phenobarbital and cobalt

phenobarbital has been researched along with cobalt in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	61 (82.43)	18.7374
1990's	9 (12.16)	18.2507
2000's	3 (4.05)	29.6817
2010's	1 (1.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Uehleke, H; Werner, T	1
Shigematsu, H; Yamano, S; Yoshimura, H	1
Castro, JA; Diaz Gomez, MI; Godoy, HM	1
Timbrell, JA	1
Campbell, RL; Hettrick, JM; Nigro, ND; Suppnick, JD	1
Anders, MW; Lindstrom, TD	1
Allemand, H; Benhamou, JP; DeGott, C; Descatoire, V; Feldmann, G; Pessayre, D	1
Drew, R; Priestly, BG	1
Beatty, PW; Neal, RA; Vaughn, WK	1
Chivrac, D; Dumont, M; Erlinger, S	1
Fawade, MM; Pawar, SS	1
Abernethy, DR; Azarnoff, DL	1
Bell, P; Gutmann, HR	1
Mitchell, JR; Timbrell, JA	1
David, JC	1
Correia, MA; Meyer, UA	1
Couture, J; Dahlström-King, L; Plaa, GL	1
Hahnemann, B; Honkakoski, P; Juvonen, R; Lang, MA; Mäenpää, J; Pasanen, M; Pelkonen, O; Raunio, H; Salonpää, P	1
Imai, S; Onozuka, M	1
Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP	1
Alexander, J; Mikalsen, A; Ryberg, D	1
Fujino, S; Hoshi, K; Senda, N	1
Brown, PI; Rankin, GO; Richmond, CD; Shih, HC; Teets, VJ; Yang, DJ	1
Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G	1
Lindup, WE; Orton, TC; Rosenbaum, SE	1
Dwarki, VI; Francis, VN; Padmanaban, G	1
Chengelis, CP; Neal, RA	1
Padmanaban, G; Ravishankar, H	3
Bien, E; Witt, M	1
Kuwahara, S; Mannering, GJ	1
Kling, L; Legrum, W; Netter, KJ	1
Das, M; Mukhtar, H; Seth, PK; Srivastava, SP	1
Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ	3
Bellward, GD; Morgan, RG; Szombathy, VH	1
Fouts, JR; Peters, MA	1
Dow, RC; Forfar, JC; McQueen, JK	1
van Duijn, H; Visser, SL	1
De Matteis, F	1
Bellward, GD; Black, NB; Dayton, PG; O'Brien, L; Perel, JM	1
Gautieri, RF; Mitala, JJ	1
Sladek, NE	1
Hasegawa, E; Smith, C; Tephly, TR	1
Oguri, K; Watanabe, K; Yamamoto, I; Yoshimura, H	1
Narimatsu, S; Watanabe, K; Yamamoto, I; Yoshimura, H	1
Bolt, HM; Filser, JG; Schmiedel, G	1
de Valkeneer, FD; Gilbert, PJ; Mercier, M; Poncelet, F; Rollmann, B; Rondelet, J	1
Avren'eva, LI; Kravchenko, LV; Tutel'ian, VA	1
Babany, G; Cobert, B; Funck-Brentano, C; Larrey, D; Pessayre, D; Tinel, M	1
Watanabe, K; Yoshizawa, I	1
Bien, E	1
Buchet, JP; de Hoffmann, E; Lauwerys, R; Scailteur, V	1
Mitchell, JR; Nelson, SD; Snodgrass, WR; Timbrell, JA	1
Clark, JD; Hatch, RC; Jain, AV; Weiss, R	2
Fischer, E; Gregus, Z; Varga, F	1
Kaliman, PA; Padalko, VI	1
Ibrahim, NG; Levere, RD; Nelson, JC	1
Aune, T; Dybing, E; Nelson, SD	1
Dramiński, W; Klimczak, J; Tarkowski, S; Wisniewska-Knypl, JM; Wróblewska, K	1
Legrum, W; Netter, KJ; Stuehmeier, G	1
Belvedere, G; Cantoni, L; Cantoni, R; Salmona, M; Vignazia, E	1
Anestis, DK; Beers, KW; Brown, PI; Nicoll, DW; Rankin, GO	1
Brossier, P; Jaouen, G; Salmain, M; Vessières, A	1
Amatsu, T; Asaka, Y; Kanamura, S; Watanabe, J	1
Nirodi, CS; Padmanaban, G; Prabhu, L; Ram, N; Sultana, S	1
Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T	1
Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E	1
Ali, M; Dayal, M; Dhawan, A; Dwivedi, UN; Parmar, D; Seth, PK	1
De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E	1
Numazawa, S; Shindo, S; Shizu, R; Yoshida, T	1

Reviews

1 review(s) available for phenobarbital and cobalt

Article	Year
The role of metabolism in the hepatotoxicity of isoniazid and iproniazid. Drug metabolism reviews, 1979, Volume: 10, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cobalt; Humans; Hydrazines; Iproniazid; Isoniazid; Phenobarbital	1979

Other Studies

73 other study(ies) available for phenobarbital and cobalt

Article	Year
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo. Archives of toxicology, 1975, Dec-18, Volume: 34, Issue:4 Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity	1975
NADH-dependent O-deethylation of p-nitrophenetole with rabbit liver microsomes. Archives of biochemistry and biophysics, 1976, Volume: 173, Issue:1 Topics: Animals; Carbon Monoxide; Cobalt; Copper; Cytochrome P-450 Enzyme System; Cytochromes; Ethyl Ethers; Hydrogen-Ion Concentration; Iron; Kinetics; Male; Mercury; Methylcholanthrene; Microsomes, Liver; NAD; Oxidoreductases; Oxygen Consumption; Partial Pressure; Phenobarbital; Rabbits	1976
Mechanism of dimethylnitrosamine metabolism and activation in rats. Journal of the National Cancer Institute, 1978, Volume: 61, Issue:5 Topics: Animals; Biotransformation; Carbon Dioxide; Cobalt; Dimethylnitrosamine; Formaldehyde; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrosamines; Nucleic Acids; Phenobarbital; Proadifen; Protein Binding; Rats; Subcellular Fractions	1978
