; Cholesterol; Copper; Cycloheximide; Hepatitis A; Humans; Liver; Liver Cirrhosis, Biliary; Liver Diseases; Methyltestosterone; Phenobarbital; Phospholipids; Rats; Thiocyanates | 1970 |
83 other study(ies) available for phenobarbital and cycloheximide
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Increase in acetyl CoA synthetase activity after phenobarbital treatment.
Topics: Acetate-CoA Ligase; Acetylesterase; Acetylglucosamine; Animals; Coenzyme A Ligases; Cycloheximide; Glucosamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Liver; Male; Phenobarbital; Phosphotransferases; Proteins; Rats; Stimulation, Chemical | 1975 |
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.
Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Humans; Hydrocortisone; Liver; Male; Morphine; NADP; Nicotinyl Alcohol; Phenobarbital; Premedication; Pyridines; Rats; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1975 |
[Experiments on the biosynthesis of UDP-Glucuronyltransferase and UDP-Glucosyltransferase under the influence of eucalyptol (author's transl)].
Topics: Animals; Bilirubin; Cycloheximide; Dactinomycin; Enzyme Activation; Enzyme Induction; Eucalyptus; Glucosyltransferases; Hymecromone; Mice; Pentosyltransferases; Phenobarbital; Plant Extracts; Plants, Medicinal | 1977 |
Effect of a single dose of inducers and inhibitors on the rate of synthesis of cytochromes and reductases in liver organelles.
Topics: Aflatoxins; Animals; Chloramphenicol; Cycloheximide; Cytochrome Reductases; Cytochromes; Dactinomycin; Female; Liver; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Rabbits | 1979 |
Further studies on the mechanism of the carbon tetrachloride induced polysome breakdown.
Topics: Age Factors; Amitrole; Animals; Carbon Tetrachloride; Cycloheximide; In Vitro Techniques; Liver; Male; Malonates; Methylcholanthrene; Mice; Mice, Inbred A; Niacinamide; Phenobarbital; Polyribosomes; Proadifen; Pyrazoles; Rats | 1976 |
Stimulation of hepatic sodium and potassium-activated adenosine triphosphatase activity by phenobarbital. Its possible role in regulation of bile flow.
Topics: Adenosine Triphosphatases; Animals; Bile; Bile Acids and Salts; Cycloheximide; Glucose-6-Phosphatase; Kinetics; Liver; Male; Nucleotidases; Organ Specificity; Phenobarbital; Potassium; Rats; Sodium; Subcellular Fractions; Thyroid Gland; Thyroxine | 1977 |
[Accelerated microsomal DNA synthesis under the influence of xenobiotics and chemical carcinogens].
Topics: Animals; Benzopyrenes; Caffeine; Cell Nucleus; Cycloheximide; DNA; DNA, Mitochondrial; DNA, Neoplasm; Hydroxyurea; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Puromycin; Stimulation, Chemical | 1979 |
Cholesterol 7 alpha-hydroxylase in isolated rat liver cells.
Topics: Animals; Biological Transport; Cholesterol 7-alpha-Hydroxylase; Cholestyramine Resin; Cholic Acids; Cycloheximide; Cytochrome P-450 Enzyme System; Female; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Phenobarbital; Rats; Steroid Hydroxylases; Taurocholic Acid | 1979 |
Impairment of glycoprotein secretion by phenobarbital in rat liver slices.
Topics: Animals; Cycloheximide; Glucosamine; Glycoproteins; In Vitro Techniques; Kinetics; Liver; Male; Phenobarbital; Rats | 1978 |
Accelerated conversion of heme to bile pigments caused in the liver by carbon disulfide and other sulfur-containing chemicals.
Topics: Animals; Bile Pigments; Carbon Disulfide; Cycloheximide; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Sulfur | 1978 |
Alterations in the toxicity of thiodemeton due to the pretreatment of inducers, substrates and inhibitors of mixed function oxidase system.
Topics: Acetanilides; Aminopyrine; Animals; Cobalt; Cycloheximide; Disulfoton; Enzyme Induction; Ethylmorphine; Female; Insecticides; Male; Methylcholanthrene; Mixed Function Oxygenases; Nickel; Oxidoreductases; Phenobarbital; Rats | 1978 |
Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes.
Topics: Animals; Bilirubin; Castration; Cycloheximide; Dactinomycin; Detergents; Estradiol; Estrone; Female; Glucuronates; Hexosyltransferases; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Testosterone | 1977 |
The role of iron in the regulation of hepatic transferrin synthesis.
Topics: Animals; Cycloheximide; In Vitro Techniques; Iron; Iron Deficiencies; Liver; Male; Phenobarbital; Protein Binding; Rats; Serum Albumin; Transferrin | 1977 |
Effect of phenobarbitone on the nucleocytoplasmic transport of ribonucleic acid in vitro.
Topics: Animals; Biological Transport; Cell Nucleus; Cycloheximide; Cytosol; Dactinomycin; Liver; Male; Nucleoproteins; Phenobarbital; Rats; RNA, Ribosomal | 1976 |
Ascorbic acid and cytochromes.
Topics: Adrenal Glands; Aminolevulinic Acid; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Cycloheximide; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Guinea Pigs; Iron; Kidney Cortex; Liver; Phenobarbital; Spleen | 1975 |
The use of cation-bound microsomes for studies of protein synthesis.
Topics: Animals; Calcium; Carbon Tetrachloride; Cations, Divalent; Centrifugation, Density Gradient; Cycloheximide; Leucine; Liver; Magnesium; Microsomes, Liver; Phenobarbital; Polyribosomes; Protein Biosynthesis; Rats; Ribosomes; Sucrose | 1975 |
On the sequence of reactions leading to cytochrome P-450 synthesis-effect of drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Apoproteins; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Endoplasmic Reticulum; Glycine; Heme; Iron; Liver; Male; Microsomes, Liver; Phenobarbital; Rats | 1975 |
Characteristics of the induction of aldehyde dehydrogenase in rat liver.
Topics: Aldehyde Oxidoreductases; Allylisopropylacetamide; Animals; Cycloheximide; Cytosol; Enzyme Induction; Heme; Liver; Phenobarbital; Rats; Species Specificity; Time Factors | 1975 |
Heterogeneity of hepatic vitamin B12 in the rat after parenteral cyanocobalamin.
Topics: Animals; Bile; Cycloheximide; Injections, Intramuscular; Kidney; Kinetics; Liver; Male; Phenobarbital; Rats; Subcellular Fractions; Vitamin B 12 | 1975 |
Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes.
Topics: Animals; Base Sequence; Chick Embryo; Cycloheximide; Gene Expression; Liver; Molecular Sequence Data; Nitrophenols; Oligodeoxyribonucleotides; Phenobarbital; Protein Synthesis Inhibitors; RNA, Messenger; Structure-Activity Relationship; Transcription, Genetic | 1992 |
Distribution and induction of alkoxyresorufin O-dealkylases and gamma-glutamyl transpeptidase in porcine ciliary epithelium.
Topics: Animals; Cells, Cultured; Ciliary Body; Cycloheximide; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epithelium; gamma-Glutamyltransferase; Methylcholanthrene; Microsomes; Oxidoreductases; Phenobarbital; Swine | 1990 |
Effect of L-methionine on 2-carboxybenzaldehyde reductase induction by phenobarbital in primary cultures of rat hepatocytes.
Topics: Alcohol Oxidoreductases; Animals; Cells, Cultured; Cycloheximide; Cystathionine; Dactinomycin; Enzyme Induction; Glutathione; In Vitro Techniques; Male; Methionine; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
On the mechanism of induction of chick embryo hepatic delta-aminolaevulinate synthase by translational blockers.
Topics: 5-Aminolevulinate Synthetase; Amanitins; Animals; Chick Embryo; Cycloheximide; Enzyme Induction; Liver; Phenobarbital; Protein Biosynthesis; Ricin | 1991 |
Ovulation blockade through synergism of cycloheximide with assorted anesthetics.