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane. Cancer research, 1978, Volume: 38, Issue:12 Topics: Animals; Azo Compounds; Azoxymethane; Benzoflavones; Biotransformation; Chlorides; Cobalt; Diet; Disulfiram; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats	1978
Effect of agents known to alter carbon tetrachloride hepatotoxicity and cytochrome P-450 levels on carbon tetrachloride-stimulated lipid peroxidation and ethane expiration in the intact rat. Biochemical pharmacology, 1978, Feb-15, Volume: 27, Issue:4 Topics: 1-Propanol; Animals; Breath Tests; Carbon Tetrachloride; Cobalt; Drug Interactions; Ethane; Ethanol; Lipid Metabolism; Male; Maleates; Methylcholanthrene; Peroxides; Phenobarbital; Rats	1978
Metabolic activation of trichloroethylene into a chemically reactive metabolite toxic to the liver. The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:3 Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cobalt; Glutathione; In Vitro Techniques; Male; Microsomes, Liver; Muscle Proteins; Phenobarbital; Protein Binding; Rats; Trichloroethylene	1978
Failure of hypoactive hypertrophic smooth endoplasmic reticulum to produce cholestasis in rats. Toxicology and applied pharmacology, 1978, Volume: 45, Issue:1 Topics: Animals; Cholestasis; Cobalt; Endoplasmic Reticulum; Hypertrophy; Lithocholic Acid; Liver Function Tests; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats	1978
Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicology and applied pharmacology, 1978, Volume: 45, Issue:2 Topics: Animals; Castration; Cobalt; Dioxins; Female; Hemin; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Testosterone	1978
Lack of parallelism between microsomal enzyme induction and phenobarbital-induced hypercholeresis in the rat. Digestion, 1978, Volume: 17, Issue:6 Topics: Animals; Bile; Cholagogues and Choleretics; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Time Factors	1978
Alterations in the toxicity of thiodemeton due to the pretreatment of inducers, substrates and inhibitors of mixed function oxidase system. Bulletin of environmental contamination and toxicology, 1978, Volume: 20, Issue:6 Topics: Acetanilides; Aminopyrine; Animals; Cobalt; Cycloheximide; Disulfoton; Enzyme Induction; Ethylmorphine; Female; Insecticides; Male; Methylcholanthrene; Mixed Function Oxygenases; Nickel; Oxidoreductases; Phenobarbital; Rats	1978
Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. Biochemical pharmacology, 1977, Mar-15, Volume: 26, Issue:6 Topics: Animals; Cholesterol; Cobalt; Cytochrome P-450 Enzyme System; Desmosterol; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Metyrapone; Microsomes, Liver; Nitriles; Phenobarbital; Piperonyl Butoxide; Pregnenolone; Rats; Sterols	1977
N-Hydroxylation of arylamides by the rat and guinea pig. Evidence for substrate specificity and participation of cytochrome P1-450. Biochimica et biophysica acta, 1977, Jun-23, Volume: 498, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Bile; Cobalt; Cytochrome P-450 Enzyme System; Female; Fluorenes; Fluorides; Guinea Pigs; Hydroxyacetylaminofluorene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet	1977
Toxicity-related changes in benzene metabolism in vivo. Xenobiotica; the fate of foreign compounds in biological systems, 1977, Volume: 7, Issue:7 Topics: Acetylcysteine; Animals; Benzene; Breath Tests; Cobalt; Male; Phenobarbital; Phenols; Piperonyl Butoxide; Rats	1977
Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system. Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 292, Issue:1 Topics: Animals; Benserazide; Biotransformation; Cobalt; Cysteine; Glutathione; Humans; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Tyrosine	1976
Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro. Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:1 Topics: Animals; Apoproteins; Binding Sites; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Enzyme Inhibitors; Enzyme Precursors; Heme; Hemin; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats	1975
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis. Toxicology letters, 1992, Volume: 63, Issue:3 Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ketones; Liver; Male; Methylcholanthrene; Mirex; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Sprague-Dawley; Taurolithocholic Acid	1992
Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. The Biochemical journal, 1992, Aug-15, Volume: 286 ( Pt 1) Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Cell Nucleus; Cobalt; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenobarbital; Polymerase Chain Reaction; Pyrazoles; RNA, Messenger; Steroid Hydroxylases	1992
Protein changes associated with cobalt-induced epileptic activity in rat cerebral cortex. Epilepsy research, 1991, Volume: 8, Issue:2 Topics: Animals; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Male; Motor Cortex; Nerve Tissue Proteins; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains	1991
Role of cytochrome P450 in the control of the production of erythropoietin. Life sciences, 1990, Volume: 47, Issue:2 Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured	1990
Microsomal metabolism of hexavalent chromium. Inhibitory effect of oxygen and involvement of cytochrome P-450. Chemico-biological interactions, 1989, Volume: 69, Issue:2-3 Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromium; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Kinetics; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values	1989
Acute effect of amitriptyline, phenobarbital or cobaltous chloride on delta-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver. Japanese journal of pharmacology, 1989, Volume: 50, Issue:3 Topics: 5-Aminolevulinate Synthetase; Amitriptyline; Animals; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains	1989
Nephrotoxicity of N-(3,5-dichlorophenyl)succinimide metabolites in vivo and in vitro. Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3 Topics: Animals; Cobalt; Fungicides, Industrial; In Vitro Techniques; Kidney; Male; p-Aminohippuric Acid; Phenobarbital; Rats; Rats, Inbred F344; Succinimides	1988
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme. The Journal of biological chemistry, 1987, Dec-15, Volume: 262, Issue:35 Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger	1987
Practolol: aspects of its metabolism and ocular binding in the hamster. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:6 Topics: Animals; Cobalt; Cricetinae; Eye; Male; Mesocricetus; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Practolol	1986
A comparative study of the regulation of cytochrome P-450 and glutathione transferase gene expression in rat liver. Nucleic acids research, 1986, Mar-25, Volume: 14, Issue:6 Topics: Amitrole; Animals; Cell Nucleus; Cobalt; Cytochrome P-450 Enzyme System; DNA; Gene Expression Regulation; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Biosynthesis; Rats; Time Factors; Transcription, Genetic	1986
Oxidative metabolism of carbon disulfide by isolated rat hepatocytes and microsomes. Biochemical pharmacology, 1987, Feb-01, Volume: 36, Issue:3 Topics: Acetazolamide; Animals; Carbon Disulfide; Cobalt; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Sulfur	1987
Regulation of cytochrome P-450 gene expression. Studies with a cloned probe. The Journal of biological chemistry, 1985, Feb-10, Volume: 260, Issue:3 Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; DNA; Gene Expression Regulation; Male; Microsomes, Liver; Nucleic Acid Hybridization; Phenobarbital; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic	1985
Influence of pyrazolones on hepatic glutathione in rats. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1985, Volume: 8 Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide	1985
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes. Biochemical pharmacology, 1985, Dec-15, Volume: 34, Issue:24 Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats	1985
Induction of liver cytochrome P-450 in mice by warfarin. Comparison of warfarin-, phenobarbitone-, and cobalt-induced hepatic microsomal protein patterns by PAGE after partial purification on octyl-sepharose CL-4B. Biochemical pharmacology, 1985, Jan-01, Volume: 34, Issue:1 Topics: Animals; Chromatography, Agarose; Cobalt; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Proteins; Warfarin	1985
Effects of mixed-function oxidase modifiers on neurotoxicity of acrylamide in rats. Biochemical pharmacology, 1985, Apr-01, Volume: 34, Issue:7 Topics: Acrylamide; Acrylamides; Animals; Cobalt; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Male; Mixed Function Oxygenases; Nervous System; Paralysis; Phenobarbital; Rats; Rats, Inbred Strains	1985