Topics: Anesthetics; Animals; Cricetinae; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Ether; Female; Ketamine; Ovulation; Pentobarbital; Phenobarbital | 1990 |
Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes.
Topics: Animals; Blotting, Northern; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver; Male; Phenobarbital; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; RNA, Messenger; Sex Factors | 1990 |
Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor.
Topics: Animals; Base Sequence; Cell Nucleus; Cloning, Molecular; Cycloheximide; Cytochrome P-450 Enzyme System; Exons; Gene Expression Regulation; Genes; Heme; Liver; Molecular Sequence Data; Phenobarbital; Rats; Reference Values; Transcription Factors; Transcription, Genetic | 1989 |
Induction of ornithine decarboxylase and S-adenosylmethionine decarboxylase by sulfobromophthalein in rats.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Kinetics; Liver; Male; Methylcholanthrene; Ornithine Decarboxylase; Phenobarbital; Polyamines; Rats; Rats, Inbred Strains; Sulfobromophthalein | 1989 |
Effect of glucose on induction of delta-aminolevulinic acid synthase, ferrochelatase and cytochrome P-450 hemoproteins in isolated rat hepatocytes by phenobarbital and lead.
Topics: 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Epinephrine; Ferrochelatase; Glucose; Hemeproteins; Insulin; Lead; Liver; Lyases; Male; Phenobarbital; Rats; Subcellular Fractions; Theophylline | 1985 |
Heterogeneity of hepatic microsomal UDP-glucuronosyltransferases activities: use and comparison of differential inductions in some mammalian species.
Topics: Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Guinea Pigs; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Gunn; Rats, Inbred Strains | 1987 |
delta-Aminolaevulinate synthase: mechanism of its response to malathion.
Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Cycloheximide; Dactinomycin; Enzyme Induction; Hemin; Liver; Malathion; Phenobarbital | 1988 |
Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals.
Topics: Animals; Cations, Divalent; Cells, Cultured; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Glutethimide; Heme; Heme Oxygenase (Decyclizing); Liver; Mephenytoin; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Porphyrins | 1988 |
Induction of 2-carboxybenzaldehyde reductase by phenobarbital in primary culture of rat hepatocytes.
Topics: Alcohol Oxidoreductases; Animals; Cycloheximide; Cytosol; Enzyme Induction; Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Rats | 1986 |
Secretion of triglyceride lipase from rat hepatocytes in culture: modulation by insulin and phenobarbital.
Topics: Animals; Cell Division; Cells, Cultured; Cycloheximide; Insulin; Kinetics; Lipase; Liver; Monensin; Phenobarbital; Rats | 1986 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. II. Effects of actinomycin D and cycloheximide on induction processes by phenobarbital or polycyclic hydrocarbons.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carbon Isotopes; Cell Nucleolus; Cells, Cultured; Cycloheximide; Dactinomycin; Drug Antagonism; Enzyme Induction; Fetus; Half-Life; Kinetics; Liver; Metabolism; Mixed Function Oxygenases; Phenobarbital; Polycyclic Compounds; Proteins; Rats; RNA, Ribosomal; Tritium; Uridine | 1971 |
The early stage of labeling of microsomal membrane proteins in rat liver by radioactive amino acids.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Membrane; Cycloheximide; Cytochrome c Group; Cytochrome Reductases; Guanidines; Leucine; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Puromycin; Rats | 1972 |
Glutarimide antibiotics and drug metabolism in the rat.
Topics: Aminopyrine; Animals; Anti-Bacterial Agents; Azo Compounds; Cyclohexanes; Cycloheximide; Dealkylation; Female; In Vitro Techniques; Microsomes, Liver; Naphthalenes; Oxidation-Reduction; Phenobarbital; Piperidones; Protein Biosynthesis; Rats; Sulfonamides; Sulfonic Acids | 1973 |
Specific H-bonding of glutarimides and hydantoins to derivatives of RNA bases in chloroform solution.
Topics: Bemegride; Chemical Phenomena; Chemistry; Chloroform; Cycloheximide; Ethosuximide; Glutethimide; Hydantoins; Pemoline; Phenobarbital; Phenytoin; Piperidines; Piperidones; Primidone; RNA; Spectrophotometry, Infrared; Thalidomide | 1973 |
The specificity of the rat-liver cholesterol 7alpha-hydroxylase.
Topics: Alcohol Oxidoreductases; Aminopyrine N-Demethylase; Androstenols; Animals; Cholesterol; Cholestyramine Resin; Cycloheximide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Pregnenolone; Protein Binding; Rats; Time Factors | 1974 |
Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase.
Topics: Ammonium Sulfate; Animals; Bilirubin; Chemical Precipitation; Chloramphenicol; Cycloheximide; Deoxycholic Acid; Enzyme Activation; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Naphthols; Nitrophenols; Phenobarbital; Rats; Structure-Activity Relationship; Surface-Active Agents; Trypsin | 1973 |
Increased hepatic phosphoprotein phosphatase activity induced by phenobarbital and its supression by cycloheximide and SKF 525-A.
Topics: Animals; Cycloheximide; Enzyme Induction; Kinetics; Liver; Male; Phenobarbital; Phosphoproteins; Phosphoric Monoester Hydrolases; Proadifen; Rats; Time Factors | 1972 |
Comparative study on induction of hepatic delta-aminolevulinate synthetase by different drugs.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Bucladesine; Cells, Cultured; Chick Embryo; Cycloheximide; Cytosol; Dicarboxylic Acids; Enzyme Induction; Heme; Liver; Mitochondria, Liver; Phenobarbital; Pyridines; Rats; Species Specificity; Time Factors | 1973 |
Effect of a catatoxic steroid pregnenolone-16alpha-carbonitrile, on rat liver microsomal subfractions.
Topics: Adenosine Triphosphatases; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Cycloheximide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dose-Response Relationship, Drug; Female; Glucose-6-Phosphatase; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nucleosides; Phenobarbital; Phospholipids; Phosphoric Monoester Hydrolases; Pregnenolone Carbonitrile; Proteins; Rats | 1974 |
Effect of phenobarbital on the ethynyl estradiol-induced cholestasis in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cycloheximide; Dactinomycin; Ethinyl Estradiol; Female; Injections, Intraperitoneal; Injections, Intravenous; Liver; Phenobarbital; Rats; Stimulation, Chemical; Time Factors | 1973 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene | 1973 |
Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome P-450.
Topics: Alkanes; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrogen-Ion Concentration; In Vitro Techniques; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Solvents; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors | 1974 |
The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors.
Topics: Acetanilides; Animals; Ascorbic Acid; Azides; Bile Pigments; Carbon Monoxide; Chickens; Chloramphenicol; Culture Techniques; Cyanides; Cycloheximide; Dactinomycin; Erythrocytes; Ethylmaleimide; Female; Heme; Hydrogen Peroxide; Macrophages; Metabolism; Microscopy, Phase-Contrast; Mitomycins; Phagocytosis; Phenobarbital; Proadifen; Quinacrine; Spectrophotometry; Spectrum Analysis; Stimulation, Chemical; Triazoles | 1970 |
The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver.
Topics: 5-Aminolevulinate Synthetase; Amides; Animals; Bilirubin; Catalase; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucose; Half-Life; Heme; Liver; Microsomes, Liver; Phenobarbital; Porphyrins; Proadifen; Rats | 1972 |
Development of phenobarbital-sensitive control mechanisms for uridine diphosphate glucuronyltransferase activity in chick embryo liver.
Topics: Age Factors; Animals; Carbon Isotopes; Cell Fractionation; Chick Embryo; Culture Media; Cycloheximide; Hexosyltransferases; Kinetics; Leucine; Liver; Methods; Organ Culture Techniques; Phenobarbital; Protein Biosynthesis; RNA; Tritium; Uridine | 1972 |
A comparison of some properties of microsomal cytochrome P-450 from normal, methylcholanthrene-, and phenobarbital-treated rats.