Turnover of messenger RNA, apoprotein and haem of cytochrome P-450b + e induced by phenobarbitone in rat liver. The Biochemical journal, 1985, Jul-01, Volume: 229, Issue:1 Topics: 5-Aminolevulinate Synthetase; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Heme; Liver; Male; Phenobarbital; Rats; RNA, Messenger	1985
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium	1973
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:1 Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors	1974
The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro. Biochemical pharmacology, 1970, Volume: 19, Issue:2 Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Calcium; Chlorides; Cobalt; Copper; Cytochromes; Edetic Acid; Hexobarbital; In Vitro Techniques; Iron; Magnesium; Male; Manganese; Microsomes, Liver; NADP; Nitrophenols; Phenobarbital; Potassium; Rats; Strontium; Sulfates; Zinc; Zoxazolamine	1970
The effects of some anticonvulsant drugs on cobalt-induced epilepsy. Epilepsia, 1973, Volume: 14, Issue:2 Topics: Animals; Cobalt; Electroencephalography; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Frontal Lobe; Male; Phenobarbital; Phenytoin; Rats	1973
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats. Epilepsia, 1972, Volume: 13, Issue:3 Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography; Epilepsies, Partial; Epilepsy; Phenobarbital; Phenytoin	1972
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Kidney; Lethal Dose 50; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Time Factors; Tritium	1973
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cobalt; In Vitro Techniques; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mitochondria, Liver; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Time Factors; Tritium	1973
Drug interactions in experimental hepatic porphyria. A model for the exacerbation by drugs of human variegate porphyria. Enzyme, 1973, Volume: 16, Issue:1 Topics: 5-Aminolevulinate Synthetase; Administration, Oral; Allylisopropylacetamide; Animals; Chickens; Cobalt; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Humans; Injections, Intraperitoneal; Levulinic Acids; Liver; Male; Mitochondria, Liver; Models, Biological; Phenobarbital; Porphobilinogen; Porphyrias; Pyridines; Rats; Species Specificity; Spectrometry, Fluorescence	1973
Imipramine and chlorpromazine in hepatic microsomal systems. Advances in biochemical psychopharmacology, 1974, Volume: 9, Issue:0 Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Microsomes, Liver; Phenobarbital; Proadifen; Proteins; Spectrophotometry, Ultraviolet	1974
Apparent enzyme inhibition through enzyme-induction studies as a possible mode of action of certain cobalt compounds. Journal of pharmaceutical sciences, 1971, Volume: 60, Issue:12 Topics: Animals; Chlorides; Cobalt; Enzyme Induction; Enzyme Inhibitors; Female; Hexobarbital; Mice; Nitrites; Phenobarbital; Sleep; Zoxazolamine	1971
Therapeutic efficacy of cyclophosphamide as a function of its metabolism. Cancer research, 1972, Volume: 32, Issue:3 Topics: Acetamides; Animals; Carcinoma 256, Walker; Cobalt; Cyclophosphamide; Cytochromes; Female; In Vitro Techniques; Kinetics; Leukocyte Count; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Rats; Sodium Chloride; Sulfides	1972
Induction of hepatic mitochondrial ferrochelatase by phenobarbital. Biochemical and biophysical research communications, 1970, Aug-11, Volume: 40, Issue:3 Topics: Acyltransferases; Animals; Cobalt; Cycloheximide; Enzyme Induction; Heme; Kinetics; Levulinic Acids; Liver; Lyases; Male; Metabolism; Mitochondria, Liver; Nickel; Oxygen; Phenobarbital; Porphyrins; Rats; Succinates	1970
In vivo metabolism of 11-hydroxy-delta-tetrahydrocannabinol to two carboxylic acids and the effects of SKF 525-A, cobaltous chloride and phenobarbital on their formation in rats. Chemical & pharmaceutical bulletin, 1980, Volume: 28, Issue:7 Topics: Animals; Carboxylic Acids; Cobalt; Dronabinol; Liver; Phenobarbital; Proadifen; Rats	1980
8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes. Biochemical and biophysical research communications, 1982, Dec-15, Volume: 109, Issue:3 Topics: Animals; Cobalt; Dronabinol; Isomerism; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; NADP; Phenobarbital	1982