Topics: 1-Propanol; Amines; Animals; Chemical Phenomena; Chemistry; Chlorides; Cycloheximide; Cytochromes; Fasting; Fatty Alcohols; Heme; Hydrogen-Ion Concentration; Kinetics; Male; Mathematics; Mercury; Methylcholanthrene; Microsomes, Liver; Nitriles; Oxidation-Reduction; Phenobarbital; Potassium; Protein Biosynthesis; Rats; Spectrophotometry; Sulfites; Thiocyanates; Triazoles | 1971 |
Drug stimulation of putrescine and spermidine syntheses. Relationships to enhancement of ribonucleic acid synthesis.
Topics: Animals; Benzopyrenes; Carboxy-Lyases; Clofibrate; Cycloheximide; Heparin; Liver; Male; Methylcholanthrene; Ornithine; Phenobarbital; Polyamines; Putrescine; Rats; RNA; S-Adenosylmethionine; Spermidine; Stimulation, Chemical; Tritium; Uridine | 1971 |
Induction of drug-metabolizing enzymes and cytochrome P-450.
Topics: Cycloheximide; Cytochromes; Endoplasmic Reticulum; Enzyme Induction; Liver; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Phenothiazines; Puromycin | 1969 |
Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes.
Topics: Adjuvants, Anesthesia; Aniline Compounds; Animals; Anisoles; Blood Proteins; Body Weight; Carbon Disulfide; Carbon Isotopes; Cycloheximide; Cytochromes; DNA; Fasting; Heme; Injections, Intraperitoneal; Leucine; Lipids; Liver; Liver Glycogen; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Organ Size; Phenobarbital; Proadifen; Protein Biosynthesis; Proteins; Rats; RNA; Spectrophotometry; Sucrose; Time Factors | 1969 |
Studies on the synthesis and transport of albumin in microsomal subfractions from rat liver.
Topics: Adsorption; Albumins; Animals; Biological Transport; Carbon Isotopes; Cycloheximide; Electrophoresis, Disc; Endoplasmic Reticulum; Femoral Vein; Injections, Intraperitoneal; Injections, Intravenous; Leucine; Liver; Male; Membranes; Microsomes, Liver; Phenobarbital; Phospholipids; Portal Vein; Rats; Ribosomes; Vibration | 1970 |
Induction of hepatic mitochondrial ferrochelatase by phenobarbital.
Topics: Acyltransferases; Animals; Cobalt; Cycloheximide; Enzyme Induction; Heme; Kinetics; Levulinic Acids; Liver; Lyases; Male; Metabolism; Mitochondria, Liver; Nickel; Oxygen; Phenobarbital; Porphyrins; Rats; Succinates | 1970 |
Phenobarbital induction of UDP-glucuronyltransferase in isolated rat hepatocytes.
Topics: Animals; Culture Techniques; Cycloheximide; Enzyme Induction; Liver; Male; Nitrophenols; Phenobarbital; Protein Biosynthesis; Rats; Spectrophotometry; Transferases | 1971 |
Early effects of phenobarbital on cytoplasmic RNA in rat liver.
Topics: Animals; Bile Acids and Salts; Carbon Isotopes; Centrifugation, Density Gradient; Cycloheximide; Cytoplasm; Endoplasmic Reticulum; Kinetics; Leucine; Liver; Male; Membranes; Microsomes, Liver; Orotic Acid; Peptide Biosynthesis; Phenobarbital; Rats; Ribosomes; RNA; RNA, Ribosomal; Time Factors; Ultracentrifugation | 1971 |
The influence of in vivo administration of dimethyl sulfoxide on the in vitro metabolism of some monocyclic aromatic chemicals by hepatic microsomal preparations.
Topics: Acetanilides; Aniline Compounds; Animals; Anisoles; Biotransformation; Cycloheximide; Cytochromes; Dactinomycin; Dimethyl Sulfoxide; Female; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Phenobarbital; Rabbits; Rats; Stimulation, Chemical | 1971 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Phenothiazines; Proadifen; Puromycin; Urethane | 1971 |
The nonerythropoietic component of early bilirubin.