Rat liver microsomal transformation of ethene to oxirane in vitro. Toxicology letters, 1983, Volume: 19, Issue:3 Topics: Alkylation; Animals; Biotransformation; Cobalt; Ditiocarb; Ethylene Oxide; Ethylenes; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains	1983
Quantitative correlation between the metabolism and the mutagenic activity of N-nitrosopyrrolidine. Toxicology, 1984, Volume: 29, Issue:3 Topics: Animals; Biotransformation; Butylene Glycols; Cobalt; Hydroxylation; Male; Microsomes, Liver; Mutagenicity Tests; N-Nitrosopyrrolidine; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium	1984
[Mechanism of the protective effect of modifiers of the liver enzyme systems metabolyzing xenobiotics in acute T-2 mycotoxicosis]. Doklady Akademii nauk SSSR, 1984, Volume: 276, Issue:5 Topics: Acute Disease; Animals; Cobalt; Drug Evaluation, Preclinical; Enzyme Induction; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Sesquiterpenes; T-2 Toxin	1984
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3 Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Glutathione; Male; Methylcholanthrene; Oleandomycin; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin	1983
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver. Archives of biochemistry and biophysics, 1983, Volume: 225, Issue:1 Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Triazoles	1983
Induction of liver microsomal 2-hydroxylation of estradiol 17-sulfate by phenobarbital in male rat. Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:6 Topics: Animals; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 Enzyme System; Estradiol; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1983
[Effect of pyrazolone derivatives on the level of reduced glutathione in rat liver]. Biomedica biochimica acta, 1983, Volume: 42, Issue:5 Topics: Aminopyrine; Animals; Antipyrine; Cobalt; Female; Glutathione; Liver; Male; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains	1983
Study on in vivo and in vitro metabolism of dimethylformamide in male and female rats. Toxicology, 1984, Volume: 29, Issue:3 Topics: Aminopyrine; Animals; Biotransformation; Cobalt; Dimethylformamide; Drug Interactions; Female; Formamides; Injections, Intraperitoneal; Liver; Male; Microsomes; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors	1984
Isoniazid hepatoxicity: the relationship between covalent binding and metabolism in vivo. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:2 Topics: Acetylation; Amidohydrolases; Animals; Biotransformation; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Cobalt; Hydrolysis; Isoniazid; Liver; Male; Microsomes, Liver; Nitrophenols; Organophosphorus Compounds; Phenobarbital; Protein Binding; Rats	1980
Effect of enzyme inducers and inhibitors and glutathione precursor and depleter on induced acute aflatoxicosis in rabbits. American journal of veterinary research, 1982, Volume: 43, Issue:6 Topics: Acute Disease; Aflatoxin B1; Aflatoxins; Animals; Benzoflavones; Carcinogens; Chlorides; Cobalt; Cysteine; Enzyme Induction; Enzyme Inhibitors; Glutathione; Goats; Liver; Male; Maleates; Microsomes, Liver; Phenobarbital; Phenylbutazone; Piperonyl Butoxide; Rabbits; Rats; Stanozolol	1982
Effects of cobalt chloride and cycloheximide on the hepatic microsomal enzyme system and biliary excretion rate in control and phenobarbital-pretreated rats. Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 262, Issue:2 Topics: Animals; Bile; Bromcresol Green; Cobalt; Cycloheximide; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Sleep	1983
[Activity of key enzymes of heme synthesis and degradation and contents of cytochromes b5 and P-450 in rat liver]. Biokhimiia (Moscow, Russia), 1981, Volume: 46, Issue:8 Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Kinetics; Liver; Mixed Function Oxygenases; Phenobarbital; Rats	1981
Control of delta-aminolaevulinate synthase and haem oxygenase in chronic-iron-overloaded rats. The Biochemical journal, 1981, Oct-15, Volume: 200, Issue:1 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1981
Mutagenic activation of 2,4-diaminoanisole and 2-amino-fluorene by isolated rat liver nuclei and microsomes. Chemico-biological interactions, 1980, Volume: 31, Issue:1 Topics: Animals; Anisoles; Benzoflavones; beta-Naphthoflavone; Cell Nucleus; Cobalt; Flavonoids; Fluorenes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mutagens; NADP; Phenobarbital; Phenylenediamines; Rats; Salmonella typhimurium	1980