Topics: Amides; Amino Acids; Animals; Bile Ducts; Biliary Fistula; Bilirubin; Carbon Isotopes; Catalase; Cycloheximide; Cytochromes; Erythropoiesis; Glycine; Heme; Infusions, Parenteral; Kidney; Lead Poisoning; Levulinic Acids; Male; Nephrectomy; Phenobarbital; Porphyrins; Protein Biosynthesis; Rats; Triazoles | 1968 |
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction.
Topics: Aging; Animals; Benz(a)Anthracenes; Brain; Carbon Monoxide; Chick Embryo; Cricetinae; Culture Techniques; Cycloheximide; Cytochromes; Dactinomycin; Enzyme Induction; Fetus; Guinea Pigs; Intestine, Small; Kinetics; Liver; Lung; Mice; Microsomes; Mixed Function Oxygenases; Phenobarbital; Puromycin; Rats; RNA, Messenger; Spectrum Analysis; Time Factors | 1968 |
Relationship between inductions of monooxygenase activity and gamma-glutamyltranspeptidase in rat hepatocyte primary cultures.
Topics: Animals; Bucladesine; Cells, Cultured; Cycloheximide; Dexamethasone; gamma-Glutamyltransferase; Kinetics; Liver; Male; Mixed Function Oxygenases; Niacinamide; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1984 |
Comparison of aryl hydrocarbon hydroxylase and epoxide hydratase. Induction in primary fetal rat liver cell culture.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cells, Cultured; Cycloheximide; Dactinomycin; DNA; Enzyme Induction; Epoxide Hydrolases; Kinetics; Liver; Nicotiana; Phenobarbital; Plants, Toxic; Polychlorinated Dibenzodioxins; Protein Biosynthesis; Rats; RNA; Smoke; Stilbenes | 1980 |
Reversal of ethinyl estradiol-induced bile secretory failure with Triton WR-1339.
Topics: Animals; Bile; Bile Acids and Salts; Cycloheximide; Ethinyl Estradiol; Liver; Male; Membrane Lipids; Membranes; Organ Size; Phenobarbital; Polyethylene Glycols; Rats; Sodium-Potassium-Exchanging ATPase | 1980 |
Induction of choline kinase by polycyclic aromatic hydrocarbon carcinogens in rat liver.
Topics: Animals; Carcinogens; Choline Kinase; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phosphotransferases; Polycyclic Compounds; Rats | 1980 |
Reversible transfer of heme between different molecular species of microsome-bound cytochrome P-450 in rat liver.
Topics: Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Heme; Isoenzymes; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1983 |
Induction of diamine oxidase activity in rat kidney during compensatory hypertrophy.
Topics: Acetaldehyde; Amine Oxidase (Copper-Containing); Animals; Cycloheximide; Dactinomycin; Enzyme Induction; Hypertrophy; Kidney; Male; Nephrectomy; Phenobarbital; Polyamines; Putrescine; Pyrroles; Rats; Rats, Inbred Strains | 1982 |
Effects of cobalt chloride and cycloheximide on the hepatic microsomal enzyme system and biliary excretion rate in control and phenobarbital-pretreated rats.
Topics: Animals; Bile; Bromcresol Green; Cobalt; Cycloheximide; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Sleep | 1983 |
7-Ethoxycoumarin O-deethylase induction by phenobarbitone and 1,2-benzanthracene in primary maintenance cultures of adult rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benz(a)Anthracenes; Cell Nucleus; Cells, Cultured; Cycloheximide; Enzyme Induction; Liver; Male; Oxygenases; Phenobarbital; Rats; Time Factors | 1980 |
Kinetic evidence for heterogeneous responsiveness of mixed function oxidase isozymes to inhibition and induction by allylisopropylacetamide in chick embryo liver.
Topics: 7-Alkoxycoumarin O-Dealkylase; Acetamides; Allylisopropylacetamide; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxygenases; Phenobarbital | 1982 |
Induction of rat hepatic ornithine decarboxylase by the tumor promotors 12-O-tetradecanoylphorbol-13-acetate and phenobarbital in vivo; effect of retinyl-acetate.