Urinary excretion of thiodiglycollic acid and hepatic content of free thiols in rats at different levels of exposure to vinyl chloride. Journal of hygiene, epidemiology, microbiology, and immunology, 1980, Volume: 24, Issue:3 Topics: Alcohol Oxidoreductases; Animals; Biotransformation; Cobalt; Glutathione Reductase; Liver; Male; Oxygenases; Phenobarbital; Rats; Sulfhydryl Compounds; Thioglycolates; Vinyl Chloride; Vinyl Compounds	1980
Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor. American journal of veterinary research, 1982, Volume: 43, Issue:1 Topics: Animals; Atractyloside; Benzoflavones; beta-Naphthoflavone; Cobalt; Cysteine; Glycosides; Kidney Tubules; Lethal Dose 50; Liver; Male; Maleates; Phenobarbital; Phenylbutazone; Piperonyl Butoxide; Plants, Toxic; Rats; Rats, Inbred Strains; Stanozolol	1982
Does cobalt pretreatment of mice induce a phenobarbitone-type cytochrome P-450? Xenobiotica; the fate of foreign compounds in biological systems, 1982, Volume: 12, Issue:5 Topics: Animals; Biphenyl Compounds; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; Kinetics; Metyrapone; Mice; Phenobarbital	1982
Non-linear kinetics of microsomal styrene monooxygenase after phenobarbital pre-treatment. Experientia, 1980, Jun-15, Volume: 36, Issue:6 Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Styrenes	1980
Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat. Toxicology, 1993, Nov-12, Volume: 84, Issue:1-3 Topics: Animals; Body Weight; Cobalt; Drug Synergism; Fungicides, Industrial; Injections, Intraperitoneal; Kidney; Male; Microsomes; Organ Size; Phenobarbital; Piperonyl Butoxide; Proteinuria; Rats; Rats, Inbred F344; Succinimides	1993
Use of Fourier transform infrared spectroscopy for the simultaneous quantitative detection of metal carbonyl tracers suitable for multilabel immunoassays. Analytical biochemistry, 1993, Volume: 208, Issue:1 Topics: Carbamazepine; Cobalt; Evaluation Studies as Topic; Fourier Analysis; Humans; Immunoassay; Manganese; Organometallic Compounds; Phenobarbital; Spectrophotometry, Infrared	1993
Endoplasmic reticulum proliferates without an increase in cytochrome P-450 in hepatocytes of mice treated with phenobarbital and cobalt chloride. European journal of cell biology, 1995, Volume: 68, Issue:3 Topics: Animals; Cells, Cultured; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Liver; Male; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Phospholipids	1995
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver. The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorides; Cobalt; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferric Compounds; Gene Expression Regulation, Enzymologic; Heme; Hemin; Liver; Molecular Weight; Nuclear Proteins; Phenobarbital; Protoporphyrins; Rats; RNA, Messenger; Steroid Hydroxylases; Transcription, Genetic	1997
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension. Molecular pharmacology, 1999, Volume: 56, Issue:1 Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine	1999
Paraquat detoxicative system in the mouse liver postmitochondrial fraction. Archives of biochemistry and biophysics, 2002, Jun-01, Volume: 402, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E	2002
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:3 Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Insecticides; Male; Methylcholanthrene; Motor Activity; Nervous System Diseases; Neurotoxins; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Tremor	2003
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. Journal of neural transmission (Vienna, Austria : 1996), 2004, Volume: 111, Issue:9 Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combinations; Drug Synergism; Electroshock; Epilepsy; Epilepsy, Absence; Hippocampus; Male; Mice; Mice, Inbred DBA; Neuroprotective Agents; Phenobarbital; Phenytoin; Piracetam; Valproic Acid	2004
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression. Toxicology letters, 2013, May-23, Volume: 219, Issue:2 Topics: Animals; Blotting, Western; Chromatin Immunoprecipitation; Cobalt; Constitutive Androstane Receptor; Gene Expression Regulation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Immunoprecipitation; Male; Mice; Mice, Inbred C3H; Phenobarbital; Plasmids; Real-Time Polymerase Chain Reaction; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear	2013