Topics: Animals; Carboxy-Lyases; Cycloheximide; Dactinomycin; Diterpenes; Enzyme Induction; Female; Kinetics; Liver; Ornithine Decarboxylase; Phenobarbital; Phorbols; Rats; Retinyl Esters; Tetradecanoylphorbol Acetate; Vitamin A | 1981 |
Structural and functional reconstitution of hepatic cytochrome P-450 in vivo. Reversal of allylisopropylacetamide-mediated destruction of the hemoprotein by exogenous heme.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ethylmorphine-N-Demethylase; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Modulation of phenobarbitone-induced loss of gap junctional intercellular communication in hepatocyte couplets.
Topics: Animals; Biotransformation; Cell Communication; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme System; Drug Interactions; Gap Junctions; Glutathione; Liver; Male; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Staining and Labeling; Time Factors | 1994 |
Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aryl Hydrocarbon Hydroxylases; Bucladesine; Cells, Cultured; Colforsin; Cycloheximide; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dactinomycin; Enzyme Induction; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Phenobarbital; RNA, Messenger | 1994 |
Superinduction by cycloheximide of cytochrome P4502H1 and 5-aminolevulinate synthase gene transcription in chick embryo liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Nucleus; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; DNA Probes; Kinetics; Liver; Phenobarbital; RNA; RNA, Messenger; Transcription, Genetic | 1993 |
The effect of phenobarbital and dexamethasone coadministration on the activity of rat liver P450 system.
Topics: Aminopyrine N-Demethylase; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Dexamethasone; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethylmorphine-N-Demethylase; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Time Factors | 1994 |
Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.
Topics: Arsenates; Arsenites; Base Sequence; Binding Sites; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Chlorides; Cycloheximide; Gene Expression Regulation; Genes, fos; Genes, jun; Genes, Regulator; Glutathione Transferase; Humans; Hydrocarbons; Hydrogen Peroxide; Molecular Sequence Data; Phenobarbital; Phorbol Esters; Proto-Oncogene Proteins c-jun; Quinone Reductases; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Zinc Compounds | 1994 |
1-Naphthyl isocyanate and 1-naphthylamine as metabolites of 1-naphthylisothiocyanate.
Topics: 1-Naphthylamine; 1-Naphthylisothiocyanate; Animals; Bile; Biotransformation; Cycloheximide; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Involvement of synthesis and phosphorylation of nuclear protein factors that bind to the positive cis-acting element in the transcriptional activation of the CYP2B1/B2 gene by phenobarbitone in vivo.
Topics: 2-Aminopurine; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Binding Sites; Cycloheximide; Cytochrome P-450 Enzyme System; DNA; Enzyme Inhibitors; Ethers, Cyclic; Molecular Sequence Data; Nuclear Proteins; Okadaic Acid; Phenobarbital; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats; RNA, Messenger; Steroid Hydroxylases; Transcription, Genetic | 1996 |
Induction of megamitochondria by some chemicals inducing oxidative stress in primary cultured rat hepatocytes.
Topics: Animals; Bromobenzenes; Cell Survival; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme System; Erythromycin; Free Radicals; Hydrazines; Hydrogen Peroxide; Lipid Peroxides; Liver; Male; Malondialdehyde; Microscopy, Confocal; Microscopy, Electron; Mitochondria, Liver; Oxidative Stress; Phenobarbital; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 1997 |
Posttranslational elevation of cytochrome P450 3A levels and activity by dimethyl sulfoxide.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Kinetics; Liver; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Polyribosomes; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid Hydroxylases; Substrate Specificity; Testosterone; Time Factors; Transcription, Genetic | 1998 |
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Clofibrate; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dactinomycin; Deoxyadenosines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Alignment; Transcription, Genetic | 2001 |
Phenobarbital-induced alterations in the sexual differentiation of the female rat: reversal by hydroxyurea and cycloheximide.
Topics: Animals; Cycloheximide; Estrous Cycle; Female; Fertility; Hydroxyurea; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sex Differentiation | 1982 |